1

Curriculum Vitae

Mamoru Kato, Ph.D.

National Cancer Center

5-1-1, Tsukiji, Chuuoo-ku

Tokyo 104-0045, Japan

E-mail: mamkato@ncc.go.jp

Tel: +81-3-3542-2511 (ext. 3124)

Web page: http://www.ne.jp/asahi/mk/home/

Education and Employment

2013/07 – Present Head, Dept. of Bioinformatics, National Cancer Center Japan

2012/06 – Present Laboratory Head, Div. of Cancer Genomics,

National Cancer Center Japan

2009/04 – 2012/05 Computational Postdoctoral Fellow,

Cold Spring Harbor Laboratory, USA

2005/04 – 2008/03 Adjunct Lecturer in School of Medicine, Keio University, Japan

2004/04 – 2009/03 Research Scientist, RIKEN, Japan

2004/03 Ph.D. Degree in Physics, University of Tokyo, Japan

2003/04 – 2003/08 Research Assistant, Cold Spring Harbor Laboratory, USA

2002/02 – 2003/03 Visiting Student, Cold Spring Harbor Laboratory, USA

2001/04 – 2003/03 Research Fellow of the Japan Society

for the Promotion of Science for Young Scientists

2000/04 – 2004/03 Ph.D. Program, University of Tokyo, Japan

2000/03 M.S. in Physics, University of Tokyo, Japan

1998/03 B.S. in Physics, Kyoto University, Japan

Last updated: March, 2017

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Specialties

Bioinformatics

Computational biology

Peer-reviewed Papers

2017

Shintaro Fukushima, Satoshi Yamashita, Hisato Kobayashi, Hirokazu Takami,

Kohei Fukuoka, Taishi Nakamura, Kai Yamasaki, Yuko Matsushita, Hiromi

Nakamura, Yasushi Totoki, Mamoru Kato, Tomonari Suzuki, Kazuhiko Mishima,

Takaaki Yanagisawa, Akitake Mukasa, Nobuhito Saito, Masayuki Kanamori,

Toshihiro Kumabe, Teiji Tominaga, Motoo Nagane, Toshihiko Iuchi, Koji

Yoshimoto, Masahiro Mizoguchi, Kaoru Tamura, Keiichi Sakai, Kazuhiko

Sugiyama, Mitsutoshi Nakada, Kiyotaka Yokogami, Hideo Takeshima, Yonehiro

Kanemura, Masahide Matsuda, Akira Matsumura, Kazuhiko Kurozumi, Keisuke

Ueki, Masahiro Nonaka, Akio Asai, Nobutaka Kawahara, Yuichi Hirose, Tatusya

Takayama, Yoichi Nakazato, Yoshitaka Narita, Tatsuhiro Shibata, Masao Matsutani,

Toshikazu Ushijima, Ryo Nishikawa, Koichi Ichimura, On behalf of The

Intracranial Germ Cell Tumor Genome Analysis Consortium (The

iGCTConsortium)

Genome‑wide methylation profiles in primary intracranial germ cell tumors

indicate a primordial germ cell origin for germinomas

Acta Neuropathologica, 2017, 133, 445-462.

Tsuyoshi Takahashi, Asmaa Elzawahry, Sachiyo Mimaki, Eisaku Furukawa, Rie

Nakatsuka, Hiromi Nakamura, Takahiko Nishigaki, Satoshi Serada, Tetsuji Naka,

Seiichi Hirota, Tatsuhiro Shibata, Katsuya Tsuchihara, Toshirou Nishida, and

Mamoru Kato

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal

stromal tumors

Genes, Chromosomes & Cancer, 2017, 56, 303-313.

