Cluster 1 ID Name p-value q-value Bonferroniq-value FDR B&HACAN GO:0050778positive regulation of immune response 8.66E-08 0.000125 0.000108ANK3 GO:0002757immune response-activating signal transduction 1.49E-07 0.000216 0.000108SYTL2 GO:0002764immune response-regulating signaling pathway 2.44E-07 0.000353 0.000118STARD5 GO:0002253activation of immune response 3.3E-07 0.000478 0.000119C15orf5 GO:0006955immune response 4.16E-07 0.000601 0.00012RPL21P44 GO:0050776regulation of immune response 8.12E-07 0.001174 0.000196SAMD9 GO:0032647regulation of interferon-alpha production 1.15E-06 0.001669 0.000238IFIH1 GO:0032607interferon-alpha production 1.33E-06 0.001918 0.00024SMC6 GO:0002684positive regulation of immune system process 1.51E-06 0.002186 0.000243CDH6 GO:0001819positive regulation of cytokine production 1.82E-06 0.002634 0.000263FKBP11 GO:0031349positive regulation of defense response 2.06E-06 0.002981 0.000271PAG1 GO:0006954inflammatory response 2.53E-06 0.003656 0.000305CLDN1 GO:0032675regulation of interleukin-6 production 5E-06 0.007225 0.000556FCGR1A GO:0032635interleukin-6 production 6.05E-06 0.008743 0.000625LY86 GO:0006952defense response 7.68E-06 0.0111 0.000721TLR7 GO:0045087innate immune response 7.98E-06 0.01154 0.000721TLR1 GO:0032103positive regulation of response to external stimulus1.17E-05 0.01687 0.000992CD300A GO:0034154toll-like receptor 7 signaling pathway 1.32E-05 0.01909 0.001061HAVCR2 GO:0034110regulation of homotypic cell-cell adhesion 1.55E-05 0.02245 0.001165CLEC5A GO:0002221pattern recognition receptor signaling pathway 1.61E-05 0.0233 0.001165IL1B GO:0050707regulation of cytokine secretion 1.9E-05 0.02746 0.00121

GO:0001817regulation of cytokine production 1.94E-05 0.02799 0.00121GO:0098609cell-cell adhesion 2.09E-05 0.03017 0.00121GO:0043207response to external biotic stimulus 2.17E-05 0.03139 0.00121GO:0051707response to other organism 2.17E-05 0.03139 0.00121GO:0071219cellular response to molecule of bacterial origin 2.18E-05 0.03145 0.00121GO:0032722positive regulation of chemokine production 2.38E-05 0.03445 0.001221GO:0060341regulation of cellular localization 0.000024 0.0347 0.001221GO:0002274myeloid leukocyte activation 2.48E-05 0.03585 0.001221GO:0002703regulation of leukocyte mediated immunity 2.53E-05 0.03662 0.001221GO:0009607response to biotic stimulus 2.83E-05 0.04087 0.001293GO:0042116macrophage activation 2.9E-05 0.04198 0.001293GO:0034109homotypic cell-cell adhesion 3.11E-05 0.04491 0.001293GO:0050663cytokine secretion 3.12E-05 0.04506 0.001293GO:0045410positive regulation of interleukin-6 biosynthetic process3.16E-05 0.04575 0.001293GO:0051049regulation of transport 3.32E-05 0.04796 0.001293GO:0071216cellular response to biotic stimulus 3.38E-05 0.0488 0.001293GO:0001816cytokine production 3.48E-05 0.0503 0.001293GO:0051050positive regulation of transport 3.49E-05 0.05043 0.001293GO:0042108positive regulation of cytokine biosynthetic process3.65E-05 0.05283 0.001321GO:0002682regulation of immune system process 3.76E-05 0.05434 0.001325GO:0007155cell adhesion 4.21E-05 0.06093 0.001441GO:0022407regulation of cell-cell adhesion 4.29E-05 0.06196 0.001441GO:0022610biological adhesion 4.46E-05 0.06447 0.001465GO:1903530regulation of secretion by cell 4.9E-05 0.07081 0.001541GO:0032729positive regulation of interferon-gamma production 4.9E-05 0.07088 0.001541GO:0032755positive regulation of interleukin-6 production 5.3E-05 0.07669 0.001632GO:0032642regulation of chemokine production 6.4E-05 0.09256 0.001928GO:0051046regulation of secretion 7.34E-05 0.1062 0.002134GO:0050764regulation of phagocytosis 7.38E-05 0.1067 0.002134GO:0032602chemokine production 7.9E-05 0.1143 0.002214GO:0002758innate immune response-activating signal transduction8.11E-05 0.1173 0.002214GO:0051223regulation of protein transport 8.14E-05 0.1177 0.002214GO:0010647positive regulation of cell communication 8.4E-05 0.1215 0.002214GO:0031347regulation of defense response 8.42E-05 0.1218 0.002214GO:0045321leukocyte activation 8.89E-05 0.1285 0.002254GO:0002218activation of innate immune response 9.17E-05 0.1326 0.002254

GO:1905153regulation of membrane invagination 9.2E-05 0.133 0.002254GO:0060099regulation of phagocytosis, engulfment 9.2E-05 0.133 0.002254GO:0051222positive regulation of protein transport 9.37E-05 0.1354 0.002257GO:0002252immune effector process 0.000104 0.1496 0.002453GO:0045408regulation of interleukin-6 biosynthetic process 0.000119 0.172 0.002733GO:0050868negative regulation of T cell activation 0.000119 0.1722 0.002733GO:0032727positive regulation of interferon-alpha production 0.000134 0.1934 0.003003GO:0070201regulation of establishment of protein localization 0.000135 0.1952 0.003003GO:0042035regulation of cytokine biosynthetic process 0.000145 0.2101 0.003183GO:0042226interleukin-6 biosynthetic process 0.000149 0.2161 0.003225GO:1903038negative regulation of leukocyte cell-cell adhesion 0.000153 0.2218 0.003262GO:1904951positive regulation of establishment of protein localization0.000156 0.2254 0.003266GO:0034162toll-like receptor 9 signaling pathway 0.000166 0.2399 0.003383GO:0032649regulation of interferon-gamma production 0.000166 0.2402 0.003383GO:0050715positive regulation of cytokine secretion 0.00018 0.2595 0.003503GO:0045089positive regulation of innate immune response 0.00018 0.2604 0.003503GO:0001774microglial cell activation 0.000183 0.265 0.003503GO:0034111negative regulation of homotypic cell-cell adhesion0.000184 0.2662 0.003503GO:0032479regulation of type I interferon production 0.000184 0.2662 0.003503GO:0009617response to bacterium 0.000191 0.2759 0.003583GO:0032606type I interferon production 0.000194 0.2799 0.003588GO:0042089cytokine biosynthetic process 0.000198 0.2869 0.003631GO:0042107cytokine metabolic process 0.000208 0.3012 0.003765GO:0002224toll-like receptor signaling pathway 0.000219 0.316 0.003899GO:0098542defense response to other organism 0.000221 0.3199 0.003899GO:0032609interferon-gamma production 0.000224 0.3236 0.003899GO:0050863regulation of T cell activation 0.000235 0.3399 0.004046GO:0001775cell activation 0.000252 0.3647 0.004291GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.000257 0.3715 0.004317GO:0002706regulation of lymphocyte mediated immunity 0.000263 0.3799 0.004317GO:0050729positive regulation of inflammatory response 0.000263 0.3799 0.004317GO:1903037regulation of leukocyte cell-cell adhesion 0.000276 0.3989 0.004482GO:0051250negative regulation of lymphocyte activation 0.000287 0.4148 0.004609GO:0009967positive regulation of signal transduction 0.000297 0.4291 0.004716GO:0002443leukocyte mediated immunity 0.000325 0.4699 0.005107GO:0002237response to molecule of bacterial origin 0.000332 0.48 0.005114GO:0002819regulation of adaptive immune response 0.000332 0.4807 0.005114GO:0032880regulation of protein localization 0.000339 0.49 0.005158GO:0043271negative regulation of ion transport 0.000346 0.5007 0.005216GO:0045088regulation of innate immune response 0.000396 0.5724 0.005901GO:0032940secretion by cell 0.0004 0.5785 0.005903GO:0032728positive regulation of interferon-beta production 0.00043 0.6221 0.006255GO:0030155regulation of cell adhesion 0.000433 0.6255 0.006255GO:0022408negative regulation of cell-cell adhesion 0.000437 0.632 0.006257GO:0002695negative regulation of leukocyte activation 0.000454 0.6558 0.00643GO:0051240positive regulation of multicellular organismal process0.000482 0.6974 0.006757GO:0002755MyD88-dependent toll-like receptor signaling pathway0.000486 0.7028 0.006757GO:0002250adaptive immune response 0.000515 0.7445 0.007028GO:0002675positive regulation of acute inflammatory response0.000515 0.7449 0.007028GO:0071222cellular response to lipopolysaccharide 0.000551 0.7972 0.007451GO:0023056positive regulation of signaling 0.000586 0.8469 0.007842GO:1901224positive regulation of NIK/NF-kappaB signaling 0.000608 0.8786 0.008061GO:0050866negative regulation of cell activation 0.000641 0.9264 0.008422GO:0002699positive regulation of immune effector process 0.000705 1 0.009186GO:1903036positive regulation of response to wounding 0.000739 1 0.009433GO:1903792negative regulation of anion transport 0.000743 1 0.009433GO:0050708regulation of protein secretion 0.000748 1 0.009433GO:0051249regulation of lymphocyte activation 0.000754 1 0.009433

