Clinical and Translational Science Awards (CTSAs): Building Connections

February 4, 2009National Advisory Council on Drug Abuse

Barbara Alving, MD, MACPDirector

National Center for Research Resources

National Center forResearch Resources NATIONAL INSTITUTES OF HEALTH A c c e l e r a t i n g a n d e n h a n c i n g r e s e a r c h f r o m b a s i c d i s c o v e r y t o i m p r o v e d p a t I e n t c a r e

ClinicalClinical

Community

National Center for Research Resources

Accelerating research from basic discovery to improved patient care

Improved patient care Pre-clinical

Animalmodel resources

imaging & informatics advances

Clinicalresearch

support

community engagement

Impetus for the CTSA Program

CTSAWeb.org

Implement biomedical discoveries Develop, test, and bring new prevention

strategies into medical practice more rapidly Catalyze change - lower barriers between

disciplines Encourage creative and innovative

approaches

To ensure new discoveries lead to improved public health, clinical science must evolve to better:

CTSAs – Building a National Consortiumof Academic Health Centers

Members 2006 & 2007

Participating Institutions

WA

OR

CA

NV

AZNM

MT

UT

WY

CO

SD

ND

NE

KS

OK

TXAK

AR

MO

IA

MN

WI

IL IN

MI

OH

KY

TN

MS AL GA

FL

LA

NC

SC

VAWV

PA

NY

VT

NH

ME

MA

DEMD

RI

ID

HI

NJ

PR

New Members 2008

CT

Currently 38 CTSAs Sites Across the Country

CTSA – Providing Local Leveraging Opportunities

Yerkes National PrimateResearch Center

Kaiser PermanenteGeorgia

Atlanta VAMedical Center

Complex Carbohydrate Research Center

at U GeorgiaGeorgia BioGeorgia

Research Alliance

Emory University

Morehouse School of Medicine

CDC

GeorgiaTech

Children’sHealthcareof Atlanta

Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) at Emory University

CTSA – Creating National Partnership Opportunities Consortium Governance

www.ctsaweb.org

Advisory: providing guidance and input to the NCRR Director

Oversight: identifying and selecting collaborative opportunities to facilitate research, coordinating Consortium-wide approaches to research, and overseeing topic-specific efforts across the Consortium

Steering: coordinating institutional topic-specific efforts with the national CTSA Consortium; each Steering Committee has an Operations subgroup that takes timely action on emergent topic issues

CTSA National Strategic Plan Priorities

Goal One: Enhancing National Clinical and Translational Research Capability

Clinical research management Research infrastructure Phenotyping – human and preclinical models

Goal Two: Enhancing Training and Career Development of Clinical and Translational

Investigators

Goal Three: Enhancing Consortium-Wide Collaborations

Social networking Inventory of resources Data sharing

Goal Four: Enhancing the Health of Our Communities and the Nation

Community engagement Public health policy

CTSA – Creating National Partnership Opportunities

Working as a Consortium, we have established a committee structure to execute the vision and goals of the CTSA program

CTSAweb.org

Resources for Researchers

Building Connections

e-Newsletter

Communication Toolkit

CTSA – Creating Regional Partnership Opportunities

= CTSA Institutions

= East Coast Consortium

= Midwest Consortium

= West Coast Consortium

Weill Cornell Medical College

Columbia University

Rockefeller University

Albert Einstein College of Medicine

University of Rochester

Yale University

University of Wisconsin

Mayo Clinic College of Medicine

University of Washington

Oregon Health & Science University

University of California, Davis

University of California,

San Francisco

Stanford University

The Scripps Research Institute

Washington University in St. Louis

Universityof Iowa

University of Chicago

Encouraging and Enhancing Collaboration CTSA Consortium – Informatics Pilots

Implementation and development of tools for clinical investigators to facilitate small and medium sized research studies

Enhance the collection and management of data in small and medium sized studies

Requirements At least three CTSA must collaborate Data and software sharing Must incorporate institutional database support that is flexible, secure, and

easily accessible on demand

Clinical and Translational Information Exchange Environment Informatics Pilots

Informatics Pilot Projects

PhysioMIMI at Case Western Reserve University Includes investigators from Marshfield Clinic, University of Wisconsin and

University of Michigan Collects, manages, and analyzes diverse data types across institutions Allows secure, safe and regulated transfer of information from clinical care

systems and research databases

Sharing Clinical Data at University of Washington Includes investigators from University of California, San Francisco, University

of California, Davis Allow researchers to access large shared datasets Assist with designing research studies and generating hypotheses