Naofumi Asano, Akihiko Yoshida, Sachiyo Mitani, Eisuke Kobayashi, Bunsyo

Shiotani, Motokiyo Komiyama, Hiroyuki Fujimoto, Hirokazu Chuman, Hideo

Morioka, Morio Matsumoto, Masaya Nakamura, Takashi Kubo, Mamoru Kato,

Takashi Kohno, Akira Kawai, Tadashi Kondo, and Hitoshi Ichikawa

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Frequent amplification of receptor tyrosine kinase genes in

well-differentiated/dedifferentiated liposarcoma

Oncotarget, 2017, 8, 12941-12952.

Hideyuki Hayashi, Takashi Kohno, Hideki Ueno, Nobuyoshi Hiraoka, Shunsuke

Kondo, Motonobu Saito, Yoko Shimada, Hitoshi Ichikawa, Mamoru Kato,

Tatsuhiro Shibata, Chigusa Morizane, Yasunari Sakamoto, Kazuaki Shimada,

Yoshito Komatsu, Naoya Sakamoto, and Takuji Okusaka,

Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and

SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic

Biomarker for Pancreatic Cancer

Pancreas, 2017, 46, 335-340.

2016

Yuko Tanabe, Hitoshi Ichikawa, Takashi Kohno, Hiroshi Yoshida, Takashi Kubo,

Mamoru Kato, Satoru Iwasa, Atsushi Ochiai, Noboru Yamamoto, Yasuhiro

Fujiwara, and Kenji Tamura

Comprehensive screening of target molecules by next-generation sequencing in

patients with malignant solid tumors: guiding entry into phase I clinical trials

Molecular Cancer, 2016, 15, 73-77.

Koichi Ichimura, Shintaro Fukushima, Yasushi Totoki, Yuko Matsushita, Ayaka

Otsuka, Arata Tomiyama, Tohru Niwa, Hirokazu Takami, Taishi Nakamura,

Tomonari Suzuki, Kohei Fukuoka, Takaaki Yanagisawa, Kazuhiko Mishima, Yoichi

Nakazato, Fumie Hosoda, Yoshitaka Narita, Soichiro Shibui, Akihiko Yoshida,

Akitake Mukasa, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji

Tominaga, Keiichi Kobayashi, Saki Shimizu, Motoo Nagane, Toshihiko Iuchi,

Masahiro Mizoguchi, Koji Yoshimoto, Kaoru Tamura, Taketoshi Maehara,

Kazuhiko Sugiyama, Mitsutoshi Nakada, Keiichi Sakai, Yonehiro Kanemura,

Masahiro Nonaka, Akio Asai, Kiyotaka Yokogami, Hideo Takeshima, Nobutaka

Kawahara, Tatsuya Takayama, Masahiro Yao, Mamoru Kato, Hiromi Nakamura,

Natsuko Hama, Ryuichi Sakai, Toshikazu Ushijima, Masao Matsutani, Tatsuhiro

Shibata, Ryo Nishikawa, The Intracranial Germ Cell Tumor Genome Analysis

Consortium

Recurrent neomorphic mutations of MTOR in central nervous system and

testicular germ cell tumors may be targeted for therapy

Acta Neuropathologica, 2016, 131, 889–901

Akihiro Fujimoto*, Mayuko Furuta*, Yasushi Totoki*, Tatsuhiko Tsunoda*,

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Mamoru Kato*, Yuichi Shiraishi, Hiroko Tanaka, Hiroaki Taniguchi, Yoshiiku

