Clinical Improvement in Cancer Patien ts through

25Journal of International Society of Life Information Science (ISLIS) J. Intl. Soc. Life Info. Sci. Vol.33, No.1, March 2015

Clinical Improvement in Cancer Patients through Integrated Medicine, Mainly Using Low Molecular Weight Fucoidan Supplements

Shinji NISHIMOTO

Nishimoto Clinic (Wakayama, Japan)

(Received on November 11th, 2014; Final Revised and Accepted on January 15th, 2015)

Abstract: There has been a gradual increase in recent years in the number of progress reports on the use of integrated medicine for cancer treatment over long periods of time. This paper reports on the further progress of 5 cases that I had reported in 2004 at the ISLIS meeting held in South Korea. Also included are new case reports of a 73-year-old male patient with prostate cancer, a 79-year-old male with liver cancer, a 76-year-old female with metastatic pancreatic cancer after resection of gastric cancer and a 55-year-old female with Stage IV A thyroid cancer all of whom received alternative therapy for at least 5 years. Additionally the case is described for a 58-year-old female with Stage IIA breast cancer whose anti-p53 antibody level, an indicator of apoptosis, showed a significant decrease in less than 5 years of alternative therapy. Although 4 of these 10 patients have died, their cases are reported here so that others can learn from the course of their disease progression. Finally, the current practices adopted in Nishimoto Clinic are reported; these have been applied in an integrated medicine approach to cancer treatment for more than 10 years. Key words: Alternative medicine, low molecular weight fucoidan, breast cancer, uterine cancer, kidney cancer, liver cancer, metastatic lung cancer, prostate cancer, thyroid cancer, metastatic pancreatic cancer, apoptosis, stellate ganglion block (SGB), stellate ganglion near-infrared light irradiation (SGL)

1. Introduction

In my long experience of using an integrated medicine approach for cancer treatment, I have been studying and clinically applying qigong (internal and external), laughter therapy, autogenic training, imagery therapy, Chinese herbal medicine, supplements, water therapy, and diet therapy to improve immunity. About 20 years ago, I had the good fortune to come into contact with Professor Shirahata of the Faculty of Agriculture of Kyushu University, a leading researcher on active hydrogen, and I have been doing joint research with him. He told me about low molecular weight fucoidan about 11 years ago. After that, I added fucoidan to the clinical treatment being used at Nishimoto Clinic, although only in a few cases, and cases that showed good progress were reported at the 2004 ISLIS meeting held in South Korea14). Integrated medicine has been drawing greater attention in Japan particularly since the earthquake and tsunami of March 11, 2011. Outpatient treatment with integrated medicine has now been adopted by some

private university hospitals and its efficacy is gradually being recognized. In particular, it is envisaged that the importance of treatments tailored to the conditions of individual patients, as is employed in Chinese herbal medicine, will increase. In the Japanese medical community also, the holistic approach, i.e., medical care that takes the body, mind and spirit into account, is gradually gaining acceptance. In the field of pain management, an understanding of spiritual pain by the care giver is considered necessary especially at the terminal stage. Twenty-four years ago, in the second year after becoming an anesthesiologist I was diagnosed with pan-ulcerative colitis and was told that I was 7 to 10 times more likely than my contemporaries to develop colon cancer 10 years later. Since then, I have tried to clinically apply various alternatives to western medicine, to patients including myself. Among such alternative therapies, I have published a few papers on qigong some of which have been presented in meetings that dealt with pain management1-4). I have also reported cases6) of elimination of tumors (mucocele and ovarian) that were achieved by exploiting the physiological response of the body to energy-irradiated water5); this was an alternative therapy that was effective on myself. The relationship between the autonomic nerves and

___________________________________________________ Shinji Nishimoto Nishimoto Clinic, 2F Waichi Building, 16-banchi, 7-bancho, Wakayama-shi, 640-8156 Japan Tel: 073-428-1220 Fax: 073-428-0949 E-mail: [email protected]

Case Study

International Society of Life Information Science(ISLIS)

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26 Journal of International Society of Life Information Science (ISLIS) J. Intl. Soc. Life Info. Sci. Vol.33, No.1, March 2015

immunity is better understood now on the basis of the Fukuda-Abo theory7) and it has been clarified that a stress-induced state of sympathetic hyperactivity was at the root of the pathophysiology of both ulcerative colitis and cancer. Various types of advice can be given from the viewpoint of preventive medicine by measuring the actual count and percentage of lymphocytes, as has been demonstrated by clinicians for many years. Nishimoto Clinic uses devices that can test the ability of treatments to regulate the autonomic nervous system and the balance between sympathetic and parasympathetic nerves using the R-R interval in electrocardiograms as an index and it uses other devices that can measure the degree of arteriosclerosis. Changes in the measured values of these parameters before and after the use of supplements, etc. are measured and used as indices for evaluating the effectiveness of the treatments. At the clinic, the balance of the actions of supplements is taken into account, such as: (1) an immunopotentiating effect, (2) an inhibitory effect on active oxygen formation, (3) an inhibitory effect on tumor neovascularization, (4) an enhancement of micronutrient (vitamins, minerals, enzymes, etc) absorption, and (5) a promotion of the excretion of harmful chemical substances from the body, with advice to the patient not to use more than one supplement with a similar effect. The effectiveness of low fat diets8, 9) and soya bean supplements10) against breast cancer and prostate cancer has been scientifically evaluated and reported. During the period since the 2004 ISLIS meeting, I have added various therapies, including stellate ganglion block and near-infrared irradiation around the stellate ganglion, to the integrated medicine regime consisting mainly of low molecular weight fucoidan supplement therapy. The present paper gives interim clinical reports of a few cases where the immune system and tumor marker levels have improved, or the tumors themselves have disappeared12). As evidence based medicine (EBM), my studies are not even at the level of randomized comparative trials (RCTs). However, they are reported here with the hope that they may be useful in some way to people with intractable diseases, in the changing scenario of future medical care.

