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ChnœrResearchVOLUME 46 •NUMBER 12 •CNREA8 •PP 6019-6537
CONTENTSt
Asterisks * preceding page numbers refer to studies using human-derived material.
Perspectives in Cancer Research
6019 Chromosome Translocations and Human Cancer. Carlo M. Croce.
BASIC SCIENCES
6024 DNA Damage in Cultured LI 210 Cells by 2-Haloethyl Estersof (Methylsulfonyl)methanesulfonic Acid. Jo Ann Alexander,Bonnie J. Bowdon and Glynn P. Wheeler.
*6029 Detection of Activated M, 21,000 Protein the Product of rasOncogenes, Using Antibodies with Specificity for Amino Acid 12.Gail Wong, Norman Arnheim, Robin Clark, Peter McCabe,Michael Innis, Lois Aldwin, Danute Nitecki and FrankMcCormick.
*6034 Cloning of Estrogen-regulated Messenger RNA Sequences fromHuman Breast Cancer Cells. Felicity E. B. May and Bruce R.Westley.
6041 Development and Inheritance of Osmotic Tolerance in a Line ofSpontaneously Transformed BALB/3T3 Cells. Timothy L.Hennessey and Harry Rubin.
* 6049 Lipoprotein Modulation of the Intracellular Localization of Pro
tein Kinase C and Alteration of Phorbol Ester-stimulated Differentiation in the Human Monoblastic U937 Cell Line. D. KirkWays. Richard C. Dodd, John T. Gwynne and H. Shelton Earp.
:':6054 Two Mechanisms of Synergism When Amphotericin B Is Used inCombination with Actinomycin D or l-(2-Chloroethyl)-3-cyclo-hexyl-1-nitrosourea against the Human Promyelocytic LeukemiaCell Line HL-60. Aline Vertut-Croquin, Janina Brajtburg andGerald Medoff.
•'•60S9 Role of Intracellular Calcium Ion in Human Promyelocytic Leukemia HL-60 Cell Differentiation. Toshiro Okazaki, ToshihiroMochizuki, Masaro Tashima, Hiroyoshi Sawada and HarutoUchino.
:':6064 Identification and Quantitative Determination of Aniline and To-luidines in Human Urine. Karam El-Bayoumy. Jean M. Donahue,Stephen S. Hecht and Dietrich Hoffmann.
:':<i06N Changes in Antigen Expression on Human FME Melanoma Cells
after Exposure to Photoactivated Hematoporphyrin Derivative.Catharina de Lange Davies, Andre Western, Tore Lindmo andJohan Moan.
* 6073 Modulation of the Growth of a Human Erythroleukemic Cell Line(KS62) by Prostaglandins: Antiproliferative Action of Prostaglan-din A. M. Gabriella Santoro, Antonella Crisari, Arrigo Benedettoand Carla Amici.
* 6078 Changes in Isoenzyme Profiles during Inductionof Differentiationin Human Myelomonocytic Leukemia Cell Lines. Hans G.Drexler, Kazuyuki Otsuka, Gerhard Gaedicke and JunMinowada.
~'¡*6083 Potentiation of Lymphocyte Responses by Monoclonal Antibodies
to the Ganglioside GD3.Peter Mersey,Stephen D. Schibeci, PhillipTownsend, Christine Burns and David A. Cheresh.
•'•6(l'»l
* 6095
*6101
6105
6111
'''6116
6120
6125
6131
'!>6U6
*6139
*6143
6149
*6156
6160
Comparison of the Effects of an Ornithine Decarboxylase Inhibitor on the Intestinal Epithelium and on Intestinal Tumors. PeterJ. M. Tutton and David H. Barkla.
Release of a Sodium Transport Inhibitor(Inhibitin) from CulturedHuman Cancer Cells. Kevin Morgan, Gillian Spurlock, RichardC. Brown and M. Afzal Mir.
Pharmacokinetics of Intraventricularand IntravenousTriethylenethiophosphoramide (Thiotepa) in Rhesus Monkeysand Humans. John M. Strong, Jerry M. Collins, Cynthia Lesterand David G. Poplack.
Quantitative Analysis of Cellular Glutathione by Flow CytometryUtilizing Monochlorobimane:Some Applications to RadiationandDrug Resistance in Vitro and in Vivo. Glenn C. Rice, Edward A.Bump, Dennis C. Shrieve, William Lee and Mary Kovacs.
Effects of Concomitant and Sinecomitant Immunity on Postsurgi-cal Metastasis in Mice. Shinhachiro Nomi, Kazuyo Naito, BarryD. Kahan and Neal R. Pellis.
Effect of Cytotoxic Drugs on Estrogen Receptor Expression andResponse to Tamoxifen in MCF-7 Cells. Robert Clarke, JanetMorwood, Hendrik W. van den Berg, John Nelson and RichardF. Murphy.
Anthracycline Photoaffmity Labeling of a Mitochondria! Polypep-tide in P388 Murine Leukentic Cell Lines. Steven D. Averbuch,Constance J. Glover and Ronald L. Felsted.
Effects of 7-A-O-Methylnogarol (Menogaril) on L1210 Cell Progression in Vitro and in Vivo. Earl G. Adams and Bijoy K.Bhuyan.
Metastatic Potential and Spontaneous Mutation Rates: Studieswith Two Murine Cell Lines and Their Recently Induced Metastatic Variants. Wayne S. Kendal and Philip Frost.
Increase in Human Exposure to Methylamine Precursors of .V-Nitrosamines after Eating Fish. Steven H. Zeisel and Kerry-AnnDaCosta.
Inhibitionof Human DNA Polymerase a by a,-Antichymotrypsin.Michio Tsuda, Masashi Masuyama and Tsunehiko Katsunuma.
Characterization of the CA 125 Antigen Associated with HumanEpithelial Ovarian Carcinomas. H. M. Davis, V. R. Zurawski,Jr.,R. C. Bast, Jr.. and T. L. Klug.