GO:0046903secretion 0.000757 1 0.009433GO:0032480negative regulation of type I interferon production 0.000778 1 0.009619GO:0051047positive regulation of secretion 0.000786 1 0.009637GO:0032757positive regulation of interleukin-8 production 0.000891 1 0.01031GO:0002697regulation of immune effector process 0.000896 1 0.01031GO:0034130toll-like receptor 1 signaling pathway 0.000967 1 0.01031GO:0071656negative regulation of granulocyte colony-stimulating factor production0.000967 1 0.01031GO:0002838negative regulation of immune response to tumor cell0.000967 1 0.01031GO:0071414cellular response to methotrexate 0.000967 1 0.01031GO:0002859negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target0.000967 1 0.01031GO:1900827positive regulation of membrane depolarization during cardiac muscle cell action potential0.000967 1 0.01031GO:0051134negative regulation of NK T cell activation 0.000967 1 0.01031GO:0035504regulation of myosin light chain kinase activity 0.000967 1 0.01031GO:0035505positive regulation of myosin light chain kinase activity0.000967 1 0.01031GO:0002552serotonin secretion by mast cell 0.000967 1 0.01031GO:0032712negative regulation of interleukin-3 production 0.000967 1 0.01031GO:0002835negative regulation of response to tumor cell 0.000967 1 0.01031GO:0002856negative regulation of natural killer cell mediated immune response to tumor cell0.000967 1 0.01031GO:1901257negative regulation of macrophage colony-stimulating factor production0.000967 1 0.01031GO:0032648regulation of interferon-beta production 0.000969 1 0.01031GO:0002833positive regulation of response to biotic stimulus 0.000969 1 0.01031GO:0032608interferon-beta production 0.001052 1 0.01102GO:0002886regulation of myeloid leukocyte mediated immunity0.001052 1 0.01102GO:0050670regulation of lymphocyte proliferation 0.001179 1 0.0122GO:1901222regulation of NIK/NF-kappaB signaling 0.001181 1 0.0122GO:0032944regulation of mononuclear cell proliferation 0.00121 1 0.01231GO:0070489T cell aggregation 0.001217 1 0.01231GO:0042110T cell activation 0.001217 1 0.01231GO:0071593lymphocyte aggregation 0.001226 1 0.01231GO:0060627regulation of vesicle-mediated transport 0.001235 1 0.01232GO:0002694regulation of leukocyte activation 0.001253 1 0.01237GO:0030100regulation of endocytosis 0.001258 1 0.01237GO:0002704negative regulation of leukocyte mediated immunity0.001271 1 0.01242GO:0070486leukocyte aggregation 0.00129 1 0.01252GO:0032663regulation of interleukin-2 production 0.001317 1 0.01253GO:0006911phagocytosis, engulfment 0.001317 1 0.01253GO:0031663lipopolysaccharide-mediated signaling pathway 0.001317 1 0.01253GO:0070663regulation of leukocyte proliferation 0.001373 1 0.01298GO:0002437inflammatory response to antigenic stimulus 0.001413 1 0.01326GO:0034112positive regulation of homotypic cell-cell adhesion0.001424 1 0.01329GO:0050766positive regulation of phagocytosis 0.001461 1 0.01354GO:0015031protein transport 0.001521 1 0.01401GO:0009306protein secretion 0.001569 1 0.01436GO:0032677regulation of interleukin-8 production 0.001612 1 0.01466GO:0007159leukocyte cell-cell adhesion 0.001634 1 0.01476GO:0050865regulation of cell activation 0.001656 1 0.01485GO:0032623interleukin-2 production 0.001664 1 0.01485GO:0007162negative regulation of cell adhesion 0.00168 1 0.01491GO:1902533positive regulation of intracellular signal transduction0.001742 1 0.01521GO:0050714positive regulation of protein secretion 0.001778 1 0.01521GO:0006909phagocytosis 0.001778 1 0.01521GO:0010324membrane invagination 0.001825 1 0.01521GO:0019742pentacyclic triterpenoid metabolic process 0.001932 1 0.01521GO:0060101negative regulation of phagocytosis, engulfment 0.001932 1 0.01521GO:1902567negative regulation of eosinophil activation 0.001932 1 0.01521GO:2000417negative regulation of eosinophil migration 0.001932 1 0.01521GO:0002519natural killer cell tolerance induction 0.001932 1 0.01521GO:0001788antibody-dependent cellular cytotoxicity 0.001932 1 0.01521

GO:0036270response to diuretic 0.001932 1 0.01521GO:0010650positive regulation of cell communication by electrical coupling0.001932 1 0.01521GO:0072658maintenance of protein location in membrane 0.001932 1 0.01521GO:0072660maintenance of protein location in plasma membrane0.001932 1 0.01521GO:2000521negative regulation of immunological synapse formation0.001932 1 0.01521GO:0042495detection of triacyl bacterial lipopeptide 0.001932 1 0.01521GO:0002652regulation of tolerance induction dependent upon immune response0.001932 1 0.01521GO:1902569negative regulation of activation of Janus kinase activity0.001932 1 0.01521GO:1905154negative regulation of membrane invagination 0.001932 1 0.01521GO:0006722triterpenoid metabolic process 0.001932 1 0.01521GO:0032637interleukin-8 production 0.001935 1 0.01521GO:0090316positive regulation of intracellular protein transport0.002093 1 0.01636GO:0002449lymphocyte mediated immunity 0.002115 1 0.01644GO:0042742defense response to bacterium 0.002137 1 0.01653GO:0032760positive regulation of tumor necrosis factor production0.002167 1 0.01658GO:0032481positive regulation of type I interferon production 0.002167 1 0.01658GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.002205 1 0.01678GO:0022409positive regulation of cell-cell adhesion 0.002228 1 0.01686GO:0032101regulation of response to external stimulus 0.002239 1 0.01686GO:1903557positive regulation of tumor necrosis factor superfamily cytokine production0.002287 1 0.01714GO:0050672negative regulation of lymphocyte proliferation 0.002473 1 0.01834GO:0032945negative regulation of mononuclear cell proliferation0.002473 1 0.01834GO:0002275myeloid cell activation involved in immune response0.002667 1 0.01878GO:0032612interleukin-1 production 0.002667 1 0.01878GO:0043407negative regulation of MAP kinase activity 0.002667 1 0.01878GO:0080134regulation of response to stress 0.002798 1 0.01878GO:0070664negative regulation of leukocyte proliferation 0.002799 1 0.01878GO:0046651lymphocyte proliferation 0.002849 1 0.01878GO:0002673regulation of acute inflammatory response 0.002867 1 0.01878GO:0002708positive regulation of lymphocyte mediated immunity0.002867 1 0.01878GO:0071260cellular response to mechanical stimulus 0.002867 1 0.01878GO:0036273response to statin 0.002897 1 0.01878GO:2000520regulation of immunological synapse formation 0.002897 1 0.01878GO:0070340detection of bacterial lipopeptide 0.002897 1 0.01878GO:1902564negative regulation of neutrophil activation 0.002897 1 0.01878GO:2001189negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell0.002897 1 0.01878GO:0071725response to triacyl bacterial lipopeptide 0.002897 1 0.01878GO:0071611granulocyte colony-stimulating factor production 0.002897 1 0.01878GO:0071727cellular response to triacyl bacterial lipopeptide 0.002897 1 0.01878GO:0034343type III interferon production 0.002897 1 0.01878GO:0060557positive regulation of vitamin D biosynthetic process0.002897 1 0.01878GO:0038123toll-like receptor TLR1:TLR2 signaling pathway 0.002897 1 0.01878GO:2000173negative regulation of branching morphogenesis of a nerve0.002897 1 0.01878GO:0060559positive regulation of calcidiol 1-monooxygenase activity0.002897 1 0.01878GO:0046136positive regulation of vitamin metabolic process 0.002897 1 0.01878GO:0032672regulation of interleukin-3 production 0.002897 1 0.01878GO:0071655regulation of granulocyte colony-stimulating factor production0.002897 1 0.01878GO:0034344regulation of type III interferon production 0.002897 1 0.01878GO:1900425negative regulation of defense response to bacterium0.002897 1 0.01878GO:0002461tolerance induction dependent upon immune response0.002897 1 0.01878GO:0032943mononuclear cell proliferation 0.00293 1 0.01892GO:0002824positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.003004 1 0.01931GO:0032147activation of protein kinase activity 0.003269 1 0.02091GO:1903533regulation of protein targeting 0.003327 1 0.02119GO:0070661leukocyte proliferation 0.003387 1 0.02148GO:0032386regulation of intracellular transport 0.003414 1 0.02156GO:0002444myeloid leukocyte mediated immunity 0.003508 1 0.02172GO:0002821positive regulation of adaptive immune response 0.003508 1 0.02172

GO:0002429immune response-activating cell surface receptor signaling pathway0.003756 1 0.02172GO:0070164negative regulation of adiponectin secretion 0.003861 1 0.02172GO:0042494detection of bacterial lipoprotein 0.003861 1 0.02172GO:0002445type II hypersensitivity 0.003861 1 0.02172GO:1902566regulation of eosinophil activation 0.003861 1 0.02172GO:0001802type III hypersensitivity 0.003861 1 0.02172GO:0032687negative regulation of interferon-alpha production 0.003861 1 0.02172GO:0032632interleukin-3 production 0.003861 1 0.02172GO:1901256regulation of macrophage colony-stimulating factor production0.003861 1 0.02172GO:0071139resolution of recombination intermediates 0.003861 1 0.02172GO:0002351serotonin production involved in inflammatory response0.003861 1 0.02172GO:1900825regulation of membrane depolarization during cardiac muscle cell action potential0.003861 1 0.02172GO:0014805smooth muscle adaptation 0.003861 1 0.02172GO:0045356positive regulation of interferon-alpha biosynthetic process0.003861 1 0.02172GO:0001794type IIa hypersensitivity 0.003861 1 0.02172GO:0002892regulation of type II hypersensitivity 0.003861 1 0.02172GO:0036301macrophage colony-stimulating factor production 0.003861 1 0.02172GO:0002442serotonin secretion involved in inflammatory response0.003861 1 0.02172GO:1904469positive regulation of tumor necrosis factor secretion0.003861 1 0.02172GO:0033092positive regulation of immature T cell proliferation in thymus0.003861 1 0.02172GO:0001798positive regulation of type IIa hypersensitivity 0.003861 1 0.02172GO:0030886negative regulation of myeloid dendritic cell activation0.003861 1 0.02172GO:0002894positive regulation of type II hypersensitivity 0.003861 1 0.02172GO:0001805positive regulation of type III hypersensitivity 0.003861 1 0.02172GO:0001803regulation of type III hypersensitivity 0.003861 1 0.02172GO:0001796regulation of type IIa hypersensitivity 0.003861 1 0.02172GO:0044092negative regulation of molecular function 0.003979 1 0.0223GO:0050727regulation of inflammatory response 0.004049 1 0.0226GO:0032496response to lipopolysaccharide 0.004082 1 0.0227GO:0046649lymphocyte activation 0.00416 1 0.02305GO:0001909leukocyte mediated cytotoxicity 0.004375 1 0.02414GO:0042307positive regulation of protein import into nucleus 0.004627 1 0.02534GO:0002705positive regulation of leukocyte mediated immunity0.004627 1 0.02534GO:0042102positive regulation of T cell proliferation 0.004712 1 0.02546GO:0019220regulation of phosphate metabolic process 0.004776 1 0.02546GO:0050859negative regulation of B cell receptor signaling pathway0.004824 1 0.02546GO:0071726cellular response to diacyl bacterial lipopeptide 0.004824 1 0.02546GO:0002439chronic inflammatory response to antigenic stimulus0.004824 1 0.02546GO:0033091positive regulation of immature T cell proliferation0.004824 1 0.02546GO:0098902regulation of membrane depolarization during action potential0.004824 1 0.02546GO:2001188regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell0.004824 1 0.02546GO:0070487monocyte aggregation 0.004824 1 0.02546GO:0071724response to diacyl bacterial lipopeptide 0.004824 1 0.02546GO:1904591positive regulation of protein import 0.004885 1 0.02569GO:0002768immune response-regulating cell surface receptor signaling pathway0.004934 1 0.02585GO:0051174regulation of phosphorus metabolic process 0.004955 1 0.02587GO:0018193peptidyl-amino acid modification 0.005374 1 0.02783GO:0006024glycosaminoglycan biosynthetic process 0.005422 1 0.02783GO:0006023aminoglycan biosynthetic process 0.005514 1 0.02783GO:0002698negative regulation of immune effector process 0.005514 1 0.02783GO:1903829positive regulation of cellular protein localization 0.005598 1 0.02783GO:1903510mucopolysaccharide metabolic process 0.0057 1 0.02783GO:0071220cellular response to bacterial lipoprotein 0.005786 1 0.02783GO:0035634response to stilbenoid 0.005786 1 0.02783GO:1902563regulation of neutrophil activation 0.005786 1 0.02783GO:0070162adiponectin secretion 0.005786 1 0.02783GO:0031427response to methotrexate 0.005786 1 0.02783GO:0014063negative regulation of serotonin secretion 0.005786 1 0.02783

