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Curriculum Vitae of David Lawrence Page 1 ``` Curriculum Vitae of Mr. David R Lawrence BSc (Hons)., MBBS (Lond)., FRCS (Eng)., FRCS (CTh)., MS (Lond). Current Appointment Consultant in Cardiothoracic Surgery The Heart Hospital, UCL Hospitals NHS Trust

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Page 1: Curriculum Vitae of Mr. David R Lawrence BSc (Hons)., …londonthoracicsurgeons.com/assets/david-lawrence---cv.pdf · Curriculum Vitae of David Lawrence Page 1 ``` Curriculum Vitae

Curriculum Vitae of David Lawrence Page 1

```

Curriculum Vitae

of

Mr. David R Lawrence

BSc (Hons)., MBBS (Lond)., FRCS (Eng)., FRCS (CTh)., MS (Lond).

Current Appointment Consultant in Cardiothoracic Surgery The Heart Hospital, UCL Hospitals NHS Trust

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Personal Details

Name: Mr David Romesh Lawrence Address: 95 Halford Road Ickenham, Uxbridge, Middlesex UB10 8QA Telephone: 01895 232468 (Home) 07956 547017 (Mobile) Fax: 0207 504 8943 E mail: [email protected] Date of Birth: 07 September 1965 Age: 45 years Nationality: British Marital Status: Married GMC Reg Status: Full GMC Reg No: 3486495 MPS No: 180117 UK CCST: In Cardiothoracic Surgery, awarded 24th May 2002 UK Specialist Register: Admitted on 24th June 2002

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2. Education a) Secondary Education September 1981 Wallington High School for Boys, to Croydon Road, June 1983. Wallington, Surrey. Exams passed June 1983 GCE A Level Physics A Mathematics A Chemistry B GCE S Level Mathematics Credit b) University Education Medical School (Pre-clinical): October 1984 Kings' College London, to The Strand Campus, July 1986 London WC2. Intercalated BSc (Pre Clinical): October 1986 Kings' College London, to The Kensington Campus, July 1987 London W2. Medical School (Clinical): September 1987 Kings' College Hospital Medical School, to Denmark Hill, July 1990 London SE5 8RX.

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3. Academic Qualifications June 1986 BSc (Hons) University of London. Basic Medical Sciences and Biochemistry (First Class Honours). June 1990 MBBS University of London (Distinction in Clinical Pharmacology and Therapeutics). January 1992 Primary FRCS Royal College of Surgeons of England. May 1994 Part II FRCS Royal College of Surgeons of England. October 2001 Part III FRCS (CTh) Intercollegiate Specialty Boards Specialty Examination in Cardiothoracic Surgery December 2004 MS (Lond) University of London 4. Scholarships, Prizes and other Awards August 1987 MRC Scholarship for funding of BSc (awarded to the top ten

students at the second MB examination). This year was spent studying molecular genetics.

October 1989 Jocelyn Almond Prize in Diseases of Children (awarded for a

medical student dissertation on the use of gene probes in the prenatal diagnosis of genetically inherited diseases).

November 1998 Grant from the trustees of St George's Hospital, London for one

years' salary and £5000 towards laboratory expenses to study the effect of combining gene therapy and chemotherapy on malignant mesothelioma.

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5. Previous Appointments A. Pre Registration House Officer (1 year)

1. August 1990 to January 1991 - House Physician Firm C and Haematology Kings' College Hospital, London SE5. Consultants: Dr J Costello, Professor John Moxham Professor A Bellingham, Dr G Mufti I spent three months as PRHO to the Department of Thoracic Medicine and the remaining

three months in the Department of Haematological Medicine. This was a busy job with an average medical take of 20 patients per day.

2. February 1991 to July 1991 - House Surgeon Firm I and Cardiothoracic Surgery, Kings' College Hospital, London SE5. Cardiothoracic Consultants: Mr J Desai and Mr A T Forsyth. General Surgical Consultants: Mr H Berry and Mr J Dawson. I spent the first three months of this appointment in General Surgery and the second three

months in Cardiothoracic Surgery. It was during this job that I developed a special interest in Cardiothoracic Surgery.

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B. Basic Surgical Training (SHO) Posts (3 years)

1. August 1991 to July 1992 - SHO Accident and Emergency & Anatomy Demonstrator Kings' College Hospital, London SE5. Head of Anatomy: Professor K Webster. Consultant A&E: Dr E Glucksman. This year was spent working part time in the busiest A & E Department in London and

part time as an Anatomy demonstrator at the attached University. This had the advantage over two separate six month jobs in that I spent a full academic year teaching anatomy, enabling me to demonstrate the entire human body. During this appointment I gained valuable experience in the management of trauma.

2. August 1992 to January 1993 - SHO Cardiothoracic Surgery Hammersmith Hospital, London W12. Consultants: Professor K Taylor, Mr Bruce Keogh and Mr Peter Smith. During this appointment I was responsible for covering the patients on the ward and the

ITU. There was no shortage of operative exposure and at the end of my six months I was able to harvest a long saphenous vein and was regularly the first assistant at coronary artery bypass grafting. I also gained experience in assisting at valve surgery and a weekly thoracic list. I was allowed to perform median sternotomy and close chests under supervision.

3. February 1993 to July 1993 - SHO Orthopaedic Surgery Whipps Cross Hospital, London E11 1NR. Consultant: Mr Tom Mc Auliffe. I enjoyed working in this busy Orthopaedic center as the teaching was excellent. I had, by

the end of the job gained valuable experience with an arthroscope and had good exposure to current methods of external and internal fixation.

4. August 1993 to July 1994 - SHO General Surgery St Helier Hospital, Carshalton, Surrey, SM5 1AA. Consultants: Mr N J Bett, Mr A Nash, Mr J Edwards and Mr A Chilvers. In undertaking this appointment, I completed the requirements for the clinical part of the

FRCS (Eng) exam. This job exposed me to busy elective major and day case lists and also given me good emergency surgical experience as the hospital has a busy A & E Department. By the end of this job I was performing my own day case lists and being supervised in major surgery. I was able to gain experience in laparoscopic procedures, having assisted at laparoscopic cholecystectomies, laparoscopic Nissen fundoplications, laparoscopic hernia repairs and laparoscopically assisted hemicolectomies. I have performed 3 laparoscopic cholecystectomies. It was during this post that I passed the clinical section of the FRCS (Eng) examination.

