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Chronic Myeloid Leukemia
Brian Druker, MD
Prince Mahidol Award Conference
February 1, 2019
Friday, February 1, 19
• 15 - 20 % of all leukemias
Average age of onset - 50 to 60 yrs of age
Median survival – 3 to 5 years
• 1 - 2 cases per 100,000 per year
Chronic Myeloid Leukemia (CML)
Friday, February 1, 19
Friday, February 1, 19
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BCR-ABL As a Therapeutic Target for CML
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STI571 (CGP 57148B) Imatinib mesylate
GleevecTM, Glivec®
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CML Summary
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CML Summary
• There are currently 5 drugs on the market that target BCR-ABL
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CML Summary
• There are currently 5 drugs on the market that target BCR-ABL
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CML Summary
• There are currently 5 drugs on the market that target BCR-ABL
• Survival has been significantly prolonged
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CML Life Expectancy
Boweretal,JClinOnc34:2851-7,2016
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Since 2009 we have been working with the premise
“The improved survival in CML… is so dramatic that these new agents must be made available... As rapidly as possible throughout the whole world.”
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As we look to the future
CML is predicted to become the most prevalent leukaemia by 2040 when there are projected to be over 3 million patients worldwide.
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Global programs impact CML education, access to diagnostics and therapy
Enhancing patients survival around the world
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Ourmissionistoincreaseglobalaccesstotreatment,careandsupportforpeoplelivingwithcancer.
InmemoryofMaxRivarola,1973-1991
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The Max Access Solution ModelA patient centered system of humanitarian access to oncology treatment
HEALTHCAREPROVIDERSAnapprovednetworkofcancerspecialists
TREATMENTACCESSProcurementofqualitytargetedtreatment
LOGISTICS&DISTRIBUTIONEndtoendvalidated
supplychain
PATIENTSUPPORTAsupportsystem
aroundthepaMent
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Max Access Solution for CML
72countries
30,000CML patientson treatment
600physicians
70Patient
associations3distribution
centers
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