CURRICULUM VITAE

David M. Ribnicky, Ph.D.

Department of Plant Biology 1005 Route 28

Foran Hall North Branch, NJ 08876

Rutgers University, School of Environmental & Biological Sciences (908) 685-0180

59 Dudley Road (908) 642-3768 cell

New Brunswick, NJ 08901-8520

(848) 932-6365

email: ribnicky@aesop.rutgers.edu

Education

Ph.D. (Botany), University of Maryland, College Park, 1996

B.S. (Honors Botany), University of Michigan, Ann Arbor, 1989

Professional Experience

Research Assistant Professor, Rutgers University, 2015-present

Research Associate, Rutgers University, 2000-2015

Adjunct Professor, Louisiana State University and Pennington Biomedical Research

Center (PBRC), 2005-present

PI of the Botanical Core for an NIH funded Botanical Research Center, 2005 - present

Consultant and Principal Investigator of Botanical Therapautics for Phytomedics, 1998-

2010

Site manager of the TNO gastrointestinal model lab, management team and project team

member 2009 - present

Technical Expert Advisor and Consultant for Pfizer, 2011

Postdoctoral Associate, Rutgers University, 1996-2000

Graduate Research Assistant, University of Maryland, College Park, 1990-1993, 1994-

1996

Graduate Teaching Assistant, University of Maryland, College Park, 1989, l993-1994

Undergraduate Research Assistant, University of Michigan, Ann Arbor, 1989

Undergraduate Teaching Assistant, University of Michigan, Ann Arbor, 1988

Teaching Experience

Mentor for team taught course Advanced Technologies in Biosciences (11:126:444)

2015-2016

Mentor and committee member for an NIH funded T32 training grant with PBRC 2009-

present

Mentor for the SEED program from the American Chemical Society, 1998, 2002-present

Instructor/Advisor for Research in Biotechnology, 2000-2001, 2004-present

Instructor for Rutgers Univ./Univ. of Puerto Rico Internship and Field Course. Project

funded by UDSA, 2001

Instructor for Plant Developmental Biology, 2000

Mentor for Advancements in Science Research for gifted students, 1999-2001, student

was finalist in the Intel Science Research Competition

AgBiotech Informal Seminar, 1997

Introductory Botany (Laboratory), 1994

Plant Physiology (Laboratory), 1993

Introductory Biology (Laboratory), 1989

Introductory Botany (Laboratory), 1988

Research Experience

Development of nutraceuticals and botanical drugs, including establishment of

agricultural and industrial manufacturing protocols and coordination of all toxicological,

preclinical in vitro/in vivo and clinical studies (Rutgers University)

Characterization of the biosynthesis, metabolism and identification of important potential

botanical therapeutic compounds from various species (Rutgers University)

Characterization of the salicylic acid biosynthetic pathway in relation to systemic

acquired resistance in tobacco (Rutgers University)

Development and application of a microassay for the measurement of indole-3-acetic

acid from milligram-sized plant samples using GC-MS-SIM (USDA), this method is

currently being used by the Weyerhauser Company

Developmental studies on embryos from the flowers of Daucus carota (University of

Maryland)

Analytical measurements of auxins using stable isotope dilution technology (USDA)

Initiation, selection and treatment of carrot cell lines to study how auxin relationships

regulate the process of carrot somatic embryogenesis (University of Maryland and

USDA)

Isolation and fixation of carrot protoplasts for flowcytometric analysis as a model system

(NASA project, University of Michigan)

Invited Manuscript Reviewer

Food Chemistry

Bioresource Technology

Journal of Agriculture and Food Chemistry of the American Chemical Society

Australian Journal of Plant Physiology

Plant Growth Regulation

Plant Physiology

Plant Cell

Academic Service

Invited speaker to talk on “The effect of formulation on the bioactivity of Artemisia

preparations for metabolic syndrome” at the 12th

Annual Oxford International Conference

on the Science of Botanicals in Oxford, MS April 15-18, 2013.

Invited speaker to talk about “Botanical Integrity and Gastrointestinal Bioaccessibility” at

the Pennington Scientific Symposium, “Botanicals and Translational Medicine”, in Baton

Rouge, LA February 13, 2013.

Invited speaker to lecture on “Botanicals and Metabolic Syndrome” for the 59th

International Congress and Annual Meeting of the Society for Medicinal Plant and

Natural Product Research in Antalya, Turkey, September 4-9, 2011.

Presented “Effect of carbohydrate matrices on the bioaccessibility and gastric stability of

bioactive botanical compounds for metabolic syndrome using the TNO intestinal model”

at the American Association of Cereal Chemists International annual meeting in Palm

Springs, CA October 16-19, 2011.

Invited speaker to lecture on “Botanicals and Metabolic Syndrome – Botanical Research

Center Projects” for the Penn State Symposium, Prevention of Metabolic Syndrome by

Dietary Phytochemicals - A Symposium on the State of the Science, in October 2010.