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C. Post Fellowship, Pre Rotation Cardiothoracic Experience (17 months)

1. August 1994 to December 1994 - SHO Cardiothoracic Surgery St Mary's Hospital, London W2. Consultants: Mr R Sapsford, Mr B Glenville, and Mr R Stanbridge. This six month position enabled me to build on the experience I had previously gained as

Cardiothoracic SHO at the Hammersmith Hospital. My ward duties included taking ward rounds, admitting patients and being responsible for their post-operative care. Operatively, in addition to harvesting the long saphenous and arm vein, I began routinely opening and closing chests. I gained some experience in aortic cannulation and preparation of the internal mammary artery for grafting.

2. January 1995 to December 1995 - Locum Registrar Cardiothoracic Surgery King's College Hospital, London SE5 9RS. Consultants: Mr J B Desai, Mr M Marrinan and Mr A T Forsyth This post gave me good exposure to adult cardiac and thoracic surgery. I performed

thirty eight cases of coronary artery bypass grafting, seven of which were with SHO assistance only. I also performed three aortic valve replacements. I routinely prepared and cannulated patients undergoing mitral valve surgery. I performed three right lower lobectomies and also a left upper lobectomy. I was also exposed to video assisted thoracoscopic surgery and able to build on this experience at the Ethicon VATS course I attended in Hamburg in September 1995.

My other duties included covering intensive care, taking ward rounds and being able to

admit patients. I attended a weekly outpatient clinic, where I saw patients with follow up appointments. I sometimes saw new patients as well. I presented a monthly audit and a paper review at the weekly journal club.

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D. Higher Surgical Training (Cardiothoracic Trainee, West London Rotation) (6.5 years including 1 year of full time research)

1. January 1996 to February 1997 - SpR in Cardiothoracic Surgery Harefield Hospital, Harefield, Middlesex, UB9 6JH 01 January 1996 to 30 June 1996 Consultants: Mr E R Townsend, Mr S W Fountain The first 6 months of this rotation focussed on Thoracic Surgery. I attended daily

operating lists and was responsible for the pre and post op management of the patients on the wards. On-call duties were centered around the busy intensive care unit.

01 July 1996 to 28th February 1997 Consultants: Professor Sir Magdi Yacoub, Mr A Khagani, Mr M Haw I then moved into the department of Cardiac Surgery where I gained further experience in

Coronary artery bypass grafting and began operating independently. I also had exposure to the use of homografts and stentless valves in cardiac surgery. I learned to perform organ retrieval for transplantation during this time.

2. March 1997 to February 1998 - SpR in Cardiothoracic Surgery St George's Hospital, Tooting, London SW17 0QT Consultants: Professor T Treasure, Mr John Smith, Mr A Murday, Mr J Gaer and Mr RE Sayer (Thoracic) During this job I was able to consolidate the basic cardiac surgical work, the thoracic

surgical experience and the transplant experience I had gained at Harefield Hospital. 3. March 1998 to October 1998 - SpR in Cardiothoracic Surgery The Hammersmith Hospital, Du Cane Road, London W12 0HS Consultants: Professor K Taylor, Mr P Smith and Mr C Ratnatunga. This year was interrupted to undertake my year of research at the Rayne Institute, Kings

College London. (see below).

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4. November 1998 to October 1999 - Research Registrar St George's Hospital, Tooting, London SW17 0QT Supervisor: Professor T Treasure My research was carried out with a grant from the trustees of St George's Hospital,

London. The work was actually performed at the Rayne Institute, King's College London in the Department of Molecular Medicine. Professor Farzin Farzaneh is head of Department and Dr Bernard Souberbielle is my lab supervisor. My project involved the investigation of gene therapy in the treatment of mesothelioma and lung cancer.

5. November 1999- February 2000 - SpR in Cardiothoracic Surgery The Hammersmith Hospital, Du Cane Road, London W12 0HS Consultants: Prof K Taylor, Mr P Smith, Mr J Anderson and Mr P Punjabi. Having interrupted this year to undertake a year of research, I returned to clinical

cardiothoracic surgery where I was able to continue where I left off. I was allowed to perform more difficult but routine cardiac surgery and my valve experience increased. There was only modest thoracic experience available during this attachment.

6. March 2000 to December 2000 - SpR in Cardiothoracic Surgery The Hammersmith Hospital, Du Cane Road, London W12 0HS Consultants: Prof K Taylor, Mr P Smith, Mr J Anderson and Mr P Punjabi. I was allowed a second clinical year at the Hammersmith, but this time as the senior

specialist registrar. My additional duties involved organising waiting lists, prioritising patients on the waiting lists and those referred for inpatient opinion.

7. January 2001 to December 2001 - SpR in Cardiothoracic Surgery Harefield Hospital , Harefield, Middlesex, UB9 6JH Consultants: Mr E R Townsend, Mr S W Fountain (Thoracic) Consultants: Professor Sir Magdi Yacoub, Mr A Khagani, Mr J Gaer, Mr M Amrani and Professor Gilles Dreyfus. My second clinical year at Harefield allowed me to consolidate my experience in thoracic

surgery under the guidance of Mr S W Fountain and Mr E R Townsend. This unit is well respected on the rotation as, being a dedicated thorac unit, the standard of thoracic training is second to none.

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During the second six months in cardiac surgery I had the privilege of working with Mr Mohammed Amrani and Mr Asghar Khagani. The highlight of this period was that during it I learned to perform both off pump cardiac surgery and also became competent at minimally invasive direct coronary artery bypass surgery. I also worked with Professor Gilles Dreyfus whose experience in mitral valve repair is well recognised.

8. January 2002 to 30th June 2002. Final year SpR in Cardiothoracic Surgery The Heart Hospital, UCL Hospitals Trust, Westmoreland Street, London W1. Consultants: Mr R K Walesby, Mr C W Pattison, Mr P Kallis, Mr M J Hayward and Mr S

K Kolvekar I enjoyed the last six months of my rotation being allowed to tackle difficult clinical cases

including aortic root surgery, redo coronary and valvular surgery and resection of stage IIIa lung cancer. The trust then offered me the position of Locum Consultant in Cardiothoracic Surgery with effect from 01 July 2002.

9. 01 July 2002 to 31st May 2003. Locum Consultant Cardiothoracic Surgeon The Heart Hospital, UCL Hospitals Trust, Westmoreland Street, London W1G 8PH I now enjoy the experience of working as a consultant, yet having the benefit of working

with senior colleagues with whom I am familiar. They will be to hand for discussion and supporting me with challenging clinical scenarios. I believe that the current clinical climate that we work in requires that we recognize our limitations and are not shy to seek help from more experienced colleagues when appropriate. I continue to be involved in teaching medical students and other junior doctors at our twice weekly meeting. I have also continued to be involved in the administration of the SHO and SpR rotas and ensuring compliance of the unit with the national junior doctors hours requirements.

