Comparison of Hyperpolarized 3He and 129XeMR Imaging in Cystic Fibrosis Patients

Ummul AFIA Shammi MS

Talissa Altes MD

William Hersman PhD

Iulian Russet PhD

John Mugler III PhD

Craig Meyer PhD

Jamie Mata MS

Kun Qing PhD

Robert Thomen PhD

University of Missouri Columbia

Comparison of Hyperpolarized 3He and 129XeMR Imaging in Cystic Fibrosis Patients

▪ Usage of hyperpolarized 3He is not economicallyfeasible because of its unavailability and high price.

▪ We are now motivated to shift towards the use ofcheaper and naturally available 129Xe.

To compare hyperpolarized 3He and 129Xe in patients with cystic fibrosis lung disease by direct voxel-wise correlations and

ventilation defect percentages

Objective

10 patients with CF

(aged 33 ± 8 years)

3He MRI

GREsteady state free

precession (True FISP)

129Xe MRI

129Xe images

GRE images

voxels with signals < 60% of the whole-lung HP gas signal mean → Defects

Defects in 129XeDefects in 3He Matched Defects

Methods

GREsteady state free

precession (True FISP)

Study Population

Image Registration and Segmentation

3He images

True FISP images

Registered to

Registered to

3He GRE 3He True FISP 129Xe GRE 129Xe True FISP

VDP calculation

Common3He only129Xe only

3He VDP 27.5%

129Xe VDP 27.07%

Results

3He VDP 31.5%

129Xe VDP 39.5%

correlation ρ= 0.84P value = 0.0015

correlation ρ= 0.59P value = 3.54×10-10

Sub

ject

8Su

bje

ct 3

3He voxel signals

3He voxel signals

12

9X

e v

oxe

l sig

nal

s1

29X

e v

oxe

l sig

nal

s

Results

50

.8%

43

.9%

52

.1%

56

.3%

49

.5%

61

.1%

68

.2%

62

.1%

62

.1%

49

.8%

62

.7%

65

.7%

65

.4%

67

.8%

68

.1%

70

.1%

32

.5%

35

% 27

.3%

30

%

27

.3% 22

.6%

28

.6%

24

%

21

%

17

.1%

23

%

25

% 22

.4%

17

.7%

19

.1%

18

.6%

7%6.8% 4.6%6.3%

4.2%6.9%

5%5.7% 8.3%

5.3%8.1%8.5%

4.3% 7.4%7.8% 5.7%

8.7% 10.7%14.6%12.2%

7%

14.1%15.8%14% 4.4%7.8% 7.5%12%6.1% 4.8%4.9%4.6% 6.7%

GRE TF GRE TF GRE TF GRE GRE GRE TF GRE GRE TF GRE TF GRE

NormalCommon 3He only

129Xe only

Subj 1 Subj 2 Subj 3 Subj 4 Subj 5 Subj 6 Subj 7 Subj 8 Subj 9 Subj 1044yrs M 31yrs M 30yrs F 23yrs M 33yrs M 28yrs M 50yrs F 26yrs M 36yrs M 32yrs F

m = 1.74m = 1.27m = 0.94

GRE

True FISP

Overall Fitted lineFitted for GREFitted for True FISP

➢On average, VDP was higher in 129Xe scans (33.8% ± 8.3% for 129Xe vs 30.91% ± 5.47% for3He), likely due to the much lower diffusion coefficient of Xenon vs Helium.

➢Although the VDP is higher for 129Xe, the scatter plot (above) shows the similarity betweenthe two gas distributions in all subjects (overall R2 = 0.70, slope= 1.27).

Conclusion

Thank you