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TMA BI - MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
VOLUME 15.5 SEPTEMBER - OCTOBER 2020
WELCOME TO
th th th thWORKSHOP: 24 - 25 Feb 2021 | CONFERENCE: 26 - 28 Feb 2021
CRITICARE 2021 - VIRTUAL CONFERENCETHEME SAFETY AND EFFICIENCY AMIDST RESOURCE LIMITATION
WWW.ISCCM.ORG
CRITICAL CAREC O M M U N I C A T I O N S
CONTENTS1. Editorial
2. Message from the president
3. Message from the general secretary
4. Editorial Board Critical Care Communications 2020 -
2021Editorial Board Critical Care Communications
5. List of New Members
6.Corona Warriors Award
7. ISCCM postal cover release.
8. COVID-19 ARDS: Timing of Intubation- An Intensivist’s Dilemma
9. Spiritual care in healthcare
10. Impact of COVID-19 Pandemic on Family equations of Health-
care workers.
11. An Ode to Transcranial Doppler Sonography
12. POCUS in acute kidney injury-lest we forget
13. Journal section
14. Quiz Section
Editorial Office
Dr. Deepak Govil, President - Elect, ISCCM,
Chairman, Scientific Committee, Criticare 2021
Director Critical Care Medanta The Medicity, Gurgaon
Mobile: + 91 9818056688
Email: [email protected], [email protected]
Address: B-8/6137, Vasant Kunj, Delhi
Published By :
Indian Society of Critical Care Medicine
For Free Circulation Amongst Medical Professionals
Unit 13 & 14, First Floor, Hind Service Industries
Premises Co-operative Society, Near Chaitya
Bhoomi, Off Veer Savarkar Marg,
Dadar, Mumbai - 400028
Tel. 022-24444737, Telefax: 022 - 24460348,
Email: [email protected]
Editorial...TM
www. .orgisccm
I hope this message nd you in good health. It has been a
wonderful journey for us so far despite facing many
challenges. We are witnessing a new normal where most of
our academic activities are being done through online
means. I would like to like congratulate the leadership and
members for successful completion of E- Criticare.
Notwithstanding the difcult situation faced by critical care
community, the enthusiasm and participation was amazing
in the recently concluded E criticare. The recent decision
by ISCCM to conduct CRITICARE-2021 as completely
virtual conference is laudable and germane in the present
scenario. ISCCM is in the forefront in spreading critical
care education amongst students and practitioners through
its online platforms like ISCCM Academy.
We present you another edition of Critical care communication. To widen the horizon, newer
topics like Use of transcranial doppler and renal ultrasound have been included. The great
conundrum of timing of intubation in COVID ARDS has been addressed. The role of spiritual care
and impact of COVID on the family equation of healthcare providers and many more excellent
topics have been added. I thank all of you for astounding success and continued support for critical
care communications.
Dr. Deepak GovilMD, EDIC, FCCMPresident - Elect, ISCCM,Chairman, Scientic Committee, CRITICARE 2021Director, Critical Care, Medanta The Medicity, GurgaonEmail: [email protected] , [email protected]: +91 9818056688
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
President’s DeskTM
www. .orgisccm
Dear FriendsGreetings & warm wishes for Christmas and new year.
After eventful 2020, I am reasonably hopeful that new year
will bring smiles back on the faces of men & women.
Year 2020, though disruptive, ushered lot of initiatives &
changes in the lives of all of us- primarily the use of
technology . It leapfrogged the education, training and
governance; bringing in transparency, participation of larger
cohort & outreach to far and wide across the globe,
dening new normals.
I am of the view that meeting of executive council and of
other committees be held virtually saving travel & money with more positive outcomes.
Examinations now should be online for all times to come & gradually simulation should become an
integral part of training & evaluation- preferably through ISCCM academy.
COVID pandemic has brought the spotlight on specialty of critical care highlighting the role of
intensivists. It highlighted our resilience, strength , great team work and areas we need to focus-
research, patient safety advocacy, technical evaluation of products used in critical care and
collaboration with industry & teaching institutions to help creating start ups and trained manpower
in critical care.
We took a conscious decision to have virtual congress in 2021 and to have next congress in
Ahemdabad as was planned earlier. We are trying our best to come up with an uptodate program
covering all the contemporary issues.I have no doubt future is bright & as a professional body we are ready to take all the challenges by
horn to come out victorious. We may have been scarred but our spirits are up with a motive to
serve the man kind.
Wish you all the best & stay safe
Dhruva ChaudhryMD(Med.), DNB (Med.), DM(PCCM), FICP, FICCM, FNCCPPresident, ISCCMOrganizing Chairman, CRITICARE 2021 Professor & Head PCCM, PGIMS, RohtakDean Medical Super-SpecialtyPT.B.D.S University of Health Sciences, RohtakEmail: [email protected]: +91 94160 51616
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
General Secretary's DeskTM
www. .orgisccm
Dear FriendsHope all of you are safe and doing well. The pandemic continues
to test the resolve of all sections of the society across geo-
political borders. While the situation has stretched our resources,
it has also taught us a few lessons. The basics of hygiene and
safety have never been in as much focus before. Team work and
coordination as work ethics have been highlighted greatly in the
past ten months. Scientic temper and rationale have been
constantly under the limelight. All these principles have been the
forte of Intensivists long before the pandemic started. This is
probably the reason why Intensivists have been the torchbearers
in the march against the wily virus. The ISCCM has continued its endeavor to spread scientic
information and knowledge during these difcult times. As we
know, conventions and large meetings have been on hold as on date. Travel within the country is also a tricky
step. In view of this situation, the Executive Committee has resolved to defer a physical conference at
Ahmedabad as initially planned in February 2021. A full edged virtual Criticare 2021 is being organized
instead. The scientic program is getting ready and so are the logistics. As a initial exercise, a mid-term one
day meeting ( E-Criticare) was organized on the 8th of November and this was enthusiastically received.
More than three thousand members logged in into the event. The feedback received from the participants
including friends from Industry have been analysed and will be used to improve the quality during Criticare.
Intensivists have been in the forefront of the battle against COVID 19. Some of us have weathered the storm
and have become worthy survivors. There have been an unfortunate few who could not. The ISCCM wishes
to stand by the families if such martyrs. The society constituted a committee to suggest a scheme for a
benevolent fund. A mail has been circulated to all of you and the suggestions therefrom, will be implemented. The academic focus of the society has not dimmed despite challenges. The college has successfully completed
all exams and certications while starting a new teaching initiative – the STEP program. The Journal has also
established itself as a reliable source for meaningful information.
The dening moment for the society and the specialty came late in October when the department of Posts
released a postal cover acknowledging the role of ISCCM as a leading light in the Intensive Care driven ght
against the pandemic. It was indeed a recognition that was rightfully given.
Overall, the testing times have thrown up challenges which we have unitedly fought and found new ways of
engaging in our core activities. Hopefully the clouds will clear soon and the sun will shine brightly once again
Dr. Srinivas SamavedamMD, DNB, FRCP, FNB, EDIC, FICCM, DMLE, MBAGeneral Secretary, ISCCMOrganising Secretary, CRITICARE 2021Head, Critical Care, Medical Director Virinchi Hospitals, HyderabadEmail: [email protected]: +91 98663 43632
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
EDITORIAL BOARD CRITICAL CARE COMMUNICATIONS 2020 - 2021
Dr. Anuj ClerkMD,IDCCM,FNB Critical Care EDIC,FIECMO
Head, Intensive Care Services
Sunshine Global Hospital, Surat
Email: [email protected]
Mob: 7574851424
Dr. Mozammil ShafiMD, FNB, EDIC
Consultant, Critical Care Medicine
Medanta The Medicity, Gurugram
Email: [email protected]
Mob: 9599557808
Dr. Vinay SinghalMD
Additional Director & Head Department of
Critical Care Medicine Fortis Hospital, Ludhiana
Email: [email protected]
Mob: 9915285833
Dr. Asif AhmedDNB (Gold Medal) Anaesthesiology, IDCCM
Sr. Consultant & Head of Department
Dept of Critical Care Medicine
Tata Main Hospital, Jamshedpur
Email: [email protected]
Mob: 9204657195
Dr. Khalid KhatibM.D. (Medicine), FICCM, FICP.