I have undertaken three audits projects this year. Analysis of the above average death

rates for patients undergoing cardiac surgery in the UCLH Trust during 1999-2001 revealed that small coronary vessels were associated with an increased mortality in low risk patients undergoing coronary artery surgery. This was supported in the second audit for the year 2001-2002. An audit of the deaths for 2002-2003 (part year) showed that poor left ventricular function, diabetes, peripheral vascular disease and renal insufficiency were associated with increased mortality in high risk patients. Our practice has consequently been adjusted and has helped result in a reduction in our units operative mortality from 4.8% (2001-2002) to 2.9% (2002-2003) (8 months) for patients undergoing 1st time coronary artery bypass surgery.

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F. Research Experience

1. November 1998 to October 1999 - Research Registrar St George's Hospital, Tooting, London SW17 0QT. Laboratory Supervisor: Dr Bernard Souberbielle, Educational Supervisor: Professor T Treasure. My research was carried out with a grant from the trustees of St George's Hospital,

London. The work was performed at the Rayne Institute, King's College London in the Department of Molecular Medicine. Professor Ferzin Farzaneh is head of Department and Dr Bernard Souberbielle is my lab supervisor.

The project involved the investigation of the effect of combining Herpes Simplex Virus

Thymidine Kinase (HSV-tk) suicide gene therapy with established chemotherapy regimens in the treatment of malignant mesothelioma and lung cancer.

This thesis was completed, bound and submitted to the University of London for

consideration for the award of the MS degree on the 11th October 2002. The degree of MS (London) was conferred on 31st January 2005.

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A copy of the abstract summarising my research is shown below THE EFFECT OF COMBINING GENE THERAPY AND CHEMOTHERAPY ON MALIGNANT MESOTHELIOMA. Objective. To investigate the effect of combining allogeneic suicide gene therapy with traditional chemotherapy in the treatment of malignant mesothelioma. Methods. a) in vitro: Three human mesothelioma cell lines were treated with allogeneic Herpes Simplex Virus Thymidine Kinase (HSV-tk) gene therapy and Gancyclovir. The same cell lines were treated with Mitomycin, Vinblastine and Cisplatin. Expression of p53, p21 (WAF-1), cyclin D1 and retinoblastoma proteins were assessed by western blotting. Apoptosis and cell death were assessed by trypan blue exclusion, Annexin V expression and propidium iodide exclusion. Survival was assessed by MTT assay. b) in vivo: Mesothelioma was induced in the peritoneal cavity of 55 mice. These were treated with gene therapy, chemotherapy and a combination of the two modalities. The effects were assessed by post mortem study at 9 days. Results. Gene therapy of mesothelioma cells resulted in a rapid non sustained induction of cell cycle proteins compared to a more gradual but sustained (72 hour) response to chemotherapy. Gene therapy was more effective at killing human mesothelioma cells than chemotherapy (p less than 0.02). Combining the two therapies resulted in synergistic killing of cells in vitro. Gene therapy was more effective reducing mesothelioma tumour load than chemotherapy (p less than 0.05). Combining chemotherapy with gene therapy however resulted in a reduction of the efficacy of gene therapy. Conclusions. Whilst gene therapy is potentially a promising modality of anti-tumour therapy, its dependence on a vigorous host immunological anti-tumour response may prohibit its concurrent use with established chemotherapeutic regimens. This does not preclude sequential treatment by the two modalities, the effect of which is likely to be potent because the treatments induces cell death by different mechanisms.

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6. Trainee Operative Experience a. Non Cardiothoracic Orthopaedic Surgery Assisted Performed Arthroscopy of knee 74 12 Dynamic Hip screw 18 17 Austin Moore hemi arthroplasty 13 13 Thompson hemi arthroplasty 02 01 Exeter total hip replacement 57 01 Total knee replacement 48 01 Femoral intermedullary nailing 06 Tibial intermedullary nailing 05 Humeral intermedullary nailing 02 General Surgery Assisted Performed HSV ligations 12 74 Lichtenstein hernia repair 10 38 Right hemicolectomy 03 02 Hemi thyroidectomy 14 01 Mastectomy and level 1 axillary dissection 09 02 Laparoscopic cholecystectomy 27 03 Femoral embolectomy 06 02

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6. Operative Experience (cont) b. Cardiothoracic Surgery (as a trainee) Assisted Performed Cardiac surgery Coronary artery bypass graft Using cardio pulmonary bypass -- 730 Off - pump CABG 25 28 Redo CABG -- 14 MIDCAB 6 5 Aortic valve replacement Mechanical/ Stented 59 81 Homograft 12 2 Stentless porcine 14 1 Mitral valve repair 18 9 Mitral valve replacement 58 23 Median sternotomy for redo operation 53 Transplantation Retrievals for transplant Heart 38 Heart Lung 14 Transplantation Heart 16 1 Lungs (single) 09 - Heart Lung 08 - Perfusion: Cardiopulmonary Bypass Assisted Performed 02 02 I spent a week in the Department of Clinical Perfusion at Kings' College Hospital where I was instructed in running a Cardiopulmonary Bypass Machine. I learnt about the construction and disassembly of the pump and concluded with performing two supervised cases.

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Thoracic surgery (as a trainee) Assisted Performed Mediastinoscopy 125 Tracheostomy 55 Rigid bronchoscopy 130 Lobectomy 90 Pneumonectomy 20 Oesophagectomy 51 3 Trans Thoracic Hiatus Hernia 12 - Video assisted thoracoscopy (as a trainee) Performed 261 This involves thoracoscopy for lung biopsy, pleurodesis, pleurectomy and excision of pericardial cyst. I have also performed VATS for assessing resectability of lung carcinoma and in the treatment of empyema.

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8. Publications and Presentations i) Publications

1. A 45 degree two stage venous cannula: advantages over standard two stage venous cannulation. Lawrence DR, Desai JB. Ann Thorac Surg 1997; 63: 253-4

2. Thoracoscopic Debridement of Empyema Thoracis. Lawrence DR, Ohri SK,

Moxon RE, Townsend ER, Fountain SW. Ann Thorac Surg 1997;64:1448-50

3. Homograft as a conduit for Superior Vena Cava Syndrome. Ohri SK, Lawrence DR, Townsend ER. Ann Thorac Surg 1997;64:531-533.

4. The effects of Cardiopulmonary Bypass Perfusion Protocols upon Gut Tissue

Oxygenation and Blood Flow. Ohri SK, Bowles CW, Mathie R, Lawrence DR, Keogh BE, Taylor KM. Ann Thorac Surg 1997;64:163-70.

