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Curriculum Vitae HARVEY SAUL SINGER, M.D.

Date: March 2006

Personal Information:

Harvey Saul Singer, MD Haller Professor of Pediatric Neurology Johns Hopkins University School of Medicine 600 N. Wolfe Street, Jefferson Street Bldg 123 Baltimore, Maryland 21287 Phone: (443) 925-4285 Fax: (410) 614-2297

Education

1958 - 1962 Oberlin College, Oberlin, Ohio, Major Zoology, BA

1962 - 1966 Western Reserve University School of Medicine, Cleveland, Ohio, MD

Post Graduate Education and Training

1966 - 1967 Pediatric Intern University of Illinois, Research and Educational Hospital Chicago, Illinois

1967 - 1970 Pediatric Resident Cleveland Metropolitan General Hospital, Cleveland, Ohio

1969 – 1970 Pediatric Teaching Fellow, Cage Western Reserve University

1972 - 1975 Pediatric Neurology Resident The Johns Hopkins Hospital, Baltimore, Maryland

Certifications American Board Pediatrics (#14822), September 19, 1971. American Board of Psychiatry and Neurology with Special Competence in Child Neurology (#236), April, 1977.

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Medical Licensures Ohio (35-02-9460-S) 1966-present Maryland (D18001), 1972-present Military Services 1970-1972 (Major, U.S. Army) Ireland Army Hospital,

Fort Knox, KY Employment History Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 1975 – 1981 Assistant Professor, Full Time 1981 – 1988 Associate Professor, Full Time 1988 – present Professor, Full Time Jan-Apr 1989 Acting Director, Division of Pediatric Neurology 1991 – present Director, Division of Pediatric Neurology, Johns Hopkins Hospital 1997- present Haller Professor of Pediatric Neurologic Diseases Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore 1975 – 1981 Assistant Professor 1981- 1989 Associate Professor 1989- present Professor Department of Neurology, University of Maryland School of Medicine, Baltimore 2003-present Clinical Professor Consulting Staff appointments: 1979- present Kennedy Krieger Institute 1996- present Mt. Washington Pediatric Hospital Professional Memberships American Academy of Neurology, active 1977-present American Academy of Pediatrics, active 1971- present Child Neurology Society, active 1972- present Maryland Neurological Society, active American Neurological Association, active 19xx- present American Society for Neurochemistry, inactive Society for Neuroscience, active 19xx- present Professors of Child Neurology, 1991- present Alpha Omega Alpha, 1993- present

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Honors and Awards Upjohn Achievement Award for Research, Department of Pediatrics, Cleveland Metropolitan General Hospital 1970 Teacher Investigator Development Award, NIH, 1980-1985 Frank Ford Teaching Award, Department of Neurology, 1985 Hildegaad Doerenkamp and Gerhard Zbinden Foundation for Realistic Animal Protection in Scientific Research, Research award, 1990 Alpha Omega Alpha, March, 1993 Haller Professor of Pediatric Neurologic Disorders, 1997 Visiting Professor, National Children’s Hospital, Oslo, Norway, August, 1994 Visiting Professor, University of New Mexico, Oct., 1996 Visiting Professor, Kapiolani Women and Children’s Medical Center, Honolulu, Hawaii, Jan., 1999 Visiting Professor, Cleveland Metropolitan General Hospital, Cleveland, OH, June 17-18, 1999 Visiting Professor, Oregon Health Sciences University, Portland, OR, May 15-16, 2002 Canadian Royal Society Guest speaker, Canadian Congress of Neurological Specialties, Quebec, Canada, June 19-20, 2003 Institutional Service (1992-present) A. Department of Neurology 1992 – present: Member: Appointments and Promotion Committee 1997 – present: Chairman: Appointments and Promotion Committee Member: Surplus Distribution and Academic Performance Committee Member: Neurology Executive Committee 1997 – 98: Member: Neurology Network Development Committee 1997 – present: Member: Education Committee Member: Jay Slotkin Award Committee B. Department of Pediatrics 1992 – present: Member: Children Center Medical (Operations) Committee Member: Pediatric Specialty Group Committee 1997 – present: Member: Telethon Fund Distribution Committee 2000 – present: Chairman: Telethon Fund Distribution Committee

Member: Pediatric Clinical Practice Committee – Subcommittee on Contracts Member: Medical/Surgical Planning Committee

C. Child Psychiatry Advisory Committee, Pediatric Psychopharmacology Research Unit

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D. University 1992 – present: Member: Ad-hoc Professorial Promotion Committee 1995 – 97: Member: Quality Assurance Committee Member: Medical Student Advisor 1996: Member: Neuroscience Guideline Committee 1997: Member: Johns Hopkins Health Care Professional Advisory Committee Member: Sentinel Event Review Committee Local and National Service

• American Academy of Pediatrics Committee on Drugs (1979 – 1985) • American Academy of Neurology

Resident-In Service Examination Committee Course Director AAN meeting (Pediatric Neurology), 2001 – 2004 Executive Committee, Section of Child Neurology, 2000 - present

• American Board of Neurology and Psychiatry Examiner

• United Council for Neurological Subspecialties Board of Directors 2003 – present Secretary-Treasurer, 2005-

• Child Neurology Society Nomination Committee Archives Committee Practice Committee Education Committee Training Committee – Chairman 2002 – 2005 Chairman, Child Neurology Match Program Committee (2004-present)

• Professors of Child Neurology Membership Committee Secretary Treasurer (1994 – 1997) President (2002 – 2004)

• National Institute of Health Clinical Trials Review Committee

• Tourette Syndrome Association Medical Advisory Board 1998 – 2002 Board Member Greater Washington Chapter, 1994 – present Friends of Tourette Syndrome Research – Board member Planning Committee, TS Medical Symposium Organizing Committee, Tourette Syndrome Foundation of Canada Future Genetic Studies Committee

• National Incontinentia Pigmentia Society Scientific Advisory Board 1995 – present

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• Editorial Board Appointments 1985-89- Assistant editor, Pediatric Neuroscience 1999 - 2004: Neurology 1995 - 2000: Movement Disorders 2004- present: Movement Disorders 1991 - present: Pediatric Neurology 2003 – present: Journal Pediatric Neurology

• Journal Peer Review Activities Reviewer for Pediatrics, Journal of Neurochemistry, Biological Psychiatry, Epilepsy, Child Psychology and Psychiatry, Annals of Neurology, Journal Neurology, Neurosurgery and Psychiatry, Neurology, and others

Teaching Service Director, Pediatric Neurology Attending: Pediatric Neurology ward and consult services; outpatient clinics Pediatric Neurology Grand Rounds – weekly Clinical instruction; medical students and residents Director, yearly Child Neurology Course (Pediatric Trends) Instructor, Neurology course for Year 2 Medical Students Pediatric noon conferences Grant Support

Award: Teacher Investigator Development Award, NIH, 1980-85

(PI)

Grant Award: “The Establishment and validation of an in-vitro system to evaluate neuronal toxicity.” Center for Alternatives to Animal Testing, (PI) 1984-1986.

Grant Award: “Synaptic neurochemical alterations in Tourette syndrome:

An in-vitro and post-mortem analysis, “Tourette Syndrome Association, (PI) 1984-1985.

Grant Award: The Edward C. Stuart Foundation

“Research in Tourette Syndrome.” (PI) 1985-87.

Grant Award: Program Project, “Neurobiology of the mouse model of Down Syndrome,” P.I. project #1, Synaptic neurochemistry of aneuploidy. NIH POI HD 19920, 1985-1989.

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Grant Award: “Role of the supplementary motor area in Tourette syndrome,” (co-investigator) Tourette Syndrome Association, 1986-87.

Grant Award: “Behavioral/Social problems in children with Tourette

syndrome: (co-investigator) Tourette Syndrome Association, 1987-88.

Grant Award: Program Project, “Neurobiology of age-related disorders of

memory and movement.” Investigator (Project 1, age related behavioral abnormalities and their neural substrates; Project 2: The structure and function of BFC neurons and consequences of lesions of this system; Project 3: Neuronal systems implicated in movement abnormalities caused by MPTP) NIH P50 NS20471, 1987-1992.

Grant Award: “Treatment of ADHD in Tourette Syndrome,” Tourette

Syndrome Association, (PI) 1988-1989.

Grant Award: Program Project, “Mapping of the Chromosomes of Man.” Investigator, Project IV, Mapping Selected Neurological Disorders. NIH POI GM 14015 1988-1993.

Grant Award: RO1, “The Treatment of Attention-Deficit Hyperactivity

Disorder in Tourette Syndrome: A double-blind placebo controlled study with clonidine and desipramine.” Prinicipal Investigator. NIH RO1 NS27327, 1989-1991.

Grant Award: Program Project, “Neurodevelopmental Pathways to

Learning Disabilities”. Principal Investigator. Project III, Tourette Syndrome and ADHD: Behavioral and Genetic Analysis. NIH P50 NS35359, 1989-1994 and 1995-2000.

Grant Award: “Nonpharmacologic treatment of tics in Tourette

Syndrome.” Tourette Syndrome Association, (PI) 1992-1993.

Grant Award: “Dopamine uptake site binding: a PET study with [11C]

WIN.” Tourette Syndrome Association, (co-PI) 1992-1993.

Research Training Grant Award: Training Director, Neurological Sciences Academic Development Award (PI)

K12NS01696.1993 – present.

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Grant Award: “Comprehensive neuroanatomical, clinical, psychoeducational and neuropsychological evaluation of girls with TS.” P.I.. Tourette Syndrome Asso, 1994.

Grant Award: “Autoantibodies and Tourette Syndrome.” Tourette

Syndrome Association (PI), 1995-1996.

Grant Award: “The Treatment of ADHD in Children with Tourette’s syndrome (TACT).” (Co-PI), NIH RO1-NS33654, 07/01/96 – 06/30/00.

Grant Award: RO1 “Strep, host factors, autoantibodies and Tourette

syndrome.” (PI), NIH, NS37706. 10/01/99 – 9/30/01.

Grant Award: RO1 “Mechanisms of dopamine and serotonin in Tourette syndrome (co-PI).

Grant Award: “Sib pair study in Tourette syndrome.”

Investigator, NINDS, 5/00 – 4/05.

Grant Award: “A primate model of tics.” (Co-PI). Tourette Syndrome Association. 6/00 – 5/01.

Grant Award: “Dissecting the neurobiology of Tourette syndrome:

Synaptic neurotransmission, immune complexes, and gene expression in postmortem brain tissue.” (PI). Tourette Syndrome Association. 06/01 – 05/02.

Grant Award: “A prospective longitudinal study of PANDAS.

(Investigator), NIH RO1-MH61940. 7/01-6/06

Grant Award: “PANDAS and streptococcal infection: Are they linked?” (Investigator), NIH RO1 – NS32240. 7/01- 6/05.