Kawakami, Masaki Ueno, Kunihito Gotoh, Shun-ichi Ariizumi, Christopher P

Wardell, Shinya Hayami, Toru Nakamura, Hiroshi Aikata, Koji Arihiro, Keith A

Boroevich, Tetsuo Abe, Kaoru Nakano, Kazuhiro Maejima, Aya Sasaki-Oku, Ayako

Ohsawa, Tetsuo Shibuya, Hiromi Nakamura, Natsuko Hama, Fumie Hosoda,

Yasuhito Arai, Shoko Ohashi, Tomoko Urushidate, Genta Nagae, Shogo Yamamoto,

Hiroki Ueda, Kenji Tatsuno, Hidenori Ojima, Nobuyuki Hiraoka, Takuji Okusaka,

Michiaki Kubo, Shigeru Marubashi, Terumasa Yamada, Satoshi Hirano, Masakazu

Yamamoto, Hideki Ohdan, Kazuaki Shimada, Osamu Ishikawa, Hiroki Yamaue,

Kazuki Chayama, Satoru Miyano, Hiroyuki Aburatani, Tatsuhiro Shibata, and

Hidewaki Nakagawa

Whole genome mutational landscape and characterization of non-coding and

structural mutations in liver cancer

Nature Genetics, 2016, 48, 500-509

Ryutaro Uchi, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Hidenari

Hirata, Keishi Sugimachi, Genta Sawada, Takeshi Iwaya, Junji Kurashige, Yoshiaki

Shinden, Tomohiro Iguchi, Hidetoshi Eguchi, Kenichi Chiba, Yuichi Shiraishi,

Genta Nagae, Kenichi Yoshida, Yasunobu Nagata, Hiroshi Haeno, Hirofumi

Yamamoto, Hideshi Ishii, Yuichiro Doki, Hisae Iinuma, Shin Sasaki, Satoshi

Nagayama, Kazutaka Yamada, Shinichi Yachida, Mamoru Kato, Tatsuhiro Shibata,

Eiji Oki, Hiroshi Saeki, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara, Shizuo

Komune, Masaki Mori, Yutaka Suzuki, Ken Yamamoto, Hiroyuki Aburatani, Seishi

Ogawa, Satoru Miyano, and Koshi Mimori

Integrated multiregional analysis proposing a new model of colorectal cancer

evolution

PLOS Genetics, 2016, 12, e1005778.1-24

Shinichi Yachida, Laura D. Wood, Masami Suzuki, Erina Takai, Yasushi Totoki,

Mamoru Kato, Claudio Luchini, Yasuhito Arai, Hiromi Nakamura, Natsuko Hama,

Asmaa Elzawahry, Fumie Hosoda, Tomoki Shirota, Nobuhiko Morimoto, Kunio

Hori, Jun Funazaki, Hikaru Tanaka, Chigusa Morizane, Takuji Okusaka, Satoshi

Nara, Kazuaki Shimada, Nobuyoshi Hiraoka, Hirokazu Taniguchi, Ryota Higuchi,

Minoru Oshima, Keiichi Okano, Seiko Hirono, Masamichi Mizuma, Koji Arihiro,

Masakazu Yamamoto, Michiaki Unno, Hiroki Yamaue, Matthew J. Weiss,

Christopher L. Wolfgang, Toru Furukawa, Hitoshi Nakagama, Bert Vogelstein,

Tohru Kiyono, Ralph H. Hruban, and Tatsuhiro Shibata

Genomic sequencing identifies ELF3 as a driver of ampullary carcinoma

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Cancer Cell, 2016, 29, 229-240