Professor, Department of Medicine,
Smt. Kashibai Navale Medical College,
Narhe, Pune, Maharashtra, India
Email: [email protected]
Mob: 9822091745
Dr. Rajesh Mohan ShettyMBBS, FRCP(Edinburgh), FRCA(UK), FCICM(Aus&NZ)
FFICM(UK), FICCM(India)
BSE Accreditation (Transthoracic Echocardiography)
Chief of Clinical Services and Lead Consultant in
the Department of Critical Care Medicine
Manipal Hospital Whitefield, Bengaluru
Email: [email protected]
Mob: 9886660477
Dr. Prashant NasaMD, IDCCM, FNB(Critical Care)
FICCM, EDICM, RCP-SCE(Acute Medicine) CIC
Head of Critical Care Medicine
Head of Infection Control and
Antimicrobial Stewardship
NMC Speciality Hospital, Dubai (UAE)
Dr. Deepak GovilMD, EDIC, FCCM
Director, Critical Care, Medanta The Medicity, Gurgaon
Email: [email protected] | Mob: 9818056688
EDITOR IN CHIEF
ASSOCIATE EDITORS
EDITORIAL BOARD
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
EDITORIAL BOARD CRITICAL CARE COMMUNICATIONS 2020 - 2021
JOURNAL SCAN
Dr. Kapil Dev SoniMD
Additional Prof.Critical & Intensive Care
JPN Apex Trauma Centre AIIMS,New Delhi
Email: [email protected]
Mob: 9718661658
Dr. Sai Saran PVMD, IDCCM, DM, EDIC
Assistant Professor,
Department of Critical Care Medicine
Superspeciality Cancer Institute & Hospital,
CG City, Lucknow, UP
Email: [email protected]
Mob: 8004505719
Dr. Anand GuptaDA, IDCCM, IFCCM, EDIC
Senior Consultant,Head Surgical and
Transplant Critical Care
AIG Hospital, Gachigowli, Hyderabad
Email: [email protected]
Mob: 9313392757
Dr. Bikram GuptaMD, PDCC (CCM), EDIC (UK), FACEE - India
Associate Professor
Division of Critical Care Medicine
Dept of Anaesthesiology & Critical Care
IMS, BHU, Varanasi, Uttar Pradesh
Email: [email protected]
Mob: 8400100128
Dr. Hrishikesh JhaDA, PGDDC
Senior Consultant and Head - Critical Care
Gurunanak Hospital and
Research Centre, Ranchi
Email: [email protected]
Mob: 9471710607
Surg Ltd Cdr
(Dr) Abdul NasserMBBS, DNB (Anaesth)
Anaesthesiologist, Indian Navy
INHS Jeevanti, Goa
Email: [email protected]
Mob: 9560837993
QUIZ SECTION
IMAGES SECTION
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
CONDOLENCE
Dr Manuj Sodhi
We are extremely saddened to announced the untimely demise of our dear friend
and colleague Dr Manuj Sodhi. Dr Manuj was an extremely hardworking,
compassionate and a noble soul with an extraordinary ability to connect with the
patients and their families. A devoted family man and intensely cordial to the
colleagues, his departure has created an eternal void which sems difcult to heal.
Dr Manuj is survived by his wife and a daughter. May the departed soul rest in
peace. Our thought and prayers are with his family.
WELCOME NEW MEMBERS
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
Name City Category MembershipNo
Aditya Sharma Ambala Life Members 20/S-2072
Shwethapriya R Udupi Life Members 20/R-746
Prakash Priyadarshi Patna Associate Life Member 20/P-1200
Sachin Udmale Ahmednagar Associate Life Member 20/U-77
Kapil Rastogi Lucknow Life Members 20/R-744
Manjusha Shah Sholapur Life Members 20/S-2032
Merina Thomas Bangalore Associate Life Member (Nurse) 20/T-437
Amit Panigrahi Visakhapatnam Life Members 20/P-1183
Nandita Samal Cuttack Associate Life Member (Nurse) 20/S-2031
Eliza Mahakud Associate Life Member (Nurse) 20/M-1092
Raju G Calicut Life Members 20/G-916
Vineet Kumar Rohtak Life Members 20/K-1305
Sujatha CH Guntur Associate Life Member (Nurse) 20/C-571
Niranjan H R Mumbai Life Members 20/H-178
Kedarnath Behera Cuttack Associate Life Member (Nurse) 20/B-888
Anusha R Tirupur Life Members 20/R-736
Mohammed Irfan Coimbatore Life Members 20/I-63
Asma Chouhan Thane Associate Life Member 20/C-572
Manisha Saini Sikar Life Members 20/S-2033
Santosini Panda Associate Life Member (Nurse) 20/P-1184
Jyothi Boppudi Guntur Associate Life Member (Nurse) 20/B-889
Vijaya Pagidipalli Guntur Associate Life Member (Nurse) 20/P-1185
Neinika Nayak Cuttack Associate Life Member (Nurse) 20/N-358
Sarmitha Swain Associate Life Member (Nurse) 20/S-2034
Abhishek Joshi Indore Associate Life Member 20/J-599
Nageswara Rao Yamavarapu Guntur Associate Life Member (Nurse) 20/Y-91
Avanti Purohit Mumbai Life Members 20/P-1186
Rohit Jain Jamalpur Associate Life Member 20/J-600
Tukaram Nalwad Parbhani Associate Life Member 20/N-359
Sathya Narayanan.K Vellore Life Members 20/N-360
Chennigari Ramalingam Vardhan Secunderabad Life Members 20/V-422
Rayana Prakash Hyderabad Life Members 20/P-1187
Kumaragurubaran TR Nagapattinam Life Members 20/T-438
Sindhu Baglur Bangalore Life Members 20/B-890
Annapoorani Karunanithi Chennai Life Members 20/K-1306
Arun T C Davanagere Life Members 20/T-439
Sangita Kumawat Sikar Life Members 20/K-1307
Sandhya Ravi Kochi Life Members 20/R-737
Jyotsna Mali Sindhudurg Life Members 20/M-1093
Maneesh Kumar Kanpur Associate Life Member (Nurse) 20/K-1308
Amit Mishra KANNAUJ Associate Life Member (Nurse) 20/M-1094
Amarjeet Kumar Patna Life Members 20/K-1309
Anindita Chakraborty Mumbai Life Members 20/C-573
M V Naveen Kolar Life Members 20/N-361
Saibalaji A Hyderabad Life Members 20/A-728
Sonu Jhunjhunu Life Members 20/S-2078
Saji Shanmughan Thiruvananthapuram Life Members 20/S-2035
Riya Verma PANKI Associate Life Member (Nurse) 20/V-423
Priti Jayswal Sultanpur Associate Life Member (Nurse) 20/J-601
Sachin Katkade Pune Associate Life Member 20/K-1310
Amrita Swati Faridabad Life Members 20/S-2036
WELCOME NEW MEMBERS
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A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
Name City Category MembershipNo
Michelle Fernandes Mumbai Associate Life Member 20/F-4
Yogesh Jharwal Jaipur Life Members 20/J-602
Sheikh Ilyas Sheikh Washim Associate Life Member 20/S-2037
Mohd Anas Nagaur Associate Life Member 20/A-729
Indumathi S Bangalore Life Members 20/S-2038
Banothu Neha Bangalore Associate Life Member 20/N-362
Bangari Prashanth Karimnagar Associate Life Member (Nurse) 20/P-1189
Thallapelli Anusha Adilabad Associate Life Member (Nurse) 20/A-730
Vijaymahantesh Soudri Koppal Life Members 20/S-2039
Marutheesh Mallappa Turnkur Life Members 20/M-1095
Ashwani Sharma New Delhi Life Members 20/S-2040
Karna Siva Kumar Cuddapah Life Members 20/S-2041
Ashwini Pednekar Goa Life Members 20/P-1190
Shyam Singh New Delhi Life Members 20/S-2042
Seema Bhalodia Rajkot Associate Life Member 20/B-891
Ayyappan C Madurai Life Members 20/C-580
Ankur Gupta Chandigarh Life Members 20/G-917
Vipulkumar Parmar Baroda Associate Life Member (Nurse) 20/P-1191
Suresh Kumar S Chennai Life Members 20/S-2043
Aditya Gupta Kanpur Associate Life Member 20/G-918
Banoth Vani Khammam Associate Life Member (Nurse) 20/V-424
Aleena Catherin Roy Wayanad Associate Life Member (Nurse) 20/C-574
Tesny Babu Kollam Associate Life Member (Nurse) 20/B-892
Stef Stef Alappuzha Associate Life Member (Nurse) 20/S-2044
Tushar Patel Baroda Life Members 20/P-1192
Bala Ponnuthurai Virudhunagar Life Members 20/P-1193
Jagtaran Singh Ludhiana Associate Life Member 20/S-2045
Kolluru Madhavi Hyderabad Associate Life Member (Nurse) 20/M-1096
Vrushali Patil Nashik Associate Life Member 20/P-1194
Hariom Hariom Dholpur Associate Life Member (Nurse) 20/H-179
Pooja Joshi New Delhi Associate Life Member 20/J-603
Anoop Pn Kottayam Life Members 20/P-1195
Mahesh Ohar Buldana Life Members 20/O-28
Sujata Das Bhubaneswar Associate Life Member (Nurse) 20/D-715
Navin Saxena Agra Associate Life Member (Nurse) 20/S-2046
Satyabrata Dash Bhubaneswar Life Members 20/D-723
Timal Chacko Bangalore Associate Life Member (Nurse) 20/C-575
Jinu Joseph Alappuzha Associate Life Member (Nurse) 20/J-604
Mohit Katare Indore Life Members 20/K-1311
Mayurdhwaja Rath Bhubaneswar Life Members 20/R-738
Denita DSA Udupi Associate Life Member (Nurse) 20/D-716
Malik Mohammad Calicut Life Members 20/M-1097
Nisha N Kollam Associate Life Member (Nurse) 20/N-363
Harindran N Ernakulam Life Members 20/N-364
Vivek Prasad Thiruvananthapuram Life Members 20/P-1196
Varun Rajpal Agra Life Members 20/R-739
Vettri Kkaviyan DHARMAPURI Associate Life Member (Nurse) 20/K-1312
Ramandeep Kaur Amritsar Associate Life Member (Nurse) 20/K-1313
Rajesh Verma New Delhi Associate Life Member 20/V-425
Narendra Patil Kolhapur Life Members 20/P-1197
Mariya Vincy Wayanad Associate Life Member (Nurse) 20/V-426
Suvarna Shirsekar Mumbai Associate Life Member (Nurse) 20/S-2047
WELCOME NEW MEMBERS
THE CRITICAL CARE COMMUNICATIONS »
A BI-MONTHLY NEWSLETTER OF INDIAN SOCIETY OF CRITICAL CARE MEDICINE
Name City Category MembershipNo
Anisha Jose Wayanad Associate Life Member (Nurse) 20/J-605
