Collagen Disorders and Homoeopathy

8/18/2019 Collagen Disorders and Homoeopathy

1/19


2/19

COLLAGEN DISORDERS AND HOMOEOPATHY

COLLAGEN DISORDERS AND

HOMOEOPATHY © Dr. Rajneesh Kumar Sharma MD (Homoeopathy)

Dr. Swat !shn" BHMSDr. Preet#a La#hera BHMSHomoeo Cure Research InstituteNH 74- Moradabad Roadashipur (!""#R#NCH#$) - INDI#%h- &''7*+'4, mai.- drra/neeshhom0hotmai.com1 222treatmenthomeopathycom1222homeopathy2or.dcommunitycom

C3N",N"S

Introduction

,tymo.o5y

De6nition

#natomy

%rimary structure

Sec1 "ertiary 8uaternary Structure

Co..a5en crimpin54

Synthesis o9 co..a5en+

In Nuc.eus+

In Cytop.asm+

,:trace..u.ar+

Re5u.ation o9 Synthesis+

Se;uence o9 intrace..u.ar co..a5en biosynthesis+

Se;uence o9 e:trace..u.ar co..a5en biosynthesis+

unctions

*© Dr. Rajneesh Kumar Sharma MD (Homoeoa!h"#

mailto:[email protected]://www.homeopathyworldcommunity.com/http://www.homeopathyworldcommunity.com/mailto:[email protected]


3/19


Co..a5en disorders'

Hi5h su5ar consumption'

Smo?in5'

Sun.i5ht'

#utoimmune disorders'

#5in5'

$upus ,rythematosus'

Sc.eroderma'

%o.yarteritis nodosa*&

,pidermo.ysis bu..osa*&

Rheumatoid arthritis*&

Crohn@s disease**

Ae5,ner@s 5ranu.omatosis**Chur5-Strauss syndrome**

Microscopic po.yan5iitis**

%o.ymyositisdermatomyositis**

3steo5enesis imper9ecta*

Chondrodysp.asias*

,h.er-Dan.os Syndrome*

#.port syndrome*

3steoporosis*nob.och syndrome*

Scur=y*

"reatment *

Medica. uses o9 co..a5en*

S?in 6..ers*

Aound dressin5*


4/19


IN"R3D!C"I3N

• Co..a5en is a 9ami.y o9 hi5h.y de=e.oped 6brous proteins 9ound in a.. mu.tice..u.aranima.s

• & percent o9 the bodyFs mass is made up o9 proteins1 out o9 2hich1 & percent is

co..a5en protein• "here are more than * types o9 co..a5en1 but &-'&G o9 the co..a5en in the body

comprises o9 types I1 II1 and III• "ype I co..a5en 6bri.s are stron5er than stee.• Co..a5en is the main 6brous component o9 s?in1 bone1 tendon1 carti.a5e and

periodontium• Co..a5en comprises about '&G o9 the or5anic matri: o9 the bone• Co..a5en is a natura. protein that pro=ides our bodies 2ith structura. support• Co..a5en 5i=es the s?in its stren5th and structure1 and a.so p.ays a ro.e in the

rep.acement o9 dead s?in ce..s• #5in5 is o9 t2o types1 intrinsic and e:trinsic In intrinsic a5in51 co..a5en production

dec.ines 2ith a5e1 and in e:trinsic a5in51 it is reduced by e:posure to u.tra=io.et.i5ht and other en=ironmenta. 9actors• Co..a5en dressin5s 9ascinate ne2 s?in ce..s to 2ound sites• Co..a5en production can be stimu.ated throu5h the use o9 .aser therapy and the

use o9 a.. trans retinoic acid1 a 9orm o9 =itamin #• Sun.i5ht1 smo?in5 and hi5h su5ar consumption reduce co..a5en in body

,"M3$3


5/19


sta55ered 9ashion and cross .in?ed 9or stren5th "he speci6c a.i5nment and de5ree o9 cross-.in?in5 =ary 2ith the tissue Co..a5en consists o9 three chains that intert2ine to9orm a trip.e he.i: (Co..a5en contains about *&&& amino acids1 one third o9 2hich are5.ycine In the ma/ority o9 co..a5ens1 the mo.ecu.es are pac?ed to5ether to 9orm =erysimi.ar .on5 thin 6bri.s

Co..a5en in=o.=es a 9ami.y o9 5enetica..y distinct mo.ecu.es1 a.. o9 2hich ha=e a uni;uetrip.e he.i: con65uration o9 three po.ypeptide subunits ?no2n as a.pha-chains

,ach chain contains around *1&&& amino acids1 and usua..y has an amino acid se;uencecomprisin5 o9 5.ycine1 pro.ine and hydro:ypro.ine

