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Complete revascularisation in STEMI with multivessel disease should be performed in the middle of the night : The case AGAINST Nick West Papworth Hospital Cambridge, UK

Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

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Page 1: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Complete revascularisation in STEMI with multivessel disease should be

performed in the middle of the night :

The case AGAINST

Nick West Papworth HospitalCambridge, UK

Page 2: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

NO  CONFLICTS  TO  DECLARE

Page 3: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Even John McEnroe agrees it’s daft

Page 4: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

So why is it such a bad idea?

• Level of evidence

• RCTs vs registries?

• Cath lab team wear and tear

• Impact on working day

• Pragmatic factors

Page 5: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Eminent Cardiologist Tired Tony thinks:

How can I stay in bed?

Page 6: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Eminent Cardiologist Tired Tony thinks:

How can I stay in bed?

OK that didn’t work out…

How about letting the paramedics do

the work?

Maybe if we just lyse them again –

or even do nothing?

One last go…I’m sure we can get

away with just doing the culprit...

Page 7: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

CvLPRIT PRAMI

Where the madness started…

Page 8: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 9: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 10: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 11: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 12: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 13: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 14: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

CvLPRIT: 1 in 3 includedPRAMI: 1 in 5 included

(…and btw nearly 50% had 1 VD only)

Page 15: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Interventional pragmatism

Page 16: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Interventional pragmatism #2

Page 17: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Interventional pragmatism #3

Page 18: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 19: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Seduced by CLeOPatR(a)??

‘Our courteous Antony, whom ne’er the word of ‘No’ woman heard speak…’William Shakespeare

Page 20: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 21: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

So why is it such a bad idea?

• Level of evidence

• RCTs vs registries?

• Cath lab team wear and tear

• Impact on working day

• Pragmatic factors

Page 22: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274
Page 23: Complete revascularisation in STEMI with multivessel ...CV1-o CV1-s Log-rank test p=O.007 500 CV1-o CVl-s 700 833 3160 314 10 Number at risk: 300 400 Follow-up (days) 100 1207 4274

Tired Tony says:

“Leave it to the physicians;Physicians are very good at making decisions”