CURRICULUM VITAE Richard C. Garrad

R.C.Garrad 1

CURRICULUM VITAE

Richard C. Garrad

June 2016

Department of Biomedical Sciences Missouri State University Springfield, MO 65897 Tel- (417) 836 5372 Fax- (417) 836 5588

E-mail- [email protected]

Education 1993 Ph. D. Microbiology Department. Miami University, Oxford Ohio. Dissertation: Molecular Characterization of the Cloned LYS1 Gene of Candida albicans. 1989 M.S. Microbiology Department, Miami University, Oxford Ohio. Thesis: Lysine Biosynthesis in Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. 1982 F.I.M.L.S. Terminal Microbiology degree in Medical Laboratory Sciences, Paddington Polytechnic (now University of Westminster), Paddington, London, United Kingdom.

Professional Experience 2010-Present Professor, Biomedical Sciences Department, Missouri State University, Springfield, MO 2004-10 Associate Professor, Biomedical Sciences Department, Missouri State University, Springfield,

MO 2001-04 Assistant Professor, Biomedical Sciences Department, Southwest Missouri State University,

Springfield, MO 1997-01 Research Assistant Professor, Department of Biochemistry, University of Missouri-Columbia,

Columbia MO. 1993-97 Post-Doctoral Research Associate (In the laboratory of G.A. Weisman). 1989-93 Ph.D. (In the laboratory of J.K. Bhattacharjee.) 1987-89 Master’s degree (In the laboratory of J.K. Bhattacharjee.) 1986-87 Senior Medical Laboratory Scientist (Microbiology), North Middlesex Hospital, London,

England. 1982-86 Medical Laboratory Scientist, One year as Supervisor, Microbiology Department, King

Faisal Specialist Hospital, Riyadh, Saudi Arabia.

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Publications—All peer reviewed

Since joining MSU—student names in italics

Current Understanding of Celiac Sprue: Analyzing the Manifestation of Type 1 Celiac Disease (2016).

Schuster, H, Haynes, T and R. C. Garrad. (Accepted Logos, Missouri State University, Honors College

Journal)

Comparative biochemistry of bio-metal and bio-metal oxide nanoparticles: enzyme and melanoma specificity

and inhibition of the metastatic phenotype in a 3-D culture model. DeLong, R.K., Mitchell, J., Morris, R.T.,

Comer, J., Mudge, M. C., Hurst, M.N., Washington, L.L., Risor-Marhanka, A., Thomas, S., Ghosh, K.,

Schaeffer, A. M., Marroquin, S., Lekey, A., Smith J. J., Garrad, R., Wanekaya, A., Aryal, S., Abdelhakiem,

M., Glaspell, G. Submitted to Nanomedicine: Nanotechnology, Biology, and Medicine 2016 (Impact factor

6.155)

Characterization of biomolecular nanoconjugates by high-throughput delivery and spectroscopic difference.

(2012) Delong RK, Risor A, Kanomata M, Laymon A, Jones B, Zimmerman SD, Williams J, Witkowski C,

Warner M, Ruff M, Garrad R, Fallon JK, Hickey AJ, Sedaghat-Herati R. Nanomedicine (Lond).

Dec;7(12):1851-62. doi: 10.2217/nnm.12.70. Epub 2012 Sep 3. (Impact factor 5.41)

Neuroprotective roles of the P2Y(2) receptor. (2012) Weisman GA, Ajit D, Garrad R, Peterson TS, Woods

LT, Thebeau C, Camden JM, Erb L. Purinergic Signal. Sep;8(3):559-78. doi: 10.1007/s11302-012-9307-6.

Epub Apr 14. Review. (Impact factor 3.886)

Association of poly I:C RNA and plasmid DNA onto MnO nanorods mediated by PAMAM. (2012) Parker-

Esquivel B, Flores KJ, Louiselle D, Craig M, Dong L, Garrad R, Ghosh K, Wanekaya A, Glaspell G,

DeLong RK. Langmuir. Feb 28;28(8):3860-70. doi: 10.1021/la203998r. Epub 2012 Feb 14. (Impact factor

4.457) Interaction of MnO and ZnO nanomaterials with biomedically important proteins and cells. (2009) Gann H,

Glaspell G, Garrad R, Wanekaya A, Ghosh K, Cillessen L, Scholz A, Parker B, Warner M, Delong RK. J

Biomed Nanotechnol. 2010 Feb;6(1):37-42. (Impact factor 5.338)

