2004 Alkaloids

AlkaloidsU 0600 Conicamin, a Novel Histamine Antagonist from the Mediterranean Tunicate

Aplidium conicum. — Together with two known alkaloids, the novel alkaloid coni-camin, (I), is isolated from the hydrophilic fractions of the methanolic extract of A. Conicum. Conicamin exhibits an antagonistic effect of a non-competitive type toward histamine receptors. This effect is observed in the micromolar range and seems to be specific. — (AIELLO, A.; BORRELLI, F.; CAPASSO, R.; FATTORUSSO*, E.; LUCIANO, P.; MENNA, M.; Bioorg. Med. Chem. Lett. 13 (2003) 24, 4481-4483; Dip. Chim. Sostanze Nat., Univ. "Federico II", I-80131 Napoli, Italy; Eng.) —H. Hoennerscheid

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