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    CLERKSHIP REVIEW-I

    By :-Avinash

    Pharm.D 5thyr

    Roll no-1414907

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    GENERAL MEDICINE

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    Contents

    Drug Information Queries

    Patient prole

    Drug Interactions Patient counseling

    Case presentation

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    DRUG INFORMATION QUERIES

    se of !opical Anest"esia

    Lumpectom#

    Mec"anical $al$e $s %ioprost"atic $al$e

    Causes of Dia&etic Retinopat"#

    !reatment of cellulitis

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    PATIENT PROFILE

    Acute gastroenteritis with Anemia Liver Abscesses Generalized weakness Chronic Kidney Disease with DM-II with !" with Anemia

    Le#t leg in$ury Diabetes mellitus-II with y%ertension Insect bite C&'D with Atrial (ibrillation y%ertension with DM-II

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    DRUG INTERACTIONS Case'(

    ) *+o,acin-*nansteron Case'/

    ) Aspirin-Insulin Case'0 )abe%razole*iron

    Case'1

    ) Pantopra2ole-Rifa,imine Case'3

    ) !ramaol-P"en#lnep"rine) Metronia2ole-Diclofenac) Diclofenac-Ami4acin

    Case'5) !elmisartan-6urosemie) Ceftria,one-6urosemie

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    PATIENT COUNSELLING

    A&out Life st#le moication

    A&out Disease an Drugs

    +ene#its o# the com%letion o# the !hera%y

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    CASE PRESENTATIONON

    Chroni Ki!ne" Dise#seWith Di#$etes %e&&it's

    With H"(ertension

    With Ane%i#

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    De%o)r#(his

    I'D "o-,./012,

    Age - / yrs

    3e4 5 (emale

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    Re#sons *or A!%ission

    c.o) Decreased #re6uency o# micturation since 7 days8

    ) 'ain in abdomen8

    ) 'al%itation since 7days8

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    HOPI

    'atient was a%%ro%riately well 7 days back whenshe develo%ed %ain in abdomen8

    Loose stools #or which she took medication8 Decrease in #re6uency o# micturation8 Always sweating8

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    P#st Me!i#& Histor" .&

    ) Diabetes mellitus since 7yr) y%ertension since 9yr

    P#st Me!i#tion Histor" 'atient was on oral hy%oglycemic agents

    ) Met#ormin * glimi%ride * %ioglitazone) 'atient was on Antihy%ertensive drugs

    ) Amlong * hydrochlorthiazide

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    Person#& Histor" Married

    :egetarian

    F#%i&" Histor"

    "o .& similar com%laint / children; all normal

    Soi#& Histor" "on smoker "on drinker

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    PROVISIONAL DIAGNOSISDiabetes mellitus-II

    y%ertensionAnemia

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    L#$or#tor" Re(orts

    He%#to&o)" DLC

    ) %olymor%hs 08>>-08>>?) Lym%hocytes ,1= 9>8>>-/>8>>?) @osino%hills >7 98>>->?

    ) Monocytes >9 98>>-,>8>>?) +aso%hils >> >8>>-,8>>?

    b 281= ,98>>-,8>>g? @3) /2= >8>>-9>8>>mm.,sthr !LC ,97>> = />>>-,>>>>.mm )+3

    ) )andom blood sugar 97,80= 0>8>-,,>8>mg.dl

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    Ren#& F'ntion Test +RFT,) Brea 2,8>/= ,8>>-/>8>>?) Creatinine >890 = >8/>-,8/>mg.dl) 3odium ,7< ,7-,/[email protected]) 'otassium 78,= 78>-8>>[email protected]) Chloride ,>, 1

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    Lier F'ntion Test +LFT, +ilirubin !otal 98/> = >89> - ,8>>mg.dl +ilirubin Direct ,80>= >8,> 5 >87>mg.dl 3G&! /787>= 8>> 5 />8>>IB.L 3G'! 978,> 8>> 5 78>>IB.L Alkaline 'hos%hatase 9,08/= 8>> 5 ,,98>>IB.L

    Li(i! Pro*i&e !otal Cholesterol ,8> 5 9>>8>mg.dl !riglyceride 1782 ,>mg.dl DL />8> 7>8> 5 0>8>>mg.dl LDL ,>8 5 ,1>8>mg.dl

    :LDL ,/280< 8>> 5 78>>mg.dl

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    Urine R.E

    :olume 7>ml Color %ale yellow Brine albumin traces Brine sugar #asting nil )+Cs occasional 'B3 cells /-.'(= @%ithelial cells 7-/.'( Crystals nil Casts nil

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    Wi!#&

    3almonella !y%hi E&F ,/> 3almonella !y%hi EF ,/> 3almonella !y%hi EAF neg

    3almonella !y%hi E+F neg

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    FINAL DIAGNOSISChronic Kidney Disease