•

%ro.ine he.ps in the 9ormation o9 he.ica. orientation o9 each chain•


6/19


SN"H,SIS 3> C3$$# SN"H,SIS

By dierent 5enes and 9actors

S,8!,NC, 3> IN"R#C,$$!$#R C3$$# ,O"R#C,$$!$#R C3$$#


7/19


• Micro6bri. 9ormation• $ysine hydro:y.ysine termina. NH o:idation (Cu-containin5 .ysy. o:idase)• >ibri. 9ormation• Reducib.e cross-.in? 9ormation• Maturation o9 cross-.in?s•


8/19


• #.thou5h se=era. enEymes are in=o.=ed in the destruction o9 matri: components(Syphi.is) co..a5e brea?do2n is mediated primari.y by the C3$$#


9/19


"his 5roup o9 co..a5ens 9orms banded 6bri.s "heir trip.e he.ica. domain contains anuninterrupted stretch o9 to 4 IBRI$ #SS3CI#",D C3$$##CI")

"his 5roup o9 co..a5ens consists o9 proteins in 2hich co..a5enous domains are interruptedby non-co..a5enous se;uences "hese are associated 2ith the sur9ace o9 6bri. 9ormin5co..a5ens (%sora Sycosis)

It inc.udes type IO1 type OII1 type OI and perhaps type OI a.so "he 9ormer three are

uni;ue in containin5 5.ycosamino5.ycan components co=a.ent.y .in?ed to the proteinmo.ecu.e

#$$ 3"H,R N3N >IBRI$$#R C3$$#!NC"I3NS• %ro=ides structura. support1 stren5th and a de5ree o9 e.asticity1 in combination

2ith e.astin• ,:trace..u.ar matri: co..a5en 9orms a comp.icated net2or? o9 macromo.ecu.es that

determine the physica. properties o9 body tissues• In the dermis1 co..a5en he.ps to 9orm a 6brous net2or?1 upon 2hich ne2 ce..s can

5ro2• Re;uired in the rep.acement and restoration o9 dead s?in ce..s• Some co..a5ens a.so 9unction as protecti=e co=erin5s 9or de.icate or5ans in the

body such as the ?idneys• Co..a5en production natura..y dec.ines 2ith a5e1 reducin5 the structura. inte5rity

o9 the s?in and .eadin5 to sa55in5 s?in1 the 9ormation o9 .ines and 2rin?.es and

© Dr. Rajneesh Kumar Sharma MD (Homoeoa!h"#


10/19


the 2ea?enin5 o9 carti.a5e in /oints1 in ma.es a9ter 4& years o9 a5e and in 9ema.esa9ter menopause

• Its production dec.ines drastica..y a9ter &s causin5 a .ot o9 2rin?.es and a5emar?s

'© Dr. Rajneesh Kumar Sharma MD (Homoeoa!h"#


11/19


C3$$#


12/19


ti5htenin5 o9 the s?in1 /oint pain1 e:a55erated response to co.d (RaynaudFs disease) andheartburn (%sora Sycosis Syphi.is)

Remedies- a.um #nt-c ar5-n ars berb-a brass-n-o Bry caust Crot-t echi ,.aeHydr ?a.i-c .yc petr %hos rad-br ran-b rhus-r sarco.-ac sars sep si. sti..

su.ph syc thiosin thyr :-ray

%3$#R",RI"IS N3D3S#

%o.yarteritis nodosa (%#N) is a rare connecti=e tissue disease that resu.ts in =ascu.itiscausin5 in/ury to or5an systems It is a systemic =ascu.itis characteriEed by necrotiEin5inPammatory .esions that aect medium-siEed and sma.. muscu.ar arteries1 pre9erentia..yat =esse. bi9urcations1 resu.tin5 in microaneurysm 9ormation1 aneurysma. rupture 2ithhemorrha5e1 thrombosis1 and1 conse;uent.y1 or5an ischemia or in9arction (%soraSyphi.is)

Remedies- acon a5ar #..-c am.-ns ant-c #nt-t apis arist-c. #RN #rs-i #RS aur

Bapt B#R-C Bar-m be..-p-sp be..-p B,$$ both BR bu9o cact ca.c-ar Ca.c-9ca.c-p C#$C canth carb-an C#RB- carbn-s card-m Cham Chin ch.am-trch.orpr con= Crot-h Cupr eberth echi euca. >err-p 9err >.-ac 5e.s 5.on5raph 5ua/ Ham hec.a he.. hep HippoE hir hist Hyos i5n inPu ins Iod a.i-c ?a.i-ch. a.i-i ?a.i-m ?a.m ?reos $#CH $ed .ith-c $yc $ycps-= ma5-c ma5-9ma5n-5r merc-cy merc-i-r merc mor5-p morph Mur-ac Nat-i nat-m Nat-snu:-= parathyr %hos p.b-:yE p.b prot %!$S ran-b ran-s rhod RH!S-" rutasacch san5 sec Sep Si. spi5 Spon5 streptoc stront-br stront-c su.-ac su.9aSu.ph syph thiop "hu/ tri.-p tub erat-= ,R#" =ip-a I% Einc