Invited speaker to lecture on “The Development of Botanical Therapeutics, from Concept

to Clinic” as part of a Plant Explorer series at Chatham College, Pittsburgh, PA May 2005.

Member of the Conflicts of Interest Committee of Cook College/NJAES 2000-present

Member of the Chaplans Advisory Board for the Episcopal Campus Ministries of Rutgers

University 2001-2007.

Board and executive committee member of the William Alexander Proctor Foundation

2003-2007.

Member of hiring committee for the Chaplan of Rutgers’ Episcopal Campus Ministries

2004.

Awards

Thomas Alva Edison Patent Award from the Research and Development Council of New

Jersey, 2005

Travel Awards from Dept. of Botany at the University of Maryland (1992, 1993)

Travel Award from NSF-ASPP (1991) for the IPGSA Conference in Amsterdam

Jane Prichard Award for excellence in teaching

Research Assistantship at the University of Maryland

Honors Botany degree from the University of Michigan

High-School Valedictorian

Patents

David M. Ribnicky, Moul Dey & Ilya Raskin Anti-inflammatory activity of

phenethylisothiocyanate (PEITC) and the Barbarea verna seed preparation containing

this compound No. 7,838,045 Issued November 23, 2010.

David M. Ribnicky & Ilya Raskin Methods for treating disorders using plant extracts.

European Patent No. 1429602 Issued December 16, 2009.

David M. Ribnicky, Alexander Poulev & Ilya Raskin Recovery of gaultherin and salicylate

derivatives from plants. Issued 2006.

David M. Ribnicky & Ilya Raskin Methods of using Artemisia to treat disorders. Issued 2005.

David M. Ribnicky, Alexander Poulev & Ilya Raskin Phenethyisothiocyanate nutraceutical

compositions and methods. Issued 2001.

Publications

Cheng DM, Roopchand DE, Poulev A, Kuhn P, Armas I, Johnson WD, Oren A, Ribnicky D,

Zelzion E, Bhattacharya D, Raskin I. High phenolics Rutgers Scarlet Lettuce improves glucose

metabolism in high fat diet-induced obese mice. Molecular nutrition& food research. 2016

November;60(11):2367-2378. PubMed PMID: 27529448; PubMed Central PMCID:

PMC5240636.

Obanda DN, Ribnicky D, Yu Y, Stephens J, Cefalu WT. An extract of Urtica dioica L mitigates

obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A).

Sci Rep. 2016 Feb 26;6:22222. PubMed PMID: 26916435; PubMed Central PMCID:

PMC4768183.

Obanda DN, Zhao P, Richard AJ, Ribnicky D, Cefalu WT, Stephens JM. Stinging Nettle (Urtica

dioica L) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an

Adiponectin Dependent Manner. PLoS One. 2016;11(3):e0150252. PubMed PMID: 26939068;

PubMed Central PMCID: PMC4777364.

Aggarwal S, Shailendra G, Ribnicky DM, Burk D, Karki N, Qingxia Wang MS. An extract of

Artemisia dracunculus L stimulates insulin secretion from β cells, activates AMPK and

suppresses inflammation. J Ethnopharmacol. 2015 Jul 21;170:98-105. PubMed PMID:

25980421; PubMed Central PMCID: PMC4470741.

Henagan TM, Cefalu WT, Ribnicky DM, Noland RC, Dunville K, Campbell WW, Stewart LK,

Forney LA, Gettys TW, Chang JS, Morrison CD. In vivo effects of dietary quercetin and

quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin

sensitivity. Genes Nutr. 2015 Jan;10(1):451. doi: 10.1007/s12263-014-0451-1. Epub 2014 Dec

27. PMID: 25542303 [PubMed]

Cefalu WT, Floyd ZE, Stephens JM, Ribnicky DM. Botanicals and translational medicine: a

paradigm shift in research approach. Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S1-3. doi:

10.1016/j.nut.2014.02.009. Epub 2014 Feb 27. No abstract available. PMID: 24985098 [PubMed

- in process]

Vance KM, Ribnicky DM, Rogers RC, Hermann GE. Artemisia santolinifolia enhances

glutamatergic neurotransmission in the nucleus of the solitary tract. Neurosci Lett. 2014 Oct

17;582:115-9. doi: 10.1016/j.neulet.2014.08.048. Epub 2014 Sep 9. PMID: 25220699 [PubMed -

in process]

Ribnicky D.M., Roopchand D.E., Poulev A., Kuhn P., Oren A., Cefalu W.T., Raskin I.

Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability

and hypoglycemic activity in C57BL/6 mice. Nutrition. 2014 Jul-Aug; 30 (7-8 Suppl):S4-10.

doi: 10.1016/j.nut.2014.03.009. Epub 2014 Mar 28. PMID: 24985105 [PubMed - in process]

Richard AJ, Burris TP, Sanchez-Infantes D, Wang Y, Ribnicky DM, Stephens JM. Artemisia

extracts activate PPARγ, promote adipogenesis, and enhance insulin sensitivity in adipose tissue

of obese mice. Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S31-6. doi: 10.1016/j.nut.2014.02.013.

Epub 2014 Mar 12. PMID: 24985103 [PubMed - in process]

Obanda D.N., Ribnicky D., Raskin I., Cefalu W.T. Bioactives of Artemisia dracunculus L.

enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells.

Nutrition. 2014 Jul-Aug;30 (7-8 Suppl):S59-66. doi: 10.1016/j.nut.2014.03.006. Epub 2014 Mar

19. PMID: 24985108 [PubMed - in process]

Fuller S, Richard AJ, Ribnicky DM, Mynatt RL, Beyl R, Stephens JM. St. John's Wort has

metabolically favorable effects on adipocytes in vivo. Evid Based Complement Alternat Med.

2014, Article ID 862575. PMCID: PMC4054923

Richard AJ, Fuller S, Fedorcenco V, Beyl R, Burris TP, Mynatt R, Ribnicky DM, Stephens JM.

Artemisia scoparia enhances adipocyte development and endocrine function in vitro and

enhances insulin action in vivo. PLoS One. 2014 Jun 10;9(6):e98897. doi:

10.1371/journal.pone.0098897. eCollection 2014. PMID: 24915004 [PubMed - in process]

Vance K.M., Ribnicky D.M., Hermann G.E., and Rogers

R.C. St. John’s Wort enhances the

synaptic activity of the nucleus of the solitary tract. Neurosci Lett. 2014 Oct 17;582:115-9. doi:

10.1016/j.neulet.2014.08.048. Epub 2014 Sep 9. PMID: 25220699 [PubMed - in process].

Yu, Y., Zhang, X. H., Ebersole, B., Ribnicky, D., and Wang, Z. Q. Bitter melon extract

attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice.

Scientific Reports, Vol. 3, Article No.: 3142, 2013.

Wicks S, Taylor CM, Luo M, Blanchard E 4th, Ribnicky DM, Cefalu WT, Mynatt RL, Welsh

DA. Artemisia supplementation differentially affects the mucosal and luminal ileal microbiota

of diet-induced obese mice. Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S26-30. doi:

10.1016/j.nut.2014.02.007. Epub 2014 Feb 26. PMID: 24985102 [PubMed - in process]

Ribnicky D.M., Roopchand D.E., Oren A., Grace M., Poulev A., Lila M.A., Havenaar R.,

Raskin I. Effects of a high fat meal matrix and protein complexation on the bioaccessibility of

blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). Food Chem. 2014 Jan

1;142:349-57. doi: 10.1016/j.foodchem.2013.07.073. Epub 2013 Jul 25. PubMed PMID:

24001852.

Boudreau A., Cheng D.M., Ruiz C., Ribnicky D., Allain L., Brassieur C.R., Turnipseed D.P.,

Cefalu1 W.T., Floyd Z.E. Screening Native Botanicals for Bioactivity: An Interdisciplinary

Approach. Nutrition. 2014 Jul-Aug; 30(7-8 Suppl):S11-6. doi: 10.1016/j.nut.2014.02.028. Epub

2014 Mar 15.

Richard, A.J., Amini-Vaughan, Z., Ribnicky, D. M., Stephens, J. M. Naringenin Inhibits

Adipogenesis and Reduces Insulin Sensitivity and Adiponectin Expression in Adipocytes.

Evidence-Based Complementary and Alternative Medicine, Vol. 2013, Article ID 549750, 10

pages, 2013.

A. Speranza, M. G. Corradini, T. G. Hartman, D. Ribnicky, A. Oren, and M. A. Rogers.

Influence of emulsifier structure on lipid bioaccessibility in oil-water nanoemulsions. J. Agric.

Food Chem., Vol. 61, No. 26, pp. 6505-6515, 2013.

Wang, Zh. Q., Zhang, X. H., Yu, Y., Tipton, R. C., Raskin, I., Ribnicky, D., Johnson, W., and

W. T. Cefalu. Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-

induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of

FGF21 pathway. Metabolism, Vol. 62, No. 9, pp. 1239-1249, 2013.

Heather Kirk-Ballard, Zhong Q. Wang, Priyanka Acharya, Xian H. Zhang, Yongmei Yu, Gail

Kilroy, David Ribnicky, William T. Cefalu, Z. Elizabeth Floyd. An Extract of Artemisia

dracunculus L. Inhibits Ubiquitin-Proteasome Activity and Preserves Skeletal Muscle Mass in a

Murine Model of Diabetes. PLOS ONE, February 2013, Volume 8, Issue 2, e57112.