5. Iatrogenic Oesophageal Perforations: A Clinical Review. Lawrence DR, Ohri S,

Moxon R, Townsend E, Fountain SW. Ann R Coll Surg Engl 1998;80:115-118

6. Primary Oesophageal Repair for Boerhaave's syndrome. Lawrence DR, Ohri S, Moxon R, Townsend E, Fountain SW. Ann Thorac Surg 1999;67:818-820

7. Forearm fasciotomy post cardiac surgery. Poullis M, Lawrence DR, Ratnatunga

C. European Journal of Cardiothoracic Surgery 1999;16:580-581

8. The effect of combining Gene Therapy and Chemotherapy on mesothelioma cell lines. Lawrence DR, Zweri J, Farzeneh F and Souberbielle B.British Journal of Cancer 1999;80 (2):23-24

9. The Parsonnet Score is a good predictor of post-operative complications and duration of intensive care unit stay. Lawrence DR, Valencia O, Smith EEJ, Murday A, Treasure T. Heart 2000;83:429-432

10. Indications for cardiopulmonary bypass for non cardiac operations. Nair KS, Lawrence DR, Punjabi PP, Taylor KM. Perfusion 2002;17(3):161-166.

11. An unusual cause of mixed mitral valve disease. Nair KS, Lawrence DR, Smith P. Heart 2002;88(6):560-561

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12. Thesis on the use of suicide gene therapy and chemotherapy on malignant mesothelioma. Lawrence DR. MS (Lond) with the University of London, 2005

13. Unique type of isolated cardiac valvular amyloidosis. Iqbal S, Reehana S,

Lawrence D. Journal of Cardiothoracic Surgery 2006, 1:38

14. Are Coronary Angiograms of value in predicting mortality following coronary artery bypass surgery. Lawrence D, Somaskanthan R, Barnard M, Keogh B. Ann R Coll Surg Eng 2009;91:330-335.

15. Remote Ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold blood cardioplegia:a randomised controlled trial. Venugopal V, Hausenloy DJ, Ludman A, Di Salvo C Mr, Kolvekar S, Yap J, Lawrence D, Bognolo G, Yellon DM. Heart 2009Oct;95(19):1553-5.

16. Thoracic empyema: current opinions in medical and surgical management.Lee SF, Lawrence D, Booth H, Morris-Jones S, Macrae B, Zumla A.Curr Opin Pulm Med. 2010 May;16(3):194-200.

17. Failure to Recapture Cardioprotection with High dose atorvastatin in Coronary

Artery Bypass Surgery: A randomized controlled trail. LudmannAJ, Hausenloy D, Babu G, Haselton J, Venugopal V, Boston-Griffiths E, Yap J, Lawrence D, Hayward M, kolvekar S, Bognolo G, Rees P, Yellon D.Basic Research Cardiolol 2011:DOI10.1007/s00395-011-0209-5.

18. Beyond late gadolinium enhancement: the role of diffuse myocardial fibrosis in

severe aortic stenosis – an Equilibrium Contrast CMR study Andrew S. Flett, Dan Sado, Giovanni Quarta, Sanjay Banypersad, DerekHausenloy, Denis Pellerin, David Lawrence, Christopher McGregor, Perry M. Elliott, Andrew M Taylor, James C. JournCardiovasMagRes 2012:13(1)O39

19. Outcomes from Surgical Management of pleural infections: 12-year experience

from a tertiary Cardiothoracic Centre: DJB Marks1,2*, M Fisk, CY Koo, D Lawrence, RF Miller, A Zumla; BTS 2010 dci:101136/thx2010,15097918. PLOSOne 2012;7:30074-8

20. Pulmonary mass in a 19 year old male. Laura-Jane E Smith1, Sam Janes2, Irfan

Kayani3 Mary Falzon4, David Lawrence5, Neal Navani2. Thorax 2011:doi:10.1136/thoraxjnl-2011-200732

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21. Left atrial and right ventricular myxoma: An uncommon presentation of a rare tumour.

Diaz, A., di Salvo, C., Lawrence, D., Hayward, M. Interactive Cardiovascular and

Thoracic Surgery. volume 12, issue 4, year 2011, pp. 622 - 623

22. Endobronchial Ultrasound–guided Transbronchial Needle Aspiration Prevents Mediastinoscopies in theDiagnosis of Isolated Mediastinal Lymphadenopathy. A Prospective Trial.Neal Navani1,2, David R. Lawrence3, Shyam Kolvekar3, Martin Hayward3, Dorcas McAsey3,Gabrijela Kocjan4, Mary Falzon4, Arrigo Capitanio4, Penny Shaw5, Stephen Morris6,Rumana Z. Omar7, and Sam M. Janes1,2; on behalf of the REMEDY Trial Investigators. Am J Respir Crit Care Med Vol 186, Iss. 3, pp 255–260, Aug 1, 2012

23. Measurement of Myocardial Extracellular Volume Fraction by Using

Equilibrium Contrast-enhanced CT: Validation against Histologic Findings. Steve Bandula, MA, MB BChir, Steven K. White, BSc, MBChB, Andrew S. Flett, MD, David Lawrence,, Francesca Pugliese, PhD, Michael T. Ashworth, MD, Shonit Punwani, PhD, Stuart A. Taylor, MD and James C. Moon, MD. http://radiology.rsna.org/content/early/2013/07/17/radiol.13130130.abstract

24. Massive pulmonary carcinoid tumor deemed inoperable until 68Gallium Dotatate

Positron Emission Tomography/Magnetic Resonance Imaging. Katherine Ordidge James Brown, Laura Succony, Georgia Hardavella, David Lawrence, Francesco Fraioli, Ashley Groves.

25. Primary mucoepidermoid carcinoma of the thymus presenting with myasthenia gravis.

Woo WL,Panagiotopoulos N, Gvinianidze L, Proctor I, Lawrence D. J Thorac Dis. 2014 Oct;6(10):E223-5.doi: 10.3978/j.issn.2072-1439.2014.09.19.

26. The challenging management of lung choriocarcinoma. Gvinianidze L, Panagiotopoulos

N, Woo.WL, Borg E, Lawrence D. J Thorac Dis. 2014 Oct;6(10):E220-2. doi: 10.3978/j.issn 2072-1439.2014.09.18.

27. The challenging management of hepatopulmonary fistulas. Panagiotopoulos N,

Kontoravdis N, Lawrence D. J Thorac Dis. 2014 Sep;6(9):1336-9. doi: 10.3978/j.issn.2072-1439.2014.07.19. Review.

