Mupirocin reduces ciliary beat frequency of human nasalepithelial cells

Article in Archiv für Klinische und Experimentelle Ohren-Nasen- und Kehlkopfheilkunde 273(12) · June 2016 with 9ReadsDOI: 10.1007/s00405-016-4161-8

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Abstract

Mupirocin is used worldwide for topical treatment ofinfected skin lesions, impetigo, and especially fornasal decolonization of patients with carriage ofStaphylococci, including methicillin-resistantStaphylococcus aureus. Nevertheless, data

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Richard Birk25.48 · Universität Heidelberg

Christoph Aderhold25.61 · Universität Heidelberg

+ 4Angela Wenzel25.82 · Universitäts…

Till Eschenhagen7.25 · Universitätsmedizin Mannheim

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regarding the effects of mupirocin on the nasalmucosa, in particular on ciliary beat frequency(CBF), is lacking to date. We tested the CBF ofciliated nasal epithelial cells under the influence ofMupirocin–calcium dissolved in tert-butyl alcohol(TBA) containing media in different concentrationscomparable to clinical use. Ringer’s lactate solutionand TBA served as negative control. Cells werevisualized with a phase contrast microscope, andthe CBF was measured with the SAVA system’sregion of interest method. Mupirocin–calciumdissolved in TBA led to a statistically significanttime- and concentration-dependent decrease inCBF compared to the negative control. TBAaddition without mupirocin also led to a significantdecrease in CBF, although to a lesser extent thanmupirocin/TBA. In conclusion, CBF of human nasalepithelia is significantly reduced by mupirocin–calcium-containing solutions in therapeuticconcentrations. Due to our results in this study,mupirocin as a nasal decolonization agent shouldbe used only with care, with a strictly set medicalindication, and additional care measures should beconsidered.

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