Involvement of Protein Kinase C Activation in Ornithine Decarboxylase Gene Expression in Primary Culture of Newborn MouseEpidermal Cells and in Skin Tumor Promotion by 12-O-Tetradec-anoylphorbol-13-acetate. Ajit K. Verma, Rey-Chen Pong andDeborah Erickson.
c»-Diamminedichloroplatinum(II)-inducedSister Chromatid Exchange: An Indicatorof Sensitivity and Heterogeneity in PrimaryHuman Tumor Cell Cultures. Philip J. Tofilon, Charlotte M.Vines, FräserL. Baker, Dennis F. Deen and William A. Brock.
Effect of Sodium Phénobarbitaland Sodium Saccharin in AIN-76A Diet on Carcinogenesis Initiated with yV-|4-(5-Nitro-2-furyl)-2-thiazolyl|formamide and iV./V-Dibutylnitrosaminein Male F344Rats. Katsumi Imaida and Ching Yung Wang.
t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.
Research. on January 26, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from
6165 Differential Turnoverof the Subunits of Ribonucleotide ReducÃasein Synchronized Leukemia L1210 Cells. Eric H. Rubin and JosephG. Cory.
*6169 Enhanced Levels of Insulin-like Growth Factor Messenger RNAin Human Colon Carcinomas and Liposarcomas. James V. Tricoli.Leslie B. Rail, Constantine P. Karakousis, Lemuel Herrera,Nicholas J. Petrelli, Graeme I. Bell and Thomas B. Shows.
*6174 Implication of Chromosome 11 in the Suppression of NeoplasticExpression in Human Cell Hybrids. Eri S. Srivatsan, William F.Benedict and Eric J. Stanbridge.
6180 Inhibition of Junctional IntercellularCommunicationas a PossibleShort-Term Test to Detect Tumor-promotingAgents: Results withNine Chemicals Tested by Dye Transfer Assay in Chinese Hamster V79 Cells. Marco J. Zeilmaker and Hiroshi Yamasaki.
* 6187 Distinct Functional Domains on the RecombinantHuman ImmuneInterferon Molecule. M. Reza Ziai, Luisa Imberti, MichikoKobayashi, Bice Perussia, Giorgio Trinchieri and SoldanoFerrane.
•'"di'*IAlteration of Fluorouracil Metabolism in Human Colon Cancer
Cells by Dipyridamole with a Selective Increase in Fluorodeox-yuridine Monophosphate Levels. Jean L. Grem and Paul H.Fischer.
6200 Peroxidative Metabolism of a Carcinogen, A'-Hydroxy-A'-I-fluo-renylacetamide, by Rat Uterus and Mammary Gland in Vitro.Danuta Malejka-Giganti, Clare L. Ritter, Richard W. Decker andJean M. Suilman.
*6207 2',5'-Oligoadenylate Synthetase Activity in Human Mammary
Tumors and Its Potential Correlation with Tumor Growth orHormonal Responsiveness. Dai Kee Liu, Gail F. Owens and PeterD. Feil.
*62I1 Analysis of Receptors, Cell Surface Antigens, and Proteins inHuman Melanoma Cell Lines Resistant to Human Recombinantß-or y- Interferon. Katsushige Gomi. Shiro Akinaga, Tetsuo Okaand Makoto Morimoto.
* 6217 Enhanced Expression of the N-myc Gene in Wilms' Tumors. Perry
D. Nisen, Kathryn A. Zimmerman. Sean V. Cotter, Fred Gilbertand Frederick W. Alt.
6223 Experimental Radioimmunotherapy of Murine Lymphoma with1J1l-labeled Anti-T-Cell Antibodies. Christopher C. Badger,Kenneth A. Krohn, Howard Shulman, Nancy Flournoy and IrwinD. Bernstein.
6229 Temperature Measurements in Normal and Tumor Tissue of DogsUndergoing Whole Body Hyperthermia. Donald E. Thrall,Rodney L. Page. Mark W. Dewhirst. Robert E. Meyer, P. JackHoopes and Joe N. Kornegay.
*6236 Inhibitory Effects of Elevated Temperature on Human CytokineProduction and Natural Killer Activity. Charles A. Dinarello, RoyA. Dempsey. Mark Allegretta. Gail LoPreste, Nicholas Dainiak.David R. Parkinson and James W. Mier.
6242 Hyperthermic Potentiation of cis-Diamminedichloroplatinum(II)Cytotoxicity in Chinese Hamster Ovary Cells Resistant to theDrug. Kent E. Wallner. Michael W. DeGregorio and Gloria C.Li.
6246 Effect of Inhibitors of Ornithine Decarboxylase on RetrovirusInducedTransformation of Murine Erythroid Precursors in Vitro.S. Peter Klinken. Manuel J. Castilla and Snorri S. Thorgeirsson.
6250 Water-soluble /V-substituted Iminodiacetato(l,2-diaminocyclo-hexane)-platinum(II) Complexes as Potential Antitumor Agents.M. P. Hacker, A. R. Khokhar. I. H. Krakoff, D. B. Brown andJ. J. McCormack.
6255 Metabolism of Nitromiphene (CI 628) in the Immature FemaleRat: Role of Gastrointestinal Microflora in the Biotransformationof a Triarylethylene Antiestrogen. Peter C. Ruenitz and JeromeR. Bagley.
6260 Inhibition of Dimethyl Sulfoxide Induced Erythropoietic Differentiation of Murine Erythroleukemia Cells in Culture. MagdaForesti, Luciano Gaudio, Giuseppe Ceraci and Paola Manduca.
*6264 Enhanced Inhibition of Colony Formation of Human Renal CellCarcinoma in Soft Agar by the Combination of a-Difluoromethyl-ornithine and Recombinant 7-Interferon. Kazuo Gohji, Shin-ichiMurao, Sakan Maeda, Taketoshi Sugiyama and Sadao Kamidono.
6269 Toxicity and Antitumor Activity of cif-Bis-cyclopentenecarbox-ylato-l,2-diaminocyclohexane Platinum(II) Encapsulated in Mul-tilamellar Vesicles. R. Perez-Soler, Abdul R. Khokhar, M. P.Hacker and G. Lopez-Berestein.
*6274 (al modulili Antagonism and Growth-inhibiting Activity of Tri-phenylethylene Antiestrogens in MCF-7 Human Breast CancerCells. Alberto Gulino. Giuseppina Barrera. Alessandra Vacca,Antonietta Farina, Carlo Ferretti, Isabella Screpanti, Mario U.Dianzani and Luigi Frati.