Scherp P, Putluri N, LeBlanc GJ, Wang, ZQ, Zhang XH, Yu, Y, Ribnicky D, Cefalu WT,

Kheterpal I. Proteomic Analysis Reveals Cellular Pathways Regulating Carbohydrate

Metabolism that are Modulated in Primary Human Skeletal Muscle Culture due to Treatment

with Bioactives from Artemisia Dracunculus L. Journal of Proteomics, Accepted manuscript

(unedited version) available online: 26-MAR-2012 DOI information: 10.1016/ j.jprot.

2012.03.024

Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ, Cefalu WT. Bioactives of

Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat

skeletal muscle cells. Diabetes. 2012 Mar;61(3):597-605. Epub 2012 Feb 7.

Rojo, L., Ribnicky, D., Logendra, S., Poulev, A., Rojas, P., Kuhn, P., Dorn, R., Oren, A., Grace,

M. H., Havenaar, R., Lila, M. A., and I. Raskin. Oral administration of anthocyanins from maqui

berry (Aristotelia chinensis) ameliorates hyperglycemia in obese hyperglycemic C57BL/6J mice.

Food Chemistry, Vol. 131, pp. 387-396, 2012

Richard, A.J., Amini, Z., Ribnicky, D.M., and Stephens, J.M. St. John’s Wort inhibits insulin

signaling in murine and human adipocytes. Biochimica et Biophysica Acta. 2012 Apr; 1822

(4):557-63. Epub 2011 Dec 17. PMCID: PMC3294203

Eisenman SW, Poulev A, Struwe L, Raskin I, Ribnicky DM. Qualitative variation of anti-

diabetic compounds in different tarragon (Artemisia dracunculus L.) cytotypes. Fitoterapia 2011

Oct;82(7):1062-74. Epub 2011 Jul 21. PMCID: PMC3164315.

Lila, M.A., Ribnicky, D.M., Rojo, L.E., Rojas-Silva, P., Oren, A., Havenaar, R., Janle, E.M.

Raskin, I., Yousef, G.G., Grace, M.H. Complementary Approaches to Gauge the Bioavailability

and Distribution of Ingested Berry Polyphenolics. J. of Agric. Food Chem. 11-2011.

Buehrer BM, Duffin DJ, Lea-Currie YR, Ribnicky D, Raskin I, Stephens JM, Cefalu WT,

Gimble JM. Tools for the identification of bioactives impacting the metabolic syndrome:

screening of a botanical extract library using subcutaneous and visceral human adipose-derived

stem cell-based assays. J Nutr Biochem. 2011 May 2. [Epub ahead of print]

Wang, ZQ, Yongmei Y., Zhang X.H., Ribnicky D.M., Cefalu W.T. Ecdysterone Enhances

Muscle Insulin Signaling by Modulating Acylcarnitine Profile and Mitochondrial Oxidative

Phosphorylation Complexes In Mice Fed A High-fat Diet. Diabetes. print March 17, 2011, doi:

10.2337/db10-1605

Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, Cefalu WT. Bioactives from

bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in

high-fat diet-fed mice. J Nutr Biochem. 2011 Nov;22(11):1064-73. PMCID: PMC3135761.

Ilnytska O, Stütz

AM, Park-York

M, York

AD, Ribnicky

DM, Zuberi

A, Cefalu

WT,

Argyropoulos G. Molecular mechanisms for activation of the Agouti-related protein and

stimulation of appetite. Diabetes 2011 Jan 60(1):97-106. Epub 2010 Oct 27.

Wang ZQ, Ribnicky DM, Zhang XH, Zuberi A, Raskin I, Yu U, Cefalu WT. An extract of

Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in

skeletal muscle in KKay

mice. J Nutr Biochem 2011 Jan 22(1):71-8. Epub 2010 May 5. PMC

Journal – In Process

Graf, B. L., Raskin, I., Cefalu, W. T., and Ribnicky D. Plant-derived therapeutics for the

treatment of metabolic syndrome. Curr. Opin. Investig. Drugs, No. 11(10), p.p. 1107-1115, 2010.

