JOURNALOF HEPATOLOGYVOLUME 59, ISSUE 2, PAGES 201–402

FOCUS

FocusD. Shouval 201

EDITORIAL

Care coordination for patients with cirrhosis: A ‘‘win-win’’ solution for patients, caregivers, providers, andhealthcare expendituresP.S. Ge and B.A. Runyon 203

RESEARCH ARTICLES

Viral Hepatitis

Telaprevir can be successfully and safely used to treatolder patients with genotype 1b chronic hepatitis CN. Furusyo, E. Ogawa, M. Nakamuta, E. Kajiwara, H. Nomura, K. Dohmen,K. Takahashi, T. Satoh, K. Azuma, A. Kawano, Y. Tanabe, K. Kotoh,S. Shimoda, J. Hayashi and The Kyushu University Liver Disease Study(KULDS) Group 205

Does hepatitis C viremia or genotype predict the risk ofmortality in individuals co-infected with HIV?J.K. Rockstroh, L. Peters, D. Grint, V. Soriano, P. Reiss,A. d’Arminio Monforte, M. Beniowski, M.H. Losso, O. Kirk, B. Kupfer,A. Mocroft and for EuroSIDA in EuroCoord 213

Treatment optimization and prediction of HCV clearancein patients with acute HCV infectionA. Mangia, R. Santoro, M. Copetti, M. Massari, V. Piazzolla, E. Spada,G. Cappucci, G. Missale, L. Mottola, E. Agostinacchio, L. di Mauro,O. Zuccaro, P. Maio, F. Pellegrini, A. Folgori and C. Ferrari 221

Intrahepatic IL-8 producing Foxp3+CD4+ regulatory Tcells and fibrogenesis in chronic hepatitis CB. Langhans, B. Kramer, M. Louis, H.D. Nischalke, R. Huneburg,A. Staratschek-Jox, M. Odenthal, S. Manekeller, M. Schepke, J. Kalff,H.-P. Fischer, J.L. Schultze and U. Spengler 229

Cirrhosis

The Enhanced Liver Fibrosis (ELF) score: Normal values,influence factors and proposed cut-off valuesR. Lichtinghagen, D. Pietsch, H. Bantel, M.P. Manns, K. Brand andM.J. Bahr 236

Increased risk of cognitive impairment in cirrhoticpatients with bacterial infectionsM. Merli, C. Lucidi, I. Pentassuglio, V. Giannelli, M. Giusto, V. Di Gregorio,C. Pasquale, S. Nardelli, B. Lattanzi, M. Venditti and O. Riggio 243

The diagnostic accuracy of Fibroscan� for cirrhosis isinfluenced by liver morphometry in HCV patients with asustained virological responseR. D’Ambrosio, A. Aghemo, M. Fraquelli, M.G. Rumi, M.F. Donato, V. Paradis,P. Bedossa and M. Colombo 251

How to improve care in outpatients with cirrhosis andascites: A new model of care coordination by consultanthepatologistsF. Morando, G. Maresio, S. Piano, S. Fasolato, M. Cavallin, A. Romano,S. Rosi, E. Gola, A.C. Frigo, M. Stanco, C. Destro, G. Rupolo, D. Mantoan,A. Gatta and P. Angeli 257

Evidence that low protein C contributes to the procoa-gulant imbalance in cirrhosisA. Tripodi, M. Primignani, L. Lemma, V. Chantarangkul and P.M. Mannucci

265

Transplantation

Imaging of hepatitis C virus infection in liver grafts afterliver transplantationL. Mensa, S. Perez-del-Pulgar, G. Crespo, G. Koutsoudakis,C. Fernandez-Carrillo, M. Coto-Llerena, R. Miquel, H. Allende, L. Castells,M. Navasa and X. Forns 271

How to decide about liver transplantation in patients withhepatocellular carcinoma: Size and number of lesions orresponse to TACE?G. Otto, M. Schuchmann, M. Hoppe-Lotichius, M. Heise, A. Weinmann,T. Hansen and M.P. Pitton 279

Liver Failure and Growth

Hepatitis B virus HBx protein impairs liver regenerationthrough enhanced expression of IL-6 in transgenic miceI. Quetier, N. Brezillon, M. Duriez, H. Massinet, E. Giang, J. Ahodantin,C. Lamant, M.-N. Brunelle, P. Soussan and D. Kremsdorf 285

Cancer

Lysophosphatidylcholine acyltransferase 1 alteredphospholipid composition and regulated hepatomaprogressionY. Morita, T. Sakaguchi, K. Ikegami, N. Goto-Inoue, T. Hayasaka, V.T. Hang,H. Tanaka, T. Harada, Y. Shibasaki, A. Suzuki, K. Fukumoto, K. Inaba,M. Murakami, M. Setou and H. Konno 292

Cost-effectiveness of hepatic resection versus percuta-neous radiofrequency ablation for early hepatocellularcarcinomaA. Cucchetti, F. Piscaglia, M. Cescon, A. Colecchia, G. Ercolani, L. Bolondiand A.D. Pinna 300

Molecular and Cell Biology

Deficiency of insulin-like growth factor 1 attenuatesaging-induced changes in hepatic function: Role ofautophagyX. Xu, L.K. Hueckstaedt and J. Ren 308