Introduction to Neural Stem Cells; A brief look at History, Current Methodology and Recent Advances (2009) Review. Keaster, A and R.C.Garrad (Accepted Logos, Missouri State University, Honors College Journal) Characterization and performance of nucleic acid nanoparticles combined with protamine and gold. (2009) R.K. DeLong, U. Akhtar, M. Sallee, B. Parker, S. Barber, J. Zhang, M. Craig, R.C.Garrad, A. Hickey and E. Engstrom. Biomaterials. Nov;30(32):6451-9 Shujuan Guo, Richard C. Garrad and J.K. Bhattacharjee (2006). Functional analysis through site-directed mutations and phylogeny of the Candida albicans LYS-encoded saccharopine dehydrogenase. Mol Gen Genomics 275 74-80. Rosa V. Flores, Edna Aquino, Melvin G. Hernandez-Perez, Richard C. Garrad, Gary A. Weisman and Fernando A. Gonzalez (2005). The agonist-induced phosphorylaton and desensitization of the P2Y2 nucleotide receptor. Mol Cell Biochem. Dec;280(1-2):35-45. Jun Liu, Zhongji Liao, Jean Camden, Korey D. Griffin, Richard C. Garrad, Laura I. Santiago-Pérez, Fernando A. González, Cheikh I. Seye, Gary A. Weisman, and Laurie Erb (2004). SH3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, Pyk2, and growth factor receptors. J. Biol. Chem. 279 (9) 8212-8218.

http://www.ncbi.nlm.nih.gov/pubmed/22943129

http://www.ncbi.nlm.nih.gov/pubmed/22528682

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Cheikh I. Seye, Qiongman Kong, Laurie Erb, Richard C. Garrad, Brent Krugh, Fernando Gonzalez, and Gary A. Weisman (2002). P2Y2 nucleotide receptors promote intimal hyperplasia in collared rabbit carotid arteries. Circulation. 2002 Nov 19; 106(21):2720-6 Weisman, G.A, Griffin, K., Santiago-Perez, L.I., Liu, J., Krugh, B., Flores, R.V., Chorna, R.N., Santos-Berrios, C., Vivas-Mejia, P.E., Garrad, R.C., Gonzalez, F.A. and L. Erb (2001). P2Y2 receptors regulate multiple signal transduction pathways in monocytic cells. Drug Development Research 53 186-192.

Prior to joining MSU

Santiago-Pérez, L. I., Flores, R. V., Santos-Berríos, C., Chorna, N. E., Krugh, B., Garrad, R. C., Erb, L., Weisman, G. A. and F. A. González (2001). P2Y2 nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases. J. Cell. Physiol. 187 196-208. Erb, L., Liu, J., Ockerhausen, J., Garrad, R.C., Griffin, K., Neal, C., Santiago-Perez, L.I., Gonzalez, F.A., Gresham, H.D., Turner, J.T. and G.A. Weisman (2001). An arginine-glycine-aspartic acid sequence in the P2Y2 nucleotide receptor mediates interactions with v3/5 integrins and is required for Go-mediated signal transduction. J. Cell Biol. 153(3) 491-501 Velazquez, B., Garrad, R.C., Weisman, G.A. and F.A. Gonzalez (2000). Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP. Mol. and Cell. Biochem. 206 75-89 Otero, M, Garrad, R.C., Velazquez, B., Camden, J.M., Erb, L., Clarke, L.L., Turner, J.T., Weisman, G.A. and F.A. Gonzalez (2000). Agonist-induced protein kinase C-independent desensitization of a recombinant P2Y2 nucleotide receptor. Mol. and Cell. Biochem. 205 115-123. Clarke, L.L., Harline, M.C., Otero, M.A., Glover, G.G., Garrad, R.C., Krugh, B., Walker, N.M., Gonzalez, F.A., Turner, J.T. and G.A. Weisman (1999). Desensitization of P2Y2 receptor-activated transepithelial anion secretion. Am. J. Physiol. 4 Pt 1 C777-787. Weisman, G.A., Garrad, R.C., Erb, L., Santos-Berrios, C., and F. A. Gonzalez. (1999) P2Y receptors in the nervous system: molecular studies of a P2Y2 receptor subtype from NG-108-15 neuroblastomaglioma hybrid cells. Prog. In Brain Res. 120 33-43. Weisman, G.A., Erb, L. Garrad, R.C., Theiss, P.M., Santiago-Perez, L.I., Flores, R.V., Santos-Berrios, C., Mendez, Y., and F. A. Gonzalez. (1998) P2Y nucleotide receptors in the immune system: signaling by a P2Y2 receptor in U937 monocytes. Drug. Dev. Res. 45 222-228. Garrad, R.C., Otero, M. A., Erb, L., Theiss, P. M., Clarke, L. L., Gonzalez, F. A., Turner, J. T. and G. A. Weisman (1998). Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor: consequences of truncation of the C-terminus. J. Biol. Chem. 273 (45) 29437-29445 Weisman, G.A., Garrad, R.C., Erb, L., Otero, M., Gonzalez, F.A., and L. L. Clarke (1998). Structure and function of P2Y2 nucleotide receptors in cystic fibrosis (CF) Epithelium. Adv. Exp.Med. 431 417-424. Park, M-J, Garrad, R. C., Weisman, G.A. and J.T. Turner (1997). Changes in P2Y1 nucleotide receptor activity during the development of the rat salivary gland. Am. J. Physiol. (Cell Physiol. 41), C1388-C1393. T. Nguyen, Erb, L., Weisman, G. A., Marchese, A., Heng, H. H. Q., Garrad, R. C., George, S. R., Turner, J. T., and B. F. O'Dowd (1995). Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem. 270 (52): 30845-30848. Erb, L., Garrad, R., Quinn, T., Turner, J. T. and G. A. Weisman (1995). Site-directed mutagenesis of P2U nucleotide receptors (positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity). J. Biol. Chem. 270 4185-4188.