2. Methods

(1) Fucoidan, derived from mozuku (Nemacystis

decipiens) produced in Tonga, the molecular weight of which was reduced to not more than 500 from the initial 200,000 to 800,000 using a special enzyme, was used on 10 patients diagnosed with different cancers. (The dosage was decided on the basis of body weight and cancer stage as described for each

case.) (2) Structural analysis of the fucoidan showed that its

sugar component was 73% fucose, 12% xylose, 7% mannose and 4% glucose. The fucose was mainly L-fucose and it had a high content of sulfate groups (14.5%), a characteristic feature.

(3) Within the integrated medicine program that was used at the clinic, a treatment strategy was adopted that took into account the patient’s own wishes and my assessment. The therapy was then decided after obtaining consent from the patient and family members.

(4) Near-infrared irradiation and 5-6 mL of 1% mepivacaine were used as western medicine techniques working on the stellate ganglion. A method expected to improve the blood flow into the hypothalamus and cause sympathetic nervous system block was used.

(5) Chinese herbal medicines were prescribed according to the disease. As for qigong, Lin Housheng’s Taiji qigong of 18 forms, famous for its anesthetic effect, was used for internal qigong and Nakagawa’s Shinkiko was used for external qigong.

(6) Simonton therapy was used for imagery therapy and Shultz-style autogenic training for self-hypnosis.

(7) Breath work, music therapy and laughter therapy were all guided throughout by me, as has been done from the time when the clinic was opened.

(8) Changes in tumor markers, tumor immunity, PET, lymphocyte count and percentage, and other parameters of the 10 cases which could be used as indices of therapeutic efficacy are reported here.

3. Case reports

[Case 1] 48-year-old female <Diagnosis> Bilateral breast cancer, metastasized to bone and lung <Chief complaint> Pain in the right shoulder and back <Past medical history> Nothing special <Family disease history> Grandfather had lung disease, father had emphysema <History of present illness> The patient came to the clinic for a checkup in March 2003, with pain in the right shoulder. Blood tests were carried out as she also had back pain and a lump in her right breast. As the test results showed high levels of CA15-3 and CA125 markers, she was referred to the department of surgery of a general hospital. Palpation found suspected cancer in the right breast, swelling of the right axillary lymph nodes and suspected cancer in the left breast. Biopsy led to diagnosis of Stage II breast cancer. Bilateral mastectomy, anticancer chemotherapy and radiotherapy were recommended. She sought a second opinion from another surgeon and underwent tests like




CT, bone scintigraphy (Fig. 1), etc. in another hospital which revealed metastatic cancer in the right scapula, thoracic vertebra and the upper part of the right lung. Finally, Stage IV breast cancer was diagnosed. I discussed the case with the patient and her family members and sought the opinion of some surgeons who also advocate holistic treatment. After that, it was decided to formulate a treatment strategy focused on alternative medicine. Immuno Dock (comprehensive immunological screening for cancer) tests were conducted on April 9, 2003 to investigate tumor immunity.

Fig. 1 Case 1, bone scintigraphy images

<Treatment> Alternative therapy with supplements, mainly low molecular weight fucoidan (200 mL/day), breath work, qigong (external and internal), mental healing, loquat moxa and music therapy were used. <Test results> Immuno Dock test results are given in Fig. 2. PET results are given in Fig. 3. Changes in CA15-3 and CA125 levels are shown in Fig. 4. CT scans of axillary lymph nodes and lungs are reproduced in Fig. 5. Chest x-rays are given in Fig. 6.

Fig. 2 Immuno Dock test data

Fig 3 Results of PET carried out in November 2003

Fig. 4 Changes in CA15-3 and CA125 levels during 2005

Fig 5 CT scans of axillary lymph nodes and

lungs done in March 2005

Fig. 6 Chest X-rays

(a) October 7, 2005 (b) October 28, 2005

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<Additional information on progress> The patient continued to work in a clinic until the autumn of 2005 as she had desired, but she had to be admitted as an emergency case in a nearby hospital because of dyspnea (++). Her pleural ascites was treated and after about one month of hospitalization, she gave a very frank presentation about her medical condition in a general meeting of the Ikigai (Reason for Living) medical network research group of doctors, dentists and nurses. She continued receiving medical treatment at home but had to be hospitalized again and died peacefully at the age of 48 on February 24, 2006, the 3rd day of the hospitalization. No narcotics and no pain medications were required during this treatment. [Case 2] 60-year-old female <Diagnosis> Uterine cervical cancer, breast cancer <Chief complaint> Sense of discomfort in breast, tumor mass <Past medical history> Nothing special <Family disease history> Nothing special <History of present illness> She had undergone surgery on August 1, 2002, and received 28 courses of chemotherapy after that. In April 2003, she was diagnosed to have Stage I breast cancer and had a 1cm lump in her right breast for which surgery was recommended. She then visited Nishimoto Clinic to explore the feasibility of alternative medicine treatment. <Treatment> Alternative therapy with supplements, mainly low molecular weight fucoidan (200 mL/day), breath work, qigong (external and internal) and mental healing were used. <Test results> Changes in WBC and lymphocyte counts and CA15-3 and CA125 levels are given in Fig. 7.

