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KORELASI URINE DAN SERUM BIOMARKER PADA KERUSAKAN GINJAL DAN
SURVIVAL DI ANJING SECARA ALAMI TERKENA PENYAKIT GINJAL
PROTEINURIC KRONIS
J.A. Hokamp, R.E. Cianio!o, M. Bo""#$$, G.E. L##$, S.L. B#na!i,
M. Ko%a&$k', an( M.B.
Na)i*'
P#n'aki* "in+a! k&oni$ CKD- a(a!a p#n'#)a) /m/m
(a&i mo&)i(i*a$ (an mo&*a!i*a$
pa(a an+in", (an m#*o(# non in%a$i0 $aa* (ia"no$i$
$#&in" k#k/&an"an $#n$i*i%i*a$,
$p#$i0i$i*a$, a*a/ k#(/an'a /n*/k (#*#k$i (ini p#n'aki* (an
/n*/k i(#n*i0ika$i (a&i p&o$#$
p#n'aki* 'an" m#n(a$a&in'a. K!ini$, CKD pa(a an+in"
)ia$an'a *#&(#*#k$i o!# a(an'a
a1o*#mia "in+a!, p&o*#in/&ia "in+a! p#&$i$*#n, a*a/
k#(/an'a, $#&in" )#&$amaan (#n"an
p#n/&/nan /&in )#&kon$#n*&a$i k#mamp/an,
(i*#m/kan a)no&ma! pa(a p#m#&ik$aan $#(im#n
/&in $#p#&*i a(an'a "ip$ (i $#(im#n-, (an a)no&ma!
p#nampi!an "in+a! pa(a USG. p&o*#in/&ia
"in+a! p#&$i$*#n, )ia$an'a m#n"/k/& p&o*#in
/&in#2 ka*inin UPC-, (apa* m#n+a(i in(ika*o&
a3a! CKD pa(a an+in", (an i*/ m#&/pakan 0ak*o&
p&o"no$*ik n#"a*i0 pa(a an+in" (#n"an
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CKD. Biop$i "in+a! (ian""ap $#)a"ai $*an(a& #ma$ /n*/k
m#n#n*/kan +#ni$ k#&/$akan "in+a!,
*#*api m#&/pakan p&o$#(/& in%a$i0 (an *i(ak !a'ak
(a!am $#*iap ka$/$ kana k#n(a!a
0inan$ia! a*a/ k#$#a*an #3an. O!# kana i*/, k/&an" in%a$i0,
m/&a, $#n$i*i0 (an $p#$i0ik
m#*o(# 0i /n*/k m#n"#%a!/a$i k#)#&a(aan, ka&ak*#&,
(an *in"ka* k#pa&aan k#&/$akan "in+a!
pa(a an+in" 'an" (ip#&!/kan.
Hi!an"n'a p&o*#in /&in# a(a!a a! /m/m pa(a an+in" (#n"an
p#n'aki* "in+a! k&oni$
CKD-. Un*/k m#n"#%a!/a$i )ioma&k#& )a&/ TI-
k#&/$akan "!om#&/!/$ (an */)/!oin*#&$*i*ia!
(i)an(in"kan (#n"an i$*o!o"i (an $#)a"ai in(ika*o&
k#!an"$/n"an i(/p pa(a an+in" (#n"an
a!ami, CKD p&o*#in/&i.
P#n#!i*ian *&o$p#k*i0 ini m#n""/nakan $amp#! an+in"
$/p#&na*an /&in#, $#&/m, (an +a&in"an "in+a!
(ik/mp/!kan o!# (ok*#& #3an an+in" (an (i$#&akan k#
In*#&na*iona!
V#*#&ina&' R#na! Pa*o!o"' S#&%i# IVRPS- /n*/k */+/an
(ia"no$*ik an*a&a Jan/a&i 4556 (an
S#p*#m)#& 4578. S#m/a $amp#! (iki&im (an )ia$an'a
(i*#&ima (an (ip&o$#$ a&i )#&ik/*n'a
ko!#k$i. U&in# $/p#&na*an (an $#&/m a!i9/o*#( (an
(i$impan pa(a :65 ; C $ampai ana!i$i$.
Ka$/$ (ika*#"o&ikan $#)a"ai m#mi!iki *i(ak ak*i0 $#(im#n
/&in, in0#k$i $a!/&an k#mi ak*i0
)#&(a$a&kan )/(a'a a*a/ $#(im#n *#m/an-, #ma*/&ia 5?