,%ID,RM3$SIS B!$$3S#

,pidermo.ysis bu..osa (,B) is a 5enetic s?in disorder characteriEed c.inica..y by b.ister9ormation 9rom mechanica. trauma (%sora Sycosis)

Remedies- #con a5n ai. a..-c a.um-si. a.um am-c ambr #nac #N"-C #pis arist-c. #rn ars-s-9 ars-s-r #rs #sa9 aur-ar aur-s #ur bad Bar-c Bar-m be..-p be..bery. Bor: bo= Brom bry Bu9o Ca.c camph cann-s Canth carb-an carbn-sC#!S" CH#M che. chin chir-P ch.o. cina C.em cocc co.ch com con corticocroc crot-h crot-t Du.c dys euph 9a.co-pe


13/19


aur-m bac.s-*& bac.s-7 bar-act Be.. BenE-ac berb BR Cact ca/ Ca.c C#$C-%Ca.c-s camph cann-s carbn-s carc Casc cau. C#!S" cedr Cham Che. Chimchin Chinin-s ch.9 Cimic c.em Cocc C3$CH Co.chin Co.oc cor=-cor di5 diosdros Du.c ,up-per euphr 9a5o >err 9err-i >,RR-% 9err-pic 6c-m Pa= >3RM9orm-ac 9ranc 5au. 5e.s 5erm-met 5ins 5onoto: err 5amb 5ast .-ac 5e.s 5.on5raph Ham hec.a hep HippoE hir hist Hyos inPu ins Iod a.i-c ?a.i-ch. a.i-i?a.i-m ?reos $#CH $ed $yc $ycps-= ma5-c ma5-9 merc-cy merc-i-r merc

mor5-p Mur-ac Nat-i nat-m Nat-s nu:-= parathyr %hos prot %!$S rhodRH!S-" sacch san5 sec sep Si. spi5 streptoc stront-br stront-c su.-ac su.9aSu.ph thiop "hu/ tri.-p =erat =ip-a I% Einc

CH!R


14/19


Microscopic po.yan5iitis is an i..-de6ned autoimmune disease characteriEed by asystemic1 pauci-immune1 necrotiEin51 sma..-=esse. =ascu.itis 2ithout c.inica. orpatho.o5ica. e=idence o9 necrotiEin5 5ranu.omatous inPammation (%sora Sycosis)

Remedies- be.. caust Cupr >.-ac hyper ?a.i-br .ach phos su.-ac

%3$M3SI"ISD,RM#"3M3SI"IS

It is a disease characteriEed by inPammation and de5eneration o9 the musc.es Ahen thecondition a.so aects the s?in1 it is ca..ed dermatomyositis (%sora Syphi.is)

Remedies- #rn be.. Bry cimic ham hep ?a.i-i .at-m merc MeE Rhus-tstreptoc thu/ to:o-5

3S",3,C"#

Caused by a mutation in type * co..a5en1 dominant autosoma. disorder1 resu.ts in 2ea?bones and irre5u.ar connecti=e tissue1 can be mi.d or .etha.1 mi.d cases ha=e .o2ered.e=e.s o9 co..a5en type * 2hi.e se=ere cases ha=e structura. de9ects in co..a5en (%sora

Syphi.is)

Remedies- p-benE;

CH3NDR3DS%$#SI#S

Chondrodysp.asia punctaTta is a hetero5eneous 5roup o9 bone dysp.asias1 the commoncharacteristic o9 2hich is stipp.in5 o9 the epiphyses in in9ancy (Syphi.is) "he 5roupinc.udes a se=ere autosoma. recessi=e 9orm (rhiEome.ic d2ar6sm)1 an autosoma.dominant 9orm (Conradi-HUnermann syndrome)1 and a mi.der O-.in?ed 9orm "his s?e.eta.disorder is caused by a mutation in type co..a5en

Remedies- ca.c-phos

,H$,R-D#N$3S SNDR3M,

"he ,h.ers-Dan.os syndromes (,DS) re9er to a 5roup o9 inherited disorders that aectco..a5en structure and 9unction


15/19


It occurs 2hen bones .ose an e:cessi=e amount o9 their protein and minera. content1particu.ar.y ca.cium It is not inherited 5enetica..y1 brou5ht on 2ith a5e1 associated 2ithreduced .e=e.s o9 co..a5en in the s?in and bones (%sora Syphi.is)

