Caring For People In Pain

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Deltaclav(Amoxicillin / Clavulanate potassium)

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Antibiotic Use and Resistance

• Strong epidemiological evidence that antibiotic use in humans and animals associated with increasing resistance.

• Sub therapeutic dosing encourages resistant mutants to emerge; conversely, rapid bactericidal activity discourages.

• Presence of b-lactamase producing organisms.• Abuse of the usage of antibiotics.• Defective patient compliance.

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DELTACLAVDELTACLAV (Amoxicillin / Clavulanate potassium)

It was produced originally to reduce the development of drug-resistant bacteria.DELTACLAV is supplied in the new recommended concentrations ratios

228.5457

Ratio of 1:7

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DESCRIPTION:

DELTACLAV is an oral antibacterial combination consisting of the semi-synthetic antibiotic amoxicillin and the lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid).

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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After oral administration of single doses: Peak concentrations occurred approximately 1 hour after the dose.Approximately 50% to 70% of the amoxicillin and approximately 25% to 40% of the clavulanic acid are excreted unchanged in urine during the first 6 hours.

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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Gram Positive Aerobes:

Staphylococcus aureus (lactamase and non lactamase producing).Enterococcus faecalis.Staphylococcus epidermidis (lactamase and non lactamase producing).Staphylococcus saprophyticus (lactamase and non lactamase producing).Streptococcus pneumoniae.Streptococcus pyogenes.Streptococcus viridans group.

DELTACLAV (Bacteriological DELTACLAV (Bacteriological spectrumspectrum

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Gram Negative Aerobes:Enterobacter species Escherichia coli (lactamase and non lactamase producing)Haemophilus influenzae (lactamase and non lactamase producing)Klebsiella species (All known strains are lactamase producing)Moraxella catarrhalis (lactamase and non lactamase producing)Eikenella corrodens (lactamase and non lactamase producing)Neisseria gonorrhoeae (lactamase and non lactamase producing)Proteus mirabilis (lactamase and non lactamase producing)

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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Anaerobic Bacteria:

Bacteroides species, including Bacteroides fragilis (lactamase and non lactamase producing). Fusobacterium species (lactamase and non lactamase producing).Peptostreptococcus species.

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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Respiratory Tract Infections

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INDICATIONS AND USAGE:DELTACLAV is indicated in the treatment ofinfections caused by susceptible strains of thedesignated organisms in the conditionslisted below:

Lower Respiratory Tract Infections caused by lactamase producing strains of H. influenzae and M. catarrhalis.Otitis Media caused by lactamase producing strains of H. influenzae and M. catarrhalis.

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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Sinusitis caused by lactamase producing strains of H. influenzae and M. catarrhalis.Skin and Skin Structure Infections caused by lactamase producing strains of S. aureus,E. coli, and Klebsiella species.Urinary Tract Infections caused by lactamase producing strains of E. coli, Klebsiella species, and Enterobacter species.

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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CONTRAINDICATIONS:

DELTACLAV is contraindicated in patients with a history of allergic reactions to any penicillin.

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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DOSAGE AND ADMINISTRATION:Neonates and infants aged <12 weeks (3 months):

The recommended dose of DELTACLAV is 30 mg/kg/day divided q12h, based on the amoxicillin component.

DELTACLAV DELTACLAV (Amoxicillin / Clavulanate potassium)

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DOSAGE AND ADMINISTRATION

  Children:

  -Otitis media, recurrent sinusitis, lower respiratory tract infections, and more severe infections 45 mg/kg/day q12h.

  -Less severe infections 25 mg/kg/day q12h.

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CONCLUSIONS: In comparison with the original formulation administered tid for 10 days in the treatment of AOM in children, the new formulation administered bid for 10 days provides at least equivalent efficacy and causes substantially less diarrhea.

78.886.5

0102030405060708090

Old Conc. New Conc.

Eradication %Diarrhoea

Hoberman A, Paradise JL, Burch DJ, Valinski WA, Hedrick JA, Aronovitz GH, Drehobl MA, Rogers JM.

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The new recommended concentrations.The recommended 1st line therapy by the American Academy of Pediatrics in AOM.Effective eradication of Upper and Lower respiratory tract infective bacteria.High bactericidal activity against resistant bacteria resulting in 1st time success.Palatable banana taste with no rejection.Affordable and competitive price.

DELTACLAV DELTACLAV (why)(why)(Amoxicillin / Clavulanate potassium)

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228.5

L.E. 13

457

L.E. 18

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