GO:0071221cellular response to bacterial lipopeptide 0.005786 1 0.02783GO:0070339response to bacterial lipopeptide 0.005786 1 0.02783GO:2000172regulation of branching morphogenesis of a nerve 0.005786 1 0.02783GO:2000416regulation of eosinophil migration 0.005786 1 0.02783GO:0060355positive regulation of cell adhesion molecule production0.005786 1 0.02783GO:0045354regulation of interferon-alpha biosynthetic process0.005786 1 0.02783GO:0045349interferon-alpha biosynthetic process 0.005786 1 0.02783GO:0009597detection of virus 0.005786 1 0.02783GO:0070163regulation of adiponectin secretion 0.005786 1 0.02783GO:0038061NIK/NF-kappaB signaling 0.005794 1 0.02783GO:0034754cellular hormone metabolic process 0.005794 1 0.02783GO:0031503protein-containing complex localization 0.005794 1 0.02783GO:0046718viral entry into host cell 0.005889 1 0.0282GO:0031399regulation of protein modification process 0.006036 1 0.02863GO:0032388positive regulation of intracellular transport 0.006141 1 0.02863GO:0052126movement in host environment 0.006178 1 0.02863GO:0044409entry into host 0.006178 1 0.02863GO:0051828entry into other organism involved in symbiotic interaction0.006178 1 0.02863GO:0097530granulocyte migration 0.006178 1 0.02863GO:0032680regulation of tumor necrosis factor production 0.006178 1 0.02863GO:0030260entry into host cell 0.006178 1 0.02863GO:0051806entry into cell of other organism involved in symbiotic interaction0.006178 1 0.02863GO:0052192movement in environment of other organism involved in symbiotic interaction0.006178 1 0.02863GO:0032640tumor necrosis factor production 0.006275 1 0.02899GO:0033157regulation of intracellular protein transport 0.006446 1 0.02968GO:1903555regulation of tumor necrosis factor superfamily cytokine production0.006473 1 0.02971GO:0046824positive regulation of nucleocytoplasmic transport 0.006673 1 0.03002GO:0043305negative regulation of mast cell degranulation 0.006747 1 0.03002GO:0033591response to L-ascorbic acid 0.006747 1 0.03002GO:0002826negative regulation of T-helper 1 type immune response0.006747 1 0.03002GO:0010193response to ozone 0.006747 1 0.03002GO:0045359positive regulation of interferon-beta biosynthetic process0.006747 1 0.03002GO:0032493response to bacterial lipoprotein 0.006747 1 0.03002GO:1904467regulation of tumor necrosis factor secretion 0.006747 1 0.03002GO:0060558regulation of calcidiol 1-monooxygenase activity 0.006747 1 0.03002GO:0071286cellular response to magnesium ion 0.006747 1 0.03002GO:0071706tumor necrosis factor superfamily cytokine production0.006774 1 0.03005GO:1903532positive regulation of secretion by cell 0.007083 1 0.03132GO:0002683negative regulation of immune system process 0.007224 1 0.03185GO:0045807positive regulation of endocytosis 0.007291 1 0.03195GO:0001906cell killing 0.007291 1 0.03195GO:0045785positive regulation of cell adhesion 0.007463 1 0.03244GO:0071901negative regulation of protein serine/threonine kinase activity0.007503 1 0.03244GO:0018205peptidyl-lysine modification 0.007511 1 0.03244GO:0010921regulation of phosphatase activity 0.007609 1 0.03244GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway0.007708 1 0.03244GO:1990774tumor necrosis factor secretion 0.007708 1 0.03244GO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell0.007708 1 0.03244GO:0030885regulation of myeloid dendritic cell activation 0.007708 1 0.03244GO:0045416positive regulation of interleukin-8 biosynthetic process0.007708 1 0.03244GO:0002885positive regulation of hypersensitivity 0.007708 1 0.03244GO:0043307eosinophil activation 0.007708 1 0.03244GO:0060353regulation of cell adhesion molecule production 0.007708 1 0.03244GO:0033007negative regulation of mast cell activation involved in immune response0.007708 1 0.03244GO:1900182positive regulation of protein localization to nucleus0.007717 1 0.03244GO:0016925protein sumoylation 0.007934 1 0.03316GO:0050777negative regulation of immune response 0.007934 1 0.03316GO:0050671positive regulation of lymphocyte proliferation 0.008044 1 0.03352

GO:0032946positive regulation of mononuclear cell proliferation0.008265 1 0.03434GO:1903305regulation of regulated secretory pathway 0.008376 1 0.03471GO:0030638polyketide metabolic process 0.008667 1 0.03511GO:0051133regulation of NK T cell activation 0.008667 1 0.03511GO:0002866positive regulation of acute inflammatory response to antigenic stimulus0.008667 1 0.03511GO:0032815negative regulation of natural killer cell activation 0.008667 1 0.03511GO:0039530MDA-5 signaling pathway 0.008667 1 0.03511GO:0014050negative regulation of glutamate secretion 0.008667 1 0.03511GO:0035234ectopic germ cell programmed cell death 0.008667 1 0.03511GO:0060556regulation of vitamin D biosynthetic process 0.008667 1 0.03511GO:0070665positive regulation of leukocyte proliferation 0.008945 1 0.03613GO:0001932regulation of protein phosphorylation 0.009035 1 0.03639GO:0002855regulation of natural killer cell mediated immune response to tumor cell0.009626 1 0.03682GO:0010533regulation of activation of Janus kinase activity 0.009626 1 0.03682GO:0033084regulation of immature T cell proliferation in thymus0.009626 1 0.03682GO:0070257positive regulation of mucus secretion 0.009626 1 0.03682GO:1900426positive regulation of defense response to bacterium0.009626 1 0.03682GO:0034116positive regulation of heterotypic cell-cell adhesion0.009626 1 0.03682GO:0060352cell adhesion molecule production 0.009626 1 0.03682GO:0045357regulation of interferon-beta biosynthetic process 0.009626 1 0.03682GO:0045350interferon-beta biosynthetic process 0.009626 1 0.03682GO:0014062regulation of serotonin secretion 0.009626 1 0.03682GO:1903817negative regulation of voltage-gated potassium channel activity0.009626 1 0.03682GO:0071639positive regulation of monocyte chemotactic protein-1 production0.009626 1 0.03682GO:0033129positive regulation of histone phosphorylation 0.009626 1 0.03682GO:0002858regulation of natural killer cell mediated cytotoxicity directed against tumor cell target0.009626 1 0.03682GO:0002423natural killer cell mediated immune response to tumor cell0.009626 1 0.03682GO:0002420natural killer cell mediated cytotoxicity directed against tumor cell target0.009626 1 0.03682GO:1902260negative regulation of delayed rectifier potassium channel activity0.009626 1 0.03682GO:0002887negative regulation of myeloid leukocyte mediated immunity0.009626 1 0.03682GO:0045080positive regulation of chemokine biosynthetic process0.009626 1 0.03682GO:1903034regulation of response to wounding 0.009944 1 0.03794GO:0002526acute inflammatory response 0.01013 1 0.03856GO:0035304regulation of protein dephosphorylation 0.01038 1 0.03939GO:0008037cell recognition 0.0105 1 0.03944GO:0033004negative regulation of mast cell activation 0.01058 1 0.03944GO:0033080immature T cell proliferation in thymus 0.01058 1 0.03944GO:0048755branching morphogenesis of a nerve 0.01058 1 0.03944GO:0002883regulation of hypersensitivity 0.01058 1 0.03944GO:0031622positive regulation of fever generation 0.01058 1 0.03944GO:0007016cytoskeletal anchoring at plasma membrane 0.01058 1 0.03944GO:0043409negative regulation of MAPK cascade 0.011 1 0.0408GO:0044070regulation of anion transport 0.011 1 0.0408GO:0030203glycosaminoglycan metabolic process 0.01113 1 0.0409GO:0035303regulation of dephosphorylation 0.01113 1 0.0409GO:0043902positive regulation of multi-organism process 0.01126 1 0.0409GO:0045860positive regulation of protein kinase activity 0.01138 1 0.0409GO:1905155positive regulation of membrane invagination 0.01154 1 0.0409GO:0002281macrophage activation involved in immune response0.01154 1 0.0409GO:0002863positive regulation of inflammatory response to antigenic stimulus0.01154 1 0.0409GO:0048711positive regulation of astrocyte differentiation 0.01154 1 0.0409GO:1903140regulation of establishment of endothelial barrier 0.01154 1 0.0409GO:0033083regulation of immature T cell proliferation 0.01154 1 0.0409GO:0042368vitamin D biosynthetic process 0.01154 1 0.0409GO:0042340keratan sulfate catabolic process 0.01154 1 0.0409GO:0060100positive regulation of phagocytosis, engulfment 0.01154 1 0.0409GO:0045414regulation of interleukin-8 biosynthetic process 0.01154 1 0.0409GO:0031620regulation of fever generation 0.01154 1 0.0409