6279 Comparison and Characterization of Growth Inhibition in 1,121(1Cells by a-Difluoromethylornithine, an Inhibitor of OrnithineDecarboxylase, and Ar',yV8-Bis(ethyl)spermidine,an Apparent
Regulator of the Enzyme. Carl W. Porter, Barbara Ganis, TimVinson, Laurence J. Marton. Debora L. Kramer and RaymondJ. Bergeron.
"'•62Kh Modulation of Thiopurine Cytotoxicity in the HL-60 Cell Line by
Physiological Concentrations of Hypoxanthine. Solomon Zimm,Gloria E. Johnson and David G. Poplack.
6290 Isolation and Characterization of a Chinese Hamster Ovary CellLine Resistant to Bifunctional Nitrogen Mustards. Craig N.Robson, Janice Alexander, Adrian L. Harris and Ian D. Hickson.
!*:6295 Enhanced Expression of the c-myc Gene in Bovine LeukemiaVirus-inducedBovine Tumors. Phalguni Gupta, S. V. S. Kashmiri.M. D. Erisman, P. G. Rothberg. S. M. Astrin and J. F. Ferrer.
6299 Effect of Glucose on Systemic Hemodynamics and Blood FlowRate in Normal and Tumor Tissues in Rats. Donald J. DiPette,Kimberly A. Ward-Hartley and Rakesh K. Jain.
*6305 In Vitro Sensitivity of Normal and Hereditary RetinoblastomaFibroblasts to DNA-damaging Agents. William G. Woods andTimothy D. Byrne.
*6311 Mechanism of Interaction between Antineoplastic Agents andNatural Differentiation Factors in the Induction of Human Leu-kemic Cell Maturation. Yoshio Honma. Chieko Honma andAlexander Bloch.
6316 Modulation of Cell Growth, Differentiation, and Production ofInterleukin-3 by la,25-Dihydroxyvitamin I)i in the Murine Mye-lomonocytic Leukemia Cell Line WEHI-3. Junko Abe, YoichiroMoriya. Motoo Saito, Yutaka Sugawara, Tatsuo Suda and YasuhoNishii.
6322 Relationship between Expression of Tumor-specific Transplantation Antigens and Neoplastic Transformation in an Ultraviolet Radiation-induced Murine Skin Cancer. Honnavara N.Ananthaswamy.
Terminal Erythroid Differentiation in the K-562 Cell Line by 1-/3-D-Arabinofuranosylcytosine:Accompanimentby c-myc Messenger RNA Decrease. G. L. Bianchi Scarrà ,M. Romani, D. A.Coviello. C. Garre, R. Ravazzolo, G. Vidali and F. Ajmar.
:': 6.Y13 Presence of Chromosomal Abnormalities and Lack of AIDS Retrovirus DNA Sequences in AIDS-associated Kaposi's Sarcoma.
Pasquale Delli Bovi, Emilio Donti, Daniel M. Knowles II, AlvinFriedman-Kein, Paul A. Luciw. DiñoDina, Riccardo Dalla-Favera and Claudio Basilico.
Continued
Research. on January 26, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from
*6339 Relation of in Vitro Properties to Tumorigenicity for a Seriesof Sublines of the Human Breast Cancer Cell Line MCF-7.W. Barkley Butler. Pamela J. Berlinski, Roberta M. Hillman,William H. Kelsey and Michele M. Toenniges.
6349 Forestomach Lesions in Rats and Mice Administered 3-Chloro-2-methylpropene by Gavage for Two Years. Po C. Chan, Joseph K.Haseman, Gary A. Boorman, James Huff, Allan G. Manus andRichard H. Cardy.
*6353 Presence of Proteolytically Processed Keratins in the CultureMedium of MCF-7 Cells. Raymond Chan, Paul V. Rossitto.Benjamin F. Edwards and Robert D. Cardiff.
*6360 Growth-promoting Effect of 12-O-Tetradecanoylphorbol-13-ace-tate on Cultured Normal Human Fetal Kidney Epithelial Cells.Chia-cheng Chang, Ruth E. Gibson-D'Ambrosio, James E. Troskoand Steven M. D'Ambrosio.
* 6364 Culture of Squamous Head and Neck Cancer on 3T3 Fibroblastsfollowing Isokinetic Velocity Sedimentation. Melody A. Cobleigh.John L. Kennedy, James H. Hill, Karin M. Lindholm, PatriciaW. Langenberg and Edward L. Applebaum.
* 6369 Two Murine Monoclonal Antibodies against Human LungCancer-associated Antigens. Katsuyuki Endo, Hiroshi Kamma andTakesaburo Ogata.
* 6374 Preferential Expression of a M, \ 55,000 Milk-Fat-Globule Membrane Glycoprotein on Luminal Epithelium of Lobules in HumanBreast. Ashraf Imam, Mary M. Drushella, Clive R. Taylor andZoltánA. Tokés.
"'"6380 Heritable Variation in Expression of Multiple Tumor Associated
Epitopes on a High Molecular Weight Mucin-like Antigen. PeterS. Linsley, Vincent Ochs, Diane Horn, David B. Ring and ArthurE. Frankel.
6387 A New Concept for Macromolecular Therapeutics in CancerChemotherapy: Mechanism of TumoritropicAccumulationof Proteins and the Antitumor Agent Smancs. Yasuhiro Matsumura andHiroshi Maeda.
* 6393 Monoclonal Antibodies against Cell-Surface Antigens of the Met-astatic Rat 13762NF Mammary Adenocarcinoma and TheirCross-Reactivity with Human Breast Carcinomas. Susan M.North, Peter A. Steck and Garth L. Nicolson.
* 6400 Establishment of a Novel Acute Monoblastic Leukemia Cell Line(YK-M2) Having a Near-Triploid Karyotype. Hitoshi Ohno,Shirou Fukuhara, Shoichi Doi, Michihiko Yamasowa, Yuu Arita,Masataka Sasada, Yohichirou Ohno, Kiyoshi Akasaka and HarutoUchino.
