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www.erythron-lab.com
ACOGSOCGCCMGNICE
1 the American Congress of Obstetricians = ACOG 2 - The Society of Obstetricians and Gynecologists of Canada (= SOGC) 3 - Canadian College of Medical Genetics (=CCMG) 4 - the UK National Institute for Health and Clinical Excellence (=NICE)
5 - Open Neural Tube Defects (=ONTDs) 6 - efficient
NT
1 - cost effecitvie
ACOG
MoMsMoM
MoM
MoMs
AFP
AFPAFP
1 - Multiple of Median (=MoM) 2 - Median 3 - Radio Immuno Assay (=RIA) 4 - ELISA
MoMs
MoM
MoM
OAPR
OAPR
nOAPR
OAPR
OAPR
PAPP-AhCGFree(NT)
(11W+0D)(13W+6D)
12W+0D13W+3D
1 - Odds of being Affected given a Positive Result (=OAPR)
2 - Positive Predictive Value (=PPV)
3 - First Trimester Screening (=FTS)
PAPP-AhCGFree
(NT)
NT
OSCAR
4 - One Stop Clinic for Assessment of Risk (=OSCAR)
OAPR
(11W+0D)
MoMs
MoMs
CVS
NT
1 - Mahalanobis distance 2 - screen positive 3 - Chorionic Villus Sampling (=CVS) 4 - fetal transverse limb abnormality 5 - micrognathia 6 - microglossia
7 - exomphalos 8 - ossification
NT
CRL
(13W+6D)
NT
NT
NT
NTNT
NT
CRL
1 - nuchal edema 2 - Nuchal Translucency (=NT) 3 - transabdominal 4 - transvaginal 5 - Crown Rump Length (CRL)
NTNT
NT
NTCRL
CRL
NT
NT
NT
NT
NT
NT
6 - mid - sagital 7 - Neutral 8 - flexed position 9 - hyperextended position 10 - Calipers 11 - inner to inner
NT
NT
NT
NTNT
NT
BCPGSPNT
NT
NTNT
45.XOX
NT
NT
NTNT
CRLCRL
NT
NT
NT
NT
1 - BC Prenatal Genetic Screening Program (=BCPGSP)
2 - skeletal dysplasia
PAPP-A
PAPP-A
IGF
IGFIGF
hCGFreehCG
hCGFreehCG
hCG
(high risk)
(borderline risk)
1 - insulin growth factor (=IGF) 2 - Chorionic Villus Sampling (=CVS) 3 - sequential
(low risk)
AFPAFP MoMNTDs
NT
NT
NT
BCPGSP
4 - translocation 5 - deletion 6 - insertion 7 - inversion 8 - unbalanced chromosomal complement
PAPP-A MoM Free hCG MoMNT MoM
HIV
HIV
IVFICSI1
AFPhCGuE3Inhibin A
1 - Intra Cytoplasmic Sperm Injection(=ICSI)
(14W+0D)
(22W+6D)
15W+2D17W+0D
(AFP)AFP
AFP
(hCG)hCG
mIU/ml
mIU/mlhCG
(uE3)uE3
(DIA) Inhibin AInhibin A
AB
hCGInhibin AAFPuE3
NTPAPP-A
NT
NT
1 - integrated tests 2 - serum integrated 3 - non - discloser
NT hCG
Free PAPP-A
(high risk)
LMP
4 - independent 5 - stepwise 6 - contingent
AFP MoM hCG MoMuE3 MoMInhibin A MoM
IUGR
AFP)2.5(MoMhCG)3.0(MoM
Inhibin A)3.0(MoMuE3).40(MoM
(low risk)
(high risk)
IUGR1
LMP
(low risk)
1 - Intra Uterine Growth Restriction (= IUGR) 2 - choroids plexus
(NTDs)
AFP
NT
AFPhCGPAPP-A
Inhibin AAFP
1 - false positive rate 2 - ethnic origin
hCGPAPP-AuE3
NT
(IDDM)
AFPuE3
hCGFree
PAPP-A NT
IVFhCGuE3