GO:1901550regulation of endothelial cell development 0.01154 1 0.0409GO:0032490detection of molecule of bacterial origin 0.01154 1 0.0409GO:0043301negative regulation of leukocyte degranulation 0.01154 1 0.0409GO:0006694steroid biosynthetic process 0.01164 1 0.04117GO:0051701interaction with host 0.01177 1 0.04153GO:0042129regulation of T cell proliferation 0.01191 1 0.04183GO:0001934positive regulation of protein phosphorylation 0.01198 1 0.04183GO:0097529myeloid leukocyte migration 0.01204 1 0.04183GO:0050852T cell receptor signaling pathway 0.01217 1 0.04183GO:0042325regulation of phosphorylation 0.0122 1 0.04183GO:0002685regulation of leukocyte migration 0.0123 1 0.04183GO:0006022aminoglycan metabolic process 0.0123 1 0.04183GO:0016192vesicle-mediated transport 0.01233 1 0.04183GO:0071900regulation of protein serine/threonine kinase activity0.01246 1 0.04183GO:1904181positive regulation of membrane depolarization 0.0125 1 0.04183GO:0033079immature T cell proliferation 0.0125 1 0.04183GO:0042228interleukin-8 biosynthetic process 0.0125 1 0.04183GO:0070255regulation of mucus secretion 0.0125 1 0.04183GO:0045073regulation of chemokine biosynthetic process 0.0125 1 0.04183GO:0010960magnesium ion homeostasis 0.0125 1 0.04183GO:0042535positive regulation of tumor necrosis factor biosynthetic process0.0125 1 0.04183GO:0080184response to phenylpropanoid 0.0125 1 0.04183GO:0002524hypersensitivity 0.0125 1 0.04183GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production0.0125 1 0.04183GO:0010649regulation of cell communication by electrical coupling0.0125 1 0.04183GO:0030656regulation of vitamin metabolic process 0.0125 1 0.04183GO:0032308positive regulation of prostaglandin secretion 0.0125 1 0.04183GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling0.01298 1 0.04333GO:0051051negative regulation of transport 0.01326 1 0.04371GO:0031652positive regulation of heat generation 0.01345 1 0.04371GO:0033089positive regulation of T cell differentiation in thymus0.01345 1 0.04371GO:0051132NK T cell activation 0.01345 1 0.04371GO:0042033chemokine biosynthetic process 0.01345 1 0.04371GO:0032306regulation of prostaglandin secretion 0.01345 1 0.04371GO:2000400positive regulation of thymocyte aggregation 0.01345 1 0.04371GO:0045078positive regulation of interferon-gamma biosynthetic process0.01345 1 0.04371GO:0001771immunological synapse formation 0.01345 1 0.04371GO:0045838positive regulation of membrane potential 0.01345 1 0.04371GO:0045086positive regulation of interleukin-2 biosynthetic process0.01345 1 0.04371GO:1900424regulation of defense response to bacterium 0.01345 1 0.04371GO:0033674positive regulation of kinase activity 0.0136 1 0.0441GO:0042306regulation of protein import into nucleus 0.01395 1 0.04499GO:0042327positive regulation of phosphorylation 0.01396 1 0.04499GO:0070374positive regulation of ERK1 and ERK2 cascade 0.01423 1 0.04499GO:0030213hyaluronan biosynthetic process 0.01441 1 0.04499GO:0051956negative regulation of amino acid transport 0.01441 1 0.04499GO:0051044positive regulation of membrane protein ectodomain proteolysis0.01441 1 0.04499GO:0030730sequestering of triglyceride 0.01441 1 0.04499GO:0032645regulation of granulocyte macrophage colony-stimulating factor production0.01441 1 0.04499GO:0007252I-kappaB phosphorylation 0.01441 1 0.04499GO:0050755chemokine metabolic process 0.01441 1 0.04499GO:0045351type I interferon biosynthetic process 0.01441 1 0.04499GO:0001660fever generation 0.01441 1 0.04499GO:0045760positive regulation of action potential 0.01441 1 0.04499GO:0002864regulation of acute inflammatory response to antigenic stimulus0.01441 1 0.04499GO:2000651positive regulation of sodium ion transmembrane transporter activity0.01441 1 0.04499GO:0032604granulocyte macrophage colony-stimulating factor production0.01441 1 0.04499GO:0033127regulation of histone phosphorylation 0.01441 1 0.04499

GO:1904589regulation of protein import 0.01451 1 0.04523GO:0042976activation of Janus kinase activity 0.01536 1 0.04686GO:0002834regulation of response to tumor cell 0.01536 1 0.04686GO:0050765negative regulation of phagocytosis 0.01536 1 0.04686GO:0043032positive regulation of macrophage activation 0.01536 1 0.04686GO:0002837regulation of immune response to tumor cell 0.01536 1 0.04686GO:0001820serotonin secretion 0.01536 1 0.04686GO:0031650regulation of heat generation 0.01536 1 0.04686GO:0050855regulation of B cell receptor signaling pathway 0.01536 1 0.04686GO:0042362fat-soluble vitamin biosynthetic process 0.01536 1 0.04686GO:0072677eosinophil migration 0.01536 1 0.04686GO:0051247positive regulation of protein metabolic process 0.01587 1 0.0483GO:0071605monocyte chemotactic protein-1 production 0.01631 1 0.04894GO:0032310prostaglandin secretion 0.01631 1 0.04894GO:0070254mucus secretion 0.01631 1 0.04894GO:0030889negative regulation of B cell proliferation 0.01631 1 0.04894GO:0045953negative regulation of natural killer cell mediated cytotoxicity0.01631 1 0.04894GO:0071637regulation of monocyte chemotactic protein-1 production0.01631 1 0.04894GO:0032516positive regulation of phosphoprotein phosphatase activity0.01631 1 0.04894GO:0017157regulation of exocytosis 0.01643 1 0.04919GO:0071396cellular response to lipid 0.01668 1 0.04983GO:1903531negative regulation of secretion by cell 0.01673 1 0.04989

Cluster 2 ID Name p-value q-value Bonferroniq-value FDR B&HRGS1 GO:0045321leukocyte activation 6.22E-13 5.5E-10 5.5E-10CD69 GO:0001775cell activation 8.1E-12 7.16E-09 3.58E-09GPR183 GO:0070489T cell aggregation 7.22E-10 6.38E-07 1.24E-07CD3G GO:0042110T cell activation 7.22E-10 6.38E-07 1.24E-07GZMK GO:0071593lymphocyte aggregation 7.35E-10 6.5E-07 1.24E-07IL2RA GO:0070486leukocyte aggregation 8.4E-10 7.42E-07 1.24E-07AMICA1 GO:0046649lymphocyte activation 1.03E-09 9.14E-07 1.31E-07FYB GO:0007159leukocyte cell-cell adhesion 1.56E-09 1.38E-06 1.72E-07PIK3CG GO:0006955immune response 3.84E-08 3.4E-05 3.77E-06DOCK2 GO:0002274myeloid leukocyte activation 1.62E-07 0.000143 1.43E-05DOCK8 GO:0098609cell-cell adhesion 3.82E-07 0.000338 3.07E-05SNX10 GO:0043087regulation of GTPase activity 2.88E-06 0.002548 0.000199ST8SIA4 GO:0046651lymphocyte proliferation 2.97E-06 0.002629 0.000199IQGAP2 GO:0032943mononuclear cell proliferation 3.15E-06 0.002784 0.000199APBB1IP GO:0070661leukocyte proliferation 4.23E-06 0.00374 0.000249ARHGAP25GO:0002521leukocyte differentiation 6.12E-06 0.005412 0.000338CASP1 GO:0030098lymphocyte differentiation 7.8E-06 0.006891 0.000405NPL GO:0042098T cell proliferation 1.06E-05 0.009342 0.000519MOP−1 GO:0002252immune effector process 1.38E-05 0.01218 0.000641CLEC7A GO:0002366leukocyte activation involved in immune response 1.62E-05 0.01436 0.000712TLR8 GO:0002263cell activation involved in immune response 1.69E-05 0.01496 0.000712P2RY13 GO:0038110interleukin-2-mediated signaling pathway 1.87E-05 0.01653 0.000722C14orf106 GO:0043547positive regulation of GTPase activity 1.88E-05 0.0166 0.000722MS4A14 GO:0030217T cell differentiation 1.99E-05 0.01755 0.000731CD3E GO:0007155cell adhesion 2.12E-05 0.01875 0.00075IL2RG GO:0022610biological adhesion 2.27E-05 0.02008 0.000772KCNA3 GO:0051345positive regulation of hydrolase activity 2.6E-05 0.02299 0.000852KLRG1 GO:0071352cellular response to interleukin-2 2.8E-05 0.02477 0.000885RHOH GO:0002684positive regulation of immune system process 3.71E-05 0.03277 0.00113TMEM154 GO:0051251positive regulation of lymphocyte activation 6.2E-05 0.05482 0.001827

GO:0051336regulation of hydrolase activity 6.41E-05 0.05666 0.001828GO:0070669response to interleukin-2 6.71E-05 0.05929 0.001853GO:0002696positive regulation of leukocyte activation 9.58E-05 0.0847 0.002567GO:0050867positive regulation of cell activation 0.000114 0.101 0.00297GO:0045576mast cell activation 0.000119 0.1053 0.003007

