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New Brunswick fermentors and bioreactors for research through production

Culture success

New Brunswick fermentors and bioreactors by Eppendorf offer:

> A wide range of fermentor and bioreactor products, both stirred tank and packed-bed systems

> 1 - 3,000 Liter capacities, for research, pilot scale or cGMP-compliant production

> Industry-standard and proprietary impellers to meet virtually any culture need

> Set-up and start-up assistance, a comprehensive warranty, as well as a wide range of optional ancillary equipment, product training, validation and support packages

> The combined resources, product portfolios, experience and applications support of New Brunswick and Eppendorf working to offer you a complete process solution, tailored to meet your exact needs

Whether you prefer the convenience of a single-use bioreactor, the flexibility of an autoclavable system, or the robustness of a sterilizable-in-place (SIP) produc-tion-scale reactor, we have a system right for you.

New Brunswick fermentors & bioreactors for all your culture needs

CelliGen® BLUSingle-Use Bioreactor

TOTAL 5.0 - 50.0 LWORKING 1.3 - 40.0 L

S • • • RPC • R orTMFC

3/4Gas

•

BioFlo® / CelliGen® 115Fermentor/Bioreactor

TOTAL 1.3 - 14.0 LWORKING 0.4 - 10.5 L

A • • • • • RPC • R orTMFC

2/3/4Gas

BioFlo® 310Fermentor

TOTAL 2.5 - 14.0 LWORKING 0.8 - 10.5 L

A • • • • • RPC • R orTMFC

2/3/4Gas

•

CelliGen® 310Bioreactor

TOTAL 2.5 - 14.0 LWORKING 0.8 - 10.5 L

A • • • • RPC • R orTMFC

2/3/4Gas

•


TOTAL 7.0 - 19.5 LWORKING 2.0 - 15.5 L

SIP • • • RPC • TMFC 2/3/4Gas

•


TOTAL 19.5 - 40.0 LWORKING 5.2 - 32.0 L

SIP • • RPC/PLC

• R orTMFC

2/3/4Gas

•

CelliGen® 510Bioreactor

TOTAL 19.5 - 40.0 LWORKING 5.2 - 32.0 L

SIP • • • RPC/PLC

• R orTMFC

2/3/4Gas

•


TOTAL 65.0 - 125 LWORKING 13.0 - 100 L

SIP • • • RPC • R orTMFC

1/2Gas

•

BioFlo® ProFermentor

TOTAL 75.0 - 3000 LWORKING 32.0 - 2400 L

SIP • • PLC • R orTMFC

2Gas

•

CelliGen® ProBioreactor

TOTAL 75.0 - 650 LWORKING 18.8 - 520 L

SIP • • • PLC • R orTMFC

4Gas

•

1 Sterilization Methods: S=Single-Use, A=Autoclavable, SIP=Sterilizable-in-Place 2 Controllers: RPC=Reactor Process Controller, PLC=Programmable Logic Controller 3 Air Flow Controllers: R=Rotameter, TMFC=Thermal Mass Flow Controller

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> Designed for high-density cell culture in research or production applications

> Rigid-walled, single-use stirred-tank vessel for proven performance and scalability

> Eliminates vessel autoclaving and cleaning > All vessel components in product contact are made of USP Class VI materials and tested for leachables and extractables

> Available 5.0 L packed-bed vessel: first single-use vessel to feature New Brunswick’s proprietary packed-bed impeller

> Features New Brunswick’s intuitive RPC control software

> Unique non-invasive pH and DO technology > Adaptor kits are now offered to enable your existing New Brunswick, Applikon and Sartorius controller to be used with CelliGen® BLU single-use vessels

> Optional validation packages available > 7 Additional analog input/output connections for local integration of ancillary equipment

CelliGen® BLU Single-Use Bioreactor

5.0, 14.0 & 50.0 L Total Volume

> Versatile entry-level autoclavable system > Pre-programmed with both fermentation and cell culture operating modes for flexibility

> Ability to control up to three independent reactors from a single easy-to-use touchscreen


> 8 Interchangeable vessel options > Precise temperature control provided through heat blanketed vessel (shown above) or water jacketed vessel (shown on the cover)

> Customizable gas flow and mixing options > Available in pre-defined packages for easy ordering, or fully configurable systems to meet specific needs

BioFlo®/CelliGen® 115 Autoclavable Fermentor/Bioreactor

1.3, 3.0, 7.5, & 14.0 L Total Volume

Easy to use — exceedingly versatileSingle-use and autoclavable fermentors and bioreactors

1 2 3 4 5

> Premium autoclavable system, designed for complete versatility and full cGMP compatibility to meet your research and production needs

> Ideal for the growth of virtually any cell line in aerobic or anaerobic environments


> Fully customizable trend screen cascades for data logging and localized process control

> Multiple impellers, gas flow options, redundant probes and more allow ready customization


BioFlo® 310 Fermentor & CelliGen® 310 Bioreactor Autoclavable Benchtop Systems

2.5, 5.0, 7.5 & 14.0 L Total Volume

New Brunswick offers a diverse a range of specialized impellers including:1. Spin Filter (shown with marine blade impeller)2. Cell-Lift Impeller3. Patented Packed-Bed Basket Impeller with draft tube

for use with Fibra-Cel disks (complete impeller as-sembly shown top right)