Grant Award: “A randomized double-blind study of atomoxetine and

placebo in pediatric patients with ADHD and tics.” (Investigator), Eli Lilly.

Grant Award “Immune factors in Tourette syndrome: clarifying the

effect of microinfused sera from children with Tourette syndrome.” (PI), Tourette Syndrome Association, 6/02-5/03,

Grant Award: “Levetiracetam for the treatment of tics.” (PI)

UCB Phamaceuticals, 7/03-6/04,

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Grant Award: “Levetiracetam for the treatment of tics.” (PI) Tourette Syndrome Association, 7/03-6/04

Grant Award: “Pharmacogenetics of TS”, (PI)

NIH R21NS044939-01A1. 9/03 – 8/05

Grant Award: “Maternal Autoantibodies in Autism” National Alliance for Autism Research (PI) 7/05 -6/06

Publications ORIGINAL ARTICLES 1) HS, Nankervis Ga, Schafer IA: Leukocyte beta-galactosidase activity in the diagnosis of generalized GM-1 gangliosidosis. Pediatrics 49:352-361, 1972. 2) Singer HS, Schafer IA: Clinical and enzymatic variations in GM-1 generalized

gangliosidosis. Am J. Hum. Genet. 24:454-462, 1972. 3) Singer HS, Freeman JM: Seizures in adolescents. Med. Clinics of North America

59:1461-1472, 1975. 4) Singer H, Skoff R, Price D: Development of intersegmental connection in the chick

spinal cord prior to closure of reflex arc. Anatomical Record 184:529, 1976. 5) Leahy WR, Singer HS: Progressive focal deficit with porencephaly. Arch. Neurol.

34:154-156, 1997. 6) Singer HS, Valle D, Rogers J, Thomas G: The stiff skin syndrome: New genetic and

biochemical investigations. Birth Defects – Original Article Series 13:245-255, 1977. 7) Johnson GG, Pepple JM, Singer HS, Littlefield JW: HGPRT in the Gilles de la Tourette 8) Zee DS, Yee RW, Singer HS: Congential ocular motor apraxia. Brain 100:581-599, 1977. 9) Singer HS, Freeman JM: Head trauma for the pediatrician. Pediatrics 62:819-825, 1978. 10) Singer HS: Computerized tomography in the diagnosis of intracranial bleed. J. Peds. 92:341-342, 1978. 11) Butler IJ, Seifert WE, Koslow SH, Caprioli RM, Singer HS: Neurotransmitters in neurological disorders in childhood. Proceedings 4th International Catecholamine Symposium, Pacific Grove, California 1978.

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12) Singer HS, Pepple JM, Ramage AL, Butler IJ: Gilles de la Tourette syndrome. Further studies and thoughts. Ann. Neurol. 4:21-25, 1978. 13) Singer HS, Skoff RP, Price DL: The development of inter-segmental connections in embryonic spinal cord: An anatomic substrate for early embryonic motility. Brain Research 141:197-209, 1978. 14) Niedermeyer E, Singer H, Folstein S, et al: Hypersomnia with simultaneous waking and sleep patterns in the electroencephalogram. J. Neurol. 221:1-13, 1979. 15) Butler IJ, Koslow SH, Seifert WE, Caprioli RM, Singer HS: Biogenic amine metabolism in Tourette syndrome. Ann Neurol. 6:37-39, 1979. 16) Singer HS: What’s new and important in pediatric neurology? Medical Tribune 21:12- 13, 1980. 17) Singer HS, Coyle JT, Vermom N, Kallman CH, Price DL: The development of catecholaminergic innervation in chick spinal cord. Brain Research 191:417-428, 1980. 18) Singer HS: Computerized tomography in pediatric neurology disorders. Pediatrics in Review 2:139-144, 1980. 19) Singer HS, Rabins P, Tune LE, Coyle JT: Serum haloperidol levels in Gilles de la Tourette syndrome. Biol Psychiat. 16:79-84, 1981. 20) Singer HS, Coyle JT, Frangia J, Price DL: Effects of spinal transection on presynaptic markers for glutamateric neurons in the rat. Neurochem Res. 6:485-496, 1981. 21) Singer HS: A commentary: Psychotropic drugs in pregnant and lactating women. American Academy of Pediatrics Committee on Drugs. Pediatrics, 69:241-244, 1982. 22) Johnston MV, Singer HS: Brain neurotransmitters and neuromodulators in pediatrics. Pediatrics. 70:57-68, 1982. 23) Singer HS, Coyle JT, Weaver DL, Kawamura N, Baker HJ: Neurotransmitter chemistry in feline GM2 gangliosidosis: A model for human ganglioside storage disease. Ann. Neurol. 12:37-41, 1982 24) Hreidarsson S, Magram G, Singer HS: Symptomatic atlanto-axial dislocation in Down’s Syndrome. Pediatrics, 66:568-571, 1982. 25) Shinnar S, Singer HS, Valle D: Acute hydrocephalus in the Hurler syndrome. Am. J. Dis. Child. 136:556-557, 1982. 26) Singer HS: Valproic acid: benefits and risks. American Academy of Pediatrics Committee on Drugs. Pediatrics, 70:316-319, 1982.

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27) Singer HS, Butler IJ, Tune LE, Seifert WE, Coyle JT: Dopaminergic dysfunction in Tourette syndrome. Ann. Neurol. 12:361-366, 1982. 28) Kandt RS, Emerson RG, Singer HS, Valler DL, Moser HW: Cataplexy in variant forms of Neimann-Pick Disease. Ann. Neurol. 12:284-288, 1982. 29) Singer HS: Tics and Tourette Syndrome. Johns Hopkins Med. J. 151:30-35, 1982. 30) Singer HS: Tics and Noises: The Tourette Syndrome. Neurology and Neurosurgery Updates. 4:1-8, 1983. 31) Singer HS, Weaver D, Tiemeyer M, Coyle JT: Synaptic chemistry associated with abberant neuronal development in the Reeler mouse. J. Neurochemistry. 41:874-881, 1983. 32) Krumholz A, Singer HS, Niedermeyer E, Burnite R, Harris K: Electrophysiologic studies in Tourette syndrome. Ann. Neurol. 14:638-641, 1983. 33) Coyle JT, Singer HS, Beaulieu M, Johnston MV: Development of central neurotransmitter-specific neuronal systems: Implications for pediatric neuro- psychiatric disorders. Acta Scand. Neurol. 69:1-11, 1984. 34) Singer HS, Oshida L, Coyle JT: CSF cholinesterase in Tourette syndrome. Arch. Neurol., 41:756-757, 1984. 35) Kandt RS, Shinnar S, D’Souza BJ, Singer HS, Wharam MD, Prabodh KG: Cerebrospinal metatases in malignant childhood astrocytomas. J. Neuro. Oncology, 2:123-128, 1984. 36) American Academy of Pediatrics Committee on Drugs: Ethanol in Liquid preparations intended for children. Pediatrics, 73:405-407, 1984. 37) Rosenberg LA, Harris JC, Singer HS: The relationship of the Child Behavior Checklist

to an independent measure of psychopatholoy. Psychological Reports 54:427-430, 1984. 38) Shinnar S, Singer HS: Cobalamin C mutation (methylmalonic aciduria and homocystinuria) in adolescence: A treatable cause of dementia and myelopathy. New Engl. J. Med., 311:451-454, 1984. 39) Singer HS, Tiemeyer M, Hedreen JC, Gearhard J, Coyle JT: Morphologic and neurochemical studies of embryonic brain development in murine trisomy-16. Devel. Brain Research, 15:155-166, 1984. 40) Tiemeyer MJ, Singer HS, Troncoso JC, Cork LC, Coyle JT, Price DL: Synaptic neurochemical alterations associated with neuronal degeneration in an inherited cerebellar ataxia of Gordon Setters. J. Neuropath. Exp. Neurol., 46:580-591, 1984.

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41) Cairns LJ, Green WR, Singer HS: GM2 gangliosidosis, Type 2: Ocular clinicopathologic correlation. Graefe’s Arch. Clin. Exp. Ophthalmol 222:51-62, 1984. 42) Palmer M, Green R, Valle DL, Singer HS, Morton SJ, Maumenee IH, Moserr HW: Niemann-Pick Disease-Type C: Ocular histopathologic and electron microscopic studies, Arch. Ophthal. 103:817-822, 1985. 43) Yeager AM, Singer HS, Buck JR, Matalon R, Brennan S, O’Donnell O’Toole S, Moser HW: A therapeutic trial of amniotic epithelial cell implantation in patients with lysosomal storage diseases. Am J Med Genet, 22:347-355, 1985. 44) Singer HS: Behavioral and cognitive effects of anticonvulsants. American Academy of Pediatrics Committee on Drugs. Pediatrics, 76:644-647, 1985. 45) Maria BL, Cafferty LL, Singer HS, Epstein JI, Carson BS: Diffuse leptomeningeal seeding from a malignant spinal cord astrocytoma in a child with neurofibromatosis. J. Neuro Oncology, 4:159-163, 1986. 46) Singer HS, Rorke LB: Clinical Pathological correlation: Metachromatic leukodystropy. Pediat. Neurosci., 12:31-37, 1986. 47) Gearhart JD, Singer HS, Moran TH, Tiemeyer M, Oster-Granite ML, Coyle JT: Mouse chimeras composed of trisomy 16 and normal (2nd) cells: Preliminary studies. Brain Res Bulletin 16:815-824, 1986. 48) Singer HS, Gammon K, Quasky S: Haloperidol, fluphenazine and clonidine in Tourette syndrome: Controversies in treatment. Pediat. Neurosci., 12:71-74, 1986., 49) Lasker AG, Zee DS, Hain TC, Folstein SJ, Singer HS: Saccades in Huntington’s Disease: Initiation defects and distractibility. Neurology, 37:364-370, 1987. 50) Singer HS, Tiemeyer M, Slesinger PA, Sinnott M: Inactivation of GM1 -ganglioside β-galactosidase by a specific inhibitor: A model for ganglioside storage disease. Ann. Neurol., 21:497-503, 1987.