Fig. 7 Changes in WBC and lymphocyte counts

and CA15-3 and CA125 levels. <Effects of treatment> The physical condition was good. The 1 cm tumor in the right breast disappeared by October 2003. <Additional information on progress> Her condition has remained good to the time of writing (January 2015).

[Case 3] 35-year-old female <Diagnosis> Uterine cervical cancer, HPV infection <Chief complaint> Pain in the lower abdomen, irregular genital bleeding <Past medical history> Constipation <Family disease history> Paternal grandfather had lung cancer, father had stomach cancer, a maternal uncle had stomach cancer, and mother had breast cancer. <History of present illness> She had pain in the lower abdomen since November 2002 and the examination in the gynecology department of a general hospital had revealed some abnormality. Cytology done twice, on November 29 and December 4, 2002 revealed the presence of atypical cells indicative of Stage IIIa cervical cancer. Surgery was recommended as she was positive for HPV. But both the patient and her family members wanted to avoid surgery and came to the clinic seeking the possibility of treatment with oriental medicine. She was treated with Chinese herbal medicine, qigong and supplements under the condition that she would undergo regular checkups in a department of gynecology of a hospital that had facilities for cervical conization if it became necessary. Although the lower abdominal pain was mitigated, histological examination showed that the cancer was progressing from Stage V to early stage cancer and cervical conization was recommended by the gynecologist. The case was discussed with her family members at that time and from May 2003, treatment with supplements, mainly low molecular weight fucoidan, was started. Histological examination after a few months showed no atypical cells and the condition became Stage IIa; the gynecologist advised her that there was no need for conization for the time being. <Treatment> Imagery therapy, self-hypnosis, qigong (internal), and alternative therapy with supplements mainly low molecular weight fucoidan (200 mL/day) were given. <Additional information on progress> Her physical condition has continued to be good to the time of writing (January 2015). She married in 2006 and is now the mother of 3 children. [Case 4] 84-year-old male <Diagnosis> Kidney cancer <Past medical history> Lumbar intervertebral disc herniation (at age 27) <Family disease history> Nothing special <History of present illness> After being diagnosed with cancer in the right kidney in June 2000, he underwent extirpative surgery in a general hospital. However, he started to have hematuria again in June 2003. CT done in the general hospital showed that he had a 15 mm tumor in his left kidney. As he wanted to avoid surgery because

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of his advanced age, he came to Nishimoto Clinic. His condition remained good for about 3 months after his first visit during which time he received treatment with oriental medicine. However, he developed 2+ hematuria in October 2003. I therefore added fucoidan to his treatment which improved his lower back pain, hematuria, etc. The tumor remained the same size (15mm) in the CT scan but his quality of life (QOL) continued to be good and progress had been smooth. <Treatment> Alternative therapy with supplements, mainly low molecular weight fucoidan (60 mL × 3, 180 mL/day), was given. This improved the lower back pain, hematuria and anxiety, and also increased his will to live. <Additional information on progress> After TUR-Bt, the urologist suggested surgery even though the tumor was benign, and he underwent nephrocystectomy. Dialysis was started and the prostate was also resected. He died of cerebral infarction at the age of 84, on May 16, 2006, one year after the start of dialysis. [Case 5] 82-year-old female <Diagnosis> Hepatitis C, cirrhosis of the liver, liver cancer <Chief complaint> General fatigue <Past medical history> She had pneumonia 13 years ago and was diagnosed at that time to have hepatitis C also. She received interferon treatment 10 years ago which reduced the virus level to (–) (she had the side effects of reduced platelet and WBC counts, and febrile pneumonia (+)). <Family disease history> Younger sister had Parkinson’s disease. <History of present illness> She felt general fatigue beginning in April 2003 and got tested at a nearby internal medicine clinic where she was undergoing treatment for hepatitis C and liver cirrhosis. There was a sharp increase in AFP, which was 166.6 ng/mg on April 2 and became 605.3 ng/mg on May 8, 2003. As liver cancer was suspected, she had a CT scan in a nearby general hospital which detected a 2 cm cancerous tumor at the boundary between the left and right hepatic lobes. Hospitalization was recommended. However, she preferred treatment with oriental medicine and visited Nishimoto Clinic. Various possible treatments including radio wave therapy were discussed with the patient, because of her low platelet count of less than 50,000, advanced age, and strong preference for alternative medicine, however, alternative therapy, mainly the administration of fucoidan was chosen. <Treatment> Alternative therapy with supplements, mainly fucoidan (200 mL/day for 3 months and then 100 mL/day), qigong (both internal and external), self hypnosis, and imagery therapy were used. <Effects of treatment> There was mitigation of general

fatigue and an increase in appetite. The patient was diagnosed to be normal after a CT scan on December 22, 2003. A CT scan done in June 2004 also found no abnormality. <Test results> Changes in WBC and AFP and in HbA1c are shown in Figs. 8 and 9, respectively.