4. Pitched Blade Impeller5. Marine Blade Impeller > Rushton-type Impeller (not shown)

Fibra-Cel disks are a solid support material used with New Brunswick’s packed-bed bioreactors for growth of mammalian, animal and insect cells, when secreted proteins are desired. Key advantages: > Cell densities averaging 10 times higher than traditional microcarriers, due to protection from shear forces

> Higher mass transfer of nutrients and oxygen > Low pressure drop across the bed for efficient scale-up > Higher surface-to-volume ratios

Unique Impellers and Fibra-Cel® Disk Options Enhance Growth and Productivity

> Unique automated SIP process utilizes only a water supply and the system’s built-in electric heat blanket for sterilization - no external steam supply needed

> Eliminates the need for transferring vessels to the autoclave for sterilization

> Large 38 cm (15 in) fully integrated touchscreen > Features New Brunswick’s intuitive RPC control software

> Fully customizable trend screen for data logging > User-definable cascades for localized process control > Optional validation packages available > 7 Additional analog input/output connections for local integration of ancillary equipment

> ASME rated pressure vessel

BioFlo® 415 Fermentor SIP Benchtop System - Needs No Steam

7.0, 14.0 & 19.5 L Total Volume

> SIP benchtop reactors designed to meet the needs of R&D through production

> Modular design allows for complete system flexibility > Add or remove components pre- or post-delivery > Multiple impeller and gas flow options > Optional Allen Bradley PLC > Features New Brunswick’s intuitive RPC control software

> Integrated load cell for online vessel volume monitoring > Fully automated SIP sequence for sterilization > Optional validation packages available > 7 Additional analog input/output connections for local integration of ancillary equipment


BioFlo® 510 Fermentor & CelliGen® 510 Bioreactor SIP Benchtop System

19.5 & 40 L Total Volume

Industry standards meet flexibilitySterilizable-in-place fermentors and bioreactors

> Mobile skid simplifies transport > Pilot production system without the traditional cost or footprint

> Modular design allows for complete system flexibility > Features New Brunswick’s intuitive RPC control software

> Fully integrated load cell for online vessel volume monitoring



BioFlo® 610 Fermentor SIP System with Integrated Mobile Skid

65 & 125 L Total Volume

> Full adherence to cGMP and GaMP guidelines > Customizable pre- or post-delivery > Multiple validation package offerings > Open piping skid allows for easy accessibility > NEMA-4 rated control cabinet with industry-standard Allen Bradley PLC

> Flush mounted vessel ports for enhanced vessel design and drainability

> Multiple impeller and gas flow options > Optional validation packages available > ASME rated pressure vessel

BioFlo® Pro Fermentor & CelliGen® Pro Bioreactor Modular Customizable SIP systems

BioFlo® Pro: 75 - 3000 L Total Volume CelliGen® Pro: 75 - 650 L Total Volume

RPC Controller — Easy to Use. Lightning-Fast Navigation Between Screens

BioCommand® Software Adds Advanced Control and Monitoring Capability

www.eppendorf.comEppendorf® is a registered trademark and New Brunswick™ is a trademark of Eppendrf AG, Germany. BioFlo®, CelliGen® and BioCommand® are registered trademarks of New Brunswick Scientific Co., Inc., USA. All rights reserved, including graphics and photos. Copyright © 2012 by Eppendorf. Order no. B-1001a

Advanced control made simple

Your local distributor: www.eppendorf.com/worldwide Eppendorf AG · Hamburg · Germany · Tel: +49 40 538 01-0 Application Support E-mail: [email protected] Eppendorf North America, Inc. · USA · Tel: +1 516 334 7500 Toll free phone: +1 800 645 3050 menu option 2 E-mail: [email protected]

New Brunswick’s advanced Reactor Process Control (RPC) is provided as standard on all systems except the Pro line (which uses an Allen Bradley PLC), simplifying transition between systems during scale-up. Control screens are easy to understand and use. > Pre-defined drop-down selections, radio buttons and tabs help you to quickly set up your process

> Quick links at the bottom of each screen make it one-touch simple to navigate between Set-Up, Calibration, Cascade, Pumps and Summary displays

Summary screen displays

all of your critical process

values on one screen for

easy monitoring. View the

setpoint, present value (PV),

current percent output and

control mode for each loop,

as well as cascades you’ve

programmed and unit of

measure

Setup screens let you man-

age connections and operat-

ing modes for each vessel in

your process

New Brunswick’s optional BioCommand® PC-based software automates data logging, provides remote monitoring and control capabilities, and is OPC-compliant, allowing data from other OPC-compatible devices to be integrated into your control strategies. BioCommand® is offered in choice of three packages.

> Track and Trend provides monitoring and historical record keeping, with control of setpoints, alarms and trend dis-plays

> Batch Control helps you optimize your process. It adds equipment lock-out features for security, and recipe fea-tures such as programming and a customizable synoptic display

> For FDA-validated processes choose Batch Control Plus. It adds three levels of security (operator, supervisor and administrator), event logs, audit trails and a database structure to help comply with 21 CFR Part 11 guidelines

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