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Garrad, R., Schmidt, T.S. and J. K. Bhattacharjee (1994). Molecular and functional analysis of the LYS1 gene of Candida albicans. Infection and Immunity 62 #11 5027-5031. Garrad, R.C. and J.K. Bhattacharjee (1992). Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans. J. Bacteriol. 174 #22 7379-7384. Ye, Zhi-Hai., Garrad, R.C., Winston, M.K. and J.K. Bhattacharjee (1991). Use of α-aminoadipate and lysine as sole nitrogen source by Schizosaccharomyces pombe and selected pathogenic fungi. J. Basic Microbiol. 2 : 149-156.

Book Chapters and Reviews Weisman, G.A., Turner, J.T., Clarke, L.L., Gonzalez, F.A., Otero, M., Garrad, R.C., and L. Erb, (1997) P2 nucleotide receptor structure and function. In: Ecto-ATPases; Recent progress on structure and function pp 231-39 Eds Plesner, L., Kirley, T.L. and A.F. Knowles. Plenum Publ. Co., New York, NY, USA.

Weisman, G. A., Gonzalez, F.A., Erb, L., Garrad, R.C., and J.T.Turner. (1997) The cloning and expression of G protein-coupled P2Y nucleotide receptors. In “The Receptors; The P2 nucleotide receptors” pp 63-80. Eds. Turner, J.T., Weisman, G.A., and J. Fedan. Publishers Humana Press. van Rhee, A.M., Jacobson, K.A., Garrad, R.C., Weisman, G. A., and L. Erb. (1997) P2 receptor modeling and identification of ligand binding sites. In “The Receptors; The P2 nucleotide receptors” pp 135-169. Eds. Turner, J.T., Weisman, G.A., and J. Fedan. Publishers Humana Press. Lustig, K.D., Weisman, G.A., Turner, J.T., Garrad R., Shiau, A.K., and Erb, L. (1996) P2U purinoceptors: cDNA cloning, signal transduction and structure-function analysis. In: P2 purinoceptors: localization, function and transduction mechanisms (D.J. Chadwick and J.A. Goode, eds.). John Wiley & Sons Ltd., Chichester, UK. Vol. 198, pp. 193-207.

Abstracts published

Jackson, A., and R.C.Garrad (2008). Cysteine 278 of the murine P2Y2 receptor affects desensitization. Transactions of the Missouri Academy of Science 42. Schiller, A., and R.C.Garrad (2008). The effect of C-terminal alterations of the P2Y2 receptor on calcium signaling and desensitization. Transactions of the Missouri Academy of Science 42. Masterson, C., and R.C.Garrad (2008). The effect of ATP on apoptosis in an estrogen-independent breast cancer cell line. Transactions of the Missouri Academy of Science 42. Pacheco, J., M, Oltman, M. and R.C. Garrad (2006). Characterizing P2 receptors on MDA-MB-231 breast cancer cells and implications in apoptosis. Transactions of the Missouri Academy of Science, 40.

Glauser, H.M. and R. C. Garrad (2004). The effect of C-terminal tail mutations on desensitization of the P2Y2 nucleotide receptor. Transactions of the Missouri Academy of Science, 38. Tucker, D.K. and R.C. Garrad (2004). The effect of protein kinase C inhibition on P2Y2 desensitization. Transactions of the Missouri Academy of Science, 38. O’Donnell, J.D. and R.C. Garrad (2003). Site-directed mutagenesis of the P2Y2 nucleotide receptor. Transactions of the Missouri Academy of Science, 37. Groh, M.J. and R.C. Garrad (2003). Regulation of P2Y2 receptor desensitization. Transactions of the Missouri Academy of Science, 37.

