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Controlled Release Society
3355thth AAnnnnuuaall MMeeeettiinngg aanndd
EExxppoossiittiioonn ooff tthhee CCoonnttrroolllleedd RReelleeaassee SSoocciieettyy
22000088
July 12-16, 2008
New York, New York, USA
Volume 1 of 3
Printed from e-media with permission by:
Curran Associates, Inc. 57 Morehouse Lane
Red Hook, NY 12571 www.proceedings.com
ISBN: 978-1-60560-635-4
Some format issues inherent in the e-media version may also appear in this print version.
http://www.proceedings.com/
Copyright© (2008) by the Controlled Release Society. All rights reserved. For permission requests, please contact the Controlled Release Society at the address below. Controlled Release Society 3340 Pilot Knob Road St. Paul, Minnesota 55121
TABLE OF CONTENTS
Volume 1
Distinct Pharmacokinetic Performance of Biodegradable Microspheres of Hydrophilic Cefazolin with Different Release Characteristics ....................................................... 1
T. Zhu, J. Hong, J. Shah, D. Chow
Investigation of Rivastigmine Transport Through Human Colon Carsinoma Cells, Caco-2 .................................................................................................................................................. 3
B. Mutlu, Z. Degim, S. Yilmaz, D. Essiz, L. Altintas, G. Gunkaya
Design of the Semi-permeable Membrane for an Osmotic Drug Delivery System ...................... 5J. Yuan, N. Clipse, D. Dunn, R. Newton
Effects of Nano-hydroxyappatite on Poly (Lactide-co-Glycolide) Degradation as an In-situ Forming Implant ................................................................................................................. 7
M. Enayati, H. Mobedi, H. Mirzadeh, S. Hojjati-Emami
Formulation Optimization of a Controlled-Release Matrix System Utilizing Design of Experiment ...................................................................................................................................... 9
F-Y. Lin, F-H. Hsiao, Y-C. Changchien
Synergistic and Antagonistic Effects of Drugs and Ionic Salts on the Morphology and Functionality of the Gel Layer in HPMC Hydrophilic Matrices ............................................. 11
S. Pygall, P. Timmins, C. Melia
Translating Technology to Improve Global Health........................................................................ 13N. Bailey
Physicochemical Characterisation of a Solid Dispersion Containing a Poorly Water-soluble API ............................................................................................................................. 15
Y. Turner, C. Roberts, M. Davies, I. Weuts, S. Stokbroekx, F. Van Dycke, R. Leemans
Is Particle Size a Decisive Parameter for Nanoparticle Clearance from the Airways? ............................................................................................................................................ 17
A. Henning, M. Schneider, M. Bur, C-M. Lehr
Comparative Study of MPC and PEG for Protein Conjugation .................................................... 19A. Lewis, Y. Tang, S. Brocchini, J. Choi, A. Godwin
Drug Eluting Beads in the Treatment of Peritoneal Carcinomatosis .......................................... 21A. Lewis, C. Heaysman, Y. Tang, M. Keese, J. Lohr
Drug Eluting Beads in the Treatment of Glioma ............................................................................ 23A. Lewis, S. Baltes, T. Brinker
Preservation of the Active Lactone Form of Irinotecan Using Drug Eluting Beads .................. 25Y. Tang, P. Czuczman, S. Chung, A. Lewis
Anti-obesity Agents Based on Galegine......................................................................................... 27G. Coxon, S. Fogarty, B. Furman, D. Hardie, A. Harvey, S. Hawley, M. Mooney, R. Waigh
Develop a Methodology for an in Vitro-in Vivo Correlation (IVIVC) Model of Propranolol Extended-release Matrix Formulations ..................................................................... 29
H-L. Lee, Y-J. Lee, Y.H. Tsai, P-C Wu
PEG Microparticles Loaded with Diazepam Obtained by Particles from Gas Saturation Solution Technique: Production, Characterization and in Vitro Dissolution......................................................................................................................................... 31
I. Pasquali, L. Pezzini, R. Menabeni, R. Bettini
Biocompatibility and Biodegradation of PEG-based Fumarate Hydrogels for Gene delivery: in Vivo Studies ........................................................................................................ 33
M. Dadsetan, S. Ameenuddin, B. Currier, A. Windebank, M. Yaszemski
Bcl-2 Expression As a Proxy Redox Stimulus to Modulate Activity of Redox-sensitive Polyplexes ......................................................................................................................... 35
D. Manickam, D. Putt, S. Banerjee, F. Sarkar, L. Lash, D. Oupicky
Peg Based Micelles As Triggered System for Selective Targeting of Drugs.............................. 37S. Salmaso, F. Mastrotto, P. Caliceti
Polymeric Micelles for Amphotericin-B Delivery: A Comparative Study .................................... 39S. Salmaso, A. Brossa, S. Bersani, P. Caliceti
Thermosensitive Polymer Decorated Gold Nanoparticles As Switchable Delivery Systems ............................................................................................................................................. 41
S. Salmaso, P. Caliceti, V. Amendola, M. Meneghetti, G. Pasparakis, C. Alexander
Encapsulation and Release of an Insect Repellent (DEET) from a Starch-oil Microemulsion................................................................................................................................... 43
J. Wille, R. Toronyi
In Vitro Wound Healing Model for Drug Delivery Studies Into Sutured Surgical Incision............................................................................................................................................... 45
P. Kasha, C. Anderson, D. Ostrow, H-W. Hui, A. Banga
Nanoparticle with a Therapeutic Antisense Inhibit Restenosis in Rabbit Carotid Model .................................................................................................................................................. 47
J. Yang, Y. Zeng, Y. Li, C. Song
A Veterinary Delivery Odyssey - turned into a Story of Success by means of IVIVC ................................................................................................................................................... 49
C. Schmidt
Preliminary Evaluation of Glibenclamide Suppositories Based on Solidified Reverse Micellar Solution (SRMS) .................................................................................................. 51
A. Attama, O. Uchechi
Use of Carbohydrates in the Development of Synthetic Vaccines .............................................. 53P. Simerska, A-B. Abdel-Aal, Y. Fujita, W. Zhong, M. Batzloff, M. Good, I. Toth
Embryonic Stem Cells and Other Pluripotent Stem Cells as Versatile Tools for Biology, Cell Therapy and Drug Discovery .................................................................................... 55
N. Nakatsuji
PEGylated Oligonucleotide Duplexes and Their Self-assemblies with Polyamidoamine Dendrimers .......................................................................................................... 56
M. Elsabahy, M. Zhang, S-M. Gan, K. Waldron, J.C. Leroux
Leukotriene B4-loaded Microspheres: a New Therapeutic Strategy to Regulate Cell Activation ................................................................................................................................... 58
R. Nicolete, C. Rius, L. Piqueras, P-J. Jose, M-J. Sanz, L-H. Faccioli
Synthesis of Galactose-Poly(-caprolactone) and in Vivo Pharmacokinetic Study .................... 60W-J. Lin, K-L. Chang
Self-Assembling Hydrogels Formed by Beta-Cyclodextrin/Cholesterol Interactions ........................................................................................................................................ 62
F. van de. Manakker, M. van der. Pot, T. Vermonden, C. Van Nostrum, W. Hennink
Ligand-Targeted Delivery of Therapeutic and Imaging Agents to Pathologic Cells and Tissues ....................................................................................................................................... 64
S. Kularatne, W. Xia, W. Ayala-Lopez, B. Varghese, C-P. Leamon, I. Vlahov, C. Paulos
Evaluation of Recombinant Lysine-Histidine-FGF2 Analogues for Targeted Gene Transfer .............................................................................................................................................. 66
B. Canine, Y. Wang, A. Hatefi
Peritoneal Macrophage Depletion by Liposomal Alendronate Inhibits Implant Growth, Adhesions and Macrophage Infiltration in a Rat Model of Endometriosis .................. 68
E. Haber, N. Koroukhov, M. Schaghter, G. Golomb
Targeting Breast Cancer Cells via HER-2-mediated Endocytosis ............................................... 70S-C. Wuang, K-G. Neoh, E-T. Kang, D. Pack, D-E. Leckband
Tunable Delayed Release of Proteins with Polymer-Inorganic Composite Microspheres ..................................................................................................................................... 72
P. Pitukmanorom, J-Y. Ying
Cow Milk as Nutraceutical and Functional Food: Effect of Homogenization and Skimming on Lipid Globules Size Distribution .............................................................................. 74
M. Faustini, M. Bucco, A. Riccardi, C. Colombani, T. Chlapanidas, U. Conte, M. Torre, D. Vigo
Enhancing Dissolution of Poorly Water Soluble Drugs: Co-milling of Indomethacin and Ranitidine HCl Binary Mixtures ....................................................................... 76
N. Chieng, J. Aaltonen, D. Saville, T. Rades
Biorecognition of Lectin-immobilized Fluorescent Nanospheres with Surface Poly(N-vinylacetamide) Chains, against Various Human Colorectal Cancer Cells ................... 78
S. Sakuma, K. Hiwatari, T. Yano, Y. Masaoka, M. Kataoka, H. Tachikawa, Y. Shoji, R. Kimura, S. Yamashita
Exploring Changes in Early Gel Layer Formation and Drug Release from HPMC Matrices in the Presence of Dietary Sugars ................................................................................... 80
H.D. Williams, I.J. Hardy, R. Ward, C. Melia
Intestinal Absorption of Nanoparticulate Delivery System for Insulin........................................ 82B. Sarmento, D. Ferreira
