1

Effect of metastases on bone strength

Validation of microCT based microFE models of porcine vertebrae:

Collaboration with Dr Lazari, Dr Eltes, Centre Spine Disorders, Hungary

DVC microFE

P A

Effect of the size and location of virtually induced lytic lesions on the local and structural properties of human vertebrae – parametric microFE models

Transverse mid cross-section

Centre points of the lesions

2

Effect of metastases on bone strength

Biomechanical analyzes of patients with vertebral lytic lesions using subject specific QCT-based homogenized FE models:

Collaboration with Dr Lazari, Dr Eltes, Centre Spine Disorders, Hungary

L1

L1

T12T12

Levels Condition SINSscore

%diff E [MPa]

%diff σU[MPa]

SFAvg

%diffSF

T11+L2 Controls8 -27% -27%

1.3-24%

T12 Lytic 1.0

T11+L2 Controls11 28% 24%

1.342%

L1 Lytic 1.8