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Garrad, R.C., Gonzalez, F.A. and Weisman, G.A. (2002). The effect of protein kinase C inhibition on P2Y2 receptor desensitization in 1321N1 astrocytoma cells. Molecular Biology of the Cell, 13:S 80a. Garrad, R.C., Gonzalez, F.A. and Weisman, G.A. (2002). Inhibition of P2Y2 receptor desensitization by inhibition of protein kinase C activity. Transactions of the Missouri Academy of Science, 36.

Prior to joining MSU (5 of 15)

Santiago-Pérez, L. I., Flores, R. V., Santos-Berríos, C., Chorna, N. E., Krugh, B., Garrad, R. C., Erb, L., Weisman, G. A. and F. A. González (2001). P2Y2 nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases. J. Cell. Physiol. 187 196-208. Erb, L., Liu, J., Ockerhausen, J., Garrad, R.C., Griffin, K., Neal, C., Santiago-Perez, L.I., Gonzalez, F.A., Gresham, H.D., Turner, J.T. and G.A. Weisman (2001). An arginine-glycine-aspartic acid sequence in the P2Y2 nucleotide receptor mediates interactions with v3/5 integrins and is required for Go-mediated signal transduction. J. Cell Biol. 153(3) 491-501 Velazquez, B., Garrad, R.C., Weisman, G.A. and F.A. Gonzalez (2000). Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP. Mol. and Cell. Biochem. 206 75-89 Otero, M, Garrad, R.C., Velazquez, B., Camden, J.M., Erb, L., Clarke, L.L., Turner, J.T., Weisman, G.A. and F.A. Gonzalez (2000). Agonist-induced protein kinase C-independent desensitization of a recombinant P2Y2 nucleotide receptor. Mol. and Cell. Biochem. 205 115-123. Clarke, L.L., Harline, M.C., Otero, M.A., Glover, G.G., Garrad, R.C., Krugh, B., Walker, N.M., Gonzalez, F.A., Turner, J.T. and G.A. Weisman (1999). Desensitization of P2Y2 receptor-activated transepithelial anion secretion. Am. J. Physiol. 4 Pt 1 C777-787.

I was chair of the graduate committees of (current positions in italics) Hillary Glauser (MS in CMB July 2004)—Faculty member, Southwest Baptist University Dana Tucker (MS in CMB 2005)—Post Doctoral, U of Kansas Daniel Short (MS in CMB 2007) Laveena Kondagari (MS in CMB 2008)—Medical resident Caleb Masterson (MS in CMB 2008)—Medical resident Amy Schiller (MS in CMB 2009)—Doctor of Pharmacy, Part time instructor, MSU Chad Walesky (MS in CMB 2009)—Post Doctoral, Harvard U Raja Thotakura (MS in CMB 2009)—Medical resident Lucas Bradley (MS in CMB 2011)—Medical resident Ryan McNutt (MS in CMB 2011)--Dentist Jon Ramsey (MS in CMB 2013) Katie McLemore (MS in CMB 2014)—Attending St. Louis School of Pharmacy Dan Louiselle (MS in CMB 2014)—Attending PhD program at Washington Univ Kendal Wallace (MS in CRNA 2006). Andrea Baldwin (MS in CRNA 2007) Doug Stelzer (MS in CRNA 2007) Glenn McLendon (MS in CRNA 2008) Kelly Ruise (MS in CRNA 2008) Brad Foss (MS in CRNA 2008) Nick Koval (MS in CRNA 2009) Jenee Gimson (MS in CRNA 2010) Sarah Kruse (MS in CRNA 2010) Amanda Jones (MS in CRNA 2010) April Steeps (MS in CRNA 2011) Jill Tracy (MS in CRNA 2011)

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Herbert Nyoni (MS in CRNA 2011) I have served on the graduate committees of David Stone (MS in CMB 2005) Srilatha Nalluri (MS in CMB 2006) Courtney Eaves (MS in CMB 2007) Hinda Doucoure (MS in CMB 2008) Joe Williams (MS in CMB 2009) Brooke Parker (MS in CMB 2010) Amruta Ashtekar (MS in CMB 2011) Daniel Elbrecht (MS in CMB 2013) John Dean (MS in CMB 2014) Miranda Mudge (MS in CMB 2014) Joseph Harvey (MS in CMB 2014) Ashley Schaeffer (MS in CMB 2014) Chris-Anne Crabtree (MS in CRNA 2006) Melanie Lewis (MS in CNRA 2006) Diane Thomas (MS in CRNA 2007) Marian Kindberg (MS in CRNA 2007) Chris Regier (MS in CRNA 2007) Miranda Evans (MS in CRNA 2008) Reggie Maggard (MS in CRNA 2009) Adrian Fain (MS in CRNA 2009)

I am currently the chair of the following graduate student committees, Thu Ngo (MS in CMB candidate)