2015

Erina Takai, Yasushi Totoki, Hiromi Nakamura, Chigusa Morizane, Satoshi Nara,

Natsuko Hama, Masami Suzuki, Eisaku Furukawa, Mamoru Kato, Hideyuki

Hayashi, Takashi Kohno, Hideki Ueno, Kazuaki Shimada, Takuji Okusaka, Hitoshi

Nakagama, Tatsuhiro Shibata, and Shinichi Yachida

Clinical utility of circulating tumor DNA for molecular assessment in

pancreatic cancer

Scientific Reports, 2015, 5, 18425.1-10

Hiromi Nakamura, Yasuhito Arai, Yasushi Totoki, Tomoki Shirota, Asmaa

Elzawahry, Mamoru Kato, Natsuko Hama, Fumie Hosoda, Tomoko Urushidate,

Shoko Ohashi, Nobuyoshi Hiraoka, Hidenori Ojima, Kazuaki Shimada, Takuji

Okusaka, Tomoo Kosuge, Shinichi Miyagawa, Tatsuhiro Shibata

Genomic spectra of biliary tract cancer

Nature Genetics, 2015, 47, 1003-1010

Motonobu Saito, Yoko Shimada, Kouya Shiraishi, Hiromi Sakamoto, Koji Tsuta,

Hirohiko Totsuka, Suenori Chiku, Hitoshi Ichikawa, Mamoru Kato, Shun-ichi

Watanabe, Teruhiko Yoshida, Jun Yokota, Takashi Kohno

Development of lung adenocarcinomas with exclusive dependence on oncogene

fusions.

Cancer Research, 2015, 75, 2264-2271

Masataka Takenaka, Motonobu Saito, Reika Iwakawa, Nozomu Yanaihara, Misato

Saito, Mamoru Kato, Hitoshi Ichikawa, Tatsuhiro Shibata, Jun Yokota, Aikou

Okamoto, Takashi Kohno

Profiling of actionable gene alterations in ovarian cancer by targeted deep

sequencing.

International Journal of Oncology, 2015, 46, 2389-2398

Kousuke Ishino, Tatsuya Kato, Mamoru Kato, Tatsuhiro Shibata, Masatoshi

Watanabe, Keiji Wakabayashi, Hitoshi Nakagama, Yukari Totsuka

Comprehensive DNA adduct analysis reveals pulmonary inflammatory

response contributes to genotoxic action of magnetite nanoparticles

Int. J. Mol. Sci., 2015, 16, 3474-3492

2014

Yasushi Totoki, Kenji Tatsuno, Kyle R Covington, Hiroki Ueda, Chad J Creighton,

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Mamoru Kato, Shingo Tsuji, Lawrence A Donehower, Betty L Slagle, Hiromi

Nakamura, Shogo Yamamoto, Eve Shinbrot, Natsuko Hama, Megan Lehmkuhl,

Fumie Hosoda, Yasuhito Arai, Kim Walker, Mahmoud Dahdouli, Kengo Gotoh,

Genta Nagae, Marie-Claude Gingras, Donna M Muzny, Hidenori Ojima, Kazuaki

Shimada, Yutaka Midorikawa, John A Goss, Ronald Cotton, Akimasa Hayashi,

Junji Shibahara, Shumpei Ishikawa, Jacfranz Guiteau, Mariko Tanaka, Tomoko

Urushidate, Shoko Ohashi, Naoko Okada, Harsha Doddapaneni, Min Wang, Yiming

Zhu, Huyen Dinh, Takuji Okusaka, Norihiro Kokudo, Tomoo Kosuge, Tadatoshi

Takayama, Masashi Fukayama, Richard A Gibbs, David A Wheeler, Hiroyuki

Aburatani & Tatsuhiro Shibata

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

Nature Genetics, 2014, 46, 1267-1273.

Tatsuji Mizukami, Kouya Shiraishi, Yoko Shimada, Hideaki Ogiwara, Koji Tsuta,

Hitoshi Ichikawa, Hiromi Sakamoto, Mamoru Kato, Tatsuhiro Shibata, Takashi

Nakano, Takashi Kohno,

Molecular mechanisms underlying oncogenic RET fusion in lung

adenocarcinoma.

Journal of Thoracic Oncology, 2014, 9, 622-630.

Shintaro Fukushima, Ayaka Otsuka, Tomonari Suzuki, Takaaki Yanagisawa,

Kazuhiko Mishima, Akitake Mukasa, Nobuhito Saito, Toshihiro Kumabe, Masayuki

Kanamori, Teiji Tominaga, Yoshitaka Narita, Soichiro Shibui, Mamoru Kato,

Tatsuhiro Shibata, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura, On behalf

of the Intracranial Germ Cell Tumor Genome Analysis Consortium (iGCT

Consortium)

Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA

expression and chromosomal instability in primary intracranial pure

germinomas

Acta Neuropathologica, 2014, 127, 911-925

Yusuke Suenaga, S. M. Rafiqul Islam, Jennifer Alagu, Yoshiki Kaneko, Mamoru

Kato, Yukichi Tanaka, Hidetada Kawana, Shamim Hossain, Daisuke Matsumoto,

Mami Yamamoto, Wataru Shoji, Makiko Itami, Tatsuhiro Shibata, Yohko Nakamura,

Miki Ohira, Seiki Haraguchi, Atsushi Takatori, Akira Nakagawara.

NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein

That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human

Neuroblastomas.

PLoS Genetics, 2014, 10, e1003996.1-14

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2013 or before

Megha Rajaram, Jianping Zhang, Tim Wang, Jinyu Li, Cem Kuscu, Huan Qi,

Mamoru Kato, Vladimir Grubor, Robert J. Weil, Aslaug Helland, Anne-Lise

Borrenson-Dale, Kathleen R. Cho, Douglas A. Levine, Alan N. Houghton, Jedd D.

Wolchok, Lois Myeroff, Sanford D. Markowitz, Scott W. Lowe, Michael Zhang,

Alex Krasnitz, Robert Lucito, David Mu, and R. Scott Powers

Two distinct categories of focal deletions in cancer genomes.

PLoS ONE, 2013, 8, e66264.1-13.

Mamoru Kato, Seungtai Yoon, Naoya Hosono, Anthony Leotta, Jonathan Sebat,

Tatsuhiko Tsunoda, and Michael Q. Zhang

Inferring haplotypes of copy number variations from high-throughput data

with uncertainty.

G3: Genes, Genomes, Genetics, 2011, the inaugural issue, 35-42.

Mamoru Kato, Takahisa Kawaguchi, Shumpei Ishikawa, Takayoshi Umeda,

Reiichiro Nakamichi, Michael H Shapero, Keith W Jones, Yusuke Nakamura,

Hiroyuki Aburatani, and Tatsuhiko Tsunoda

Population-genetic nature of copy number variations in the human genome.

Human Molecular Genetics, 2010, 19, 761-773.

Naoya Hosono, Mamoru Kato, Kazuma Kiyotani, Taisei Mushiroda, Sadaaki Takata,

Hiroko Sato, Hanae Amitani, Yumiko Tsuchiya, Keiko Yamazaki, Tatsuhiko

Tsunoda, Hitoshi Zembutsu, Yusuke Nakamura, and Michiaki Kubo

CYP2D6 genotyping for functional-gene dosage analysis by allele copy number

detection.

Clinical Chemistry, 2009, 55, 1546-1554.

Eiichiro Nagata, Hidenori Hattori, Mamoru Kato, Saiko Ogasawara, Shigeaki

Suzuki, Mamoru Shibata, Toshihiko Shimizu, Junichi Hamada, Takashi Osada, Rie

Takaoka, Masataka Kuwana, Tatsuhiko Tsunoda, Sadakazu Aiso, Shunya Takizawa,

Norihiro Suzuki, Shigeharu Takagi

Identification of biomarkers associated with migraine with aura.

Neuroscience Research, 2009, 64, 104-110.

Mamoru Kato, Yusuke Nakamura, and Tatsuhiko Tsunoda

An algorithm for inferring complex haplotypes in a region of copy number

variation.

The American Journal of Human Genetics, 2008, 83, 157-169.

Mamoru Kato, Yusuke Nakamura, and Tatsuhiko Tsunoda

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MOCSphaser: a haplotype inference tool from a mixture of copy number

variation and single nucleotide polymorphism data.

Bioinformatics, 2008, 24, 1645-1646.

Mamoru Kato, Fuyuki Miya, Yonehiro Kanemura, Toshihiro Tanaka, Yusuke

Nakamura, and Tatsuhiko Tsunoda

Recombination rates of genes expressed in human tissues.

Human Molecular Genetics, 2008, 17, 577-586.