Remedies( ar5-met bac.s-7 ca.c-9 cortico cortiso dys P-ac mor5-p pa.o

N3B$3CH SNDR3M,

nob.och syndrome (S) is de6ned by =itreoretina. and macu.ar de5eneration1 andoccipita. encepha.oce.e and is caused by a mutation in the co..a5en OIII 5ene "hepatients present 2ith protrusion o9 the brain tissue and de5eneration o9 the retina1 anindi=idua. 2ith 9ami.y members suerin5 9rom the disorder are at an increased ris?(Sycosis Syphi.is)

Remedies- acon a5ar #rs asa9 aur-s aur Be.. BR Cedr cina Co.oc crot-h di5Dub 9err-p C3$$#


16/19


Co..a5en that is used medica..y can ori5inate 9rom human1 bo=ine1 porcine and o=inesources

SIN >I$$,RS

Co..a5en in/ections can be used in cosmetic procedures to impro=e the contours o9 a5in5s?in

A3!ND DR,SSIN<

Aithin 2ound hea.in51 co..a5en attracts ne2 s?in ce..s to the 2ound site1 promoteshea.in5 and pro=ides a p.at9orm 9or the 5ro2th o9 ne2 tissue

Co..a5en-based membranes ha=e been used in periodonta. and imp.ant therapy topromote the 5ro2th o9 speci6c types o9 ce..

#SC!$#R %R3S"H,"ICS

Co..a5en tissue 5ra9ts 9rom donors ha=e been used in periphera. ner=e re5eneration and=ascu.ar prostheses1 used in arteria. reconstruction

"R,#"M,N" 3> 3S",3#R"HRI"IS

Co..a5en supp.ements or 9ormu.ations may be bene6cia. in the treatment o9 osteoarthritis

SIN R,I"#$IV#"I3N

Many products containin5 co..a5en1 inc.udin5 creams and po2ders1 c.aim to re=ita.iEe thes?in

H3M3,3%#"HIC R,M,DI,S >3R C3$$#


17/19


Chapter ++ Nonatherosc.erotic Coronary Heart Disease W Co..a5en ascu.ar Diseaseascu.itis HurstFs "he Heart1 *e Co..a5en =ascu.ar diseases 5enera..y in=o.=e arthritis1 myositis1carditis1 dermatitis1 and inPammatory =ascu.ar chan5es to =aryin5 de5rees + "hey inc.udesystemic .upus erythematosus1 rheumatoid =ascu.itis1 systemic sc.erosis1 and po.ymyositisRheumatoid =ascu.itis is discussed under

Chapter Co..a5ens1 ,.astic >ibers1 and 3ther ,:trace..u.ar Matri: %roteins o9 the Dermis WCutaneous Co..a5ens Diseases >itEpatric?Fs Dermato.o5y in ibers1 and 3ther ,:trace..u.ar Matri: %roteins o9 the Dermis WitEpatric?Fs Dermato.o5y in au.ty transcription or trans.ation o9 co..a5en type III #ortic andor intestina. rupture

,h.ers-Dan.os type I

Depositiona. Diseases o9 the $un5s W Co..a5en ascu.ar Disease and ImmuneComp.e:Z#ssociated %u.monary Hemorrha5e >ishmanFs %u.monary Diseases and Disorders1 +e o9 these disorders are consistent.y associated 2ith pu.monary hemorrha5e in S$, ,ar.y dia5nosis andtreatment 2ith corticosteroids and cytoto:ic dru5s are associated 2ith 9a=orab.e outcomes1a.thou5h re.apse is not uncommon

,ncyc.opedia Homoeopathica

Hemato.o5ic Disorders W Co..a5en Disorders C!RR,N" Dia5nosis "reatment[ %ediatrics1e Mi.d to .i9e-threatenin5 b.eedin5 occurs 2ith some types o9 ,h.ers-Dan.os syndrome1 themost common inherited co..a5en disorder ,h.ers-Dan.os syndrome is characteriEed by /ointhypermobi.ity1 s?in e:tensibi.ity1 and easy bruisin5 Coa5u.ation abnorma.ities may sometimes bepresent1 inc.udin5

Heritab.e Disorders o9 Connecti=e "issue W 3"H,R C3$$#


18/19


he.ices o9 =aryin5 .en5th and comp.e:ity "he proteins are hetero5eneous both in structure and9unction1 and many are the sites o9 mutations

Heritab.e Disorders o9 Connecti=e "issue W Structure and Biosynthesis o9 >ibri..ar Co..a5ens

HarrisonFs %rincip.es o9 Interna. Medicine >I

%.ate.et Morpho.o5y1 Biochemistry1 and >unction W Co..a5en[


19/19


"he ,:trace..u.ar Matri: W CH3NDR3DS%$#SI#S #R, C#!S,D B M!"#"I3NS IN

Documents

Collagen Disorders and Homoeopathy