The Interplay of Drug, Polymer, and Solvent Properties in the Release Characteristics of Phase Inversion ................................................................................................. 84
A-J. Mchugh, D. Ma
Permeation Enhancing and Mucoadhesive Properties of Chitosan-thioglycolic Acid Conjugates................................................................................................................................ 86
G. Perera, M. Greindl, A. Bernkop-Schnurch
Monodisperse Hydrogel Microparticles based on Crosslinked Hyperbranched Polyglycerol ....................................................................................................................................... 88
M. Oudshoorn, R. Penterman, R. Rissmann, J. Bouwstra, D-J. Broer, W. Hennink
Polymer-Drug Conjugates as Inhibitors of Cellular Apoptosis.................................................... 90M.J. Vincent, L. Mondragon, M. Orzaez, L. Dieudonne, A. Moure, A. Arminan, P. Sepulveda, L. Pen, I. Goicoechea, A. Alcaraz, A. Messeguer, E. Perez-Paya
Three Dimensional Co-culture of Nucleus Pulposus Cells and Adipose Stromal Vascular Fraction .............................................................................................................................. 92
T. Chlapanidas, P. Gaetani, F. Crovato, F. Caviggioli, M. Bucco, M. Faustini, P. Pisano, D. Levi, D. Vigo, M. Klinger, M. Marazzi, M. Torre
Adipose-derived Stem Cells for Regenerative Medicine: Yield of Stromal Vascular Fraction from Liposuction or Lumbar Resection .......................................................................... 94
M. Bucco, F. Caviggioli, P. Gaetani, F. Crovato, M. Faustini, T. Chlapanidas, V. Sansone, P. Pisano, D. Vigo, M. Marazzi, M. Klinger, M. Torre
Essential Fatty Acid Required for Healthy Skin............................................................................. 96P. Wertz
Development of a Biomimetic Vector for Targeted Gene Transfer.............................................. 98Y. Wang, B. Canine, A. Hatefi
Inventive Academics Can Make New Pharmaceuticals for Global Use..................................... 100S. Shaunak
Monitoring Sustained-release Film Coating Quality and Dissolution Using ............................ 101L. Ho, R. Muller, K. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P. Taday, J. Zeitler
Development of Novel Amphotericin B loaded Environment Sensitive Micelles for Treatment of Systemic.................................................................................................................... 103
T. Diezi, Y. Bae, G. Kwon
Pharmacokinetics of p(NIPAM-co-MAA-co-Acrylamide) as Excipients in Drug Delivery ............................................................................................................................................ 105
N. Bertrand, J.C. Leroux
Nanocarrier based on Polyelectrolyte Multilayers for Photodynamic Therapy........................ 107M. Schneider, N. Reum, K. Low, A. Wiehe, H. Briesen, C. Lehr
Liposomal Vasoactive Intestinal Peptide for Lung Application: Protection from Proteolytic Degradation.................................................................................................................. 109
B. Stark, F. Andreae, R. Prassl
Preparation and Evaluation of Paclitaxel/OK432-Eluting Silicone/Polyurethane Membrane for Bile Duct Stent........................................................................................................ 111
S.S. Hong, M. Kim, S. Jeong, J.H. Maeng, D. Lee
Investigating the Precorneal Residence Time of Ophthalmic In-situ Gelling Systems Using Gamma Scintigraphy ........................................................................................... 113
I.D. Rupenthal, C.R. Green, I.M. Hassan, M. Rutland, R. Alany
Antisense Oligonucleotide Loaded In-situ Gelling Systems for Improvement of the Corneal Wound Healing After Refractive Surgery ................................................................ 115
I.D. Rupenthal, C.R. Green, R. Alany
Thiolated Polycarbophil as an Adjuvant for Permeation Enhancement ................................... 117A. Vetter, R. Martien, A. Bernkop-Schnurch
Assessment of Suitability of Solid Lipid Nanoparticles (SLN) for Incorporation of Miconazole ....................................................................................................................................... 119
A. Silva, D. Santos, D. Ferreira, E. Souto
Bridging Polymer Chemistry, Polymer Physics, Biology and Medicine to Design Injectable.......................................................................................................................................... 121
P. Zawaneh, S. Singh, J. Spector, D. Putnam
Yeast-based Delivery System and Its Release Triggers ............................................................. 123G. Dardelle, V. Normand
Targeted Photothermal Ablation Effect of Hollow Gold Nanoshells in Tumor-bearing Mice .................................................................................................................................... 125
W. Lu, C. Xiong, G. Zhang, Q. Huang, R. Zhang, Z. Cheng, C. Li
Brain Cancer Therapy in Rats Using Tumor-suppressor Peptide, p53p-Ant............................ 127D. Kaneko, T. Ozeki , H. Okada
A Polymer Blend System for Lower Intestine-targeted Drug Delivery ...................................... 129T. Omura, M. Tauchi, Y. Inoue, M. Haratake
Adipose Stromal Vascular Fraction from Knee Hoffa's Body as Feed-Layer........................... 131F. Crovato, F. Mingotto, M. Bucco, T. Chlapanidas, F. Caviggioli, P. Gaetani, M. Faustini, D. Vigo, M. Klinger, M. Marazzi, M. Torre, V. Sansone
Analysis of Human Growth Hormone Structure Following Encapsulation Using Supercritical CO2............................................................................................................................. 133
C. Kelly, A. Lewis, A. Naylor, T. Gamble, L. Romero, P. Van Hooff, C. Upton, M. Whitaker, S. Howdle
Poly (ethyleneimine) Nanoprobes for Magnetic Resonance and Multiple Molecular Imaging ............................................................................................................................................ 135
M.A. Do, H. Lee, E. Oh, J.H. Yeum, H. Ghim, K. Jeon, H. Chung, Y. Jang, J. Choi
A Fast/slow Biphasic Delivery System for Ibuprofen Release ................................................... 137C. Lopes, P. Costa, J. Pinto, J.M. Lobo
Intranasal Delivery of Insulin Using a Microemulsion System .................................................. 139S. Botner, H. Levy, A. Sintov
pH-responsive Hydrogel for Delivery of VEGF ............................................................................ 141J. Garbern, P. Stayton, A. Hoffman
Microemulsion-based Nanoparticles Loaded with Insulin ......................................................... 143A. Graf, K. Jack, A. Whittaker, S. Hook, T. Rades
Human Fat as a Scaffold Material for Tissue Engineering ......................................................... 145J. Choi, H. Yang, Y. Park, Y. Yun, Y. Cho, H. Lee
The Influence of Degree of Esterification on In Situ Gelling Pectin Formulations .................. 147S. Miyazaki, K. Itoh, A. Takahashi, D. Attwood
Oligonuleotide Delivery into Liver using Dendritic Poly (L-lysine) ........................................... 149T. Niidome, Y. Sugao, K. Watanabe, T. Mori, Y. Katayama
Electrospun Core-sheath Ultrafine Fibers as Carriers for Protein Delivery System ............... 151Y. Yang, X. Li
Star-like Antibody-Targeted Polymer-Drug Conjugates ............................................................. 152T. Etrych, L. Kovar, M. Sirova, B. Rihova, K. Ulbrich
Improving Oral Bioavailability of Somatostatin Cylic Peptide Analogs by Multiple N-Methylation .................................................................................................................................. 154
O. Ovadia, E. Biron, J. Chatterjee, C. Gilon, H. Kessler, A. Hoffman
Structural Modifications Related to Temperature and Medium Influence in Vivo Efficiency of Amphiphilic ............................................................................................................... 156
C. Roques, K. Bouchemal, G. Ponchel, Y. Fromes, E. Fattal
In Vitro-In Vivo Correlation of Controlled Release HPMC Matrix Tablets: A Gamma Scintigraphic Study ........................................................................................................................ 158
M. Ghimire, S.M. Connolly, L.A. Hodges, J. Band, B. O'Mahony, A. Stanley, F. Mcinnes, A. Mullen, H. Stevens
Phospholipid – Decorated Microcapsules Used As Ultrasound Contrast Agent..................... 160R. Diaz-Lopez, N. Tsapis, V. Nicolas, D. Libong, P. Chaminade, E. Fattal
Solubilization and Release Patterns of Sodium Diclofenac into Monoolein/Ethanol/Water Delivery Systems ................................................................................ 162
R. Efrat, A. Aserin, N. Garti
Optimized Lipid Transfer Method for the Preparation of asymmetrical Membrane Vesicles ............................................................................................................................................ 164
M. Holzer, J. Momm, R. Schubert
Influence of Pharmaceutical Surfactants as Modulators of the Efflux Transporter P-glycoprotein ................................................................................................................................. 166
M. Leonhardt, U. Adam, S. Nagel, W. Weitschies
Cyclosporine Solid Lipid Nanoparticles: Evaluation of In-vivo Drug Release in Rabbit Eyes...................................................................................................................................... 168
E. Gokce, G. Sandri, S. Egrilmez, M. Bonferoni, T. Guneri, C. Caramella
Preparation and Characterization of Ibuprofen Self-Emulsified Drug Delivery System (IBSEDDS) to Enhance Solubility and Dissolution ........................................................ 170
A. Zaghloul, A. Nada, I. Khattab, S. Al-Saidan
Preparation, Characterization, and Aerosolisation Studies Of Optimized Poly (D, L- Lactide) Microspheres for Pulmonary Delivery ........................................................ 172
X. Song, P. Seville, Y. Perrie
Active Targeting of Liposomes with the B-chain of Mistletoe Lectin I...................................... 174V. Bunjes, K. Winkler, R. Peschka-Suess, R. Schubert
COHOGM – A novel Membrane Anchor Molecule for the Preparation of Membrane Skeleton Liposomes ....................................................................................................................... 176
