CTMA / DLD-Bio « Academic - Military - Industrial ... · Africa-2 (2011) Planned ... Anthrax : from disease-endemic area to bioterrorism Accidental (benign) ... Terrorism - Risk

CTMA / DLD-Bio

« Academic - Military - Industrial » Interface

EU

Commission

Bio threats

Biomedical

EU Defense

Agency NATO

networks

UCL and CUSL

Academic hospital

CTMA DLD-Bio

EU Space

Agency

Military partners

Integrated Mission Group in Security (IMG-S)

Academic partners In

tera

tion

al

Nati

on

al

Industrial partnership

and valorisation

(SME’s, industries)

Regional / federal

R&D projects

Copyright 2013 - CTMA/DLD-Bio

Civ-Mil cooperation : vision / mission B

io –

Na

no

– IC

T

Iso

latio

n

C

on

ve

rge

nce

CTMA multidisciplinary - multinational R&D Programme

Set-Up multidisciplinary convergence, national and international partnerships

Scientific Expertise

Invention, Patent

Valorisation, Spin-off

Economic value

Civ-Mil transfert of dual Technologies:

CTMA « R&D CBRN-Matrix »

Civ-Mil Joint contribution

BioEDEP,

JIP-CBRN,

CBRN Cat B

COST, PASR,

FP7

Horizon 2020

IAP/ARTES20

Phase-1

Phase-2

EDA

Marshall plan

Biowin, Waleo,

WBHealth

FEDER

Erasmus Mundi

Regional / Federal

R&D projects

BE-MOD

RHID-projects

Interuniv. Attraction

Pole (PIC)

Brain-Belspo

EC

ESA

NATO

IMG-S (CBRN Think tank)

MED

LAND

DLD

BE-Biotech

(SME’s, Industries)

The matrix allows to spread costs, to mutualize the benefits and to decrease the failure rate

CBRN-SIBCRA

Science for Peace & Sec

(SPS)

• CBRN Threats: same issues, shared concerns and some

similiraties in preparedness at the Civ and Mil level

• Observations

– 1: Major biothreat crisis : from « mil » to « civ-mil » cooperation !

– 2: Dual use testing in specialised « reach back » infrastructure

– 3: From «reach back testing » to «on-site testing» !

– 4: Deployability & in-field testing: new constraints and R&D activities !

– 5: How to integrate «space-technologies» and « which ones» ? ,

• Way ahead: Civ-Mil R&D // Ops-tools integrator // Multiuse

Civ-Mil cooperation: the rationale ?

années heures Hours Days Years

Dea

ths

C / E

B C / E

B

Biological agents : Mostly covert incidents with delayed lethality

Impact = (% affected) X (speed of spread)

Risk = Likelihood X Impact

EU Bodies

Industry, Stakeholders, NGO’s, Researchers, Experts, etc.

Member States

(Committees)

CBRN Policy implementation:

a coordinated approach

EU Policies EU Research

DG RTD

Research

DG CNECT

Comm.

JRC

Joint Res.

Centre

DG ENTR

Security DG TAXUD

Border

surveillance

DG MOVE

Transport

DG TRADE

Trade

ECHO

Civil

protection

DG SANCO

Health

Security

Agencies

DG HOME

CBRNE Action

Plan

DG DEVCO

CBRN Centres

Of excellence

EEAS

Ext. security

FPI

Foreign Policy

Instr.

EDA

Defense

(EFC)

DG ENV

Environment

(Seveso)

+ UN Bodies, NATO

DG ENER

Energy

CBRN CoE : Eight Regions

Ukraine /Caucasus (2011)

South East Asia (2010)

Middle East (2011)

Africa -1(2011)

Africa-2 (2011)

Planned

Mediterrean Basin

Central Asia

Protect Recover

Respond Prevent

Deter

Ac

tio

ns

to

un

de

rta

ke

ag

ain

st

cau

ses

Ac

tio

ns t

o u

nd

ert

ak

e

ag

ain

st

eff

ects

Before incident During After incident

CBRN Defence System

PREPAREDNESS /

PLANNING RESPONSE / RECOVERY

DETECTION- MONITORING

- IDENTIFICATION

SITUATIONAL AWARENESS & RESILIENCE

CBRN Life Cycle

CB

RN

In

cid

en

t -

Co

nseq

uen

ces

- C

risis

Man

ag

em

en

t

De

cis

ion

Su

pp

ort

- C

om

mu

nic

ati

on

• CBRN Threats: same issues, shared concerns and some

similiraties in preparedness at the Civ and Mil level

• Observations

– 1: Major biothreat crisis : from « mil » to « civ-mil » cooperation !