Watcho P., Stavniichuk R., Ribnicky D.M., Raskin I., Obrosova I.G. (2010) High fat diet-

induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of

Artemisia dracunculus L. Mediators of Inflammation Volume 2010, 1-10 Article ID 268547

Kheterpal I, Coleman L, Ku G, Wang ZQ, Ribnicky D, Cefalu WT. Regulation of insulin action

by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture – a

proteomics approach. Phytother Res 2010 Sep 24(9):1278-84. PMC Journal – In Process

Cefalu WT, Stephens J, Ribnicky DM. Botanicals in the Prevention and adjunctive treatment

for Type 2 Diabetes. In: Herbal Medicine: Biomolecular and Clinical Aspects (a volume in the

Oxidative Stress & Disease Series) (Benzie I, Wachtel-Galor S, eds.), Taylor & Francis, Oxford,

UK, 2010 (In Press). Book chapter, no PMCID needed

Amini ZJ, Boyd B, Doucet JA, Ribnicky DM, Stephens JM. St. John's Wort inhibits adipocyte

differentiation and induces insulin resistance in adipocytes. Biochem Biophys Res Commun

2009 388:146–149. PMC Journal – in Process

Kellogg J, Ribnicky D, Wang J, Flint C, Kuhn P, Raskin I, Lila MA. Alaskan wild berry

resources and human health under the cloud of climate change. J Agric Food Chem 2010 Apr 14

58(7):3884-900. NIHMS# 161682

Cefalu WT, Ribnicky DM. Modulation of Insulin Action by Botanical Therapeutics. Obesity

and Weight Management. December 2009, 5(6): 277-281. doi:10.1089/obe.2009.0604. PMC

Journal – In Process

Ribnicky DM, Kuhn P, Poulev A, Logendra S, Zuberi A, Cefalu WT, Raskin I. Improved

absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia

dracunculus L. Int J Pharm 2009 370(1-2):87-92. PMC Journal – In Process

Stewart LK, Wang Z, Ribnicky DM, Soileau JL, Cefalu WT, Gettys TW. Failure of dietary

quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice

during the development of diet-induced obesity. Diabetologia 2009 Mar 52(3):514-523. PMCID:

PMC2758024

Mary H. Grace, David M. Ribnicky, Peter Kuhn, Alexander Poulev, Sithes Logendra Gad G.

Yousef, Ilya Raskin, Mary Ann Lila (2009) Hypoglycemic activity of a novel anthocyanin-rich

formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytochemistry 2009

May 16(5): 406–415. doi:10.1016/j.phymed.2009.02.018.

Barbara Schmidt, David M Ribnicky, Alexander Poulev, Sithes Logendra, William T Cefalu

and Ilya Raskin (2008) A Natural History of Botanical Therapeutics. Metabolism 57 (Suppl 1)

S3-9

Heather Kirk, William T. Cefalu, David Ribnicky, Zhijun Liu, Kenneth J. Eilertsen (2008)

Botanicals as Epigenetic-Modulators for mechanisms contributing to development of Metabolic

Syndrome. Metabolism 57 (Suppl 1) S16-23

Ralf Jager, Iain P Kendrick, Martin Purpura, Roger Harris, David M. Ribnicky, Ivo Pischel

(2008) The effect of Russian tarragon (Artemisia dracunculus L.) on the plasma creatine

concentration with creatine monohydrate administration. International Society of Sports

Nutrition 5 (Suppl 1): 4

Laura K. Stewart, Ph.D, Jeff L. Soileau, David Ribnicky, Zhong Q. Wang, IIya Raskin,

Alexander Poulev, Martin Majewski, William T. Cefalu, and Thomas W. Gettys, Ph.D. (2008)

Quercetin transiently increases energy expenditure and decreases circulating markers of

inflammation in C57BL/6J mice fed a high fat diet. Metabolism 57 (Suppl 1) S39-46

Wang ZQ, Zhang X, Ribnicky DM, Raskin I, Cefalu WT (2008) Bioactives of Artemisia

dracunculus L. enhance cellular insulin signaling in primary human skeletal muscle culture.

Metabolism 57 (Suppl 1) S58-64

Burns Kraft, T.F., M. Dey, R.B. Rogers, D.M. Ribnicky, D.M. Gipp, W.T. Cefalu, I. Raskin,

M.A. Lila. (2008) Phytochemical composition and metabolic performance enhancing activity of

dietary berries traditionally used by Native North Americans. J. Food Chem. 56:654-660

Cefalu, W.T., J. Ye, A. Zuberi, D.M. Ribnicky, I. Raskin, Z. Liu, Z.Q. Wang, P.J Brantley, L.

Howard, M. Lefevre. (2008) Botanicals and metabolic syndrome. Am. J. Clin Nutr

87(suppl):481S-487S

Ribnicky, D.M., A. Poulev, B. Schmidt, W.T. Cefalu, I. Raskin (2008) Evaluation of botanicals

for improving human health. Am. J. Clin Nutr 87(suppl):472S-475S

Barbara M. Schmidt, David. M. Ribnicky, Moul Dey, Peter E. Lipsky, and Ilya Raskin (2007)

Botanical Therapeutics: New Life for an Ancient Concept Nature Chemical Biology 3: 360-366.