Mohd Akram Padiyar Sikar Associate Life Member 20/P-1188
Pasupathi Selvam Viluppuram Associate Life Member (Nurse) 20/S-2048
Ranjeet Bondar Osmanabad Life Members 20/B-893
Parth Kalaria Rajkot Associate Life Member 20/K-1314
Sunil Sorout Faridabad Life Members 20/S-2049
Anshu Thomas New Delhi Associate Life Member (Nurse) 20/T-440
Sushmita John Bhilwara Associate Life Member (Nurse) 20/J-606
Mohammed Washid Kozhikode Life Members 20/W-87
Shubham Nahar Pune Associate Life Member 20/N-365
Gaurav Arya Bhiwani Life Members 20/A-731
Sanket Panchasara Gandhinagar Life Members 20/P-1198
Shruti Patel Ahmedabad Associate Life Member 20/P-1199
Panugothu Ram Babu Naik Guntur Associate Life Member (Nurse) 20/R-740
Dhaneesh C Malappuram Life Members 20/C-576
Joby Jose Bangalore Associate Life Member (Nurse) 20/J-607
Kalavati Kalavati Bidar Associate Life Member (Nurse) 20/K-1315
Rakesh Dagar New Delhi Life Members 20/D-717
Shabbir Mulla Belgaum Life Members 20/M-1098
Unnikrishnan K P Bangalore Associate Life Member (Nurse) 20/K-1316
Irshad Lone Bangalore Associate Life Member (Nurse) 20/L-147
Sajad Manzoor Lone Bangalore Associate Life Member (Nurse) 20/L-148
Noorjahan Begum Bhubaneswar Associate Life Member (Nurse) 20/B-894
Sibnarayan Sendha Cuttack Life Members 20/S-2050
Bhoomika Barvaliya Ahmedabad Associate Life Member 20/B-895
Harphool Singh Jaipur Associate Life Member (Nurse) 20/S-2051
Narendra Choudhary Sikar Life Members 20/C-577
Dhawal Prajapati Associate Life Member 20/P-1201
Nikhil Shinde Buldhana Life Members 20/S-2052
Jaspreet Kaur Jagraon Associate Life Member (Nurse) 20/K-1317
Bilal S A Kollam Associate Life Member 20/S-2053
Deeksha Deeksha Una Associate Life Member (Nurse) 20/D-718
Gayathri Udumbasseri Kozhikode Associate Life Member 20/U-75
P. Vishal New Delhi Associate Life Member 20/V-427
Dolma Nayal Almora Associate Life Member (Nurse) 20/N-366
Mukesh Singh New Delhi Associate Life Member 20/S-2054
Barkha Dodani Pune Life Members 20/D-719
Viraj Mohite Life Members 20/M-1099
Abhijit Telkhade Mumbai Life Members 20/T-441
Prakash T Ernakulam Associate Life Member (Nurse) 20/T-442
Mohammad Khaja Medak Associate Life Member (Nurse) 20/K-1318
Sajith S Idukki Associate Life Member (Nurse) 20/S-2055
Devang Priyadarshi Ahmedabad Life Members 20/P-1202
Jaskirat Singh Jammu Life Members 20/S-2066
Chaithra S Bangalore Associate Life Member (Nurse) 20/S-2056
Ranjith N S New Delhi Associate Life Member (Nurse) 20/N-367
Anil Kumar Jhunjhunu Associate Life Member (Nurse) 20/K-1319
Anita Anita Jaipur Associate Life Member (Nurse) 20/A-732
Grace Mathew Malappuram Associate Life Member (Nurse) 20/M-1100
Jawahar K Vellore Associate Life Member (Nurse) 20/K-1320
WELCOME NEW MEMBERS
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Name City Category MembershipNo
Ananthakani Ramalingam Tiruvarur Associate Life Member (Nurse) 20/R-741
Mudasir Osmani Hyderabad Associate Life Member 20/O-29
Rajvi Patel Surat Life Members 20/P-1203
Indudipa Sinha Behala Associate Life Member 20/S-2057
D. Nithya D Perambalur Associate Life Member (Nurse) 20/D-720
Sandeep Kumar Sharma Mumbai Life Members 20/S-2058
Ashok Sehgal Jalandhar Life Members 20/S-2059
Prerna Bedi Panchkula Life Members 20/B-896
Kamna Kakkar Gurugram Life Members 20/K-1321
Chintha Sriram Nellore Life Members 20/S-2060
Kanaga Pv Thiruvallur Associate Life Member (Nurse) 20/P-1204
Dundigala Kumar Nalgonda Associate Life Member (Nurse) 20/K-1322
Varun Chalil Navi Mumbai Life Members 20/C-578
Lavanya K Hyderabad Life Members 20/K-1323
Sathya S Chittoor Associate Life Member (Nurse) 20/S-2061
Sunil Kuldeep Jaipur Life Members 20/K-1324
Danish Siddiqui Mumbai Associate Life Member 20/S-2062
Tarique Anwar Sayyed Nashik Associate Life Member 20/S-2063
Abhishek Badave Pune Life Members 20/B-897
Sarita Yadav Jaipur Associate Life Member (Nurse) 20/Y-92
Prarabdha Agrawal Raipur Associate Life Member 20/A-733
Mohammed Naseem Khan Mumbai Associate Life Member 20/K-1325
Prashant Choudhary Ghaziabad Life Members 20/C-579
Kevin Bora Pune Life Members 20/B-898
Manasi Shahane Pune Life Members 20/S-2064
Sagar Pithiya Rajkot Life Members 20/P-1205
Karthi Keyan Tirupur Associate Life Member (Nurse) 20/K-1326
Chirasmita Mahanta Sundargarh Associate Life Member (Nurse) 20/M-1101
Padmaja Pallavi Patna Life Members 20/P-1206
Priyanka K Vellore Associate Life Member (Nurse) 20/K-1327
Dayana V Viluppuram Associate Life Member (Nurse) 20/V-428
Rajalakshmi U Thoothukudi Associate Life Member (Nurse) 20/U-76
Rooba Krishnan Vandavasi Associate Life Member (Nurse) 20/K-1328
Nikita Trehan New Delhi Life Members 20/T-443
Saritha Joseph Wayanad Associate Life Member (Nurse) 20/J-608
Haritha P Kozhikode Associate Life Member (Nurse) 20/P-1207
Ayisha A S Kozhikode Associate Life Member (Nurse) 20/A-734
Jasteena James Kasaragod Associate Life Member (Nurse) 20/J-609
Satbir Malik Pune Life Members 20/M-1102
Raj Shukla Allahabad Life Members 20/S-2073
Puneeth J Bangalore Life Members 20/J-610
Sourabh Kumar Ranchi Life Members 20/K-1329
Smriti Sinha Mangalore Life Members 20/S-2065
Shubham Kumar New Delhi Life Members 20/K-1330
Abhinob Roy Gurugram Life Members 20/R-742
Anisha Beniwal Churu Life Members 20/B-899
Rohit Patnaik Bhubaneswar Life Members 20/P-1210
Taher Ahmed Hyderabad Life Members 20/A-735
Nitin Rai New Delhi Life Members 20/R-743
Balasubramaniaguhan Vivekanandan Tiruchirapalli Associate Life Member 20/V-429
Sai K.N Tirupathi Life Members 20/K-1334
Raj Singh Patna Life Members 20/S-2067
WELCOME NEW MEMBERS
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Saurav Shekhar Patna Life Members 20/S-2068
Priyanka Bansal Rohtak Life Members 20/B-900
Ritu Dave Udaipur Life Members 20/D-721
Lizy Vincent Thiruvananthapuram Associate Life Member 20/V-430
Abhishek Bharadwaj Bargarh Life Members 20/B-901
Prakhar Agarwal Bhopal Life Members 20/A-737
Arti Singh Kanpur Life Members 20/S-2069
Arul Selvan.U Chennai Life Members 20/S-2070
Sudheesh Kannan Bangalore Life Members 20/K-1331
Sunil Agarwal Raurkela Associate Life Member 20/A-736
Priyanka Dwivedi Gorakhpur Life Members 20/D-722
Arnab Choudhury Kolkata Life Members 20/C-581
Akash Singhal New Delhi Life Members 20/S-2071
Mahendra Meena Rishikesh Life Members 20/M-1103
Sachin Jadhav Bangalore Life Members 20/J-611
Mandeep Kaur Bhatia Hoshiarpur Life Members 20/B-904
Kamal Singh Jalandhar Life Members 20/S-2076
Professor Manisha New Delhi Life Members 20/M-1104
Ravindra Rahangdale Nagpur Life Members 20/R-745
Anirban Karmakar Kolkata Life Members 20/K-1332
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CORONA WARRIORS AWARD
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Dr Dhruva Chaudhry, President ISCCM, receiving Corona Warriors Appreciation
award by honorable Shri Anil Vij, Home and Health Minister, Haryana Govt
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ISCCM POSTAL COVER RELEASE
Ist Special postal cover to commemorate ISCCM day was released by Prof OP Kalra Vice Chancellor,
Pt B. D. Sharma University of Health Sciences, Rohtak and Mr S S Saini , Senior Supdt Post, Rohtak in
presence of Dr Dhruva Chaudhry, President ISCCM & Other dignitaries of the university
Dr Dhruva Chaudhry, President ISCCM, presenting the
1st day cover to honorable Shri Anil Vij, Home and Health Minister, Haryana Govt
ISCCM POSTAL COVER RELEASE
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COVID-19 ARDS: TIMING OF INTUBATION- AN INTENSIVIST’S DILEMMA
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Introduction
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and its clinical manifestation as Coronavirus Disease
2019 (COVID-19) presents an unparalleled worldwide public health problem [1]. Globally, as of 5:05pm CEST, 24 September 2020, there
have been 31,798,308 conrmed cases of COVID-19, including 973,653 deaths, reported to WHO [2]. The disease introduces a unique
pathophysiology and clinical course that puzzles the efcacy of the currently existing therapeutic approaches. This pandemic has to date
caused considerable social, economic, and political disruption globally with many countries adapting unprecedented social distancing
policies that have paralyzed economic activity [8]. About 5% of patients have severe disease. Some of these patients require ICU admission
and many of them will need mechanical ventilation. Mortality remains high in ventilated patients. It is not clear if timing of intubation has any
impact on outcomes. In this article we will be discussing the pathophysiology of COVID-19 ARDS and evidence related to timing of
ventilation.