Pathogenesis of FOLFOX induced sinusoidal obstructionsyndrome in a murine chemotherapy modelS.M. Robinson, J. Mann, A. Vasilaki, J. Mathers, A.D. Burt, F. Oakley,S.A. White and D.A. Mann 318

Cholestasis and Autoimmune Diseases

A validated clinical tool for the prediction of varices inPBC: The Newcastle Varices in PBC ScoreI. Patanwala, P. McMeekin, R. Walters, G. Mells, G. Alexander, J. Newton,H. Shah, C. Coltescu, G.M. Hirschfield, M. Hudson and D. Jones 327

Genetic and Metabolic Diseases

Arylacetamide deacetylase: A novel host factor withimportant roles in the lipolysis of cellular triacylglycerolstores, VLDL assembly and HCV productionM. Nourbakhsh, D.N. Douglas, C.H. Pu, J.T. Lewis, T. Kawahara, L.F. Lisboa,E. Wei, S. Asthana, A.D. Quiroga, L.M.J. Law, C. Chen, W.R. Addison,R. Nelson, M. Houghton, R. Lehner and N.M. Kneteman 336

Marked 25-hydroxyvitamin D deficiency is associatedwith poor prognosis in patients with alcoholic liverdiseaseE. Trepo, R. Ouziel, P. Pradat, Y. Momozawa, E. Quertinmont, C. Gervy,T. Gustot, D. Degre, V. Vercruysse, P. Deltenre, L. Verset, B. Gulbis,D. Franchimont, J. Deviere, A. Lemmers and C. Moreno 344

Sleep duration and quality in relation to non-alcoholicfatty liver disease in middle-aged workers and theirspousesC.-W. Kim, K.E. Yun, H.-S. Jung, Y. Chang, E.-S. Choi, M.-J. Kwon, E.-H. Lee,E.J. Woo, N.H. Kim, H. Shin and S. Ryu 351

REVIEWS

Established and new-generation antithrombotic drugs inpatients with cirrhosis – Possibilities and caveatsT. Lisman, P.W. Kamphuisen, P.G. Northup and R.J. Porte 358

Pulmonary contraindications, indications and MELDexceptions for liver transplantation: A contemporaryview and look forwardM.J. Krowka, R.H. Wiesner and J.K. Heimbach 367

NS5A inhibitors in the treatment of hepatitis CJ.-M. Pawlotsky 375

SPECIAL SECTIONS

International Hepatology

Reversion of hepatic stellate cell to a quiescentphenotype: From myth to reality?A. Mallat and S. Lotersztajn 383

Hepatology Snapshots

Alcohol and toxicityI. Rusyn and R. Bataller 387

Autophagy in the liverP. Codogno and A.J. Meijer 389

Clinical Application of Basic Science

Rethinking future development of molecular therapies inhepatocellular carcinoma: A bottom-up approachA. Villanueva 392

LETTERS TO THE EDITOR

SLC40A1-R178G or R178Q and ferroportin disease? Acall for vigilance in mutation reportingD.F. Wallace 396

Reply to: ‘‘SLC40A1-R178G or R178Q and ferroportindisease? A call for vigilance in mutation reporting’’M. Speletas, A. Kioumi and A.E. Germenis 397

The autophagic response to alcohol toxicity: The missinglayerN. Eid, Y. Ito and Y. Otsuki 398

Reply to: ‘‘The autophagic response to alcohol toxicity:The missing layer’’I. Rusyn and R. Bataller 399

Mother-to-infant transmission of hepatitis B virus infec-tion: Significance of maternal viral load and strategies forinterventionK.W. Cheung, M.T.Y. Seto and C.P. Lee 400

Reply to: Mother-to-infant transmission of hepatitis Bvirus infection: Significance of maternal viral load andstrategies for interventionW.-H. Wen, M.-H. Chang and H.-L. Chen 401

ERRATUM

Erratum to: ‘‘Digital image analysis of collagen assess-ment of progression of fibrosis in recurrent HCV afterliver transplantation’’ [J Hepatol 2013;58:962–968]P. Manousou, A.K. Burroughs, E. Tsochatzis, G. Isgro, A. Hall, A. Green,V. Calvaruso, G.L. Ma, J. Gale, G. Burgess, J. O’Beirne, D. Patch,D. Thorburn, G. Leandro and A.P. Dhillon 402

Registration of Clinical Trials

The Journal of Hepatology endorses the policy of the WHO and the International Committee of Medical Journal Editors (ICMJE) on the

registration of clinical trials. Therefore, any trial that starts recruiting on or after July 1, 2005 should be registered in a publicly owned, publicly

accessible registry and should satisfy a minimal standard dataset. Trials that started recruiting before that date will be considered for publication

if registered before September 13, 2005.

More detailed information regarding clinical trials and registration can be found in New Engl J Med 2004; 351:1250 1251 and New Engl J Med2005; 352:24372438.

Cover image: Autophagy in the Liver – Hepatology Snapshot by Codogno P. and Meijer A.J. (pages 389–391) and paper by Xu X. et al. (pages308–317), in this issue.