GO:0030097hemopoiesis 0.000124 0.11 0.003036GO:0002682regulation of immune system process 0.000127 0.1123 0.003036GO:0045060negative thymic T cell selection 0.000169 0.1492 0.003731GO:0001771immunological synapse formation 0.000169 0.1492 0.003731GO:0002664regulation of T cell tolerance induction 0.000169 0.1492 0.003731GO:0048534hematopoietic or lymphoid organ development 0.000174 0.1537 0.003748GO:0043085positive regulation of catalytic activity 0.000191 0.1687 0.00391GO:0043383negative T cell selection 0.000195 0.172 0.00391GO:0002517T cell tolerance induction 0.000195 0.172 0.00391GO:0034109homotypic cell-cell adhesion 0.000207 0.1829 0.004063GO:0070227lymphocyte apoptotic process 0.000229 0.2024 0.004363GO:0071594thymocyte aggregation 0.000237 0.2094 0.004363GO:0033077T cell differentiation in thymus 0.000237 0.2094 0.004363GO:0002520immune system development 0.000245 0.2161 0.004411GO:0045785positive regulation of cell adhesion 0.000268 0.2366 0.004732GO:0050870positive regulation of T cell activation 0.000278 0.246 0.004823GO:0034112positive regulation of homotypic cell-cell adhesion0.000302 0.2668 0.005132GO:1903039positive regulation of leukocyte cell-cell adhesion 0.000322 0.2844 0.005367GO:0051249regulation of lymphocyte activation 0.000331 0.2925 0.005417GO:0030155regulation of cell adhesion 0.000344 0.3041 0.005528GO:0006954inflammatory response 0.000363 0.3206 0.005725GO:0002643regulation of tolerance induction 0.000387 0.3423 0.005902GO:0001774microglial cell activation 0.000387 0.3423 0.005902GO:0002757immune response-activating signal transduction 0.000413 0.365 0.006187GO:0022409positive regulation of cell-cell adhesion 0.000546 0.4824 0.007989GO:0045061thymic T cell selection 0.000551 0.4873 0.007989GO:0002764immune response-regulating signaling pathway 0.000574 0.5076 0.008187GO:0071887leukocyte apoptotic process 0.000609 0.5382 0.008521GO:0002694regulation of leukocyte activation 0.000617 0.5453 0.008521GO:0036336dendritic cell migration 0.000644 0.5692 0.008757GO:0002253activation of immune response 0.000703 0.6218 0.00939GO:0044093positive regulation of molecular function 0.000712 0.6291 0.00939GO:0031347regulation of defense response 0.000773 0.6829 0.01004GO:0002507tolerance induction 0.000796 0.7036 0.0102GO:0050865regulation of cell activation 0.000868 0.767 0.0109GO:0046631alpha-beta T cell activation 0.000876 0.7742 0.0109GO:0050671positive regulation of lymphocyte proliferation 0.000972 0.8595 0.01194GO:0032946positive regulation of mononuclear cell proliferation0.001013 0.8952 0.01226GO:0050863regulation of T cell activation 0.001028 0.9088 0.01228GO:0002429immune response-activating cell surface receptor signaling pathway0.001088 0.9614 0.01282GO:0070665positive regulation of leukocyte proliferation 0.00114 1 0.01326GO:0007264small GTPase mediated signal transduction 0.00117 1 0.01343GO:1903037regulation of leukocyte cell-cell adhesion 0.001201 1 0.01361GO:0050776regulation of immune response 0.001247 1 0.01396GO:0046633alpha-beta T cell proliferation 0.001278 1 0.01412GO:0034110regulation of homotypic cell-cell adhesion 0.001294 1 0.01412GO:0061485memory T cell proliferation 0.001398 1 0.01489GO:0034158toll-like receptor 8 signaling pathway 0.001398 1 0.01489GO:0008037cell recognition 0.00145 1 0.01526GO:0002768immune response-regulating cell surface receptor signaling pathway0.001558 1 0.0162GO:0034260negative regulation of GTPase activity 0.00171 1 0.01758GO:0050852T cell receptor signaling pathway 0.001809 1 0.01838GO:0006897endocytosis 0.002016 1 0.02025GO:0050778positive regulation of immune response 0.002097 1 0.02079GO:0045058T cell selection 0.002117 1 0.02079GO:0038111interleukin-7-mediated signaling pathway 0.00279 1 0.02634GO:0098760response to interleukin-7 0.00279 1 0.02634GO:0098761cellular response to interleukin-7 0.00279 1 0.02634

GO:0022407regulation of cell-cell adhesion 0.002801 1 0.02634GO:0070231T cell apoptotic process 0.003156 1 0.02937GO:0042116macrophage activation 0.003474 1 0.03161GO:0046635positive regulation of alpha-beta T cell activation 0.003474 1 0.03161GO:0050670regulation of lymphocyte proliferation 0.003504 1 0.03161GO:0032944regulation of mononuclear cell proliferation 0.003594 1 0.03209GO:0009988cell-cell recognition 0.003919 1 0.03465GO:0042108positive regulation of cytokine biosynthetic process0.004035 1 0.03488GO:0070663regulation of leukocyte proliferation 0.004064 1 0.03488GO:0050851antigen receptor-mediated signaling pathway 0.004064 1 0.03488GO:0050717positive regulation of interleukin-1 alpha secretion0.004183 1 0.03488GO:0071226cellular response to molecule of fungal origin 0.004183 1 0.03488GO:0046013regulation of T cell homeostatic proliferation 0.004183 1 0.03488GO:0070228regulation of lymphocyte apoptotic process 0.00427 1 0.03528GO:0032729positive regulation of interferon-gamma production0.004886 1 0.03999GO:0006909phagocytosis 0.005227 1 0.04038GO:0002275myeloid cell activation involved in immune response0.00554 1 0.04038GO:0019262N-acetylneuraminate catabolic process 0.005573 1 0.04038GO:0035022positive regulation of Rac protein signal transduction0.005573 1 0.04038GO:0001766membrane raft polarization 0.005573 1 0.04038GO:0032831positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation0.005573 1 0.04038GO:0010897negative regulation of triglyceride catabolic process0.005573 1 0.04038GO:0045356positive regulation of interferon-alpha biosynthetic process0.005573 1 0.04038GO:0002669positive regulation of T cell anergy 0.005573 1 0.04038GO:0031580membrane raft distribution 0.005573 1 0.04038GO:0002913positive regulation of lymphocyte anergy 0.005573 1 0.04038GO:0002277myeloid dendritic cell activation involved in immune response0.005573 1 0.04038GO:0055118negative regulation of cardiac muscle contraction 0.005573 1 0.04038GO:0001777T cell homeostatic proliferation 0.005573 1 0.04038GO:0031295T cell costimulation 0.005812 1 0.04177GO:0031294lymphocyte costimulation 0.00595 1 0.04208GO:0071260cellular response to mechanical stimulus 0.00595 1 0.04208GO:0007249I-kappaB kinase/NF-kappaB signaling 0.006186 1 0.04312GO:0006952defense response 0.006195 1 0.04312GO:0046634regulation of alpha-beta T cell activation 0.006375 1 0.04402GO:0045582positive regulation of T cell differentiation 0.006519 1 0.04467GO:0050705regulation of interleukin-1 alpha secretion 0.006962 1 0.04593GO:0032252secretory granule localization 0.006962 1 0.04593GO:0035771interleukin-4-mediated signaling pathway 0.006962 1 0.04593GO:0051665membrane raft localization 0.006962 1 0.04593GO:0032829regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation0.006962 1 0.04593GO:0050871positive regulation of B cell activation 0.007417 1 0.04857GO:0007186G protein-coupled receptor signaling pathway 0.007672 1 0.04987

Cluster 3 ID Name p-value q-value Bonferroniq-value FDR B&HCCDC80 GO:0030334regulation of cell migration 3.36E-06 0.003581 0.00139HLA-DPB1GO:0007155cell adhesion 4.09E-06 0.004363 0.00139LAPTM5 GO:0022610biological adhesion 4.36E-06 0.004655 0.00139CD74 GO:2000145regulation of cell motility 5.21E-06 0.005561 0.00139COL1A1 GO:0006952defense response 7.68E-06 0.008193 0.001418PCOLCE GO:0051270regulation of cellular component movement 8.89E-06 0.009486 0.001418TGFBI GO:0040012regulation of locomotion 9.31E-06 0.009928 0.001418F2R GO:0001568blood vessel development 2.31E-05 0.02465 0.002273DOCK10 GO:0001775cell activation 2.39E-05 0.02554 0.002273GOLGA8BGO:0051674localization of cell 2.55E-05 0.02723 0.002273LOC100510059GO:0048870cell motility 2.55E-05 0.02723 0.002273CD53 GO:0050900leukocyte migration 2.56E-05 0.02728 0.002273LYZ GO:0001944vasculature development 2.88E-05 0.03075 0.002365CX3CR1 GO:0030595leukocyte chemotaxis 3.51E-05 0.03746 0.002572

CXCR4 GO:0006954inflammatory response 3.8E-05 0.04051 0.002572CD163 GO:0071345cellular response to cytokine stimulus 3.86E-05 0.04116 0.002572C3AR1 GO:0001525angiogenesis 6.16E-05 0.06568 0.003863SLCO2B1 GO:0034097response to cytokine 8.71E-05 0.09295 0.005072FCGR3A GO:0060326cell chemotaxis 9.03E-05 0.09638 0.005072IFI30 GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II9.62E-05 0.1026 0.005132

