2007

Tetrazole derivativesR 0310 Cu2(OTf)2-Catalyzed and Microwave-Controlled Preparation of Tetrazoles from

Nitriles and Organic Azides under Mild, Safe Conditions. — 1,5-Disubstituted tet-razoles are synthesized from nitriles and organic azides using catalytic amounts of a soluble Cu(I) catalyst. Under similar conditions with 50—100mol% of catalyst, forma-tion of 1,4-disubstituted tetrazoles predominates. The new procedure is successfully applied to 3'-azido-3'-deoxythymidine providing tetrazole derivative (XV) after depro-tection and deacetylation. — (BOSCH, L.; VILARRASA*, J.; Angew. Chem., Int. Ed. 46 (2007) 21, 3926-3930; Dep. Quim. Org., Univ. Barcelona, E-08028 Barcelona, Spain; Eng.) — S. Adam

36- 116

2007