51) Slesinger P, Singer HS: Effects of anticonvulsants on cell growth, enzyme and receptor binding activity in neuroblastoma x glioma hybrid cell culture. Epilepsia 28:214-221, 1987. 52) Whitehouse PJ, Vale WW, Zweig RM, Singer HS, Mayeux R, Kuhar MJ, Price DP, Desouza EB: Reductions in corticotropin-releasing factor-like immunoreactivity in cerebral cortex in Alzheimer’s disease, Parkinson’s disease and progressive supranuclear palsy. Neurology, 37:905-909, 1987. 53) D’Amato RJ, Zweig RM, Whitehouse PJ, Wenk GL, Singer HS, Price DL, Snyder

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SH: Aminergic systems in Alzheimer’s Disease and Parkinson’s Disease: Abnormalities of serotonin neurons. Ann. Neurol., 22:229-236, 1987. 54) Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT: An autoradiographic study of the development of [3H]-hemicholinium-3 binding sites: a marker for the sodium dependent high affinity choline uptake system, in the human and baboon basal ganglia. Devel. Brain Research, 34:291-297, 1987. 55) Kennedy CR, Singer HS: Eosinophillia of the cerebrospinal fluid: Late reaction to a silastic shunt. Devel. Med. Child Neurol, 30:386-390, 1988. 56) Lasker AG, Zee DS, Hain TC, Folstein SE, Singer HS: Saccades in Huntington’s disease: slowing and dysmetria. Neurology, 38:427-431, 1988. 57) Whitehouse PJ, Martino AM, Marcus K, Zweig RM, Singer HS, Price DL, Kellar KJ: Reductions in acetylcholine and nicotine binding in several degenerative diseases. Arch. Neurol., 45:722-724, 1988. 58) Farmer M., Singer HS, Mellits ED, Hall D and Charney E: Neurobehavioral sequelae of minor head injuries in children. Pediatric Neurosci, 13:304-308, 1987/88. 59) Slesinger PA, Lowenstein PR, Singer HS, Walker LC, Casanova MF, Price DL and

Coyle JT: The development of β1 and β2 adrenergic receptors in baboon brain: An autoradiographic study using [125I]Iodocyanopindolol. J Comp Neurology 273:318-329, 1988.

60) Searles C, Singer HS: The identification and characterization of a GABAergic system in a cholinergic neuroblastoma x glioma hybrid clone 61) Searles CD, Slesinger PA, Singer HS: Effect of anticonvulsants on cholinergic and GABAergic properties in the neuronal cell clone NG108-15. Neurochem. Res., 13: 1007-1013, 1988. 62) Singer HS, Valle D., Hayasaka K, Tada K: Nonketotic hyperglycinemia: Studies in an atypical variant. Neurology, 39:286-288, 1989. 63) Singer HS, Cork LC: Canine GM2 gangliosidosis: Morphological and biochemical analysis. Vet. Pathol., 26:114-120, 1989. 64) Singer HS, Rosenberg LA: The development of behavioral and emotional problems in Tourette syndrome. Pediatric. Neurol., 5:41-44, 1989. 65) Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova ML, Raskin LS, Price DL, Coyle JT: Compartment specific changes in the density of choline and dopamine uptake sites and muscarinic and dopamine receptors during development of the baboon striatum. J. Comp. Neurol, 288:428-446, 1989.

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66) Singer HS, Hahn I-H, Krowiak BS, Nelson E, Moran T: Tourette syndrome: A neurochemical analysis of postmortem cortical brain tissue. Ann Neurol., 27:443-446, 1990. 67) Shuper A, Bryan RN, Singer HS: Destructive encephalopathy in incontinenti pigmenti; a primary disorder? Pediatric Neurol., 6:137-140, 1990. 68) Singer HS, Searles CD, Hahn I-H, Marsh J, Troncoso J: The effect of aluminum on markers for synaptic neurotransmission, cyclic AMP, and neurofilaments in a neuroblastoma x glioma hydridoma (NG108-15). Brain Res., 528:73-79, 1990. 69) Singer HS, Walkup J: Tourette syndrome and other tic disorders: Diagnosis, pathophysiology, and treatment. Medicine, 70:15-32, 1991. 70) Northam RS, Singer HS: Acquired Tourette-like syndrome in child following encephalitis. Neurology, 41:592-593, 1991. 71) Goldstein EM, Singer HS: Moyamoya-like disease in Down syndrome. Ped Neurosci, 16:14-16, 1990-91. 72) Singer HS, Hahn I-H, Moran T: Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette syndrome. Ann. Neurol., 30:558-562, 1991. 73) Walkup JT, Rosenberg LA, Brown J, Singer HS: The validity of instruments measuring tic severity in Tourette syndrome. J. Am. Acad. Child Adolesc. Psychiatry 30:472-477, 1992. 74) Singer HS, Rowe S: Chronic recurrent headaches in children. Pediatr. Ann., 21:369- 373, 1992. 75) Allen R, Singer HS, Brown JE, Salam M: Sleep disorders in Tourette syndrome: A primary or unrelated problem? Pediatric Neurol., 8:275-280, 1992. 76) Repka MX, Singer HS: Gilles de la Tourette syndrome and the afferent visual system. Neuro-ophthalmology, 12:367-374, 1992. 77) Singer HS, Reiss AL, Brown J, Aylward EH, Shih B, Chess E, Harris EL, Reader MJ, Chase GA, Bryan RN, Denckla MB. Volumetric MRI changes in basal ganglia of children with Tourette’s syndrome. Neurology, 43:950-959, 1993. 78) Singer HS: Tic disorders. Pediatric Ann, 22:22-29, 1993. 79) The Tourette Syndrome Classification Group: Definition and classification of tic disorders. Arch Neurol, 50:1013-1016, 1993.

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80) Singer HS: Migraine in children. Pediatrics in Review, 15:94-101, 1994. 81) Rosenberg LA, Brown J, Singer HS. Self-reporting of behavior problems in patients with tic disorders. Psychological Reports, 74:653-654, 1994. 82) Singer HS, Chiu AY, Meiri KF, Morell P, Nelson PG, Tennekoon G: Recent advances in developmental neurobiology. Current Opinion in Neurology, 7:153-159, 1994. 83) Fisher PG, Wechsler DS, Singer HS: Anti-Hu antibody in neuroblastma-associated paraneoplastic syndrome. Pediatr Neurol, 10:309-312, 1994. 84) Singer HS. Neurobiological issues in Tourette syndrome. Brain & Development, 16:353-364, 1994. 85) Singer HS, Schuerholz L, Denckla MB. Learning difficulties in children with Tourette syndrome. J Child Neurol, 10:S58-S61, 1995. 86) Singer HS, Brown J, Quaskey S, Rosenberg L, Mellits ED, Denckla MB. Alternative treatments for attention-deficit hyperactivity disorder in Tourette’s syndrome: A double-blind placebo-controlled study with clonidine and desipramine. Pediatrics, 95: 74-81, 1995. 87) Singer HS, Dickson J, Martinie D, Levine M. Second messenger systems in Tourette’s syndrome. J Neurological Sciences, 128:78-83, 1995. 88) Singer HS. Demystifying Tourette syndrome. Contemporary Pediatrics, 12:43-55, 1995. 89) Rosenberg LA, Brown J, Singer HS: Behavioral problems and severity of tics. J Clin Psychiatry, 51:760-767, 1995. 90) Harris EL, Schuerholz LJ, Singer HS, Reader MJ, Brown JE, Cox C, Mohr J, Chase GA, Denckla MB. Executive function in children with Tourette syndrome and/or attention deficit hyperactivity disorder. J International Neuropsychology Society, 1:511-516, 1995. 91) Schuerholz LJ, Baumgardner TL, Singer HS, Reiss AL, Denckla MB. Neuropsychological status of children with Tourette’s syndrome with and without attention deficit hyperactivity disorder. Neurology, 46:958-965, 1996. 92) Aylward EH, Reiss AL, Reader MJ, Singer HS, Brown JE, Denckla MB. Basal Ganglia, 11:112-115, 1996. 93) Baumgardner TL, Singer HS, Denckla MB, Rubin MA, Abrams MT, Colli MJ, Reiss AL. Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder. Neurology, 47:477-482, 1996.

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94) Walkup JT, LaBuda MA, Singer HS, Brown J, Riddle MA, Hurko O. Family study and segregational analysis of Tourette’s syndrome: Evidence for a mixed model solution. Am J Hum Genetics, 59:684-693, 1996. 95) Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Brain development, gender and IQ in children: A volumetric imaging study. Brain 119:1763-1774, 1996. 96) Mazzocco MM, Denckla MB, Singer HS, Scanlon DM, Vellutino FR, Reiss AL. Neurogenetic and neurodevelopmental pathways to learning disabilities. Learning Disabilities 8:31-42, 1997. 97) Singer HS, Dela Cruz PS, Abrams MT, Bean CS, Reiss AL. A Tourette-like syndrome following cardiopulmonary bypass and profound hypothermia: MRI volumetric measurements. Mov Disord, 12:588-592, 1997. 98) Singer HS, Krumholz A, Giuliano J, Kiessling LS. Antiphospholipid antibodies: An epiphenomenon in Tourette syndrome. Mov Disord 12:738-742, 1997. 99) Wong DF, Singer HS, Brandt J, Shaya E, Chan B, Chen C, Brown J, Kimball AW, Gjedde A, Dannals RF, Hayden PD, Ravert HT, Wagner HN. D2-like dopamine receptor density in Tourette syndrome measured by PET imaging. J Nuclear Med, 38:1243-147, 1997. 100) Schuerholz LJ, Cutting L, Mazzocco MM, Singer HS, Denckla MB. Neuromotor functioning in children with Tourette syndrome with and without attention deficit hyperactivity disorder. J Child Neurology 12:438-442, 1997. 101) Bergin A, Waranch HR, Brown J, Carson K, Singer HS. Relaxation therapy in Tourette syndrome: a pilot study. Pediatr Neurol, 18:136-142, 1998. 102) Schuerholz LJ, Singer HS, Denckla MB. Gender study of neuropsychological and neuromotor functioning in children with Tourette syndrome with and without attention deficit hyperactivity disorder. J Child Neurology, 13:277-282, 1998. 103) Singer HS, Giuliano JD, Hansen BH, Hallett JJ, Laurino JP, Benson M, Kiessling LS.

Antibodies against human putamen in children with Tourette syndrome. Neurology, 50: 1618-1624, 1998. 104) Bakdash T, Goetz CG, Singer HS, Cardoso F. A child with recurrent episodes of involuntary movements. Mov Disord 14:146,154, 1999. 105) Tourette Syndrome Study Group. Short-term versus longer term pimozide therapy in Tourette’s syndrome: A preliminary study. Ann Neurol, 52:875-877, 1999. 106) Singer HS, Giuliano JD, Hansen BH, Hallett JJ, Laurino JP, Benson M, Kiessling LS.