28. Aetiology and Management of Spontaneous Haemothorax. Davide Patrini, Nikolaos

Panagiotopoulos, Jonathan Pararajasingham, Lasha Gvinianidze MD, David Lawrence. Accepted for publication Journal of Thoracic Disease.

29. Woo WL, Panagiotopoulos N, Gvinianidze L, Fhadil S, Borg E, Falzon M, Lawrence

D. Primary synovial sarcoma of the lung: can haemothorax be the first manifestation? J Thorac Dis 2014;6(12):E249-E251. doi: 10.3978/j.issn.2072-1439.2014.11.01.

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30. A novel technique for the management of recurrent pericardial effusions. Panagiotopoulos N, Lawrence D. Accepted for publication Journal of Cardiothoracic Surgery. Under review

31. Inflammatory Myofibroblastic Tumor of the lung: a reactive lesion or a true neoplasm?

Panagiotopoulos N, Gvinianidze L, Borg E, Lawrence D. Journal of Thoracic Oncology.

32. Diagnosis and management of pulmonary blastoma. Jonathan Pararajasingham,

Nikolaos Panagiotopoulos, Davide Patrini1, Elaine Borg, David Lawrence. Journal of Thoracic Disease.

33. Spatial and temporal diversity in genomic instability processes define early stage lung

cancer evolution Elza de Bruin1,*, Nicholas McGranahan2,*, Richard Mitter2,*, Max

Salm2,*, David Wedge3,*, Lucy Yates3,§, Mariam Jamal-Hanjani1,§, Nirupa Murugaesu1,

Seema Shafi1, Marco Gerlinger2,#, Andrew Rowan2, Stuart Horswell2, Ignacio Varela4,

David Lawrence5, Mary Falzon5, Arrigo Capitanio5, Timothy Harkins?, Clarence Lee6,

Warren Tom6, Chaitali Parikh6, Sharmin Begum2, Benjamin Phillimore2, Zoltan

Szallasi7, Nik Matthews2, Aengus Stewart2, Peter Campbell3, Charles Swanton1,2.

1University College London Cancer Institute, UK, 2 Cancer Research UK London

Research Institute, UK, 3Wellcome Trust Sanger Institute, UK, 4Instituto de

Biomedicina Y Biotecnologia de Cantabria, Spain, 5University College London

Hospitals, UK, 6 ThermoFisher Scientific, CA, USA, 7 Technical University of

Denmark, Denmark. Accepted by Science

34. Dacron Patch Bronchoplasty For Mucoepidermoid Carcinoma. J Nandi, N

Panagiotopoulos, J Felderhoff,, J George, M Hayward, D Lawrence. In progress.

35. Inflammatory Myofibroblastic Tumor of the lung: a reactive lesion or a true neoplasm? Panagiotopoulos N, Gvinianidze L, Borg E, Lawrence D. Journal of Thoracic Oncology.

36. Diagnosis and management of pulmonary blastoma. Jonathan Pararajasingham, Nikolaos.Panagiotopoulos, Davide Patrini1, Elaine Borg, David Lawrence. Journal of Thoracic Disease

37. Hepatopulmonary Fistula - A complication Of Hydatid Disease, Davide Patrini, Mohamed A Gulamhussein; Jonathan Pararajasingham, MBBS; Benjamin Adams, MD; David R Lawrence, FRCS; Nikolaos Panagiotopoulos, MD International Journal of Infectous Diseases Submitte Manuscript Number: IJID-D-15-00092

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38. A novel technique for the management of reccurent malignant pericardial effusions Updated scheduling information, final category and publication numbers will be available shortly on the ELCC 2015 website via http://www.esmo.org/Conferences/ELCC-2015-Lung-Cancer/Programme

39. EJCTS/2015/440891 Is brachytherapy effective for local recurrence control

in sublobar resections for non small cell lung cancer?, TOC Category: Thoracic oncologic, Best Evidence Topic (ICVTS) (received: July 21, 2015)

40. Is brachytherapy effective for local recurrence control in sublobar resections for non-

small-cell lung cancer? Patrini D, Lawrence D, Adams B, Panagiotopoulos N. Interact Cardiovasc Thorac Surg. 2015 Nov; 21(5):677-81.

41. 2. The application of Plasmajet Surgical System for the Thoracic Empyema

decortication- A novel technique. Panagiotopoulos N, Patrini D, Shukla R, Hayward M, Lawrence D. Published on CTSnet (http://ctsnet.org).

42. 3. Inflammatory Myofibroblastic Tumour of the lung – A reactive lesion or a true

neoplasm? Panagiotopoulos N, Patrini D, Gvinianidze L, Woo Wl, Borg E, Lawrence D. J Thorac Dis 2015.

43. 4. Etiology and management of spontaneous haemothorax. Patrini D, Panagiotopoulos

N, Pararajasingham J, Iqbal Y, Gvinianidze L, Lawrence D. J Thorac Dis 2015 Mar;7(3):520-6

44. 5. Iatrogenic tracheal rupture- the role of a thoracic surgeon. Panagiotopoulos N,

Gulamhussein M, Patrini D, Shukla R, Lees M, Hayward M, Kolvekar S, Lawrence D. Int J Respir Pulm Med 2015, 2:4.ISSN: 2378-3531.

45. 6. Hepatopulmonary Fistula: a life threatening complication of hydatid disease.

Gulamhussein MA, Patrini D, Pararajasingham J, Adams B, Shukla R, Velissaris D, Lawrence D, Panagiotopoulos N. J Cardiothorac Surg. 2015 Jul 29;10(1):103.

46. 7. A novel sutureless technique for the repair of coronary sinus injuries.

Panagiotopoulos N, Patrini D, Adams B, Lawrence D, Roberts N. J Thorac Dis. 2015 Dec;7(12):2359-61. doi: 10.3978/j.issn.2072-1439.2015.12.43.

47. 8. 3rd Generation EGFR TKIs- A Major Breakthrough for NSCLC Treatment.

Panagiotopoulos N, Lawrence D. J. of Respiratory Res.2015 November 1(1):49-60. ISSN 2409-0579.

48. 9. Key Features in the Management of Pulmonary Carcinosarcoma. Panagiotopoulos N,

Patrini D, Adams B, Pararajasingham J, Shukla R, Borg E, Hayward M, Lawrence D. Case Rep Pulmonol. 2016;2016:2020146.