AFPInhibin AIVFhCG
PAPP-ANThCGFree
BCPGSP
1 - prior risk 2 - likelihood ratio 3 - isolated echogenic cardiac focus 4 - echogenic bowel 5 - soft markers
CSF
NF
IUGR
6 - nuchal thickness 7 - renal calyceal dilation 8 - cystic hygroma 9 - clinodactyly 10 - duodenal atresia 11 - hypopastic or absent mid phalanx of the fifth digit 12 - sandal gap 13 - abnormal wave in ductus venosus 14 - cisterna magna 15 - Cerebro Spinal Fluid (=CSF) 16 - facial cleft 17 - single umbilical artery 18 - overlapping fingers 19 - rocker bottom feet
1 - holoprosencephaly 2 - syndactyly 3 - hithch hiker toe deformity
MoMNT
hCG MoM
NTDs
AFP
4 - hypetelorism 5 -hypotelorism 6 - anoophtalmia 7 - cleft lip / cleft palate 8 - open neural tube defects 9 - open spina bifida 10 - myelomeningocele 11 - encephalocele
Quad
Screen
First Trimester Combined
Screen
Serum Integrated
Screen Full Integrated
Screen Sequential
Screen
NTDs
AFP , HCG, UE3 , DIA
NT , PAPP-A , FBHCG
PAPP-A , AFP , HCG , UE3 , DIA
NT , PAPP-A , AFP HCG , UE3 ,
DIA
NT PAPP-A , FBHCG , AFP ,
HCG , UE3 , DIA
Quad Screen
First Trimester
Screen
Serum Integrated
Screen
Full Integrated
Screen Sequential
Screen
AFP
SLO
1 - closed NTDs 2 - lipomyelomeningocele 3 - lipomeningocele 4 - tethered cord 5 - Smith Lemli Opitz
SLO
uE3
MoMMoMs
SLOSLO
SLO
NTDs
NT
PAPP-A0.4MoM0.5MoMhCG
Free
1 - microphthalia 2 - anophthalmia 3 - Peter anomaly
IUGR
IUFD
IUGR
PAPP-A
hCGFree
hCGFree
XhCGFreePAPP-A
(MoM<0.25) PAPP-A
IUGR
PAPP-A
4 - Intra Uterine Fetal Death (= IUFD) 5 - abnormal maternal uterine artery Doppler 6 - impaired placental function 7 - small for gestational function 8 - Spencer
(MoM>2.0) PAPP-A
PAPP-AhCGFree
AFPAFP
NTDs
AFP
AFP MoMAFP MoM
AFP
AFP MoMuE3 MoM
1 - spontaneous reduction 2 - vanishing twin 3 - fetal structural anomalies 4 - ventral or abdominal wall defects 5 - gastroschisis 6 - omphalocele 7 - teratoma 8 - Cystic hygroma
AFPAFP
AFP MoM
AFP
AFP
AFP MoM
AFP MoM
AFPAFP
AFP
AFP MoM
hCG
(MoM>3.0)
IUGR
AFP
AFP
AFP
(IUGR)
AFPHCG
MoM>2.5MoM<0.5
AFP
IUGRAFP
IUFD
1 - choriocangioma 2 -choriocarcinoma 3 - Preterm Rupture of Membranes (=PROM) 4 - preterm delivery or labor or birth 5 - low birth weight 6 - Katz 7 - Haley 8 - abruption placenta 9 - oligohydroamnious
AFP
AFP
AFP
AFP
IUGR IUFD
AFP MoM
AFP
(MoM<0.25) AFP
AFP
10 - antepartum bleeding 11 - prematurity 12 - uterine artery Doppler 13 - transabdominal multifetal reduction 14 - macrosomia 15 - placenta previa 16 - placenta accrete 17 - placenta increta
AFP
AFP
AFP
AFP
AFP
hCG
hCG
hCG
hCG