C. Zimmer, E. Breitling, M. Muller, A. Neub, R. Schubert
Dodecaborate Cluster Lipids in Liposome Preparations for Use in Boron Neutron Capture Therapy.............................................................................................................................. 178
A. Burghardt, T. Schaffran, D. Gabel, R. Peschka-Suess, R. Schubert
Development and Scale-Up Considerations for Novel Solvent Free Injection Molding Delivery Systems ............................................................................................................. 180
S.P. Li, D. Lee, D. Wynn, H. Sowden, F. Bunick, G. Mcnally
Formulation Development of Nano-Liposomes for Sustained and Targeted Dermal Delivery ............................................................................................................................... 182
M. Madan, A. Bajaj, N. Amrutiya
Synthesis of a Novel Fluorescent Transglutaminase Inhibitor for Controlled Release from Catheters and Other Implant Devices ................................................................... 184
N. Daneshpour, R. Colligan, Y. Perrie, A. Mongeot, D. Rathbone, P. Lambert, M. Griffin
Introducing a Novel Thiolated Chitosan ....................................................................................... 186G. Millotti, H. Hoyer, A. Bernkop-Schnurch
Transferrin Coupled Liposomes for Brain Targeting of 5-Florouracil....................................... 188A. Jain, V. soni, S. Jain
Increased Intestinal Permeability Induced by the Antimicrobial ............................................... 190S. Maher, X. Wang, V. Bzik, S. Mclean, D. Brayden
Comparison of Three in Vitro Intestinal Mucosa Diffusion Systems ........................................ 192V. Bzik, D. Brayden
Influence of the Hydration Kinetics and the Viscosity Balance on the Drug Release Performance of Push-pull Osmotic Systems ................................................................ 194
V. Malaterre, H. Metz, J. Ogorka, K. Mader, R. Gurny, N. Loggia
A Pharmacoscintigraphic Study to Assess the Performance of Novel Gastroretentive................................................................................................................................ 196
V.E. Cowles, S.Y.E. Hou, R. Fell, T. Gordi, R. Gu, P. Evans, A. Church, A. Connor, I. Wilding, B. Berner
Delivery of Foreign Antigen Vaccines by Recombinant Outer Membrane Vesicles ................ 198D. Chen, S. Metzger, N. Osterrieder, D. Putnam
Bio-inspired Symmetrical Lipids for Controlled Drug Delivery.................................................. 200S. Yazdi, D. Putnam
In Vivo Delivery of anti-kITENIN siRNA Complexed with Biodegradable PEI-alt-PEG Suppressed Colon Carcinorma Established Subcutaneously in Mice ............................. 202
K. Kim, D. Jere, C.S. Cho, I. Chung
Investigation of the Effect of Microsphere Size and PLGA Molecular Weight on the Internal pH of Degrading PLGA Microspheres ...................................................................... 204
K. Stovall, D. Pack
Synthesis and Characterization of Hyperbranched Poly (amido amine)s for Gene Delivery ............................................................................................................................................ 206
Y.Z. You, J. Chen, D. Manickam, Q.H. Zhou, L. Wan, G. Mao, D. Oupicky
In Vivo Whole Body Imaging with a New Lipid Core Micelle-based Near Infrared Imaging Agent ................................................................................................................................. 208
A. Papaqiannaros, A. Kale, D. Chovatia, T. Levchenko, W. Hartner, D. Mongayt, V. Torchilin
JNK1 as a Molecular Target to Limit Cellular Damage Under Hypoxia ..................................... 210S. Betigeri, O. Garbuzenko, T. Minko
Hyaluronic Acid-Paclitaxel Conjugate Micelles: Synthesis, Characterization, and Anti-tumor Activity.......................................................................................................................... 212
H. Lee, T. Park
Development of an Anti-thrombogenic Drug Eluting Stent: Combinational Drug Approach ......................................................................................................................................... 214
K. Vedantham, I.K. Kwon, S. Kim, K. Park
Molecular Weight Effect and Potential as a Gene Carrier of Chitosan Oligosaccharides and Low Molecular Weight Water Soluble Chitosan.................................... 216
M.K. Jang, D. Kim, J.W. Nah
Reducible r9 Polyplex Enhances Gene Expression .................................................................... 218Y.W. Won, S.J. Lee, M.H. Lee, Y. Kim
All-Trans Retinoic Acid Release from Ion Complex Polymeric Micelles of Methoxy Poly (Ethylene Glycol)-Grafted-Chitosan ..................................................................................... 220
M.K. Jang, D. Kim, C.N. Jeong, Y. Park, J.W. Nah
Design of Magnetic Resonance Imaging Contrast Agent for Angiogenic Therapy ................. 222J.I. Jo, L. Xue, I. Aoki, Y. Tabata
A Novel Functional Scaffold Combined with Controlled Release of Bone Morphogenetic Protein Enhances Stem Cell-based Regeneration After Radiation Therapy: an Experimental Study in Rabbits................................................................................. 224
M. Yamamoto, A.Hokugo, Y. Takahashi, Y. Tabata
Preparation of Sustained Release Granules containing Highly Water Soluble Drug and Evaluation of Tolerance to Mechanical Stress in Gastrointestinal Tract .......................... 226
Y. Yaqinuma, N. Yoshida
Rapid Screening of Drug Release and Penetration into Stratum Corneum Membrane ........................................................................................................................................ 228
E. Stelmach, J. Lenn, V. Wirth, R. Buchta, H. Hofland
Receptor Targeted Polymers, Dendrimers, Liposomes: Which Nanocarrier is the Most Effective For Tumor Specific Treatment and Imaging?..................................................... 230
M. Saad, O. Garbuzenko, E. Ber, P. Chandna, J. Khandare, V. Pozharov, T. Minko
Evaluation of Phototoxicity Induced by Hydroxycinnamic Acid Upon UVA Exposure .......................................................................................................................................... 232
P. Batheja, R. Sivalenka, P. Wu, N. Dayan, B. Michniak
In Vivo Delivery of Bio-nanocapsules Displaying L4-PHA Isolectin to Malignant Tumors Overexpressing N-Acetylglucosaminyltransferase V ................................................... 234
T. Kasuya, J. Jung, H. Kadoya, T. Matsuzaki, K. Tatematsu, T. Okajima, E. Miyoshi, K. Tanizawa, S. Kuroda
Influence of Size, Charge, Shape, and Route of Liposomes Administration on Their Cellular Uptake, Tumor and Organ Distribution in Mice ................................................... 236
O. Garbuzenko, M. Zhang, M. Saad, S. Betigeri, E. Ber, T. Minko
Formulation Development Intended for Increasing Compliance and Improving the Hardness and the Friability of Tablets Containing Valacyclovir................................................ 238
H.G. Shin, H.C. Chang, M.S. Lee, S. Choi
Delivery of Interleukin 18-encoding Plasmid DNA to Lung Cancer Cells using Cationic Emulsion........................................................................................................................... 240
H. Kang, S.J. Jin, J.K. Kim, S. Hwang, J.S. Park
Development and in Vitro Evaluation of Novel Gastroretentive Sustained Release Tablet Formulation of Norfloxacin ................................................................................................ 242
P.D. Mair, N.S. Kulkami, N.S. Ranpise, M.V. Gaikwad
Improved Dermal Delivery of Lipophilic Agents from Nanoparticle Encapsulated Emulsions ........................................................................................................................................ 244
N. Eskandar, S. Simovic, C. Prestidge
pH-Responsive Anionic Hydrogel Microparticles for Intelligent Drug Delivery System ............................................................................................................................................. 246
Y. Shin, S. Lee, K. Kim, W. Ryoo, B. Kim
Pharmacokinetic and Pharmacodynamic Study of Biadhesive Transdermal Formulation ..................................................................................................................................... 248
S. Amin, S. Mir, K. Kohli, R. Khar, K. Pillai
Preparation and Properties of Inhalable Nanocomposite Particles for Treatment of Lung Cancer................................................................................................................................ 250
K. Tomoda, K. Hirota, H. Terada, T. Nakajima, G. Sonavane, K. Makino
Gene Transcription is Regulated by the Motility of DNA Strand, but not by Extent of DNA Compaction ........................................................................................................................ 252
Y. Katayama, Y. Sato, K. Terada, T. Niidome, T. Mori
Microspheres for Controlled Release of Biopharmaceuticals Prepared via S/O/W Emulsion .......................................................................................................................................... 254
Y. Kakizawa, J. Michizoe, R. Nishio, M. Koiwa, M. Nukiwa, N. Ida
Comparison of In-vitro, In-vivo Data by Different Granulation Method in a Matrix Controlled-Release System ........................................................................................................... 256
Y.L. Wang, W.T. Huang, Y.C. Changchien
Development of a Transdermal Patch of Pentazocine: In Vitro Evaluation Across Hairless Mouse Skin ....................................................................................................................... 258
T. Furuishi, T. Io, T. Fukami, T. Suzuki, K. Tomono
Sustained Release with Ibuprofen Eluting Microspheres: in Vivo Quantification with Infrared Microspectroscopy .................................................................................................. 260
J.Namur, M. Wassef, J.P. Pelage, A. Lewis, M. Manfait, A. Laurent
Nerve Conduits Releasing Two Different Neurotrophic Factors ............................................... 262S. Madduri, M. Papaloizos, B. Gander
Improved Absorption of Salmon Calcitonin from Rat Small Intestine in Vivo with Sodium Caprate and a Mucolytic (n-acetyl-cysteine).................................................................. 264
X. Wang, M. Tambuwala, D. Brayden