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Antibodies against a neuron-like (HTB-10 neuroblastoma) cell in children with Tourette syndrome. Biol Psychiatry, 46:775-780, 1999. 107) Mostofsky SH, Wendlandr J, Cutting L, Denckla M, Singer HS. Corpus callosum measurement in girls with Tourette syndrome. Neurology, 53:1345-1347, 1999. 108) Singer HS, Hansen B, Martinie D, Karp CL. Mitogenesis in glioblastoma multiforme cell lines: a role for NGF and it’s TrkA receptors. J. Neuro-Oncology, 45:1-8, 1999. 109) International Consortuim for TS Genetics. A Complete genome screen in sib-pairs affected with the Gilles de la Tourette syndrome. Am J Hum Genet, 65:1428-1436, 1999. 110) Singer HS, Commentary: PANDAS and immunomodulatory therapy. Lancet 354:1137-1138, 1999. 111) Sallee FR, Kurlan R, Goetz CG, Singer H, Scahill L, Law CG, Dittman VM, Chappell PB. Ziprasidone treatment of children and adolescents with Tourette’s syndrome: A pilot study. Am Acad Child Adolesc Psychiatry, 39:292-299, 2000. 112) Zimmerman AM, Abrams MT, Giuliano JD, Reiss AL, Denckla MD, Singer HS: Subcortical volumes in preadolescent females with Tourette syndrome: Support for a gender effect. Neurology, 54:2224-2229, 2000. 113) Kates WR, Singer HS. Sex chromosomes, testosterone and the brain. [Editorial] Neurology. 54:2201-2202, 2000. 114) Singer HS, Giuliano JD, Zimmerman A, Walkup JT. Infection as an environmental stimuli in children with tic disorders. Pediatr Neurol, 22:380-383, 2000. 115) Casey MB, Cohen M, Schuerholz LJ, Singer HS, Denckla M. Language-based cognitive functioning in parents of offspring with ADHD comorbid for Tourette syndrome or learning disabilities. Developmental Neuropsychology, 17:85-110, 2000. 116) Singer HS. 10 most commonly asked questions about Tourette syndrome. The Neurologist, 6:302-306, 2000. 117) Singer HS. Current issues in Tourette syndrome. Mov Disord, 15:1051-1063, 2000. 118) Mahone EM, Koth CW, Cutting L, Singer HS, Denckla MB. Executive function in fluency and recall measures among children with Tourette syndrome or ADHD. J Int Neuropsychol Soc, 7:102-111, 2001. 119) Singer HS, Wendlandt J, Krieger M, Giuliano J. Effect of baclofen treatment in treatment in Tourette syndrome: A double-blind, placebo-controlled, crossover trial. Neurology, 56:599-604, 2001.

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120) Singer HS, Naidu S. Rett syndrome: “we’ll keep the genes on for you.” Neurology, 56:582-585, 2001. 121) Singer HS. The treatment of tics. Current Neurology and Neuroscience Reports, 1:195-202, 2001. 122) Kossoff E, Singer HS. Tourette syndrome: Clinical characteristics and current management strategies. Pediatric Drugs, 3:355-363, 2001 123) Wendlandt JT, Grus FH, Augustin AJ, Hansen BH, Singer HS: Striatal antibodies in children with Tourette’s syndrome: Multivariate discriminant analysis of IgG repertoires. J Neuroimmunol, 119:106-113, 2001. 124) Mostofsky SH, Singer HS, Lasker AG, Denckla MB, Zee DS: Oculomotor abnormalities in Tourette syndrome with and without ADHD. J Am Acad Child Adolesc Psychiatry, 40:1464-1472, 2001. 125) Loiselle CR, Singer HS. Sydenham’s chorea: an autoimmune disorder? J Am Acad Child Adolesc Psychiatry, 40:1234-1236, 2001. 126) Fredericksen KA, Cutting LE, Kates WR, Mostofsky SH, Singer HS, Cooper KL, Lanham DC, Denckla MB, Kaufman WE. Disproportionate increases of white matter in right frontal lobe in Tourette syndrome. Neurology, 58:85-89, 2002. 127) The Tourette Syndrome Study Group. Treatment of ADHD in children with tics: A randomized controlled trial. Neurology 58:527-536, 2002. 128) Tourette Syndrome Association International Consortium for Genetics: Obsessive- compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette’s syndrome. Submitted. 129) Kates WR, Frederiksen M, Mostofsky S, Folley B, Cooper K, Mazur-Hopkins P, Kofman O, Singer H, Denckla MB, Pearlson GD, Kaufman WE: MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder. Psychiatric Research: Neuroimaging, 116:63-81, 2002 130) Mahone EM, Cirino PT, Cutting LE, Cerrone PM, Hagelthorn KM, Hiemenz JR, Singer HS. Denckla MB. Validity of the behavior rating inventory of executive function in children with ADHD and/or Tourette syndrome. Arch Clin Neuropsychology, 17:643-662, 2002. 131) Mahone EM, Hagelthorn KM, Cutting L, Scheurholz LJ, Pelletier SF, Rawlins C, Singer HS, Denckla MB. The effects of IQ on executive function measures in children with ADHD. Child Neuropsychology, 8:52-65, 2002.

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132) Singer HS, Szymanski S, Giuliano JD, Yokoi F, Dogan AS, Brasic JR, Zhou Y, Grace AA, Wong D. Elevated intrasynaptic dopamine release in Tourette syndrome measured by PET. Am J Psychiary, 159:1329-1336, 2002. 133) The Tourette Syndrome Association International Consortium for Genetics. Genome wide scan of hoarding in sibling pairs both diagnosed with Gilles de la Tourette syndrome. Am J Hum Genetics, in press. 134) Singer HS. Modern concept of tic disorders. Kinesis, 7:20-26, 2002. 135) Cummings DD, Singer HS, Krieger M, Miller TL, Mahone EM. Neuropsychiatric effects of guanfacine in children with mild Tourette syndrome: a pilot study. Clin Neuropharmacology, 25:325-332, 2002. 136) Loiselle Cr, Wendlandt JR, Rohde CA, Singer HS. Anti-streptococcal, neuronal, and Nuclear antibodies in Tourette syndrome: influences of co-morbid ADHD and OCD. Pediatr Neurol, 28:119-125, 2003. 137) Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW, Task Force on Childhood Motor Disorders. Classification and definition of disorders causing hypertonia in childhood. Pediatrics, 111:e89-e97, 2003 138) Singer HS, Loiselle C. PANDAS: a commentary. J Psychosomatic Res., 55:31-39, 2003. 139) Singer HS, Loiselle CR, Lee O, Garvey M, Grus FH. Anti-basal ganglia antibody abnormalities in Sydenham’s chorea. J Neuroimmunology, 136:154-161, 2003. 140) Jordan LC, Singer HS. Sydenham’s chorea in children. Current Treatment Options in Neurology, 5:283-290, 2003. 141) Singer HS, Minzer K. Neurobiology of Tourette syndrome: concepts of

neuroanatomical localization and neurochemical abnormalities. Brain and Development, 25, Suppl. 1, S70-S84, 2003.

142) Loiselle CR, Lee O, Moran TH, Singer HS. Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes. Mov Disord, 19:390-396, 2004. 143) Singer HS, Loiselle CR, Lee O, Minzer K, Swedo S, Grus FH. Anti-basal ganglia antibodies in PANDAS. Mov Disord, 19:406-415, 2004. 144) Minzer K, Lee O, Hong JJ, Singer HS. Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum. J Neurol Sci, 219:55-61, 2004

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145) Singer HS, Hong J, Rippel C, Pardo-Villamizer C. The need for caution in considering

the diagnostic utility of antibasal ganglia antibodies in movement disorders. Arch Gen Pediatr, 89: 595-597, 2004.

146) Matsuo M, Tsuchiya K, Hamasaki Y, Singer HS. Transient restless legs syndrome: possible association with streptococcal and/or mycoplasma infection. Pediatr Neurol, 31: 119-121, 2004 147) Hong JJ, Loiselle CR, Comi AM, Becker KG, Singer HS. Microarray analysis of

postmortem putamen from Tourette syndrome patients. J Neurol Sci, 225: 57-64, 2004. 148) Mahone ME, Bridges D, Prahme C, Singer HS. Repetitive arm and hand movements

(complex motor stereotypies) in children. J Pediatrics, 145:391-395, 2004. 149) Singer HS. PANDAS – is it a specific clinical disorder? Revista Brasileria de

Psiquiatria, 26:220-221, 2004. 150) Kates WR, Lanham DC, Singer HS. Frontal white matter reductions in healthy boys

with complex motor stereotypies, Pediatr Neurol, 32: 109-112, 2005. 151) Singer HS. Tourette syndrome: from behaviour to biology. Lancet Neurol, 4: 149-159,

2005 152) Rippel CA, Hong JJ, Yoon DY, Williams P, Singer HS. Methodologic factors affect the

measurement of anti-basal ganglia antibodies. Ann Clin Lab Science, 35: 121-130, 2005. 153) Singer HS, Mink JW, Loiselle CR, Burke KA, Ruchkina I, Morshed S, Parveen S,

Leckman JF, Hallett JJ, Lombroso PJ. Microinfusion of antineuronal antibodies into rodent striatum: failure to differentiate between elevated and low titers, J Neuroimmunol, 163: 8-14, 2005.

154) Abelson JF, Kwan KY, O’Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rašin M-R, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, Singer HS, Gilbert DL, Farhl A, Louvi A, Lifton RP, Šestan N, State MW. Mutations in SLITRK1 are associated with Tourette syndrome. Science 310:317-320, 2005. 1) Singer HS, Hong JJ, Yoon DY, Williams PN: Serum autoantibodies do not differentiate

PANDAS and Tourette syndrome from controls, Neurology 65: 1701-1707, 2005 2) Singer HS. Discussing outcome in Tourette syndrome. Arch Pediatr Adolesc Med 160:

103-105, 2006.

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3) Miller JM, Singer HS, Waranch HR. Simplified habit reversal and positive reinforcement therapy for stereotypic movements in non-autistic children. J Child Neurology, in press.

4) Yoon DY, Rippel CA, Kobets AJ, Morris CM, Lee JE, Williams PN, Bridges DD,

Vandenbergh DJ, Shugart YY, Singer HS. Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3), submitted

155) Rippel CA, Kobets AJ, Yao Y, Yoon DY, Singer HS. Norepinephrine transporter

promoter and coding region polymorphisms in Tourette syndrome with and without ADHD, submitted

160) Singer HS, Morris CM, Williams PN, Yoon DY, Hong JJ, Zimmerman AW. Antibrain antibodies in children with autism and their unaffected siblings, submitted

161) Wong DF, Brašic JR, Singer H, Schretlen D, Kuwabara H, Zhou Y, Nandi A, Maris M, Alexander M, Ye W, Rousset O, Kumar A, Grace AA. Mechanisms of dopamine and serotonin in Tourette syndrome: Clues from an in vivo neurochemistry study with PET, submitted

162) Yoon DY, Gause CD, Leckman JL, Singer HS. Prefrontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis, submitted

163) Harris K, Singer HS. Tic disorders: Neural circuits, neurochemistry, and neuroimmunology, J Child Neurology, in press.

164) Olson LL, Singer HS, Goodman WK, Maria BL. Tourette syndrome: diagnosis, strategies, therapies, pathogenesis and future research directions, J Child Neurology, in press

CHAPTERS (1) Singer HS, Schaefer IA: Clinical and enzymatic variations in GM generalized

gangliosidosis. Biochemical Basis of Inherited Human Disease, MSS Information Corp., New York, 1973.