Fig. 8 Changes in WBC and AFP

Fig. 9 Changes in HbA1c

<Additional information on progress> The patient came to realize through contracting the disease of liver cancer that “human beings are protected by various natural rules that are not easy to perceive”. This is what she said at a seminar held in August 2007. The patient was admitted to a general hospital in December 2013 with an infection. Her condition improved with the use of antibiotics. But after shifting her to home medical care she died on February 5, 2014 at the age of 82. [Case 6] 79-year-old male <Diagnosis> Liver cancer, metastasized lung K, migraine <Past medical history> He had pulmonary tuberculosis, acute appendicitis and surgery for removal of right ureteral calculus in his 20’s, and hepatitis C in his 40’s. <History of the present illness> A small tumor was detected in the liver in 2007 but it was just kept under observation. Hepatocellular carcinoma was detected at two locations in December 2009. Transcatheter arterial

Changes in WBC and AFP (WBC) (AFP)

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embolization was done in June 2010. Hepatectomy (S2 and S3) was done in July of the same year. In June 2011, the cancer relapsed. Radio frequency ablation and ethanol embolotherapy were administered. The cancer metastasized to the lymph nodes near the liver in September 2011. A total of 25 radiotherapy sessions were given (5 times a week × 5 weeks) starting at the end of October, but the cancer showed a tendency to expand and metastatic lung cancer was also detected. Although surgery and systemic administration of anticancer agents were strongly recommended, the patient wanted some other treatment and came to the clinic. When he came here on May 7, 2012 seeking a second opinion, he had brought with him some laboratory test results that showed AFP of 25,036 and PIVKA-II of 4,260 measured on April 6, 2012 at Hospital H, and AFP of 61,978 and PIVKA-II of 5,880 measured on April 24, 2012 at a center for adult diseases. He was under severe psychological stress because of the sharp increase in AFP and at the verge of collapse physically also. <Treatment> An integrated medicine approach as taken. It included stellate ganglion block (SGB) once or twice a month, stellate ganglion near-infrared light irradiation (SGL) once or twice a month, negative ion therapy, 200-300 mL/day of low molecular weight fucoidan, autogenic training, breath work, nail rubdown, arm swinging exercise, Taiji qigong of 18 forms, Chinese herbal medicine (Hochuekkito), and external qigong. <Test results> Changes in AFP and other quantities are shown in Fig. 10. The changes in WBC and related data are shown in Fig. 11. CT images are reproduced in Fig. 12.

Fig. 10 Changes in AFP and other quantities

Fig. 11 Change in WBC and related data

Fig. 12 CT images

<Report on recent progress> In December 2009, about 5 years after the diagnosis of hepatocellular carcinoma was confirmed and two and a half years after his first visit to the clinic, tumors were still seen in the CT scan and AFP was high at 7,000-9,000. However, his QOL remains good and the albumin level and platelet count have been showing upward trends from October 2014. [Case 7] 55-year-old female <Diagnosis> Stage IVA thyroid cancer metastasized to lymph nodes in the neck <Past medical history> Nothing special <Family disease history> Nothing special <History of present illness> On December 28, 2007, the patient noticed a tumor in her neck, consulted a neighborhood physician and had a checkup in a general hospital. Cytological examination of the thyroid gland led to diagnosis of a malignant tumor. Subsequently PET confirmed metastasis of the cancer to lymph nodes in the neck. Although surgery was recommended, she came to Nishimoto Clinic to explore the possibility of treatment without surgery and to obtain a second opinion. <Treatment> An integrated medicine approach was taken. It included stellate ganglion near-infrared light

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irradiation (SGL) once a month, negative ion therapy, 200-300 mL/day of low molecular weight fucoidan, autogenic training, breath work, nail rubdown and arm swinging exercise. <Test results> Change in anti-p53 is shown in Fig. 13 and the changes in WBC and related data are shown in Fig. 14.

Fig. 13 Change in anti-p53 from February 2008 to

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Fig. 14 Changes in WBC and related data

<Additional information on progress> Although surgery was recommended, administration of 200-300 mL/day of the low molecular weight fucoidan resulted in a decreasing trend of the anti-p53 antibody level and the patient was kept under observation. She was showing signs of (++) level of apoptosis and gradually things were moving towards normalcy. She continued to show improvement. After the parameters reached normal levels, the dose of low molecular weight fucoidan was reduced to 60 mL/day. For the past one year she has been under observation while receiving physiotherapy only. [Case 8] 76-year-old female <Diagnosis> Metastatic pancreatic cancer

<Past medical history> Gastric cancer resected at age 69, cirrhosis of the liver <Family disease history> Daughter has RA <History of present illness> In September 2012 she was diagnosed with metastatic pancreatic cancer in a general hospital and was told that she had only 6 months to live if no anti-cancer drugs were used. Opting to receive integrated therapy, she came to the clinic the next month. Low molecular weight fucoidan treatment was started from January 2013 as markers were showing an increasing trend. <Treatment> An integrated medicine approach was taken. It included stellate ganglion near-infrared light irradiation (SGL) once or twice a month, negative ion therapy, Chinese herbal medicine (Hochuekkito), autogenic training, 200-300 mL/day of low molecular weight fucoidan, breath work, nail rubdown, arm swinging exercise, Taiji qigong of 18 forms, external qigong, music therapy and laughter therapy. <Test results> Changes in CEA and AFP are shown in Fig. 15 and the changes in albumin and platelet count are shown in Fig. 16. Changes in WBC and related data are shown in Fig. 17.