(MoM=>3.0) hCG
IUGR
1 - placenta percreta 2 - morbidity 3 - asphyxia 4 - sudden infant death syndroma 5 - maternal hypertension or pregnancy induced hypertension
hCG MoM
hCG MOM
HELLP70 IU/L
hCG(MoM 2.0-4.0)
IUGRLBW
hCG
hCGIUGR
hCG
6 mole hydatiform 7 - Walton 8 - hemolysis , elevated liver enzymes and low platelets 9 - Fragmin
hCGAFP
hCG
hCG
B12
hCG
(MoM < 0.5) hCG
hCGAFP
AFPhCG
HIVCD4
uE3(MoM<0.3)
uE3(MoM<0.5)X
1 - non immune hydrops 2 - protease inhibitors intake 3 - X- linked Ichtyosis
Rh
IUGR
uE3LBW
uE3
Inhibin AInhibin A(MoM>2.5)
Inhibin AIUGRIUFD
Inhibin A
(MoM > 2.8) Inhibin A
Inhibin AHELLP
4 - congenital adrenal hyperplasia (=CAH) 5 - oligohydramnios 6 - steroid sulfatase deficiency 7 - placental aromatase deficiency 8 - uterine artery notching
AFP
(MoM>2.5)hCG(MoM>3.0)Inhibin-A (MoM>3.0)AFP
(MoM>0.25)uE3(MoM<0.5)
REFERENCES
1. Nicolaides KH. Am J. Obstet. Gynecol. 2004; 191 : 45-67. 2. Chitayat D, and et al. JOGC July 2011, 261: 736-50. 3.Buckley F and et al. Down Syndrome Research and Practice. Oct. 2008, 12 (Issue 2): 79-86. 4. Taheri Amin MM, et al. Gamete Scientific Bulletin. Vol 8, No.23 & 15, Summer 2010. 5. Taheri Amin MM, et al. Gamete Scientific Bulletin. Vol 4 , No. 12 , Spring 2007. 6. Taheri Amin MM, et al. Eighth International Congress of International Down s Syndrme Screening Group. (Oral Presentation), Vancouver, Canada, May 2008. 7. pandya PP, and et al. BJOG 1995; 102: 957-62. 8. Cuckle HS, et atl. Ultrasound Obstet. Gynecol. 2007: 19 (4): 323-6. 9. Taheri Amin MM, et al. Sixth International Congress of Fetal Medicine. (Oral Presentation), Cavtat, Croatia, July 2007. 10. Taheri Amin MM, et al. Seventh Internaltional Congerss of International Down s Syndrome Screening Group. (Oral presentation), Amsterdam, Netherlands, May 2006. 11. Spencer K, et al. Prenatal Diagnosis. 2000; 20, 91-5. 12. Hackshaw AK, and et al. Prenatal Diagnosis. 2001; 21, 58-61. 13. Snijders RJM, and et al. Lancel 1998 ; 351:343-6. 14.Dugoff L, et al. Obstet Gynecol, 2005 Aug. 106 (2): 260-7. 15. Gagnon A, et al. JOGC Oct. 2008; 217: 918-32. 16. Hasegawa J, et al . Taiwan J. Obstet. Gynecol, 2006 March; 45 (1) : 21-5. 17. Palomaki GE. Adv. Clin. Chem. 2007; 43: 177. 18. Spencer K. Prenat Diagn, 2008: 28: 7. 19. Karsidag AYK, et a.. JPMA, 2010; 10: 13-5. 20. Dugoff L, et al. Obstet. Gynecol. 2010 May; 115(5): 1052-61. 21. Gagnon A, et al. JOGC Oct. 2008; 217: 918-32. 22. Huang T, et al. Prenat. Diagn. 2010 May; 30 (5): 471-7.
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