(2) Butler IJ, Seifert WE, Koslow SH, Caprioli RM, Singer HS: Neurotransmitters in

neurologic disorders of childhood. Catecholamines: Basic and Clinical Frontiers, Used in E, Kopin I and Barchas J (editors), Pergamon Press, New York, 1979.

(3) Singer HS: Isovaleric acidemia. Handbook of Clinical Neurology, Vol. 42, Neurogenic

Directory Part I, Myrianthopoulos NC (ed), North Holland Publishing Company, Amsterdam, pp. 579-580, 1981.

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(4) Singer HS: Histidinemia. Handbook of Clinical Neurology, Vol. 42, Neurogenic Directory Part I, Myrianthopoulos NC(ed), North Holland Publishing Company, Amsterdam, pp. 563-564, 1981.

(5) Singer HS: Dibasic aminoacidurias. Handbook of Clinical Neurology, Vol. 42,

Neurogenic Directory Part I, Myrianthopoulos NC (ed), North Holland Publishing Company,Amsterdam, pp. 563-564, 1981.

(6) Singer HS: Anticonvulsants and pregnancy. Seizure Disorder Update, Vol. 2. Parke

Davis, New Jersey, 1981. (7) Singer HS, Tune LE, Butler IJ, Zaczek R, Coyle JT: Clinical symptomatology, CSF

neurotransmitter metabolites and serum haloperidol levels in Tourette syndrome. Gilles de la Tourette Syndrome, Chase TN and Friedhoff AJ (eds) Raven Press, New York, 177-183, 1982.

(8) Baker HJ, Walkley SU, Rattazza MC, Singer HS, Watson HL, Wood PA: Feline

gangliosidosis as models of human lysosomal storage diseases. Animal Models of Inherited Metabolis Diseases. Desnick RJ, Patterson DF, Scarpelli DG (eds). Alan R. Liss, Inc., New York, pp. 203-211, 1982.

(9) Shinnar S, Singer HS, Valle D: Acute hydrocephalus in Hurler's Syndrome.

Year Book of Hydrocephalus. 1983. (10) Singer HS: Treatment of Tics. Current Therapy in Neurology, Johnson R (ed) B.C. Decker, Inc. Philadelphia, pp. 267-293, 1982. (11) Singer HS, Tiemeyer M: The establishment of an in-vitro system to evaluate neuronal

toxicity. Alternative Methods in Toxicology, Vol. 3, Mary Ann Liebert, New York, pp. 267-293, 1985.

(12) Singer HS: Los tics y el syndrome de Tourette. Rassegna 6:31-37, 1985 (13) Singer HS, McKhann GM: Storage disorders. Diseases of the Nervous System,Clinical

Neurobiology, Asbury AK, McKhann GM, McDonald WI (eds). Ardmore Medical Books, Philadelphia, pp. 716-735, 1986.

(14) Coyle JT, Gearhart JD, Oster-Granite ML, Singer HS, Moran TH: Brain

neurotransmitters: Implications for Downs syndrome from studies of mouse TS-16. The Neurobiology of Downs Syndrome. Epstein CJ (ed) Raven Press, New York, pp. 153-169, 1986.

(15) Dean JM, Singer HS: Status epilepticus. Textbook of Pediatric Intensive Care. Rogers

MC (ed). Williams and Wilkins, Baltimore, pp. 615-628, 1987.

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(16) Zee DS, Lasker AJ, Hain TC, Folstein SJ, Singer HS: Eye movement disorder in basal ganglia disease. Movement Diseases II, Neurology of the Extrapyramidal System. Findley LJ, Gresty M (eds). MacMillian.

(17) Singer HS: Animal models of ganglioside storage diseases. Animal Models of

Dementia: A Synaptic Neurochemical Perspective. Coyle JT (ed). AR Liss, New York, pp 199-222, 1987.

(18) Singer HS, Searles C, Slesinger P: Effect of anticonvulsants on the neuroblastoma x

glioma hybrid cell line NG108-15. Model Systems In Neurotoxicology. Alternative Approaches to Animal Testing, Shahar A, Goldberg AM (eds), Alan R. Liss, New York, pp 339-347, 1987.

(19) Oster-Granite ML, Gearhart JD, Roger RH, Singer HS, Moran TH, Coyle JT: Down

Syndrome and the Trisomy 16 Mouse. Animal Models of Dementia: A Synaptic Neurochemical Perspective. Coyle JT (ed). AR Liss, New York, pp 279-307, 1987.

(20) Oster-Granite ML, Coyle JT, Reeves RH, Singer HS, Moran TH, Gearhart JD: Down's

syndrome and the trisomy 16 mouse: relevant to Alzheimer's disease. Banbury Report 27: Molecular Neuropathology of Aging. Cold Spring Harbor Laboratory, Mass., pp 387-398, 1987.

(21) Singer HS, Trifiletti R, Gammon K: The role of "other" neuroleptic drugs in the

treatment of Tourette syndrome, Tourette's Syndrome and Tic Disorders Cohen DJ, Bruun RD, Leckman JF (eds). John Wiley, New York, pp. 303-316, 1988.

(20) Waranch RH, Singer HS: Treatment of recurrent headaches in children.

Current Therapy of Pain. Foley KM, Payne R (eds). B.C. Decker, Philadelphia, pp. 192-204, 1989.

(23) Singer HS: Tourette syndrome and attention-deficit hyperactivity disorder. Attention-

Deficit Disorder, Hyperactivity, and Learning Disabilities: Current Theory and Practical Approaches. Denckla MB (ed). Ciba-Geigy Publication, Summit, New Jersey, pp. 11-20, 1989

(24) Singer HS: Treatment of attention-deficit hyperactivity disorders. Current Therapy in

Neurologic Disease-3, Johnson R (ed), B.C. Decker, Inc. Philadelphia, pp. 283-288, 1989.

(25) Singer HS, Wong DF, Brown JE, Brandt J, Krafft L, Shaya E, Dannals RF, Wagner HN: Positron emission tomography evaluation of dopamine D2 receptors in adults with Tourette syndrome. Advances in Neurology, Vol. 58. Chase TN, Friedhoff AJ, Cohen DJ (eds). Raven Press, New York, pp. 233-239, 1992.

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(26) Singer HS: Neurochemical analysis of post-mortem cortical and striatal brain tissue in patients with Tourette syndrome. Advances in Neurology, Vol. 58. Chase TN, Friedhoff AJ, Cohen DJ (eds). Raven Press, New York, pp. 135-144, 1992.

(27) Kurlan R, Singer HS: Involuntary movements in a 10-year-old child. Clinical Seminars in

Mov Disord, NCM Publishers, New York, Vol 1, pp. 3-8, Dec 1992. (28) Singer HS: The pathobiology of Tourette syndrome. In: Kurlan R (ed). Handbook of

Tourette Syndrome and Related Tic and Behavioral Disorders, Marcel Dekker, pp. 267-288, 1993.

(29) Singer HS: GM1 Gangliosidosis. In: Neurobase, Gilman S, Goldstein GW, Waxman SG

(eds.), v. x, Arbor Publishing Corp, Rochester. (30) Singer HS: Update on Tourette's syndrome. In: Progress in Pediatric Neurology,

Millichap JG (ed), PNB Publishers, Chicago, 1994. (31) Fisher PG, Bergin AM, Singer HS. Seizure Disorders. In: Child and Adolescent

Psychiatric Clinics of North America, W.B. Saunders, Philadelphia, Vol 4, pp 461-481, 1995.

(32) Bergin AM, Singer HS. Treatment of Tourette Syndrome. In: Conn's Current Therapy,

Rakel RE (ed), W.B. Saunders, Philadelphia, pp 855-858, 1996. (33) Singer HS: Tourette Syndrome. In: Developmental Disabilities in Infancy and Childhood,

2nd edition, Capute AJ, Accardo PJ (eds.). Paul Brooks Publishing Co, Baltimore, Vol 2, pp.497-510, 1996.

(34) Singer HS, Carson B. Treatment of hydrocephalus. In: Current Therapy in Neurologic Disease-, Johnson R, Griffin J (eds.), B.C. Decker, Inc. Philadelphia, pp 100-103, 1996. (35) Mostofsky S, Singer HS: Neuropsychological problems associated with Tourette

syndrome. In: Neurobase, Gilman S, Goldstein GW, Waxman SG (eds.), v. x. Arbor Publishing Corp, Rochester.

(36) Singer HS. Neurobiology of Tourette's syndrome. In: Neurology Clinics of North

America, Vol 15, Number 2. W.B.Saunders: Philadelphia, pp 357-379, 1997. (37) Wong DF, Ricaurte G, Grunder G, Rothman R, Naidu S, Singer H, Harris J, Yokoi F,

Villemagne V, Szymanski S, Gjedde A, Kuhar M. Dopamine transporter changes in neuropsychiatric disorders. In: Catecholamines: bridging basic science with clinical medicine.Goldstein DS, Eisenhofer G, McCarty R (eds.), Academic Press, San Diego, pp 219-223, 1998.

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(38) Singer HS. Movement disorders in childhood. In: Parkinson's Disease and Movement Disorders 3rd Edition. J Jankovic, E Tolosa (eds.) Williams and Wilkins, Baltimore, pp 729-753, 1998

(39) Giuliano J, Singer HS. Commentary on Sallee FR, Nesbitt L, Jackson C, et al. Relative

efficacy of haloperidol and pimozide in children and adolescents with Tourette’s disorder. Am J Psychiatry1997; 154: 1057-1062. Evidence-Based Mental Health, 1:45, 1998.

(40) Singer HS. Paroxysmal movement disorders in children. In: Current Management in

Child Neurology, Maria B (ed), Decker Periodicals, Hamilton, Ont, 1999, pp260-263.. (41) Singer HS.Tourette syndrome and its associated neurobehavioral problems. In: Pediatric

Neurology: Principles and Practice, 2nd edition, Swaiman K, Shields D (eds.), C.V. Mosby, Baltimore,1999,598-605.

(42) Singer HS. Paroxysmal movement disorders. Continuum, Lippincott Williams and

Wilkins, Philadelphia, 2000;6:178-194. (43) Singer HS, Wendlandt JT: Neurochemistry and synaptic neurotransmission in Tourette

syndrome. Adv Neurol 2001; 85:163-178. (44) Singer HS. Treatment of Tourette syndrome. In: Current Therapy in Neurologic Disease-

Vol 6, Johnson RT, Griffin JW, McArthur JC (eds), Mosby, Inc. Philadelphia, 2001, (45) Gilbert D, Singer HS. Commentary on article entitled: Risperidone and pimozide. Am J

Psychiatry. Evidence-Based Mental Health, 2001; 3:75. (46) Stephenson D, Singer HS. Tourette syndrome. In: Diseases of the Nervous System,Clinical Neuroscience and Therapeutic Principles, 3rd edition, Asbury AK, McKhann GM, McDonald WI, Goadsby, McArthur JC (eds). Cambridge University Press, New York, 2002, 551-567. (47) Singer HS. Movement disorders in children. In: Parkinson's Disease and Movement

Disorders 4th Edition. J Jankovic, E Tolosa (eds.) Williams and Wilkins, Baltimore, 2002, 451-472.