Each semester I have undergraduate students performing undergraduate research (BMS498). The students that have performed research in my laboratory since July 2004 are given with the credit hours in parentheses. Those students who have further aspirations in higher education are listed in italics. Brian Haas SP05(2), SU05(2), FA05(2),

SP06(2)—PhD program U of Alabama Jose Pacheco SU05(2), FA05(2), SP06(2)—

Med School Mary Timson FA05(2)--PhD program U of

Tennessee Ashley Fischer SP05(2)--Lead researcher,

Sigma Biochemicals Michaela Milan SP05(2) Alyssa Bessent SP06(2) Amanda Diagula SP06(2)—Med School Jenni Gillespie FA06(2),SP07(2)—Med

School Hannah Nugent FA06(2),SP07(2),

SP08(1)—Med School Caleb Masterson FA06(2)—Med School Jenna Lantgen FA06(2),SP07(2) Jayne Kristman SP07(2)—PA School Austin Jackson SU07(2), FA07(2),

SP08(2)—PhD program U of S. Carolina

Neal Dewoody SU07(2), FA07(2) Michael Perry SP08(1) Brooke Parker SP08(2) Drew Keaster FA07(2), Sp08(2)—Med

School Matthew Stickney SP08(2) Uzma Akhtar SP09(2)—Doctor of

Audiology Program MSU Michael Ruff FA08(2),SP09(2)—Med

School Thomas Spears FA08(2)—Med School Justin Lawson SP09(2) Thomas Brake SP09(2) Larkin O’Quinn SP09(1) Jeremy Baeten SP10(1), FA10 (1)—PhD program Ohio State U Noah Buboltz SP10 (1)—Med School John Donaldson SP10(1), FA10 (1) Katie McLemore FA10(1),SP11(1)—St. Louis College of Pharmacy

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Dan Louiselle SP11(1)—PhD program Washington U Mick Kelling FA11(1),SP12(1) Travis Bell SP12(1) Lucas Bondurant SP12(1),FA12(1),SP13(1),FA13(1),SP14(1)—PhD program U of Iowa Michael Gulley SP14(1)—Dental School

Jereme Sebastian SP14(1) —Dental School Jennifer Copeland FA14(1),SP15(1)—MS program at MSU Rebecca Newth SP15(1),FA15(1)— PhD program, U of Missouri Emily Smith SP15(1) Taylor Clifton FA15(1)—Applying to Med School

Other undergraduates who have performed research in the lab (prior to 2004). Joshua O’Donnell Thomas Slavin Zachary Hugo Dustin Tripp Nicholas Gentry Jade Ponder Jason West

Journal/Grant Reviews Ad hoc reviewer for NIH BRIN-PR grant applications (2001 & 2002) Ad hoc reviewer for the University of Missouri Research Board and the Wellcome Trust (UK) Reviewer for American Journal of Physiology Served as a reviewer for the Journal of Immunology Ad Hoc reviewer for PLOS (Public Library of Science) ONE

Grants/Fellowships Current NIH R15-AREA grant “Anti-cancer RNA conjugates”. Robert Delong, Richard Garrad, Kartik Ghosh, Adam Wanekaya, CoIs 10% total effort Total award $398,000 Funded until 2/1/2017. Past NIH-R15 AREA Grant, (7/1/09-6/30/12) Anti-cancer RNA Nanoconjugates—Robert Delong PI Co-I Total award: $189,000 (1% effort) Major Research Instrumentation Grant (NSF) 2009 Spinning laser confocal microscope—Kyongtae Kim PI Collaborator

North American Biotechnology Company research grant (2008) “Analysis of genes from S. cerevisiae”—PI R.C. Garrad Total Award~$13,000 (10% effort)

NIH-AREA Grant, (7/1/04-6/30/07). Mitogenic pathway regulation by P2Y2 receptors. PI Total award: $179,289. (30% effort) NIH-National Institutes on Aging, Program Project grant, (1/1/01-12/31/06) Cell models for AD: Lipids and related signaling pathways. Gary Weisman PI Co-Investigator (30% effort)

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Public Affairs grant (2006) Brought Dr. Michael Zemel, world expert on nutrition and obesity for campus and community-wide seminar. NIH-RCMI program (7/1/00-6/30/04) Desensitization of P2Y2 nucleotide receptors and implications for novel nucleotide based therapies. Gary Weisman PI. Co-Investigator (30% effort) Funded, $99,783 for 1st year, $423,725 total Faculty Research grant (2002) “The use of dominant negative mutants in the determination of P2Y2 receptor desensitization pathways”. Total: $6300 Public Affairs grant for National Academy of Science member Dr. Michael Roberts’ campus wide seminar (2002) Total: $778 Cystic Fibrosis Foundation--National Post-Doctoral Research Fellowship (5/97-5/99). Regulation of P2Y2 Nucleotide Receptors: Role in the Therapy of Cystic Fibrosis. ($68,000) Funds made available from the Graduate College for recruiting trips Fall 2001 ($200) Sigma Xi grant in aid of research (1989). Lysine Biosynthesis in Pathogenic Fungi. ($400) Grant awarded but not funded for administrative reasons Academic Research Enhancement Award (R15) “DNA vaccines for tuberculosis”—Consultant R.C. Garrad (Delong PI)