Research Electronic Data Capture (REDCap) at Vanderbilt Includes investigators from Oregon Health and Sciences University and Mayo

Clinic Provide an easy way for researchers to develop a secure, web-based

application for collecting, managing and sharing of their clinical and translational research data

Create secure and flexible interoperability between REDCap and external data systems thus ensuring data quality in information exchange

Informatics Pilots

WA

OR

CA

NV

AZNM

MT

UT

WY

CO

SD

ND

NE

KS

OK

TXAK

AR

MO

IA

MNWI

IL IN

MI

OH

KY

TN

MS AL GA

FL

LA

NC

SC

VAWV

PA

NY

VT

NH

ME

MA

DEMD

RI

ID

HI

CT

NJ

PR

University of California, Davis

University of California, San Francisco

Mayo Clinic College of Medicine

University of Washington

Vanderbilt University

Case Western Reserve University

Mansfield Clinic University of Wisconsin–Madison

Oregon Health & Science University

University of Michigan

CTSA Consortium – Building Connections with Business Schools

Develop business plans, design, and implement community

surveys Create innovative cross-educational programs Develop case studies to pilot programs Collaborate with international colleagues Prepare cost analyses Protect CTSA-developed patents Form industry partnership programs

CTSA are partnering with business schools to:

Encouraging and Enhancing Collaboration NIH Opportunities

CTSA Thematic Research Networks/CTSA Interest Groups

Emergency Medicine Sleep Research Network Critical Care Neurology Neuroimaging

Educational Impact of CTSA Program

Doubled the clinical and translational training workforce from 2006 - 2008

Increased the number of regional training interactions among consortium sites

Awarded a supplement to develop a National CTSA Educational Resource Program (NCERP) that will:

Identify, catalog, and assess training modules in clinical and translational research

Enhance and broaden training opportunities for clinician-scientists across the CTSA consortium

Educational Impact of CTSA Program (Based on 2008 Annual Progress Reports from first 24 CTSAs)

Clinical Disciplines (includes 37 subcategories)

Pediatric Disciplines

Public Health

Stats, Res Methods, Informatics

Genetics

Allied Health

Immunology

Nursing

Bioengineering

Neuroscience

Psychology, non-clinical

Physiology

Microbiology and Infect Diseases

Pharmacology

Molecular Biology

Other

Total

3,948

516

317

176

134

121

115

110

108

108

93

77

69

61

53

____250

6,256

272

29

50

10

9

16

7

20

10

18

5

5

8

10

7

_____37

513

Field of Training# of

Investigators# of Trainees and Scholars

CTSA Consortium and NIDA Collaborations(Based on 2008 Annual Progress Reports from first 24 CTSAs)

Columbia University Health Sciences 8

Emory University 1

Johns Hopkins University 19

Oregon Health and Science University 2

Rockefeller University 3

University of California San Francisco 2

University of Chicago 3

University of Pennsylvania 8

NIDA Grants Utilizing CTSAs

CTSA Consortium and NIDA Collaborations(Based on 2008 Annual Progress Reports from first 24 CTSAs)

University of Texas Health Science Center Houston 3

University of Texas SW Medical Center Dallas 3

University of Washington 1

University of Wisconsin Madison 1

Vanderbilt University 3

Washington University 2

Weill Medical College of Cornell University 2

Yale University 29

Total 90

NIDA Grants Utilizing CTSAs

NIDA Clinical Trials Network

Established in 1999 to conduct research

in a wide variety of community based

treatment programs across the United

States. Provides a unique opportunity to

address a variety of underserved

populations, and in particular to evaluate

access to and effectiveness of

treatments for ethnic minorities. Seeks to reduce barriers to all its studies

and has attended carefully to recruitment

and retention of women and ethnic

minority groups.

Clinical Trials Network (CTN)

Opportunities for Partnership with CTSAs and NIDA Clinical Trials Network

WA

OR

CA

NV

AZ NM

MT

UT

WY

CO

SD

ND

NE

KS

OK

TXAK

AR

MO

IA

MN

WI

IL IN

MI

OH

KY

TN

MS AL GA

FL

LA

NC

SC

VAWV

PA

NY

VT

NH

ME

MA

DEMD

RI

ID

HI

CT

NJ

PR

CTN Node

States with CTSAs

Funding Opportunities at NIDA

National Center for Research Resourceswww.ncrr.nih.gov

Translating Research from Basic Discovery to Improved Patient Care