Pathophysiology
Even though it can meet the ARDS Berlin denition [4, 5], the COVID-19 pneumonia is a specic disease with peculiar phenotypes. Its main
characteristic is the dissociation between the severity of the hypoxemia and the maintenance of relatively good respiratory mechanics [6].
Two phenotypes associated with the COVID-19 infection were observed in several observational studies carried out at various centers.
Type 1: Near normal pulmonary compliance with isolated viral pneumonia
In these patients, severe hypoxemia is associated with respiratory system compliance > 50 ml/cmH2O. The lung’s gas volume is high, the
recruitability is minimal, and the hypoxemia is likely due to the loss of hypoxic pulmonary vasoconstriction and impaired regulation of
pulmonary blood ow. Therefore, severe hypoxemia is primarily due to ventilation/perfusion (VA/Q) mismatch. High PEEP and prone
positioning do not improve oxygenation through recruitment of collapsed areas, but redistribute pulmonary perfusion, improving the VA/Q
relationship. Lung CT scans in those patients conrm that there are no signicant areas to recruit, but the right-to-left venous admixture is
typically around 50% [6].
Type 2: Decreased pulmonary compliance
In 20–30% of these COVID-19 patients admitted to the intensive care unit (ICU), severe hypoxemia is associated with compliance values <
40 ml/cmH2O, indicating severe ARDS [9]. It is certainly possible that their lower compliance (i.e., lower volumes and increased
recruitability) is due to the natural evolution of the disease, but could be the damage caused by the initial respiratory management. Many of
these patients receive CPAP or non-invasive ventilation before ICU admission and are subjected to very high respiratory drives, vigorous
inspiratory efforts, and highly negative intrathoracic pressures. Therefore, in addition to viral pneumonia, this self inicted ventilator-
induced lung injury leads to a decreased pulmonary compliance [10].
Management of ARDS
Invasive ventilation: timing and management of mechanical ventilation
Generally, in ARDS, the timing of intubation is related to clinical outcomes. Studies have shown that ARDS patients undergoing late
intubation have markedly higher mortality rates compared to those who were intubated early in the course of the illness [11].
The near universal approach to early mechanical ventilation at the onset of the COVID-19 pandemic was driven by early data from China
describing rapid deterioration with severe hypoxia, fears of patient self-induced lung injury and infection control measures [12].
Continuous monitoring and preparedness for urgent intubation are cornerstones in the treatment of COVID-19 patients with respiratory
failure. It is still not clear if early intubation is benecial in these patients. A delay of intubation in patients failing NIV worsens outcome [13].
However mortality remains high in ventilated patients. As the main issue in COVID-19 is hypoxia, adequate oxygenation by any other means
may give enough time for the lungs to heal thereby reducing the need for intubation and consequent increased mortality.
Dr. Shruti Krishnan MBBS, MD (KU) Internal Medicine
Senior Registrar, Internal Medicine and Health Check
Manipal Hospital Whiteeld
Mob:9886606621
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Gattinoni et al. proposed tailored modications to the usual ARDS principles based on the phenotype of the COVID-19 pneumonia.
Authors proposed a modication in ventilation strategy based on timing. In intubated type 1 phenotype patients, the management of
hypoxemia should be directed to improve the ventilation/perfusion mismatch by liberalized tidal volumes (7-8 ml/kg ideal body weight, to
avoid resorption atelectasis), limited PEEP levels (8-10cmH2O) and keeping the respiratory rate < 20 breaths per minute [17, 6, 18].
As lung damage progresses, type 2 phenotype arises following a similar pattern of a “typical” ARDS (bilateral inltrates, decreased
respiratory system compliance and increased lung weight) [17]. The standard approach of lung protective ventilation through low tidal
volumes (6ml/kg ideal body weight), PEEP levels (
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References
[1] Naming the coronavirus disease (COVID-19) and the virus that causes it. Available at:
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-
andthe-virus-that-causes-it. .
[2]WHO CORONAVIRUS DASHBOARD. Available at https://covid19.who.int/
[3] Coronavirus disease (COVID-2019) situation reports. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-
2019/situationreports.
[4] Force* TADT: Acute respiratory distress syndrome: the Berlin denition. JAMA. 2012;307(23):2526–33.
[5] Force ARDSDT, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute
respiratory distress syndrome: the Berlin denition. JAMA. 2012
[6] Gattinoni et al. COVID-19 pneumonia: ARDS or not ? Critical Care (2020) 24:154https://doi.org/10.1186/s13054-020-02880-z
[7] Pan C, Chen L, Lu C, Zhang W, Xia J-A, Sklar MC, et al. Lung recruitability in SARS-CoV-2 associated Acute Respiratory Distress
Syndrome: a single center, observational study. Am J Respir Crit Care Med. 2020. https ://doi.org/10.1164/rccm.20200 3-0527L E.
[8] Human Coronavirus Infections—Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and SARS-
CoV-2 https://doi.org/10.1016/B978-0-12-801238-3.11634-4
[9] Maiolo G, Collino F, Vasques F, Rapetti F, Tonetti T, Romitti F, Cressoni M, Chiumello D, Moerer O, Herrmann P, et al. Reclassifying acute
respiratory distress syndrome. Am J Respir Crit Care Med. 2018;197(12):1586–95
[10] Brochard L, Slutsky A, Pesenti A. Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Am J Respir
Crit Care Med. 2017;195(4):438–42.
[11] Arabi YM, Murthy S, Webb S (2020) COVID-19: a novel coronavirus and a novel challenge for critical care. Intensive Care Med.
https://doi.org/10.1007/s00134-020-05955-1
[12] AloknathPandyaMD,NavjotAriyanaKaurMD,DanielSacherDO,OisinO’CorragainMD,DanielSalernoMD,ParagDesaiMD,
SameepSehgalMD,MatthewGordonMD,RohitGuptaMD,NathanielMarchettiDO,HuaqingZhaoPhD,NicolePatlakhBSc,GerardJ.CrinerMD
,TempleUniversityCOVID-19 Research Group� Ventilatory Mechanics in Early vs Late Intubation in a Cohort of COVID-19 Patients With
Acute Respiratory Distress Syndrome: A Single Center’s Experience. Critical CareResearch Letter
[13] Kluge •U. Janssens • T. Welte • S.Weber-Carstens • G. Marx • C. Karagiannidis German recommendations for critically ill patients
with COVID-19S. Med Klin Intensivmed Notfmed https://doi.org/10.1007/s00063-020-00689-w
[15] Alhazzani W, Moller MH, Arabi YM, Loeb M, Gong MN, Fan E, et al. SurvivingSepsis campaign: guidelines on the management of
c r i t i c a l l y i l l a d u l t s w i t h c o r o n a v i r u s d i s e a s e 2 0 1 9 ( C OV I D - 1 9 ) . C r i t C a r e M e d . 2 0 2 0 ; 4 8 ( 6 ) : e 4 4 0 – 6 9 .
https://doi.org/10.1097/CCM.0000000000004363.
[16] Yong Hoon Lee 1, Keum-Ju Choi 2, Sun Ha Choi 1, Shin Yup Lee 1, Kyung Chan Kim 3, Eun Jin Kim 3,* and Jaehee Lee 1. Clinical
Signicance of Timing of Intubation in Critically Ill Patients with COVID-19: A Multi-Center Retrospective Study. J. Clin. Med. 2020, 9, 2847;
doi:10.3390/jcm9092847
[17] Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L, et al. COVID-19 pneumonia: different respiratory treatments for
different phenotypes? Intensive Care Med. 2020;46(6):1099–102. https://doi.org/10.1007/s00134-020-06033-2.
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[18] Management of COVID-19 Respiratory Distress. Available at: https://jamanetwork.com/journals/jama/fullarticle/2765302.
[19] Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with
traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301–8.
[20] Navas-Blanco and Dudaryk. Management of Respiratory Distress Syndrome due to COVID-19 infection. BMC Anesthesiology (2020)
20:177 https://doi.org/10.1186/s12871-020-01095-7
[21] Bartlett RH, Ogino MT, Brodie D, McMullan DM, Lorusso R, MacLaren G, et al. Initial ELSO guidance document: ECMO for COVID-19
patients with severe cardiopulmonary failure. ASAIO J. 2020;66(5):472–4. https://doi.org/10.1097/MAT.0000000000001173
[22] Eddy Fan, MD,a,b,c,* Jeremy R Beitler, MD,d,e Laurent Brochard, Prof, MD,a,f Carolyn S Calfee, Prof, MD,g Niall D Ferguson, Prof,
MD,a,b,c Arthur S Slutsky, Prof, MD,a,f and Daniel Brodie, Prof, MD. COVID-19-associated acute respiratory distress syndrome: is a
different approach to management warranted? Lancet Respir Med. 2020 Aug; 8(8): 816–821.Published online 2020 Jul 6.