Submitted not funded since MSU start date NSF grant in conjunction with Dr Colette Witkowski MRI RUI Acquisition of a Laser Scanning Confocal Microscope to expand collaborative research and teaching potential at Missouri State University. 2015 NSF grant in conjunction with Dr Colette Witkowski MRI RUI Acquisition of a Laser Scanning Confocal Microscope to expand collaborative research and teaching potential at Missouri State University. 2014 NSF grant in conjunction with Dr Colette Witkowski MRI RUI Acquisition of a Laser Scanning Confocal Microscope to expand collaborative research and teaching potential at Missouri State University. 2013 NSF grant in conjunction with Dr Colette Witkowski MRI RUI Acquisition of a Fluorview 100s Spectral SIM Confocal Microscope to expand collaborative research and teaching potential at Missouri State University. 2012 Wang, Jianjie (Principal), Witkowski, Colette (Co-Principal), Garrad, Richard C (Co-Principal), Levesque, Chantal (Co-Principal) 2010 "Integrating Microcirculation Laboratory into Undergraduate Curriculum," Sponsored by National Science Foundation, Transforming Undergraduate Education in Science (TUES), Federal. Missouri Life Sciences Research Board “Point-of-Care Strips for the Detection of Cancer Marker and other Proteins” Adam Wanakaya PI Co-I Keck Foundation research award (2009) “RNA vaccination with gold microparticles” Robert Delong PI Co-PI NIH-AREA Grant application, submitted 9/25/2002. Mitogenic pathway regulation by P2Y2 receptors. Amount requested: $69,800 first year, $139,600 total.

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NIH RO1 grant application, submitted 10/01/2002. P2Y2 receptor signaling and membrane microdomains. Fernando Gonzalez, University of Puerto Rico, PI, R.C. Garrad, Collaborator.

Professional Meetings/Abstracts

Since joining MSU

Jianjie Wang Joseph Harvey, Aparna Tiwari, Laurie Erb, Virginia Huxley, Gary Weisman and Richard Garrad. Focal adhesion kinase mediates P2Y2 receptor-dependent increased endothelial permeability. Experimental Biology Meeting, San Diego, CA. Fall 2014. Lucas Bondurant, Daniel Louiselle, Katie McLemore and Richard Garrad. Mapping the desensitization pathway of the P2Y2 receptor through knockdown of regulatory proteins. CHHS research symposium April 2014. DeLong, Robert (Presenter), Sedaghat-Herati, Reza, Wanekaya, Adam K, Smith, Joshua J., Garrad, Richard

C, Wang, Jianjie, Morris, Tyler, Brodeur, Amanda, Dean, John, Mudge, Miranda, Mitchell, Jennifer, Lekey,

Amber, Greene, Thomas, Ashley, Schaeffer, Ghosh, K, Cotrell, Kyle, Joseph, McGreevy, Abdelhakim,

Mohammed, Hickey, AJ, Glaspell, Gary. 3rd International Conference on Nanotek and Expo, "Characterization

of Novel RNA, Protein and Chimera Nanoconjugate Composites and Their Pre-Clinical Application," OMICS

Group, Las Vegas, NV. (December 3, 2013). DeLong, Robert (Presenter), McGreevy, Joseph, Flores, Kristin, Abdelhakiem, Mohamed, Garrad, Richard C,

Ghosh, Kartik C, Craig, Michael M, Wanekaya, Adam K, Glaspell, Garry P. International RNA

Nanotechnology and Therapeutics Conference, "TOWARD THE RATIONAL PRE-CLINICAL

APPLICATION OF NANOMATERIAL RNA AND PROTEIN CONJUGATES," University of Kentucky.

(April 5, 2013). Joseph Harvey, Richard Garrad and Jianjie Wang. The role of focal adhesion kinase in P2Y2 receptors—induced signaling pathway in microvascular endothelial cells. IDF Spring 2012 Flores, Kristin J (Presenter), Craig, Michael M, Dong, Lifeng, Garrad, Richard C, Ghosh, Kartik C,

Wanekaya, Adam K, DeLong, Robert, Nanofrontiers 2011, "Association of Poly I:C RNA onto MnO Nanrods