Fig. 15 Changes in CEA and AFP from October

2012 to May 2014

Fig. 16 Changes in albumin and platelet count

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<Additional information on progress> Five to six times a month, the patient attended a wellness class held twice weekly at the Kishu Oriental Medicine Research Institute (Kishu Toyo Igaku Kenkyusho) She also attended voice healing sessions, seminars held at a hot spring resort and 3-day fasting, as a part of integrated therapy. Her QOL remained good. She participated in Awaodori dancing and seminars at Izumo Grand Shrine and Kumano Hongu Shrine. She was under medical care at home from June 2014 and died there peacefully on July 23, 2014. [Case 9] 73-year-old male <Diagnosis> Prostate cancer <Past medical history> Gall stone surgery at age 59 <Family disease history> Nothing special <History of current illness> In November 2003, at age 62, he had a comprehensive medical checkup which showed the PSA of 4.7. As this suggested the possibility of prostate cancer he had to decide whether to go in for a detailed examination or go for a retest 6 months later, and he chose the latter. He decided on his own to take 50 mL/day of bracket fungus extract for 6 months and watch the progress. In the retesting in May 2004, the PSA was found to have increased to 5.4. In July of the same year he was hospitalized at Cancer Center A and underwent pathology tests which showed moderately differentiated adenocarcinoma. His PSA was then 6.1. Although there was no metastasis, infiltration was detected in CT, MRI, bone scintigraphy and cystoscopy carried out in August 2004, and surgical resection was recommended. As the earliest the operation could be scheduled for was at the end of 2004, the patient chose hormone treatment. In September 2004, after getting a second opinion, the patient opted for pinpoint radiotherapy at K University Hospital. Retesting at the Cancer Center A gave the PSA result of 2.36 following which the hormone therapy was discontinued. In November 2004, he visited Nishimoto

Clinic for a second opinion and to explore the feasibility of integrated therapy with low molecular weight fucoidan. <Treatment> An approach of integrated medicine was taken. It included stellate ganglion near-infrared light irradiation (SGL) once or twice a month, negative ion therapy, autogenic training, 200-300 mL/day of low molecular weight fucoidan (for one year only) followed by 60-100 mL/day (for 2 years) (PSA had increased when a lower priced fucoidan from another source had been used), breath work, nail rubdown, arm swinging exercise and Taiji qigong of 18 forms. <Test results> Change in PSA is shown in Fig. 18. Changes in WBC and related data are shown in Fig. 19.

Fig. 18 Change in PSA from April 2009 to October

2014


<Additional information on progress> Although diagnosed with prostate cancer in 2004 through pathology tests, treatment with low molecular weight fucoidan and integrated medicine at the clinic allowed him to maintain good QOL for nearly 10 years. The PSA level increased at times during this period, but the patient remained under observation and his lymphocyte count



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and lymphocyte percentage were checked once every 3-4 months or so according to the Fukuda-Abo theory. His mental state has been stable. [Case 10] 58-year-old female <Diagnosis> Breast cancer <Past medical history> Nothing special <Family disease history> Nothing special <History of the present illness> She noticed a lump in her left breast in May 2012 and immediately visited a nearby doctor. Biopsy revealed cancer in the left breast. Mastectomy of the left breast was done on June 5. Sentinel node biopsy done on the same day was negative. Pathology tests showed that it was Stage IIA HER2 (3+) papillotubular carcinoma with negative margin. On June 14, after the first round of chemotherapy (TC therapy), she felt strong systemic fatigue (+) and chemotherapy was halted. She came to Nishimoto Clinic for a second opinion. <Treatment> A western medicine approach was adopted. The treatment included stellate ganglion block (SGB) once or twice a month, stellate ganglion near-infrared light irradiation (SGL) once or twice a month, negative ion therapy and 200-300 mL/day of low molecular weight fucoidan. An autogenic training oriental medicine approach, breath work, nail rubdown, imagery therapy, laughter therapy, A-i-u-be vocal exercise, music therapy, 3-day fasting of integrated medicine and arm swinging exercise and Taiji qigong of 18 forms were included. <Test results> Changes in WBC and related data are shown in Fig. 20. Change in anti-p53 is shown in Fig. 21.

Fig. 20 Changes in WBC and related data from

August 2012 to November 2014

Fig. 21 Change in anti-p53

<Additional information on progress> With the aforesaid therapies given after halting the anticancer drug treatment, the anti-p53 antibody level came down to less than 10 from more than 500. The patient could return to work, her QOL has remained good, and she is under observation at the time of writing (January 2015).

