AlchemistTM II: Capacity, reproducibility and efficiency of an

high-throughput crystallization screen preparation system.

Craig SterlingDirector of Business Development

Rigaku

CrystalTrakTM

Information Flow & Management

Automated Protein Crystallization Platform

AlchemistTM IIScreen Maker

Minstrel HT & Gallery 700 IncubatorsImaging and Incubation

Phoenix RE ExperimentalPlate Setup

Integration ModuleIncluding Robotic Arm, plate

and block storage, mixing station, piercing station, and

foil and tape sealing

CrystalMationTM Features

AlchemistTM II, Phoenix RE, MinstrelTM HT imaging system and GalleryTM 700 incubators operate independently or as part of the completely integrated CrystalMation system Allows instruments to be added over time to meet budgets Easy and seamless integration

CrystalTrakTM relational database application Easy-to-use design is manageable by tech level personnel Mixing, Piercing & Sealing accessories for CrystalMationTM

system Low cost operation of $10 per plate including maintenance

costs and chemical costs

CrystalTrakTM

CrystalTrak seamlessly integrates the Rigaku Crystallization instruments, offering labs a complete end-to-end solution

Relational database tracks all of the necessary information used in crystallization trials such as chemicals, screens, protein samples, plate type information, images, and annotations

CrystalTrak simplifies and aids in the crystallization process by providing tools that enable users to greatly improve crystallization trial productivity with less user intervention. One-click optimization tools Intuitive screen design tools

CrystalTrak Web offers remote access to data

Custom Screen Maker – The Alchemist II

The best accuracy in the industry for handling stock solutions of all viscosities, dispensing volumes as low as 1µl using the TapperTM

technology

Produce liquid formulations without wasting chemicals during every cleaning, priming and wash cycle

74 Barcoded easy to swap reagents

No tedious setup, cleaning and maintenance

Dedicated syringe for each reagent

Easy screen design with CrystalTrak

NEW Seal-tight BirdFeedersTM

New threaded cap, Seal-tight design Long-term storage of stock solutions on deck Works with standard stock solution bottles

Barcode Tracking of birdfeeders and stock solutions Autoclave-able design Easy-pour design for replacement of stocks Four different stock solution sizes

20ml in Birdfeeder with cap Good for expensive stocks and additives

125ml Nalgene bottles 250ml Nalgene bottles

Three Syringe sizes (Eppendorf) 100ul 1ml 10ml

Alchemist II

CrystalTrakTM

Information Flow & Management

Automated Protein Crystallization Platform

AlchemistTM IIScreen Maker

Minstrel HT & Gallery 700 IncubatorsImaging and Incubation

Phoenix RE ExperimentalPlate Setup

Integration ModuleIncluding Robotic Arm, plate

and block storage, mixing station, piercing station, and

foil and tape sealing