SPECIAL FEATURES

Highlights of This Issue 4627

CCR Translations

4629 Playing the Melanoma EndgameJessica L.F. Teh and Andrew E. AplinSee related article, p. 4771

4631 Immunity War: A Novel Therapy for LymphomaUsing T-cell Bispecific AntibodiesAjay Prakash and Catherine S. DiefenbachSee related article, p. 4785

Review

4633 New Insights from Studies of ClonalHematopoiesisChristopher J. Gibson and David P. Steensma

CLINICAL TRIALS: TARGETED THERAPY

4643 Phase I and Biomarker Study of Plerixafor andBevacizumab in Recurrent High-Grade GliomaEudocia Q. Lee, Dan G. Duda, Alona Muzikansky,Elizabeth R. Gerstner, John G. Kuhn, David A. Reardon,Lakshmi Nayak, Andrew D. Norden, Lisa Doherty,Debra LaFrankie, Jennifer Stefanik, Trupti Vardam,Katrina H. Smith, Christine McCluskey, Sarah Gaffey,Tracy T. Batchelor, Rakesh K. Jain, and Patrick Y. Wen

4650 Phase II Studies with Refametinib or Refametinibplus Sorafenib in Patients with RAS-MutatedHepatocellular CarcinomaHo Yeong Lim, Philippe Merle, Karl Heinz Weiss,Thomas Yau, Paul Ross, Vincenzo Mazzaferro,Jean-Fr�ed�eric Blanc, Yuk TingMa, Chia Jui Yen, Judit Kocsis,Su Pin Choo, Wattana Sukeepaisarnjaroen, Ren�e G�erolami,Jean-Francois Dufour, Edward J. Gane, Baek-Yeol Ryoo,Markus Peck-Radosavljevic, Thong Dao, Winnie Yeo,Wisut Lamlertthon, Satawat Thongsawat, Michael Teufel,Katrin Roth, Diego Reis, Barrett H. Childs, Heiko Krissel,and Josep M. Llovet

4662 Antigen-Specific CD8 Lytic Phenotype Inducedby Sipuleucel-T in Hormone-Sensitive orCastration-Resistant Prostate Cancer andAssociation with Overall SurvivalEmmanuel S. Antonarakis, Eric J. Small, Daniel P. Petrylak,David I. Quinn, Adam S. Kibel, Nancy N. Chang,Erica Dearstyne, Matt Harmon, Dwayne Campogan,Heather Haynes, Tuyen Vu, Nadeem A. Sheikh, andCharles G. Drake

4672 The Role of Adding Somatostatin Analogues toPeptide Receptor Radionuclide Therapy as aCombination and Maintenance TherapyAnna Yordanova, Marcel M. Wicharz, Karin Mayer,Peter Brossart, Maria A. Gonzalez-Carmona,Christian P. Strassburg, Rolf Fimmers, Markus Essler, andHojjat Ahmadzadehfar

CLINICAL TRIALS: IMMUNOTHERAPY

4680 Molecular Analyses Support the Safety andActivity of Retroviral Replicating Vector Toca 511in PatientsDaniel J. Hogan, Jay-Jiguang Zhu, Oscar R. Diago,Dawn Gammon, Ali Haghighi, Guangrong Lu, Asha Das,Harry E. Gruber, Douglas J. Jolly, and Derek Ostertag

PRECISION MEDICINE AND IMAGING

4694 Functional Parameters Derived from MagneticResonance Imaging Reflect Vascular Morphologyin Preclinical Tumors and in Human LiverMetastasesPavitra Kannan, Warren W. Kretzschmar, Helen Winter,Daniel Warren, Russell Bates, Philip D. Allen, Nigar Syed,Benjamin Irving, Bartlomiej W. Papiez, Jakob Kaeppler,Bosjtan Markelc, Paul Kinchesh, Stuart Gilchrist,Sean Smart, Julia A. Schnabel, Tim Maughan,Adrian L. Harris, Ruth J. Muschel, Mike Partridge,Ricky A. Sharma, and Veerle Kersemans

4705 Radiomics Signature on Magnetic ResonanceImaging: Association with Disease-Free Survivalin Patients with Invasive Breast CancerHyunjin Park, Yaeji Lim, Eun Sook Ko, Hwan-ho Cho,Jeong Eon Lee, Boo-Kyung Han, Eun Young Ko,Ji Soo Choi, and Ko Woon Park

October 1, 2018 � Volume 24 � Number 19

Clinical Cancer Research

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4715 Clonal Structures of Regionally SynchronousGastric Adenomas and CarcinomasSeung-Hyun Jung, Shin Young Kim, Chang Hyeok An,Sung Hak Lee, Eun Sun Jung, Hyeon-Chun Park,Min Sung Kim, Yeun-Jun Chung, and Sug Hyung Lee

4726 Comparison of Longitudinal CA125 Algorithmsas a First-Line Screen for Ovarian Cancer in theGeneral PopulationOleg Blyuss, Matthew Burnell, Andy Ryan,Aleksandra Gentry-Maharaj, In�es P. Mari~no,Jatinderpal Kalsi, Ranjit Manchanda, John F. Timms,Mahesh Parmar, Steven J. Skates, Ian Jacobs,Alexey Zaikin, and Usha Menon