GO:0040011locomotion 0.000104 0.1109 0.005282GO:0002495antigen processing and presentation of peptide antigen via MHC class II0.000112 0.1197 0.005363GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II0.000116 0.1234 0.005363GO:0048646anatomical structure formation involved in morphogenesis0.000127 0.1354 0.005442GO:0016477cell migration 0.000128 0.136 0.005442GO:0048514blood vessel morphogenesis 0.000139 0.1478 0.005569GO:0019221cytokine-mediated signaling pathway 0.000141 0.1504 0.005569GO:0046651lymphocyte proliferation 0.000171 0.1826 0.006522GO:0032943mononuclear cell proliferation 0.000178 0.1897 0.006542GO:0006928movement of cell or subcellular component 0.000185 0.1973 0.006578GO:0070661leukocyte proliferation 0.000216 0.2309 0.007448GO:0098609cell-cell adhesion 0.000225 0.2398 0.007492GO:0090023positive regulation of neutrophil chemotaxis 0.000283 0.3018 0.009146GO:0072358cardiovascular system development 0.000341 0.3634 0.01038GO:0072359circulatory system development 0.000341 0.3634 0.01038GO:0071624positive regulation of granulocyte chemotaxis 0.000353 0.3764 0.01045GO:0090022regulation of neutrophil chemotaxis 0.000404 0.4306 0.01154GO:0006955immune response 0.000417 0.4444 0.01154GO:1902624positive regulation of neutrophil migration 0.00043 0.459 0.01154GO:0030155regulation of cell adhesion 0.000433 0.4616 0.01154GO:0051240positive regulation of multicellular organismal process0.000482 0.5146 0.01235GO:0048246macrophage chemotaxis 0.000486 0.5186 0.01235GO:0002478antigen processing and presentation of exogenous peptide antigen0.000514 0.5488 0.01276GO:0019884antigen processing and presentation of exogenous antigen0.00058 0.619 0.01383GO:0097529myeloid leukocyte migration 0.00059 0.6295 0.01383GO:0001819positive regulation of cytokine production 0.000596 0.6363 0.01383GO:1902622regulation of neutrophil migration 0.00064 0.683 0.01453GO:0048002antigen processing and presentation of peptide antigen0.000705 0.7524 0.01567GO:0030335positive regulation of cell migration 0.000754 0.8048 0.01642GO:2000147positive regulation of cell motility 0.00084 0.8963 0.0171GO:0071622regulation of granulocyte chemotaxis 0.000852 0.9094 0.0171GO:0050920regulation of chemotaxis 0.000871 0.9296 0.0171GO:0032964collagen biosynthetic process 0.000891 0.9502 0.0171GO:0045321leukocyte activation 0.000906 0.967 0.0171GO:0051272positive regulation of cellular component movement0.000925 0.9871 0.0171GO:0071718sodium-independent icosanoid transport 0.000967 1 0.0171GO:0002881negative regulation of chronic inflammatory response to non-antigenic stimulus0.000967 1 0.0171GO:1900134negative regulation of renin secretion into blood stream0.000967 1 0.0171GO:0002462tolerance induction to nonself antigen 0.000967 1 0.0171GO:1902618cellular response to fluoride 0.000967 1 0.0171GO:0040017positive regulation of locomotion 0.000978 1 0.0171GO:0051931regulation of sensory perception 0.00101 1 0.01711GO:0051930regulation of sensory perception of pain 0.00101 1 0.01711GO:0042098T cell proliferation 0.001089 1 0.01816GO:0051094positive regulation of developmental process 0.001121 1 0.0184GO:0070489T cell aggregation 0.001217 1 0.01924GO:0042110T cell activation 0.001217 1 0.01924GO:0071593lymphocyte aggregation 0.001226 1 0.01924GO:0070486leukocyte aggregation 0.00129 1 0.01995GO:0050776regulation of immune response 0.001312 1 0.02GO:0019882antigen processing and presentation 0.001356 1 0.02038GO:0008284positive regulation of cell proliferation 0.001483 1 0.02198

GO:0007159leukocyte cell-cell adhesion 0.001634 1 0.02359GO:0090280positive regulation of calcium ion import 0.001664 1 0.02359GO:0042116macrophage activation 0.001664 1 0.02359GO:0007162negative regulation of cell adhesion 0.00168 1 0.02359GO:0045597positive regulation of cell differentiation 0.001807 1 0.02455GO:0002880regulation of chronic inflammatory response to non-antigenic stimulus0.001932 1 0.02455GO:1900272negative regulation of long-term synaptic potentiation0.001932 1 0.02455GO:0035691macrophage migration inhibitory factor signaling pathway0.001932 1 0.02455GO:0002545chronic inflammatory response to non-antigenic stimulus0.001932 1 0.02455GO:0022029telencephalon cell migration 0.001935 1 0.02455GO:0006935chemotaxis 0.001949 1 0.02455GO:0042330taxis 0.001974 1 0.02455GO:0043207response to external biotic stimulus 0.001979 1 0.02455GO:0051707response to other organism 0.001979 1 0.02455GO:0061448connective tissue development 0.002006 1 0.0246GO:0021885forebrain cell migration 0.002108 1 0.02556GO:0009617response to bacterium 0.002141 1 0.02567GO:0032101regulation of response to external stimulus 0.002239 1 0.02654GO:0007204positive regulation of cytosolic calcium ion concentration0.002321 1 0.02722GO:0009607response to biotic stimulus 0.002368 1 0.02746GO:0070098chemokine-mediated signaling pathway 0.002667 1 0.03059GO:0001817regulation of cytokine production 0.002734 1 0.03104GO:0071306cellular response to vitamin E 0.002897 1 0.03122GO:0044691tooth eruption 0.002897 1 0.03122GO:0002282microglial cell activation involved in immune response0.002897 1 0.03122GO:0007529establishment of synaptic specificity at neuromuscular junction0.002897 1 0.03122GO:0002461tolerance induction dependent upon immune response0.002897 1 0.03122GO:0051480regulation of cytosolic calcium ion concentration 0.002985 1 0.03173GO:0060333interferon-gamma-mediated signaling pathway 0.003004 1 0.03173GO:0031644regulation of neurological system process 0.003074 1 0.03184GO:0002690positive regulation of leukocyte chemotaxis 0.003074 1 0.03184GO:0032147activation of protein kinase activity 0.003269 1 0.03353GO:0050778positive regulation of immune response 0.003414 1 0.03469GO:0030593neutrophil chemotaxis 0.003508 1 0.03531GO:0042127regulation of cell proliferation 0.00367 1 0.0366GO:0002429immune response-activating cell surface receptor signaling pathway0.003756 1 0.03711GO:1902617response to fluoride 0.003861 1 0.03779GO:0001816cytokine production 0.003974 1 0.03855GO:0032496response to lipopolysaccharide 0.004082 1 0.03924GO:0046649lymphocyte activation 0.00416 1 0.03964GO:0048145regulation of fibroblast proliferation 0.004211 1 0.03976GO:1990266neutrophil migration 0.004375 1 0.04095GO:0048144fibroblast proliferation 0.004458 1 0.04118GO:0030198extracellular matrix organization 0.004496 1 0.04118GO:0043062extracellular structure organization 0.004531 1 0.04118GO:0043405regulation of MAP kinase activity 0.004567 1 0.04118GO:0002237response to molecule of bacterial origin 0.004639 1 0.04118GO:0002688regulation of leukocyte chemotaxis 0.004712 1 0.04118GO:0002906negative regulation of mature B cell apoptotic process0.004824 1 0.04118GO:0002905regulation of mature B cell apoptotic process 0.004824 1 0.04118GO:0002430complement receptor mediated signaling pathway 0.004824 1 0.04118GO:1900133regulation of renin secretion into blood stream 0.004824 1 0.04118GO:0002901mature B cell apoptotic process 0.004824 1 0.04118GO:0002768immune response-regulating cell surface receptor signaling pathway0.004934 1 0.04178GO:0071621granulocyte chemotaxis 0.004973 1 0.04178GO:0097709connective tissue replacement 0.005786 1 0.04573GO:0035701hematopoietic stem cell migration 0.005786 1 0.04573GO:0072126positive regulation of glomerular mesangial cell proliferation0.005786 1 0.04573

GO:0001957intramembranous ossification 0.005786 1 0.04573GO:0002248connective tissue replacement involved in inflammatory response wound healing0.005786 1 0.04573GO:0002677negative regulation of chronic inflammatory response0.005786 1 0.04573GO:0036072direct ossification 0.005786 1 0.04573GO:0003105negative regulation of glomerular filtration 0.005786 1 0.04573GO:0090279regulation of calcium ion import 0.005984 1 0.04695GO:0051928positive regulation of calcium ion transport 0.006081 1 0.04702GO:0032963collagen metabolic process 0.006081 1 0.04702GO:0097530granulocyte migration 0.006178 1 0.04742GO:0044800multi-organism membrane fusion 0.006747 1 0.0494GO:0039663membrane fusion involved in viral entry into host cell0.006747 1 0.0494GO:0002606positive regulation of dendritic cell antigen processing and presentation0.006747 1 0.0494GO:0002001renin secretion into blood stream 0.006747 1 0.0494GO:0019064fusion of virus membrane with host plasma membrane0.006747 1 0.0494GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production0.006747 1 0.0494GO:0002687positive regulation of leukocyte migration 0.006774 1 0.0494GO:0006874cellular calcium ion homeostasis 0.006805 1 0.0494GO:0050921positive regulation of chemotaxis 0.006876 1 0.04958

Cluster 4 ID Name p-value q-value Bonferroniq-value FDR B&HCARTPT GO:0045785positive regulation of cell adhesion 2.01E-06 0.002654 0.002654PLEK GO:0022409positive regulation of cell-cell adhesion 5.04E-06 0.006674 0.003199EVI2B GO:0030097hemopoiesis 8.3E-06 0.01098 0.003199PTPRC GO:0048534hematopoietic or lymphoid organ development 1.18E-05 0.01561 0.003199AOAH GO:0045588positive regulation of gamma-delta T cell differentiation1.32E-05 0.01747 0.003199ADAM28 GO:0033627cell adhesion mediated by integrin 1.63E-05 0.02152 0.003199ITGA4 GO:0002520immune system development 1.69E-05 0.02239 0.003199TM6SF1 GO:0046645positive regulation of gamma-delta T cell activation2.46E-05 0.03257 0.004072ALOX5 GO:0045586regulation of gamma-delta T cell differentiation 3.16E-05 0.04186 0.004227FAM49B GO:0030155regulation of cell adhesion 3.59E-05 0.04752 0.004227PLXNC1 GO:0007155cell adhesion 4.21E-05 0.05575 0.004227ARL4C GO:0022407regulation of cell-cell adhesion 4.29E-05 0.05669 0.004227CD4 GO:0022610biological adhesion 4.46E-05 0.05899 0.004227HLA−DMBGO:0046643regulation of gamma-delta T cell activation 4.83E-05 0.06387 0.004227IL10RA GO:0045937positive regulation of phosphate metabolic process5.11E-05 0.06763 0.004227NCKAP1L GO:0010562positive regulation of phosphorus metabolic process5.11E-05 0.06763 0.004227SFRP2 GO:0042492gamma-delta T cell differentiation 5.79E-05 0.07661 0.004506GPR116 GO:1903039positive regulation of leukocyte cell-cell adhesion 7.14E-05 0.09448 0.005249GNG2 GO:0007229integrin-mediated signaling pathway 9.93E-05 0.1313 0.006912ITGA6 GO:0002521leukocyte differentiation 0.000118 0.1554 0.007772