Immobilized Trypsin for in Vivo Detection of Gastric A1-antitrypsin ........................................ 266E. Khazanov, N. Emmanuel, A. Azab, E. Yavin, Y. Barenholz, A. Rubinstein
Doxorubicin Eluting Beads for Liver Embolisation: Pathological Findings and Correlation with Drug Distribution in Tissue ............................................................................... 268
J. Namur, M. Wassef, J.M. Millot, A. Lewis, M. Manfait, A. Laurent
Controlled Release Formulation of Tamsulosin HCl using EUDRAMODETM Technology ...................................................................................................................................... 270
S. Mohite, A. Samel, S. Bodinge, H. Ravishankar, B. Broegmann, U. Loeffler, K. Glaenzer
Effects of Unfocused Shock Wave Stimulation on Human Microvascular Endothelial Cell Line HMEC-1 ........................................................................................................ 272
M.C. D'Agostino, C. Bonora, E. Ungaro, M. Faustini, T. Chlapanidas, F. Crovato, M. Bucco, D. Vigo, P. Gaetani, M. Marazzi, M. Klinger, V. Sansone, M. Torre
Influence of the Components of Polymer Film on Mechanical Properties Influence of the Components of Polymer Film on Mechanical Properties ................................................ 274
R. Tunio, W. Sawicki
The Effect of Simulated Intestinal Fluid on the Stability and Efficacy of a Novel Cyclodextrin Gene Delivery Vector ............................................................................................... 276
M. O'Neil, M. Walsh, C. Byrne, R. Darcy, C. O'Driscoll
Enhanced Drug Skin Penetration and Intracellular Delivery for Topical Basal Cell Carcinoma Therapy......................................................................................................................... 278
D. Ainbinder, E. Touitou
Investigation of the Absorption Enhancing Effect of Ethanol in Rats ...................................... 280X. Wang, M. Tambuwala, D. Brayden
Buspirone Transdermal Delivery in Rats from Ethosomes ........................................................ 282M. Shumilov, E. Touitou
Transferrin Appended Long Circulating Nanoparticles for Brain Targeting ............................ 284A. Jain, S. Jain
Synergistic UV Protection Efficacy of NLC Loaded with Ternary Sunscreen Mixture ............................................................................................................................................. 286
M. Joshi, S. Nikolic, R.H. Muller
Physicochemical Characteristic of Lyophilized Coenzyme Q10 Nanocrystals........................ 288R. Mauludin, A. Hommoss, J. Knauer, R.H. Muller
Dissolution Velocity of Coenzyme Q10 Nanocrystal-Loaded Capsules ................................... 290R. Mauludin, S. Kobierski, J. Knauer, R.H. Muller
Ultrasound: An Effective Tool for Controlling the Release of Drugs from PEGylated Liposomes .................................................................................................................... 292
A. Schroeder, R. Honen, M. Brandl, A. Gabizon, Y. Barenholz, J. Kost
Microsphere-Adjuvant Combinations to Improve Tuberculosis Vaccine Efficacy .................. 294D. Kirby, V. Bramwell, Y. Perrie
Enhanced Delivery of Doxorubicin to Cancer Cells Via Folate Coupled Liposomes .............. 296Y. Gupta, A. Jain, S. Jain
Tween 80 Affects the Released Rate of Lipid-based Microemulsion with Entrapped Curcumin....................................................................................................................... 298
H.Y. Lin, J. Thomas, C.C. Lin, H.C. Chen, M.H. Lee
Human Plasma Levels of Quercetin Following Oral Administration ......................................... 300D. Kaushik, K. O'Fallon, P. Clarkson, B. Michniak-Kohn
Automated Controlled Release Multiple Layer Coating.............................................................. 302D. Chinta, R. Graves, S. Pamujula, T. Mandal
Pegylated PLGA Nanoparticles for Cellular Drug Delivery......................................................... 304S. Pamujula, S. Hazari, G. Bolden, R. Graves, D. Chinta, S. Dash, V. Kishore, T. Mandal
Engineered Nanoparticles Using High Pressure Homogenization ............................................ 306R. Graves, S. Pamujula, D. Chinta, L. Bostanian, T. Mandal
Enteric HPMC Capsules: Formulation and in Vitro Performance .............................................. 308A. Smith, Y. Perrie
Stability of BCG Loaded Alginate Beads...................................................................................... 310A. Smith, H. Batchelor, Y. Perrie
Sodium Alginate Drug Delivery Films........................................................................................... 312S. Skulason, T. Kristmundsdottir, J. Thrainsson
Role of a Novel Excipient Poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in Delivery of Lysozyme from PLGA Microspheres .................................... 314
A. Taluja, Y. Bae
Formulation and Stability Aspects of Gas-Filled Liposomes: An Effective Aid To Extract Earth’s Oil?......................................................................................................................... 316
A. Vangala, R. Morris, M. Bencsik, Y. Perrie
Controlled Release Formulation of Liposomal Tea Tree Oil ...................................................... 318U. Bhujbal, M. Kenward, C. Martin
Development of Glucose Oxidase Encapsulated Microspheres against Multidrug Resistant Breast Cancer Cells ....................................................................................................... 320
J. Cheng, Q. Liu, A. Rauth, X. Wu
P.L.E.A.S.E.®: a Promising Tool for Intraepidermal Drug Delivery ........................................... 322Y.G. Bachhav, S. Summer, A. Heinrich, T. Bragagna, C. Bohler, Y.N. Kalia
Effect of Epidermal and Dermal Tissue on Triptorelin Stability in Solution and the Impact of P.L.E.A.S.E.® Treatment on Its Permeation Kinetics Across Porcine Skin in Vitro ..................................................................................................................................... 324
Y.G. Bachhav, S. Summer, A. Heinrich, T. Bragagna, C. Bohler, Y.N. Kalia
Trans-ungual Iontophoretic Delivery of Terbinafine Hydrochloride.......................................... 326A.B. Nair, H. Kim, P. Friden, J. Singh, M. Zaman, A. Gupta, S.N. Murthy
Taste Masking of Sodium Chloride in Beverages Using Nanolipidic Particle Technology ...................................................................................................................................... 328
M. Fountain, K.M. Miller, S.F. Staggs, G.M. Santalucia, G. Delaportas
Influence of Voltage Application on Electrophoretic Transdermal Delivery of Fentanyl ........................................................................................................................................... 330
B. Schroder, E. Meyer, U. Nickel, G. Lee
Effect of Particle Size of Mannitol on Polymethacrylate Matrices Prepared by Direct Compression ........................................................................................................................ 332
L. Chatteriee, A.K. Baier, T. Rades, I. Tucker
Characterisation, Swelling and Release from Liquid Crystalline Systems of Phytantriol and Glycerylmonooleate As Platforms for Controlled Release of Bioactives ........................................................................................................................................ 334
S.B. Rizwan, B.J. Boyd, T. Rades, S. Hook
In-vitro Activity of Phytantriol Cubosomes Containing the Adjuvants Imiquimod or Monophosphoryl Lipid A in Bone Marrow Derived Dendritic Cells ...................................... 336
S.B. Rizwan, W. McBurney, B.J. Boyd, T. Rades, S. Hook
In Vivo Investigation of a Thermosensitive Chitosan Hydrogel as a Sustained Release Vaccine Delivery System ................................................................................................. 338
S. Gordon, A. Saupe, W. McBurney, T. Hennessy, T. Rades, S. Hook
In Vitro Transdermal Delivery of Penbutolol Sulfate ................................................................... 340K. Ita, A. Banga
Thermo-sensitive Radiopaque Copolymers for Embolization ................................................... 342B. Lee, C. Leon, M. Preul, B. Vernon
Direct Detection of Absolute Protein Content and Drug Release of Plga-nanoparticles by Spectrophotometry and Fluorimetry............................................................... 344
M. Holzer, T. Pisternick, V. Vogel, K. Langer
Novel Combination of Monocaprin and Doxycycline in Treatment of Cold Sores................... 346S. Skulason, T. Kristmundsdottir, W.P. Holbrook, H. Thormar
Enhanced Targeted Tumorotoxicity and Reduced Cardiotoxicity with Bispecific Antibody-Polymer-Prodrug Complexes: In Vitro Studies with BT-20 Human Breast Carcinoma and Embryonic Cardiocytes....................................................................................... 348
K. Gada, V. Patil, B.A. Khaw
Evaluation of Therapeutic Efficacy and Adriamycin Distribution Encapsulated in Polymeric Micelles by Convection-enhanced Delivery............................................................... 350
M. Nishihara, T. Inoue, Y. Yamashita, S. Sugiyama, Y. Sonoda, T. Kumabe, T. Tominaga, M. Yokoyama
Development of a Recombinant Non-viral Vector for Targeted Breast Cancer Gene Therapy .................................................................................................................................. 352
S.S. Mangipudi, A. Hatefi
Research and Development Focuses on Drug-eluting Stents in Post-LST Era ....................... 354J.Z. Zhao
siRNA Delivery to the Metastatic Tumor....................................................................................... 355S. Li, S. Chono, L. Huang
In Vitro Determination of Gastrointestinal Mucoadhesion Formulations ................................. 357S. Jang, J.T. McConville
Effect of Tapping Massage using Micro-Fibers on Transdermal Delivery................................ 359E. An, J. Shim, J. Lee, Y. Kim, B. Kim, J. Kim
Use of Capmul MCM as a Skin Penetration Enhancer: Influence of Capmul Concentration and Vehicle............................................................................................................. 361
L. Lopes, A. Nornoo
Development of a Canine Gastric Emptying Model for Evaluation of Prokinetic Agents .............................................................................................................................................. 363
L.A. Hodges, F. McInnes, V. Lewis, E. Engmann, W. Speed, N.J. Clear, C.G. Wilson, H. Stevens