Mediated by PAMAM," State of Missouri, Missouri State University. (October 26, 2011). Veneuturmilli, Sindhuri (Presenter), Smith, Joshua J., Craig, Michael M, Garrad, Richard C, DeLong, Robert, Nanofrontiers 2011, "Formation of Non-Sedimentable Poly-acrylic acid nanoparticles with cobalt hexamine," State of Missouri, Missouri State University. (October 26, 2011). Masaaki Kanomata, Azure Risor, Brooke Jones, Laurie Washington, Joseph Williams, Scott Zimmerman, Reza Sedaghat-Herati, Robert DeLong and Richard Garrad. High Throughput Absorbance and Fluoescence Difference Spectroscopy in the Delivery of Biomolecular Nanoconjugates. CHHS research symposium April 2011. Washington, Laurie, Glaspell, Garry, Li, Jiang, Garrad, Richard C, Witkowski, Colette, Wanekaya, Adam K, Ghosh, Kartik C, DeLong, Robert, Nanofrontiers 2010, "Biophysical Characteristics of Zinc Oxide Nanomaterials and Their Interactions with Proteins and Cancer Cells," Washington University - St. Louis, St. Louis, MO. (October 27, 2010). Parker, Brooke D, Craig, Michael M, Garrad, Richard C, Wanekaya, Adam K, Ghosh, Kartik C, Dong, Lifeng, DeLong, Robert, Missouri Academy of Science, "Potential Nucleic Acid Delivery Agent: Binding of Macromolecular RNA Onto MnO Nanorods Mediated by PAMAM," Missouri State University, Springfield, MO. (April 17, 2010).

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Cillessen, Lisa, Warner, Matt, McNew, Jenna, Barber, Stephanie, Parker, Brooke Esquivel, Wanekaya, Adam K, Ghosh, Kartik C, Dong, Lifeng, Craig, Michael M, Garrad, Richard C, DeLong, Robert, Biological Sciences, "Binding, Stabilization, and Delivery of Therapeutic RNA," Missouri Academy of Science, Missouri State University, Springfield, MO. (April 16, 2010). Cillessen, Lisa, Warner, Mathew, McNew, Jenna, Barber, Stephanie, Parker, Brooke Esquivel, Wanekaya, Adam K, Ghosh, Kartik C, Dong, Lifeng, Craig, Michael M, Garrad, Richard C, DeLong, Robert, RNA and Oligonucleotide Therapeutics, "Binding, stabilization and delivery of therapeutic RNA," Cold Spring Harbor, Cold Spring Harbor, NY. (April 8, 2010). Akhtar, U., Gillihan, R., Garrad, R.C. and R.K. DeLong (2009) Towards nanoparticle gene vaccines-model studies on their delivery to cultured human cells. Missouri Academy of Sciences, April 25th, Seminar presentation. Ruff, M.W.,Delong, R.K. and R.C.Garrad (2009) Isolation and cloning of Mycobacterium tuberculosis H37Rv Ag 85B. Missouri Academy of Sciences, April 25th, Seminar presentation. Jackson, A., and R.C.Garrad (2008), Cysteine 278 of the Murine P2Y2 Receptor Affects Desensitization. Missouri Academy of Science, April 19th, Seminar presentation. Schiller, A., and R.C.Garrad (2008), The Effect of C-terminal Alterations of the P2Y2 Receptor on Calcium Signaling and Desensitization. Missouri Academy of Science, April 19th, Seminar presentation. Masterson, C., and R.C.Garrad (2008), The Effects of ATP on Apoptosis in an Estrogen-independent Breast Cancer Cell Line. Missouri Academy of Science, April 19th, Seminar presentation. Pacheco, J., M, Oltman, M. and R.C. Garrad (2006). Characterizing P2 receptors on MDA-MB-231 breast cancer cells and implications in apoptosis. Missouri Academy of Science, April 22nd, Seminar presentation. Pacheco, J., M, Oltman, M. and R.C. Garrad (2006). Characterizing P2 receptors on MDA-MB-231 breast cancer cells and implications in apoptosis. Tenth Annual College of Health and Human Services Research Symposium, April 6th, Poster presentation. Glauser, H.M. and R. C. Garrad (2004). The effect of C-terminal tail mutations on desensitization of the P2Y2 nucleotide receptor. Kansas and Missouri Academies of Science, April 17th, Seminar presentation. Tucker, D.K. and R.C. Garrad (2004). The effect of protein kinase C inhibition on P2Y2 desensitization. Kansas and Missouri Academies of Science, April 17th, Seminar presentation. Tripp, D.R. and R.C. Garrad (2004). Analysis of receptor density using fluorescence microscopy; a step towards a better treatment for cystic fibrosis. Eighth Annual College of Health and Human Services Research Symposium, April 22nd, Poster presentation. Tucker, D.K. and R.C. Garrad (2004). The effect of protein kinase C inhibition on P2Y2 desensitization. Eighth Annual College of Health and Human Services Research Symposium, April 22nd, Poster presentation. O’Donnell, J.D. and R.C. Garrad (2003). Site-directed mutagenesis of the P2Y2 nucleotide receptor. Missouri Academy of Sciences, Central Missouri State University, April 18-19th, Seminar Presentation. Groh, M.J. and R.C. Garrad (2003). Regulation of P2Y2 receptor desensitization. Missouri Academy of Sciences, Central Missouri State University, April 18-19th, Seminar Presentation. O’Donnell, J.D. and R.C. Garrad (2003). The effects of site-directed mutations on P2Y2 nucleotide receptor expression, sequestration and desensitization. College of Health and Human Services, Student Research Symposium, April 24th, Poster Presentation.