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Dr. Shreya E.
MBBS.
Resident in department of Critical Care Medicine.
Manipal hospital Whiteeld.
Mail id: [email protected]
With the arrival of scientic and technological era the focus on holistic care had begun to wane. Fortunately, in the recent times there is
increased awareness about importance of spiritual care in the healthcare and there is a resurgence in incorporating provisions exclusively
for spiritual care in the hospital setting. Hospitals are a stressful environment especially in the critical care and palliative care departments.
Even though recuperation and recovery transpire every day at a hospital, but so does illness, uncertainty and death. These tragedies not only
leave the patient and their family vulnerable but has huge impact on other aspects of patient and family’s life. Illnesses may interrupt
routines, drain nances, separate families create situations of dependency, and lead to an existential and spiritual concern. In this kind of
situation there is a requirement for emotional and spiritual support. This is where the role of spiritual care in hospitals become essential in
helping to navigate through these difcult times.
What is spiritual care?
Many a time people misconstrued that spirituality and religion are identically tantamount. There may be an overlap as religion can be a form
of spirituality, but they are not the same. Spirituality is a fundamental human experience which gives us meaning, hope and purpose in life;
these purposes can vary among individuals, like for some it can be their loved ones, work, music, art, day to day activities, pets, etc. From an
historical perspective there’s always been close association of religion, spirituality and medicine. Ayurveda, the Indian system of medicine,
which had its roots since ancient times, which incorporated the healing of the physical body in addition to the mind.
What are the benets of spiritual care?
Lately there has been growing disconnect between doctor-patient relationship, despite the easier access and newer means of
communication. 1In practice, many practitioners develop apathy and become sceptical due to burnout. We are becoming an individualistic
society. There is a huge demand on us to keep busy, achieve more patient targets, develop our practice, which can sometimes take us away
from our patients. When a patient and their family want to discuss about their anxieties and worries, we usually tend to think it would be
cumbersome or time consuming or wouldn’t know how to respond or that the answer has to be something deep and philosophical. But
research shows that, this is not the case. It is all about the basics – listening, connecting and communication which can be done in the limited
time we have. 2The most basic thing a physician can do is to listen compassionately. Regardless of whether patients are devout in their
spiritual traditions, their beliefs are important to them. By listening, physicians signals their care for their patients, as empathetic listening can
be all the support a patient requires.
On the downside religious involvement and spirituality may adversely affect an individual too. 3For example, religious beliefs may adversely
affect a person’s health by encouraging avoidance or discontinuance of treatments, failure to seek timely medical care, avoidance of effective
preventive health measures and religious abuse. But comparatively the association between spiritual involvement have better health
outcomes. 4 Assessing and integrating patient spirituality into the health care can build trust and rapport, broadening the physician-patient
relationship
Provision of spiritual care in the ICU setting
5Spiritual care is one of the component of palliative care and contributes to the quality of life, 6as per the National Consensus Project and
World health Organization. Many western hospitals have incorporated provisions exclusively for spiritual care in ICU and palliative care. In
the USA there are board certied representatives called Chaplin who are associated with the Institute to provide clergy and other services
irrespective of one religious beliefs. One such model is briey discussed below.
7Spiritual care team (SCT) The model described was developed at Duke University’s Centre for Spirituality, Theology and Health for
implementation in the Adventist Health System:
The goals of a SCT:
1) To identify the spiritual needs of a patient related to medical illness.
2) Competently address those needs.
3) Create an atmosphere where patient’s feel comfortable talking about the spiritual needs to the physician.
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4) To address the whole person need of healthcare team member related to the patient care.
5) To provide a whole person healthcare to all patients they serve.
8All category of patients may benet from spiritual assessment. Examples are- patients with serious, life threatening condition; patients with
chronic disabling medical illnesses; patient with depression or signicant anxiety; patients newly admitted to the hospital or to a nursing
home; and patience being seen for a follow-up out-patient appointment when time is available to address social issues
9Structure of SCT:
1)Physician : is responsible to conduct a brief spiritual assessment in order to identify the spiritual needs.
10Faith, Importance and Inuence, Community, and Address (FICA) Spiritual History Tool, 11HOPE Questions for Spiritual Assessment,
The Open Invite Mnemonic are some of the tools used in Spiritual assessment needs.
The spiritual assessment consist of 3 questions
-Do you have any religious or spiritual support system to help you in the times of need?
-Do you have a religious beliefs that might inuence your medical decision?
-Do you have any other spiritual concern that you would like someone to address?
If the response is yes then the physician will alert the spiritual care coordinator.
2) Spiritual care coordinator: is often a nurse or clinical manager. They review the spiritual assessment and identify and prioritise the spiritual
needs that require addressing. They refer the patient to the Chaplain and later follow up.
3) Chaplain: is a comprehensively trained personnel, to assess and address spiritual need of the patient and develop a spiritual care plan
addressing them along with the type of intervention required. Chaplin also engage in various activities such as listening, counselling, praying,
providing spiritual emotional support to the family members. One of the study in Mayo clinic suggested that over 80% of the patients visited
by a chaplain found the experience signicantly helpful.
The addition of a spiritual care team structure would be difcult in an Indian scenario and would require time. This can be achieved by
education of the trainees and staff. The art of spiritual history taking and on how to handle situation with compassion and care, can be
instilled at medical college level. Without any changes in the structure of educational program it can be established, by teaching medical
students about how to anticipate and be respectful towards others and their religious views despite one's own conviction and beliefs.
Review of evidence of benets with spiritual care
Religious and spiritual coping may have prognostic importance. There are very few studies which have been conducted to evaluate the
benets of Spiritual care. 12Studies have shown that religious and spiritual coping are associated with less depression during illness. One of
the study conducted in Mayo clinic examined the relationship between religious coping and depression among 850 men (aged>65 years)
with no history of mental illness and were hospitalized for a medical illness. Results showed that depressive symptoms were inversely
related to spiritual and religious coping. In addition, spiritual and religious coping was the only baseline variable that predicted less
depression six months later and shown to lessen the ill effects of a stressful life event
Summary
Recently there has been increased awareness about importance of spiritual care in the healthcare. Studies have shown that religious and
spiritual coping are associated with less depression during illness. Many western hospitals have incorporated provisions exclusively for
spiritual care in ICU and palliative care. The addition of a spiritual care team structure would be difcult in an Indian scenario and would
require time. This can be achieved by education of the trainees and staff. The art of spiritual history taking and on how to handle situation
with compassion and care, can be instilled at medical college level. Spiritual care should be a component of comprehensive care provided to
our patients. This may help our patients and their family to endure the impact of illness because sometimes the smallest change can make a
huge difference and enable us to provide holistic care in pursuit of a best medical practice.
Acknowledgements
My sincere gratitude to Dr. Rajesh Mohan Shetty (MHW, Bangalore) for the valuable help and encouraging support.
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References
1. Smith JK, Weaver DB. Capturing medical students' idealism. Ann Fam Med 2006;4:S32-7. [PUBMED] full text
2. https://www.scribd.com/presentation/284245581/Spirituality-and-Health
3. https://www.aafp.org/afp/2012/0915/p546.html and https://www.mayoclinicproceedings.org/article/S0025-6196(11)62799-7/fulltext.
4. https://cmda.org/article/spiritual-assessment-in-clinical-care-part-1/ full text.
5. https://www.atsjournals.org/doi/full/10.1164/rccm.201608-1598ED full text. 1. Wall RJ, Engelberg RA, Gries CJ, Glavan B, Curtis JR.
Spiritual care of families in the intensive care unit. Crit Care Med 2007;35:1084–1090.
6. https://www.sciencedirect.com/science/article/pii/S0885392410003258 full text.
7. Harold G. Koenig, Ted Hamilton, and Kathy Perno. Integrating Spirituality into Patient Care. Durham: Duke University’s Centre for
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11. https://www.aafp.org/afp/2001/0101/p81.html full text
12. https://www.mayoclinicproceedings.org/article/S0025-6196(11)62799-7/fulltext
13. Harold G. Koenig, Dana E. King, and Verna B. Carson. Handbook of Religion and Health, 2nd ed. New York: Oxford University Press,
2012 full text.
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https://www.jpgmonline.com/text.asp?2007/53/4/262/33967 full text.
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16. Harold G. Koenig, Ted Hamilton, and Kathy Perno. Integrating Spirituality into Patient Care; Durham: Duke University’s Center for
Spirituality, Theology and Health, Duke University Medical Center, 2014. Available online: http://www.spiritualityandhealth.duke.edu/
(accessed on 15 September 2014).
17. William D. Winkelman, Katharine Lauderdale, Michael J. Balboni, Andrea C. Phelps, John R. Peteet, Susan D. Block, Lisa A. Kachnic, Tyler
J. VanderWeele, and Tracy A. Balboni. “The relationship of spiritual concerns to the quality of life of advanced cancer patients: Preliminary
ndings.” Journal of Palliative Medicine 14 (2011): 1022–28. Farr A. Curlin, Ryan E. Lawrence, Marshal H. Chin, and John D. Lantos.
“Religion, conscience, and controversial clinical practices.” New England Journal of Medicine 356 (2007): 593–600.
18. Andrea C. Phelps, Paul K. Maciejewski, Mathew Nilsson, Tracy A. Balboni, Alexi A. Wright, M. Elizabeth Paulk, Elizabeth Trice, Deborah
Schrag, John R. Peteet, Susan D. Block, and et al. “Religious coping and use of intensive life-prolonging care near death in patients with
advanced cancer.” Journal of the American Medical Association 301 (2009): 1140–47.
