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1 Clinical Pathological Conference Three Interesting Cases of Abnormal Cervical Cytology 15 October 2001

Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 1: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

1

Clinical Pathological Conference

Three Interesting Cases of

Abnormal Cervical Cytology

15 October 2001

Page 2: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC13877 Cervical smear LP

shows papillary and villiform fragments of tumour cells

Page 3: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 4: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC13877 HP crowded cellular

fragment with gland opening and papillary projection.

Page 5: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 6: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC13877 HP - Another crowded

sheet with gland around.

Page 7: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 8: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC13877 HP view of one tightly

crowded sheets of tumour cells with frequent mitosis.

Page 9: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 10: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC13877 HP - Fragment shows

Pseudostratification of the nuclei.

Page 11: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 12: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC13877 Cell cluster with

Rosette formation.

Page 13: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 14: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KB6699 Cone biopsy show

adenocarcinoma in-situ in some of the sections.

Page 15: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 16: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KB6699 Cone biopsy HP shows

dilated glands lined by tumour cells with Pseudostratification of the nuclear.

Page 17: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 18: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KB6699 HP gland lined by

column tumour cells with elongated hyperchromatic nuclei

Page 19: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 20: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KB9922 Hysterectomy

specimen shows AIS in cervix.

Page 21: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 22: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KB9922 Hysterectomy

specimen HP shows crowded glands lined by columnar neoplastic cells.

Page 23: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 24: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC14694 Follow up smear show

fragments of tumour cells.

Page 25: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 26: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC14697 HP shows strips of

tumour cells with characteristics features of AIS.

Page 27: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 28: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC14694 Rosette arrangement

of tumour cells.

Page 29: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 30: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC14694 Strips of tumour cells

show characteristic Palisading and Pseudostratication of the nuclei as well as feathery edge.

Page 31: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 32: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KC17466 Repeat vault smear

shows persistent presence of tumour cells fragments.

Page 33: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Page 34: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

01KB9295 Vault stripping show

no tumour koilocytosis seen.

Page 35: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

In Summary

22/03/00 : CS – Suggestive of AIS

13/04/00 : CS & Cytobrush – AIS

13/04/00 : Cervical Biopsy – AIS

Page 37: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

28/04/00 : Cervical (LLETZ) Biopsy – AIS, margins involved

22/06/00 : THBSO, done – AIS, distal margins involved – Leiomyoma Right Ovary – Brenner tumour

Page 38: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

20/09/00 : Vault Smear – No tumour cell seen

20/12/00 : Vault Smear – Negative

18/04/01 : Vault Smear – Adenocarcinoma

09/05/01 : Vault Smear and Cytobrush from both angles – Adenocarcinoma

Page 39: Clinical Pathological Conference - HKSCCP Notes/CPC 2001.10.15, lecture 1a.pdfCervical smear LP shows papillary and villiform fragments of tumour cells . 3 . 4 Clinical Pathological

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Clinical Pathological Conference

19/05/01 : Vaginal Biopsy – Condyloma

01/06/01 : Vaginal Vault Stripping – Flat Condyloma

18/07/01 : Vault Smear – Negative

19/09/01 : Vault Smear – Negative

- END -