– 2: Dual use testing in specialised « reach back » infrastructure



– 5: How to integrate «space-technologies» and « which ones» ? ,


Civ-Mil cooperation: the rationale !

Observation 1

B-threats are a shared « Civ - Mil concern»

Shift from « Mil-WMD» to « Civ-Mil»- R&D prompted by

- Globalization (missions, intercontinental trips…)

- Rapidly emerging diseases

- Risks arise from remote, poorly accessible areas with weak

health care support


Anthrax : from disease-endemic area to bioterrorism

Accidental (benign) human infection

Deliberate release Civ human infection !

Outside «military field» !

Deadly anthrax cases

Countless anthrax copycats

« Weapanized deadly anthrax»

…BUT

White powder – Anthrax BELGACOM towers, Belgium, 11 Jan 2013

http://soirmag.lesoir.be/sites/default/files/652625787_ID3537139_00_reporters_jb6647_009_1_0289J8_0.JPG

From weapons to major natural outbreaks: From Variola to EBOLA and Monkeypox

Smallpox

Viral Hemorraghic

Fever

Biological weapons

Viral Hemorraghic Fevers in Africa : 2012 3 different outbreaks ! Copyright 2012 - CTMA/DLD-Bio


Death rate : 50- 70%

Monkeypox, Chickenpox… or Smallpox ?

Some are very contagious and lethal

Need for rapid differential (Mpx) diagnostic tests !

Common Mil-Civ Needs:

Joint efforts and cooperation

VIRUSES FUNGI PROTOZOAE BACTERIA PRIONS (?)

Challenges: Rapid, specific and sensitive DIM

- Deadly for human beings, animals and crops

- Contaminating the environment

TOXINS

Mitigate CBRN risks : Identification tools and technologies

Alike / Dual !

Intentional release only

CBRN cases

Natural outbreak –

Endemic zone

Daily infections

Hospital – Ops «in-field»

POTENTIAL THREATS OCCASIONAL THREATS COMMON THREATS

Best validation & trg model

NOT EXPECTED in environment

Civ-Mil Concern only if

Terrorism - Risk in war zone (Ops)

PRESENT in natural environment

Civ-Mil Concern

Risk in Epid & endemic area in Ops

COMMON in daily life

Civ-Mil Risk anytime, anywhere

Observation 2

Need for rapid, sensitive, reliable detection and

identification of B-agents

Heavy infrastructure (reach back laboratory)


Genetic-based identification:

Rapid, specific, reproducible, safe !

Skin lesions

Monkeypox – Varicella ?

C+ C-

S1 S2

Fungi?

Observation 3

CBRN threats require « rapid on-site testing»:

The concept «Light Fieldable Laboratory or LiFi »

Size ? Specificity ? Sensitivity ? Type of Samples?

Tools (analytical, communication, GIS/EO, Sat

Navigation [GPS/GNSS], robots) ?

Example of Civ-Mil interface

Light Field Bio-Laboratory for Emergencies

Interoperable platform

for CRBN or Health crisis

Identical HEART

CIVILIAN specifications MILITARY specifications

Common Civ-Mil specifications

– Analytical equipement

– Communication, site selection,

georeferencing

– Expertise (human resources)

– Full CBRN shelter protection

– Heavy shelter, slowly deployable

– Sampling team

– Ops military C2

– B-specific

– Light Fieldable

– First responders (nurses, MD)

– GOARN / WHO / EC DEVCO

Scarce « Ops-certified » structure – funding? Several « Ops-certified » structure – joint

capacity is possible – funding possible !!!

Observation 4 « Increased deployability »and « on-site testing :

New constraints = New R&D field for

« Civ-Mil » CBRN activities»

e.g.,Emerging technologies for rapid identification (Protein, DNA,

RNA, multiplexing, isothermal amplification…);

Biosafety (inactivation of pathogens), reagents lyophilization

Example of Civ-Mil cooperation


Lifi for

Civ-Mil cooperation in Africa ?