4. Discussion

I was diagnosed with pan-ulcerative colitis 24 years ago. At that time, I was told that I was 10 times more likely than my contemporaries to develop colon cancer within 10 years. Against this backdrop, I have been researching and applying therapies best suited for me. I used qigong (internal and external), energy irradiated water therapy, supplements, anaerobic bacteria that regulate gut microflora, etc., keeping in mind the balance with western medicine. I used western drugs (steroids, Pentasa, etc.) only during the acute phases. It has now been 17 years since my last hospitalization and during this time I could live normally without the help of western medicines and without any relapse. Being a physician myself, the experience of having an intractable disease made a major contribution to my ability to provide support to people afflicted with the difficult disease of cancer. At the same time, it has had a significant bearing on the style of medical care provided by me to patients. I have been clinically applying qigong (internal and external) and breath work techniques that I have chosen and practiced myself at the Kishu Oriental Medicine Research Institute while at the same time not allowing any harmful chemicals including environmental hormones to enter the body through food or items of daily use. In addition to these two basic components, I use Chinese herbal medicine and supplements as needed in my practice of integrated medicine. The low molecular weight fucoidan, the main supplement component used in the present study is a

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polysaccharide present in brown algae such as mozuku, mekabu, konbu (edible kelp), etc. This fucoidan has been reported to have (1) an immunopotentiating effect, (2) an inhibitory effect on tumor neovascularization and (3) an apoptotic action, on cancer cells. There has been a lot of research in western countries on the effect of fucoidan. In Japan, a paper on “Apoptosis of human gastric cancer and colon cancer cell lines, induced by fucoidan from konbu and its enzymatic digestion product”12) was presented at the 55th Meeting of the Japanese Cancer Association. In 2013, Shirahata et al. 13) reported on the induction of apoptosis of breast cancer cells by low molecular weight fucoidan. Shirahata and his group have been studying the apoptotic action of low molecular weight fucoidan of mozuku origin and have reported that it had apoptotic action on the human fibrosarcoma (a type of cancer) cell line HT1080. They also observed apoptosis inducing action proportionate to the fucoidan concentration when they added low molecular weight fucoidan at different concentrations to human leukemia cells HL60. Japan’s National Health Insurance System has approved the use of fucoidan in treating breast cancer, colon cancer and esophageal cancer, which is an acknowledgement of its efficacy in inducing apoptosis in the clinical context. In the present report, examples were presented where the anti-p53 antibody data were improved with the use of fucoidan. As for the immunopotentiating effect, low molecular weight fucoidan has been shown to stimulate the antenna like parts of macrophages. The antenna that recognizes the basic structure of sugars is called toll-like receptor 4 (TLR4). When TLR4 is thus stimulated, the macrophage produces interleukin 12 (IL-12) an anti-tumor cytokine. IL-12 functions to activate immune cells and facilitates the secretion of the protein interferon � which attacks cancer cells. With Case 1, the tumor immunity data on April 9, 2003, before starting the low molecular weight fucoidan treatment, had IL12 of 12.3 and interferon � of14.4. But after starting the treatment, these values rose to 166 and 89.9 on May 23 and 215.5 and 188.1 on August 18, as had been reported at the 2004 ISLIS meeting in South Korea14). As mentioned in the Methods section, the low molecular weight fucoidan used in the present study has a particularly large content of sulfated fucose. Proof of this compound being effective against cancer has been accumulating. Another characteristic of fucoidan used in the present study is that its molecular weight is reduced. This facilitates its smooth absorption into the blood vessels and the consequent expression of its effectiveness against cancers of various organs, unlike the fucoidan types used so far which have shown their effectiveness mainly in the digestive tract.

None of the 5 cases reported earlier were treated with the 3 conventional cancer therapies for various reasons; only alternative therapies were used. The reasons for doing so were as follows. With Case 1, the cancer stage was IV and the patient and her family expressed their preference for alternative therapy during consultations. With Case 2, the patient had experienced a very difficult hospitalization during which she had 28 courses of chemotherapy after cervicectomy. Her lymphocyte count was also low and she strongly wished to try alternative therapies at that time. The Case 3 patient was advised to have a hysterectomy as the treatment of first choice because early stage uterine cancer had been detected and she was HPV positive. But the patient wanted to have a child later and after learning about environmental hormones, etc. she realized that her family was a cancer prone family. Thus, alternative therapy was chosen. Case 4 had the experience of a very bad physical condition during hospitalization after undergoing surgery in 2000 for removal of kidney tumors. Moreover, alternative therapy was preferred as the patient was in his 80s. The Case 5 patient knew about the availability of less invasive therapies for liver cancer, but he had interferon treatment which caused him almost to die. He therefore chose alternative therapy. With all the cases, testing was done according to the procedures of western medicine and if the situation so demanded, the option of going for western medicine treatment in consultation with family members was always kept open. The clinic’s aims were reduction of stress, and alleviation, prevention of relapse and complete curing of the illness. Among the noteworthy changes in laboratory data of Case 1 are the remarkable increase in tumor immunity and lessening of the pain symptoms like back pain and lower back pain arising from metastasis to the bones. It may also be mentioned that there was low cancer cell accumulation in the bones and lungs as seen in the November 2003 PET images and there was no tumor enlargement in the pulmonary lymph nodes and axillary lymph nodes. These facts demonstrate the immunopotentiation action of fucoidan, and the reduction in pain and enhancement in QOL are very likely to be manifestations of its apoptotic action and inhibitory effect on neovascularization. However, as the levels of the breast cancer tumor marker CA15-3 and the uterine and ovarian tumor marker CA125 increased, the symptoms also gradually increased. The patient continued to follow the practices of the alternative therapies at the point of medical care until the last possible moment, mustering a strong will, and she requested that the course of her illness be documented and made available to others. Later, there was an increase in pleural effusion in her lungs and she had difficulty in breathing requiring her to be admitted to a