* 6406 Differential Expression of Cell Surface Antigens and Glial Fibril-lary Acidic Protein in Human Astrocytoma Subsets. Wolfgang J.Rettig, Pilar Garin Chesa, H. Richard Beresford, Hans-JoachimFeickert, Mark T. Jennings, James Cohen, Herbert F. Oettgenand Lloyd J. Old.
*6413 Enhancement by -y-Interferonof in Vivo Tumor Radiolocalizationby a Monoclonal Antibody against HLA-DR Antigen. GailRowlinson, Frances Balkwill, Deborah Snook. George Hookerand Agamemnon A. Epenetos.
*6418 Ability of Inhibitors of Glycosylation and Protein Synthesis toSensitize Cells to Abrin, Ricin, Shigella Toxin, and PseudomonasToxin. Kirsten Sandvig, Tor Inge T0nnessen and Sjur Olsnes.
6423 Induction of Prostate Carcinoma ¡nSitu at High Incidence inF344 Rats by a Combination of 3,2'-Dimethyl-4-aminobiphenyl
and Ethinyl Estradiol. Tomoyuki Shirai. Shoji Fukushima, EtsuoIkawa, Yoshiaki Tagawa and Nobuyuki Ito.
6427
6433
6438
*6446
6452
6456
6462
6471
6475
6481
6489
6494
6503
6509
6513
Continued
Microinjection of the ras Oncogene Protein into NonestablishedRat Embryo Fibroblasts. Neil F. Sullivan, Raymond W. Sweet,Martin Rosenberg and James R. Feramisco.
In Vitro Transformation of Primary Rat Trachea! Epithelial Cellsby 5-Azacytidine. Cheryl Walker and Paul Nettesheim.
Collagenase and Elastase Production by Mouse Mammary Adenocarcinoma Primary Cultures and Cloned Cells. Maria Zeydel.Sachiko Nakagawa, Luis Biempica and Shizuko Takahashi.
Membrane-associated Glycoprotein (gpl60) Identified on HumanLung Tumors by a Monoclonal Antibody. Samuel Zylstra, Fang-An Chen, Swapan K. Ghosh, Elizabeth A. Repasky. Urna Rao,Hiroshi Takita and Richard B. Bankert.
CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS
Effects of a-Naphthoflavone on Levels of Sister Chromatid Exchanges in Lymphocytes from Active and Passive Cigarette Smokers: Dose-Response Relationships. Gwen W. Coliman, KarstenLundgren. David Shore, Claudia L. Thompson and George W.Lucier.
Characterization of Malignant Peripheral Blood Cells of Juvenile Chronic Myelogenous Leukemia. Zeev Estrov, BarryZimmerman. Tom Grunberger. Judy Chao, Ikuko E. Teshima,Helen S. Chan and Melvin H. Freedman.
Phenotypic Characterization of Lung Cancers in Fine NeedleAspiration Biopsies Using Monoclonal Antibody B72.3. WilliamW. Johnston. Cheryl A. Szpak, Ann Thor and Jeffrey Schlom.
Cancer Procoagulant in Human Tumor Cells: Evidence from Melanoma Patients. Maria Benedetta Donati, Carlo Gambacorti-Passerini. Bruno Casali, Anna Falanga, Paola Vannotti, GiuseppeFossati, Nicola Semeraro and Stuart G. Gordon.
Histochemical Studies with an Estrogen Receptor-related Proteinin Human Breast Tumors. Antonio Cano, Arnold I. Coffer, RemyAdatia, Rosemary R. Millis, Robert D. Rubens and Roger J. B.King.
Correlations between Immunological Phenotype and Karyotype inMalignant Lymphoma. Ellis G. Levine. Diane C. Arthur,Kazimiera J. Gajl-Peczalska, Tucker W. LeBien. Bruce A.Peterson, David D. Hurd and Clara D. Bloomfield.
Development of Primary and Secondary Immune Responses toMouse Monoclonal Antibodies Used in the Diagnosis and Therapyof Malignant Neoplasms. Nigel S. Courtenay-Luck, AgamemnonA. Epenetos, Richard Moore, Mark Lärche,Dimitris Pectasides,Babu Dhokia and Mary A. Ritter.
Preoperative Imaging of Colorectal Carcinoma with '"In-labeled
Anticarcinoembryonic Antigen Monoclonal Antibody. J. DavidBeatty, Rosemary B. Duda, Lawrence E. Williams, KhalilSheibani. Raymond J. Paxton, Barbara G. Beatty, Vicki J.Philben, John L. Werner, John E. Shively, William G. Vlahos,William A. Kokal, Daniel U. Riihimaki, Jose J. Terz andLawrence D. Wagman.
Testis Imaging with '"In-labeled Anticarcinoembryonic Antigen
Monoclonal Antibody:Identificationof CarcinoembryonicAntigenin Normal Germ Cells. BarbaraG. Beatty. Raymond J. Paxton,Khalil Sheibani, Rosemary B. Duda, Lawrence E. Williams, JohnE. Shively and J. David Beatty.
Incorporation of lododeoxyuridine into DNA of Granulocytes inPatients. Karl Belanger. Raymond W. Klecker, Jr.. Jan Rowland,Timothy J. Kinsella and Jerry M. Collins.
Development of an Assay System for the Detection and Classification of Methotrexate Resistance in Fresh Human LeukemicCells. Sjoerd Rodenhuis. John J. McGuire, RamaswamyNarayanan and Joseph R. Benino.
This Ono
ERXW-180-Q5WCResearch. on January 26, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from
6520 Purification, Partial Characterization, and Clinical Evaluation of 6526 Erratuman Adenocarcinoma-associated Antigen. Valerian B. Pinto, Frank J. A. Milner et al., 45:6347-6354, 1985.B. Gelder and Don M. Morris. 652? Acknowledgment to Reviewers
6525 Announcements 6536 Author Index
Beginning January 1987, Cancer Research will be published twice a month. Issues will be numbered from 1 through 24 and dated the 1st and 15th dayof each month. All of the subject categories covered by the journal will be represented in every issue.
NOTE: Advance registration form for 78th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.