GO:0046629gamma-delta T cell activation 0.000134 0.177 0.008044GO:0033630positive regulation of cell adhesion mediated by integrin0.000134 0.177 0.008044GO:0042102positive regulation of T cell proliferation 0.000141 0.187 0.008129GO:0098609cell-cell adhesion 0.000225 0.2973 0.01205GO:0009991response to extracellular stimulus 0.000244 0.3229 0.01205GO:0030183B cell differentiation 0.000246 0.3249 0.01205GO:0001775cell activation 0.000252 0.3337 0.01205GO:0042327positive regulation of phosphorylation 0.000255 0.3373 0.01205GO:0032101regulation of response to external stimulus 0.000271 0.3579 0.01216GO:1903037regulation of leukocyte cell-cell adhesion 0.000276 0.3649 0.01216GO:0050867positive regulation of cell activation 0.000318 0.4208 0.01294GO:0050671positive regulation of lymphocyte proliferation 0.000319 0.422 0.01294GO:0030098lymphocyte differentiation 0.000325 0.4299 0.01294GO:0032946positive regulation of mononuclear cell proliferation0.000332 0.4398 0.01294GO:0070665positive regulation of leukocyte proliferation 0.000375 0.4961 0.01388GO:0045577regulation of B cell differentiation 0.000378 0.4997 0.01388GO:0043085positive regulation of catalytic activity 0.000443 0.5865 0.01585GO:0030866cortical actin cytoskeleton organization 0.000458 0.6055 0.01593GO:0051240positive regulation of multicellular organismal process0.000482 0.6381 0.01636

GO:0034109homotypic cell-cell adhesion 0.000515 0.6811 0.01703GO:0030334regulation of cell migration 0.000551 0.7283 0.01776GO:0042129regulation of T cell proliferation 0.00058 0.7676 0.01785GO:2001236regulation of extrinsic apoptotic signaling pathway 0.00058 0.7676 0.01785GO:0030890positive regulation of B cell proliferation 0.00064 0.8469 0.01896GO:0045859regulation of protein kinase activity 0.000671 0.8882 0.01896GO:0030865cortical cytoskeleton organization 0.000673 0.8909 0.01896GO:0033628regulation of cell adhesion mediated by integrin 0.000673 0.8909 0.01896GO:2000145regulation of cell motility 0.000745 0.9859 0.0202GO:0040011locomotion 0.00076 1 0.0202GO:0031401positive regulation of protein modification process0.000763 1 0.0202GO:0019220regulation of phosphate metabolic process 0.000818 1 0.02046GO:0051174regulation of phosphorus metabolic process 0.000855 1 0.02046GO:1990771clathrin-dependent extracellular exosome endocytosis0.000967 1 0.02046GO:0010924regulation of inositol-polyphosphate 5-phosphatase activity0.000967 1 0.02046GO:0032812positive regulation of epinephrine secretion 0.000967 1 0.02046GO:0006948induction by virus of host cell-cell fusion 0.000967 1 0.02046GO:0061185negative regulation of dermatome development 0.000967 1 0.02046GO:0030845phospholipase C-inhibiting G protein-coupled receptor signaling pathway0.000967 1 0.02046GO:0043378positive regulation of CD8-positive, alpha-beta T cell differentiation0.000967 1 0.02046GO:0010925positive regulation of inositol-polyphosphate 5-phosphatase activity0.000967 1 0.02046GO:0060305regulation of cell diameter 0.000967 1 0.02046GO:0034113heterotypic cell-cell adhesion 0.000969 1 0.02046GO:0043549regulation of kinase activity 0.000978 1 0.02046GO:0007584response to nutrient 0.001004 1 0.02046GO:0045058T cell selection 0.00101 1 0.02046GO:0016477cell migration 0.001022 1 0.02046GO:0031668cellular response to extracellular stimulus 0.001046 1 0.02046GO:0050732negative regulation of peptidyl-tyrosine phosphorylation0.001052 1 0.02046GO:0051270regulation of cellular component movement 0.001075 1 0.02059GO:0042098T cell proliferation 0.001089 1 0.02059GO:0040012regulation of locomotion 0.001109 1 0.02067GO:0045860positive regulation of protein kinase activity 0.00113 1 0.02077GO:0050670regulation of lymphocyte proliferation 0.001179 1 0.02137GO:0032944regulation of mononuclear cell proliferation 0.00121 1 0.02164GO:0044093positive regulation of molecular function 0.001283 1 0.02264GO:0050870positive regulation of T cell activation 0.001339 1 0.02329GO:0070663regulation of leukocyte proliferation 0.001373 1 0.02329GO:0050851antigen receptor-mediated signaling pathway 0.001373 1 0.02329GO:0034112positive regulation of homotypic cell-cell adhesion0.001424 1 0.02385GO:0033674positive regulation of kinase activity 0.001444 1 0.02387GO:0030888regulation of B cell proliferation 0.001461 1 0.02387GO:0050730regulation of peptidyl-tyrosine phosphorylation 0.001495 1 0.02412GO:0030217T cell differentiation 0.001586 1 0.02454GO:0090066regulation of anatomical structure size 0.00159 1 0.02454GO:0097191extrinsic apoptotic signaling pathway 0.001623 1 0.02454GO:0007159leukocyte cell-cell adhesion 0.001634 1 0.02454GO:0050865regulation of cell activation 0.001656 1 0.02454GO:0046635positive regulation of alpha-beta T cell activation 0.001664 1 0.02454GO:0051674localization of cell 0.00167 1 0.02454GO:0048870cell motility 0.00167 1 0.02454GO:0001934positive regulation of protein phosphorylation 0.00175 1 0.02544GO:0050853B cell receptor signaling pathway 0.00177 1 0.02546GO:0042113B cell activation 0.001818 1 0.02556GO:0035397helper T cell enhancement of adaptive immune response0.001932 1 0.02556GO:0070560protein secretion by platelet 0.001932 1 0.02556GO:0003366cell-matrix adhesion involved in ameboidal cell migration0.001932 1 0.02556GO:0043376regulation of CD8-positive, alpha-beta T cell differentiation0.001932 1 0.02556

GO:0010920negative regulation of inositol phosphate biosynthetic process0.001932 1 0.02556GO:2000471regulation of hematopoietic stem cell migration 0.001932 1 0.02556GO:2000473positive regulation of hematopoietic stem cell migration0.001932 1 0.02556GO:0051338regulation of transferase activity 0.002162 1 0.02798GO:0031667response to nutrient levels 0.002168 1 0.02798GO:1902105regulation of leukocyte differentiation 0.002205 1 0.02798GO:0042325regulation of phosphorylation 0.002227 1 0.02798GO:0032270positive regulation of cellular protein metabolic process0.002242 1 0.02798GO:0045936negative regulation of phosphate metabolic process0.002263 1 0.02798GO:0010563negative regulation of phosphorus metabolic process0.002263 1 0.02798GO:0048585negative regulation of response to stimulus 0.002288 1 0.02803GO:0071496cellular response to external stimulus 0.002564 1 0.03112GO:0046651lymphocyte proliferation 0.002849 1 0.03276GO:0002540leukotriene production involved in inflammatory response0.002897 1 0.03276GO:2000041negative regulation of planar cell polarity pathway involved in axis elongation0.002897 1 0.03276GO:0002378immunoglobulin biosynthetic process 0.002897 1 0.03276GO:0070358actin polymerization-dependent cell motility 0.002897 1 0.03276GO:2000040regulation of planar cell polarity pathway involved in axis elongation0.002897 1 0.03276GO:1904956regulation of midbrain dopaminergic neuron differentiation0.002897 1 0.03276GO:0008653lipopolysaccharide metabolic process 0.002897 1 0.03276GO:0032943mononuclear cell proliferation 0.00293 1 0.03285GO:0050848regulation of calcium-mediated signaling 0.003004 1 0.03312GO:0002824positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.003004 1 0.03312GO:0046634regulation of alpha-beta T cell activation 0.003074 1 0.03355GO:0051247positive regulation of protein metabolic process 0.003098 1 0.03355GO:0051251positive regulation of lymphocyte activation 0.003125 1 0.03355GO:0045582positive regulation of T cell differentiation 0.003144 1 0.03355GO:0032147activation of protein kinase activity 0.003269 1 0.0346GO:0051347positive regulation of transferase activity 0.003305 1 0.03471GO:0070661leukocyte proliferation 0.003387 1 0.03528GO:0002821positive regulation of adaptive immune response 0.003508 1 0.03626GO:0042100B cell proliferation 0.003583 1 0.03635GO:0050871positive regulation of B cell activation 0.003583 1 0.03635GO:0050863regulation of T cell activation 0.003599 1 0.03635GO:0002429immune response-activating cell surface receptor signaling pathway0.003756 1 0.03649GO:1903238positive regulation of leukocyte tethering or rolling0.003861 1 0.03649GO:0002538arachidonic acid metabolite production involved in inflammatory response0.003861 1 0.03649GO:0042662negative regulation of mesodermal cell fate specification0.003861 1 0.03649GO:0006933negative regulation of cell adhesion involved in substrate-bound cell migration0.003861 1 0.03649GO:0061183regulation of dermatome development 0.003861 1 0.03649GO:0061054dermatome development 0.003861 1 0.03649GO:0050904diapedesis 0.003861 1 0.03649GO:0070093negative regulation of glucagon secretion 0.003861 1 0.03649GO:0002696positive regulation of leukocyte activation 0.004049 1 0.03799GO:0045621positive regulation of lymphocyte differentiation 0.00413 1 0.03822GO:0006470protein dephosphorylation 0.004149 1 0.03822GO:0046649lymphocyte activation 0.00416 1 0.03822GO:0034110regulation of homotypic cell-cell adhesion 0.004286 1 0.0391GO:0030198extracellular matrix organization 0.004496 1 0.04074GO:0043062extracellular structure organization 0.004531 1 0.04078GO:0043405regulation of MAP kinase activity 0.004567 1 0.04082GO:0001915negative regulation of T cell mediated cytotoxicity0.004824 1 0.04227GO:0061056sclerotome development 0.004824 1 0.04227GO:0090074negative regulation of protein homodimerization activity0.004824 1 0.04227GO:0002768immune response-regulating cell surface receptor signaling pathway0.004934 1 0.04294GO:1903706regulation of hemopoiesis 0.005086 1 0.04397GO:2001237negative regulation of extrinsic apoptotic signaling pathway0.00524 1 0.04502GO:0032535regulation of cellular component size 0.005358 1 0.04573