Mamoru Kato and Tatsuhiko Tsunoda

MotifCombinator: a web-based tool to search for combinations of

cis-regulatory motifs.

BMC Bioinformatics, 2007, 8, (100) 1-9.

Mamoru Kato, Akihiro Sekine, Yozo Ohnishi, Todd A. Johnson, Toshihiro Tanaka,

Yusuke Nakamura, and Tatsuhiko Tsunoda

Linkage disequilibrium of evolutionarily conserved regions in the human

genome.

BMC Genomics, 2006, 7, (326) 1-8.

Mamoru Kato, Naoya Hata, Nilanjana Banerjee, Bruce Futcher, and Michael Q

Zhang

Identifying combinatorial regulation of transcription factors and binding

motifs.

Genome Biology, 2004, 5, (R56) 1-13.

Mamoru Kato, Tatsuhiko Tsunoda, and Toshihisa Takagi

Inferring genetic networks from DNA microarray data by multiple regression

analysis.

Genome Informatics, 2000, 11, 118-128.

Review Articles

Mamoru Kato

The current status and future prospects of biomarker exploration for cancer

by bioinformatics analysis

Pharma Medica (in Japanese), 2016, 34, 45-51

Mamoru Kato

Data analysis of single-cell sequencing

Igaku-no Ayumi (Journal of Clinical and Experimental Medicine, in Japanese),

2016, 258, 317-323

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Mamoru Kato

Bioinformatics in cancer clinical sequencing – an emerging field of cancer

personalized medicine

Gan to Kagaku Ryouhou (Japanese Journal of Cancer and Chemotherapy, in

Japanese), 2016, 43, 391-397

Mamoru Kato

Single-cell genomics of cancer.

Igaku-no Ayumi (Journal of Clinical and Experimental Medicine, in Japanese),

2014, 249, 1088-1092

Mamoru Kato and Tatsuhiko Tsunoda

Copy number variation, structural variation, and their analysis methods.

Jikken Igaku (Experimental Medicine, in Japanese), 2009, 27, 167-174.

加藤 護、「バイオインフォマティクス解析によるがんバイオマーカー探索

の現状と今後の展望」、Pharma Medica、2016, 34, 45-51

加藤 護、「一細胞シークエンスのデータ解析」、医学のあゆみ、2016, 258,

317-323

加藤 護、「最新がん個別化医療―臨床シークエンスのバイオインフォマテ

ィクス」、癌と化学療法、2016, 43 (4), 391-397

加藤 護、「一細胞ゲノム解析」、医学のあゆみ、2014, 249, 1088-1092.

加藤 護、角田 達彦、「構造多型、特にコピー数多型とその解析法」、実験

医学、2009, 27, 167-174.

翻訳：加藤 護、「発がんドライバー変異の同定」 by David Tamborero, Abel

Gonzalez-Perez and Nuria Lopez-Bigas, 実験医学、2014, 32, 213-219

Invited Talks

Bioinformatics in Cancer Clinical Sequencing

The 53rd Annual Meeting of Japan Society of Clinical Oncology, Kyoto, Japan,

October 29-31, 2015

A bioinformatics system developed for cancer clinical sequencing in National

Cancer Center, Japan

European Society for Medical Oncology, Madrid, Spain, September 26-30, 2014.

Development of a computational system in cancer clinical sequencing.

2014 Cancer Symposium, Mokpo, Korea, April 15-19, 2014.

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Evolutionary analysis of single-cell sequencing data to detect natural selection in

tumor cells.

71nd Annual Meeting of the Japanese Cancer Association, Sapporo, Japan,

September 19-21, 2012.

Haplotype inference for copy number variations.

The 1st IFIP International Conference on Bioinformatics, Surat, India, March

25-28, 2010.