240 Km

Monkeypox MWEKA

Outbreaks 2007 & 2008

RESISTANT TUBERCULOSIS

MALARIA

DREPANOCYTOSIS...etc...

EBOLA

Endemic Monkeypox

area

Deployment in Ops

conditions

No dedicated aircraft !

C130 normal rotation: 3days


A simple tent … or even a

wooden hut…..

KUYA KUMPALA CAMP


Light Fieldable Detection Laboratory

Kananga, RDC, April 2009

Modular structure : scalability – joint intervention

Successful monitoring of health-threatening

agents nearby a Military settlement

• Monkeypox outbreak - Submitted for publication;

- Oral presentation, Biodefense conference

congress, München, 22 Oct 2013

• Ebola outbreak

Real-time PCR

• Resistant Tuberculosis

Endpoint-PCR

27

Observation 5

Light fieldable laboratory:

Communication is crucial !

Needs for integrating CBRN and space tech:

How ? Which ones?

Example of Civ-Mil cooperation


29 Integration of Space-based technologies/ tools :

Sat Communications, Sat Navigation (GPS/GNSS), Earth observation (site selection)

Communication between the mobile lab team

the reach back facility and the Ops center ?

– Inter-secure network communication

– Access to distant database

– Information and image transmission

– ….


Copyright 2012 - CTMA/DLD-Bio Copyright 2012 - CTMA/DLD-Bio


B-LiFE

Biological Light Fieldable Laboratory for Emergencies

Proof of Concept 29 Nov 2012

(Anthrax spread in EC premises in Brussels)

Sampling team with smartphones and dedicated applications

Permanent Location

Sampling Process

Alerts Process

Real-Time and smart communication with all necessary parties

Direct connection to central server

Uses all functionalities of last generation phones

Cie CBRN

Bn ….

Copyright 2012- CTMA / DLD-Bio





Georeferencing Samples

& Sampling team

Earth Observation: (a) Site selection Candidate deployment sites 50-500m (b) Sampling team guidance Sat- and phone-guidance

Soccer field RMS


• CBRN Threats at a glance

• Observations

– 1: Major biothreat crisis : from « mil » to « civ-mil » cooperation» !

– 2: Dual use testing in specialised « reach back » infrastucture



– 5: How to integrate «space-technologies» and « which one » ? ,


Civ-Mil cooperation: way ahead !

Integration of other new technologies

• Energy production and consumption

• Type of shelter

• Improved preanalytical steps (sampling,

processing)

• Link between sampling and processing – robots ?

• Reagents (lyophilisation - Ops)

• Biosafety (glovebox, inactivation)

• Communication (secure data transsmission)

• Logistics, Waste…..

37

Deployable laboratory

connected to EU

projects: CBRN matrix

1. FP7-SEC-PRACTICE (2011):

Preparedness and Resilience

against CBRN Terrorism using

Integrated Concepts and

Equipment

2. FP7- SEC-MIRACLE (2013):

MobIle Laboratory for the Rapid

Assessment of CBRN Threats

Located within and outside the EU

(CTMA Coordination )

3. FP7-SEC-EDEN (2013): End-user

driven DEmo for CBRNE

4. FP7-SEC-CAERUS (2014):

Evidence-based policy for post-

crisis stabilisation:bridging the gap

BioEDEP: 2d generation

deployable tactical field

analysis system (project

n°6, phase 1)

EFC

B-LiFE - IAP/ARTES20:

Biological Light Fieldable

laboratory for

Emergencies (CTMA

Coordination)

ESA

EDA

EC-FP7-SEC (CBRN)

CBRN

matrix

CBRN Mil R&D:

Take home message ?

•Mil CBRN Defence capacities are needed … but it

will be difficult to progress as «stand alone» !

•Need for enhanced Civ-Mil joint cooperation –EFC is the “first” craddle….. Not the end !

–ESA and NATO should be part of it !

Due to financial pressure and societal evolution,

survival of “CBRN Mil R&D” implies to meet “wider

societal needs and better EU integration” 38

39

THE END

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CTMA / DLD-Bio « Academic - Military - Industrial ... · Africa-2 (2011) Planned ... Anthrax : from disease-endemic area to bioterrorism Accidental (benign) ... Terrorism - Risk