Research. on January 26, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from
Cancer Research
VOLUME 46 •NUMBER 12
CONTENTS Arranged by Subject Category
Perspectives in Cancer Research
6019 Chromosome Translocations and Human Cancer. Carlo M. Croce.
BASIC SCIENCES
Biochemistry and Biophysics
* 6049 Lipoprotein Modulation of the Intracellular Localization of Protein Kinase C and Alteration of Phorbol Ester-stimulated Differentiation in the Human Monoblastic U937 Cell Line. D. KirkWays, Richard C. Dodd. John T. Gwynne and H. Shelton Earp.
* 6054 Two Mechanisms of Synergism When Amphotericin B Is Used inCombination with Actinomycin D or l-(2-Chloroethyl)-3-cyclo-hexyl-1-nitrosourea against the Human Promyelocytic LeukemiaCell Line HL-60. Aline Vertut-Croquin, Janina Brajtburg andGerald Medoff.
:'r:6068 Changes in Antigen Expression on Human FME Melanoma Cells
after Exposure to Photoactivated Hematoporphyrin Derivative.Catharina de Lange Davies, Andre Western. Tore Lindmo andJohan Moan.
* 6078 Changes in Isoenzyme Profiles during Inductionof Differentiationin Human Myelomonocytic Leukemia Cell Lines. Hans G.Drexler, Kazuyuki Otsuka, Gerhard Gaedicke and JunMinowada.
* 6095 Release of a Sodium Transport Inhibitor(Inhibitin) from CulturedHuman Cancer Cells. Kevin Morgan. Gillian Spurlock, RichardC. Brown and M. Afzal Mir.
6120 Anthracycline Photoaffinity Labeling of a Mitochondrial Polypep-tide in P388 Murine Leukemic Cell Lines. Steven D. Averbuch,Constance J. Glover and Ronald L. Felsted.
*6139 Inhibition of Human DNA Polymerase a by «i-Antichymotrypsin.Michio Tsuda, Masashi Masuyama and Tsunehiko Katsunuma.
"'•6143Characterization of the CA 125 Antigen Associated with Human
Epithelial Ovarian Carcinomas. H. M. Davis, V. R. Zurawski,Jr.,R. C. Bast, Jr., and T. L. Klug.
6165 Differential Turnoverof the Subunits of Ribonucleotide ReducÃasein Synchronized Leukemia LI 210 Cells. EricH. Rubin and JosephG. Cory.
*6207 2',5'-Oligoadenylate Synthetase Activity in Human Mammary
Tumors and Its Potential Correlation with Tumor Growth orHormonal Responsiveness. Dai Kee Liu. Gail F. Owens and PeterD. Feil.
:':62II Analysis of Receptors, Cell Surface Antigens, and Proteins in
Human Melanoma Cell Lines Resistant to Human Recombinantß-or -y-Interferon. Katsushige Gomi. Shiro Akinaga, Tetsuo Oka
and Makoto Morimoto.
6255 Metabolism of Nitromiphene (CI 628) in the Immature FemaleRat: Role of Gastrointestinal Microflora in the Biotransformationof a Triarylethylene Antiestrogen. Peter C. Ruenitz and JeromeR. Bagley.
* 6374 Preferential Expression of a M, 155,000 Milk-Fat-Globule Membrane Glycoprotein on Luminal Epithelium of Lobules in HumanBreast. Ashraf Imam, Mary M. Drushella, Clive R. Taylor andZoltánA. Tokés.
* Indicates studies using human-derived material.
6438
* 6(159
:':6073
6131
6279
6299
^6305
*6311
* 6333
* 6339
*6353
*6360
'*"6364
Ability of Inhibitors of Glycosylation and Protein Synthesis toSensitize Cells to Abrin, Ricin, Shigella Toxin, and PseudomonasToxin. Kirsten Sandvig, Tor Inge T0nnessen and Sjur Olsnes.
Collagenase and Elastase Production by Mouse Mammary Ade-nocarcinoma Primary Cultures and Cloned Cells. Maria Zeydel.Sachiko Nakagawa, Luis Biempica and Shizuko Takahashi.
Biology
Role of Intracellular Calcium Ion in Human Promyelocytic Leukemia HL-60 Cell Differentiation. Toshiro Okazaki, ToshihiroMochizuki, Masaro Tashima, Hiroyoshi Sawada and HarutoUchino.
Modulation of the Growth of a Human Erythroleukemic Cell Line(K562) by Prostaglandins: Antiproliferative Action of Prostaglan-din A. M. Gabriella Santoro, Antonella Crisari, Arrigo Benedettoand Carla Amici.
Metastatic Potential and Spontaneous Mutation Rates: Studieswith Two Murine Cell Lines and Their Recently Induced Metastatic Variants. Wayne S. Kendal and Philip Frost.
Comparison and Characterization of Growth Inhibition in I 121(1Cells by ct-Difluoromethylornithine, an Inhibitor of OrnithineDecarboxylase, and yV',A*-Bis(ethyl)spermidine, an Apparent
Regulator of the Enzyme. Carl W. Porter. Barbara Ganis, TimVinson, Laurence J. Marlon, Debora L. Kramer and RaymondJ. Bergeron.
Effect of Glucose on Systemic Hemodynamics and Blood FlowRate in Normal and Tumor Tissues in Rats. Donald J. DiPette,Kimberly A. Ward-Hartley and Rakesh K. Jain.
In Vitro Sensitivity of Normal and Hereditary RetinoblastomaFibroblasts to DNA-damaging Agents. William G. Woods andTimothy D. Byrne.
Mechanism of Interaction between Antineoplastic Agents andNatural Differentiation Factors in the Induction of Human Leukemic Cell Maturation. Yoshio Honma, Chieko Honma andAlexander Bloch.
Presence of Chromosomal Abnormalities and Lack of AIDS Ret-rovirus DNA Sequences in AIDS-associated Kaposi's Sarcoma.
Pasquale Delli Bovi, Emilio Donti, Daniel M. Knowles II, AlvinFriedman-Kein, Paul A. Luciw, DiñoDina. Riccardo Dalla-Favera and Claudio Basilico.
Relation of in Vitro Properties to Tumorigenicity for a Series ofSublines of the Human Breast Cancer Cell Line MCF-7. W.Barkley Butler, Pamela J. Berlinski, Roberta M. Hillman, WilliamH. Kelsey and Michele M. Toenniges.
