176 119 CONJUGATED OESTROGENS AND CLONIDINE: A NEW REGIMEN FOR THE TREATMENT OF POST-MENOPAUSAL WOMEN Adolf E. Schindler, D. Heners, Th. Pater and U. Wendel - TUbingen, F.R.G. The aim of the study was to investigate whether a reduced dose of oestrogen combined with clonidine would alleviate climactereic symptoms as effectively as higher doses of conjugated aestrogens. A controlled, randomized double-blind study was accordingly carried out in 83 patients complaining of post-menopausal symptoms. Treatment with a combination of 0.6 mg conjugated oestrogens and 1OOpg clonidine daily was compared with a daily dose of 1.25 mg conjugated oestrogens alone. The effect of these two regimens on the Kupperman index was evaluated after 2, ‘I, 8 and 12 weeks of therapy and a statistical evaluation of the results in 65 patients was performed. The number and intensity of hot flushes and sweats, as well as the severity of migraine headaches, improved on both regimens. There were no significant differences in either case. The combined treatment was judged by the patients to be significantly more effective (p<O.Ol) than oestrogen treatment alone. Side effects ‘were significantly fewer (p(O.01) during combination therapy than with oestrogens only. This study demonstrates that lower doses of oestrogens can be equally effective in the treatment of climacteric symptoms when combined with low-dose clonidine. Indeed, therapeutic efficacy was even improved and side effects reduced. Reduced doses of oestrogens in combination with clonidine therefore decrease the risk of oestrogen-dependent tumour development that is associated with long-term therapy.

Conjugated oestrogens and clonidine: a new regimen for the treatment of post-menopausal women

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176

119 CONJUGATED OESTROGENS AND CLONIDINE: A NEW REGIMEN FOR THE TREATMENT OF POST-MENOPAUSAL WOMEN

Adolf E. Schindler, D. Heners, Th. Pater and U. Wendel - TUbingen, F.R.G.

The aim of the study was to investigate whether a reduced dose of oestrogen combined with clonidine would alleviate climactereic symptoms as effectively as higher doses of conjugated aestrogens. A controlled, randomized double-blind

study was accordingly carried out in 83 patients complaining of post-menopausal symptoms.

Treatment with a combination of 0.6 mg conjugated oestrogens and 1OOpg clonidine daily was compared with a daily dose of 1.25 mg conjugated oestrogens alone. The effect of these two regimens on the Kupperman index was evaluated

after 2, ‘I, 8 and 12 weeks of therapy and a statistical evaluation of the results in 65 patients was performed.

The number and intensity of hot flushes and sweats, as well as the severity of

migraine headaches, improved on both regimens. There were no significant

differences in either case. The combined treatment was judged by the patients to be significantly more effective (p<O.Ol) than oestrogen treatment alone. Side effects ‘were significantly fewer (p(O.01) during combination therapy than with oestrogens only.

This study demonstrates that lower doses of oestrogens can be equally

effective in the treatment of climacteric symptoms when combined with low-dose clonidine. Indeed, therapeutic efficacy was even improved and side effects reduced. Reduced doses of oestrogens in combination with clonidine therefore decrease the risk of oestrogen-dependent tumour development that is associated with long-term therapy.