19. Michael J. Balboni, Christina M. Puchalski, and John R. Peteet. “The relationship between medicine, spirituality and religion: three
models for integration.” Journal of Religion and Health 53 (2014): 1586–98.
20 . “Center fo r Sp i r i t ua l i t y, Theo logy and Hea l th , Duke Un i ver s i t y Med i ca l Cen ter. ” Ava i l ab l e on l i ne :
http://www.spiritualityandhealth.duke.edu/ (accessed on 15 September 2014).
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The pandemic of coronavirus disease 2019 (COVID-19) has affected the healthcare system and healthcare workers (HCWs) in
unprecedented manner. When the news of this novel coronavirus rst appeared in January, the HCWs all over the world were more
intrigued by it, yet today almost all countries have been battling it with ebbs and ows. The healthcare systems globally are struggling to put
enough workforce for treatment of increasing number of patients. The stafng problem was further exacerbated due to signicant
proportion of HCWs themselves being infected and unable to work. Lack of enough trained and motivated manpower can be a direct factor
which is linked to higher mortality in case of surge. Furthermore, inadequate manpower leads to sharing of work with remaining HCWs
and/or longer working hours which increases the risk of cross-transmission of infection and burnout among staff. Therefore, provision of an
adequate workforce has been one of the top priorities of healthcare during this pandemic.
The pandemic of COVID-19 has signicant impact on frontline HCWs and their family members. The frontline HCWs went through cycle of
grief with the initial shock and denial to acceptance of the situation. The pandemic was not only a professional challenge for many HCWs, it
involved personal and social sacrices or psychological makeover at many levels. The unrecognised role of HCWs as children to their
parents, or as a spouse or a parent is usually overlooked both by government ofcials and public. Many HCWs have put their profession rst
in this time of need, however at great cost to their personal and family life. The emotional, psychological and mental wellbeing of self and the
family members has additionally been challenged during this time of crisis.
During the start of pandemic, the frontline HCWs, doctors or nurses tried to self-quarantine from their family members to protect them
from exposure. The isolation was not just physical but, in most cases, psychological too because of increased work pressure and distress due
to rapid increase in number of patients and mortality. The hospitals tried to build on infrastructure with increased number of isolation
rooms, and equipment but human resource to manage these increased beds could not be hired and trained on the same scale. This caused
disproportionate increased work with inadequate resources either manpower or PPE. The initial uncertainty in treatment and infection
control aspect of new disease adds to the stress and dilemma. The physical and social distancing took a toll on communication. The
communication failure was not only seen in hospitals but also among HCWs and family or friends. The psycho-social support by family
members is strength in time of crisis, however, social distancing, lockdown and self-quarantine snatched that support to HCWs.
Work-family balance is always challenging for primary caregivers especially working in emergency and intensive care unit (ICU) and this
pandemic has further exacerbated this crisis. There are various aspects unique to this pandemic which challenged the pendulum of work-
family balance of HCWs.
Risk of cross transmission: The frontline HCWs are always at higher risk of cross-transmission because of the virtue of their work and
prolonged exposures with patients of COVID-19. The risk is not limited to HCWs themselves, but also to their close contacts like family
members especially high- risk contacts. The quantication of this risk is difcult which depends on HCWs (like place of work in hospital, and
availability and quality of PPE) and their households (degree of contact and risk factors among family members). Most, studies reported a
higher risk of transmission among frontline HCWs. In a large cohort of 158445 HCWs, the absolute risk of such infections was found low.
However, frontline HCWs and their households had threefold, and twofold increased risk respectively as compared to general population.
The HCWs in intensive care unit (ICU) are not found to have increased risk because of factors like patients admitted in ICU in late phase of
illness with decreasing infectivity and/or better compliance with usage of PPE.
Dr Prashant Nasa
NMC Speciality Hospital, Dubai
Dr Ruchi Nasa
NMC Speciality Hospital, Dubai
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Stigma of Contagion: The HCWs and family members have also faced acts of violence due to the COVID-19 pandemic against the backdrop
of growing social stigma and discriminatory behaviours. There was a false perception and misbelief of public for HCWs their family members
as “vectors of contagion”. The initial lack of reliable information and misinformation especially through social media channels (infodemic)
shaped such beliefs and behaviours among public. This mistrust comes as a further risk to HCWs, who were at frontlines in this public health
emergency.
Psychological distress: The HCWs have faced multiple challenges on working front like inundated systems, shortage of resources like beds,
equipment like ventilators or PPE. There is also psychological impact of this pandemic besides physical challenges. Several studies had
demonstrated, an increased risk of acquiring post traumatic -stress disorder, depression and anxiety among HCWs. Nurse and female
gender were conferred with higher risk of psychological distress. There are various reasons of psychological distress including continuous
exposures to high pressure job, stigma from family members and society, limited social support due to lockdown and lack of psychosocial
help. This distress further threatens the work-family balance of HCWs.
Parenting: Parenting of children in absence of school, group activities, team sports has been a major challenge for parents, with no clarity on
how long the situation will last. The challenges multiply when parents themselves are also caregivers. The children of HCWs, besides the
negative effects of home connement due to school closures, also face lack of emotional support because of working parents. Marriage
among working HCWs is common and crisis multiplies when spouses of HCWs are also on frontline. In most cases, children were left alone
to tend for themselves as the support from day-care centre and schools were disrupted. The relatives or housemaids were also unavailable
during this crisis because of quarantine and lockdown. The effect on children of working HCWs are so far unspoken but likely to be worse
because of added fears and unspoken worries. The old aged parents were similarly isolated in order to reduce the risk of cross-infection and
putting their lives in danger. These all situations were additional mental trauma for the already burdened healthcare professionals.
In conclusion, COVID-19 pandemic is likely to cause long term psychological distress among HCWs and their family members. The balance
of work and family life can only create a motivated workforce which can deal with menace of second or more waves of this pandemic. There
is urgent attention required by government ofcials and healthcare systems on support system of their own staff and their households.
References:
1. Shah ASV, Wood R, Gribben C, Caldwell D, Bishop J, Weir A, et al. Risk of hospital admission with coronavirus disease 2019 in healthcare
workers and their households: nationwide linkage cohort study. BMJ. 2020 Oct 28;371:m3582.
2. Cabarkapa S, Nadjidai SE, Murgier J, Ng CH. The psychological impact of COVID-19 and other viral epidemics on frontline healthcare
workers and ways to address it: A rapid systematic review. Brain Behav Immun Health. 2020 Oct;8:100144.
3. Cluver L, Lachman JM, Sherr L, Wessels I, Krug E, Rakotomalala S, Blight S, Hillis S, Bachman G, Green O, Butchart A, Tomlinson M, Ward
CL, Doubt J, McDonald K. Parenting in a time of COVID-19. Lancet. 2020 Apr 11;395(10231):e64.
4. WHO. Attacks on health care in the context of COVID-19. Updated July 30, 2020. Available at: https://www.who.int/news-
room/feature-stories/detail/attacks-on-health-care-in-the-context-of-covid-19
5. Eyre DW, Lumley SF, O'Donnell D, et al. Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a
prospective observational study. Elife. 2020;9:e60675.
6. van Kampen JJA, van de Vijver DAMC, Fraaij PLA, et al. Shedding of infectious virus in hospitalized patients with coronavirus disease-
2019 (COVID-19): duration and key determinants 2020. Available at :
https://www.medrxiv.org/content/10.1101/2020.06.08.20125310v1.
7. Shaukat N, Ali DM, Razzak J. Physical and mental health impacts of COVID-19 on healthcare workers: a scoping review. Int J Emerg Med.
2020 Jul 20;13(1):40. doi: 10.1186/s12245-020-00299-5.
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Dr. Munta Kartik MD.,IDCC.,EDIC
Sr. Consultant intensivist
Yashoda Hospital,Somajiguda,Hyderabad,Telangana
Transcranial Doppler (TCD) ultrasonography has been described in the literature as an inexpensive, noninvasive method of measuring
blood ow within the cerebral circulation. In modern era it could be described as the doctor’s stethoscope of the brain. Rune Aaslid had
introduced TCD in 1982, which has re invented itself since then to be a reliable diagnostic, monitoring, and therapeutic tool.[1]
Doppler sonography is all about obtaining information regarding blood ow velocities without any structural imaging , but with addition of
tissue imaging it is termed as duplex sonography. Transcranial Doppler is mainly helpful in clinical situations such as assessment of vasospasm,
detection of stenosis of the intracranial arteries, evaluation of cerebrovascular autoregulation, non-invasive estimation of intracranial
pressure and assessment of brain death. [2]
Physics behind Cerebrovascular Hemodynamics:
Ohms law describes the relationship between the three parameters namely Flow, Resistance and Pressure. Flow = Pressure/Resistance
Cerebral blood ow = Cerebral perfusion pressure/Cerebrovascular resistance (CBF = CPP/CVR).[3]
CPP can be obtained from the mean arterial blood pressure and the intracranial pressure (CPP = MAPB-ICP). CVR aids in autoregulation of
blood ow by constriction and dilatation of the arterioles in the cerebral circulation. The Cerebral autoregulation helps in maintaining CBF
stable despite alterations in CPP and CVR, by lowering resistance by inducing vasodilatation to maintain CBF when CPP is decreased and
increasing resistance by vasoconstriction when CPP increases.
Mean ow velocity is directly proportional to ow and inversely proportional to the section of the vessel. Any conditions that leads to a
change in one of these factors can thus affect mean velocity.
Accoustic windows:
Acoustic windows are the specic points of the skull where the cranial bone is thin enough to allow penetration of ultrasound waves. The
main acoustic windows are namely the transtemporal, transorbital, suboccipital windows.