49. 10. Sclerosing hemangioma of the lung showing strong FDG avidity on PET scan: Case

report and review of the current literature. Patrini D, Shukla R, Lawrence D, Borg E, Hayward M, Panagiotopoulos N. Respiratory Medicine Case Reports, Vol. 17, p20–23.

50. 11. The Potential Malignancy of a Solitary Fibrous Tumour of the Lung. Shukla R,

Patrini D, Borg E, Lawrence D, Hayward M, Panagiotopoulos N. Case Rep Pathol.

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2015;2015:209490. 51. IgG4 related lung disease extending to the thoracic vertebrae, get info

ii) Presentations

1. A not so Septic Shock. A presentation to the General Grand Round of the Hammersmith Hospital on a case of a dissecting aortic aneurysm. This audiovisual presentation included a discussion on the current methods of imaging the thoracic aorta and the options available in the management of such a case. December 1992.

2. The use of Bilateral ITA for CABG gives good early results in patients aged 70 years

and over. Lawrence DR, Desai JB, Marrinan M, Forsyth A.Presented at the Annual Meeting of the Society of Cardiothoracic Surgeons of Great Britain and Ireland at Llandudno, 20-22 March 1996.

3. Thoracoscopic Debridement of Empyema Thoracis.Lawrence DR, Ohri SK, Moxon

RE, Townsend ER, Fountain SW.Presented at the 10th Annual Meeting of the European Association for Cardiothoracic Surgery in Prauge in September 1996.

4. Primary oesophageal repair for Boerhaave's syndrome.Lawrence DR, Ohri S, Moxon R,

Townsend E, Fountain S. W. Presented at the 11th Annual Meeting of the European Association for Cardiothoracic Surgery in Copenhagen, 27th September 1997 to 1st October 1997.

5. The Parsonnet Score is a good predictor of post-operative complications and duration of

intensive care unit stay. Lawrence DR, Valencia O, Poloniecki J, Smith EEJ.Presented at the Annual Meeting of the Society of Cardiothoracic Surgeons of Great Britain and Ireland at Edinburgh, March 1998.

6. The effect of combining Gene Therapy and Chemotherapy on mesothelioma cell lines

Lawrence DR, Zweri J, Farzeneh F and Souberbielle B. Presented at the British Cancer Research Meeting, Edinburgh, 13th July 1999.

7. The effect of combining Gene Therapy and Chemotherapy on human mesothelioma, in

vivo and ex vivo experience Lawrence DR, Zweri J, Farzeneh F and Souberbielle

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B.Presented at the 8th European Conference on General Thoracic Surgery. European Association of Thoracic Surgeons Meeting, London, United Kingdom, 1-3 November 2000.

8. A review of the low Parsonnet deaths following coronary artery surgery in our unit. A

review of 1300 cases (1999-2001). An audit presentation following the release of the Doctor Foster report. Lawrence DR. Presented to the Audit meeting of the Heart Hospital, April 2002.

9. Why do patients with low Parsonnet Scores sometimes die following Coronary artery

bypass surgery Lawrence DR. An audit presentation to the Board of University College Hospitals NHS Trust including members from the Department of Health. UCH Audit Day, 11th July 2002.

10. A review of the mortality following cardiac surgery in our unit (2002 2003).

Identification of risk factors for surgery and preparation of protocols for the optimisation of patients prior to undergoing cardiac surgery.Lawrence DR, Smith A. 11th December 2002.

11. Are coronary angiograms of value in the risk stratification of patients undergoing

coronary artery bypass surgery? Lawrence DR, Somaskanthan R, Barnard MJ, Curtis M, Keogh BE. Presented at the 56th meeting of the European Society for Cardio-Vascular Surgery, Venice Italy 19th May 2007. C11-5.

12. Outcomes from Surgical Management of pleural infections: 12-year experience from a

tertiary Cardiothoracic Centre: DJB Marks1,2*, M Fisk, CY Koo, D Lawrence, RF Miller, A Zumla; BTS 2010 dci:101136/thx2010,15097918.

13. Inflammatory Myofibroblastic Tumour Of The Lung - A Reactive Lesion Or A True

Neoplasm? . Lasha Gvinianidze, Nikolaos Panagiotopoulos, Wen Ling Woo, David Lawrence.

14. A novel technique for the management of reccurent malignant pericardial

effusionsUpdated scheduling information, final category and publication numbers will be available shortly on the ELCC 2015 website via http://www.esmo.org/Conferences/ELCC-2015-Lung-Cancer/Programme

15. The application of Argon Plasma Energy for thoracic empyema decortication: a novel

technique. Patrini D, Hayward M, Shukla R, Lawrence D, Panagiotopoulos N. 24th European Conference on General Thoracic Surgery, Naples, 29 May- 1 June 2016.

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16. The potential malignancy of a solitary fibrous of the pleura. Patrini D, Hayward M,

Ekeowa U, Russell P, Lawrence D, Panagiotopoulos N. American Thoracic Society International Conference, San Francisco, 13-18 May 2016.

17. Pulmonary alveolar microlithiasis. Garg S, Panagiotopoulos N, Lawrence D, Hayward

M, Kolvekar S. American Thoracic Society International Conference, San Francisco, 13-18 May 2016.

18. Lobectomy for non-small cell lung cancer in octogenarians. A 7-year single centre

experience. Panagiotopoulos N, Patrini D, De Cabanyes S, Hayward M. European Lung Cancer Conference (ELCC). Geneva, 13-16 April 2016.

19. A novel technique for thoracic empyema decortication. Panagiotopoulos N, Shukla R,

Patrini D, Hayward M, Lawrence D. 3rd International Joint Meeting on Thoracic Surgery, Barcelona, 18-20 November 2015.

20. Sclerosing pneumocytoma - An unexpected benign lesion. De Cabanyes S, Shukla R,

Patrini D, Hayward M, Lawrence D, Panagiotopoulos N. 3rd International Joint Meeting on Thoracic Surgery, Barcelona, 18-20 November 2015.

21. Pulmonary lymphangioleiomyomatosis – The role of a thoracic surgeon. Petko M,

Hayward M, Lawrence D, Panagiotopoulos N. 3rd International Joint Meeting on Thoracic Surgery, Barcelona, 18-20 November 2015.

22. The Application Of The Plasmajet Surgical System (PSS) For Thoracic Empyema

Decortication – A Novel Technique. Shukla R, Patrini D, Hayward M, Lawrence M, Panagiotopoulos N. ANZSCTS Annual Scientific Meeting 2015, Adelaide, 15- 18 November 2015.

