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Clinical Drug Investigation
Prevalence of desloratadine slow metabolizer phenotype and
food-dependent pharmacokinetics of desloratadine in
healthy Chinese volunteers
Ting Wang1, Kun Zhang1, Tingting Li2, Lin He3, Huiru Xie1, Xuehua
Jiang1 and Ling Wang1
Corresponding author:
Ling Wang. E-mail: [email protected]
1 Department of Clinical Pharmacy and Pharmacy Administration, Key
Laboratory of Drug Ministry of Education, West China School of
Pharmacy, Sichuan University, China,
2 Pharmacy Department of People's Hospital of Xishuangbanna Dai
Autonomous Prefecture, China,
3 Department of Pharmacy, Sichuan Provincial People’s Hospital,
China
Electronic Supplementary Material
Supplemental Figure Legends
Fig. S1. Chemical structures with fragmentation and product ion spectrum of [M + H]+ of desloratadine
(a), 3-OH-desloratadine (b) and diphenhydramine (c) (IS).
Fig. S2. MRM chromatogram of blank plasma (a); blank plasma spiked with desloratadine and
3-OH-desloratadine with their IS (10 ng/mL) at the LLOQ (0.05 ng/mL) (b); a plasma sample obtained
from a subject at 1.5 h post dosing (c).
Fig. S3. Individual pharmacokinetic parameters for desloratadine (a, b) and 3-OH-desloratadine (c, d)
following oral administration of 5 mg desloratadine tablet.