4734 Identification of a Genomic Region betweenSLC29A1 and HSP90AB1 Associated with Risk ofBevacizumab-Induced Hypertension: CALGB80405 (Alliance)Megan Li, Flora Mulkey, Chen Jiang, Bert H. O'Neil,Bryan P. Schneider, Fei Shen, Paula N. Friedman,Yukihide Momozawa, Michiaki Kubo,Donna Niedzwiecki, Howard S. Hochster,Heinz-Josef Lenz, James N. Atkins, Hope S. Rugo,Susan Halabi, William Kevin Kelly, Howard L. McLeod,Federico Innocenti, Mark J. Ratain, Alan P. Venook,Kouros Owzar, and Deanna L. Kroetz

4745 Prognostic Value of Methylator Phenotype inStage III Colon Cancer Treated with Oxaliplatin-based Adjuvant ChemotherapyClaire Gallois, Julien Taieb, Delphine Le Corre,Karine Le Malicot, Josep Tabernero, Claire Mulot,Jean-Francois Seitz, Thomas Aparicio, Gunnar Folprecht,Côme Lepage, Enrico Mini, Jean-Luc Van Laethem,Jean-Francois Emile, and Pierre Laurent-Puig for thePETACC8 investigators

4754 Integrating Radiosensitivity and Immune GeneSignatures for Predicting Benefit of Radiotherapyin Breast CancerYi Cui, Bailiang Li, Erqi L. Pollom, Kathleen C. Horst, andRuijiang Li

4763 The Spatiotemporal Evolution of Lymph NodeSpread in Early Breast CancerPeter Barry, Alexandra Vatsiou, Inmaculada Spiteri,Daniel Nichol, George D. Cresswell, Ahmet Acar,Nicholas Trahearn, Sarah Hrebien, Isaac Garcia-Murillas,Kate Chkhaidze, Luca Ermini, Ian Said Huntingford,Hannah Cottom, Lila Zabaglo, Konrad Koelble,Saira Khalique, Jennifer E. Rusby, Francesca Muscara,Mitch Dowsett, Carlo C. Maley, Rachael Natrajan,Yinyin Yuan, Gaia Schiavon, Nicholas Turner, andAndrea Sottoriva

TRANSLATIONAL CANCER MECHANISMSAND THERAPY

4771 Induction of Telomere Dysfunction ProlongsDisease Control of Therapy-Resistant MelanomaGao Zhang, Lawrence W. Wu, Ilgen Mender,Michal Barzily-Rokni, Marc R. Hammond, Omotayo Ope,Chaoran Cheng, Themistoklis Vasilopoulos,Sergio Randell, Norah Sadek, Aurelie Beroard, Min Xiao,Tian Tian, Jiufeng Tan, Umar Saeed, Eric Sugarman,Clemens Krepler, Patricia Brafford, Katrin Sproesser,Sengottuvelan Murugan, Rajasekharan Somasundaram,Bradley Garman, Bradley Wubbenhorst, Jonathan Woo,Xiangfan Yin, Qin Liu, Dennie T. Frederick, BenchunMiao,Wei Xu, Giorgos C. Karakousis, Xiaowei Xu,Lynn M. Schuchter, Tara C. Mitchell, Lawrence N. Kwong,Ravi K. Amaravadi, Yiling Lu, Genevieve M. Boland,Zhi Wei, Katherine Nathanson, Utz Herbig,Gordon B. Mills, Keith T. Flaherty, Meenhard Herlyn, andJerry W. ShaySee related commentary, p. 4629

4785 CD20-TCB with Obinutuzumab Pretreatment asNext-Generation Treatment of HematologicMalignanciesMarina Bacac, Sara Colombetti, Sylvia Herter,Johannes Sam, Mario Perro, Stanford Chen,Roberta Bianchi, Marine Richard, Anne Schoenle,Valeria Nicolini, Sarah Diggelmann, Florian Limani,Ramona Schlenker, Tamara H€usser, Wolfgang Richter,Katharine Bray-French, Heather Hinton,Anna Maria Giusti, Anne Freimoser-Grundschober,Laurent Lariviere, Christiane Neumann, Christian Klein,and Pablo Uma~naSee related commentary, p. 4631

4798 Parallel Accumulation of Tumor Hyaluronan,Collagen, and Other Drivers of TumorProgressionXiaoming Li, H. Michael Shepard, Jessica A. Cowell,Chunmei Zhao, Ryan J. Osgood, Sanna Rosengren,Barbara Blouw, Sheryl A. Garrovillo, Mark D. Pagel,Clifford J. Whatcott, Haiyong Han, Daniel D. Von Hoff,Darin M. Taverna, Michael J. LaBarre, Daniel C. Maneval,and Curtis B. Thompson