(48) Singer HS, Minzer K. Neurobiological issues in Tourette syndrome. In:

Handbook of Tourette Syndrome and Related Tic and Behavioral Disorders, Second Edition, Kurlan R (ed). Marcel Dekker, New York, 2005, 273-318.

(1) Singer HS, Smith-Hicks C, Lieberman D. Tourette’s syndrome. In: Animal Models of Movement Disorders, LeDoux M (eds) Elsevier, 2005, 431-440.

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(50) Singer HS. Treatment of Tourette syndrome. In: Treatment in Pediatric Neurology, Singer HS, Kossoff EH, Hartman A, Crawford TO (eds) Taylor & Francis Group, 2005, 125-132.

(51) Jordan LC, Singer HS. Treatment of chorea. In: Treatment in Pediatric Neurology, Singer HS, Kossoff EH, Hartman A, Crawford TO (eds) Taylor & Francis Group, 2005, 133-144. (52) Singer HS. Tourette syndrome and its associated neurobehavioral problems. In, Pediatric

Neurology: Principles and Practice, 3rd edition, Swaiman K, Shields D, Ferrario D (eds), C.V. Mosby, Baltimore, in press

(53) Cerullo J, Reimschisel T, Singer HS. Genetic and neurobiological bases for Tourette syndrome. In: Managing Tourette Syndrome: A Multidisciplinary Approach. Woods D, Piacentini J, Walkup J. (eds), Guilford Press, in press. (54) Hartman AL, Singer HS. Tourette syndrome and its associated neurobehavioral

problems. In: Developmental Disabilities in Infancy and Childhood, 3rd edition, Hoon A, Accardo PJ (eds.). Paul Brooks Publishing Co, Baltimore, in press

(1) Mink JW, Dure LS, Singer HS. Abnormal Movements: Tourette syndrome and

poststreptococcal disorders. In: Pediatric Update, Vol 25, February 2005.

(2) Burnette WB, Singer HS. Movement disorders. In, Children with Handicaps, Batshaw ML (eds), in press

(57) Singer HS, Williams PN. Autoimmunity and pediatric movement disorders. In, Advances in Neurology, Vol 99, J Walkup, J Mink, P Hollenbeck (eds), Lippincott Williams and Wilkins, Philadelphia, 2006, 166-178. (1) Singer HS. Movement disorders in children. In: Parkinson's Disease and Movement

Disorders 5th Edition. J Jankovic, E Tolosa (eds.) Williams and Wilkins, Baltimore, in press.

(2) Singer HS and Harris K. Circuits to synapses: The pathophysiology of Tourette syndrome. In, Neurobiology of Diseases, Elsevier, in press.

BOOKS (1) Singer HS, Kossoff EH, Hartman A, Crawford TO (eds) “Treatment in Pediatric Neurology”, Taylor & Francis Group, 2005. . (1) Singer HS, Mink J, Jankovic J. “Movement Disorders in Pediatrics”. Butterworth Heinemann. In preparation.

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ABSTRACTS (1) Singer HS, Butler IJ, Seifert WE, Caprioli RM, Koslow SH: Tourette syndrome - a

neurotransmitter disorder? (Abstract) Ann. Neurol. 4:189, 1978. (2) Singer HS, Coyle JT, Price DL: Monoaminergic innervation in developing spinal cord

(Abstract) Neurology 28:375, 1978. (3) Singer HS, Butler IJ, Rothenberg SP, Valle D, Freeman JM: Interrelationships among

serum folate, CSF folate, neurotransmitters and neuropsychiatric symptoms. (Abstract) Ann. Neurol. 8:214, 1980.

(4) Singer HS, Coyle JT, Hess K, Baker HJ: Neurotransmitter chemistry in feline GM-1

gangliosidosis, A model for human ganglioside storage disease. (Abstract) Ann Neurol. 8:214, 1980.

(5) Singer HS, Tune LE, Butler IJ, Zaczek R, Coyle JT: Clinical symptomatology, CSF

neurotransmitter metabolites and serum haloperidol levels in Tourette syndrome. (Abstract) Ann. Neurol. 10:303, 1981.

(6) Krumholz A, Singer H, Burnite R, Niedermeyer E: Electrophysiologic studies in the

Tourette syndrome.(Abstract) Tourette Syndrome International Symposium. May 1981. (7) Singer HS, Weaver D, Coyle JT: Synaptic chemistry of hereditary cerebellar dysgenesis

in the reeler mouse. (Abstract) Ann. Neurol 10:307, 1981. (8) Baker HJ, Walkley SU, Rattazzi MC, Singer HS, Watson HL, Wood PA: Feline

gangliosidosis as models of human lysosomal storage diseases. (Abstract) AFIP Workshop, October, 1981.

(9) Troncosa J, Singer HS, Cork L, Price DL, Coyle JT: Canine inherited ataxia (CIA):

Ultrastructural and neuro-chemical observations (Abstract). Neurology 32:A83, 1982. (10) Kawamura N, Singer HS, Moser HW, Coyle JT, Baker HJ: GM1 accumulation in

synaptosomal membranes of feline GM1 Transactions AM. Soc. Neurochem, 13:95, 1982. (11) Singer HS, Weaver D, Coyle JT: Synaptic chemistry in a mouse model with aberrant

neuronal development. Transactions. Am. Soc. Neurochem, 13:207, 1982. (12) Singer HS, Kawamura N, Coyle JT, Baker HJ: Synaptic membrane dysfunction in feline

GM1 gangliosidosis (Abstract). Society Pediatric Research. 1982.

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(13) Hreidarsson S, Valle D, Holtzman N, Coyle J, Singer H, Kapatos G, Kaufman S: A peripheral defect in biopter in synthesis: A new mutant? (Abstract). Society Pediatric Research. 1982.

(14) Singer HS, Troncosa J, Tiemeyer M, Cork L, Coyle JT, Price DL: Canine inherited

ataxia (Abstract). Ann. Neurol. 12:218-219,1982. (15) Singer H, Tiemeyer M, Hedreen J, Gearhart J, Coyle J: Neuropathological and

neurochemical studies in murinetrisomy-16. (Abstract) Neurology 33 [Suppl 2]:132, 1983.

(16) Singer HS, Oshida L, Coyle JT: Cerebrospinal fluid cholinesterase activity in Tourette's

Syndrome. (Abstract) Ann. Neurol. 14:362, 1983. (17) Shinnar S, Singer HS: Cobalamin C mutation in an adolescent girl: A new treatable

cause of dementia. (Abstract) Ann. Neurol. 14:360-361, 1983. (18) Gearhart J, Singer H, Tiemeyer M, Coyle J: Neurochemical studies of the trisomy 16

mouse. (Abstract) American Society for Human Genetics, Norfolk, Virginia, 1984. (19) Singer HS, Tiemeyer M, Sinnott M: Chronic reduction of B-galactosidase activity: An

in-vitro model for GM1 gangliosidosis. (Abstract) Neurology 34 [Suppl 1]:197, 1984. (20) Wong DF, Wagner HN, Jr., Dannals RF, Frost JJ, Ravert HT, Links JM, Folstein M, Uhl G, Tune L, Folstein S, Singer H, Preziosi T, Kuhar MJ: D2 dopamine receptors in normal and pathological states imaged by positron tomography. Soc. Neurosci. Abstr. Vol. 10, part 2, 1984. (21) Singer HS, Wong DF, Tiemeyer M, Whitehouse P, Wagner HN: pathophysiology of Tourette syndrome: a PET and postmortem analysis. (Abstract), Ann. Neurol. 18: 416, 1984. (22) Singer HS, Cork L, Slesinger P, Thomas G: AB variant of GM2 gangliosidosis:

morphologic and neurochemical observations in a German Shorthair Pointer. (Abstract), Ann.Neurol. 18:396-397, 1985.

(23) Singer HS, Slesinger P: Effects of anticonvulsants on a neuroblastoma x glioma hybrid

cell line: cell growth and synaptic neurochemistry. (Abstract), Epilepsia 26:519, 1985. (24) Singer HS, Slesinger P: Effect of therapeutic levels of"unbound" anticonvulsants on a

neuronal cell clone: cell growth and synaptic neurochemistry (Abstract). Neurology 36 (Suppl) 326-327.

(25) Singer HS, Gammon K, Quaskey S: Haloperidol, fluphenazine and clonidine in the

treatment of Tourette syndrome. (Abstract), Ann. Neurol. 20:438, 1986.

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(26) Resar LM, Kaplan RA, Green WR, Singer HS: The role of the conjunctival biopsy in the diagnosis of neurodegenerative disease, (Abstract), Ann. Neurol. 20:408, 1986.

(27) Singer HS, Slesinger PA, Lowenstein PR, Walker LC, Casanova MF, Price D, Coyle J:

The maturation of pre-and postsynaptic neurotransmitter markers in baboon striatum, (Abstract), Ann. Neurol. 20:430, 1986.

(28) Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Price DL:

Development of cholinergic and dopaminergic pre- and postsynaptic markers in the baboon and human striatum, Society for Neuroscience Abstracts. 12:1230,1986.

(29) Slesinger PA, Lowenstein PR, Walker LC, Casanova MF, Price DL, Coyle JT, Singer

HS: Ontogeny of B1 and B2 adrenergic receptors in the baboon: an in-vitro autoradiographic study, Society for Neuroscience Abstracts. 12:1230, 1986.

(30) Traboulsi EI, Green WR, Singer HS, Resar LM: Electron microscopy of conjunctival

biopsies in metabolic and neurodegenerative diseases - revisiting 181 biopsies, Association for Research in Vision and Ophthalmology, 1987.

(31) Singer HS, Rosenberg L: The development of behavioral/social problems in Tourette

syndrome. Child Neurology Society. (Abstract) 1987. (32) Singer HS, Searles C, Slesinger P, Coyle JT: Principles of synaptic neurochemical

development as demonstrated by an autoradiographic analysis of pre-and postsynaptic cholinergic binding. Ann. Neurol., 22:433, 1987.

(33) Singer HS, Searles C: The effect of anticonvulsants of GABAergic activity in a neuronal

cell clone. Ann. Neurol., 22:433, 1987. (34) Singer HS, Searles C, Slesinger PA, Lowenstein PR and Coyle JT: The ontogeny of

cholinergic muscarinic receptors in mouse [3H]pirenzepine. Society for Neuroscience Abstracts 13:1987.