Responsiveness of Glial Cells to Metallic Nanoparticles ........................................................... 365D. Maysinger
Ultrasonic Disruption of Pluronic F127 Coated Liposomes ....................................................... 367M.H. Lee, S.Y. Yang, J. Thomas, H.Y. Lin
Organoleptically Appealing Immediate Release EUDRAGIT® Coatings................................... 369A. Samel, P. Haksar, J. Iyer-Chavan, H. Ravishankar, T. Morita
Preparation and Characterization of Liposomes Coated with Thiolated Poly (acrylic Acid) for Oral Drug Delivery ............................................................................................. 371
M. Werle, H. Takeuchi
Preparation and Characterization of Drug-in-Adhesive Type Patches Containing Meloxicam ........................................................................................................................................ 373
Y. Ah, Y. Choi, J. Choi, H. Kim, J. Bae
Characterization of Acyclovir Skin Depot Following Iontophoretic Delivery in Vivo .............. 375S. Siddoju, P. Friden, A. Banga
Poly (epsilon-caprolactone)-Polyglycidol Hyperbranched Conjugates .................................... 377L. Wang, X. Li, C. Song
Formulation and Evaluation of Liposomal Drug Delivery System for L-Asparaginase................................................................................................................................... 379
M. Senthil, D. Venkatesh, K. Gowthmarajan, M.K. Samanta, B. Suresh
Comparison of Molecular Weight, Intrinsic Viscosity, Zeta Potential and Antibacterial Activities of Five Alkylated Chitosan Derivatives................................................. 381
A.M.M. Sadeghi, M.X. Weinhold, M.R. Avadi, M. Rafiee-Tehrani, H. Junginger
Generation of CTLs Capable of Targeting and Injuring Tumor Vessels for Adoptive Immunotherapy............................................................................................................... 383
N. Kanagawa, T. Yanagawa, Y. Mukai, Y. Yoshioka, N. Okada, S. Nakagawa
Anti-CD20 – Hpma Copolymer Conjugate Radiopharmaceuticals ............................................ 385V. Subr, M. Hruby, K. Kynclova, L. Kronrad, K. Ulbrich
Design and Evaluation of Drug-in-Adhesive Fentanyl Transdermal Bioequivalent Therapeutic System ........................................................................................................................ 387
G. Goyal, P. Vavia
A Novel Spermine-based Reductable Carrier for Gene Expression and Silencing Studies in Lung Cancer .................................................................................................................. 389
D. Jere, J.E. Kim, M.H. Cho, C.S. Cho
Surface Plasma Resonance Analysis for Binding Affinity Assessment of Anti-VEGF 2’-OMe-RNA Aptamer before and after PEGylation .......................................................... 391
K. Kim, H. Kang, E. Oh, J.K. Park, S. Hahn
Polypeptide-based Polymersomes as Biomimetic Nano-carriers ............................................. 393W. Agut, C. Sanson, D. Taton, A. Soum, C. Schatz, J.F. Le Meins, S. Lecommandoux
HIV-Tat Analog-modified Mpeg-PCL Diblock Copolymeric Nanoparticles As a Non-viral Gene Vector .................................................................................................................... 395
T. Kanazawa, Y. Shibata, K. Sakurai, Y. Takashima, H. Okada
Target Specific Intracellular Delivery of siRNA Complexed with PEI-HA Conjugate............... 397S. Hahn, G. Jiang, K. Park, J. Kim, K. Kim
Supramolecular Control of pDNA Delivery to Cell Nuclei and Translation: Efficacy of Amine Groups on Biocleavable Polyrotaxanes....................................................................... 399
A. Yamashita, D. Kanada, R. Katoono, N. Yui, T. Ooya, A. Maruyama, H. Akita, H. Harashima
Carrier-based Radiochemotherapy ............................................................................................... 401T. Lammers, V. Subr, K. Ulbrich, P. Peschke, F. Kiessling, P. Huber, W. Hennink, G. Storm
Camptothecin-loaded Solid Lipid Nanoparticles for Brain Delivery.......................................... 403S. Martins, D. Ferreira, E. Souto, M. Brandl
Biodistribution Study of Nanoparticle-bound Rifabutin ............................................................. 405S. Gelperina, A. Bud'ko, O. Maksimenko, L. Vanchugova, E. Shipulo, A. Ivanov, J. Kreuter
Transcutaneous Immunization with Diphtheria Toxoid-loaded Elastic Vesicle Formulations following................................................................................................................... 407
Z. Ding, S. Romejin, H. Hirschberg, G. Kersten, M. Bivas-Benita, W. Jiskoot, J. Bouwstra
Accurate GI targeting with EUDRAGIT® FS 30 D / L 30 D - 55 mixtures ................................... 409M. Assmus, T. Dassinger, G. Galayo, B. Skalsky
Some HPMA Conjugates do not Need Calreticulin to Evoke Anti-tumor Resistance ....................................................................................................................................... 411
L. Kovar, T. Etrych, J. Strohalm, D. Plocova, K. Ulbrich, B. Rihova
Controlled Iontophoretic Delivery of 5-OH-DPAT for the Treatment of Parkinson’s Disease............................................................................................................................................. 413
O. Ackaert, J. Van Smeden, J. De Graan, D. Dijkstra, M. Danhof, J. Bouwstra
Co-iontophoresis of Dexamethasone Sodium Phosphate, Granisetron and Metoclopramide for Treating Chemotherapy Induced Nausea and Vomiting .......................... 415
J. Cazares-Delgadillo, A. Ganem-Rondero, D. Quintanar-Guerrero, Y.N. Kalia
The Effect of HPMA Drug Based Therapy on the Local Tumor Microenvironment ................. 417O. Hovorka, D. Vetvicka, R. Joskova, E. Baumgartnerova, K. Ulbrich, B. Rihova
Depot Formulation of Vasoactive Intestinal Peptide by Protamine-Oligonucleotide Nanoparticles .................................................................................................................................. 419
K. Wernig, M. Griesbacher, F. Andreae, W. Mosgoeller, J. Wagner, A. Zimmer
Iontophoretic Delivery of Dexamethasone Sodium Phosphate Across Porcine Skin in Vitro ..................................................................................................................................... 421
J. Cazares-Delgadillo, A. Ganem-Rondero, D. Quintanar-Guerrero, Y.N. Kalia
Gamma Sterilisation of Non-Viral Transfection Agents.............................................................. 423S. McNeil, A. Mohammed, Y. Perrie
In Vivo Comparison of the Inhibitory Effect of Thiolated Poly (acrylic Acid) of Various Molecular Masses and Various Concentrations on Intestinal MRP2 Efflux Pumps .............................................................................................................................................. 425
J. Hombach, M. Greindl, A. Bernkop-Schnurch
Synthesis and In Vitro Characterization of a Novel Poly (acrylic acid)-4-Aminothiophenol Conjugate .......................................................................................................... 427
D. Sakloetsakun, H. Hoyer, A. Bernkop-Schnurch
Studies on Insitu Hydrogel – A Smart Way for Safe and Sustained Ocular Drug Delivery ............................................................................................................................................ 429
D. Shastri, L.D. Patel
Self-assembly of Recombinant Oligopeptide Into Vesicles ....................................................... 431A. Van Hell, W. Jiskoot, D. Crommelin, W. Hennink, E. Mastrobattista
Co-encapsulation of Proteins and Magnetic Particles in Biocompatible Polymer Nanoparticles .................................................................................................................................. 433
J.D. Garza, C. Schatz, S. Lecommandoux
Nanosizing Indomethacin by Wet Ball-Milling Technique – An Efficient Method to Improve the Solubility Properties of the Poorly Soluble NSAID ................................................ 435
R. Kettunen, L. Peltonen, M. Karjalainen, J. Hirvonen
Effect of Water Soluble Carriers on the Dissolution and Physical Stability of Meloxicam Solid dispersions......................................................................................................... 437
L. Emara, R. Badr
Preparation and Evaluation of Nanosuspensions from Thiolated Polymers via High Pressure Homogenization..................................................................................................... 439
W. Schlocker, H. Hoyer, A. Bernkop-Schnurch
Modification of the Tumor Microenvironment by a Plasmid Encoding an Antiangiogenic Factor .................................................................................................................... 441
N. Crokart, N. Goncalves, L. Daugimont, F. Danhier, B. Ucacar, B. Jordan, V. Gregoire, O. Feron, B. Gallez, V. Preat
Simple and Reproducible Ion-pair HPLC Assay for Determination of SN-38 in Nanoparticles .................................................................................................................................. 443
P. Ebrahimnejad, F. Atyabi, A. Sajadi, M.R. Jaafari, R. Dinarvand
Preparation and Characterization of a Poly Lactide-co-glycolydes .......................................... 445P. Ebrahimnejad, S. Sajadi, M.R. Jafari, F. Atyabi, F. Ramezani, R. Dinarvand
Analysis of Drug Pharmacokinetics and Pharmacodynamics by PET Imaging: Novel Method for the Development of Nanocarrier-related Drugs ............................................ 446
Y. Katayama, T. Urakami, S. Akira, A. Kawaguchi, N. Harada, H. Ysukada, N. Oku
Development of Nano-sized PICsomes and Evaluation of Their Properties ............................ 448Y. Anraku, A. Kishimura, Y. Yamasaki, K. Kataoka
Engineering Electrospun Silk Scaffolds with Dual Drug Gradients .......................................... 450A. Wandrey, V. Vogel, H. Merkle, L. Meinel
Flow Cytometry for Counting, Sizing and Sorting of Nanoparticles in Biological Fluids................................................................................................................................................ 452
E. Van Gaal, R. Hulikunta, W. Hennink, D. Crommelin
Enhanced Intestinal Delivery and Stability Both in Vivo and in Vitro of Site Specific PEGylation of Salmon Calcitonin to Different Molecular Sizes of Polypeg®.......................................................................................................................................... 454