4808 LncRNA–FEZF1-AS1 Promotes TumorProliferation and Metastasis in Colorectal Cancerby Regulating PKM2 SignalingZehua Bian, Jiwei Zhang, Min Li, Yuyang Feng, Xue Wang,Jia Zhang, Surui Yao, Guoying Jin, Jun Du, Weifeng Han,Yuan Yin, Shenglin Huang, Bojian Fei, Jian Zou, andZhaohui Huang

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4820 Cancer-Associated Fibroblasts AffectIntratumoral CD8þ and FoxP3þ T Cells Via IL6 inthe Tumor MicroenvironmentTakuya Kato, Kazuhiro Noma, Toshiaki Ohara,Hajime Kashima, Yuki Katsura, Hiroaki Sato,Satoshi Komoto, Ryoichi Katsube, Takayuki Ninomiya,Hiroshi Tazawa, Yasuhiro Shirakawa, andToshiyoshi Fujiwara

4834 Clinical Relevance and Suppressive Capacity ofHuman Myeloid-Derived Suppressor CellSubsetsStephan Lang, Kirsten Bruderek, Cordelia Kaspar,Benedikt H€oing, Oliver Kanaan, Nina Dominas,Timon Hussain, Freya Droege, Christian Eyth,Boris Hadaschik, and Sven Brandau

4845 Inhibition of BET Bromodomain Proteins withGS-5829 and GS-626510 in Uterine SerousCarcinoma, a Biologically Aggressive Variant ofEndometrial CancerElena Bonazzoli, Federica Predolini, Emiliano Cocco,Stefania Bellone, Gary Altwerger, Gulden Menderes,Luca Zammataro, Anna Bianchi, Francesca Pettinella,Francesco Riccio, Chanhee Han, Ghanshyam Yadav,Salvatore Lopez, Aranzazu Manzano, Paola Manara,Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi,Elena Ratner, Dan-Arin Silasi, Gloria S. Huang,Masoud Azodi, Peter E. Schwartz, Joseph Schlessinger,and Alessandro D. Santin

4854 Assessing Therapeutic Efficacy of MEK Inhibitionin a KRASG12C-Driven Mouse Model of LungCancerShuai Li, Shengwu Liu, Jiehui Deng, Esra A. Akbay,Josephine Hai, Chiara Ambrogio, Long Zhang,Fangyu Zhou, Russell W. Jenkins, Dennis O. Adeegbe,Peng Gao, Xiaoen Wang, Cloud P. Paweletz,Grit S. Herter-Sprie, Ting Chen, Laura Guti�errez-Quiceno,Yanxi Zhang, Ashley A. Merlino, Max M. Quinn, Yu Zeng,Xiaoting Yu, Yuting Liu, Lichao Fan, Andrew J. Aguirre,David A. Barbie, Xianghua Yi, and Kwok-Kin Wong

4865 Multimodality Treatment of Desmoplastic SmallRound Cell Tumor: Chemotherapy andComplete Cytoreductive Surgery ImprovePatient SurvivalVivek Subbiah, Salah-Eddine Lamhamedi-Cherradi,Branko Cuglievan, Brian A. Menegaz, Pamela Camacho,Winston Huh, Vandhana Ramamoorthy,Pete M. Anderson, Raphael E. Pollock, Dina C. Lev,Wei Qiao, Mary Frances McAleer, Robert S. Benjamin,Shreyaskumar Patel, Cynthia E. Herzog, Najat C. Daw,Barry W. Feig, Alexander J. Lazar, Andrea Hayes-Jordan,and Joseph A. Ludwig

4874 Dual Src and MEK Inhibition Decreases OvarianCancer Growth and Targets Tumor InitiatingStem-Like CellsFiona Simpkins, Kibeom Jang, Hyunho Yoon,Karina E. Hew, Minsoon Kim, Diana J. Azzam, Jun Sun,Dekuang Zhao, Tan A. Ince, Wenbin Liu, Wei Guo,Zhi Wei, Gao Zhang, Gordon B. Mills, andJoyce M. Slingerland

4887 Comprehensive Profiling of DNA Repair Defectsin Breast Cancer Identifies a Novel Class ofEndocrine Therapy Resistance DriversMeenakshi Anurag, Nindo Punturi, Jeremy Hoog,Matthew N. Bainbridge, Matthew J. Ellis, andSvasti Haricharan

4900 Chemotherapy Sensitizes Therapy-ResistantCells to Mild Hyperthermia by Suppressing HeatShock Protein 27 Expression in Triple-NegativeBreast CancerChaofeng Mu, Xiaoyan Wu, Xinyu Zhou, Joy Wolfram,Jianliang Shen, Dechen Zhang, Junhua Mai, Xiaojun Xia,Ashley M. Holder, Mauro Ferrari, Xuewu Liu, andHaifa Shen

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ABOUT THE COVER

The cover shows a section of a murine squamous cell carcinoma (KLN205). Immunologicalstaining highlights hypoxic regions (green), blood vessels (red) and doxorubicin drugpenetration (blue). For details, see the article by Li and colleagues on page 4734 of this issue.

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