(35) Singer HS: Differential effect of anticonvulsants on cholinergic and GABAergic activity

in a neuronal cell clone. (Abstract) The American Epilepsy Society, 1987. (36) Farmer MY, Singer HS, Mellits ED, Charney E: Neurobehavioral sequelae of minor

head injuries in children. Ann. Neurol. 24:338-339, 1988. (37) Singer HS, Searles C, Oster-Granite ML, Coyle JT: Mechanisms for retardation in

chromosomal disorders, Ann. Neurol. 24:338-339, 1988. (38) Singer HS, Searles CD, Troncoso J: Aluminum neurotoxicity in cultured cells. Society

for Neuroscience Abstracts, 14:924, 1988.

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(39) Searles CD, Singer HS, Coyle JT: The ontogeny of α and ß adrenergic receptors in mouse forebrain: a quantitative autoradiographic study. Society for Neuroscience Abstracts, 14:924, 1988.

(40) Wong DF, Singer HS, Pearlson G, Tune L, Ross C, Villemagne V, Dannals RF, Links

JM, Wilson A, Ravert H, Wagner HN Jr, Gjedde A:D2 dopamine receptors in Tourette's syndrome and manic depressive illness. J. Nucl. Med., 29: 820, 1988.

(41) Singer HS, Hahn IH, Nelson E, Moran T: Tourette Syndrome: A neurochemical analysis

of cortical brain regions. Soc. Neurosci. Abstr., 15 (Part 2):1333, 1989. (42) Singer HS, Hahn IH, Nelson E, Moran T: Tourette Syndrome: A neurochemical analysis

of cortical brain regions. Ann. Neurol. 26:466, 1989. (43) Wong DF, Pearlson GD, Young LT, Singer H, Villemagne V, Tune L, Ross C, Dannals

RF, Links JM, Chan B, Wilson AA, Ravert HT, Wagner HN Jr, Gjedde A: D2 dopamine receptors are elevated in neuropsychiatric disorders other than schizophrenia. J Cerebral Blood Flow Metabol., 9:S593, 1989.

(44) Allen R, Singer H, Brown J, Salam M, Hahn IH: Report Sleep Related Disturbances in

Children with Tourette's Syndrome (TS) with and without Attention Deficit Hyperactivity Disorder (ADHD). 4th Annual Meeting Association of Professional Sleep Societies Minneapolis, MN, 1990.

(45) Wong DF, Shaya E, Singer H, Naidu S, Harris J, Moser H, Dannals RF, Wilson AA,

Ravert HT, Wagner HN Jr: PET In-Vivo Assessment of D2 Dopamine Receptors in Tourette Syndrome and Two Neurodegenerative Disorders. The Society of Nuclear Medicine 37th Annual Meeting, 1990.

(46) Singer HS, Allen R, Brown J, Salam M, Hahn I-H: Sleep disorders in Tourette syndrome:

A primary or related problem. Ann Neurol 28:424, 1990. (47) Singer HS, Hahn I-H, Moran TH: Abnormalities of dopaminergic markers in postmortem

striatal specimens from patients with Tourette syndrome. Ann Neurol 28:441, 1990. (48) Singer HS, Hahn I-H, Walker L, Lowenstein P, Slesinger P, Price D, Coyle J: Ontogeny

of choline uptake sites and M1 muscarinic receptors in the baboon hippocampal formation. Soc Neurosci Abst 16: Part 2, p 1290, 1990.

(49) Pardo CA, Martin LJ, Dixon AM, Singer HS, Troncoso JC:Infantile neuroaxonal

dystrophy with Alzheimer-like pathology:A model for the development of senile plaques. Neurology 41 (Suppl. 1):197-198, 1991.

(50) Rosenberg LA, Singer HS, Brown, J: Behavior problems and severity of tics: a

curvilinear relationship. American Psychological Association, 1991.

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(51) Denckla BA, Aylward EH, Harris EL, Reader MJ, Singer HS, Reiss AL, Bryan RN, Chase GA: Executive function and volume of the basal ganglia in children with Tourette Syndrome and attention-deficit disorder (TS-ADHD). Ann Neurol 30:476, 1991.

(52) Singer HS, Dickson J: Abnormal synaptic neurotransmission: A pathogenetic mechanism

for neurologic dysfunction in ganglioside storage disease. Ann Neurol 30:467, 1991. (53) Singer HS, Brown J, Quaskey S, Mellits ED, Denckla MG, Rosenberg LA: The treatment

of attention-deficit hyperactivity disorder in Tourette syndrome. A double-blind placebo-controlled study with clonidine and desipramine. Ann Neurol 30:485, 1991.

(54) Wong HS, Singer HS, Shaya E, Brandt J, Chen C, Brown J, Dannals RF, Ravert HT,

Wilson AA, Wagner HN, Jr.:D2 dopamine receptor densities measured by 11C-NHST PET in Tourette syndrome.

(55) Singer HS, Dickson J: Further analysis of the second messenger hypothesis in Tourette

syndrome. Ann Neurol 32:431, 1992. (56) Singer HS, Dickson J, Catterall M, Troncoso J: Characterization of human glioma and

medulloblastoma cell cultures. Ann Neurol 32:470, 1992. (57) Fisher P, Singer HS, Wechsler DS, Posner JB. Anti-Hu antineuronal antibody in

neuroblastoma associated opsoclonus-myoclonus syndrome. Ann Neurol 32:441, 1992. (58) Harris EL, Singer HS, Reader MJ, Aylward E, Reiss A, Bryan RN, Chase GA, Denckla

MB. Executive function in children with Tourette syndrome, Am Soc Human Genetics, 1992.

(59) Singer HS, Reiss AL, Brown J, Aylward EH, Shih B, Chee E, Harris EL, Reader MJ,

Chase GA, Bryan RN, Denckla MB. Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. American Academy of Neurology, New York, April 1993.

(60) Vandenbergh DJ, Persico AM, Gelernter J, Bird GS, Crowe R, Surratt C, Kurlan R,

Hurko O, Singer H, Kidd KK, Uhl GR. Dopamine and vesicular transporter gene markers in neuropsychiatric disorders. Soc Neurosci Abst 19:201, 1993.

(61) Singer HS, Harley E, Moran TH, Costello A, Troncoso J. The effect of sodium phenyl butyrate on human glioma (U373) and medulloblastoma (D324) cell cultures. Soc Neurosci Abstracts 19:1728, 1993. (62) Singer HS, Waranch HR, Brown J, Carson K, Mellits D. Relaxation therapy: An

alternative treatment for Tourette's syndrome? Ann Neurol 34:439, 1993. (63) Bergin A, Carson K, Brown J, Singer HS. Assessment of instruments measuring tic

severity in Tourette syndrome. Pediatr Neurol 11: 122-123, 1994.

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(64) Singer HS, Abrams MT, Baumgardner TL, Colli MJ, Reiss AL. Morphology of corpus callosum in children with Tourette syndrome. Ann Neurol 36:526, 1994. (65) Singer HS, Wong DF, Brown J, Marenco S, Yung B, Yokoi F, Chan B, Ravert H,

Mathews W, Musachio J, Dannals RF. Dopamine transporter reuptake sites in Tourette syndrome. Ann Neurol 36:504-505, 1994.

(66) Singer HS, Martinie D, Hilton J, Colvin M. Growth inhibition of glioblastoma

multiforme with sodium phenyl butyrate: in vitro and xenograft investigations. Ann Neurol 36:525, 1994.

(67) Singer HS, Szymanski S, Giuliano J, et al. Increased intrasynaptic dopamine release in Tourette's syndrome. Ann Neurol 42: 528, 1997.

Sallee F, Kurlan R, Goetz C, Singer H, Leckman J, Chappell, P. The tolerability and efficacy of ziprasidone in the treatment of children and adolescents with Tourette’s syndrome. ACNP meeting, Hawaii, 1997.

(69) Singer HS, Giuliano J, Hanson B, Kiessling L. Antineuronal antibodies, streptococcal infections, and Tourette syndrome. Neurology, 1997. (70) Singer HS, Giuliano J, Hansen B, et al. Antibodies to human basal ganglia and

antistreptococcal antibodies in Tourette's syndrome. Ann Neurol 42:533, 1997. (71) Singer HS, Zimmerman A, Giuliano J, Abrams M, Reiss A, Denckla M. Volumetric

MRI analysis and the effect of gender on children with Tourette syndrome. Child Neurology Society, 1998

(72) Giuliano JD, Zimmerman A, Walkup JT, Singer HS. Prevalance of “PANDAS-by

history in a consecutive series of community referred children evaluated for tics. Child Neurology Society 1998.

(73) Giuliano JD, Zimmerman A, Walkup JT, Singer HS. Prevalence of pediatric

autoimmune neuropsychiatric disorders associated with a streptococcal infection by history in a consecutive series of community referred children evaluated for tics. Ann Neurol. 44:556, 1998.

(74) Singer HS, Zimmerman A, Giuliano J, Abrams M, Reiss A, Denckla M. Volumetric

magnetic resonance imaging analysis and the effect of gender on children with Tourette’s syndrome. Ann Neurol. 44:552, 1998.

(75) Sehgal N, McDermott M, Singer A, Goetz C, Stebbins G, Marshall F, Rahman E, Brower

C, Orme C, Kurlan R. Short vs longer term pimozide therapy in Tourette’s syndrome. Movt Disord 13: Suppl 2, 137, 1998.

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(76) Salle F, Kurlan R, Goetz C, Singer H, Leckman J, Chappell P. The tolerability and efficacy of ziprasidone in the treatment of children and adolescent with Tourette’s syndrome. 3rd International Scientific Symposium on Tourette Syndrome, June 1999.

(77) Mostofsky S, Wendlandt J, Cutting L, Denckla MB, Singer HS. Corpus callosum

measurements in girls with Tourette syndrome. 3rd International Scientific Symposium on Tourette Syndrome, June 1999.

(78) Kates WR, Mostofsky S, Choe Y, Abrams MT, Kaufman WE, Singer HS, Denckla MB.

Absence of age-related changes in cortical white matter in children with Tourette syndrome. 3rd International Scientific Symposium on Tourette Syndrome. New York, June 1999.

(79) Mahone EM, Koth C, Schuerholz L, Singer HS, Denckla MB. Clustering and

disinhibition on fluency and recall measures in Tourette syndrome and/or ADHD. J International Neuropsychological Society 1999; 5:98.

(80) Mahone EM, Cutting L, Cerrone D, Hagelthorn K, Hiemenz J, Cirino P, Singer H,

Denckla MB.Validity of the Behavior Rating Inventory for Executive Function in Children with ADHD and/or Tourette syndrome. International Neuropsychological Society, Feb 2000.

(81) Cutting L, Koth C, Mostofsky S, Mahone M, Hagelthorn K, Hiemenz J, Cerrone P,

Cirino P, Singer H, Denckla M. Examination of subtypes of executive function (EF) deficits in attention deficit hyperactivity disorder. International Neuropsychological Society, Feb 2000.