Therefore, familiarity with the anatomic location of cerebral blood vessels relative to the acoustic windows is paramount for measurement
of accurate blood ows.
Figure 1: Accoustic windows and various angles of insonation.
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Preparing to do an Transcranial ultrasound:
The TCD examination can be performed using a 2 MHz frequency ultrasound probe (Figure 2) through the thinner regions of the skull,
termed acoustic windows.
The insonation of cerebral blood vessels can be performed only through these regions of interest.
Specic arteries of the circle of Willis are identied using the following criteria: [4]
(1) relative direction of the probe within a specic acoustic window
(2) direction of blood ow in the interested blood vessel relative to the probe
(3) depth of insonation
Figure 2: Transcranial doppler probe and transtemporal window for insonation.
Trans temporal window:
The transtemporal window is usually the most useful accoustic window. Through this window the Circle of willis can be visualised anterior
to the cerebral peduncles as shown in the gure (gure 3). Cerebral peduncle is visualised as an buttery shaped structure on the ulrasound
image. Through this accoustic window the ICA bifurcation can be identied at depths of 55 to 65 mm.
Figure 3: Trans temporal gray-scale image showing the cerebral peduncles (P) with the echogenic basilar cistern located just anteriorly.
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The MCA, is visualised at depths of 35 to 55 mm, its course runs laterally and slightly anterior from the origin of ICA. Flow in the MCA is
always toward the probe until bifurcation where ow becomes bidirectional.(Figure 4)
The ACA, which can be viewed at depths of 60 to 70 mm, it courses medially and then anteriorly after the ICA bifurcates. The ow in ACA is
always away from the probe.
The PCA can be found at a depth of ~60 to 70 mm. PCA is located usually 1 to 2 cm posterior to the ICA bifurcation, in the same plane as the
circle of Willis. Flow in the proximal PCA (P1 segment) is toward the probe and in the distal PCA (P2 segment) away from the probe. The
velocities in PCA is lower than the velocities of MCA.[5]
Figure 4: Anatomic visualisation of intracranial arteries through the transtemporal window.
Transorbital window
The transorbital window insonates mainly the carotid siphon and the ophthalmic artery. The probe is placed over the closed eyelid after
taking due precautions. The Sonar beam is directed toward the optic canal to insonate the carotid siphon at a depth of 55 to 70 mm. Flow
direction signies the different segments of the siphon. Flow in the ophthalmic artery is always towards the probe.
Suboccipital window
The suboccipital window can be helpful in examination of posterior circulation. It is performed with the neck exed, and can be helpful to
insonate the basilar and vertebral arteries. The basilar artery is typically found at depths of 60 to 70 mm.
Main Clinical Applications:
1. Acute Ischemic Stroke
TCD can detect acute MCA occlusions with high (> 90%) sensitivity, specicity, and positive and negative predictive values.TCD can also
detect occlusion in the ICA siphon, vertebral, and basilar arteries with reasonable (70 to 90%) sensitivity and positive predictive value and
excellent specicity and negative predictive value (> 90%).[6]
TCD ndings play an important role in prognosticating in patients presenting with acute ischemic stroke. CD in acute ischemic stroke can be
helpful where repeated TCD studies can be used to monitor the course of an arterial occlusion before and after performing
thrombolysis.[7]
TCD provides real-time information regarding the direction and the velocity of ow of blood in collateral branches, which are active in acute
and/or chronic steno-occlusive cerebrovascular diseases. It has been observed in studies that the degree of collateral ow is correlated with
infarct volume and clinical outcome in patients with stroke.[8]
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2. Subarachnoid hemorrhage and Vasospasm:
Angiography of the vessels of the brain still remains gold standard for the diagnosis of cerebral vasospasm. However, this procedure is
invasive, requires the availability
of signicant resources.TCD evaluation has been recommended as a screening tool in high-grade WFNS (World Federation of Neurological
Surgeons) scale patients to recognise high risk patients for devoloping vasospasm .[9]
Vasospasm results in elevations of the mean ow velocities in cerebral arteries without any increase in the ow velocities of supplying
extracranial blood vessels.
The utilisation of Lindegaard ratio (LR) to dene the severity of vasospasm by caliculating the ratio between the average mean (Vmean)
velocity of the MCA to ICA helps in differentiating hyperemia from Vasospasm. [10] Hyperemia is diagnosed by incresase in ow velocities in
both the MCA and ICA and result in an LR < 3, whereas Vasospasm usually elevates the MCA ow over the ICA with LR > 6.
TCD is one of the most signicant modalities in monitoring the temporal course of angiographic vasospasm following SAH. It is useful in
timing of diagnostic and therapeutic angiographic interventions.
3. Cerebral Circulatory Arrest
Cerebral ow patterns can be observed and monitored regularly bedside in critically ill neurological patients who are having impending
Cerebro circulatory arrest situations with help of transcranial ultrasound. When the cerebral compliance decreases, ICP increases to match
the diastolic perfusion pressure. It reaches a critical point where diastolic cerebral blood ow approaches zero. With any further rise rise in
ICP, diastolic blood ow starts to reverse in opposite direction, which can be visualized as retrograde ow.[11]
Figure 5: Ultrasound image depicting the reversal of ow pattern in cerebrovascular arrest patient.
The presence of such retrograde or oscillatory diastolic ow along with systolic spikes, is taken as conrmatory sign of cessation of forward
cerebral blood ow and are depictive of CCA.(Figure 5) TCD has very high sensitivity (96.5%) and specicity (100%) in the diagnosis of
cerebral circulatory arrest.
Disadvantages of TCCD:
1. It is operator dependent
2. Sensitivity is 80% when compared to angiography which is around 89-98% for MCA.
3. Viewing structures may prove to be difcult in thick skull individuals.
4. Potential confounders may interfere in appropriate conclusions like the hypo/hypercapnea, Hematocrit, Hypotension etc
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References:
1. Sharma AK, Bathala L, Batra A, Mehndiratta MM, Sharma VK. Ann Indian Acad Neurol. 2016 Jan-Mar; 19(1):102-7.
2. Tsivgoulis G, Alexandrov AV, Sloan MA. Advances in transcranial Doppler ultrasonography. Curr Neurol Neurosci Rep. 2009 Jan;9(1):46-
54.
3. Vriens EM, Kraaier V, Musbach M, Wieneke GH, van Huffelen AC. Transcranial pulsed Doppler measurements of blood velocity in the
middle cerebral artery: reference values at rest and during hyperventilation in healthy volunteers in relation to age and sex. Ultrasound Med
Biol. 1989;15(1):1–8.
4. Tegeler CH, Babikian VL, Gomes CR, editors. Neurosonology. St. Louis, MO: Mosby-Year Book; 1996.
5. Ringelstein EB, Kahlscheuer B, Niggemeyer E, Otis SM. Transcranial Doppler sonography: anatomical landmarks and normal velocity
values. Ultrasound Med Biol. 1990;16(8):745–761.
6. Rasulo FA, De Peri E, Lavinio A. Transcranial Doppler ultrasonography in intensive care. Eur J Anaesthesiol Suppl. 2008;42 (42):167–173.
7. Camerlingo M, Casto L, Censori B, Ferraro B, Gazzaniga GC, Mamoli A. Transcranial Doppler in acute ischemic stroke of the middle
cerebral artery territories. Acta Neurol Scand. 1993;88(2):108–111.
8. Zanette EM, Fieschi C, Bozzao L, et al. Comparison of cerebral angiography and transcranial Doppler sonography in acute stroke. Stroke.
1989;20(7):899–903.
9. Lysakowski C, Walder B, Costanza MC, Tramèr MR. Transcranial Doppler versus angiography in patients with vasospasm due to a
ruptured cerebral aneurysm: A systematic review. Stroke. 2001;32 (10):2292–2298.
10. Lindegaard KF, Nornes H, Bakke SJ, Sorteberg W, Nakstad P. Cerebral vasospasm diagnosis bymeans of angiography and blood velocity
measurements. Acta Neurochir (Wien) 1989;100(1–2):12–24.
11. Tsivgoulis G, Alexandrov AV, Sloan MA. Advances in transcranial Doppler ultrasonography. Curr Neurol Neurosci Rep.
2009;9(1):46–54.
POCUS IN ACUTE KIDNEY INJURY-LEST WE FORGET
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Dr Arjun Alva, MBBS,MDAdministrative Head and Consultant Critical Care Medicine,
Medical Intensive Care Unit,
Consultant incharge Covid ICU, Head of the department,Respiratory therapy care services,
NH-Mazumdar Shaw Multispeciality Hospital,Bangalore.
Email:[email protected] | Mobile:9108026001
Acute Kidney injury has been one of the most common complication in the intensive care unit. There are plethora of factors responsible for
the onset of acute kidney injury (AKI) in the critical care unit. The few of the common causes of acute kidney injury in the ICU include septic
shock, hemodynamically mediated prerenal dysfunction, nephrotoxic drugs, urinary tract obstruction, use of vasopressors and also the
amount and quantity of uids that are used as maintenance or bolus uids. Incidence of acute kidney injury in the intensive care unit is as high
as 60% raising concern regarding Acute kidney injury in the ICU globally with extremely high morbidity. It is also an independent predictor
of mortality.1
We are living in an age of ultrasound and we have spent a lot of time in researching and implementing protocols for evaluation of heart and
lungs. The use of Point of care Ultrasound (POCUS) in evaluating the renal system by intensivists has not been given its due importance.
