CURRICULUM VITAE David Randal Hessl, Ph.D. · 2017. 5. 26. · CURRICULUM VITAE David Randal Hessl, Ph.D. Department of Psychiatry and Behavioral Sciences and MIND Institute University

CURRICULUM VITAE

David Randal Hessl, Ph.D.

Department of Psychiatry and Behavioral Sciences and

MIND Institute

University of California Davis Medical Center

2825 50th

Street

Sacramento, CA 95817

(916) 703-0249

[email protected]

EDUCATION

Ph.D. University of Washington. Seattle, WA (1997)

Major Area: Child Clinical Psychology

Minor Area: Developmental Psychology

Advisor: Geraldine Dawson, Ph.D.

M.S. University of Washington. Seattle, WA (1995)

Major Area: Child Clinical Psychology

B.A. University of California, Los Angeles. Los Angeles, CA (1989)

Major: Psychology

ADDITIONAL TRAINING

1996 – 1997 APA Accredited Internship. Lucile Salter Packard Children’s Hospital

at Stanford and The Children’s Health Council Consortium, Stanford and

Palo Alto, CA.

1997 - 1998 MacArthur Foundation Post-Doctoral Fellowship. Institute of Human

Development, University of California, Berkeley, CA.

ACADEMIC POSITIONS

2014 – present Professor of Clinical Psychiatry. Department of Psychiatry and

Behavioral Sciences and MIND Institute, University of California Davis

School of Medicine, Sacramento, CA.

2008 – 2014 Associate Professor of Clinical Psychiatry. Department of Psychiatry

and Behavioral Sciences and MIND Institute, University of California

Davis School of Medicine, Sacramento, CA.

David R. Hessl, PhD, 2

2006 – 2008 Assistant Professor of Clinical Psychiatry. Department of Psychiatry

and Behavioral Sciences and MIND Institute, University of California

Davis School of Medicine, Sacramento, CA.

2003 – 2006 Assistant Clinical Professor. Department of Psychiatry and Behavioral

Sciences and MIND Institute, University of California Davis School of

Medicine, Sacramento, CA.

2002 – 2003 Psychologist II. MIND Institute, University of California Davis School

of Medicine, Sacramento, CA.

1998 - 2001 Research and Clinical Psychologist. Behavioral Neurogenetics Research

Center, Division of Child Psychiatry, Stanford University School of

Medicine, Stanford, CA.

ACADEMIC AWARDS AND FELLOWSHIPS

1988 Honors in Psychology, University of California, Los Angeles

1991-1996 NIMH Graduate Student Research Fellowship, University of Washington

1994 Department of Psychology Dissertation Award, University of Washington

1997-1998 MacArthur Foundation Post-Doctoral Fellowship, Institute of Human

Development, University of California, Berkeley

2003 Joe P. Tupin Research Award, Department of Psychiatry, U.C. Davis

2004 Co-Recipient, National Fragile X Foundation Hagerman Award, for

contribution to the discovery of Fragile X-Associated Tremor/Ataxia

Syndrome

2006 U.C. Davis Imaging Research Center Award

2007-2008 MIND Institute Pilot Research Grant Award

2008 U.C. Davis Academic Senate Research Travel Award

2008 U.C. Davis finalist – John Merck Scholars Program, Biology of

Developmental Disabilities in Children

2009 Dean’s Team Award for Excellence, U.C. Davis School of Medicine

2012 Jarrett Cole Clinical Award, National Fragile X Foundation, for

“Dedicated Service to Families in the Worldwide Fragile X Community”

COMMITTEES AND SERVICE

2004 - Member, Human Development Graduate Group, UC Davis

2009 - Scientific and Clinical Advisory Board, National Fragile X Foundation

2008 - 2011 Member, Admissions Committee, U.C. Davis School of Medicine

2011 - 2014 Member, Committee on Student Progress, U.C. Davis School of Medicine

2008 - 2010 Co-Chair, Interview Subcommittee, Admissions Committee, U.C. Davis

School of Medicine


2009 University of California, Davis Health System Centennial Event Panelist,

Cornell Club, New York, NY and Capitol Visitor Center, Washington, DC

2010 - 2012 Member, Town Hall Committee, MIND Institute, U.C. Davis

2010 - 2011 Member, Research IV Planning Committee, U.C. Davis School of

Medicine

2011 - 2014 Member, Committee on Student Progress, U.C. Davis School of Medicine

2013 - Specialty Advisor, UC Davis School of Medicine

2014 - 2015 Member, Committee on Research, UC Davis School of Medicine

2014 - Member, Clinical Trials Committee, Fragile X Clinical and Research

Consortium

2015 - Member, Neuroscience Graduate Group, UC Davis

2015 Special Emphasis Panel, Centers for Disease Control and Prevention,

“Using Longitudinal Data to Characterize the Natural History of Fragile X

Syndrome to Improve Services and Outcomes”

2014 - Faculty Mentor, MIND Institute International Training Program in

Neurodevelopmental Disorders (ITPND), UC Davis

2016 Ad Hoc Reviewer, Board of Scientific Counselors, National Institute of

Mental Health

2016 - Faculty Welfare Committee, UC Davis

2016 - Child and Family Care Administrative Advisory Committee, UC Davis

PANELS AND ADVISORY POSITIONS

Member, Adolescents and Adults Projects Team, National Fragile X Foundation

Reviewer, Social Sciences and Humanities Research Council of Canada

Member, NIH Fragile X Research Coordinating Group

Member, Fragile X Clinical & Research Consortium Executive Council

Advisory Panelist, NICHD Outcome Measures for Clinical Trials with Children with Fragile X

Syndrome

Invited Participant, NIH Research Plan for Fragile X Syndrome and Associated Disorders (2008)

Panelist, “How to Develop an Interdisciplinary Program of Research”, NIH Interdisciplinary

Training Conference on Developmental Disabilities, Annapolis, MD

Invited Participant, NIH Research Plan for Fragile X Syndrome and Associated Disorders (2012)

Clinical Trials Consultant, Hoffman LaRoche

Clinical Trials Consultant, Novartis

Clinical Trials Consultant, Seaside Therapeutics

Invited Expert Panelist, “The Future of Fragile X: Center for Disease Control Public Health

Research Agenda”, Atlanta (2014)

COMMUNITY SERVICE

“A Conversation Between a Researcher and a Parent of a Child with Autism”, Access To Care,

Bayside Church, Roseville, CA


Donation of an in-home evaluation of a child with fragile X syndrome in Iowa, to benefit the

National Fragile X Foundation, 2007

Donation of an in-home evaluation of two children with fragile X syndrome in Missouri, to

benefit the National Fragile X Foundation, 2008

Donation of an in-home evaluation a child with fragile X syndrome in Mississippi, to benefit the

National Fragile X Foundation, 2011

Provided consultation in an autism clinic, in association with the First Annual Autism

Conference, Dubai, United Arab Emirates, 2005

ACADEMIC PROFESSIONAL SERVICE

Editorial Board Member – Journal of Neurodevelopmental Disorders

Co-Editor, Special Issue on Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) – The Clinical

Neuropsychologist (2016)

Ad Hoc Reviewer

Acta Psychiatrica Scandinavica

American Journal on Intellectual and Developmental Disabilities

American Journal of Medical Genetics Part B:Neuropsychiatric Genetics

American Journal of Psychiatry

Annals of Neurology

Autism Research

Behavior Genetics

Behavioral Brain Research

Brain and Cognition

Clinical Genetics

Genes, Brain and Behavior

Biological Psychiatry

Child Development

Development and Psychopathology

International Journal of Psychophysiology

Journal of Autism and Developmental Disorders

Journal of Child Psychology and Psychiatry

Journal of Intellectual Disability Research

Neuropsychology

Pediatrics

Psychoneuroendocrinology

The Clinical Neuropsychologist

PROFESSIONAL AFFILIATIONS

American Psychological Association


Division 33 (Intellectual and Developmental Disabilities) – American Psychological Association

LICENSURE

Licensed Psychologist, State of California, #16690, 2000 - present

MENTORING AND TEACHING

Dissertation Chair for Alyssa Chavez, Department of Human Development, U.C. Davis

Dissertation Co-Chair for Susannah Cohen, Department of Human Development, U.C. Davis

Mentor to Paula Wadell-Weinstein, M.D., Psychiatry Resident, U.C. Davis School of Medicine

Mentor to Lisa Cordeiro, Department of Human Development, U.C. Davis

Mentor to Laurie Vismara, Ph.D., Autism Research Training Program, MIND Institute

Mentor to Lisa Litt, Ph.D., Autism Research Training Program, MIND Institute

Mentor to Andrea Schneider, Ph.D., Post-Doctoral Fellow, MIND Institute

Co-Facilitator, Doctoring, U.C. Davis School of Medicine

Faculty Member, Autism Research Training Program (PIs David Amaral and Sally Rogers)

Mentor to Stephanie Sansone (Maltas), Department of Human Development, U.C. Davis, National

Science Foundation Graduate Research Fellowship Program, “The Fragile X Premutation and

Differential Susceptibility to Immune Dysfunction: Examination of a Possible Gene-

Environment Interaction with Chronic Stress”