(82) Mostofsky SH, Singer HS, Lasker A, Denckla MB, Zee D. Oculomotor findings in males

with Tourette syndrome. Ann Neurol 2000;48:542-543. (83) Singer HS, Krieger M, Wendlandt JT, Giuliano J. Suppression of tics with baclofen:

Double-blind, placebo-controlled, crossover clinical trial. Ann Neurol 2000 ;48:544-545.

(84) Wendlandt JT, Grus FH, Augustin AJ, Hansen BH, Singer HS. Autoantibody repertoires

in children with Tourette's syndrome: Multivariate statistical comparison by discriminant analysis of activity against human striatum, muscle, and a neuroblastoma cell line. Ann Neurol 2000, 48:512.

(85) Singer HS, Loiselle CR, Kwak NG, Cunningham MW, Kaplan EL, Moran TH. Effect of

microinfused sera from children with postinfectious neuropsychiatric disorders associated with streptococcal infection and Tourette syndrome and antibodies against streptococcal M5 protein into rodent striatum. Ann Neurol 2001; Suppl 1:S117.

(86) Brasic JR, Osman M, Gay O, Arkles JS, Kalaff A, Belle AS, Singer HS, Wong DF.

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Characteristics of volunteers for neuroimaging studies of Tourette's disorder. Mov Disord 2001;16 (Suppl 1):S47.

(87) Loiselle CR, Moran TH, Swedo SE, Singer HS. Investigations of immune mechanisms

in children with PANDAS and Tourette syndrome: Microinfusion of sera into rodent striatum. Neurology 2002;58(Suppl 3):A371-A372.

(88) Singer HS, Loiselle CR, Wendlandt JT, Swedo SE, Grus FT. Antineuronal antibodies in

Sydenham's chorea and PANDAS: an ELISA and Western blot analysis. Neurology 2002;58(Suppl 3):A372.

(89) Lee O, Loiselle CR, Becker KG, Kwak NG, Comi AM, Singer HS. Neurochemical

markers and microarrays in postmortem Tourette syndrome putamen and brain area 9. Ann Neurol 2002; 52 (Suppl 1):S115.

(90) Mahone EM, Freeman D, Prahme C, Singer HS. Clinical features of physiologic

stereotypies in children. Ann Neurol 2003; 54 (Suppl 7):S145 (91) Kates W, Lanham DC, Singer HS. Frontal white matter reductions in healthy boys with

complex stereotypies. Ann Neurol 2003; 54 (Suppl 7):S144-S145. (92) Miller J, Singer HS, Waranch HR. Behavior therapy for the treatment of stereotypic

movements in non-autistic children, submitted Ann Neurol 2004; 56 (Suppl 8):S109. (93) Hong JJ, Rippel CA, Yoon DY, Pardo CA, Singer HS. Comparison of anti-basal ganglia

antibodies in PANDAS and Tourette syndrome. Ann Neurol 2004; 56 (Suppl 8):S129. (94) Rippel CA, Hong JJ, Pardo CA, Singer HS. Methodological factors are important in the study of anti-basal ganglia antibodies, submitted Ann Neurol 2004; 56 (Suppl 8):S106. (95) Singer HS, Mink JW, Hallett JJ, Lombroso PJ. Is the microinfusion of antineuronal antibodies into rodent striatum a valid method to evaluate autoimmunity in pediatric movement disorders? Ann Neurol 2004; 56 (Suppl 8):S89. (96) Zhou Y, Brasis JR, Ye W, Dogen AS, Hilton J, Singer HS, Wong DF. Quantification of cerebral serotonin binding in normal controls and subjects with Tourette’s syndrome using [11C]MDL 100,907 and (+)[11C]McN 5652 dynamic PET with parametric imaging approach. NeuroImage 2004; 22 (Suppl 2):T98-99. (97) Singer HS, Hong JJ, Yoon DY, Williams PN, Rippel CA, Pardo CA. Comparison of anti- basal ganglia antibodies in PANDAS and Tourette syndrome. Neurology 2005; 64 (Suppl 1): A199-200

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(98) Yoon DY, Rippel CA, Williams PN, Kobets AJ, Lee JE, Morris MM, Yao Y, Singer HS. Dopaminergic polymorphisms in Tourette syndrome patients. Neurology 2005; 64 (Suppl 1): A200

(1) Morris CM, Williams PN, Hong JJ, Zimmerman AW, Singer HS. Autoantibodies in

children with autism. Child Neurology Society meeting, Ann Neurol 2005; 58 (Suppl 9): S101.

(2) Williams PN, Yoon DY, Morris CM, Singer HS. Putative autoreactive antigens in Tourette syndrome and PANDAS. Ann Neurol 2005; 58 (Suppl 9): S89.

(3) Yoon DY, Rippel CA, Kobets AJ, Lee JE, Williams PN, Morris CM, Shugart YY,

Bridges DD, Singer HS. Association between the dopamine transporter gene (SLC6A3) DdeI polymorphism and Tourette syndrome. Ann Neurol 2005; 58 (Suppl 9): S91.

(102) Wong DF, Brasic JR, Kuwabara H, Zhou D, Schretlen D, Kumar A, Ye W, Alexander M, Nandi A, Bell-Warren K, Gjedde A, Grace A, Singer H. Abnormalities of dopamine and serotonin neuroreceptors with PET in Tourette syndrome. Program No. 1012.15.2005 Abstract Viewer/Itinary Planner. Washington DC:Society for Neuroscience, 2005. Online. Major Invited Speeches 1992 – Present October 10-14, 1992: American Academy of Pediatrics, San Francisco October 23, 1992: Child Neurology Society, New Orleans November 13, 1992: University of California, San Diego November 24, 1992: DC Children’s Hospital Washington, DC January 22, 1993: Emory University October, 1993: Child Neurology Society, Orlando August 1994: Norge Tourette Syndrome Conference (Norway) August 1994: Visiting Professor, National Children’s Hospital, Oslo, Norway October 1994: Child Neurology Society, San Francisco November 8, 1994: Movement Disorder Society, Orlando, FL Nov. 30, 1994: INOVA Conference, Fairfax, VA April 10, 1995: American Academy of Pediatrics 1995: Franklin Square Hospital 1995: AI Dupont Hospital 1995: Akron Children’s Hospital October 1996: Visiting Professor University of New Mexico New Mexico Pediatric Society November 1996: DC Children’s Hospital December 1996: Mt. Washington Hospital August 2, 1997: Michigan Pediatric Society, East Lansing, MI November 1, 1997: Child Neurology Society, Phoeniz, AZ

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November 3, 1997: American Academy Pediatrics, June 1998: Casey Foundation, Baltimore October 13, 1998: Movement Disorder Society, New York October 16, 1998: TSA Medical Symposium, New York November 18, 1998: Walter Reed Hospital, Washington, DC

December 18, 1998: American College Neuropsychopharmacology, San Juan, PR January, 1999: Visiting Professor, Kapiolani Women and Children’s Medical Center, Honolulu, Hawaii April 2, 1999: Cleveland Clinic, Cleveland, OH April 17, 1999: Eastern VA Medical College, Norfolk, VA May, 1999: Visiting Professor, University Hospital, Reykjavik, Iceland June 5, 1999: 3rd International TS Scientific Meeting, New York June 17-18, 1999: Visiting Professor, Cleveland Metropolitan General Hospital, Cleveland, OH October 16, 1999: Child Neurology Society, Memphis, TN October 20, 1999: Howard University, Washington, DC Nov.-Dec., 1999: Visiting Professor, University Sao Paulo, Brazil December 16, 1999: American College Neuropsychopharmacology, Mexico March 2, 2000: DC Children’s Hospital, Washington, DC May 11, 2000: Medical College of Virginia, Richmond, VA May 24, 2000: Howard County General Hospital, Columbia, MD June 28, 2000: University Medicine and Dentistry New Jersey, Newark, NJ September 18, 2000: Toronto Sick Kids, Toronto September 26, 2000: Sinai Hospital, Baltimore

October 13, 2000: European Foundation of Neurological Sciences, Copenhagen, October 27, 2000: Child Neurology Society, St. Louis, MO January 26, 2001: Baylor University, Houston, Texas April 27, 2001: International TS Meeting, Amsterdam May 5, 2001: American Academy Neurology, Philadelphia July 5, 2001: Lecture, International Congress of Biological Psychiatry, Berlin, Germany August 11, 2001: Speaker, University of Rochester, Rochester NY October 20, 2001: Lecture, Child Neurology Society, Victoria, British Columbia October 24, 2001: Speaker, DuPont Children’s Hospital, Wilmington, DE November 7, 2001: Lecture, DC Children’s Hospital, Washington, DC March 29, 2002: Speaker, Hershey Medical Center, Hershey, PA April 16, 2002: Lecture, American Academy Neurology, Denver, CO May 15-16, 2002: Visiting Professor, Oregon Health Sciences Univ., Portland, OR September 23, 2002: Lecture, International Child Neurology Society, Beijing China September 27, 2002: Speaker, Tourette Syndrome Conference, Tokyo, Japan October 10, 2002: Child Neurology Society, Washington, DC November 13, 2002: Symposium, Movement Disorder Society, Miami, FL March 7, 2003: Speaker, Tourette Syndrome Conference, Phoenix, AZ April 4, 2003: Lecture (2) American Academy of Neurology, Honolulu, Hawaii

June 19-20 2003: Canadian Royal Society Guest speaker, Canadian Congress of Neurological Specialties, Quebec City, Canada

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October 1, 2003 Symposium, Child Neurology Society, Miami, FL November 3, 2003 Lecture (2) American Academy of Pediatrics, New Orleans, LA Nov 12-13, 2003 Preston Robb Guest Lecturer, Montreal Children’s Hospital,

Montreal, Canada Nov 17, 2003 Talk, Pediatric Neurology Associates, Atlanta, GA February 11, 2004 Guest Lecturer, International Congress of Biological Psychiatry, Sydney, Australia April 22, 2004 Lecture, Pediatric Trends, Johns Hopkins Hospital, Baltimore, MD April 26, 2004 Lecture, American Academy of Neurology, San Francisco, CA June 9-10, 2004 Guest Lecturer, Scandanavian Pediatric Society, Silkebord, Denmark June 17, 2004 Debate, Movement Disorder Society, Rome, Italy June 25-27, 2004 Lecture (2) International Tourette Syndrome Meeting, Cleveland, Ohio September 23, 2004 Lecture, Pediatrics for the Practitioner, Baltimore, MD October 14-17, 2004 Symposium (2), Child Neurology Society, Ottawa, Canada January 6, 2005 Johns Hopkins Neurology Grand Rounds March 5-8, 2005 Symposium (2) Movement Disorder Society, New Orleans April 11-16, 2005 Course lectures (2) American Academy of Neurology, Miami June 10, 2005 Seventh Johns Hopkins Autoimmunity Day Oct 5, 2005 Tourette Syndrome Symposium, CNS, Los Angeles December 15,2005 Neurology Grand Rounds, Johns Hopkins Hospital