The pertinent questions which one can get answers through the utility of POCUS in AKI are
1. What mean arterial blood pressure (MAP) is ideal for renal perfusion?
2. Is the patient hypovolemic or hypervolemic?
3. Is renal autoregulation maintained.
4. When do we stop uid resuscitation?
5. Is the patient developing an acute kidney injury?
This article will give a brief into the questions above, which can lay a basic foundation for further research and possible POCUS protocol for
Acute Kidney Injury by discussing the role of ultrasound in calculating Renal Resistive Index and venous excess ultrasound score.
POCUS role in dening intrarenal hemodynamics (RRI)
The renal resistive index (RRI), derived from the doppler spectrum of intrarenal (segmental interlobar) arteries, is obtained by the
difference between maximum and minimum (end-diastolic) ow velocity to maximum ow velocity. RRI = (maximum velocity - minimum
velocity) /maximum velocity. RRI is dependent on the vascular compliance and uid shifts specic to renal system and hence it might give a
true picture of intrarenal hemodynamics.
Renal Resistive index was introduced by Gosling et al in 1974 and has found its utility in prognosis of postrenal transplant patients. Although
the role of RRI has been well documented in critical care areas its clinical application at bedside is yet to gain popularity.
Renal resistive index of more than 0.75 can help in diagnosing onset of acute kidney injury 2 to 3 days before its onset.2 It can also be used to
determine what MAP to be maintained to facilitate renal perfusion.3 As it gives a dynamic index for renal perfusion it is worth pondering on
future studies. In a study done by song et al in septic patients; combining CVP with RRI had a higher prediction of sepsis induced acute kidney
injury.4
Figure 1: The renal resistive index (RRI) is measured by Doppler sonography in an intrarenal interlobar artery, and is the difference between
the peak systolic (PSV) and end diastolic (EDV) blood velocities divided by the peak systolic velocity (PSV)
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Figure 2.5 Different renal and extrarenal determinants concur to determine RRI
Low Renal resistive index i.e IR0.70 in native kidneys are associated with renal dysfunction and adverse cardiovascular issues. In Renal
transplant recipients they are associated with increased risk of graft loss and death.5
POCUS in dening volume status of the patient (VEXUS)
Monitoring the volume status of a patient continues to be a challenge in the critical care units. Peripheral hypervolemic signs have limitations
to the extent that it correlates to only about 52% of the probability of diagnosing volume status. Venous excess ultrasound score (VEXUS)
has been designed with a physiological concept that kidneys being an encapsulated organ, the back-pressure effects are quite prominent.
The hypothesis behind the scoring system is that the IVC gets distended with less than 20% of respiratory variability followed by alteration
of hepatic venous waveform and appearance of portal venous pulsatality.
Ultrasound Assessment:7 Ultrasound assessment is performed bedside using a curvilinear abdominal probe of 8–3 MHz by intensivist who
is experienced in ultrasound examination. The Patients are positioned in the dorsal decubitus position with headend of bed elevated
between 0° and 30°. Hepatic Doppler visualizing either the middle hepatic vein in the subxiphoid area or the right hepatic vein from a lateral
angle is done. Similarly, the portal vein Doppler is interrogated from a lateral approach. As for all Doppler examinations, the waveforms are
traced during a respiratory pause, if respiratory liver movement prevented proper trace generation. The Inferior vena cava(IVC) is
interrogated in long and short axis along the intrahepatic segment and a visual average is done. Respiratory variation is dened as a 20% or
more change in surface area in the short axis.
Grade 0: 20 mm with respiratory variation
Grade IV: >20 mm with minimal or no respiratory variation
Hepatic vein (HV): interrogation by pulsed wave Doppler, identication and analysis of A, S, and D waves:
Grade 0: normal S > D
Grade I: S < D with antegrade S
Grade III: S at or inverted or biphasic trace
S wave is normally the larger of the two negative deections.
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Portal vein Doppler (PD)
Portal vein (PV) interrogation
Grade 0:
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Flowchart for approach to AKI patient 7
In a study done by Beaubien- Souligny et al. in postoperative cardiac surgery patients where a signicant association was found between an
elevated VEXUS score and the development of AKI.6
In a study done by Bhardwaj et al showed that combined imaging of IVC, Hepatic vein and portal vein (VEXUS score) might reliably
demonstrate venous congestion and aid clinical decision-making process in cardiorenal syndrome patients. In this study 87% patients
correlated with resolving AKI and improving VEXUS score.7 This might answer the question whether to aggressively give uids or to give
diuresis more reliably.
In conclusion there is a need for AKI POCUS protocol and a greater emphasis on potential research encompassing renal resistive index and
venous excess ultrasound score to answer some of the key clinical questions by the bedside in management of patients with the risk of acute
kidney injury.
References
1. Maria Boddi et al, Renal Resistive Index and mortality in critical patients with acute kidney injury. Eur J Clin Invest 2016; 46 (3): 242–251
2. Matthieu Le Dorze et al. Renal Doppler Ultrasound: A new tool to assess renal perfusion in critical illness. SHOCK, Vol. 37, No. 4, pp.
360Y365, 2012
3. Nicolas Lerolle et al ,Renal failure in septic shock: predictive value of Doppler-based renal arterial resistive index. Intensive Care Med
(2006) 32:1553–1559 DOI 10.1007/s00134-006-0360-x
4. Ming Zhong, Jieqiong Song et al, Value of the combination of renal resistance index and central venous pressure in the early prediction of
sepsis-induced acute kidney injury. YJCRC (2017) 52885, doi:10.1016/j.jcrc.2018.03.016.
5. Maria Boddi et al , The internist and the renal resistive index: truths and doubts Intern Emergency Med DOI 10.1007/s11739-015-1289-2
6. Beaubien-souligny W,Eliaiek R,Fortier A, Lamarche Y, Liszkowski M, Bouchard J, et al.The association between pulsatile portal ow and
acute kidney injury after cardiac surgery:a retrospective study. J Cardiothoracic Vascular Anesth 2018;32(4):1780-
1787.DOI:10.1053/jvca.2017.11.030
7. Bhardwaj V et al ,Combination of Inferior Vena Cava Diameter, Hepatic Venous Flow, and Portal Vein Pulsatility Index: Venous Excess
Ultrasound Score (VEXUS Score) in Predicting Acute Kidney Injury in Patients with Cardiorenal Syndrome: A Prospective Cohort Study.
Indian J Crit Care Med 2020; https://www.ijccm.org/doi/ IJCCM/pdf/10.5005/jp-journals-10071-23570.
8. Doppler resistive index to reect regulation of renal vascular tone during sepsis and acute kidney injury. Dewitte et al. Critical Care 2012,
16:R165 http://ccforum.com/content/16/5/R165
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Dr Deepak Kumar Nirala
MD. PDCC(Critical care medicine)
Department of Critical Care Medicine, RIMS, Ranchi
Dr Mohd Saif Khan
MD, DNB, PDF (CCM), DM (CCM)
Associate professor
Department of Critical Care Medicine,
RIMS, Ranchi
CRITICAL APPRAISAL:
1. Are the Title and Objectives appropriate?
• Yes, the title is clear and appropriate.
• Objectives of the study are clearly stated.
2. What is the clinical importance of that objective?
• Pregnancy related acute kidney injury (PRAKI) is one of the most important causes of feto-maternal morbidity and mortality.
• In India, PRAKI requiring dialysis was 15% in 1982–1991 and was 10% in 1992–2002.
• The timing of initiation of renal replacement therapy (RRT) for better patient outcome is still debatable with conicting data from different
randomized controlled trials. It will be interesting know the impact of early RRT on fetomaternal outcome.
Was it studied previously and what were the results?
• Wierstra et al. did a Meta analysis on 1042 patients of 9 different studies. Their results were, in “early” RRT group mortality rate was 34.6
% compared with 40.2 % in “late” RRT group. No mortality benet with “early” versus “late” RRT, with an OR of 0.665 (95 % CI
0.384–1.153, p = 0.146). They concluded that “early” initiation of RRT in critical illness complicated by AKI does not improve patient
survival or confer reductions in ICU or hospital LOS.
• Meta-analysis conducted by Bhatt et al. of 10 randomised controlled trials with 1,636 participants, showed no signicant benet of early
RRT on day 30 mortality; day 60 mortality; day 90 mortality [3 trials; 555 participants; RR,0.94];Overall ICU or hospital mortality; dialysis
dependence on day 90. There was no signicant difference between length of ICU or hospital stay and recovery of renal functions.
• Meta-analysis performed by Feng et al. of 9 RCTs with a total of 1636 participants, demonstrated no differences between the early RRT
group and the late RRT with respect to mortality (38% vs 41.4%; relative risk, 0.93). There were no ndings of benets in terms of
reduction in the ICU LOS and hospital LOS.
• In another meta-analysis by Lai et al. showed earlier RRT was not associated with benets in terms of mortality and RRT dependence.
There were also no signicant differences in the ICU and hospital LOS.
3. Do the study design, the variables selected and statistical methods match? Hint: Is it descriptive or analytical? Are Groups being
compared? If so how?
• This is a prospective comparative study in which patients were screened at a multispecialty tertiary-care hospital. RIFLE criteria were
used to dene AKI.
• The demographic prole and clinical characteristics of the patients in terms of age, parity, access to antenatal care, fetal outcome, urine
output, hematological and biochemical proles, RRT, duration of hospitalization, recovery of renal function, and patients survivalwere
recorded.
• The patients were divided into two groups:
• Early RRT (RRT done in 0.05 and signicant if
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5. What were the results?
• This prospective study included 13 patients in the early RRT group and 23 patients in the standard group.
• The age and the weight between the two groups were statistically nonsignicant. The mea