Platform Presentations

Biomarker exploration by cancer big-data analysis and clinical sequencing

CREST International Symposium on Big Data Application, Tokyo, Japan, January

11-12, 2017

Single-cell sequencing reveals genomic and transcriptomic dynamics during tumor

development in a mouse model.

75rd Annual Meeting of the Japanese Cancer Association, Yokohama, Japan,

October 6-8, 2016.

Cancer omics analysis and clinical sequencing

CREST International Symposium on Big Data Application, Tokyo, Japan, March

4-5, 2016.

Bioinformatics for cancer personalized medicine.

Kato Memorial Foundation Session in BioJapan 2015, Yokohama, Japan, October

15, 2015.

Tumor heterogeneity and single-cell sequencing (sponsored session).

74rd Annual Meeting of the Japanese Cancer Association, Nagoya, Japan, October

8-10, 2015.

Informatics for cancer clinical sequencing in National Cancer Center, Japan

74rd Annual Meeting of the Japanese Cancer Association, Nagoya, Japan, October

8-10, 2015.

Bioinformatics for clinical sequencing and single-cell sequencing.

Mathematics in Cancer Genome Analysis, Mathematical Cooperation Program

2015, Tokyo, Japan, September 30, 2015.

Tumor heterogeneity and single-cell sequencing.

Fluidigm User Meeting 2015, Tokyo, Japan, June 16, 2015.

A bioinformatics system developed for clinical sequencing in National Cancer

Center, Japan (Symposia)

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73rd Annual Meeting of the Japanese Cancer Association, Yokohama, Japan,

September 25-27, 2014.

Case report on wet-dry fusion by a dry researcher who aims at wet research goals

(Workshop)

The 36th Annual Meeting of the Molecular Biology Society of Japan, Kobe, Japan,

December 3-6, 2013.

Cancer-cell evolution revealed by observations at different time points (Symposia).

72rd Annual Meeting of the Japanese Cancer Association, Yokohama, Japan,

October 3-5, 2013.

Detection of DNA variations and fusion genes in cancer by the Ion sequencer

(sponsored session).

Joint Conference on Informatics in Biology, Medicine and Pharmacology, Tokyo,

Japan, October 14-17, 2012.

Evolutionary analysis of single-cell sequencing data in breast cancer.

Genome Informatics, Cold Spring Harbor Laboratory Meeting, New York, USA,

November 2-5, 2011.

Patterns of high-resolution recombination rates in human genes.

Biochemistry and Molecular Biology 2008, Kobe, Japan, December 9-12, 2008.

Patterns of high-resolution recombination rates in human genes.

The 53rd Annual Meeting of the Japan Society of Human Genetics, Yokohama,

Japan, September 27-30, 2008.

Integrative method for identifying combinatorial regulation of transcription factors.

The 26th Annual Meeting of the Molecular Biology Society of Japan (presentation in

symposium), Kobe, Japan, December 10-13, 2003.

Identifying combinatorial regulation of transcription factors and binding sites.

Genome Informatics, Cold Spring Harbor Laboratory Meeting, New York, U.S.A.,

May 7-11, 2003.

Inferring genetic networks from DNA microarray data by multiple regression

analysis.

The Eleventh Workshop on Genome Informatics, Tokyo, Japan, December 18-19,

2000.

Patents

2013/03: Patent granted (US)

Inventor: Mamoru Kato; Assignee: RIKEN

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“Device for the inference of haplotypes, and the program” (for the Application No.

2008-048748)

Registration No. 8401802

2012/11: Patents granted (Japan and international under the PCT)

Inventor: Mamoru Kato; Assignee: RIKEN

“Device for the inference of haplotypes, and the program” (for the international

applications below)

Registration No. 5134397 and 5129809

2008/02: Patent application (Japan)

Inventor: Mamoru Kato; Assignee: RIKEN

“Device for the inference of haplotypes, and the program (method for inferring

haplotypes from the data of copy number variations that do not have polymorphic

nucleotide bases)”

Application No. 2008-048748

2008/02: International patent application (under the PCT, the Patent

Cooperation Treaty)

Inventor: Mamoru Kato; Assignee: RIKEN

(For the two applications below: Application No. 2007-237139 and Application No.