Dmitry Govorko, Sithes Logendra, Yanxin Wang, David Ribnicky, Alex Poulev, Ilya Raskin

(2007) Polyphenolic Compounds from Artemisia dracunculus L. Inhibit PEPCK Gene

Expression and Gluconeogenesis in an H4IIE Hepatoma Cell Line Am J Physiol End and

Metabolism 293(6): E1503-10

Sithes Logendra, David M Ribnicky, Hui Yang, Alexander Poulev, Jun Ma, Edward J Kennelly,

Ilya Raskin (2006) Bioassay-guided isolation of aldose reductase inhibitors from Artemisia

dracunculus. Phytochemistry, 67: 1539-1546

Dey M, Ribnicky D, Kurmukov AG and Ilya Raskin (2006) Transcriptional modulation and in

vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate. Journal

of Pharmacology and Experimental Therapeutics, 317(1):326-33.

David M. Ribnicky, Alexander Poulev, Malcolm Watford, William T. Cefalu, Ilya Raskin

(2006) Antihyperglycemic Activity of TARRALIN™, an Ethanolic Extract of Artemisia

dracunculus L. Phytomedicine, 13: 550-557

David M. Ribnicky, Alexander Poulev, Ralf Jaeger & Ilya Raskin (2004) Toxicological

evaluation of Artemisia dracunculus L. extract. Journal of Food and Chemical Toxicology 42:

585-598

David M. Ribnicky, Alexander Poulev & Ilya Raskin (2003) The determination of salicylates in

Gaultheria procumbens for use as a natural aspirin alternative. Journal of Nutraceuticals,

Functional and Medical Foods 4(1): 39-51

Ilya Raskin, David M. Ribnicky, Slavko Komarnytsky, Nebojsa Iliç, Alexander Poulev, Nikolai

Borisjuk, Anita Brinker, Diego A. Moreno, Christophe Ripoll, Nir Yakoby, Joseph M. O'Neal,

Teresa Cornwell, Ira Pastor and Bertold Fridlender. Plants and human health in the twenty-first

century. Trends in Biotechnology, 2002, 20:12:522-531

David M. Ribnicky, W.-S Hu, Jerry D. Cohen & Todd J. Cooke (2002) An auxin surge

following fertilization in carrot: a plausible mechanism for regulating plant totipotency. Planta

214: 505-509

David M. Ribnicky, Alexander Poulev, Eve Henry & Ilya Raskin (2001) Seed of Barbarea

verna as a rich source of phenethyl isothiocyanate to provide natural protection from

environmental and dietary toxins. Journal of Nutraceuticals, Functional and Medical Foods 3(3):

43-65

Cary Leizer, David Ribnicky, Alex Poulev, Slavik Dushenkov & Ilya Raskin (2000) The

composition of hemp seed oil and its potential as an important source of nutrition. Journal of

Nutraceuticals, Functional and Medical Foods: 2(4)35-53

David M. Ribnicky, Vladimir Shulaev & Ilya Raskin (1998) Intermediates of salicylic acid

biosynthesis in tobacco. Plant Physiol 118: 565-572

David M. Ribnicky, Jerry D. Cohen & Todd J. Cooke (1998) Microscale analysis of free and

conjugated indole-3-acetic acid in milligram amounts of plant tissue using a benchtop gas

chromatograph-mass spectrometer. Planta 204: 1-7

Michele Barker-Bridgers, David M. Ribnicky, Jerry Cohen and Alan M. Jones. Red light-

regulated growth. Changes in the abundance of indoleacetic acid in the maize (Zea mays

L.)mesocotyl. Planta 204: 207-211

David M. Ribnicky, Nebojsa Ilic, Jerry D. Cohen and Todd J. Cooke (1996) The effects of

exogenous auxins on endogenous indole-3-acetic acid metabolism. Plant Physiol 112: 549-558

Jerry D. Cohen, Janet P. Slovin, Kristina Bialek, Ellen G. Sutter, Bruce G. Baldi, Lech

Michalczuk, David M. Ribnicky, Yuen Yee Tam & Todd J. Cooke (1992) Stable isotope

techniques for the analysis of indole auxin metabolism in normal and mutant plants. In C.M.

Karssen, L.C. Van Loon & D. Vreugdenhil, eds, Progess in Plant Growth Regulation, Kluwer

Academic Publishers, Dordrecht, The Netherlands, pp 859-873

Lech Michalczuk, David M Ribnicky, Todd J. Cooke & Jerry D. Cohen (1992) Regulation of

indole-3-acetic acid biosynthetic pathways in carrot cell cultures. Plant Physiol 100: 1346-1353

Abstracts

Tara M. Henagan, Laura K. Stewart, David Ribnicky, Robert C. Noland, Laura Forney, Thomas

W. Gettys and William T. Cefalu. Quercetin and red onion extract attenuate high fat diet-

induced insulin resistance while increasing energy expenditure and skeletal muscle

mitochondrial number despite a decrease in Pgc1a. Experimental Biology. April 2014.