Presence of Proteolytically Processed Keratins in the CultureMedium of MCF-7 Cells. Raymond Chan. Paul V. Rossitto,Benjamin F. Edwards and Robert D. Cardiff.
Growth-promoting Effect of 12-O-Tetradecanoylphorbol-13-ace-tate on Cultured Normal Human Fetal Kidney Epithelial Cells.Chia-cheng Chang, Ruth E. Gibson-D'Ambrosio, James E. Troskoand Steven M. D'Ambrosio.
Culture of Squamous Head and Neck Cancer on 3T3 Fibroblastsfollowing Isokinetic Velocity Sedimentation. Melody A. Cobleigh,John L. Kennedy. James H. Hill, Karin M. Lindholm, PatriciaW. Langenberg and Edward L. Applebaum.
Research. on January 26, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from
*6380 Heritable Variation in Expression of Multiple Tumor AssociatedEpitopes on a High Molecular Weight Mucin-like Antigen. PeterS. Linsley, Vincent Ochs, Diane Horn, David B. Ring and ArthurE. Frankel.
* 6400 Establishment of a Novel Acute Monoblastic Leukemia Cell Line(YK-M2) Having a Near-Triploid Karyotype. Hitoshi Ohno,Shirou Fukuhara, Shoichi Doi, Michihiko Yamasowa, Yuu Arila,Masataka Sasada, Yohichirou Ohno, Kiyoshi Akasaka and HarutoUchino.
* 6406 Differential Expression of Cell Surface Antigens and Glial I ¡brillar) Acidic Protein in Human Astrocytoma Subsets. Wolfgang J.Rettig, Pilar Garin Chesa, H. Richard Beresford. Hans-JoachimFeickert, Mark T. Jennings, James Cohen, Herbert F. Oettgenand Lloyd J. Old.
Carcinogenesis
6041 Development and Inheritance of Osmotic Tolerance in a Line ofSpontaneously Transformed BALB/3T3 Cells. Timothy L.Hennessey and Harry Rubin.
:':6064 Identification and Quantitative Determination of Aniline and To-luidines in Human Urine. Karam El-Bayoumy, Jean M. Donahue,Stephen S. Hecht and Dietrich Hoffmann.
:':61.1(i Increase in Human Exposure to Methylamine Precursors of N-Nitrosamines after Eating Fish. Steven H. Zeisel and Kerry-AnnDaCosta.
6149 Involvement of Protein Kinase C Activation in Ornithine Decar-boxylase Gene Expression in PrimaryCulture of Newborn MouseEpidermal Cells and in Skin Tumor Promotion by 12-O-Tetradec-anoylphorbol-13-acetate. Ajit K. Verma, Rey-Chen Pong andDeborah Erickson.
6160 Effect of Sodium Phénobarbitaland Sodium Saccharin in AIN-76A Diet on Carcinogenesis Initiated with W-|4-(5-Nitro-2-furyl)-2-thiazolyl|formamide and /V,/V-Dibutylnitrosaminein Male F344Rats. Katsumi Imaida and Ching Yung Wang.
6180 Inhibition of Junctional IntercellularCommunicationas a PossibleShort-Term Test to Detect Tumor-promotingAgents: Results withNine Chemicals Tested by Dye Transfer Assay in Chinese Hamster V79 Cells. Marco J. Zeilmaker and Hiroshi Yamasaki.
6200 Peroxidative Metabolism of a Carcinogen, /V-Hydroxy-/V-2-fluo-renylacetamide, by Rat Uterus and Mammary Gland in Vitro.Danuta Malejka-Giganti, Clare L. Ritter, Richard W. Decker andJean M. Suilman.
6246 Effect of Inhibitors of Ornithine Decarboxylase on RetrovirusInducedTransformation of Murine Erythroid Precursors in Vitro.S. Peter Klinken, Manuel J. Castilla and Snorri S. Thorgeirsson.
6290 Isolation and Characterization of a Chinese Hamster Ovary CellLine Resistant to Bifunctional Nitrogen Mustards. Craig N.Robson, Janice Alexander, Adrian L. Harris and Ian D. Hickson.
6349 Forestomach Lesions in Rats and Mice Administered 3-Chloro-2-methylpropene by Gavage for Two Years. Po C. Chan, Joseph K.Haseman, Gary A. Boorman, James Huff. Allan G. Manus andRichard H. Cardy.
6423 Induction of Prostate Carcinoma in Situ at High Incidence inF344 Rats by a Combination of 3,2'-Dimethyl-4-aminobiphenyl
and IviImi)I Estradiol. Tomoyuki Shirai, Shoji Fukushima, EtsuoIkawa, Yoshiaki Tagawa and Nobuyuki Ito.
6433 In Vitro Transformation of Primary Rat Trachea! Epithelial Cellsby 5-Azacytidine. Cheryl Walker and Paul Nettesheim.
Endocrinology*6116 Effect of Cytotoxic Drugs on Estrogen Receptor Expression and
Response to Tamoxifen in MCF-7 Cells. Robert Clarke, JanetMorwood. Hendrik W. van den Berg, John Nelson and RichardF. Murphy.
*6083
6111
*6174
*6187
*6236
6316
6322
*6369
*6393
*6413
*6446
*6029
*6034
*6169
*6217
6260
Immunology
Potentiation of Lymphocyte Responses by Monoclonal Antibodiesto the Ganglioside GDj.Peter Hersey, Stephen D. Schibeci, PhillipTownsend, Christine Burns and David A. Cheresh.
Effects of Concomitant and Sinecomitant Immunityon Postsurgi-cal Metastasis in Mice. Shinhachiro Nomi, Kazuyo Naito, BarryD. Kahan and Neal R. Pellis.
Implication of Chromosome 11 in the Suppression of NeoplasticExpression in Human Cell Hybrids. Eri S. Srivatsan, William F.Benedict and Eric J. Stanbridge.
Distinct Functional Domains on the RecombinantHuman ImmuneInterferon Molecule. M. Reza Ziai, Luisa Imberti, MichikoKobayashi, Bice Perussia, Giorgio Trinchieri and SoldanoFemme.