23. Key features in the management of pulmonary carcinosarcoma. Adams B, Patrini D,

Pararajasingham J, Lawrence D, Panagiotopoulos N. 23rd Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

24. A sutureless technique for the repair of coronary sinus injuries. Panagiotopoulos N,

Patrini D, Adams B, Roberts N. 23rd Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

25. Iatrogenic tracheal rupture: An intricate diagnosis. Panagiotopoulos N , Patrini D ,

Witzke ., Ashley E, Lees M , Kolvekar S. 23rd Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

26. Pulmonary Blastoma, A rare primary lung malignancy. Pararajasingham J, Patrini D,

Adams B, Gulamhussein M, Lawrence D, Panagiotopoulos N. 23rd Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, Hong Kong, 11-14 May 2015.

27. A novel technique for the management of recurrent malignant pericardial effusions.

Panagiotopoulos N, Patrini D, Adams B, Lawrence D. European Lung Cancer Conference ELCC, Geneva, 15-18 April 2015.

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28. Hepatopulmonary Fistula – A life threatening complication of hydatic disease. Gulamhussein M, Patrini D, Adams B, Pararagasigham J, Lawrence D, Panagiotopoulos N. European Society of Thoracic Imaging Meeting, Barcelona, Spain 4-6 June 2015.

9. Courses attended

November 1991 Sloame Course for primary FRCS. This two month evening

course was an essential part of success at the primary FRCS examination.

May 1994 St Thomas' Hospital Course for part B FRCS. The three week

full time course consolidated the knowledge I had acquired over the past three years and helped me to be successful at the examination in June 1994.

May 1994 Rowley Bristow Orthopaedic Course. This two weekend course

was run by Professor Appley and his colleagues at St Peters' Hospital, Chertsey. It consisted of lectures, practical demonstrations and assessments.

November 1994 Advanced trauma and life support course at Kings' College

Hospital. After completing this course I was invited return to undertake the ATLS instructor course.

May 1995 Cardiac Surgery '95. This course was run by Professor Sir

Magdi Yacoub and provided a current update of the basic sciences (including molecular biology) and clinical aspects of cardiothoracic surgery.

September 1995 Ethicon Video Assisted Thoracoscopy Course at the European

Surgical Institute, Hamburg. This covered pleurodesis, pleurectomy, lung biopsy, lobectomy, pneumonectomy, PDA ligation and division of vascular rings.

September 1996 International Paediatric Conference at GOS Hospital October 1998 Applied Basic Science for Cardiothoracic Surgeons

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Royal College of Surgeons of England. Course covenors Professor Tom Treasure and Mr Jules Dussek.

March 1999 Aortic Valve, Homograft and Aortic Root replacement

workshop at St George's Hospital, as part of the SpR training day. May 1999 Mitral valve workshop at the Hammersmith Hospital, as part of

the SpR training day. July 1999 International Cancer Gene Therapy Conference 1999 at the

Hammersmith Hospital, 8-9 July 1999 July 1999 British Cancer Research Meeting 1999. Edinburgh Conference

Centre, Herriott Watt University, Edinburgh, 12-14 July 1999 November 2000 Course in techniques of mitral valve repair. Hospital Cardiologie, Lyon, France. Professor J Obadia. April 2001 Revision Course in Paediatric Cardiac Surgery Gt Ormond Street Hospital Professor R Anderson and Mt V Tsang. September 2001 Birmingham Heartlands Course in Cardiothoracic Surgery.

Heartlands Hospital, Birmingham. Mr R Rajesh and Tim Graham. December 2001 Clinical Management Course for Specialist Registrars. Royal

College of Surgeons. 17th to 19th November 2001. November 2002 TOE Course, University College Hospitals NHS Trust. Dr Sue Wright and Dr Bruce Martin 4th to 7th November 2002. April 2003 Cardiothoracic Training the Trainers. The Royal College of

Surgeons of England. 24-25th April 2003. August 2003 Recruitment and Selection Procedure for UCLH NHS Trust A 2 day course on the backgroung and Trust Procedures. UCLH

Trust Headquarters. May 2004 Perimount Magna Meeting. Sponsored by Edwards

Lifesceinces, this study was a forum for cardiothoracic surgeons with an interest in this valve. Gleneagles, Scotland.

October 2004 Curative Approaches to Lung Cancer. The Belfrey, Wishaw,

Birmingham. RCP 4 Credits. 7th October 2004

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December 2004 Heart Valve Club Meeting. This is the new revamped “Club Mitrale”. A forum for Consultants with an interest in Mitral repair. Chaired by Alain Carpentier, 6th – 8th Dec 2004.

May 2005 Perimount Magna – A UK Review. I spoke on this course as I

am experienced with this valve, explaining the techniques of implantation to UK Cardiothoracic Surgeons. Gleneagles Scotland.

March 2006 Heart to Heart Series, first forum on aortic stenosis. Sevilla, Spain. A forum for consultants with an interest in Aortic Valve disease. 30th March to 1st April 2006

May 2007 87th Meeting of the American Association for Thoracic

Surgeons. Washington DC, USA. May 5th to May 9th 2007 May 2007 Contemporary Approaches and controversial Directions in the

Surgical treatment of Atrial Fibrillation. Washington DC, USA. 6th May 2007.

May 2007 56th meeting of the European Society for Cardio-Vascular

Surgery, Venice, Italy 20th May 2007. June 2007 Master of Mitral Valve introductory course. Hospital

Universitari Clinic, Barcelona, Spain. June 4th to 6th 2007 September 2007 ‘An update on Techniques and Outcomes of Surgical

treatment of Atrial fibrillation’. Barcelona, Spain. 2nd to 4th September 2007.

January 2008 London trainers and Educational Supervisors Day The Royal College of Surgeons. Chairman Nigel Stansfield. 24th

January 2008 September 2008 Towards Safer Repeat Cardiac and Thoracic Surgery Friday September 19th 2008 @ University College london December 2008 Perioperative echocardiography and Mitral Valve Repair

Workshop. Glenfield Hospital 3rd and 4th December 2008. June 2009 8th Emergencies in Cardiology Course for Consultants 25th and 26th June 2009. Chair Dr J Mc Ewan. September 2009 Voyage into Innovation. Course by Sorin for education into the

manufacture of Biological prostheses. 23rd to 24th September 2009 Saluggia, Italy.

November 2009 TAIP Course University College Londons Hospitals NHS Trust. 4th November

2009. November 2009 Training the Trainers Completion

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University College Londons Hospitals NHS Trust. 4th November 2009.

