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Quantitative lung scintigraphy and spirometry in bronchogenic carcinoma. Beyer-Enke SA, Strauss LG. Goerich J, Clorius JH. German Cancer Research Center.Insritutefor RadiologyandPathophysiology, D-6900 Heidelberg. NUC Compact 1988;19: 160-5.

Tumor size, location, scintigraphic and spirometric data were evalu- ated in 80 patients suffering from squamous cell carcinoma. Perfusion, ventilation, washout data, as well as vital capacity and forcedexpiratory volume in 1.0 set showed decreasing values with more proximal bronchial obstruction. A statistically significant inversecorrelation was found between tumor diamctcr and ventilation data in peripheral and central tumors. Washout data increased with tumor size in masses with peripheral location. Spirometric data were reduced in all patients regardless of tumor size and location. We were able to demonstrate that the quantitative evaluation of scintigraphic images can be used for accuralcasscssmcntofbochpostoperativelungfunctionandoperability.

plasma and tissue concentrations of S-FU, uracil and m-207 were examined in patients with lung cancer. Higher plasma concentrations of 5-FU and uracil were observed in the patients who were given warfarin and ticlopidine beforehand, whereas the concentrations of FT-207 were almost~esameinthepatientswhoweregivenanticoagulantsasinthose who were not. This may be interpreted as an inhibition of dihydrouracil dehydrogenase, the common metabolizing enzyme of 5-FU and uracil, by anticoagulants. With regard to the tissue concentrations, higher levels of 5-FU and uracil in the tumor and lymph nodes were obtained after anticoagulants were given beforehand. Concentrations of FT-207 in thcsc tissues, however, were almost the same in the patients who were given anticoagulants as in those who were not. We thus concluded that anincreaseof5-FUin tumorcellsandlymph nodescan beachievedafter elevating the plasma concentrations of ordinary oral doses of UFT by using anticoagulation therapy beforehand.

Circulating antineural antibodies - Using a paraneoplastic phe- nomenon as tumour marker in small-cell bronchial carcinoma. Popp W, Drlicek M, Grisold W, Zwick H. Lungenabteilwg, Kranken- haus Wien-Lainz, A-1130 Wien. Prax Klin Pneumol 1988;42:665-7.

A neuron specific antibody was indentified via immunofluorescent test in the serum of I8 out of a total of 45 patients having a small-cell bronchial carcinoma. The identification of the antibodies was effected at the nuclei of nerve cells (the nucleoli being spared, i.e. left out during the test) and, to a slight extent, in the cytoplasm. The antineuronal antibodies were classified in 14 cases as immunoglobulin G and in 4 cases as immunoglobulin M. No reaction was found against other non- neuronal structures. No circulating antineuronal antibodies were iden- tified in control groups withb 73 non-small cell bronchial carcinomas, 2 I metastatic lung diseases with otherprimary turnours, 16 infectious or other immunological diseases and I5 healthy control persons. Hence, the antineuronal antibody described here - which is also associated with neurological paraneoplastic diseases in small-cell bronchial carcinoma - is a highly s&ific p&meoplastic phenomenon in small-cell bronchial carcinoma that can be used as a tumour marker.

Tumor markers in chronic obstructive airway disease (COAD) in relation to bronchial carcinoma. Ali Khalifa A, Mahmoud Ismail H, Gomaa A, El Ahmady 0, Khalid H, Mohamcd Reda H. Biochemistry Department, Oncology Diagnostic Unit, Faculty of Medicine, Ain Shams University, Cairo. J Tumor Marker Oncol 1988;3: 187-91.

The serum levels of CEA, AFP, TPA, CT & NSE were estimated in 40 patients with chronic obstructive airway disease (COAD), 42 newly diagnosed histologically proved bronchial carcinoma and 22 healthy subjects. The bronchial carcinoma group included 8 SCLC, 20 squamous ccl1 carcinoma, 10 adenocarcinoma and 4 large cell carci- noma. The sensitivity of CEA as a tumor marker is increased from 76% to 90.5% by combination with TPA. Further addition of NSE increased sensitivity to 95.2%. For SCLC the sensitivity of NSE is 75% as compared to 14.28% in cases of NSCLC. We concluded that CEA, TPA and NSE arc excellent combination markers assay for assessment in bronchial carcinoma.

Emergency computerized tomography oftracbeoesophageal fistula in lung adenocarcinoma. Smulewicz JJ, Guerrero LE. Washington D, Hassani SN. Department of Clinical Radiology, Harlem Hospital Center, New York, NY 10037. J Natl Med Assoc 1988;80:817-21.

Plasma immunoreactive calciotropic hormone-like substances as markers of bronchogenic carcinoma. Fran&i G, GennarC. Institute of Medical Semiotics, Division of Clinical Oncology, University of Siena, 53100 Siena. J Tumor Marker Oncol 1988;3:179-86.

Malignant trachcoesophageal fistula occurs infrequently in patients with irradiated esophageal and lung cancer, uncommonly in patients with untreated mediastinal malignancies, infection, or trauma, and rarely in primary adenocarcinoma of the lung. The natural progression of this entity leads to rapid deterioration and death from overwhelming pulmonary infection. Definitive treatment depends on the demonstra- tion and localization of the fistula. Computerized tomography (CT) chest scanning with dilute oral contrast is the ideal means of identifica- tionofthe fistula.CTscanning withoutcontrastmayoutlinesufficiently the pathology to avoid the usage and side effects of contrast media in the lungs. A review of one case of tracheoesophagcal fistula due to pulmonaryadenocarcinomaispresentcd WhereemergencyCTscanning without contrast resulted in rapid and accurate diagnosis, leading to prompt and appropriate management.

Plasma levels of immunorcactive parathormone (iPTH) and im- munorcactive calcitonin (iCT) were measured by RIA in 231 patients with bronchogenic carcinoma. High serum levels of these hormone-like substances were found and the levels varied in some cases according to the clinical evolution of the disease and the response to therapy.

Simultaneous serum and bronchial fluids marker determination in primary lung neoplasms. Clerici M, Pollice P, Montinari F et al. Medical Oncology Department, S. Carlo Borromeo Hospital, 20153 Milan. J Tumor Marker Oncol 1988;3: 175-8.

We tested the usefulness, as diagnostic markers, for Small Cell (SC) and Non Small Cell (NSC) lung cancer of NSE, CEA, TPA, CKBB and Calcitonin: bronchial fluid and serum determinations were performed. Fluids were obtained by washing during bronchoscopy; as well as samples for hystological and cytological examination. Markers deter- minations were carried out with RIA method. Since 1st Feb. 1987 we studied 47 patients: histology prooved 9 epidermoids carcinomas, 12 adeno, 16 SC, 5 non neoplastic acute flogosis, and 6 chronic non neoplastic disease. NSE elevated levels in bronchial fluids and in serum were founded especially in SC and adenocarcinoma patients, with no cases of fluids-positivity with negative serum. Utilization of bronchial fluid for markers determinations seems not to be of any advantage in comparison with routine diagnostic tools.

Interactions between UFT and anticoagulants in lung cancer pa- Gents. Ogawa J, Inoue H, Tsurumi T, lnoue H, Koide S, Kawada S, Shohtsu A. The First Department of Surgery. Tokai University School of Medicine, Kanagawn 259-21. Jpn J Surg 1988:18:243-51.

In order to study the interactions between UFf and anticoagulants, the