Ribnicky D.M., Poulev A., Kuhn P., Roopchand D., Oren A., Grace M.H., Yousef G.G.,

Havenaar R., Lila M.A., Cefalu W. T., Raskin I. Effect of carbohydrate matrices on the

bioaccessibility and gastric stability of bioactive botanical compounds for metabolic syndrome

using the TNO intestinal model. Annual Meeting of the American Association of Cereal

Chemists International. October 2011.

Obanda D. N., Ribnicky, D.M., Wang, Z.Q., Cefalu, W.T. Mitigating Ceramide Induced Insulin

Resistance in Rat Skeletal Muscle Culture Using Bioactives of Artemisia dracunculus L.

American Diabetes Association, 71st Annual Scientific Session. June 2011.

David Ribnicky, Alexander Poulev, Peter Kuhn, Sithes Logendra, Aamir Zuberi, William

Cefalu, Ilya Raskin Bioavailability assessment of an extract of Artemisia dracunculus L with

antidiabetic activities in vitro and in vivo (2007) 67th

Scientific Sessions of the American

Diabetes Association, June 22-26, Chicago IL

Leslie S. Son, Jianhua Qin, Zhong Q Wang,, Xian Zhang, David M Ribnicky, William T Cefalu

Effect of an active fraction of Artemisia dracunculus L. on cellular insulin signaling in Primary

Human Skeletal Muscle Culture. (2007) 67th Scientific Sessions of the American Diabetes

Association, June 22-26, Chicago IL

Ann A Coulter AA, George Agyropoulos, David M Ribnicky, Xian Zhang, Zhong Q Wang,

William T Cefalu Reduction in PTP-1B Protein Levels in Skeletal Muscle by an alcoholic

extract of Artemisia dracunculus L.is phenotype dependent. (2007) 67th

Scientific Sessions of

the American Diabetes Association, June 22-26, Chicago IL

Zhong Q Wang, David M Ribnicky, Aamir Zuberi, Xian Wang, Xin Ye, Jainhua Qin, Leslie

Son, Ilya Raskin, Willian T Cefalu An Extract Of Artemisia Dracunculus L. Increases Insulin

Sensitivity And Enhances Cellular Insulin Signaling In Kkay Mice. (2007) 67th

Scientific

Sessions of the American Diabetes Association, June 22-26, Chicago IL

Zhong Wang, David Ribnicky, Sithes Logendra, Alexander Poulev, Jun Ma, Hui Yang, Edward

Kennelly, Xiaotuan Liu, Ilya Raskin & William T Cefalu. Bioactives from an extract of

Artemisia dracunculus L. exhibit potent inhibitory activities for PTB1B in human skeletal

muscle culture. (2006) 66th

Scientific Sessions of the American Diabetes Association, June 9-

13, Washington D.C.

Olga Dubuisson, Jacalyn Macgowan, David Ribnicky, Ilya Raskin, William T Cefalu & Aamir

Zuberi. Hypoglycemic and hypoinsulinemic effects of a dietary supplement, Artemisia

dracunculus (Russian Tarragon), in obese and diabetic mice. (2006) 66th

Scientific Sessions of

the American Diabetes Association, June 9-13, Washington D.C.

Michael Lefevre, Zhong Wang, David Ribnicky, Ilya Raskin Xian Zhang, Matthew Hulver,

Anthony Civitarese, Jianping Ye & William Cefalu. Use of hierarchical cluster analysis to

prioritize secondary screening of bioactive botanicals for treatment of insulin resistance. (2006)

66th

Scientific Sessions of the American Diabetes Association, June 9-13, Washington D.C.

Dimitry Govorko, Sithes Logendra, David Ribnicky, Alexander Poulev, Jun Ma, Hui Yang,

Edward Kennelly &, Ilya Raskin. Bioactivity-guided isolation of anti-diabetic compounds from

an extract of Artemisia dracunculus L. using a novel PEPCK gene expression assay. (2006) 66th

Scientific Sessions of the American Diabetes Association, June 9-13, Washington D.C.

Sithes Logendra, David Ribnicky, Alexander Poulev, Jun Ma, Hui Yang, Edward Kennelly &,

Ilya Raskin. Isolation of novel inhibitors of human aldose reductase activity from an anti-

diabetic extract of Artemisia dracunculus L. (2006) 66th

Scientific Sessions of the American

Diabetes Association, June 9-13, Washington D.C.

Dey, M, Ribnicky D, Kurmukov AG, Raskin I (2006) Phenethylisothiocyanate from Barbarea

verna as anti-inflammatory agent. Experimental Biology meeting, April 1-5, San Francisco, CA,

USA_; Abstract #121.

Ilya Raskin and David Ribnicky. Phenethyl isothiocyanate (PEITC)- a secondary antioxidant

with unique pharmacological activities. (2005) American Chemical Society Division of

Agricultural and Food Chemistry.

Diane Harris, Jim Arteaga, Anne Muro, Navindra Seeram, Ron Irwin, Andra Lembertas, Ilya

Raskin, David Ribnicky and David Heber (2005) Comparative effects of phenethyl

isothiocyanate (PEITC) and an extract of upland cress (Barbarea verna) seed on intestinal

tumorigenesis in vivo. American Association for Cancer Research, Anaheim California

David M Ribnicky, Alexander Poulev, Sithes Logendra, William T Cefalu, Zhong Wang and

Ilya Raskin (2005) The Development of an Extract of Artemisia dracunculus L. for decreasing

the insulin resistance associated with diabetes, from concept to clinic. Gordon Research

Conference on Agricultural Sciences, Adding More Value to Production Agriculture, February

13-18, Ventura, California.

David M. Ribnicky, Alexander Poulev, Malcolm Watford, Zhong Q Wong, Ilya Raskin (2004)

The effect of TarralinTM

, an extract of Artemisia dracunculus L., on blood glucose parameters in

diabetic animal models. Abstract for the 64th

session of the American Diabetes Association

Zhong Wang, Xian M Zhang, David M Ribnicky, and William T Cefalu (2004) Effect of an

alcoholic extract of Artemisia dracunculus (TarralinTM

) on glucose uptake in human skeletal

muscle culture. Abstract for the 64th

session of the American Diabetes Association

David M. Ribnicky, Alexander Poulev & Ilya Raskin Development of PMI-5001, a Natural

Salicylate from Gaultheria procumbens for Cardiovascular Health. (2002) Abstract for

Advances in Therapeutic Agents Discovery and Development, the proceedings of a Rutgers

University/Industry workshop

David M. Ribnicky, Ilan Chet, Iris Yedidya, Dana Frisem, Alexander Poulev, & Ilya Raskin

(2001) Extracts of Gaultheria procumbens L. promote disease resistance in Cucumis sativus

challenged with Pseudomonas syringae pv. Lachrymans. Abstract for the Annual Meeting of the

American Society of Plant Biologists

David M. Ribnicky, Alexander Poulev, & Ilya Raskin (1999) Determination of salicylates in

Gaultheria procumbens using by LC-MS and GC-MS. Abstract for the Annual Meeting of the

American Society of Plant Physiologists.

David M. Ribnicky, Vladimir Shulaev & Ilya Raskin (1997) Benzaldehyde as an intermediate

in salicylic acid biosynthesis in tobacco. Abstract for the Annual Meeting of the American

Society of Plant Physiologists.

David M. Ribnicky, Jerry D. Cohen & Todd J. Cooke (1996) The role of auxin in carrot

zygotic embryogenesis. Abstract for the Annual Meeting of the American Society of Plant

Physiologists.

Michele Barker-Bridgers, Alan M. Jones, David M. Ribnicky, Terri L. Lomax and Jerry D.

Cohen (1996) The diageotropica phenotype - is it a result of auxin conjugation? Abstract for the

Annual Meeting of the American Society of Plant Physiologists.

David M. Ribnicky, Jerry D. Cohen & Todd J. Cooke (1995) Microscale analysis of free and

conjugated IAA by GC-MS-SIM. Abstract for the Annual Meeting of the American Society of

Plant Physiologists.

David M. Ribnicky, Jerry D. Cohen & Todd J. Cooke (1995) A microtechnique for the analysis

of free and conjugated IAA by GC-MS-SIM. Abstract for 15th International Conference on Plant

Growth Substances.

Michele Barker-Bridgers, Alan M. Jones, David M. Ribnicky & Jerry D. Cohen (1995) Red

light causes auxin to decrease preferentially within the epidermis of the maize mesocotyl.

Abstract for the Annual Meeting of the American Society of Plant Physiologists.

Jerry D. Cohen, Janet P. Slovin, David M. Ribnicky, Carol Auer, Gary A. Kuleck, Yuen Yee

Tam, and Todd J. Cooke (1994) Hormone metabolism during plant regeneration from culture.

Research on Plant Growth Substances (a post-lBC symposium on plant hormones), Univ. of

Tokyo, Japan Abstract pp.5-6.

David M. Ribnicky, Jerry D. Cohen & Todd J. Cooke (1993) Control of auxin metabolism in

relation to carrot somatic embryogenesis. Abstract for the Annual Meeting of the American

Society of Plant Physiologists

David M. Ribnicky, Lech Michalczuk, Jerry D. Cohen & Todd J. Cooke (1992) Auxin

metabolism of carrot somatic embryogenesis. Abstract for the Annual Meeting of the American

Society of Plant Physiologists

David M. Ribnicky, Lech Michalczuk, Jerry D. Cohen & Todd J. Cooke (1991) Auxin

relationships during carrot somatic embryogenesis. Abstract for the 14th International

Conference on Plant Growth Substances