GO:0018108peptidyl-tyrosine phosphorylation 0.00568 1 0.04584GO:0050900leukocyte migration 0.005721 1 0.04584GO:0018212peptidyl-tyrosine modification 0.005762 1 0.04584GO:0033625positive regulation of integrin activation 0.005786 1 0.04584GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin0.005786 1 0.04584GO:0048539bone marrow development 0.005786 1 0.04584GO:0035701hematopoietic stem cell migration 0.005786 1 0.04584GO:0010572positive regulation of platelet activation 0.005786 1 0.04584GO:1904693midbrain morphogenesis 0.005786 1 0.04584GO:0035509negative regulation of myosin-light-chain-phosphatase activity0.005786 1 0.04584GO:2001300lipoxin metabolic process 0.005786 1 0.04584GO:1904996positive regulation of leukocyte adhesion to vascular endothelial cell0.005786 1 0.04584GO:0031399regulation of protein modification process 0.006036 1 0.04753GO:0001704formation of primary germ layer 0.006178 1 0.04836GO:2001233regulation of apoptotic signaling pathway 0.006714 1 0.04902GO:0006928movement of cell or subcellular component 0.006726 1 0.04902GO:0044800multi-organism membrane fusion 0.006747 1 0.04902GO:0003402planar cell polarity pathway involved in axis elongation0.006747 1 0.04902GO:0039663membrane fusion involved in viral entry into host cell0.006747 1 0.04902GO:1904338regulation of dopaminergic neuron differentiation 0.006747 1 0.04902GO:2000051negative regulation of non-canonical Wnt signaling pathway0.006747 1 0.04902GO:0019064fusion of virus membrane with host plasma membrane0.006747 1 0.04902GO:0048304positive regulation of isotype switching to IgG isotypes0.006747 1 0.04902GO:2000035regulation of stem cell division 0.006747 1 0.04902GO:0042661regulation of mesodermal cell fate specification 0.006747 1 0.04902GO:2001187positive regulation of CD8-positive, alpha-beta T cell activation0.006747 1 0.04902GO:0002687positive regulation of leukocyte migration 0.006774 1 0.04902GO:0023057negative regulation of signaling 0.006781 1 0.04902

Cluster 5 ID Name p-value q-value Bonferroniq-value FDR B&HOLR1 GO:0002322B cell proliferation involved in immune response 0.003486 0.5159 0.4597TMEM200AGO:0009312oligosaccharide biosynthetic process 0.00904 1 0.4597MPHOSPH9GO:0035589G protein-coupled purinergic nucleotide receptor signaling pathway0.009732 1 0.4597ZNF107 GO:0035590purinergic nucleotide receptor signaling pathway 0.01525 1 0.4597CRYGS GO:0035588G protein-coupled purinergic receptor signaling pathway0.01594 1 0.4597SNRPA1 GO:0035587purinergic receptor signaling pathway 0.02143 1 0.4597FP6628 GO:0010165response to X-ray 0.0228 1 0.4597RPS20P27 GO:0001782B cell homeostasis 0.02485 1 0.4597KIAA1147 GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response0.03638 1 0.5149B3GALT2 GO:0002312B cell activation involved in immune response 0.04445 1 0.5149IKBIP GO:0009311oligosaccharide metabolic process 0.04579 1 0.5149GPR34 GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic0.04646 1 0.5149RNASE2GAPTTMTC2

q-value FDR B&Y0.0008480.0008480.0009240.0009380.0009440.0015370.0018730.0018830.0019070.0020690.0021280.0023930.0043650.0049050.0056650.0056650.0077930.0083320.0091490.009149

0.00950.00950.00950.00950.00950.0095

0.0095880.0095880.0095880.009588

0.010160.010160.010160.010160.010160.010160.010160.010160.010160.010370.010410.011320.011320.011510.01210.0121

0.012820.015150.016760.016760.017390.017390.017390.017390.017390.01770.0177

0.01770.0177

0.017730.019260.021470.021470.023580.02358

0.0250.025330.025620.025650.026570.026570.027510.027510.027510.027510.027510.028140.028180.028520.029570.030620.030620.030620.031780.0337

0.033910.033910.033910.03520.0362

0.037040.040110.040160.040160.040510.040960.046350.046360.049130.049130.049150.0505

0.053070.053070.05520.0552

0.058520.061590.063310.066150.072150.074090.074090.074090.07409

0.074090.075550.075690.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.080950.086540.086540.09580.0958

0.096660.096660.096660.096690.096730.097170.097170.097540.098310.098440.098440.098440.10190.10420.10440.10640.11010.11280.1152

0.1160.11670.11670.11710.11950.11950.11950.11950.11950.11950.11950.11950.11950.1195

0.11950.11950.11950.11950.11950.11950.11950.11950.11950.11950.11950.12850.12910.12980.13020.13020.13180.13240.13240.1346

0.1440.144

0.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14750.14860.15160.16430.16650.16870.16930.17060.1706

0.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17060.17520.17750.1783

0.1810.1896

0.1990.199

0.19990.19990.19990.19990.19990.19990.19990.19990.19990.19990.2018

0.2030.20310.21860.21860.21860.21860.21860.21860.21860.21860.21860.21860.21860.2186

0.21860.21860.21860.21860.21860.21860.21860.21860.21860.21860.21860.21860.22150.22490.22490.22490.22490.22490.22490.22490.22490.22490.22490.22770.23310.23340.23580.23580.23580.23580.23580.23580.23580.23580.23580.2358

0.2360.246

0.25010.25090.25090.25480.25480.25480.25480.25480.25480.25480.25480.25480.25480.25480.25480.25480.25480.26040.26040.2633

0.26970.27260.27570.27570.27570.27570.27570.27570.27570.27570.28380.28580.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.28920.2892

0.2980.30280.30930.30980.30980.30980.30980.30980.30980.30980.32040.32040.32120.32120.32120.32120.32120.32120.32120.32120.32120.32120.32120.32120.32120.32120.3212

0.32120.32120.32120.32330.32620.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.32850.34040.34330.34330.34330.34330.34330.34330.34330.34330.34330.34330.34330.34330.34640.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.35340.3534

0.35530.3680.3680.3680.3680.3680.3680.3680.3680.3680.368

0.37940.38430.38430.38430.38430.38430.38430.38430.38630.39130.3919

q-value FDR B&Y4.05E-092.64E-089.11E-079.11E-079.11E-079.11E-079.61E-071.27E-062.78E-050.0001060.0002260.0014640.0014640.0014640.001836

0.002490.0029840.0038210.0047210.0052440.0052440.0053150.0053150.0053840.0055230.0056860.0062690.006512

0.008320.013450.013460.013640.0189

0.021870.02214

0.022360.022360.027470.027470.027470.0276

0.028790.028790.028790.029920.032120.032120.032120.032470.034840.035510.037780.039510.039880.0407

0.042150.043450.043450.045550.058820.058820.060270.062730.062730.064470.069130.069130.073940.075080.080280.080280.087880.090280.090420.094380.097640.09890.10020.10280.1039

0.1040.10960.10960.11240.11930.12940.13530.14910.15310.15310.19390.19390.1939

0.19390.21620.23270.23270.23270.23630.25510.25680.25680.25680.25680.25680.25680.25970.29440.29730.29730.29730.29730.29730.29730.29730.29730.29730.29730.29730.29730.29730.29730.30750.30980.30980.31740.31740.32410.32890.33810.33810.33810.33810.33810.35760.3671

q-value FDR B&Y0.01050.01050.01050.0105

0.010710.010710.010710.017160.017160.017160.017160.017160.017860.01942

0.019420.019420.029170.03830.0383

0.038750.039880.04050.0405

0.041090.041090.042050.042050.049250.049390.049660.056240.056570.069050.07840.0784

0.078940.087120.087120.087120.087120.093220.093220.096360.10440.10440.10440.10970.1183

0.1240.12910.12910.12910.12910.12910.12910.12910.12910.12910.12910.12910.12910.12920.12920.1371

0.1390.14520.14520.14520.1506

0.1510.15390.1659

0.17810.17810.17810.17810.18540.18540.18540.18540.18540.18540.18540.18540.18540.18540.1857

0.1930.19380.20040.20550.2073

0.2310.23430.23570.23570.23570.23570.23570.23960.23960.24040.24040.2532

0.2620.26660.27630.28020.28540.29110.29630.29930.30020.30920.31090.31090.31090.31090.31090.31090.31090.31090.31090.31090.31090.31540.31540.34530.34530.3453

0.34530.34530.34530.34530.34530.3545

0.3550.3550.3580.3730.3730.3730.3730.3730.3730.3730.373

0.3743q-value FDR B&Y

0.020610.024840.024840.024840.024840.024840.024840.031620.032820.032820.032820.032820.032820.032820.032820.032820.034990.040760.053670.060350.062470.062470.063120.093550.093550.093550.093550.093550.094460.094460.10040.10040.10040.10040.10780.10780.12310.1237

0.127

0.13220.13790.13860.13860.14720.14720.14720.14720.15680.15680.15680.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15890.15990.15990.16050.1613

0.1660.168

0.17580.18080.18080.18080.18520.18530.18530.18730.19060.19060.19060.19060.19060.19060.19060.19060.19750.19770.19850.19850.19850.19850.1985

0.19850.19850.19850.21730.21730.21730.21730.21730.21730.21730.21760.24170.25440.25440.25440.25440.25440.25440.25440.25440.25510.25720.25720.26050.26050.26050.26050.26860.26950.27390.28160.28230.28230.28230.28330.28330.28330.28330.28330.28330.28330.28330.2833

0.2950.29680.29680.29680.30360.31630.3167

0.3170.32820.32820.32820.33350.34150.34960.3551

0.35590.35590.35590.35590.35590.35590.35590.35590.35590.35590.35590.35590.36910.37550.38070.38070.38070.38070.38070.38070.38070.38070.38070.38070.38070.38070.38070.3807

q-value FDR B&Y111111111111