    Diabetes mellitus-IIy%ertension and

    Anemia

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    D#"-/

    &.@- calm; conscious and oriented - drowsy but res%onding to verbalcommand

    '.A) so#t)

    non-tender) non-distended C:3- 3,; 39 normal "o murmur

    +' 5 ,9>.2> mmg ') 5 2>.min )) 5 9>.min !em% 5 128

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    D#"-0

    &.@- calm; conscious and oriented '.A) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur )4

    ) !ab !orsemide 9>mg +D

    +' 5 ,,>.0> mmg ') 5 0

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    D#"-1

    &.@- calm; conscious and oriented '.A) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur )4

    ) !ab Cyra-D &D) In$ Insulin 2hrly) &mit In$ 'antodac

    +' 5 ,,>.0> mmg ') 5 2/.min )) 5 9>.min !em% 5 12H( (+3 5 ,27mg.dl

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    D#"-2

    &.@- calm; conscious and oriented '.A) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur C.&

    ) $oint %ain) "o stool %ass due to lack o# diet

    +' 5 ,/>.2> mmg ') 5 29.min )) 5 7>.min !em% 5 128

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    D#"-3 &.@- calm; conscious and oriented '.A

    ) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur 3M'!&MA!ICALL +@!!@)

    +' 5 ,7>.2>

    mmg ') 5 2>.min )) 5 9>.min !em% 5 12H(

    (+3 5 9

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    D#"-4 &.@- calm; conscious and oriented '.A

    ) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur )4

    ) 3y% A%tivate 9ts# !D3

    +' 5 ,/>.0> mmg ') 5 2>.min )) 5 9>.min !em% 5 12H( (+3 5 7

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    D#"-5 &.@- calm; conscious and oriented '.A

    ) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur C.&

    ) Decreased a%%etite) (ever last night

    )4) !ab 'CM mg 3!A!

    +' 5 ,,>.2> mmg ') 5 02.min )) 5 92.min !em% 5 11H( (+3 5 9

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    D#"-6 &.@- calm; conscious and oriented '.A

    ) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur C.&

    ) Consti%ation since ,> days )4

    ) 3y% 'iclin Jsugar #ree7ts# 3!A! 3

    +' 5 ,7>.2> mmg ') 5 29.min )) 5 99.min !em% 5 128

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    D#"-7 &.@- calm; conscious and oriented '.A

    ) so#t) non-tender) non-distended

    C:3- 3,; 39 normal "o murmur C.&

    ) %ain in legs) )educed sensation

    )4) 'regabalin 0mg 3

    +' 5 ,,>.2> mmg ') 5 02.min )) 5 99.min !em% 5 128

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    Me!iines Presri$e!

    DaysMedicines

    ,.2

    9,.2

    99.2

    97.2

    9/.2

    9.2

    I:("3 9:ac

    3to

    %In$InsulinJ)acc tosliding

    scale

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    Cont!89

    DaysMedicines

    ,

    .2

    9,

    .2

    99

    .2

    97

    .2

    9/

    .2

    9

    .2

    In$@mset2mgI:

    3&3

    !abDolomg3!A!

    !abCyra-D &D

    !ab)ami%ril98mg

    &D

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    SOAP

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    S'$:etie Ei!ene

    Decreased #re6uency o# micturation 'ain in abdomen 'al%itation

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    O$:etie Ei!ene

    @levated Brea Decreased 'otassium Decreased Creatinine @levated +ilirubin

    @levated 3G&! @levated Alkaline 'hos%hatase @levated )andom blood sugar Decreased b @levated @3) @levated !LC B3G 5 e%atomegaly with #atty liver

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    Assess%ent

    'atient admitted with c.o o# decreased #re6uency o# micturation; %ain inabdomen; %al%itation since 7 days

    (rom lab investigation; abnormal levels o# Brea; Creatinine; 'otassium;)andom blood sugar; b; !LC; @3); 3G'!; 3G&!; +ilirubin were#ound8

    (inally the %atient was diagnosed with Chronic Kidney Disorderassociated with diabetes; hy%ertension and anemia8

    'atient was treated with re6uired medications and su%%ortivemedications8 Condition #ound to be im%roving and the %atient #inally gotdischarge8

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    Ph#r%#e'ti#& C#re Pn

    Go#&s o* Ther#(" )elieving %ain in abdomen )elieve %al%itation "ormalize #re6uency o# micturation )elieve consti%ation !reatment o# kidney disorder

    Go#&s Ahiee! 3ym%toms were relieved by thday

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    Pro$&e%s I!enti*ie! Interactions #ound between

    ) )abe%razole and iron )abe%razole decreases the e##ect o# iron byincreasing gastric %8

    ) )ami%ril and !orsemide %codynamic synergism8 )isk o# acutehy%otension ; renal insu##iciency8

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    P#tient Co'nse&&in)

    Adhere to the medication8 @4ercise at least 7> minutes a day8 )educe salt u%take8 3odium u%take should not e4ceed 97>>

    mg %er day8 Increase %otassium rich #ood8 Consume diet rich in #ruits; vegetables and low #at dairy

    %roducts while reducing total and saturated #at intake8

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    !"an4'8ou..9