nearby hospital. She presented her case herself to a holistic medicine research group. Her case was included here, respecting her wish that her case study should be told to as many medical professionals as possible. The treatment resulted in prolongation of life without having to use the 3 conventional cancer therapies. It may be said that she showed others how to live accepting all the things that life offered. With Case 2, the fact that the 1 cm cancerous tumor in the right breast disappeared after about 6 months of treatment is worth mentioning. However, as the lymphocyte count became less than 1,000, it became important to continue to follow up the case. Case 3 is a patient who developed cancer in her 20’s and her condition required continued follow up. Her entire family appeared to have cancer genes. Her paternal grandfather had lung cancer, her father had stomach cancer, and her mother had breast cancer. Furthermore, considering that she was HPV positive also, the recommendation for a hysterectomy given by the first gynecologist she consulted is understandable. When viewed with hindsight the choice between forcible resection followed by suppression with drugs against the alternative of going for therapy that could lead to apoptosis, the second approach was indeed better. She was referred to and kept under observation by a doctor in a department of obstetrics and gynecology where she could undergo cervical conization if needed, and not a hysterectomy, while pursuing alternative therapies. She did not require conization and has now become the mother of three children. Case 4 was a male of advanced age. He chose his own therapy at an age beyond the average life expectancy. This attitude appeared to be in line with his value systems and the way he lived. Despite the disease being benign he underwent the major surgery of a total cystectomy and subsequent dialysis. It would seem that the family had no choice but to finally accept the course of his illness. With Case 5, the liver, a major organ like the kidney, was affected. Despite that the level of the tumor marker AFP came down from 605 to 333 ng/mg in one month of starting the treatment and to 97.6 ng/mg in 2 months, which is noteworthy. After one year of treatment, the QOL remained good. She led a wonderful life, contributing to the psychological care of others through magic tricks and counseling, which were her hobbies. Elements of the immunopotentiating action of low molecular weight fucoidan have been confirmed by the increase in TNF-α, interferon � and interleukin 12 in Case 1. After that the anti-p53 antibody level was also included as an indicator of the immunopotentiation effect in Case 8, a patient of Stage IV thyroid cancer. The lowered level of anti-p53 antibody in this patient suggested that apoptosis had occurred. With Case 10 also,

the anti-p53 antibody level which was higher than 500 fell to 8 or so, as mentioned earlier. With Case 6, where the cancer was treated for a long time with integrated therapy that included a combination of low molecular weight fucoidan administration, stellate ganglion block and Chinese herbal medicine, progress was reported, and the tumor markers have continued to show high levels. But the patient’s QOL remains good and follow up is continuing. In the future, improved blood flow to the hypothalamus through sympathetic nerve block as a way of stress management will be tried, using the Fukuda-Abo theory as the basis for evaluating the immune system and autonomic nerves. Case 2 had pancytopenia after 28 courses of anticancer chemotherapy, and Cases 5, 6 and 8 also had pancytopenia along with hepatitis C, liver cirrhosis or liver cancer. In spite of this, a therapeutic effect was seen, which suggests the importance of the apoptosis inducing effect of low molecular weight fucoidan. It is quite possible that blood flow into the hypothalamus improved because of the stellate ganglion block therapy and that the effective component of the therapy improved blood flow to the tumor affected parts. In Case 10 also, the level of anti-p53 antibody fell with the alternative therapy given when the patient’s leukocyte count was low perhaps due to the effect of one round of treatment with an anticancer agent. Therefore, this is an important case illustrating the apoptosis inducing effect. The arteriosclerosis data improved after 3-day fasting that the patient did as a part of integrated therapy. As this case simultaneously showed good data like improved ketone body cycle, accelerated plethysmogram and autonomic nerve regulation, the case is also included in this report. In the next report, I would like to discuss cases where the patient had undergone fasting, sugar restriction, etc. What is noteworthy about integrated therapy mainly using low molecular weight fucoidan supplements in terminal care is that the patient does not suffer much pain. This is probably because unlike the cachexia symptoms arising from cell necrosis as a result of the three conventional cancer therapies, in the case of apoptosis, the cells are phagocytosed when the cell membranes are still intact and much of the residual cancer cachexia and potassium, etc. from the cancer cells enters the blood stream. Control of serotonin levels and endorphin secretion brought about by qigong, breath work, and other activities are also probably contributing to pain control. In the present paper, additional data have been presented in continuation of what was reported earlier. In future papers, it would be good to report the detailed percent improvement of all the treated cases and discuss the action mechanisms. Shirahata et al. broadly classified