2007-117744)

International Application No. PCT/JP2008/053567

2007/09: Patent application (Japan)

Inventor: Mamoru Kato; Assignee: RIKEN

“Device for the inference of haplotypes, and the program (supplement of

Application No. 2007-117744 below to infer alleles that are represented by integer

copy numbers)”

Application No. 2007-237139

2007/04: Patent application (Japan)

Inventor: Mamoru Kato; Assignee: RIKEN

“Device for the inference of haplotypes, and the program (method for inferring

haplotypes from the data of copy number variations that have polymorphic

nucleotide bases)”

Application No. 2007-117744

2001/08: Patent application (Japan)

Inventor: Mamoru Kato

“Computer readable medium that records a program for inferring the relations of

gene regulations from data on the expression levels and DNA sequences of genes”,

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Application No. 2001-292554

Session Chair

The 75th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan,

October 6-8, 2016.

The 60th Annual Meeting of the Japan Society of Human Genetics, Tokyo, Japan,

October 14-17, 2015

The 36th Annual Meeting of the Molecular Biology Society of Japan, Kobe, Japan,

December 3-6, 2013

2012 Workshop for Young Cancer Scientists, Nagano, Japan, September 5-8, 2012

Teaching Experience

2016: Intensive lecture “Bioinformatics for cancer personalized medicine”

Tokyo Medical and Dental University, Japan

2016: Intensive lecture “Bioinformatics and cancer clinical sequencing”

Graduate School of Medicine, Nagoya University, Japan

2015: Intensive lecture “Bioinformatics for cancer personalized medicine”

Tokyo Medical and Dental University, Japan

2015: Accepting a student in Summer Program between Massachusetts Institute of

Technology and National Cancer Center Japan

2005-2007: Intensive lecture “Body plan from the genomic viewpoint” (on the

Human Genome Project, features of the human genome, post-genome research, and

useful Bioinformatics techniques)

School of Medicine, Keio University, Japan

Seminars (since Laboratory Head at NCC)

2015: “What is bioinformatics?”

Biostatistics Seminar, National Cancer Center Japan

2015: “Visit to MGH”, on clinical sequencing informatics in Massachusetts General

Hospital

International Visit Report, National Cancer Center Japan

2015: “Informatics and information system for cancer clinical sequencing”

Gakuyuukai Seminar, University of Tokyo, Japan.

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2013: “Development of a computer system for clinical sequencing and comparison

of different experimental platforms of next-generation sequencers”

Tohoku Medical Megabank Organization, Tohoku University, Japan.

2012: “Molecular evolution of cancer-cell genomes identified by single-cell

sequencing”

Faculty of Medicine, Kyoto University, Japan.

Articles reported by News Media

2008/08/01: Article on the CNV haplotype inference, in Science News (newspaper

on science news, in Japanese)

2008/07/31: Article on the CNV haplotype inference, in Fuji Sankei Business Eye

(newspaper on industry and economy, in Japanese)

2008/07/23: Article on the CNV haplotype inference, in Nikkei Business Daily

(newspaper on industry and economy, in Japanese)

Other Publications

Mamoru Kato, Naoya Hata, Nila Banerjee, and Michael Q. Zhang. Integrative

method for identifying combinatorial regulation of transcription factors. Genome

Informatics, 2003, 14, 358-359.

Mamoru Kato, Naoya Hata, Nila Banerjee, and Michael Q. Zhang. Inferring

combinatorial regulation of binding sites and transcription factors on gene

expression. Genome Informatics, 2002, 13, 303-304.

Mamoru Kato, Tatsuhiko Tsunoda, and Toshihisa Takagi. Lag analysis of genetic

networks in the cell cycle of budding yeast. Genome Informatics, 2001, 12,

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