Psy.D. Clinical Internship Supervisor to Amy Gaines

Psy.D. Clinical Internship Supervisor to Corrisa Jacomini

Dissertation Committee Chair, Stephanie Sansone, Human Development, UC Davis

Dissertation Committee Member, Emily Halkett, Psychology, UC Davis

Mentor to Rebecca Shields, Human Development graduate student, UC Davis

Dissertation Committee Member, Abbie Poppa, Neuroscience Graduate Group, UC Davis

Mentor, International Training Program in Neurodevelopmental Disorders, Ying Han (China)

Mentor, International Training Program in Neurodevelopmental Disorders, Ariadna Ramírez Mallafré

(Spain)

Chair, Master’s Thesis Committee, Rebecca Shields, Human Development, UC Davis

GRANTS AND OTHER SUPPORT

Active NICHD – 1R01HD076189

A Cognitive Test Battery for Intellectual Disabilities

Role: PI

Amount: $3,145,326 total for 5 years

Active The John Merck Fund: Developmental Disabilities Translational Research

Grant

Cognitive Training for Fragile X Syndrome

Role: PI



Active NIMH - 2R01MH078041-06

Trajectories and Markers of Neurodegeneration in Fragile X Premutation

Carriers

Role: Co-Equal PI with S. Rivera

Amount: $2,970,846 for 5 years

Active Centers for Disease Control

Fragile X Clinical Research Consortium

Role: UC Davis Site PI

2011-2015 Department of Defense – 10600754

Treatment of Fragile X Syndrome with a Neuroactive Steroid

Role: Co-PI


Active NICHD R01HD036071

Genotype-Phenotype Relationships in Fragile X Families

Role: Co-Investigator

Amount: $2,908,668 for 5 years

2011-2014 HRSA

Controlled Trial of Sertraline in Young Children with Fragile X Syndrome


Amount: $857,090

2013-2014 National Fragile X Foundation

Extending Autism Behavioral Intervention to Young Children with Fragile

X Syndrome

Role: PI

Amount: $50,000 for 1 year

2013 MIND Institute Intellectual Disabilities Research Center (IDDRC) Pilot

Grant

Event-related Oscillatory Brain Activity as Outcome Measure for Targeted

Treatment Trials in Fragile X Syndrome



2007-2013 NIMH - R01MH078041

Limbic System Function in Carriers of the Fragile X Premutation

Role: PI


2011-2013 NIMH - 3R01MH078041-04S1 (Competitive Revision).

Limbic System Function in Carriers of the Fragile X Premutation


Role: PI

Amount: $766,250 total for 2 years

2008-2013 NICHD - R01HD059967-01A2

An Open Resource for Autism iPSCs and Their Derivatives

PI: Charles Schwartz, UCI


Amount: $501,923

2007-2012 NIA - RL11RL1AG032115-01

NeuroTherapeutics Research Consortium

Characterization and Treatment of CNS Abnormalities in Premutation

Carriers

Overall PI: Paul Hagerman; Component PI: Randi Hagerman



2010-2011 National Fragile X Foundation

A Double Blind Randomized Controlled Cross Over Trial of Minocycline

in Children with Fragile X Syndrome

PI: Randi Hagerman

Role: Co-PI

Amount: $75,000

2009-2011 MIND Institute Pilot Research Grant

Candidate Gene Association Analysis of the FMR1 Pathway in Idiopathic

Autism Spectrum Disorders

PI: Simeon Boyd


Amount: $50,000

2009 Seaside Therapeutics

A Double-Blind, Placebo-Controlled, Crossover, Flexible-Dose

Evaluation of the Efficacy, Safety, and Tolerability of STX209 in the

Treatment of Irritability in Subjects with Fragile X Syndrome

PI: Randi Hagerman


Amount: $10,244 per patient

Completed Hoffman-LaRoche

A randomized, double-blind, placebo-controlled, pharmacokinetic, safety

and tolerability, and exploratory efficacy and pharmacodynamic effects

study of RO4917523 in adult patients with fragile X syndrome


Amount: $337,158


2010 FRAXA Research Foundation

Aberrant Behavior Checklist in Fragile X Syndrome

Role: PI

Amount: $10,000

2007-2009 NICHD - R21MH080025

Amygdala Function in Children and Adolescents with Fragile X

Syndrome

PI: Susan Rivera



2009-2010 NCRR/NICHD

A Toolbox of Outcome Measures for Targeted Treatment Trials in

Children – UC Davis Clinical and Translational Science Center

Supplement

PI: Lars Berglund


Amount: $350,380

2005-2010 NIMH - 1K23MH77554: Patient-Oriented Career Development Research

Grant

Genetics and Physiology of Social Anxiety in Fragile X

Role: PI


2008-2009 Neuropharm, Ltd. - NPL-2009-2-FEN-001

An Open Label Exploratory Study to Investigate the Effect of Fenobam

Monohydrate (Fenobam 50 mg – 150 mg single dose) on Prepulse

Inhibition Tests and Continuous Performance Tasks, in Adults with

Fragile X Syndrome

Role: Co-PI

Amount: $53,835 for one year


Sensorimotor Gating in Idiopathic Autism and Autism in Fragile X

Syndrome

Role: PI



Y Chromosome Gene Expression in Autism Spectrum Disorders

PI: Robin Hansen




2006 -2007 Children’s Miracle Network

Autistic Spectrum Disorders and Behavioral Problems in Male Children

with Sex Chromosome Aneuploidy

Role: PI


2005 - 2006 National Fragile X Foundation

Hyperarousal and Aggressive Behavior in Fragile X Syndrome

Role: PI


2002 - 2005 NIH Grant #HD36071: Genotype-Phenotype Relationships in Fragile X

Families

PI: Randi Hagerman, M.D.

Role: Psychologist, 40% support

2004 – 2005 NIH Grant # 1 R01 NS044299-01: Action Tremor and Dementia in Male

Carriers of Fragile X

PI: Jim Grigsby, Ph.D.

Role: Psychologist, 10% support

2003 – 2004 Joe P. Tupin Award – Department of Psychiatry, U.C. Davis: Genetic,

Physiological, and Neuroendocrine Correlates of Anxiety in Fragile X

Syndrome

Amount of award: $35,000

Role: P.I.

PEER REVIEWED JOURNAL ARTICLES

1. Tartaglia NR, Wilson R, Miller JS, Rafalko J, Cordeiro L, Davis S, Hessl D, Ross J. Autism

Spectrum Disorder in Males with Sex Chromosome Aneuploidy (2017). Journal of

Developmental and Behavioral Pediatrics, 38(3):197-207. PMID: 28333849.

2. Wang JY, Hessl D, Hagerman RJ, Simon TJ, Tassone F, Ferrer E, Rivera SM. Abnormal

trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation.

Neurobiology of Aging (55), 11-19. PMID: 28391068.

3. Budimirovic DB, Berry-Kravis E, Erickson CA, Hall SS, Hessl D, Reiss AL, King MK,

Abbeduto L, & Kaufmann WE (In press). Updated report on tools to measure outcomes of

clinical trials in fragile X syndrome. Journal of Neurodevelopmental Disorders.

4. Greiss-Hess L, Fitzpatrick SE, Nguyen DV, Chen Y, Gaul KN, Schneider A, Lemons-Chitwood

K, Eldeeb M, Polussa J, Hessl D, Rivera S, & Hagerman RJ (2016). A randomized, double-

blind, placebo-controlled trial of low-dose sertraline in young children with fragile X

syndrome. Journal of Developmental and Behavioral Pediatrics.

5. Hessl D, Sansone S, Berry-Kravis E, Riley K, Widaman K, Abbeduto L, Schneider A, Coleman

J, Oaklander D, Rhodes K, & Gershon R (2016). The NIH Toolbox Cognitive Battery for

intellectual disabilities: Three preliminary studies and future directions. Journal of

Neurodevelopmental Disorders 8(1), 35.


6. Lozano R, Saito N, Reed D, Eldeeb M, Schneider A, Hessl D, Tassone F, Beckett L, &

Hagerman RJ (2016). Aging in fragile X premutation carriers. The Cerebellum.

doi:10.1007/s12311-016-0805-x.

7. Gossett A, Sansone S, Schneider A, Johnston C, Hagerman RJ, Tassone F, Rivera SM, Seritan

A, & Hessl D (2016). Psychiatric disorders among women with the fragile X premutation

without children affected by fragile X syndrome. American Journal of Medical Genetics Part

B: Neuropsychiatric Genetics.

8. Hessl D & Grigsby (2016). Fragile X-associated tremor/ataxia syndrome: Another phenotype of

the FMR1 gene. Special Issue, Frontiers in Clinical Neuropsychology: Fragile X-Associated

Tremor-Ataxia Syndrome. The Clinical Neuropsychologist 30(6), 810-814.

9. Schneider A, Johnston C, Tassone F, Sansone S, Hagerman RJ, Ferrer E, Rivera SM, & Hessl D

(2016). Broad autism spectrum and obsessive-compulsive symptoms in adults with the fragile

X premutation. Special Issue, Frontiers in Clinical Neuropsychology: Fragile X-Associated

Tremor-Ataxia Syndrome. The Clinical Neuropsychologist 30(6), 929-943.

10. Wang JY, Ngo MM, Hessl D, Hagerman RJ, & Rivera SM (2016). Robust machine learning-

based correction on automatic segmentation of the cerebellum and brainstem. PLoS ONE

11(5): e0156123.