!apan"an-@, a*a/ pi/&ia = 75 $#! (a&a p/*i p#& >5?
!apan"an-,
(ii(#n*i0ika$i )aik pa(a $amp#! 'an" (i$ampaikan, +ika
*#&$#(ia, a*a/ (a!am 3ak*/ > min""/
)iop$i "in+a!. Ka$/$ (#n"an $#(im#n ak*i0 (ik#!/a&kan
(a&i ana!i$i$. )iop$i "in+a! $#a&a &/*in
(ip&o$#$ /n*/k aa'a LM- (an mik&o$kop #!#k*&on
*&an$mi$i TEM- $#p#&*i 'an" (i+#!a$kan
$#)#!/mn'a. K&i*#&ia /n*/k (ia"no$i$ p#n'aki* "in+a!
*#&ma$/k p&o*#in/&ia p#&$i$*#n,
a1o*#mia, a*a/ k#(/an'a. Ka$/$ (ika*#"o&ikan $#)a"ai
m#mi!iki CKD, #(#&a "in+a! ak/*
AKI-, )aik CKD (an AKI, a*a/ *i(ak in0o&ma$i 'an" /k/p /n*/k
m#n#n*/kan k&oni$i*a$
p#n'aki* "in+a!. CKD a(a!a (i(#0ini$ikan o!# )/k*i
p#n'aki* "in+a! $#!ama minima! 8 )/!an
a*a/ )/k*i k&oni$i*a$ pa(a USG "in+a! a*a/ i$*o!o"i.
P#n#!i*ian *&o$p#k*i0 m#n""/nakan /&in#, $#&/m, (an
)iop$i "in+a! (a&i an+in"
(#n"an p#n'aki* "in+a!, 7 (a&i 'an" m#mi!iki CKD
p&o*#in/&i. Bioma&k#& (i#%a!/a$i (an
)#&ko!a$i (#n"an k#&/$akan pa*o!o"i$ "in+a!, (an
a$o$ia$i 'an" $i"ni0ikan, k#p#kaan, (an
ko*a:ko*a $p#$i0i$i*a$ )ioma&k#& /n*/k +#ni$ p#n'aki*
"in+a! (i*#n*/kan. Ek$k$i p#aan
im/no"!o)/!in M I"M E- (an im/no"!o)/!in G I"G E- )#&ko!a$i
pa!in" k/a* (#n"an
k#&/$akan "!om#&/!/$ )#&(a$a&kan mik&o$kop
aa'a & 5,6 (an 5,F, ma$in":ma$in" P
5,57-. ka*inin $#&/m SC&- )#&ko!a$i pa!in" k/a*
(#n"an k#&/$akan TI & 5.5, P
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5,57-. U&in# I"M ka*inin (an /&in NAG ka*inin m#mi!iki
$#n$i*i%i*a$ *#&*in""i -
(an $p#$i0ik ko*a 0i 6- /n*/k m#n(#*#k$i k#k#)a!an
"!om#&/!on#0&i*i$ komp!#k$:
(im#(ia$i. M#$kip/n $#a&a in(i%i(/ pa!in" )ioma&k#&
'an" $#a&a $i"ni0ikan )#&/)/n"an
(#n"an p#n/&/nan 3ak*/ k#!an"$/n"an i(/p P 5,5-, (a!am
ana!i$i$ m/!*i%a&ia*, SC&,
I"ME, (an k#&/$akan "!om#&/!/$ )#&(a$a&kan
mik&o$kop #!#k*&on *&an$mi$i TEM- a(a!a
$a*/:$a*/n'a )ioma&k#& $#a&a $i"ni0ikan *#&kai*
(#n"an 3ak*/ k#!an"$/n"an i(/p SC&2 P
5,557 I"ME2 P 5,556 TEM2 P 5,57-. Bioma&k#& /&in#
No%#! (an #$ 'an" )#&"/na
/n*/k m#n(#*#k$i k#&/$akan "!om#&/!/$ (an TI pa(a an+in"
(#n"an CKD p&o*#in/&i (an
m/n"kin m#mp(ik$i $p#$i0ik +#ni$ p#n'aki* (an k#!an"$/n"an
i(/p.