active substances in low molecular weight fucoidan extracts into “sugar chains”, “glycolipids”, “glycoproteins”, and “pigment components and others” for future study and mentioned that they would take up basic research to (1) elucidate activity and action mechanism of each component, (2) identify the apoptosis inducing factor and elucidate its action mechanism, (3) elucidate the mechanisms of absorption and of action of active components in low molecular weight fucoidan extracts, etc. Keeping the details of their research in mind, in the future, I would like to report on cancer cases, including those that showed very good response to the treatment, handling clinical patients as living entities that respond to mental and emotional treatments. Advances in psychoneuroimmunology are gradually and scientifically proving the old saying, “All illness comes from the mind”. Under this scenario, research on how to conceptualize cancers and overcome them are important and urgent issues for those diagnosed with cancer and are currently under treatment. I am in favor of creating as soon as possible a system of patient monitoring with the approach of comprehensive medicine. This system must combine immunocompetence evaluation based on lymphocyte count and percentage at the primary screening, a yet to be established secondary immunity evaluation by measuring tumor immunity (interleukin 12, interferon �, TNF-α, NK activity, TH1, TH2, and TH1/TH2 ratio), evaluation of tumor marker data, especially of anti-p53 antibody, and evaluation of PET data. Together with various physicians who are proponents of integrated medicine, I would like to work to realize medical care that protects the living body, encompassing the body, mind and spirit, using the aforesaid patient monitoring system.

Conclusion 1. Ten cases were reported that included information on

the progress of 5 cases that had been presented at the ISLIS meeting in South Korea in August 2004, 4 other cases that were under integrated therapy mainly with low molecular weight fucoidan for more than 5 years since being diagnosed with cancer, and one case under similar therapy for 3 years.

2. The patient died in 4 out of these 10 cases and in the remaining 6 the tumor has disappeared, tumor markers are showing a declining trend, or good QOL is being maintained.

3. Of the 4 patients who died, 3 had Stage IV cancer and 1 had Stage I. They all lived longer than initially predicted by physicians.

4. Of the 6 surviving patients, the 4 with Stage I cancers of the uterine cervix, prostate, or breast chose integrated medicine without ever having the three

conventional cancer treatments. 5. The remaining 2 survivors had Stage IV cancer

diagnosis. The patient with thyroid cancer metastasized to the neck did not have the three conventional cancer treatments while the patient with liver cancer tried the three conventional cancer treatments to the extent possible before opting for integrated therapy. These patients were discussed here as they have been making good progress.

6. The treatments other than the low molecular weight fucoidan supplements used in the present study were those that have been in use since the opening of the Nishimoto Clinic in June 1996, and improvements in them have been incorporated along the way. It is intended to examine new possibilities of treating intractable diseases through practical applications of new theories and long-term integrated therapies.

References

1) Nishimoto S, Mizoguchi S, Masuda K: Four patients of

post-herpes zoster neuralgia cured with qigong. Japanese Journal of Holistic Medicine, 4: 63-70, 1994. [in Japanese]

2) Nishimoto S: Report on autonomic nervous system changes and pain reduction evinced by patients administered external Qi therapy with alpha wave 1/f music. J. Intl Soc Life Info Sci., 14(2): 259-265, 1996.

3) Nishimoto S: Double blind test for HIGH-GENKI II and the report to treat 1 case of ulcerative colitis and to treat 10 cases of chronic hepatitis. Clinical Pharmacology and Therapy, 6(8): 1572-1576, 1996. [in Japanese]

4) Nishimoto S, Dobashi H, Yamanoguchi S: Relaxation effects and reduction of sharp pain by application of external Qi Gong. Science of Hypnotics, 17(1): 43-49, 2002. [in Japanese]

5) Nishimoto S: Report on changes in brain waves of the frontal lobe and in Ryodouraku measurement data caused by healing with energy-irradiated waters, rock crystal, etc. J. Intl Soc Life Info Sci., 20(2): 668-674, 2002.

6) Nishimoto S: Report on two cases where tumors have disappeared with relief of symptoms by healing with energy-irradiated waters, rock crystal, etc. J. Intl Soc Life Info Sci., 21(1): 151-158, 2003.

7) Abo T: Number and function of leukocytes is regulated by the autonomic nervous system. J. Intl Soc Life Info Sci., 20(1): 171-189, 2002. (in Japanese)

8) Holmes MD, Stampfer MJ Dietary factors and the survival of women with breast carcinoma. Cancer, 86: 826-835, 1999.

9) Meyer F, Bairati I Dietary fat and prostate cancer survival. Cancer Causes Control, 10: 245-251, 1999.

10) Herman C, Adlercrevfz T Soybean phytoestrogen intake and cancer risk. J Nutr., 125: 757-770, 1995.

11) Uno K: Senryakuteki Saibo Bunshi Men’eki Chiryo (Strategic Molecular Immunotherapy). Metamor Publishing, Tokyo 2002. (in Japanese)

12) Yu F, Sakai T, Kato I: Anti-tumor activity of fucoidan from K. crassifolia Miyabe against




azoxymethane-induced tumor and human colon cancer xenografts. The 55th Japanese Journal of Cancer Research, p71, 1996. (in Japanese)

13) Shirahata S: Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells. Bioscience, Biotechnology and Biochemistry, 77(2): 235-242, 2013. (in Japanese)

14) Nishimoto S: Clinical improvement in cancer patients through alternative medicine, mainly fucoidan. J. Intl Soc Life Info Sci., 22(2): 497-511, 2004.




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8) HolmesMD,StampferMJ Dietary factors and the survival of women with breast carcinoma. Cancer, 86: 826-835, 1999.

9) Meyer F , Bairati I Dietary fat and prostate cancer survival. Cancer Causes Control, 10: 245-251, 1999.

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