Inhibitory Effects of Elevated Temperature on Human CytokineProductionand Natural Killer Activity. Charles A. Dinarello, RoyA. Dempsey, Mark Allegretta, Gail LoPreste, Nicholas Dainiak,David R. Parkinson and James W. Mier.
Modulation of Cell Growth, Differentiation, and Production ofInterleukin-3 by la,25-Dihydroxyvitamin D3 in the Murine Mye-lomonocytic Leukemia Cell Line WEHI-3. Junko Abe, YoichiroMoriya, Motoo Saito, Yutaka Sugawara, Tatsuo Suda and YasuhoNishii.
Relationship between Expression of Tumor-specific Transplantation Antigens and Neoplastic Transformation in an UltravioletRadiation-induced Murine Skin Cancer. Honnavara N.Ananthaswamy.
Two Murine Monoclonal Antibodies against Human LungCancer-associated Antigens. Katsuyuki Endo, Hiroshi Kamma andTakesaburo Ogata.
Monoclonal Antibodies against Cell-Surface Antigens of the Met-astatic Rat 13762NF Mammary Adenocarcinoma and TheirCross-Reactivity with Human Breast Carcinomas. Susan M.North, Peter A. Steck and Garth L. Nicolson.
Enhancement by -y-Interferonof in Vivo Tumor Radiolocalizationby a Monoclonal Antibody against HLA-DR Antigen. GailRowlinson, Frances Balkwill, Deborah Snook, George Hookerand Agamemnon A. Epenetos.
Membrane-associated Glycoprotein (gpl60) Identified on HumanLung Tumors by a Monoclonal Antibody. Samuel Zylstra, Fang-An Chen, Swapan K. Ghosh, Elizabeth A. Repasky, Uma Rao,Hiroshi Takita and Richard B. Bankert.
Molecular Biology and Genetics
Detection of Activated M, 21,000 Protein, the Product of rasOncogenes, Using Antibodies with Specificity for Amino Acid 12.Gail Wong, Norman Arnheim, Robin Clark, Peter McCabe,Michael Innis, Lois Aldwin, Danute Nitecki and FrankMcCormick.
Cloning of Estrogen-regulated Messenger RNA Sequences fromHuman Breast Cancer Cells. Felicity E. B. May and Bruce R.Westley.
Enhanced Levels of Insulin-like Growth Factor Messenger RNAin Human Colon Carcinomas and Liposarcomas. James V. Tricoli,Leslie B. Rail, Constantine P. Karakousis, Lemuel Herrera,Nicholas J. Petrelli, Graeme I. Bell and Thomas B. Shows.
Enhanced Expression of the N-myc Gene in Wilms' Tumors. Perry
D. Nisen, Kathryn A. Zimmerman, Sean V. Cotter, Fred Gilbertand Frederick W. Alt.
Inhibition of Dimethyl Sulfoxide Induced Erythropoietic Differentiation of Murine Erythroleukemia Cells in Culture. MagdaForesti, Luciano Gaudio, Giuseppe Ceraci and Paola Manduca.
Continued
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*6295 Enhanced Expression of the c-myc Gene in Bovine LeukemiaVirus-induced Bovine Tumors. Phalguni Gupta, S. V. S. Kashmiri,M. D. Erisman, P. G. Rothberg, S. M. Astrin and J. F. Ferrer.
*6327 Terminal Erythroid Differentiation in the K-562 Cell Line by 1-/3-D-Arabinofuranosylcytosine:Accompaniment by c-myc Messenger RNA Decrease. G. L. Bianchi Scarrà ,M. Romani, D. A.Coviello, C. Carré,R. Ravazzolo, G. Vidali and F. Ajmar.
6427 Microinjection of the ras Oncogene Protein into NonestablishedRat Embryo Fibroblasts. Neil F. Sullivan, Raymond W. Sweet,Martin Rosenberg and James R. Feramisco.
Preclinical Pharmacology and Experimental Therapeutics
6024 DNA Damage in Cultured LI 210 Cells by 2-Haloethyl Esters of(Methylsulfonyl)methanesulfonic Acid. Jo Ann Alexander,Bonnie J. Bowdon and Glynn P. Wheeler.
* 6091 Comparison of the Effects of an Ornithine Decarboxylase Inhibitor on the Intestinal Epithelium and on Intestinal Tumors. PeterJ. M. Tutton and David H. Barkla.
*6101 Pharmacokinetics of Intraventricularand Intravenous N,N',N"-
Triethylenethiophosphoramide (Thiotepa) in Rhesus Monkeysand Humans. John M. Strong. Jerry M. Collins, Cynthia Lesterand David G. Poplack.
6105 Quantitative Analysis of Cellular Glutathione by Flow CytometryUtilizing Monochlorobimane: Some Applications to RadiationandDrug Resistance in Vitro and in Vivo. Glenn C. Rice, Edward A.Bump, Dennis C. Shrieve, William Lee and Mary Kovacs.
6125 Effects of 7-A-O-Methy Inogarol(Menogaril) on LI 210 Cell Progression in Vitro and in Vivo. Earl G. Adams and Bijoy K.Bhuyan.
*<>I56 m-Diaimninedichloroplatinum(II)-induced Sister <'hruinâtid Ex
change: An Indicator of Sensitivity and Heterogeneity in PrimaryHuman Tumor Cell Cultures. Philip J. Tofilon, Charlotte M.Vines, Fraser L. Baker, Dennis F. Deen and William A. Brock.
*(.I9I Alteration of Fluorouracil Metabolism in Human Colon CancerCells by Dipyridamole with a Selective Increase in Fluorodeox-yuridine Monophosphate Levels. Jean L. Grem and Paul H.Fischer.
6223 Experimental Radioimmunotherapy of Murine Lymphoma withIMI-labeled Anti-T-Cell Antibodies. Christopher C. Badger,
Kenneth A. Krohn. Howard Shulman, Nancy Flournoy and IrwinD. Bernstein.
6229 Temperature Measurements in Normal and TumorTissue of DogsUndergoing Whole Body Hyperthermia. Donald E. Thrall,Rodney L. Page, Mark W. Dewhirst, Robert E. Meyer, P. JackHoopes and Joe N. Kornegay.