S. Ryan, X. Wang, G. Mantovani, D. Haddleton, D. Brayden
Anti-tumor Immunity in Mice Following the Treatment with HPMA-based Copolymer Conjugate of Doxorubicin .......................................................................................... 456
M. Sirova, J. Strohalm, V. Subr, D. Plocova, K. Ulbrich, B. Rihova
Polymer-Coiled-Coil Therapeutics as Molecular Switches: Towards New Treatments for the Zaire Ebola Virus ............................................................................................ 458
S. Deacon, B. Apostolovic, H.A. Klok, R. Duncan
Intracellular Delivery of Doxorubicin to Tumor Cells Through the M6P/IGFII Receptor: a Novel Strategy to Target Cancer Cells..................................................................... 460
J. Prakash, A. Harapanahalli, M. Zeinstra-Smith, L. Beljaars, K. Poelstra
Determination of Drug Release and Distribution from Drug-eluting Stents Employing a Novel Dissolution Test Method ............................................................................... 462
A. Neubert, S. Nagel, K. Stemberg, W. Weitschies
Polymer Microsphere Particle Standards Containing High Explosives .................................... 464M. Staymates, R. Fletcher, J. Verkouteren, J. Coleman, C. Berkland, G. Gillen
Alginate Based Beads for Controlled Release of Levobupivacaine Base ................................ 466C. Blackshields, E. Conway, A. Crean
Ex vivo Evaluation of Natural and Methylated Cyclodextrins as Buccal Permeation Enhancers for Omeprazole Delivery ........................................................................ 468
A. Figueiras, J. Hombach, F. Veiga, A. Bernkop-Schnurch
Effect of Nanoparticle Characteristics on Interaction with Endothelial Model Cell Membrane ........................................................................................................................................ 470
C. Peetla, V. Labhasetwar
Enhancing the Intracellular Release of siRNA with Biodegradable Poly (Ethylene Imine) as Carrier System ................................................................................................................ 472
M. Breunig, C. Hozsa, U. Lungwitz, A. Goepferich
Smart Hybrid Magnetic Self-Assembled Polymer Vesicles ........................................................ 474S. Lecommandoux, O. Sandre, R. Perzynski
pH-Responsive Micelles and Vesicles Based on Polypeptide Diblock Copolymers ............... 476S. Lecommandoux, F. Checot, J. Babin
Development of a Novel Caco-2 based 3D model of the Inflamed Intestinal Mucosa: Initiation of Inflammation................................................................................................ 478
F. Leonard, E.M. Collnot, C. Lehr
Biopharmaceutical Characterisation of Melt-Extrudates Using the Caco-2-Cell-Model: Cytotoxicity and Permeability Screening ........................................................................ 480
J. Kanzer, I. Tho, M. Degenhardt, M. Magelein, G. Fricker, M. Brandl
Long Circulating Biodegradable Polymeric Micelles: Towards Targeted Drug Delivery ............................................................................................................................................ 482
C. Rijcken, R. Schiffelers, C. Van Nostrum, W. Hennink
Amino Acid-based Organogelators for the Preparation of Injectable Implants ....................... 484G. Bastiat, A. Vintiloiu, J.C. Leroux
Effect of Ethanol as a Co-Solvent on the Characteristics of PLGA Microspheres .................. 486A. Rawat, U. Bhardwaj, D. Burgess
Permeation of Benzocaine Across Pig Ear Skin from Bioadhesive Films................................ 488D.R. De Aranjo, C. Padula, P. Santi
Mixed Immunomicelles for Delivery of Poorly Soluble Anticancer Drugs: Improved Solubilization and In Vitro Cytotoxicity....................................................................... 490
R. Sawant, V. Torchilin
Next Generation Targeting: Multifunctionalized Nanoparticles for Enhanced Cancer Chemotherapy.................................................................................................................... 492
Y. Patil, J. Panyam
Experimental and Theoretical Investigation of Corneocyte-drug Interactions: Effect of Hydration on Stratum Corneum Partitioning of Caffeine ............................................ 494
S. Hansen, A. Nagel, M. Heisig, G. Wittum, D. Neumann, C. Lehr, U. Schafer
Polyelectrolyte Complexed Nanoparticles Deliver Insulin for Oral Dosage Form ................... 496C. Woitski, R. Neufeld, A. Ribeiro, F. Veiga
The Architecture of Ligand Attachment to Nanocarriers Controls Their Interaction with Target Cells ............................................................................................................................. 498
R. Sawant, R. Sawant, A. Kale, V. Torchilin
Cytotoxic Effect of Methotrexate-Loaded Microemulsion on Human Breast, Ovarian and Prostate Carcinoma Cell Lines ................................................................................ 500
H.Y. Karasulu, G. Kantarci, B. Karaca, T. Guneri
Paclitaxel pH-sensitive Liposomes and Its Action on B16F10 Melanoma Cells ...................... 502H. Karanth, R. Gude, R.S.R. Murthy
Enhancement of the Intestinal Absorption of Orlistat, a Lipophilic Drug with Anticancerous Properties, by Using Lipid-based Systems........................................................ 504
P. Houer, M. Guhmann, J. Correia, T. Vandamme
A Novel PEG-chelating Agent Conjugate for Protein Delivery................................................... 506G. Pasut, A. Mero, T. Ishino, I. Chaiken, M. Sergi, F. Veronese
Targeted Nanomedicines Delivering siRNA Potentiation of Silencing Activity by Photochemical Internalization ....................................................................................................... 508
R. Schiffelers, S. Oliveira, M. Woddle, A. Hogset, G. Storm
Epirubicine-PEG-folate Conjugates: the Effects of Folic Acid and Folic Acid / Polymer Ratio on Conjugates Cytotoxicity and Cellular Uptake ............................................... 510
F. Canal, G. Pasut, M.J. Vincent, F. Veronese, O. Schiavon
Efficient siRNA Delivery Using Water Soluble Lipopolymer for Anti-angiogenic Gene Therapy .................................................................................................................................. 512
W. Kim, C.W. Chang, M. Lee, S. Kim
Investigating the Impact of Humidity on Drug - Propellant Interactions for Metered Dose Inhaler Systems..................................................................................................................... 514
P. Jannick, F. Thielmann, M. Naden, D. Burnett
Chitosan Systems for Acyclovir Controlled Release .................................................................. 516R. Ruiz, T. Marras, M. Saiz, M. Veiga
Mucoadhesive Hydrogel Films Based on Blends of Poly (Acrylic Acid) and Methylcellulose for Buccal Drug Delivery .................................................................................... 518
O. Khutoryanskaya, V. Khutoryanskiy, M. Naderi, D. Burnett
High-Throughput Study on the Impact of Freeze-Drying Conditions on the Stability of Co-Lyophilized Protein-Saccharide Formulations ................................................... 520
K. Ward, I. Cook, F. Thielmann, D. Burnett
A Novel Micelle-like Nanoparticle (MNP) for In Vivo Gene Delivery .......................................... 521Y. Ko, A. Kale, L. Bhave, V. Torchilin
Fusion Studies of Charged Heterogeneous Membranes: Effect of pH and Cholesterol ...................................................................................................................................... 523
M. Bhagat, S. Sofou
TATp-bearing Immunoliposome for In Vivo Gene Delivery to Ischemic Myocardium ..................................................................................................................................... 525
Y. Ko, W. Hartner, L. Bhave, V. Torchilin
Volume 2
Preparation and Characterization of Insulin Loaded Polyanhydride Microspheres ................ 527
C. Manoharan, J. Singh
Intramuscular Gene Delivery Using Cationic Nanoparticles for Prevention of Type 1 Diabetes ........................................................................................................................................ 529
A. Basarkar, J. Singh
Development and Characterization of HER2-Specific Affibody-Conjugated Thermosensitive Liposomes for Improved Delivery of Therapeutic Agents to HER2-Positive Tumors ................................................................................................................... 531
A. Yavlovich, R. Campbell-Massa, S.B. Lee, G. Kramer-Marek, S. Tele, J. Capala, R. Blumenthal, A. Puri
β-Lapachone Micellar Nanotherapeutics for Lung Cancer Treatment ...................................... 533E. Blanco, E. Bey, D. Boothman, J. Gao
Influence of the Molecular Weight of Polyethylene Glycol on the Enteric Properties of Hard Shell Capsules ................................................................................................ 535
H. Bruce, V. Wolf, L. Felton
Effect of Particle Size on the Deposition of Magnetic Aerosol Particles .................................. 537Y. Xie, Y. Xu, J. Wang, B. Hammer, T. Wiedmann
PEG-PE Micelles with Novel Poorly-soluble Pro-apoptotic Agent: Activity in vivo................. 539I. Skidan, P. Dholakia, A. Degterev, V. Torchilin
Thermosensitive Injectable Implants: a Good Candidate for Long Term Controlled Delivery of Protein .......................................................................................................................... 541
Y. Tang, J. Singh
Evaluation of Sodium-deoxycholate Gels Containing Betamethasone-17-Valerate................ 543T. Senyigit, O. Ozer
Combination of Novel Pro-Apoptotic Agent DM-PIT-1 and TRAIL in the Same Micellar Preparation Provides Increased Cytotoxicity in both TRAIL-resistant and TRAIL-sensitive Cells ..................................................................................................................... 545
I. Skidan, A. Degterev, V. Torchilin
Pharmacokinetic Profile Modulation of a Poorly-Water Soluble Compound Using Poloxamers ...................................................................................................................................... 547
C. Popescu, O. Magnusson, J. Bjornsson, M. Thorsteinsdottir, J. Singh, M. Gurney
Photodynamic Therapy of B-16 Melanoma in Mice with Tumor-targeted meso-Tetraphenylporphin-loaded PEG-PE Micelles.............................................................................. 549