November 2009 Educational Supervisors Course. University College Londons Hospitals NHS Trust. 26th November

2009. January 2010 WHO Surgical Safety Checklist Programme. Simulation

Training Day. University College Londons Hospitals NHS Trust. 26th January 2010

July 21st 2010 Innovation: Ethicon Biosurgery Innovation Lab, European

Surgery institute, Hamburg- Norderstedt, Germany. 1st Juy 2010 Aug/Sep 2010 Emergency Cardiology Course for Consultants x 2 September 2010 National Advanced Communication Skills Training (ACST) Ashford Hospital, 27th to 29th September 2010. October 6th 2010 Innovation (Speaker): Ethicon Biosurgery Innovation Lab,

European Surgery institute, Hamburg- Norderstedt, Germany. Faculty.

October 20th 2010 Innovation (Speaker): Ethicon Biosurgery Innovation Lab,

European Surgery institute, Hamburg- Norderstedt, Germany. Faculty

Nov 2010 East Anglian Society of Thoracic Physicians: EASTP Meeting

Harlow (Faculty) Nov 2010 Colorectal Mets Meeting (Faculty) Nov 2010 Recent Advances in Lung Cancer Management (Faculty):

Royal Society of Medicine Feb 2011 Equality, Diversity and Interview Techniques Training

Course. Royal College of Surgeons, London UK 25th February 2011

May 2011 Peer to Peer Haemostasis Baxter Biosurgery Conference.

Vienna. 13th May 2011 July 2011 GP Meeting Lecture, Royal Society of Medicine September 2011 Medicolegal Expert Witness Training, Healthcare Knowledge

Ltd. London. January 2012 El Khaboury 8th International Advanced Valve Repair

Symposium. Advanced Techniques in Mitral Valve Repair. 16th -17 January 2012 Brussels.

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February 2013 Recent Advances in Medicine and Surgery,The RSM, Delegate and Speaker, RSM, 1 Wimpole Street, London W1.

October 2013 Tracer –X Study Day. 04th Otober 2013. Tracking Non Small

Cell Cancer through Evolution. UCLH. November 2013 UCLH Basic Life Support Refresher Course, 12th November

2013. UCLH February 2014 SCTS Thoracic Forum, 7-8th February 2014. Oxford. September 2014 Mitral Valve Repair (Neochordae Course), 23rd and 24th

September Prof. Gerosa, Padua, Italy. Aug 2014 : 6th Latin American Conference on Lung Cancer 21-23 Aug 2014

Lima,Peru. MUCOEPIDERMOID CARCINOMA OF THE THYMUS AND MYASTHENIA GRAVIS. IS THERE AN ASSOCIATION? Wen Ling Woo, Nikolaos Panagiotopoulos, Lasha Gvinianidze, David Lawrence.

October 2014 VATS Lobectomy Course, Bristol Royal Infirmary, 6th and 7th

October 2014. November 2014 Peri operative Care of Thoracic Surgical Patient ( organising

committee) , 8 November 2014,London. VATS versus open lobectomyand the future of thoracic surgery

December 2014 Cardiac Surgery 2014 : Oxford Deanery Regional Cardiology Teaching

-Oxford Deanery Regional Cardiology Teaching -. Trust Education

Centre, Royal Berkshire Hospital, RG1 5AN.

Feb 2015 SCTS Thoracic Forum, 6-7th February 2015. Hull April 2015 British Nuclear Medicine Conference 2015; Brighton May 2015 Merck Study day (Lecturer) October 2015 Training in France Marseilles re Robot with Cristof Donnely December 2015 Intuitive traininig Strasburgh. 7th to 8th December 2015 February 2016 Thoracic Forum, Southampton October 2016 International VATS Conference, Royal College of Physicians

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10. Examiner for University of London June 2004 University of London, Final MBBS, Examiner, Surgical Short

Station. August 2005 University of London: 3rd year OSCE Examiner June 2006 University of London, Final MBBS, Examiner, Surgical Short

Station. June 2007 University of London, Final MBBS, Examiner, Surgical Short

Station. August 2007 University of London: 3rd year OSCE Examiner 11. Professional Aims and Interests. I have made a career in adult cardiothoracic surgery. I have been privileged to be a member of the West London Cardiothoracic Rotation and received excellent training with good exposure to both adult cardiac and thoracic surgery (Jan 1996 - December 2002). I enjoy the all aspects of adult cardiothoracic surgery and am particularly comfortable with performing coronary artery bypass surgery (both on and off pump) routine aortic and mitral valvular surgery and all aspects of thoracic surgery. I have made a special effort to gain experience in off pump coronary artery surgery and mitral valve repair. My operative mortality for coronary artery surgery, is described on the peer reviewed Healthcare Commission website as “better than expected” when compared to equivalent surgeons across Europe. My commitment to thoracic surgery is demonstrated by choice of the field of my research. I intend to commence a clinical trial in gene therapy of malignant mesothelioma using previously transfected allogeneic cells. Allogeneic suicide gene therapy does not include exposure of the patients to viral vector, which would bypass the justifiable concerns of the consequences of exposure of medical personnel to genetically modified vectors. Molecular biology is a relatively new tool with which progress into the understanding and treatment of disease is being steadily made. I feel that I am now in a position to undertake clinically relevant research that is likely to have an impact on the management of our patients. I enjoy teaching both medical students and junior members of staff and believe that this is an important obligation doctors have. I am aware that it is due to the efforts of my senior colleagues that I am able to operate independently today and this is only repayable by doing the same for junior members of the team. I am familiar with current information technology

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systems and am able to help the department make full use of the wide range of resources to hand. This has been of value in analysing the units cardiac surgical outcomes data

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12. Outside Interests Tennis I have played tennis at inter school and inter club level. I am

currently captain of the David Lloyd Ealing Mens First Team and play Middlesex League and National League Tennis. I have a UK LTA rating of 5.1

Cricket I was a 1st XI player at School and University. I represented

Wallington High School for Boys, King's College London, Kings College Hospital and finally my local club as an opening batsman and fast bowler. As a Registrar at Kings College Hospital, I led the team on a fortnights tour of Barbados, West Indies in August 1995.

Rugby Football Played to under 17 level. Vice captain at under 13 and under 15

year age group. Position: Scrum half. Scuba Diving I am a Professional Association of Diving Instructors (PADI)

certified Open Water recreational SCUBA diver. 12. Referees Professor W McKenna, Medical Director, The Heart Hospital, London W1G 8PH. Tel: 0207 573 8888. Professor Sir Bruce Keogh, Director of Cardiothoracic Surgery, The Heart Hospital, London W1G 8PH. Tel: 0207 573 8888