11. Cordeiro L, Abucayan F, Hagerman RJ, Tassone F, & Hessl D (2015). Anxiety disorders in

premutation carriers: Preliminary characterization of probands and non-probands. Intractable

and Rare Diseases Research 4(3), 123-130.

12. Au J, Berkowitz-Sutherland L, Schneider A, Schweitzer JB, Hessl D, & Hagerman RJ (2014). A

feasibility trial of Cogmed working memory training in fragile X syndrome. Journal of

Pediatric Genetics 3(3).

13. Sansone SM, Schneider A, Bickel E, Berry-Kravis E, Prescott C, & Hessl D (2014). Improving

IQ measurement in intellectual disabilities using true deviation from population norms.

Journal of Neurodevelopmental Disorders 6(16), 1-14.

14. McCormick C, Hessl D, Macari SL, Ozonoff S, Green C, Rogers SJ (2014). Electrodermal and

behavioral responses of children with autism spectrum disorders to sensory and repetitive

stimuli. Autism Research 7(4), 468-480.

15. Lozano R, Summers S, Lozano C, Mu Y, Hessl D, Nguyen D, Tassone F, & Hagerman RJ

(2014). Association between macroorchidism and intelligence in FMR1 premutation carriers.

American Journal of Medical Genetics 164A(9), 2206-2211.

16. Brick DJ, Nethercott HE, Montesano S, Banuelos MG, Stover AE, Schutte SS, O’Dowd DK,

Hagerman RJ, Ono M, Hessl D, Tassone F, & Schwartz PH (2014). The autism spectrum

disorders stem cell resource at CHOC Children’s Hospital of Orange County: Implications for

disease modeling and drug discovery. Stem Cells Translational Medicine 3, 1275-1286.

17. Ballinger EC, Cordeiro L, Chavez AD, Hagerman RJ, & Hessl D (2014). Emotion potentiated

startle in fragile X syndrome. Journal of Autism and Developmental Disabilities 44(10),

2536-2546. PMID: 4167929.

18. Loesch DZ, Bui MQ, Hammersley E, Schneider A, Storey E, Stimpson P, Burgess T, Francis D,

Slater H, Tassone F, Hagerman RJ, & Hessl D (2014). Psychological status in female carriers

of premutation FMR1 allele showing a complex relationship with the size of CGG expansion.

Clinical Genetics 87(2), 173-178.

19. Wheeler A, Raspa M, Bann C, Bishop E, Hessl D, Sacco P, & Bailey D (2014). Anxiety,

attention problems, hyperactivity, and the Aberrant Behavior Checklist in fragile X syndrome.

American Journal of Medical Genetics Part A, 164A, 141-155.


20. Cohen S, Masyn K, Mastergeorge A, & Hessl D (2015). Psychophysiological responses to

emotional stimuli in children and adolescents with autism and fragile X syndrome. Journal of

Clinical Child and Adolescent Psychology 44(2), 250-263. PMID: 24156344.

21. Basuta K, Lozano R, Schneider A, Yrigollen CM, Hessl D, Hagerman RJ, & Tassone F (2014).

A family with two females compound heterozygous for the FMR1 premutation. Clinical

Genetics 85(5), 458-463. PMID: 23786467.

22. Schneider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman RJ, & Hessl D

(2013). Electrocortical changes associated with minocycline treatment in fragile X syndrome.

Journal of Psychopharmacology, 27(10), 965-963. PMID: 23981511.

23. Wang JY, Hessl D, Schneider A, Tassone F, Hagerman RJ, & Rivera SM (2013). Fragile X-

associated tremor/ataxia syndrome: Influence of the FMR1 gene on motor fiber tracts in males

with normal and premutation alleles. JAMA Neurology 70(8), 1022-1029. PMID: 23753897.

24. Berry-Kravis E, Hessl D, Abbeduto L, Reiss AL, Beckel-Michener A, & Urv TK (2013).

Outcome measures for clinical trials in fragile X syndrome. Journal of Developmental and

Behavioral Pediatrics, 34(7) 508-522. PMID: 24042082.

25. Russo-Ponsaran N, Yesensky J, Hessl D, & Berry-Kravis E (2014). Feasibility, reproducibility,

and clinical validity of the Pediatric Anxiety Rating Scale – Revised for fragile X syndrome.

American Journal on Intellectual and Developmental Disabilities 119(1), 1-16.

26. Schneider A, Seritan A, Tassone F, Rivera S, Hagerman RJ, & Hessl D (2013). Psychiatric

features in high-functioning adult brothers with fragile X spectrum disorders. The Primary

Care Companion for CNS Disorders, 15(2).

27. Wadell PM, Hagerman RJ, & Hessl D (2013). Fragile X syndrome: Psychiatric manifestations,

assessment, and emerging therapies. Current Psychiatry Reviews, 9: 53-58.

28. Leigh MJS, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P,

Tassone F, Rivera SM, Hessl D, & Hagerman RJ (2013). A randomized double-blind,

placebo-controlled trial of minocycline in children and adolescents with fragile X syndrome.

Journal of Developmental and Behavioral Pediatrics, 34(3), 147-155. PMID: 23572165

29. Kim S, Burris J, Bassal F, Koldewyn K, Chattarji S, Tassone F, Hessl D, & Rivera SM (2012).

Fear-specific amygdala function in children and adolescents on the fragile X spectrum: A

dosage response of the FMR1 gene. Cerebral Cortex 24(3), 600-613. PMID: 23146966

30. Wang JM, Koldewyn K, Hashimoto R, Schneider A, Li L, Tassone F, Cheung C, Hagerman PJ,

Hessl D, & Rivera SM (2012). Male carriers of the FMR1 premutation show altered

hippocampal-prefrontal function during memory encoding. Frontiers in Human Neuroscience,

2(6): 297. PMID: 23115550

31. Wang JY, Hessl D, Iwahashi C, Cheung K, Schneider A, Hagerman RJ, Hagerman PJ, & Rivera

SM (2012). Influence of the fragile X mental retardation (FMR1) gene on the brain and

working memory in men with normal FMR1 alleles. Neuroimage, 65: 288-298. PMID:

23063447

32. Berry-Kravis EM, Hessl D, Rathmell B, Zarevics P, Cherubini M, Walton-Bowen K, Mu Y,

Nguyen DM, Gonzalez-Heydrich J, Wang PP, Carpenter RL, Bear MF, & Hagerman RJ

(2012). Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults

with fragile X syndrome: A randomized, controlled, Phase 2 trial. Science Translational

Medicine, 4(152): 152ra127. PMID: 22993294

33. Hamlin AA, Sukharev D, Campos L, Mu Y, Tassone F, Hessl D, Nguyen DV, Loesch D, &

Hagerman RJ (2012). Hypertension in FMR1 premutation males with and without fragile X-


associated tremor /ataxia syndrome (FXTAS). American Journal of Medical Genetics: Part A.

158A(6), 1304-1309. PMID: 22528549

34. Knox A, Schneider A, Abucayan F, Hervey C, Tran C, Hessl D & Berry-Kravis E (2012).

Feasibility, Reliability, and Clinical Validity of the Tests of Attentional Performance for

Children (KiTAP) in Fragile X Syndrome (FXS). Journal of Neurodevelopmental Disorders

4: 2. PMID: 22958782

35. Chonchaiya W, Au J, Schneider A, Hessl D, Harris SW, Laird M, Nguyen DV, Mu Y, Tassone

F, Hagerman RJ (2011). Increased prevalence of seizures in boys who were probands with

the FMR1 premutation and co-morbid autism spectrum disorder. Human Genetics 131(4),

581-589. PMID: 22001913

36. Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E,

Lachiewicz A, Brown EC, & Hessl D (2011). Psychometric study of the Aberrant Behavior

Checklist in fragile X syndrome and implications for targeted treatment. Journal of Autism

and Developmental Disorders 42(7), 1377-1392. PMID: 21972117

37. Wang JY, Hessl D, Hagerman RJ, Tassone F, & Rivera SM (2012). Age-dependent structural

connectivity effects in fragile X premutation. Archives of Neurology, 69(4), 482-489. PMID:

22491193

38. Selmeczy D, Koldewyn K, Wang JM, Lee A, Harvey D, Hessl D, Tassone F, Adams P,

Hagerman RJ, Hagerman PJ, & Rivera SM (2011). Investigation of amygdala volume in men

with the fragile X premutation. Brain Imaging and Behavior, 5(4), 285-294. PMID: 21786216

39. Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Tassone F, Hagerman PJ, &

Rivera SM (2011). Deficient FMRP underlies amygdala dysfunction in carriers of the fragile

X premutation. Biological Psychiatry, 70(9), 859-865. PMID: 21783174

40. Farzin F, Scaggs F, Hervey C, Berry-Kravis E, & Hessl D (2011). Reliability of eye tracking

and pupillometry measures in individuals with fragile X syndrome. Journal of Autism and

Developmental Disorders, 41(11), 1515-1522. PMID: 21267642

41. Cordeiro, L., Ballinger, E., Hagerman RJ, & Hessl D (2011). Clinical assessment of DSM-IV

anxiety disorders in fragile X syndrome: Prevalence and characterization. Journal of

Neurodevelopmental Disorders 3, 57-67. PMID: 21475730

42. Schneider, A., Ballinger, E., Chavez, A., Tassone F, Hagerman RJ, & Hessl D (2010). Prepulse

inhibition in patients with fragile X-associated tremor ataxia syndrome. Neurobiology of

Aging, 33(6), 1045-1053. PMID: 20961665

43. Chonchaiya, W., Tassone F, Ashwood, P., Hessl D, Schneider, A., Campos, L., Nguyen, D.V.,

Hagerman RJ (2010). Autoimmune disease in mothers with the FMR1 premutation is

associated with seizures in their children with fragile X syndrome. Human Genetics, 30(6),

544-551. PMID: 20809278

44. Yuhas J, Cordeiro L, Tassone F, Ballinger L, Schneider A, Long JM, Ornitz EM, & Hessl D

(2010). Sensorimotor gating in idiopathic autism and autism associated with fragile X

syndrome. Journal of Autism and Developmental Disorders, 41(2), 248-253. PMID:

20521090

45. Utari A, Adams E, Berry-Kravis E, Chavez A, Scaggs F, Ngotran L, Boyd A, Hessl D, Gane L,

Tassone F, Tartaglia N, Leehey M & Hagerman RJ (2010). Aging in fragile X syndrome.