I. Skidan, P. Dholakia, V. Torchilin
Stability of Anti-Inflammatory Agents in Stealth Nanoparticles ................................................ 551X. Lu, M. Howard, J. Rinehart, M. Leggas, M. Jay
Synthesis and Characterization of Novel Starch-Xanthan Gum Hydrogels for Controlled Drug Delivery................................................................................................................ 553
A. Shalvin, Q. Liu, M. Abdekhoadie, X. Wu
Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell PLGEOF Nanoparticles .................................................................................................................................. 555
X. He, J. Ma, A. Mercado, W. Xu, E. Jabbari
Carbon Nanotubes as Drug Delivery Systems ............................................................................ 557I. Degim, X. Xu, A. Rawat, D. Burgess
In Vitro Permeation Studies of Novel Buprenorphine Prodrugs in Human Skin...................... 559S. Banks, D. Hammell, M. Golinski, J. Howard, A. Stinchcomb
Carbon Nanotubes (CNTs) for Enhancing Drug Transport Through Skin ................................ 561I. Deqim, S. Verma, F. Papadimitrakopoulos, D. Burgess
Low Residual Solvent Microparticle Formulations ..................................................................... 563D. Biggs, H. Nettles, G. Winchester, P. Markland
The Cleavage of HIV-I TATp in Human Plasma by Protease Activity ........................................ 565J. Grunwald, T. Rejtar, V. Torchilin
Respirable PLGA-Microspheres for Pulmonary Delivery of Hepatitis B Vaccine .................... 567C. Thomas, A. Rawat, F. Ahsan
Acrylic-Rubber Hybrid Polymer for Transdermal Drug Delivery ............................................... 569J. Ouyang, P. Foreman
Inhaled Cationic Liposomes of Low Molecular Weight Heparin in the Treatment of Venous Thromboembolism............................................................................................................ 571
S. Bai, F. Ahsan
Efficient Modulation of T Cell Response by Single Microparticle-mediated, Combinatorial Delivery of IL-10 Silencing siRNA and Plasmid DNA Vaccine .......................... 573
A. Singh, H. Nie, K. Roy
Degradation and Sustained Release from Injectable, Bioresorbable, Thermosensitive Copolymer, Poly (NIPAAm-co-dimethyl-γ-butyrolactone acrylate-co-acrylic Acid) ................................................................................................................ 575
Z. Cui, B. Lee, B. Lunt, B. Vernon
Polyethylene Glycol-phosphatidylethanolamine (PEG-PE) Micelles Loaded with Paclitaxel and Surface-modified with a Pro-apoptotic PBR-ligand for a Synergistic Anticancer Effect by Receptor-mediated Intracellular Drug Delivery ....................................... 577
T. Musacchio, A. Latrofa, G. Trapani, V.P. Torchilin
Poly (etherhydroxylamine) PEHAM Dendrimer Nanoparticles for Combination Therapy and Diagnostic ................................................................................................................. 579
S. Svenson, A. Chauhan, M. Zhuravel
New Formulation of Dual Agent Solid Polymer-Lipid Hybrid Nanoparticles: Exploitation of the Anti-Cancer Synergy of Doxorubicin and Mitomycin C against Multidrug Resistant Human Breast Cancer Cells ........................................................................ 581
A. Shuhendler, A. Connor, A. Rauth, X. Wu
Water-soluble Vitamins Loaded in Biodegradable Nanoparticles ............................................. 583M. Stevanovic, M. Jevtic, D. Uskokovic
Investigation of Different Lipid-Based Systems Designed To Enhance the Oral Bioavailability of Lipophilic Drugs ................................................................................................ 585
M. Guhmann, J. Correia, P. Houer, T. Vandamme
Chitosan/PEG Diblock Copolymer as a Thermosensitive Hydrogel.......................................... 587F. Ganji, M. Abdekhoadie
PGE1 Microparticles for the Treatment of Pulmonary Arterial Hypertension ........................... 589V. Gupta, A. Rawat, F. Ahsan
Hydrophilic Surface Characteristics of PEO-modified Silicone Gels ........................................ 591S. Sivas, N. Hoy, K. Reichel
Phage Coat Protein pVIII as a Novel Targeting Ligand for the Formulation of Tumor Targeted Pharmaceutical Nanocarriers............................................................................ 593
G.G.M. D'Souza, T. Wang, P.K. Jayanna, V.A. Petrenko, B.P. Stenberg, V.P. Torchilin
Surface Modification of Pharmaceutical Nanocarriers with Ascorbate Residues as a Novel Approach for Tumor Cell Targeting and Killing............................................................. 595
G.G.M. D'Souza, T. Wang, M. Toniutti, K. Rockwell, V.P. Torchilin
Screening of Particle Size Distribution Affecting Variables in a Rotating Pan Granulation Process Using a 27-3 Fractional Factorial Design ................................................... 597
J. Chan, S. Vogel, J. Wen, R. Alany
Study of the Release Mechanisms of the Diphacinone Granules for Controlled Release Delivery Using a Fractional Factorial Design ................................................................ 599
J. Chan, S. Vogel, R. Alany, J. Wen
Development of Organic Hydrogel Matrix Based Wound Dressing Containing Antibiotics........................................................................................................................................ 601
S. Jin, H.J. Park, J.K. Park, J. Kim, B. Cha, M. Yoo, H.G. Choi
Development of a Citric Acid - PEG Polyester Gel with Biodegradability and pH Responsive Drug Release .............................................................................................................. 603
K. Uchida, S. Sakata, H. Ooba, K. Sutani, M. Fujishima, K. Fuji
Preparation of Nano Complex of DA 6034, a New Drug Candidate for Gastritis and Evaluation of its Gastroprotective Effect ..................................................................................... 605
S. Jang, S. Han, J. Kim, B. Cha, M. Yoo, K. Lee
A Novel Targeted Proapoptotic Drug Delivery System for Efficient Anticancer Therapy ............................................................................................................................................ 607
P. Chanda, M. Saad, Y. Wang, E. Ber, J. Khandare, A. Vetcher, V. Soldatenkov, T. Minko
Internally Quaternized PAMAM-OH Dendrimers as Efficient siRNA Delivery Systems: the Effect of Targeting Moiety and Degree of Quaternization ................................... 609
M. Khang, M. Patil, O. Taratula, H. He, T. Minko
Toward in vivo Targeting Delivery of siRNA for Efficient Cancer Therapy............................... 611O. Taratula, P. Kirkpatrick, R. Savla, I. Pandya, T. Minko, H. He
Multifunctional siRNA Delivery System for Cancer Therapy...................................................... 613R. Savla, O. Taratula, I. Pandya, A. Wang, T. Minko, H. He
Novel Chinese Traditional Medicine Pellets Prepared by Extrusion-Spheronization Method .................................................................................................................. 615
W.H. Chuo, T.H. Wu, T.R. Tsai, Y.T. Huang, T.M. Cham
A Novel Nanostructured Oral Delivery System for Lipophilic Drugs ........................................ 617A. Tan, S. Simovic, A. Davey, T. Rades, C. Prestidge
Application of Melt Granulation Technology to Enhance Tabletting Properties of Poorly Compactible Drug Substance at High Dose .................................................................... 619
J. Lakshman, J. Kowalski, M. Vasanthavada, W.Q. Tong, A. Serajuddin, Y. Joshi
Can PECA Nanoparticles be used to Achieve a Biological Response to Sterility Agents for the Brushtail Possum?................................................................................................ 621
A. McDowell, A. Kafka, J. Crawford, D. Eckery, B. McLeod, T. Rades
Effect of pH and Glutathione on the Dissociation Kinetics of Redox Sensitive Polyplexes ....................................................................................................................................... 623
L. Jayanthi, A. Wani, D. Oupicky
New Shapes for Drug Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage ....................................................................... 625
S. Cai, T. Harada, T. Minko, D. Discher
Separable Dissolving Microneedles for Rapid Vaccine Delivery to Skin.................................. 627L. Chu, M. Prausnitz
Study on the Blend of Kollidon SR and Ibuprofen ...................................................................... 629G. Dorairaju, B. LaBrec, A. Listro, L. Acquarulo
Influence of Particle Size and Preparation Methods on the Physical and Chemical Stability of Amorphous Simvastatin ............................................................................................. 631
F. Zhang, J. Aaltonen, F. Tian, D. Saville, T. Rades
The Use of MALDI TOF Mass Spectrometry to Identify Co-polymerization in PACA Nanoparticles .................................................................................................................................. 633
A. Kafka, T. Kleffmann, T. Rades, A. McDowell
Liposomal Tissue Plasminogen Activator with Biological Half-life Enhancement .................. 635J.Y. Kim, E. Ban, Y. Choi, C.K. Kim
Novel Cationic Solid Lipid Nanoparticles Enhanced P53 Gene Transfer to Lung Cancer Cells .................................................................................................................................... 637
S. Choi, S. Jin, E. Ban, S. Kim, Y. Choi, C.K. Kim
Anticancer Activity and DDS Application of Green Tea Polyphenol Derivatives..................... 639K. Matsumura, K. Kaihatsu, S. Mori, S.H. Hvon
Formulation Development of Derris Emulsifiable Concentrate for Crop Pest Control.............................................................................................................................................. 641
A. Yoon, R. Wiwattanapatapee, J. Petcharat, C. Ovatlamporn, A. Itharat
Preparation and Functional Analyses of Water-dispersed Carbon Nanohorns for Cancer Chemotherapy.................................................................................................................... 643
T. Murakami, H. Sawada, M. Yudasaka, S. Lijima, K. Tsuchida
Targeted Delivery of SU5416 and Antiangiogenic Cancer Therapy Using Tumor Vasculature-targeted Liposomes .................................................................................................. 645
T. Ida, Y. Katanasaka, K. Shimizu, T. Asai, N. Maeda, K. Baba, N. Oku