6242 Hyperthermic Potentiation of m-Diamminedichloroplatinum(II)Cytotoxicity in Chinese Hamster Ovary Cells Resistant to theDrug. Kent E. Wallner, Michael W. DeGregorio and Gloria C.Li.
6250 Water-soluble yV-substituted Iminodiacetato(l,2-diaminocyclo-hexane)-platinum(II) Complexes as Potential Antitumor Agents.M. P. Hacker, A. R. Khokhar, I. H. Krakoff, D. B. Brown andJ. J. McCormack.
* 6264 Enhanced Inhibition of Colony Formation of Human Renal CellCarcinoma in Soft Agar by the Combinationof a-Difluoromethyl-ornithine and Recombinant f-Interferon. Kazuo Gohji, Shin-ichiMurao, Sakan Maeda, Taketoshi Sugiyama and Sadao Kamidono.
6269 Toxicity and Antitumor Activity of cis-Bis-cyclopentenecarboxyl-ato-l,2-diaminocyclohexane Platinum(II) Encapsulated in Multi-lamellar Vesicles. R. Perez-Soler, Abdul R. Khokhar, M. P.Hacker and G. Lopez-Berestein.
*6274
*6286
6387
6456
6462
6471
6475
6481
6489
6494
6503
6509
6513
6520
(ïilnimlulmAntagonism and Growth-inhibiting Activity of Tri-phenylethylene Antiestrogens in MCI--7 Human Breast CancerCells. Alberto Gulino, Giuseppina Barrera, Alessandra Vacca,Antonietta Farina. Carlo Ferretti, Isabella Screpanti, Mario U.Dianzani and Luigi Frati.
Modulation of Thiopurine Cytotoxicity in the III -6(1Cell Line byPhysiological Concentrations of Hypoxanthine. Solomon Zimm.Gloria E. Johnson and David G. Poplack.
A New Concept for Macrontolecular Therapeutics in CancerChemotherapy:Mechanism ot"IumoritrupieAccumulationof Pro
teins and the Antitumor Agent Smancs. Yasuhiro Matsumura andHiroshi Maeda.
CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS
Clinical
Characterization of Malignant Peripheral Blood Cells of Juvenile Chronic Myelogenous Leukemia. Zeev Estrov, BarryZimmerman, Tom Grunberger, Judy Chao, Ikuko E. Teshima,Helen S. Chan and Melvin H. Freedman.
Phenotypic Characterization of Lung Cancers in Fine NeedleAspiration Biopsies Using Monoclonal Antibody B72.3. WilliamW. Johnston, Cheryl A. Szpak, Ann Thor and Jeffrey Schlom.
Cancer Procoagulant in Human Tumor Cells: Evidence from Melanoma Patients. Maria Benedetta Donati. Carlo Gambacorti-Passerini, Bruno Casali, Anna Falanga, Paola Vannotti, GiuseppeFossati. Nicola Semeraro and Stuart G. Gordon.
Histochemical Studies with an Estrogen Receptor-related Proteinin Human Breast Tumors. Antonio Cano. Arnold I. Coffer, RemyAdatia. Rosemary R. Millis, Robert D. Rubens and Roger J. B.King.
Correlations between Immunological Phenotype and Karyotype inMalignant Lymphoma. Ellis G. Levine. Diane C. Arthur,Kazimiera J. Gajl-Peczalska, Tucker W. LeBien. Bruce A.Peterson. David D. Hurd and Clara D. Bloomfield.
Development of Primary and Secondary Immune Responses toMouse Monoclonal Antibodies Used in the Diagnosis and Therapyof Malignant Neoplasms. Nigel S. Courtenay-Luck, AgamemnonA. Epenetos. Richard Moore. Mark Lärche,Dimitris Pectasides,Babu Dhokia and Mary A. Ritter.
Preoperative Imaging of Colorectal Carcinoma with '"In-labeled
Anticarcinoembryonic Antigen Monoclonal Antibody. J. DavidBeatty, Rosemary B. Duda, Lawrence E. Williams, KhalilSheibani, Raymond J. Paxton. Barbara G. Beatty, Vicki J.Philben. John L. Werner, John E. Shively, William G. Vlahos,William A. Kokal, Daniel U. Riihimaki, Jose J. Terz andLawrence D. Wagman.
Testis Imaging with '"In-labeled Anticarcinoembryonic Antigen
Monoclonal Antibody:Identificationof CarcinoembryonicAntigenin Normal Germ Cells. BarbaraG. Beatty. Raymond J. Paxton,Khalil Sheibani, Rosemary B. Duda, Lawrence E. Williams, JohnE. Shively and J. David Beatty.
Incorporation of lododeoxyuridine into DNA of Granulocytes inPatients. Karl Belanger. Raymond W. Klecker, Jr., Jan Rowland,Timothy J. Kinsella and Jerry M. Collins.
Development of an Assay System for the Detection and Classification of Methotrexate Resistance in Fresh Human LeukemicCells. Sjoerd Rodenhuis. John J. McGuire, RamaswamyNarayanan and Joseph R. Berlino.
Purification, Partial Characterization, and Clinical Evaluation ofan Adenocarcinoma-associated Antigen. Valerian B. Pinto, FrankB. Gelder and Don M. Morris.
Continued
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Epidemiológica! 6525 Announcements
6452 Effects of a-Naphthoflavone on Levels of Sister Chromatid Ex- 6526 Erratumchanges in Lymphocytes from Active and Passive Cigarette Smok- J. A. Milner et al., 45: 6347-6354, 1985.ers: Dose-Response Relationships. Owen W. Coliman, Karaten ¿,ii •, , , •»„. ., „, „, ... T, , ' ... 6527 Acknowledgment to ReviewersLundgren, David Shore, Claudia L. Thompson and George W.Lucier. 6536 Author Index
Beginning January 1987, Cancer Research will be published twice a month. Issues will be numbered from 1 through 24 and dated the 1st and 15th dayof each month. All of the subject categories covered by the journal will be represented in every issue.
NOTE: Advance registration form for 78th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.
Research. on January 26, 2021. © 1986 American Association for Cancercancerres.aacrjournals.org Downloaded from
1986;46:6019-6535. Cancer Res 46 (12 Part 1)
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