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Completion of Skeletal Muscle and comparison to Smooth Muscle. Outline. Classification of Skeletal muscle Slow twitch versus fast twitch Oxidative versus glycolytic Skeletal Muscle Genetic Diseases Smooth Muscle Types of smooth muscle cells Smooth muscle contraction - PowerPoint PPT Presentation
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Completion of Skeletal Muscle and comparison to Smooth Muscle
Outline
Classification of Skeletal muscle Slow twitch versus fast twitch Oxidative versus glycolytic
Skeletal Muscle Genetic Diseases
Smooth Muscle Types of smooth muscle cells Smooth muscle contraction Smooth muscle relaxation
Smooth muscle compared to Skeletal Muscle
Classification of skeletal muscle
Speed of contraction
Resistance to Fatigue
Which type of muscle fibers are used for these two activities?
Fast Twitch Slow Twitch
Weight liftingPianist
Muscular Disease
Muscular Dystrophy Sex linked recessive Dystrophin is mutated
Myasthenia Gravis Decreased number of acetylcholine receptors
TYPES OF SMOOTH MUSCLE CELLS
SMOOTH MUSCLE CONTRACTION
NO SARCOMERES!Presence of Dense Bodies EXTRA CALCIUM STORAGE SITES
SMOOTH MUSCLE CONTRACTION at the MOLECULAR LEVEL
No sacromeres No troponin
Look inside the smooth muscle cell
Smooth Muscle Relaxation
Comparisons: Smooth versus Skeletal
Increase cytosolic calcium
Calcium binds calmodulin
Ca++Calmodulin activates MLCK
MLCK activates myosin ATPase
Shortening
Increase of cytosolic calcium
Calcium binds troponin
Alteration in troponin moves tropomyosin
Myosin binds actin
Shortening