Antineovascular Therapy by Using Dual-targeting Liposomes ................................................. 647Y. Murase, Y. Katanasaka, T. Asai, N. Maeda, T. Tanaka, N. Oku
Permeability Study of NNZ-2566 (an analogue of glycine-proline-glutamate, N-terminal tripeptide of insulin-like growth factor-I) Across a Human Intestinal Epithelium Cell Line (Caco-2) ........................................................................................................ 649
J. Wen, G. Thomas, D. Bachelor, P. Gluckman
Direct and Quantitative Measurement of Liquid Flow on a Microfluidic Chip .......................... 651C. Haber, U. Kanne
Simple Method for Preparation of Solid Lipid Nanoparticles With High Entrapment Efficiency of Hydrophilic Drugs ............................................................................... 653
R. Patil, P.V. Devarajan
Polymeric Micelles for MRI Contrast Agent, Tumor Targeting and Imaging by Magnetic Resonance Imaging ....................................................................................................... 655
K. Shiraishi, K. Kawano, T. Minowa, Y. Maitani, M. Yokoyama
Immunosuppressive Vaccine Via Transcutaneous Immunization............................................. 657N. Ohmori, T. Nakano, S. Goto, K.C. Chiang, Y. Shimada, K. Mori, T. Miyagi, S. Kawamoto, K. Ono, T. Goto, S. Sato
Preparation, Characterization, and Antidiabetic Potentials of Bile Acids Modified Exendin-4 ......................................................................................................................................... 659
S. Son, C.H. Jin, S. Chae, K. Lee
Surface Charge-modified PEG-liposomes for Enhancement of Cellular Uptake and Anti-tumor Activity .................................................................................................................. 661
H. Seong, S. Jung, S. Kim, S. Jung, D. Lim, E. Kim, S. Cho, B. Shin
Thermosensitive and Chemically Crosslinkable Poly (organophosphazene) Gels ................. 663T. Potta, S.C. Song
Transdermal Delivery Test of Maltose Microneedle into Human Skin ...................................... 665Y. Tobinaga, T. Kitagawa
Functionalized PLGA Foams for Controlled Gene Delivery: Influence of Surface Modification on Matrix-DNA Interaction ....................................................................................... 667
H. Nie, S. Khew, L. Lee, K. Poh, Y. Tong, C. Wang
Bi-phase Alginate Carriers for Controlled Release of BMP-2 .................................................... 669H. Lim, E. Oh, K. Jeon, H. Chung, J. Choi, H. Ghim
Development of Novel Vehicles for Topical Glucocorticoid Formulation: an in Vitro and in Vivo Evaluation .......................................................................................................... 671
J. Bae, K. Hong, S. Jeong, B.D. Park, S. Lee
Preparation of N-Isopropylacrylamide Hydrogel-Coated Gold Nanorods ................................ 673A. Shiotani, T. Kawano, T. Mori, Y. Niidome, Y. Katayama, T. Niidome
Functional Assessment of Polyplex Micelles with Cyclic RGD Peptide Ligands and Disulfide Crosslinked Core..................................................................................................... 675
M. Oba, K. Aoyagi, K. Miyata, N. Nishiyama, H. Koyama, K. Kataoka
Application of TNF-related Apoptosis-Inducing Ligand (TRAIL) for Rheumatoid Arthritis Therapy ............................................................................................................................. 677
C.H. Jin, S. Chae, E. Lee, H. Yoo, Y. Hong, K. Lee
PLGA/Chitosan Composites from a Combination of Spay Drying and Supercritical Fluid Foaming Techniques: New Carriers for Gene Delivery ..................................................... 679
H. Nie, L. Lee, H. Tong, C. Wang
Triblock Copolymer Micelles with Biocompatible, Endosomal Escaping, DNA-Condensing Functions for Systemic Gene Delivery ................................................................... 681
K. Miyata, M. Oba, M. Kano, S. Fukushima, N. Nishiyama, K. Miyazono, K. Kataoka
Methods for Producing Oral Aqueous Solution Containing Ubidecarenone ........................... 683S.M. Seo, J.B. Lee, S.B. La, H.k. Tan, S. Kim
Environmental Sensitivities of the Polyion Complex Vesicles (PICsomes) ............................. 685A. Kishimura, S. Liamsuwan, H. Oana, Y. Yamasaki, K. Kataoka
Measurement of Compaction Force and Displacement Parameters for Quantification of Compactability of Pharmaceuticals ................................................................ 687
S. Patel, A. Kaushal, A. Bansal
An Innovative Transcutaneous Vaccination System Using a Hydrogel Patch Formulation ..................................................................................................................................... 689
Y. Ishii, N. Okada, Y.S. Quan, F. Kamiyama, Y. Mukai, Y. Yoshioka, S. Nakagawa
Micro Mechanical Investigation of Fracture Properties of Roller Compacted Acetaminophen ............................................................................................................................... 691
S. Patel, A. Kaushal, A. Bansal
A Novel Sulfated Polysaccharide from Red Microalgae: Applications of Polysaccharide Gels ....................................................................................................................... 693
S. Arad
Amphiphilic Poly-N-vinylpyrrolidones as Alternative Coatings for Long-circulating Liposomes .................................................................................................................... 695
M. Shtilman, A. Kuskov, V. Torchilin, A. Tsatsakis
A Novel Gene Carrier Responding to Virus Protease ................................................................. 697M. Kuramoto, D. Asai, T. Mori, T. Niidome, H. Nakashima, Y. Katayama
Novel Transdermal Delivery System Using the Water Vapor Controllable Fabrics ................. 699K. Hong, H.J. Park, S. Jeong, B.D. Park
The Use of Reconstructed Human Epidermis for the Evaluation of the Skin Irritation Potential of PX-13 and PX-18 Nanosuspension ........................................................... 701
J. Pardeike, R. Muller
Fabrication of Micro-Patterned Surfaces by Polymer Inkjet Printing........................................ 703J. Kim, Y. Yun, B. Lee, Y. Cho
The Effects of Manufacturing Process on the Wet Granules for ODTs..................................... 705J. Wang, H. Lim, K. Kim, S. Park, G. Seomoon, S. Hwang, H. Chung, C. Pai, K. Park
Tolerability Evaluation of PX-13 and PX-18 in Primary Human Fibroblasts and Keratinocytes Monolayer Cell Cultures ........................................................................................ 707
J. Pardeike, R. Muller
Effects and Mechanisms of Luteolin on Modulation of Multidrug Resistance and Induction of Apoptosis in Caco-2 Cells ........................................................................................ 709
Y.L. Lo, R.L. Ran, C.T. Ho
Primary Porcine Alveolar Epithelial Cells (pAEpC) as a Model for Drug Permeability Assays ....................................................................................................................... 711
H. Eixarch, A. Steimer, E. Haltner-Ukomadu, U. Bock
Efficiency and Skin Irritation Potential of Solid Lipid Nanoparticles (SLN) and Dendritic Core-Multishell Nanocarriers ........................................................................................ 713
S. Kuchler, M. Radowski, R. Haag, M. Schafer-Korting
Improvement of Dissolution from Tablets Made by Compression of Solid Dispersions...................................................................................................................................... 715
T. Hoshino, F. Tanno
Effect of Immunization to Ovalbumin Administrated by Biocompatible Microneedle Sheets ........................................................................................................................ 716
H.H. Park, M. Han, S. Lee, S. Kim, C.W. Cho, D. Hyun, C. Kim, C.G. Kim
Freeze-dried Chitosan-hyaluronic Nanoparticles as Vehicles for DNA Delivery ..................... 718A. Vila, M. De La Fuente, M. Alonso
Development of Angiogenic Vessel-targeted Polycation Liposomes for Delivering Small Interfering RNA ..................................................................................................................... 720
S. Matsushita, T. Asai, Y. Suzuki, T. Ishida, N. Maeda, T. Dewa, H. Kiwada, M. Nango, N. Oku
Effect of Polymer and its Molecular Weight on the in vitro Cytotoxicity of Ribonuclease Conjugates .............................................................................................................. 722
B. Treethammathurot, E. Ferguson, L. Diuedonne, D. Schmaljohann, R. Wiwattanapatapee, R. Duncan
Dissolution Media Dependent Susceptibility of Dosage Forms to Biorelevant Mechanical Stress........................................................................................................................... 724
G. Garbacz, W. Weitschies
Oligomer Chitosan Nanocapsules for Targeted Delivery of Docetaxel in Cancer Cells.................................................................................................................................................. 726
M.V. Lozano, D. Torrecilla, D. Torres, A. Vidal, M.J. Alonso, F. Dominguez
A Liposomal Drug Delivery System for Targeting the Brain ...................................................... 728H.F. Liang, Y.C. Chen, L.W. Chang, Y.C. Lo, M. Lo
Nanocarriers for Gene Silencing in Vitro, in Situ and in Vivo .................................................... 730B. Pitard, C. Gourden, E. Letrou-Bonneval, R. Chevre, R. Labas
Particle Tailoring for User-Friendly Inhalation Devices .............................................................. 732K. Kawakami, C. Sumitani, Y. Uchida, Y. Yoshihashi, E. Yonemochi, K. Terada
Effect of Methods for Applying of the Polymer Microneedle-Roller on the Permeation of L-Ascorbic Acid in Rats ........................................................................................ 734
C.W. Cho, S.K. Yu, H.H. Park, M. Han, S. Lee, D. Hyun, C.H. Kim
Inorganic Apatite-liposome Complex: Novel Hybrid Carrier for mRNA Based Gene Delivery ............................................................................................................................................ 736
F. Zohra, E. Chowdhury, T. Akaike
The Role of a Lipophilic Adjuvant to Produce High Respirable Tobramycin Powders for Inhalation ................................................................................................................... 738
C. Parlati, R. Bettini, F. Sonvico, P. Colombo, F. Buttini