Journal of Neurodevelopmental Disorders, 2(2), 70-76. PMID: 20585378

46. Ashwood P, Nguyen DV, Hessl D, Hagerman RJ, & Tassone F (2010). Plasma cytokine profiles

in Fragile X subjects: Is there a role for cytokines in the pathogenesis? Brain, Behavior, and

Immunity, 24(6), 898-902.


47. Schneider A, Hagerman RJ & Hessl D (2009). Fragile X syndrome: From genes to cognition.

Special issue: Cognitive Profiles in Sex Chromosome Disorders. Developmental

Disabilities Research Reviews, 15(4), 333-342. PMID: 20014363

48. Bourgeois JA, Seritan AL, Casillas EM, Hessl D, Schneider A, Yang Y, Kaur I, Cogswell JB,

Nguyen DV, & Hagerman RJ (2011). Lifetime prevalence of mood and anxiety disorders in

fragile X premutation carriers. Journal of Clinical Psychiatry, 72, 175-182. PMID:

20816038

49. Adams PE, Adams JS, Nguyen DV, Hessl D, Brunberg JA, Tassone F, Zhang W, Koldewyn K,

Rivera SM, Grigsby J, Zhang L, DeCarli C, Hagerman PJ, & Hagerman RJ (2010).

Psychological symptoms correlate with reduced hippocampal volume in fragile X

premutation carriers. American Journal of Medical Genetics: Neuropsychiatric Genetics 3,

775-785.

50. Chonchaiya W, Utari A, Pereira GM, Tassone F, Hessl D, & Hagerman RJ (2009). Broad

clinical involvement in a family affected by the fragile X premutation. Journal of

Developmental and Behavioral Pediatrics, 30, 544-551.

51. Bourgeois J, Coffey S, Rivera SM, Hessl D, Gane LW, Tassone F, Greco C, Finucane B, Nelson

L, Berry-Kravis E, Grigsby J, Hagerman PJ & Hagerman RJ (2009). The family of fragile

X premutation disorders: Expanding the psychiatric perspective. Journal of Clinical

Psychiatry 70(6) 852-862.

52. Farzin F, Rivera SM, & Hessl D (2009). Face processing in individuals with fragile X

syndrome: An eye tracking study. Journal of Autism and Developmental Disorders, 39(6)

946-952. PMID: 2684976

53. Solomon M, Hessl D, Chiu S, Olsen E, & Hendren R (2009). Towards a neurodevelopmental

model of clinical case formulation. Psychiatric Clinics of North America, 32(1) 199-211.

54. Zingerevich C, Greiss-Hess L, Lemons-Chitwood K, Harris S, Hessl D, & Hagerman RJ (2009).

Motor abilities of children with fragile X syndrome. Journal of Intellectual Disabilities

Research, 53(1), 11-18.

55. Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, Hutchinson J, Snape M,

Tranfaglia M, Nguyen DV, & Hagerman RJ (2009). A pilot open-label singe-dose trial of

Fenobam in adults with fragile X syndrome. Journal of Medical Genetics, 46(4) 266-271.

PMID: 19126569

56. Hagerman RJ, Berry-Kravis E, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C,

Kaufmann WE, Hessl D, Visootsak J, Picker J, Gane LW, & Tranfaglia M (2009).

Advances in the treatment of fragile X syndrome. Pediatrics, 123(1), 378-390.

57. Hessl D, Nguyen DV, Green C, Chavez A, Tassone F, Hagerman RJ, Senturk D, Schneider A,

Lightbody A, Reiss AL & Hall S (2009). A solution to limitations of cognitive testing in

children with intellectual disabilities: The case of fragile X syndrome. Journal of

Neurodevelopmental Disorders, 1, 33-45. PMID: 19865612

58. Hessl D, Cordeiro L, Yuhas J, Campbell A, Ornitz E, Berry-Kravis E, Chruscinski E, Hervey C,

Long JM, & Hagerman RJ (2009). Prepulse inhibition in fragile X syndrome: Feasibility,

reliability and implications for treatment. American Journal of Medical Genetics Part B:

Neuropsychiatric Genetics, 150B(4) 545-553.

59. Harris SW, Hessl D, Bacalman S, Goodlin-Jones B, Ferranti J, Herman K, Tassone F, Barbato I,

Hagerman PJ, & Hagerman RJ (2008) Autism profiles of males with fragile X syndrome.

American Journal of Intellectual and Developmental Disabilities 113(6), 427-438.


60. Hagerman RJ, Berry-Kravis E, Hessl D, Coffey S, Schneider A, Nguyen DV, Hervey C,

Hutchinson J, & Snape M (2008). Trial of fenobam, an mGluR5 antagonist, in adults with

Fragile X Syndrome. Journal of Intellectual Disabilities Research, 52(10), 814.

61. Brouwer JR, Severijnen E, de Jong FH, Hessl D, Hagerman RJ, Oostra BA, & Willemsen R

(2008). Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded

CGG-repeat mouse model for fragile X-associated tremor/ataxia syndrome.

Psychoneuroendocrinology, 33, 863-873.

62. García-Nonell C, Ratera ER, Harris S, Hessl D, Ono M, Tartaglia N, Marvin E, Tassone F, &

Hagerman RJ (2008). Secondary medical diagnosis in fragile X syndrome with and without

autism spectrum disorder. American Journal of Medical Genetics, 146A(15), 1911-1916.

63. Koldewyn K, Hessl D, Adams J, Tassone F, Hagerman RJ, Hagerman PJ, & Rivera S (2008).

Reduced hippocampal activation during recall is associated with elevated FMR1 mRNA and

psychiatric symptoms in men with the fragile X premutation. Brain Imaging and Behavior,

2, 105-116.

64. Brega AG, Goodrich G, Bennett RE, Hessl D, Engle K, Leehey MA, Bounds LS, Paulich MJ,

Hagerman RJ, Hagerman PJ, Cogswell JB, Tassone F, Reynolds A, Kooken R, Kenny M, &

Grigsby J (2008). The primary cognitive deficit among males with fragile X-associated

tremor/ataxia syndrome (FXTAS) is a dysexecutive syndrome. Journal of Clinical and

Experimental Neuropsychology, 15, 1-17.

65. Soontarapornchai K, Maselli R, Fenton-Ferrell G, Tassone F Hagerman PJ, Hessl D, &

Hagerman RJ (2008). Abnormal nerve conduction features in fragile X premutation

carriers. Archives of Neurology 65(4), 469-498.

66. Grigsby J, Brega AG, Engle K, Leehey MA, Hagerman RJ, Tassone F, Hessl D, Hagerman PJ,

Cogswell JB, Bennett RE, Cook K, Hall DA, Bounds LS, Paulich MJ & Reynolds A (2008).

Cognitive profile of fragile X premutation carriers with and without fragile X-associated

tremor/ataxia syndrome. Neuropsychology 22(1), 48-60.

67. Hessl D, Tassone F, Cordeiro L, Koldewyn K, McCormick C, Green C, Wegelin J, Yuhas J, &

Hagerman RJ (2008). Aggression and stereotypic behavior in males with fragile X

syndrome: Moderating secondary genes in a “single gene” disorder. Journal of Autism and

Developmental Disorders 38(1), 184-189.

68. Bourgeois JA, Cogswell JB, Hessl D, Zhang L, Ono MY, Tassone F, Farzin F & Hagerman RJ

(2007). Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia

syndrome. General Hospital Psychiatry, 29(4), 349-356.

69. McConkie-Rosell A, Abrams L, Finucane B, Cronister A, Gane LW, Coffey SM, Sherman S,

Nelson LM, Berry-Kravis E, Hessl D, Chiu S, Street N, Vatave A, & Hagerman RJ (2007).

Recommendations from multi-disciplinary focus groups on cascade testing and genetic

counseling for Fragile X associated disorders. Journal of Genetic Counseling 16(5), 593-

606.

70. Solomon M, Hessl D, Chiu S, Hagerman RJ, & Hendren R (2007). A genetic etiology of PDD

guides treatment. American Journal of Psychiatry 164(4): 575-580.

71. Grigsby J, Brega A, Leehey M, Goodrich G, Jacquemont S, Loesch D, Hagerman PJ, Cogswell

J, Epstein J, Wilson R, Jardini T, Gould E, Bennett R, Hessl D, Cohen S, Cook K, &

Hagerman, RJ (2007). Impairment of executive cognitive functioning in males with fragile

X-associated tremor/ataxia syndrome (FXTAS). Movement Disorders, 22(5), 645-650.


72. Chiu S, Wegelin J, Blank J, Jenkins, Day J, Hessl D, Tassone F, & Hagerman RJ (2007). Early

acceleration of head circumference in children with fragile X syndrome and autism. Journal

of Behavioral and Developmental Pediatrics 28, 31-35.

73. Hessl D, Rivera SR, Koldewyn K, Cordeiro L, Adams J, Tassone F, Hagerman PJ, & Hagerman

RJ (2007). Amygdala dysfunction in men with the fragile X premutation. Brain 130(2),

404-416.

74. Leehey M, Berry-Kravis E, Min S, Hall D, Rice C, Zhang L, Grigsby J, Greco C, Lara R,

Cogswell J, Jacquemont S, Hessl D, Tassone F, Hagerman, RJ, & Hagerman, PJ (2007).

Progression of tremor and ataxia in the fragile X-associated tremor/ataxia syndrome.

Movement Disorders 22(2), 203-206.

75. Bourgeois JA, Farzin F, Brunberg JA, Tassone F, Hagerman PJ, Zhang L, Hessl D, & Hagerman

RJ (006). Dementia with mood symptoms in a fragile X premutation carrier with the fragile

X-associated tremor/ataxia syndrome: Clinical intervention with donepezil and venlafaxine.

The Journal of Neuropsychiatry and Clinical Neurosciences 18:2, 171-177

76. Loesch DZ, Quang M, Dissanayake C, Clifford S, Gould E, Bulhak-Paterson D, Tassone F,

Taylor A, Hessl D, Hagerman RJ, & Huggins R (2006). Molecular and cognitive predictors

of the continuum of autistic behaviors in fragile X. Neuroscience and Biobehavioral

Reviews 31, 315-326.

77. Cohen S, Maysn K, Adams J, Hessl D, Rivera S, Tassone F, Brunberg J, DeCarli C, Zhang L,

Cogswell J, Loesch DZ, Leehey M, Grigsby J, Hagerman PJ, & Hagerman RJ (2006).

Molecular and imaging correlates of the Fragile X-associated Tremor Ataxia Syndrome.

Neurology 67(8),1426-1431.

78. Bourgeois JA, Farzin F, Brunberg JA, Tassone F, Hagerman PJ, Zhang L, Hessl D & Hagerman

RJ (2006). Dementia with mood symptoms in a carrier of the fragile X-associated

tremor/ataxia syndrome (FXTAS): Clinical intervention with donepezil and venlafaxine.

The Journal of Neuropsychiatry and Clinical Neurosciences, 18(2), 171-177.

79. Farzin F, Perry H, Hessl D, Loesch DZ, Cohen J, Bacalman S, Gane LW, Tassone F, Hagerman

PJ, & Hagerman RJ (2006). Autism spectrum disorders and attention deficit/hyperactivity

disorder in boys with the fragile X premutation. Journal of Developmental and Behavioral

Pediatrics, 27(2) S137-S144.

80. Hessl D, Glaser B, Dyer-Friedman J, & Reiss AL (2006). Social behavior and cortisol reactivity

in children with fragile X syndrome. Journal of Child Psychology and Psychiatry, 47(6),

602-610.

81. Greco CM, Berman RF, Martin RM, Tassone F, Schwartz PH, Grigsby J, Hessl D, Becker

EJ, Papazian J, Bacalman S, Leehey MA, Hagerman RJ, & Hagerman PJ (2006).

Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain,

129, 243-255.

82. Hessl D, Tassone F, Loesch, DZ, Berry-Kravis E, Leehey M, Gane LW, Barbato I, Rice C,

Gould E, Hall DA, Grigsby J, Wegelin JA, Harris S, Lewin F, Weinberg D, Hagerman PJ &

Hagerman RJ (2005). Abnormal elevation of FMR1 mRNA is associated with

psychological symptoms in individuals with the fragile X premutation. American Journal of

Medical Genetics Part B: Neuropsychiatric Genetics 139B: 115-121.

83. Mothersead PK, Conrad K, Hagerman RJ, Greco CM, Hessl D, & Tassone F (2005). Grand

rounds: An atypical progressive dementia in a male carrier of the fragile X premutation: An

example of Fragile X-Associated Tremor/Ataxia Syndrome. Applied Neuropsychology

12(3), 169-78.


84. Hessl D, Deprey L, Ruiz L, Huff HN, & Hagerman RJ (2004). Vagus nerve stimulation in an

adult male with fragile X syndrome. Mental Health Aspects of Developmental Disabilities,

7(3), 107-113.

85. Hagerman RJ, Leavitt BR, Farzin F, Jacquemont S, Greco CM, Brunberg JA, Tassone F,

Hessl D, Harris SW, Zhang L, Jardini T, Gane LW, Ferranti J, Ruiz L, Leehey MA,

Grigsby J, & Hagerman PJ (2004). Fragile X-Associated Tremor/Ataxia Syndrome

(FXTAS) in females with the FMR1 premutation. American Journal of Human

Genetics, 74(5), 1051-1056.

86. Hessl D, Rivera SM & Reiss AL (2004). The neuroanatomy and neuroendocrinology of fragile

X syndrome. Special issue: Fragile X syndrome: Frontiers of understanding gene-brain-

behavior relationships. Mental Retardation and Developmental Disabilities Research

Reviews, 10, 17-24.

87. Dawson G, Ashman SB, Panagiotides H, Hessl D, Self J, Yamada E & Embry L (2003).

Preschool outcomes of children of depressed mothers: Role of maternal behavior,

contextual risk, and children’s brain activity. Child Development, 74(4), 1158-1175.

88. Johnston C, Hessl D, Eliez S, Dyer-Friedman J, Blasey C, Glaser B, & Reiss AL (2003). Factors

associated with parenting stress in mothers of children with fragile X syndrome. Journal of

Behavioral and Developmental Pediatrics, 24(4), 267-275.

89. Glaser B, Hessl D, Dyer-Friedman J, Johnston C, Wisbeck J, Taylor A. & Reiss AL (2003).

Biological and environmental contributions to adaptive behavior in fragile X syndrome.

American Journal of Medical Genetics, 117A, 21-29.

90. Hessl D, Glaser B, Dyer-Friedman J, Blasey C, Gunnar M, Hastie T & Reiss AL (2002). Cortisol

and behavior in fragile X syndrome. Psychoneuroendocrinology, 27, 855-872.

91. Carrion V, Weems C, Ray R, Glaser B, Hessl D, & Reiss AL (2002). Baseline cortisol in

pediatric PTSD. Biological Psychiatry, 51, 575-582.

92. Dyer-Friedman J, Glaser B, Hessl D, Johnston C, Taylor A, Wisbeck J & Reiss AL (2002).

Genetic and environmental influences on the cognitive outcomes of children with fragile X

syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 41(3),

237-244.

93. Tamm L, Menon V, Johnston C, Hessl D, & Reiss AL (2002). fMRI study of cognitive

interference processing in females with fragile X syndrome. Journal of Cognitive

Neuroscience, 14, 160-171.

94. Hessl D, Dyer-Friedman J, Glaser B, Barajas G, Wisbeck J, Taylor A & Reiss AL (2001). The

influence of environmental and genetic factors on behavior problems and autistic symptoms

in boys and girls with fragile X syndrome. Pediatrics, 108(5), p. e88.

95. Johnston C, Eliez S, Dyer-Friedman J, Hessl D, Glaser B, Blasey C, Taylor A, & Reiss AL

(2001). Neurobehavioral phenotype in carriers of the fragile X premutation. American

Journal of Medical Genetics, 103, 314-319.

96. Dawson G, Ashman SB, Hessl D, Spieker S, Frey K, Panagiotides H, & Embry L (2001).

Autonomic and brain electrical activity in securely- and insecurely-attached infants of

depressed mothers. Infant Behavior and Development, 24, 135-149.

97. Dawson G, Frey K, Panagiotides H, Yamada E, Hessl D, & Osterling J (1999). Infants of

depressed mothers exhibit atypical frontal electrical brain activity during interactions with

mother and with a familiar, nondepressed adult. Child Development, 70(5), 1058-1066.


98. Dawson G, Frey K, Self JF, Panagiotides H, Hessl D, Yamada E, & Rinaldi J (1999). Frontal

brain electrical activation in infants of depressed mothers and nondepressed mothers:

Relations to variations in infant behavior. Development and Psychopathology, 11, 589-605.

99. Dawson G, Frey K, Panagiotides H, Osterling J, & Hessl D (1997). Infants of depressed mothers

exhibit atypical frontal brain activity: A replication and extension of previous findings.

Journal of Child Psychology and Psychiatry, 38(2), 179-186.

100. Dawson G, Hessl D, & Frey K (1994). Social influences on early-developing biological and

behavioral systems related to risk for affective disorder. Special Issue: Neural Plasticity,

Sensitive Periods, and Psychopathology. Development and Psychopathology, 6(4), 759-

779.

BOOK CHAPTERS

1. Halkett ES, Wang JY, Hessl D, & Rivera SM (In press). Neuroimaging findings in FXTAS. In F.

Tassone and D. Hall (Eds.). FXTAS, FXPOI and Other Premutation Disorders. Springer.

2. Leigh MJ, Hagerman RJ, & Hessl D (2012). Fragile X syndrome. In RL Hansen and SJ Rogers

(Eds.) Neurodevelopmental Disorders and Their Treatment. Washington, DC: American

Psychiatric Publishing.

3. Schneider A & Hessl D (2011). Fragile X syndrome. In F. Volkmar (Ed.). Encyclopedia of

Autism Spectrum Disorders. Springer: New York, NY.

4. Chiu S, Hessl D, Day J, & Hagerman RJ (2010). Genetic correlates of psychiatric comorbidity:

Fragile X syndrome. In M. Bax and C. Gillberg (Eds.). Co-Morbidities in Developmental

Disorders. Mac Keith Press: London.

5. Schneider A & Hessl D (2011). Fragile X Syndrome: Life-Course and Strategies for

Intervention. In P. Howlin, T. Charman & M. Ghaziuddin (Eds.). SAGE Handbook of

Developmental Disorders. Sage Publications Ltd: London.

6. Hessl D, Green C, Aguilar D, Cordeiro L, McCormick C & Yuhas J (2009). Developmental

Disability and Fragile X Syndrome: Clinical Overview. In: L.R. Squire (Ed.) Encyclopedia

of Neuroscience, volume 3, pp. 487-494. Oxford: Academic Press.

7. Dawson G & Hessl D (1996). Ethical dilemmas in the assessment of maternal depression. In K.

Hoagwood, P. Jensen, & C. Fisher (Eds.), Ethical Issues in Mental Health Research with

Children and Adolescents. Lawrence Erlbaum Associates: New Jersey.

NON PEER REVIEWED PUBLICATIONS

1. Hessl D, Tassone F, Cordeiro L, Koldewyn K, McCormick C, Green C, Yuhas J, Adams J, &

Hagerman RJ (2006). Aggression and self-injurious behavior in boys and young men with

fragile X syndrome. National Fragile X Foundation Quarterly.

2. Hessl D, Dyer-Friedman J, Glaser B, Erba H, & Reiss AL (2002). Genes, schools and family:

What influences cognitive and behavioral outcome in children with fragile X syndrome?

National Fragile X Foundation Quarterly, Spring Edition.

IN PREPARATION/UNDER REVIEW


PRESENTATIONS, ABSTRACTS, AND POSTERS

1. Hessl D (2017). Invited lecture: Behavioral Outcome Measures for IDD Conditions: What

Works and What Doesn't. Presented at: Looking to the Future: The Next 50 Years of

Intellectual and Developmental Disabilities Research at NICHD, Bethesda, April.

2. Hessl D (2017). Keynote: From Understanding Phenotype to Interventions in Fragile X

Syndrome: Some Paths to Better Outcomes. Fragile X Syndrome Workshop, UK Fragile X

Society, St. Catherine’s College, Oxford, England.

3. Hessl D (2016). Behavioral Assessment in Neurodevelopmental Disorder Clinical Trials: We

Can Do Better! And Here’s How (?) MIND Institute Research Seminar Series.

4. Hessl D & Abbeduto L (2016). Innovative approaches to improving language and cognition in

fragile X syndrome. 15th

International Fragile X Conference, San Antonio, TX.

5. Hagerman RJ, Hessl D, Berry-Kravis E, Jacquemont S, Des Portes V, Wolf , Aposto G,

Koumaras B, Stanfield A, and Von Raison F. Can we reverse intellectual and behavioral

problems in adults with fragile X syndrome? Journal of Intellectual Disability Research 59

(9), 791.

6. Hessl D, Sansone S, Berry-Kravis E, Gershon R, Riley K, Schneider A, Crestodina C, Rhodes K,

& Oaklander D (2016). The NIH Toolbox Cognitive Battery for intellectual disabilities:

preliminary feasibility studies and future directions 49th Gatlinburg Conference on

Research and Theory in Intellectual Disabilities. March, San Diego, CA.

7. Berry-Kravis E, Sansone S, Crestodina C, McLennan Y, Chin J, Joshi R, Schneider A, Leigh MJ,

Hagerman R, Hessl D. Sensitivity of the KiTAP executive function battery and an eye

tracking paradigm to effects of AFQ056 in fragile X syndrome. Ann Neurol 2016;80:S413.

8. Sansone S, Berry-Kravis E, Crestodina C, McLennan Y, Hagerman R & Hessl D (2016).

Sensitivity of an eye tracking paradigm as an outcome measure in a fragile X syndrome

targeted treatment clinical trial. 49th Gatlinburg Conference on Research and Theory in

Intellectual Disabilities. March, San Diego, CA.

9. Wadell, P. M., Abucayan, F., Mulgaonkar, A., & Hessl, D. (2014). Social Gaze in Fragile X

Syndrome and Autism. Poster session presented at: AACAP’s 61st annual meeting;

October 20-25; San Diego, CA.

10. Hessl D (2014). Cognitive outcome measures in fragile X syndrome: Limitations, solutions and

future plans. Gordon Research Conference on Fragile X Syndrome and Autism-Related

Conditions. June 1-6, Mount Snow, Vermont.

11. Wang JY, Hessl D, Schneider A, Tassone F, Hagerman RJ, & Rivera SM (2013). Influence of

the FMR1 gene on motor fiber tracts in males with normal and premutation alleles.

Presented at the 1st International Conference on the FMR1 Premutation: Basic Mechanisms

and Clinical Involvement. June 23-26, Perugia, Italy.

12. Schneider A, Muzar Z, Summers S, Tassone F, Seritan A, Rivera SM, Grigsby J, Hessl D, &

Hagerman RJ (2013). Female characteristics of fragile X-associated tremor/ataxia

syndrome. Presented at the 1st International Conference on the FMR1 Premutation: Basic

Mechanisms and Clinical Involvement. June 23-26, Perugia, Italy.

13. Schneider A, Gaines A, Seritan A, Tassone F, Rivera SM, Hagerman RJ, & Hessl D (2013). A

specific psychiatric profile for female carriers of the FMR1 premutation. Presented at the 1st

International Conference on the FMR1 Premutation: Basic Mechanisms and Clinical

Involvement. June 23-26, Perugia, Italy.


14. Basuta K, Lozano R, Schneider A, Hessl D, Hagerman RJ, & Tassone F (2013). Molecular and

behavior variability in a family with FMR1 related disorders, including two compound

heterozygous females. Presented at the 1st International Conference on the FMR1

Premutation: Basic Mechanisms and Clinical Involvement. June 23-26, Perugia, Italy.

15. Schneider A, Johnston C, Tassone F, Sansone S, Abucayan F, Narcisa V, Hagerman PJ,

Hagerman RJ, Rivera SM, & Hessl D (2012). Social cognition and broad autism phenotype

in men with the fragile X premutation. Journal of Intellectual Disability Research 56(1):

925. Presented at the 15th

Society for the Study of Behavioral Phenotypes International

Research Symposium, Leuven, Belgium.

16. Mulgaonkar A, Sansone S, Schneider A, Chavez, A, Abucayan F, Tassone F, Hagerman RJ, &

Hessl D (2012). Cortisol and stress in fragile X premutation carriers. Poster presented at the

13th

International Fragile X Conference, Miami, FL.

17. Johnston C, Schneider A, Tassone F, Sansone S, Rivera S, Hagerman RJ, & Hessl D (2012).

Memory functioning in male premutation carriers without FXTAS. Presented at the 13th


18. Au J, Schneider A, Berkowitz-Sutherland L, Hessl D, Hagerman RJ, & Schweitzer J (2012).

Evaluation of Cogmed working memory training in fragile X. Presented at the 13th


19. Hessl D, Abucayan F, Mulgaonkar A, Schneider A, Sansone S, Chechi T, Leigh MJ, &

Hagerman RJ (2012). Effect of minocycline treatment on attention and social gaze

processing in children with fragile X syndrome. Presented at the 13th

International Fragile X

Conference, Miami, FL.

20. Schneider A, Adams P, Nanakul R, Chechi T, Hagerman R, Olichney JM, & Hessl D (2012).

Differences in cortical hyperexcitability in fragile X syndrome. Presented at the 13th


21. Schneider A, Adams P, Nanakul R, Chechi T, Leigh MJ, Hagerman RJ, Olichney JM, & Hessl D

(2012). Electrocortical changes during a double blind, placebo controlled trial of

minocycline in children with fragile X syndrome. Presented at the 13th

International Fragile

X Conference, Miami, FL.

22. Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E,

Lachiewicz A, Brown EC, & Hessl D (2012). Psychometric evaluation of the Aberrant

Behavior Checklist factor structure in fragile X syndrome: A multi-site collaborative study.

13th


23. Posussa J, Mulgaonkar A, Schneider A, & Hessl D (2012). Eye tracking as a potential screening

tool for FXTAS in premutation carriers. 13th


24. Hessl D (2012). Proving efficacy in fragile X clinical trials: Measure options, present and future.

Invited presentation at Fragile X and Autism-Related Disorders: From Basic Neuroscience

to Improved Clinical Care. Gordon Research Conference, Stonehill College, Easton, MA.

25. Hessl D (2011). Insights into autism through fragile X research. Invited presentation at the

Autism Working Group of the Stanford Autism Center at Packard Children's Hospital,

Stanford, CA

26. Hessl D, Schneider A, Sumekar T, Cheung K, Hagerman PJ, Roid G (2011). Intelligence

measurement in X linked intellectual disability: Limitations, solutions, and where do we go

from here? 14th

Annual Fragile X and X-Linked Intellectual Disability Conference, Berlin

Germany.


27. Kim S-Y, Burris J, Bassal F, Tassone F, Hessl D, & Rivera SM (2011). Socio-emotional

dysfunction and its relationship with neural correlates of emotional processing in children

and adolescents with fragile X syndrome Society for Neuroscience, Washington DC

28. Russo N, Yesinsky J, Hessl D, & Berry-Kravis E (2011). Feasibility, reproducibility, and

clinical validity of the Pediatric Anxiety Rating Scale (PARS) in fragile X syndrome.

Poster presentation at the Child Neurology Society, Savannah, Georgia

29. Schneider A, Nanakul R, & Hessl D (2010). First Steps into Developing EEG as Medication

Outcome Measure for Targeted Treatments in Fragile X. International Conference on

Genetics and Neurobiology of Mental Retardation, Biennial Conference of the German

Academy of Sciences Leopoldina, National Academy of Sciences, 29th September to 1st

October, 2010, Erlangen, Germany, Molecular Syndromology 2010;1:136-157.

30. Hessl D (2010). Clinical and Physiological Phenotypes in Fragile X-Associated Disorders:

Examples of Outcome Measure Development. John D Wiley Seminar Series . Waisman

Center, University of Wisconsin, Madison, WI

31. Hessl D & Hagerman PJ (2010). FXTAS as a model for understanding neurogenetic disorders.

Translational Grand Rounds, Department of Psychiatry and Behavioral Sciences, UC Davis

32. Rivera SW, Wang J, Koldewyn K, Schneider A, Tassone F, Hagerman RJ, Hagerman PJ,

Iwahashi C, & Hessl D (2010). Gene-brain-behavior relationships in fragile X premutation

carriers: The limbic system. Gatlinburg Conference on Research & Theory in Intellectual &

Developmental Disabilities, Annapolis, MD

33. Hessl D (2010). Cognitive testing in children with intellectual disabilities: A new solution to a

pervasive problem. 25th

Annual Learning and the Brain Conference, San Francisco, CA

34. Wang J, Koldewyn K Hessl D, Selmeczy D, Hagerman RJ, Hagerman PJ, Iwahashi C, Tassone

F, Schneider A, & Rivera S (2009). Fragile X mental retardation-1 gene mRNA as a

predictor for amygdala volume in fragile X premutation men. Poster presented at Society

for Cognitive Neuroscience Annual Meeting, San Francisco, CA

35. Hessl D (2009). What we learn about autism from studying fragile X syndrome. Minds Behind

the MIND lecture series. MIND Institute, UC Davis

36. Hessl D (2008). Outcome measures for clinical trials: What do we have now and what do we

need? FRAXA Investigators Meeting, University of New Hampshire, Durham

37. Hessl D (2008). Thinking outside the box: New neurophysiological and behavioral tools for

clinical research in neurodevelopmental disorders. Presented at the Waisman Center,

University of Wisconsin, Madison

38. Hessl D (2008). Psychophysiology of emotion in fragile X and Down syndromes: Similarities,

contrasts, and implications for treatment. Presented at the Waisman Center, University of

Wisconsin, Madison

39. Farzin F, Rivera SM, Weru J, & Hessl D (2008). Face processing in individuals with fragile X

syndrome: An eye-tracking study. Presented at the 11th International Fragile X Conference,

St Louis, Missouri

40. Adams PE, Adams JS, Nguyen D, Hessl D, Brunburg JA, Tassone F, Zhang L, DeCarli C,

Hagerman PJ, & Hagerman RJ (2008). Psychiatric problems in female fragile X

premutation carriers, with involvement of the hippocampus. Presented at the 11th

International Fragile X Conference, St Louis, Missouri

41. Chavez A, Schneider A, Green C, Nguyen D, Loesch D, Gould E, & Hessl D (2008).

Limitations of the standard IQ score in fragile X syndrome: A proposed solution using an


individual deviation score. Presented at the 11th

International Fragile X Conference, St

Louis, Missouri

42. Hessl D, Schneider A, Cordeiro L, Tassone F, Rivera S, Nguyen D, Gane L, & Hagerman RJ

(2008). Genetic and brain correlates of psychiatric and cognitive functioning in men with

the fragile X premutation. Presented at the 11th

International Fragile X Conference, St

Louis, Missouri

43. Schneider, A, Hessl D, Tassone F, Yuhas, J, Le, L, Chavez, A, Gane, L, & Hagerman RJ (2008)

Two faces of the fragile-X premutation – clinical correlates of CGG repeat size and

methylation Presented at the 11th

International Fragile X Conference, St Louis, Missouri

44. Hessl D (2007) Commonalities in psychophysiological dysfunction in fragile X and autism 10th

International Meeting of the Society for the Study of Behavioural Phenotypes, Sacramento,

CA

45. Rivera, SM, Hessl D, Koldewyn, K, Tassone F, & Hagerman RJ (2007) Brain-based evidence of

limbic system dysfunction in fragile X premutation carriers Presented at the 13th

International Workshop on Fragile X and X-Linked Mental Retardation, Venice, Italy

46. Hessl D, Tassone F, Campbell, A, Cordeiro, L, Yuhas, J, Ornitz, E, & Hagerman RJ (2007)

Prepulse inhibition in fragile X syndrome and FXTAS Presented at the 13th

International

Workshop on Fragile X and X-Linked Mental Retardation, Venice, Italy

47. Hagerman RJ, Soontarapornchai, K, Maselli, R, Fenton-Farell, G, Tassone F, Hessl D, &

Hagerman PJ (2007) Characterization of the neuropathy in the fragile X-associated

tremor/ataxia syndrome (FXTAS) Presented at the 13th

International Workshop on Fragile

X and X-Linked Mental Retardation, Venice, Italy

48. Hessl D, Rivera, S, Koldewyn, K, Cordeiro, L, Adams, J, Tassone F, Hagerman PJ, & Hagerman

RJ (2006) Amygdala dysfunction in men with the fragile X premutation Presented at the

11th

Annual Meeting of the Society for the Study of Behavioural Phenotypes, Royal College

of Surgeons, Dublin, Ireland Journal of Intellectual Disabilities Research, 50, 787

49. Tartaglia, N, Hansen, R, Reynolds, A, Hessl D, Bacalman, S, Goodlin-Jones, B, Deprey, L, &

Hagerman RJ (2006) Attention deficit hyperactivity disorder and autism spectrum disorders

in males with XXY, XYY and XXYY syndromes Presented at the 11th

Annual Meeting of

the Society for the Study of Behavioural Phenotypes, Royal College of Surgeons, Dublin,

Ireland Journal of Intellectual Disabilities Research, 50, 787

50. Hagerman RJ, Adams, J, Adams, P, Nguyen, D, Hessl D, Tassone F, & Hagerman PJ (2006)

FXTAS: A comparison of male vs female involvement Presented at the 11th

Annual

Meeting of the Society for the Study of Behavioural Phenotypes, Royal College of

Surgeons, Dublin, Ireland Journal of Intellectual Disabilities Research, 50, 789

51. Hessl D & Roberts, J (2006) Psychophysiological studies and biophysical outcomes Presented

at the National Institute of Child Health and Human Development Fragile X Meeting,

Atlanta, GA

52. Hessl D, Cordeiro, L, Koldewyn, K, Tassone F, Cohen, S, Green, C, McCormick, C, &

Hagerman RJ (2006) Aggressive behavior in fragile X syndrome: Genetic, physiological,

and environmental factors Presented at the 10th

International Fragile X Conference, Atlanta,

GA

53. Hessl D, Cordeiro, L, Tassone F, & Hagerman RJ (2006) Evidence of reduced

psychophysiological responses to social-emotional stimuli in adult males with the fragile X

premutation Presented at the 10th

International Fragile X Conference, Atlanta, GA


54. Rivera, S, Koldewyn, K, Tassone F, Hagerman RJ, & Hessl D (2006) fMRI evidence of

amygdala dysfunction in men with the fragile X permutation Presented at the 10th

International Fragile X Conference, Atlanta, GA

55. Koldewyn, K, Rivera, S, Hessl D, Tassone F, & Hagerman RJ (2006) Evidence of hippocampal

dysfunction in males with the fragile X premutation Presented at the 10th

International

Fragile X Conference, Atlanta, GA

56. Tartaglia, N, Bacalman, S, Hessl D, Goodlin-Jones, B, Deprey, L, Ono, M, Tsang, S, Davis, S,

Reynolds, A, Wegelin, J, Hansen, R, & Hagerman, R (2006) Autism spectrum disorder in

males with sex chromosome aneuploidy Poster presented at the International Meeting of

Autism Researchers (IMFAR) meeting Montreal, Canada

57. Chiu, S, Wegelin, J, Blank, J, Jenkins, M, Day, J, Hessl D, Tassone F, & Hagerman, R (2006)

Early acceleration of head circumference in children with fragile X syndrome and autism

Poster presented at the International Meeting of Autism Researchers (IMFAR) meeting

Montreal, Canada

58. Hessl D (2006) Psychopathology associated with the fragile X full mutation and premutation

Centers for Disease Control Focused Advisory Group on Psychiatric and Behavioral Issues

in Fragile X Syndrome Sacramento, CA

59. Koldewyn, K, Hessl D, Tassone F, Cordeiro, L, Hagerman RJ & Rivera, S (2006)

Psychophysiological and fMRI evidence of amygdala dysfunction in men with the fragile X

premutation Poster presented at the Annual Cognitive Neuroscience Meeting, San

Francisco, CA

60. Tartaglia, N, Bacalman, S, Goodlin-Jones, B, Deprey, L, Hessl D, Ono, M, Tsang, S, Davis, S,

Reynolds, A, Hansen, R, Hagerman, R (2006) Autism spectrum disorders in males with sex

chromosome aneuploidy Poster presented at the International Meeting for Autism Research,

Montreal, Canada

61. Hessl D (2006) Autism: Best practices in clinical assessment Presented at the 5th

Annual

Developmental Disabilities Conference, University of California, San Francisco, CA

62. Hessl D (2006) Identification and treatment of anxiety and depression in trisomy X and XYY

syndromes Presented at the First National Conference on Trisomy X and XYY

Sacramento, CA

63. Koldewyn, K, Rivera, S, Hessl D, Tassone F, & Hagerman RJ (2005) Evidence of hippocampal

dysfunction in males with the fragile X premutation Poster presented at the 35th

Annual

Society for Neuroscience Meeting, Washington, DC

64. Hessl D, Tassone F, Loesch, DZ, Berry-Kravis E, Leehey, M, Gane LW, Barbato, I, Rice, C,

Gould, E, Hall, DA, Grigsby, J, Wegelin, JA, Harris, S, Lewin, F, Weinberg D, Hagerman

PJ, & Hagerman RJ (2005) Abnormal elevation of FMR1 mRNA is associated with

psychological symptoms in individuals with the fragile X premutation Presented at the 12th

International Workshop on Fragile X and X-Linked Mental Retardation, Williamsburg, VA

65. Hessl D (2005) Hyperarousal, stress, and aggression in fragile X syndrome Presented at

National Fragile X Awareness Day, Sacramento, CA

66. Zhang, L, Coffey, S, Aguis, M, Adams, J, Nowicki, S, Tartaglia, N, Ono, M, Cook, K, Yuhas, J,

Barbato, I, Harris, S, Apperson, M, Gane, L, Tassone F, Hessl D, Cordeiro, L, Brunberg, J,

Hall, D, Leehey, M, Hagerman, P, Hagerman, R (2005) Clinical and MR abnormalities in

females carrying the FMR1 premutation Neurology, 64(6), A92-A93 Presented at the 57th

Annual Meeting of the American Academy of Neurology, Miami Beach, Florida


67. Hessl D (2005) Stress and anxiety in autism and fragile X syndrome Presented at the 1st

International Conference and Clinic on Autism and Fragile X Syndrome, Dubai, United

Arab Emirates

68. Hessl D, Pinter, J, Deprey, L, Chiu, S, Winn, C & Hagerman, R (2005) Autism in a young man

with 8p23 deletion syndrome: Expanding the phenotype? Presented at the 66th

Canadian

Psychological Association Annual Convention, Montreal, Canada

69. Chiu, S, Hessl D, Day, J, Copeland, L, Maddock, R, Hagerman, R & Hendren R (2004)

Pediatric psychosis in fragile X syndrome Presented at the 51st Annual Meeting of the

American Academy of Child and Adolescent Psychiatry, Washington DC

70. Hessl D, Cohen, S, Perry, H, Tassone F, & Hagerman RJ (2004) Potentiated startle and galvanic

skin responses to social and emotional stimuli in children with fragile X: A pilot study

Presented at the Ninth International Fragile X Conference, Washington, DC

71. Hessl D, Tassone F, Perry, H, Cohen, S, Yehuda, R, Makotkine, I, Hagerman PJ, & Hagerman

RJ (2004) Glucocorticoid receptor (GR) mRNA and lymphocyte GR concentration in males

with fragile X syndrome Presented at the Ninth International Fragile X Conference,

Washington, DC

72. Cordeiro, L, Hessl D, Tassone F, Gould, E, Loesch, D, Barbato, I, Perry, H, Gane LW,

Hagerman PJ, & Hagerman RJ (2004) Genotype-phenotype relationships in children with

fragile X: Association between FMR1 protein expression and behavior Presented at the

Ninth International Fragile X Conference, Washington, DC

73. Hessl D, Cohen, S, Gane, L, Jardini, T, Tassone F, Hagerman, P, & Hagerman RJ Structural

neuroimaging and molecular correlates of psychopathology in adult males with the FMR1

premutation (2003) American Journal of Medical Genetics, 73(5), 266 Proceedings of the

53rd

Annual Meeting of the American Society of Human Genetics, Los Angeles

74. Cohen, S, Jaquemont, S, Hessl D, Jardini, T, Harris, S, Tong-Turnbeaugh, R, Jagust, W, Rivera,

S, Gane, L, Tassone F, Hagerman, P, & Hagerman, R (2003) Neuroimaging correlates of

fragile X-associated tremor/ataxia syndrome (FXTAS) Presented at the 11th

International

Workshop on Fragile X Syndrome and X-Linked Mental Retardation, Paphos, Cyprus

75. Hagerman, R, Zhang, L, Brunberg, J, Hessl D, Jacquemont, S, Tassone F, Harris, S, Jardini, T, &

Hagerman PJ (2003) Two female cases of the fragile X premutation tremor/ataxia

syndrome: Cognitive, molecular, and radiological studies Presented at the 11th

International

Workshop on Fragile X Syndrome and X-Linked Mental Retardation, Paphos, Cyprus

76. Hessl D (2003) Psychophysiology of Emotion in Neurodevelopmental Disorders Presented at

Neurodevelopmental Disorders: From Research to Practice, Sacramento, CA

77. Hessl D (2003) Genetic, Environmental, and Physiological Contributions to Behavior in Fragile

X Syndrome Presented at La Trobe University, Bandoora, Australia

78. Hagerman, R, Hessl D, Hess, L, Lemons, K, & Stackhouse, T (2002) Panel on hyperarousal

Presented at Neurodevelopmental Disorders: From Research to Practice, Sacramento, CA

79. Hessl D (2002) Is it all genes? The impact of environmental and neurohormonal variables on

outcome in children with fragile X Presented at the Eighth International Fragile X

Conference, Chicago, IL

80. Dyer-Friedman, J., Hessl D, Glaser, B., Kosaraju, A., & Reiss, A. (2001). The Special

Curriculum Opportunity Rating Scale (SCORS): A measure of educational and therapeutic

effectiveness. Presented at the 14th

Annual Research Conference, A System of Care for

Children’s Mental Health: Expanding the Research Base, Tampa, FL.


81. Hessl D, Reiss, A., & Merin, N. (2000). Magnetic resonance imaging during processing of gaze

in fragile X syndrome. Presented at the Seventh International Fragile X Conference, Los

Angeles, CA, July 2000.

82. Hessl D (2000). Assessment of stress hormone (cortisol) levels in children with fragile X

syndrome. Presented at the Seventh International Fragile X Conference, Los Angeles, CA.

83. Reiss, A., Dyer-Friedman, J., Hessl D, & Glaser, B. (2000). Factors predicting outcome in

fragile X syndrome. Presented at the Seventh International Fragile X Conference, Los

Angeles, CA.

84. Taylor, A., Patterson, K., Dyer, P., Linden, M., Murphy, J., Tassone F, Blasey, C., Hessl D,

Reiss, A., Butler, E., Loesch, D. & Hagerman R. (2000). FMRP expression and clinical

correlates in mosaic males, males with a partially methylated full mutation, and females

with a full mutation. Presented at the Seventh International Fragile X Conference, Los

Angeles, CA.

85. Hessl D & Davidson, J. (1999). A prospective study of stress and health in young children: Is

immune reactivity a source of resilience? Poster presented at the Society for Research in

Child Development Meeting, Albuquerque, NM.

86. Dawson, G., Frey, K., Panagiotides, H., Self, J., Hessl D, & Yamada, E. (1997). Atypical frontal

brain activity in infants of depressed mothers: The role of maternal behavior. Presented at

the Meeting of the Society for Research in Child Development as part of a symposium on

“The Impact of Trauma and Adversity on Behavioral and Physiological Development:

Clarifying the Issues.”

87. Hessl D, Dawson, G., Frey, K., Panagiotides, H., Self, J., Yamada, E., & Osterling, J. (1998) A

longitudinal study of children of depressed mothers: Psychobiological findings related to

stress. In D.M. Hann, L.C. Huffman, K.K. Lederhendler, and D. Meinecke (Eds.)

Advancing research on developmental plasticity: Integrating the behavioral science and the

neuroscience of mental health. National Institute of Mental Health: Bethesda, MD.

88. Dawson, G., Frey, K., Hessl D, Panagiotides, H., & Self, J (1995). Infants of depressed mothers

exhibit atypical frontal brain activity: A replication of previous findings. Presented at the

Meeting of the Society for Research in Child Development, Indianapolis, IN.

89. Hessl D (1998). Fathering young children: Maternal depression, paternal mental health, and

marital adjustment as determinants of involvement and parenting. Dissertation Abstracts

International: Section B: The Sciences & Engineering, 58(8-B), 4450.

Documents

CURRICULUM VITAE David Randal Hessl, Ph.D. · 2017. 5. 26. · CURRICULUM VITAE David Randal Hessl, Ph.D. Department of Psychiatry and Behavioral Sciences and MIND Institute University