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Pyrimidine derivativesR 0510 DOI: 10.1002/chin.201045158

Synthesis of Aryl-Substituted Pyrimidines by Site-Selective Suzuki-—Miyaura Cross-Coupling Reactions of 2,4,5,6-Tetrachloropyrimidine. — Suzuki—Miyaura reactions of the tetrachloropyrimidine (I) allow a convenient synthesis of mono-, di, tri-, and tetraarylpyrimidines, which are not readily available by other methods. The amount of arylboronic acid, the temperature, and the reaction time are essential to avoid multi-coupling reactions. — (HUSSAIN, M.; NGUYEN, T. H.; KHERA, R. A.; MALIK, I.; ZINAD, D. S.; LANGER*, P.; Adv. Synth. Catal. 352 (2010) 9, 1429-1433, DOI:10.1002/adsc.201000020 ; Inst. Chem., Univ. Rostock, D-18059 Rostock, Germany; Eng.) — Kieslich

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ChemInform 2010, 41, issue 45 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim