COMPLEMENTARY DOCUMENTATION: CVs of Associated … · PROJECT TITLE: Bases moleculares y celulares de los procesos de fusion de epitelios. FINANCIAL ENTITY: Ministerio de Educación

Prof. Emilio Hernández García

T. +34 971 171307 F. +34 971 173248

[email protected] http://ifisc.uib-csic.es/ users/emilio/

IFISC (CSIC-UIB) – Edifici Instituts Universitaris - Campus Universitat Illes Balears - E-07122 Palma de Mallorca , Spain - http://ifisc.uib-csic.es

COMPLEMENTARY DOCUMENTATION: CVs of Associated researchers

Besides the signers of this application, there are in the participating and in related institutions

several senior scientists with genuine interest in the subjects proposed in CCMSysBio, willing to

collaborate in the tasks within their expertise. The CCMSysBio team intends to foster collaborations

with them, taking advantage of their knowledge and experience, so that advances in the proposed

research will be facilitated.

Among these interested scientists we single out, by the contributions that they already have

done during the elaboration of this proposal, the following investigators from the

- Enrique Martín Blanco, Institute of Molecular Biology of Barcelona (IBMB-CSIC)

- Elisa Martí Gorostiza, Institute of Molecular Biology of Barcelona (IBMB-CSIC)

- Carolina Minguillón Gil, Institute of Molecular Biology of Barcelona (IBMB-CSIC)

- Xavier Trepat Guixer, Department of Physiologic Sciences I, University of Barcelona

We enclose here their CVs. Although, by formal reasons, these investigators cannot participate

officially in the present CONSOLIDER proposal, the CCMSysBio team considers them 'Associated

Researchers' to all the effects. Strong collaboration with them is expected during the whole duration

of the project.

Emilio Hernández García, coordinator

on behalf of the CCMSysBio team.

CONSOLIDER-INGENIO 2010

Curriculum vitae

Standardized form Total number of pages: 5 Name: ENRIQUE MARTIN BLANCO Date: JUNE 2009

- During the evaluation process, the applicant could be required to expand and justify the information here contained.

SECRETARÍA DE ESTADODE UNIVERSIDADES E INVESTIGACIÓN SECRETARIA GENERAL DE POLÍTICA CIENTÍFICA Y TECNOLOGICA DIRECCIÓN GENERAL DE INVESTIGACIÓN

PERSONAL DATA Family name: MARTIN BLANCO Forename: ENRIQUE ID/Passport no: 677198D Date of birth : JANUARY 23, 1958 Gender: M Nacionality: SPANISH

PRESENT PROFESIONAL POSITION

Institution: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Faculty, School or Institute: INSTITUTO DE BIOLOGIA MOLECULAR DE BARCELONA Department: BIOLOGIA MOLECULAR Y CELULAR Address: PARC CIENTIFIC DE BARCELONA, C/JOSEP SAMITIER 1-5, BARCELONA 08028 Country: SPAIN Telephone (indicate prefix, number and extension): 34-93-4034973 Fax: 34-93-4034979 E-mail: [email protected] Field of study (UNESCO codes): Profesional status: INVESTIGADOR CIENTIFICO, CSIC

Start date: JULY 2001

Administrative status X Permanent Staff Hired on contracts Acting Fellowship holder Others specify:

Full-time X

PRESENT RESEARCH AREA Brief summary (key words).

DEVELOPMENTAL BIOLOGY, CELL SIGNALING, PATTERN FORMATION, CELL PROLIFERATION, CELL DIFFERENTIATION, JNK SIGNALING, TGFbeta-SIGNALING, TRANSCRIPTIONAL REGULATION, MORPHOGENESIS

ACADEMIC BACKGROUND Bachelor Centre Date LICENCIATURA EN BIOLOGÍA UNIVERSIDAD COMPLUTENSE DE MADRID 1980

GRADO DE LICENCIATURA UNIVERSIDAD COMPLUTENSE DE MADRID 1980 Ph.D. Centre Date DOCTORADO EN BIOLOGÍA UNIVERSIDAD COMPLUTENSE DE MADRID 1986

LANGUAGES (N = NORMAL, G = GOOD, P = PERFECTLY)

Language Speaking Reading Writing ENGLISH P P P

PARTICIPATION IN RESEARCH PROJECTS (selected last ten years) PROJECT TITLE: Bases moleculares y celulares de los procesos de fusion de epitelios. FINANCIAL ENTITY: Ministerio de Educación y Ciencia (PGC PM97-0140) RESEARCH CENTRES: Centro de Biología Molecular (CSIC), LENGHT FROM: 31/12/1998 al 31/12/2001 PRINCIPAL INVESTIGATOR: Antonio García-Bellido PROJECT TITLE: Análisis genético del proceso de cierre dorsal pupal en Drosophila. FINANCIAL ENTITY: Comunidad de Madrid 08.6/0018.1/99 RESEARCH CENTRES: Centro de Biología Molecular, CSIC LENGHT FROM:: 31/12/1999 hasta: 31/12/2000 PRINCIPAL INVESTIGATOR: Antonio García-Bellido PROJECT TITLE: Análisis genético de los procesos de fusión imaginal y de histoblastos en Drosophila FINANCIAL ENTITY: Comunidad de Madrid 08.6/0037./2000 RESEARCH CENTRES: Centro de Biología Molecular, CSIC

LENGHT FROM:: 31/12/2000 hasta: 31/12/2002 PRINCIPAL INVESTIGATOR: Antonio García-Bellido PROJECT TITLE: Analisis comparativo de los procesos de cierre dorsal de discos imaginales en Drosophila y la fusion del paladar en raton. FINANCIAL ENTITY: Fondo de Investigaciones Sanitarias (FIS) 01/1087 RESEARCH CENTRES: Centro de Biología Molecular, CSIC LENGHT FROM:: 31/12/2001 hasta: 31/12/2004 PRINCIPAL INVESTIGATOR: Antonio García-Bellido PROJECT TITLE: Bases moleculares y celulares de los procesos de fusion de epitelios en Drosophila. FINANCIAL ENTITY: Ministerio de Ciencia y Tecnología (BMC2002-01465) RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), LENGHT FROM: 31/12/2002 al 31/12/2005 PRINCIPAL INVESTIGATOR:: Enrique Martín Blanco PROJECT TITLE: Análisis de mecanismos de regulación génica mediados por transducción de señal en Drosophila. FINANCIAL ENTITY:: Acción Estratégica de Genómica y Proteómica. MCYT. GEN2001-4846-C05-03 RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona, CSIC LENGHT FROM:: 31/12/2002 hasta: 31/12/2005 PRINCIPAL INVESTIGATOR: Jordi Casanova Roca PROJECT TITLE: A multi-organism functional genomics approach to study signalling pathways in epithelial fusion/wound healing. FINANCIAL ENTITY: European Union. FP6 PL-503447 RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona, CSIC LENGHT FROM:: 01/01/2004 hasta: 31/12/2007 PRINCIPAL INVESTIGATOR: Enrique Martín Blanco (Coordinator) PROJECT TITLE: Senyalitzacio Cel.lular en Desenvolupament Normal i Patològic FINANCIAL ENTITY: 00840, Grups de Recerca Consolidats, Generalitat de Catalunya RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), LENGHT FROM: 01/01/2005 al 31/12/2008 PRINCIPAL INVESTIGATOR:: Elisa Marti Gorostiza PROJECT TITLE: Bases moleculares y celulares de los procesos de fusion de epitelios. FINANCIAL ENTITY: Ministerio de Educación y Ciencia (BFU2005-04885/BMC) RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), LENGHT FROM: 31/12/2005 al 31/12/2008 PRINCIPAL INVESTIGATOR:: Enrique Martín Blanco PROJECT TITLE: A multi-organism functional genomics approach to study signalling pathways in epithelial fusion/wound healing FINANCIAL ENTITY:: Acción Complementaria al Proyecto BFU2004-0141-E, DGI, MEC RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), Parc Cientific de Barcelona LENGHT FROM: 01/01/2005 al 31/12/2006 PRINCIPAL INVESTIGATOR: Enrique Martín Blanco PROJECT TITLE: From Genes to Shape: analysis of morphogenesis in Drosophila and vertebrates FINANCIAL ENTITY:: CONSOLIDER 2007, CSD-2007-00008. Ministerio de Ciencia e Innovacion RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), Parc Cientific de Barcelona LENGHT FROM: 01/01/2008 al 31/12/2012 PRINCIPAL INVESTIGATOR: Gines Morata PROJECT TITLE: Control celular y molecular de la migracion celular colectiva en desarrollo y cicatrizacion FINANCIAL ENTITY:: BFU2008-02769. Ministerio de Ciencia e Innovacion RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), Parc Cientific de Barcelona LENGHT FROM: 01/01/2009 al 31/12/2011 PRINCIPAL INVESTIGATOR: Enrique Martín Blanco

SELECTED PUBLICATIONS (last ten years)

1. Martín-Blanco, E., Gampel, A., Ring, J. Virdee, K., Tolkovsky, A.M., Kirov, N. and Martinez-Arias, A. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes & Dev. 12, 557-570, 1998

2. Roch, F., Baonza, A., Martín-Blanco, E. and García-Bellido, A. Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125, 1823-1832, 1998

3. Cosgaya, J.M., Aranda, A., Cruces, J. and Martín-Blanco. Neuronal Differentiation of PC12 cells induced by engrailed Homeodomain is independent of MAP Kinases. J. Cell Science 111, 2377-2384, 1998

4. Martín-Blanco E, Jarvis, B. and Martinez-Arias, A. Crossreactivity of anti-dual phosphorylated antibodies with actin. Trends Cell Biol. 8, 419, 1998

5. Martín-Blanco, E., Roch, F., Noll, E., Baonza, A., Duffy, J.B. and Perrimon, N. A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development 126, 5739-5747, 1999

6. Martín-Blanco, E. P38 MAPKs in Development: ancient roles and new functions. Bioessays 22, 637-645, 2000

7. Baonza, A., Roch, F. and Martín-Blanco, E. DER signalling restricts the boundaries of the wing field during Drosophila development. Proc. Natl. Acad. Sci. USA 97, 7331-7335, 2000

8. Martín-Blanco, E., Pastor-Pareja, J.C. and García-Bellido, A. JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila. Proc. Natl. Acad. Sci. USA 97, 7888-7893, 2000

9. García-Bellido, A. y Martín-Blanco, E. Desarrollo Embrionario y Morfogénesis. “La Ciencia en tus manos” P. García-Barreno, Ed. Espasa-Calpe, Madrid, Spain. pp. 565-603, 2000

10. Culi, J., Martín-Blanco, E. and Modolell, J. The EGF receptor and Notch signalling pathways act antagonistically in Drosophila mesothorax bristle patterning. Development 128, 299-308, 2001

11. Martín-Blanco, E. and Knust, E. Epithelial Morphogenesis: Filopodia at work. Curr. Biol. 11, R28-R31, 2001

12. Dobens, L.L., Martín-Blanco, E., Martinez-Arias, A., Kafatos, F.C. and Raftery, L.A. Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis. Development 128, 1845-1856, 2001

13. Pastor-Pareja, J.C., Grawe, F., Martín-Blanco, E. and García-Bellido, A. Cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade. Dev. Cell 7, 387-399, 2004

14. Bosch, M., Serras, F. Martin-Blanco, E., and Baguña, J. JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs. Dev. Biol. 280, 73-86, 2005

15. Pastor-Pareja, J.C., Martín-Blanco, E. and García-Bellido, A. Eversión y cierre de los discos imaginales. Investigación y Ciencia 352, 72-81, 2006

16. Ninov, N, Chiarelli, D. and Martin-Blanco, E. de novo generation of an epithelial layer: hormonal control and cell competition. Development 134, 367-379, 2007

17. Ninov. N, and Martín-Blanco, E. Live imaging of epidermal morphogenesis during the development of the adult abdominal epidermis of Drosophila. Nature Protocols 2, 3074-3080, 2007

18. Llense, F. and Martin-Blanco, E. JNK signaling controls Border Cell cluster integrity and Collective Cell Migration. Current Biology 18, 538-544, 2008

19. Thayil, A.K.N., Cormack, I.G., Pereira, A., Martín-Blanco, E., Mathew, M., Artigas, D. and Loza-Alvarez, P. Decrease in laser ablation threshold for epithelial tissue microsurgery in a living Drosophila embryo during dorsal closure. J. Microscopy 232, 362-368, 2008

20. Chris Bakal, C., Linding, R., Llense, F., Heffern, E., Martin-Blanco, E., Pawson, A., and Perrimon, N. Phosphorilation networks regulating JNK activity in diverse genetic backgrounds. Science 322, 453-456, 2008

21. Ninov. N, , Manjon, C and Martín-Blanco, E. Dynamic control of cell cycle and growth coupling by ecdysone,

EGFR and PI3K signaling in Drosophila histoblasts. PLOS Biology 7, e1000079, 2009.

PARTICIPATION IN RESEARCH CONTRACTS OF SPECIAL RELEVANCE WITH COMPANIES AND/OR PRIVATE OR PUBLIC FUNDING BODIES

CONTRACT TITLE: A multi-organism functional genomics approach to study signalling pathways in epithelial fusion/wound healing PL-503447 FINANCIAL ENTITIES: EUROPEAN COMISSION (Principal Contractor ) CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, CSIC, SPAIN ETH, ZURICH, SWITZERLAND DKFZ, HEIDELBERG, GERMANY IMGB, FRANCE CIEMAT, SPAIN FUNDACION INSTITUTO LELOIR, ARGENTINA SWITCH BIOTECH, GERMANY ALMA BIOINFORMATICS, SPAIN LENGHT FROM: 2004 TO: 2007 PRINCIPAL INVESTIGATOR: ENRIQUE MARTIN BLANCO

THESIS SUPERVISED TITLE: ANALISIS CELULAR DE LOS PROCESOS DE EVERSION Y CIERRE DE LOS DISCOS IMAGINALES EN DROSOPHILA Ph. D. STUDENT: JOSÉ CARLOS PASTOR PAREJA UNIVERSITY: UNIVERSIDAD AUTONOMA DE MADRID FACULTY/SCHOOL: FACULTAD DE BIOLOGÍA YEAR: 2004 MARK: APTO CUM LAUDE TITLE: THE REGULATORY ROLE OF THE JNK SIGNALING CASCADE IN CELL MIGRATION DURING MORPHOGENESIS IN DROSOPHILA Ph. D. STUDENT: FLORA LLENSE UNIVERSITY: UNIVERSIDAD DE BARCELONA FACULTY/SCHOOL: FACULTAD DE BIOLOGÍA YEAR: 2008 MARK: APTO CUM LAUDE TITLE: CELLULAR AND GENETIC ANALYSIS OF THE PROCESS OF HISTOBLAST FUSION AND EXPANSION DURING METAMORPHOSIS IN DROSOPHILA Ph. D. STUDENT: NIKOLAY NINOV UNIVERSITY: UNIVERSIDAD DE BARCELONA FACULTY/SCHOOL: FACULTAD DE BIOLOGÍA YEAR: 2008 MARK: APTO CUM LAUDE



Curriculum vitae

Standardized form Total number of pages: 5 Name: ELISA MARTÍ GOROSTIZA Date: JUNE 2009


PERSONAL DATA Family name: MARTÍ GOROSTIZA Forename: ELISA ID/Passport no: 42064032E Date of birth : JANUARY 11, 1961 Gender: F Nacionality: SPANISH


Institution: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Faculty, School or Institute: INSTITUTO DE BIOLOGIA MOLECULAR DE BARCELONA Department: BIOLOGIA MOLECULAR Y CELULAR Address: PARC CIENTIFIC DE BARCELONA, C/JOSEP SAMITIER 1-5, BARCELONA 08028 Country: SPAIN Telephone (indicate prefix, number and extension): 34-93-4034972 Fax: 34-93-4034979 E-mail: [email protected] Field of study (UNESCO codes): Profesional status: INVESTIGADOR CIENTIFICO, CSIC

Start date: NOVEMBER 2006

Administrative status X Permanent Staff Hired on contracts Acting Fellowship holder Full-time X


DEVELOPMENTAL NEUROBIOLOGY, CELL SIGNALING, CELL PROLIFERATION, CELL MIGRATION PATTERN FORMATION, NEURAL CREST

ACADEMIC BACKGROUND Bachelor Centre Date LICENCIATURA EN BIOLOGÍA UNIVERSIDAD DE LA LAGUNA 1982

GRADO DE LICENCIATURA UNIVERSIDAD DE LA LAGUNA 1984 Ph.D. Centre Date DOCTORADO EN BIOLOÍA UNIVERSIDAD DE LA LAGUNA 1988

PAST SCIENTIFIC EXPERIENCE (*)

Position R&D Centre Institution (**) Start date End date

PREDOCTORAL FELLOW Royal Postgradute Medical School LONDON UNIVERSITY 1985 1986

PREDOCTORAL FELLOW Dept. Biología Celular UNIVERS LALAGUNA 1987 1988 POSTDOCTORAL FELLOW

Dept. Anatomía y Embriología

UNIVERSITA DI TORINO 1988 1989

Profr Titular Int Univers Dept. Biología Celular, UNIVERS LALAGUNA 1989 1993

Prof Titular Universidad Dept. Biología Celular, UNIVERS LALAGUNA 1993 1994 POSTDOCTORAL FELLOW

Molecular and Celular Biology Dept

HARVARD UNIVERSITY 1994 1998

Investigador Contratad CAJAL INSTITUTE CSIC 1998 2001

Científico Titular IBMB CSIC 2001 2006


Language Speaking Reading Writing ENGLISH G G G

PARTICIPATION IN RESEARCH PROJECTS (selected LAST 10 YEARS)

PROJECT TITLE: Desarrollo temprano del sistema nervioso de vertebrados: control genético del crecimiento, diferenciación y morfología celular en el tubo neural. FINANCIAL ENTITY: BFU2007-60487/BMC RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC) LENGHT FROM: Dec/2007 al Dec/2010 PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza PROJECT TITLE: Estudio de la señalización celular en la diferenciación de motoneuronas espinales, del desarrollo embrionario a la biología de células madre FINANCIAL ENTITY: Fundación La Caixa (BM05-52-0) RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC) LENGHT FROM: 01/01/2006 al 31/12/2008 PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza PROJECT TITLE: Desarrollo temprano del Sistema Nervioso de Vertebrados: control genético de la proliferación, determinación y diferenciación celular en el tubo neural. FINANCIAL ENTITY: Ministerio de Educación y Ciencia (BFU2004-00455/BMC) RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona (CSIC), LENGHT FROM: 13/12/2004 al 13/12/2007 PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza PROJECT TITLE: Genetic Mechanisms that determine neuronal progenitor identity in the ventral Spinal Cord. FINANCIAL ENTITY: EU BioTech-Grant QLRT-2002-01141 RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona, CSIC LENGHT FROM: 27/09/2002 hasta: 31/03/2006 PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza PROJECT TITLE: Estudio de la señalización del morfógeno Sonic hedgehog en el desarrollo normal y patológico del cerebelo. FINANCIAL ENTITY: Ministerio de Ciencia y Tecnología (BMC2001-1354) RESEARCH CENTRES: Instituto de Biología Molecular de Barcelona, CSIC LENGHT FROM:: 28/12/2001 hasta: 27/12/2004 PRINCIPAL INVESTIGATOR: Elisa Martí Gorostiza

SELECTED PUBLICATIONS (last 10 years) 13.- E. Martí, D.A. Bumcrot, R. Takada, A.P. McMahon. Requirement of 19K Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature, 375, 322-325 (1995) News and Views: Nature 1995 May 25;375(6529):279-80 14.- E. Martí, R. Takada, D.A. Bumcrot, H. Sasaki, A.P. McMahon. Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development, 121, 2537-2547 (1995) 17.- D.J. Epstein, E. Martí, M.P. Scott, A.P. McMahon. Antogonizing cAMP-dependent protein Kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122, 2885-2894 (1996). 19.- Y. Yang, G. Drossopoulou, P-T. Chuang, D. Duprez, E. Martí , D. Bumcrot, Vangersson, N., Clarke, J, L. Niswander, A.P. McMahon, C. Tickle. Relationship between dose, distance and time in Sonic hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404 (1997). 20.- J.R. Martínez-Moráles, J.A. Barbas, E. Martí, P. Bovolenta, D. Edgar, A. Rodríguez-Tebar. Vitronectin acts downstream of Sonic hedgehog to induce differentiation of motor neurons. Development 124, 5139-5147 (1997) Coment in: Current Opinion in Neurobiology 1998, 8:1-10

21. - Oppenheim., R.W., Homma, S., Martí, E., Prevette, D., Wang, S., Yaginuma, H., McMahon, A.P. Modulation of early but not late stages of programmed cell death in embryonic avian spinal cord by Sonic hedgehog. Molecular Cellular Neuroscience 13: 384-361 (1999) 22.- E. Martí. The chick BMP1/Tolloid family of metalloproteases are expressed in CNS signalling centres. Mechanisms of Development 91: 415-419 (2000) 23.- Pons S., Martí E. Sonic hedgehog synergizes with the extracellular matrix protein Vitronectin, to induce spinal motor neuron differentiation. Development 127: 333-342 (2000) 24.- Pons, S., Trejo, J.L., J.R. Martínez-Morales, Martí E. Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation Development 128:1481-1492 (2001) Cover Picture Coment in: Trends in Neurosciences 24 (12) 2001, 680 -682 25.- Martí E*., Trousse, F*., Gruss, P., Torres, M. Bovolenta P. Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. Development 128: 3927-3936 (2001) Cover Picture Coment in: Nat. Neurosc. Rev. 2001, 2, 853 26.- Elisa Martí and Paola Bovolenta Sonic hedgehog in CNS development: One signal, multiple outputs Trends in Neuroscience (Review) 25(2): 89-96 (2002) 28.- Iria Rios, Rubén Alvarez, Sebastián Pons and Elisa Martí. BMP2 antagonizes Sonic hedgehog proliferation of granule neurones through Smad5 signalling. Development 131, 3159-3168 (2004) 29.- Elisa Martí, Lidia García-Campmany and Paola Bovolenta Dorso-ventral patterning of the vertebrate nervous system. In: “Cell signalling and growth factors in development” Klaus Unsicke and Kerstin Kligestein (Eds). Wiley-VCH. Growth Fact 2Vol, ISBN 3-527-31034-7 pp. 361-394 (2005) 30.- Jordi Cayuso and Elisa Martí. Morphogens in motion: growth control of the neural tube J.Neurobiology, (Review) 64(4):376-387 (2005) 31.- Paola Bovolenta and Elisa Martí Un-expected roles for morphogens in development and regeneration of the CNS. Introduction to the Special Issue. J. Neurobiology. 64(4):321-323 (2005) 32.- Jordi Cayuso, Fausto Ulloa, Barny Cox, James Briscoe, Elisa Martí The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development 133, 517-528 (2006) 33.- Lidia García-Campmany and Elisa Martí The TGFb-intracellular effector Smad3 regulates neuronal differentiation and cell fate decisions in the developing spinal cord. Development 134, 65-75 (2006) 34.- Roberto Alvarez-Medina, Jordi Cayuso, Tadashi Okubo, Shinji Takada and Elisa Martí. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 135, 237-247 (2008) Cover Picture Coment in: Development 2008 135: 202. 35.- Fausto Ulloa and Elisa Martí Wnt Won the War: antagonistic role of Wnt over Shh controls dorso-ventral patterning of the vertebrate neural tube. Develompental Dynamics (in press) 2009-06-29

PARTICIPATION IN RESEARCH CONTRACTS OF SPECIAL RELEVANCE WITH COMPANIES AND/OR PRIVATE OR PUBLIC FUNDING BODIES

CONTRACT TITLE: Genetic Mechanisms that determine neuronal progenitor identity in the ventral Spinal Cord. , EU BioTech-Contract Nº QLG3-CT-2002-01141 FINANCIAL ENTITIES: EUROPEAN COMISSION (Principal Contractor ) The Cyrpus Institute of Neurology and Genetics, Cyprus The Medical Reseach Council, MRC-NIMR.DDN, United Kingdom The Karolinska Institute (KI), Sweden Consejo Superior de Investigaciones Científicas (CSIC), España Hybrigenics SA (HGX), France Reneuron Limited (RENEU), United Kingdom Universite of Milano-Bicocca (UNIMIB), Italy LENGHT FROM: 2002 TO: MARCH 2006 PRINCIPAL INVESTIGATOR: Dr. Stavros Malas

PATENTS AND UTILITY MODELS INVENTORS (in order of authorship): Andrew McMahon, David Bumcrot, Elisa Martí TITLE: Vertebrate Tissue Pattern-Inducing proteins, and uses related thereto APPLICATION FORM No: PRIORITY COUNTRY: USA PRIORITY DATE: HOLDER ENTITY: HARVARD UNIVERSITY OTHER COUNTRIES WHICH THE PATENT HAS BEEN EXTENDED TO: USA COMPANIES THAT ARE LICENSING IT: Biogen inc., Ontogeny-Curis In

THESIS SUPERVISED TITLE: “New roles of the Shh pathway in the development of the vertebrate caudal neural tube” Ph. D. STUDENT: Jordi Cayuso Más UNIVERSITY: Universidad de Barcelona FACULTY/SCHOOL: Programa de Doctorado en Genética YEAR: 2006 MARK: APTO CUM LAUDE TITLE: “Integration of Shh and Wnt pathways controls morphogenesis of the CNS” Ph. D. STUDENT: Roberto Alvarez Medina UNIVERSITY: Universidad de Barcelona FACULTY/SCHOOL: Programa de Doctorado en Genética YEAR: 2008 MARK: APTO CUM LAUDE TITLE: “Role of the TGFb intracellular effectors in neuronal differentiation in the developing spinal cord” Ph. D. STUDENT: Lidia García Campmany UNIVERSITY: Universidad de Barcelona FACULTY/SCHOOL: Programa de Doctorado en Genética YEAR: 2009 MARK: APTO CUM LAUDE


Curriculum vitae

Standardized form Total number of pages: 5 Name: CAROLINA MINGUILLÓN GIL Date: JUNE 2009



PERSONAL DATA Family name: MINGUILLÓN GIL Forename: CAROLINA ID/Passport no: 38088620E Date of birth : 28th, FEBRUARY, 1975 Gender: F Nacionality: SPANISH


Institution: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Faculty, School or Institute: INSTITUTO DE BIOLOGIA MOLECULAR DE BARCELONA Department: BIOLOGIA MOLECULAR Y CELULAR Address: PARC CIENTIFIC DE BARCELONA, C/ BALDIRI REIXAC, 10, BARCELONA 08028 Country: SPAIN Telephone (indicate prefix, number and extension): 34-93-4020234 Fax: 34-93-4034979 E-mail: [email protected] Field of study (UNESCO codes): 240105, 240107, 240108, 240901, 240902, 240991 Profesional status: INVESTIGADOR RAMÓN Y CAJAL Start date: NOVEMBER 2007 Administrative status

Permanent Staff Hired on contracts Acting Fellowship holder Others specify:

Full-time PRESENT RESEARCH AREA

Brief summary (key words). DEVELOPMENTAL BIOLOGY, VERTEBRATE LIMB DEVELOPMENT, CELL MIGRATION, MOLECULAR BIOLOGY

ACADEMIC BACKGROUND Bachelor Centre Date Biology University of Barcelona 1997 Ph.D. Centre Date PhD in Biology (European Mention Awarded) Genetics Department, University of Barcelona 2002


Position R&D Centre Institution (**) Start date End date Undergraduate Student Genetics Department University of Barcelona 1996 1997

PhD Student Genetics Department University of Barcelona 1998 2002

MRC Postdoctoral Fellow National Institute for Medical Research

Medical Research Council, UK 2002 2003

EMBO Postdoctoral Fellow National Institute for Medical Research


MRC Career Development Fellow

National Institute for Medical Research



Language Speaking Reading Writing ENGLISH P P P

PARTICIPATION IN RESEARCH PROJECTS (selected LAST 10 YEARS) Título del proyecto: Los factores neurotróficos y sus vías de traducción de señal como dianas terapéuticas en el tratamiento de enfermedades neurodegenerativas Entidad financiadora: Fundació la Marató de TV3 Entidades participantes: Universitat de Barcelona, Universitat de Lleida Duración, desde: 1999 hasta: 2001 Cuantía de la subvención: 22.500.000 ptas Investigador responsable: Jordi Garcia-Fernàndez y Joan Comella Título del proyecto: La superfamilia génica Hox en el prevertebrado arquetípico anfioxo. Entidad financiadora: Ministerio de Educación y Cultura Entidades participantes: Universitat de Barcelona Duración, desde: 1999 hasta: 2002 Cuantía de la subvención: 9.000.000 ptas Investigador responsable: Jordi García-Fernàndez Título del proyecto: Grups de Recerca de Qualitat. Grup de Biologia i Genètica del Desenvolupament Entidad financiadora: Generalitat de Catalunya Entidades participantes: Universitat de Barcelona Duración, desde: 2000 hasta: 2001 Cuantía de la subvención: 3.200.000 ptas Investigador responsable: Jaume Baguñà Título del proyecto: Búsqueda de genes relacionados con IPF-1 (insulin promoter factor-1): implicacione sen la regulación del gen de la insulina y en la diabetes de tipo 2 Entidad financiadora: Fundació la Marató de TV3 Entidades participantes: Universitat de Barcelona Duración, desde: 2000 hasta: 2002 Cuantía de la subvención: 18.091.540 ptas Investigador responsable: Jordi García-Fernàndez y Gemma Marfany Título del proyecto: Formación del patrón mesodérmico en el arquetipo anfioxo Entidad financiadora: Ministerio de Educación y Cultura (Acciones Integradas Hispano Británicas) Entidades participantes: Universitat de Barcelona, University of Reading Duración, desde: 2000 hasta: 2002 Cuantía de la subvención: 1.290.000 ptas Investigador responsable: Jordi Garcia-Fernàndez

Título del proyecto: Desarrollo del sistema nervioso en cordados Entidad financiadora: Ministerio de Asuntos Exteriores (Proyectos conjuntos de cooperación científico-técnica España-Italia) Entidades participantes: Universitat de Barcelona, Duración, desde: 2002 hasta: 2004 Cuantía de la subvención: importe sin determinar Investigador responsable: Jordi García-Fernàndez Título del proyecto: The role of Tbx genes in limb development and disease Entidad financiadora: European Molecular Biology Organisation (Young Investigador Programme) Entidades participantes: MRC-National Institute for Medical Research Duración, desde: 2003 hasta: 2006 Cuantía de la subvención: 45.000€ Investigador responsable: Malcolm Logan Título del proyecto: Vertebrate Limb Development Entidad financiadora: Medical Research Council (UK) Entidades participantes: MRC-National Institute for Medical Research Duración, desde: 2001 hasta: … Cuantía de la subvención: importe sin determinar Investigador responsable: Malcolm Logan Título del proyecto: Genómica comparada de los complejos Tbx. Entidad financiadora: Ministerio de Ciencia y Tecnología (ayuda adicional programa Ramón y Cajal) Entidades participantes: CSIC- Instituto de Biología Molecular de Barcelona Duración, desde: 2007 hasta: 2009 Cuantía de la subvención: 15.000€ Investigador responsable: Carolina Minguillón Título del proyecto: Genómica comparada de los complejos Tbx: una aproximación funcional multi-disciplinaria Entidad financiadora: Ministerio de Ciencia y Tecnología Entidades participantes: CSIC- Instituto de Biología Molecular de Barcelona Duración, desde: 2009 hasta: 2011 Cuantía de la subvención: 90.000€ Investigador responsable: Carolina Minguillón

SELECTED PUBLICATIONS (last 10 years) • Minguillón, C., Gibson-Brown, J.J. and Logan, M.P. Tbx4/5 Gene Duplication and the Origino f Vertebrate

Limbs. In preparation • Minguillón, C., Wood, S., Vendrell, E., Gibson-Brown, J.J. and Logan, M.P. Hox Genes Regulate the

Forelimb-specific Expression of Tbx5. Submitted to Developmental Cell • Garcia-Fernàndez, J., D’Aniello, S., Jiménez-Delgado, S., Pascual-Anaya, J., Maeso, I., Irimia, M., Minguillón,

C., Benito-Gutiérrez, E., Gardenyes, J. and Bertrand, S. (2008). From the American to the European Amphioxus: towards Experimental Evo-Devo at the origin of Chordates. International Journal of Developmental Biology. In press

• Horton AC, Mahadevan NR, Minguillon, C., Osoegawa K, Rokhsar DS, Ruvinsky I, de Jong PJ, Logan MP, Gibson-Brown JJ. (2008). Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs. Dev Genes Evol 218:613-628.

• Minguillón, C., Del Buono, J. and Logan, M.P. (2005). Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Dev. Cell 8:75-84.

• Minguillón, C., Gardenyes, J., Serra, E., Castro, L.F., Hill-Force, A., Holland, P.W., Amemiya, C.T. and Garcia-Fernandez, J. (2005). No more than 14: the end of the amphioxus Hox cluster. Int. J. Biol. Sci. 1:19-23.

• Minguillón, C and Logan, M.P. (2004). Developmental biology reaches new lineages. Genome Biol. 5:333.

• Minguillón, C and Logan, M.P. (2003). The comparative genomics of T-box genes. Brief. Funct. Genomics and Proteomic. 2:224-33.

• Ferrier, D.E. and Minguillón, C. (2003). Evolution of the Hox/ParaHox gene clusters. Int. J. Dev. Biol. 47:605-11.

• Minguillón, C., Jimenez-Delgado, S., Panopoulou, G., Garcia-Fernàndez, J. (2003). The amphioxus Hairy family: differential fate after duplication. Development 130:5903-14.

• Minguillón, C. and Garcia-Fernàndez, J. (2003). Genesis and evolution of the Evx and Mox genes and the extended Hox and ParaHox gene clusters. Genome Biol. 4:R12.

• Minguillón, C and Garcia-Fernàndez, J. (2002). The single amphioxus Mox gene: insights into the functional evolution of Mox genes, somites, and the asymmetry of amphioxus somitogenesis. Dev. Biol. 246:455-65.

• Minguillón, C., Ferrier, D.E., Cebrián, C. and Garcia-Fernàndez, J. (2002). Gene duplications in the prototypical cephalochordate amphioxus. Gene 287:121-8.

• Ferrier, D.E., Minguillón, C., Cebrián, C. and Garcia-Fernàndez, J. (2001). Amphioxus Evx genes: implications for the evolution of the Midbrain-Hindbrain Boundary and the chordate tailbud. Dev. Biol. 237:270-81.

• Garcia-Fernàndez, J., Ferrier, D.E.K., Minguillón, C. and Cebrián, C. (2001). The amphioxus genome in Evo-Devo: archetype or “cul de sac”? Int. J. Dev. Biol. 41: S137-S138.

• Garcia-Fernàndez, J., Ferrier, D.E.K., Minguillón, C., Holland, P.W.H. and Wada, H. (2001). The amphioxus genome has both archetypal and derived features. Zool. Sci. 18: 454-455.

• Ferrier, D.E., Minguillón, C., Holland, P.W. and Garcia-Fernàndez, J. (2000). The amphioxus Hox cluster: deuterostome posterior flexibility and Hox14. Evol. Dev. 2:284-93.


Curriculum vitae

Standardized form Total number of pages: 5 Name: XAVIER TREPAT GUIXER Date: JUNE 2009


SECRETARÍA DE ESTADO DE UNIVERSIDADES E INVESTIGACIÓN SECRETARIA GENERAL DE POLÍTICA CIENTÍFICA Y TECNOLOGICA DIRECCIÓN GENERAL DE INVESTIGACIÓN

PERSONAL DATA Family name: TRPEAT GUIXER Forename: XAVIER ID/Passport no: 38132266Z Date of birth : MARCH 28, 1976 Gender: M Nacionality: SPANISH


Institution: UNIVERSITAT DE BARCELONA Faculty, School or Institute: FACULTAT DE MEDICINA Department: CIENCIAS FISIOLÓGICAS I Address: C/ CASANOVA 143, 08036 BARCELONA Country: SPAIN Telephone (indicate prefix, number and extension): 34-93-4020265 Fax: 34-93-4037181 E-mail: [email protected] Field of study (UNESCO codes): Profesional status: RAMON Y CAJAL INVESTIGATOR Start date: JULY 2008 Administrative status Hired on contracts Acting Fellowship holder Others specify: RAMON Y CAJAL INVESTIGATOR Full-time X


CELL MECHANICS, CELL MIGRATION, COLLECTIVE PROCESSES, EPITHELIAL REPAIR, NANOTEHCNOLOGY.

ACADEMIC BACKGROUND Bachelor Centre Date LICENCIADO EN FÍSICA UNIVERSIDAD DE BARCELONA 08-02-2000 LICENCIADO EN INGENIERÍA SUPERIOR ELECTRÓNICA UNIVERSIDAD DE BARCELONA 20-11-2002

Ph.D. Centre Date

DOCTOR POR LA UNIVERSIDAD DE BARCELONA

FACULTAD DE MEDICINA, UNIVERSIDAD DE BARCELONA, (PREMIO EXTRAORDINARIO DE DOCTORADO).

14-06-2004


Position R&D Centre Institution (**) Start date End date BECARIO PREDOCTORAL FPI

FACULTAD DE MEDICINA

UNIVERSIDAD DE BARCELONA

01/07/2000 30/06/2004

RESEARCH FELLOW SCHOOL OF PUBLIC HEALTH

HARVARD UNIVERSITY 07/09/2004 30/06/2006

RESEARCH ASSOCIATE SCHOOL OF PUBLIC HEALTH

HARVARD UNIVERSITY 01/07/2006 30/07/2008

INVESTIGADOR RAMÓN Y CAJAL

FACULTAD DE MEDICINA

UNIVERSIDAD DE BARCELONA 31/07/2008 -


Language Speaking Reading Writing SPANISH P P P

CATALAN P P P

FRENCH P P P

ENGLISH P P P PARTICIPATION IN RESEARCH PROJECTS (selected LAST 10 YEARS)

PROJECT TITLE: Estudio de la mecánica de la vía aérea superior en el síndrome de apneas-hipopneas durante el sueño y optimización de su tratamiento mediante presión nasal dependiente de flujo. FINANCIAL ENTITY: Ministerio de Ciencia y Tecnología RESEARCH CENTRES: Universidad de Barcelona LENGTH FROM 1999 to 2002 PRINCIPAL INVESTIGATOR: Ramon Farré PROJECT TITLE: Micromechanics of airway smooth muscle cells in culture FINANCIAL ENTITY: NIH-USA. HL65960 RESEARCH CENTRES: Harvard University, Universidad de Barcelona, Dalhousie University, University of Erlangen-Nuernberg LENGTH FROM 2005 to 2009 PRINCIPAL INVESTIGATOR: Jeffrey J Fredberg PROJECT TITLE: Mecanismos de ruptura de la barrera epitelial alveolar por sobredistensión. FINANCIAL ENTITY: Ministerio de Ciencia e Innovación RESEARCH CENTRES: Universidad de Barcelona LENGTH FROM: 2008 to 2012 PRINCIPAL INVESTIGATOR: Xavier Trepat

SELECTED PUBLICATIONS (last 10 years) 1.- Farre R, Montserrat JM, Rigau J, Trepat X, Pinto P, Navajas D. Response of automatic continuous positive airway pressure devices to different sleep breathing patterns: A bench study. Am J Respir Crit Care Med 166 (4), 469 (2002). 2.- Alcaraz J, Buscemi L, Grabulosa M, Trepat X, Fabry B, Farre R, Navajas D. Microrheology of human lung epithelial cells measured by atomic force microscopy. Biophys J 84 (3), 2071 (2003). 3.- Trepat X, Grabulosa M, Buscemi L, Rico F, Fabry B, Fredberg JJ, Farre R. Oscillatory magnetic tweezers based on ferromagnetic beads and simple coaxial coils. Rev Sci Instrum 74 (9), 4012 (2003). 4.- Rigau J, Farre R, Trepat X, Shusterman D, Navajas D. Oscillometric assessment of airway obstruction in a mechanical model of vocal cord dysfunction. J Biomech 37 (1), 37 (2004). 5.- Trepat X, Grabulosa M, Puig F, Maksym GN, Navajas D, Farre R. Viscoelasticity of human alveolar epithelial cells subjected to stretch. Am J Physiol Lung Cell Mol Physiol 287 (5), L1025 (2004). 6.- Trepat X, Grabulosa M, Buscemi L, Rico F, Farre R, Navajas D. Thrombin and histamine induce stiffening of alveolar epithelial cells. J Appl Physiol 98 (4), 1567 (2005). 7.- An SS, Fabry B, Trepat X, Wang N, Fredberg JJ. Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol 35 (1), 55 (2006). 8.- Deng L, Trepat X, Butler JP, Millet E, Morgan KG, Weitz DA, Fredberg JJ. Fast and slow dynamics of the cytoskeleton. Nature Mater 5 (8), 636 (2006). News and Views: Nature Materials 5, 597 - 598 (2006) 9.- Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D. Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin. Am J Physiol Lung Cell Mol Physiol 290 (6), L1104 (2006). 10.- Bursac P, Fabry B, Trepat X, Lenormand G, Butler JP, Wang N, Fredberg JJ, An SS. Cytoskeleton dynamics: Fluctuations within the network. Biochem Biophys Res Commun 355 (2), 324 (2007).

11.- Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, Fredberg JJ. Universal physical responses to stretch in the living cell. Nature 447 (7144), 592 (2007). Editorial: Nature 448, 969-970 (2007) 12.- Krishnan R, Trepat X, Nguyen TT, Lenormand G, Oliver M, Fredberg JJ. Airway smooth muscle and bronchospasm: Fluctuating, fluidizing, freezing. Respir Physiol Neurobiol 163 (1-3), 17 (2008). 13.- Lenormand G, Alencar AM, Trepat X, Zhou E, Fabry B, Butler JP, Fredberg JJ, The cytoskeleton of the living cell as an out-of-equilibrium system; in Phase transitions in cell biology, edited by Pollack, GH,Chin, W (Springer Netherlands, 2008), pp. 111. 14.- Trepat X, Farre R. Alveolar permeability and stretch: Too far, too fast. Eur Respir J 32 (4), 826 (2008). 15.- Trepat X, Lenormand G, Fredberg JJ. Universality in cell mechanics. Soft Matter 4, 1750 (2008). 16.- An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, Biswal S. Cell stiffness, contractile stress and the role of extracellular matrix. Biochem Biophys Res Commun 382 (4), 697 (2009). 17.- Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, Trepat X, Lenormand G, Tambe D, Smolensky AV, Knoll AH, Butler JP, Fredberg JJ. Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS ONE 4 (5), e5486 (2009). 18.- Trepat X, Wasserman MR, Angelini TE, Millet E, Weitz DA, Butler JP, Fredberg JJ. Physical forces during collective cell migration. Nature Phys 5, 426 (2009). Cover Picture News and Views: Nature Physics 5, 377 - 378 (2009) 19.- Zhou EH, Trepat X, Park CY, Lenormand G, Oliver MN, Mijailovich SM, Hardin C, Weitz DA, Butler JP, Fredberg JJ. Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition. Proc Natl Acad Sci U S A (in press).

PARTICIPATION IN RESEARCH CONTRACTS OF SPECIAL RELEVANCE WITH COMPANIES AND/OR

PRIVATE OR PUBLIC FUNDING BODIES

CONTRACT TITLE: Evaluation of the accuracy of the impedance signal obtained by Somnosmart FINANCIAL ENTITIES: Weinmann (Germany) PRINCIPAL CONTRACTOR: Universitat de Barcelona LENGHT FROM :2001 to 2001 PRINCIPAL INVESTIGATOR: Dr Ramon Farré CONTRACT TITLE: Study on instrumentation for nasal pressure therapy in respirtory sleep diseases. FINANCIAL ENTITIES: Measurement, Check & Control (MCC), Germany PRINCIPAL CONTRACTOR: Universitat de Barcelona LENGHT FROM :2001 to 2001 PRINCIPAL INVESTIGATOR: Dr Ramon Farré

Documents

COMPLEMENTARY DOCUMENTATION: CVs of Associated … · PROJECT TITLE: Bases moleculares y celulares de los procesos de fusion de epitelios. FINANCIAL ENTITY: Ministerio de Educación