R.C.Garrad 5

Groh, M.J. and R.C. Garrad (2003). Regulation of P2Y2 receptor desensitization. College of Health and Human Services, Student Research Symposium, April 24th, Poster Presentation. Glauser, H.J. and R.C. Garrad (2003). The effect of C-terminal mutations on desensitization of the murine P2Y2 nucleotide receptor. College of Health and Human Services, Student Research Symposium, April 24th,

Poster Presentation. Garrad, R.C., Gonzalez, F.A. and Weisman, G.A. (2002). The effect of protein kinase C inhibition on P2Y2 receptor desensitization in 1321N1 astrocytoma cells. Annual Meeting of the American Society of Cell Biology, San Francisco, CA, December 14-18th, Poster presentation. Garrad, R.C., Gonzalez, F.A. and Weisman, G.A. (2002). Inhibition of P2Y2 receptor desensitization by inhibition of protein kinase C activity. Missouri Academy of Sciences Meeting, April 19-20th, Seminar presentation. O’Donnell, J.D., Slavin, T. and R.C. Garrad (2002). Site directed mutagenesis of the recombinant P2Y2 nucleotide receptor. College of Health and Human Services, Student Research Symposium, April 18th, Poster Presentation.

Prior to joining MSU Garrad, R.C. (1999) Role of PKC activity in P2Y2 receptor desensitization. Invited Seminar at the 2nd Annual Membrane Biology Conference, University of Missouri-Columbia. Garrad, R.C., Gonzalez, F.A. and G.A. Weisman (1999). Inhibition of P2Y2 receptor desensitization by downregulation of protein kinase C activity. Thirteenth Annual North American Cystic Fibrosis Conference, October 7-10, Seattle, WA. Pediatric Pulmonology, 16. Garrad, R.C., Otero, M.A, Gonzalez, F.A., Turner, J.T. Clarke, L.L. and G.A. Weisman (1998). Desensitization of the P2Y2 receptor; implications for the therapy of cystic fibrosis. Invited Seminar at the 6th International Symposium on Adenine and Adenine Nucleotides; Ferrara, Italy. Garrad, R.C., Otero, M.A., Erb,L., Turner, J.T., Gonzalez, F.A., Clarke, L.L., and G.A. Weisman (1997). Alterations of the C-terminal tail of the P2Y2 nucleotide receptor affect receptor desensitization and sequestration. Eleventh Annual North American Cystic Fibrosis Conference, October 23-26, Nashville TN. Pediatric Pulmonology, 14. Otero, M.A., Garrad, R.C., Erb, L., Clarke, L.L., Gonzalez, F.A. and G.A. Weisman (1997). Regulation of P2 receptor desensitization by ectoATPase activity in epithelial cells. Eleventh Annual North American Cystic Fibrosis Conference, October 23-26, Nashville TN. Pediatric Pulmonology, 14. Garrad, R.C., Otero, M.A., Erb, L., Clarke, L.L., Gonzalez, F.A., Turner, J.T. and G.A. Weisman. (1997) Mechanisms of P2Y2 nucleotide receptor desensitization, implications for cystic fibrosis pharmacotherapy. Annual Meeting of the American Society of Biochemistry and Molecular Biology, August 24-27, San Francisco CA. FASEB Journal Abstracts Vol. 11 #9. Garrad, R.C., Otero, M.A., Camden, J., Clarke, L.L., Gonzalez, F.A., Turner, J.T. and G.A. Weisman (1996). Directed mutagenesis of P2Y2 nucleotide receptor PKC phosphorylation sites decreases receptor desensitization. Tenth Annual North American Cystic Fibrosis Conference, October 24-27, Orlando FL. Pediatric Pulmonology, 13. Harline, M.C., Price, E.M., Glover, G.G., Garrad, R.C., Weisman, G.A., Turner, J.T. and L.L. Clarke (1996). Increased Ca2+-mediated Cl- conductance in a transformed epithelial cell line from the CFTR knockout mouse. Tenth Annual North American Cystic Fibrosis Conference, October 24-27, Orlando FL. Pediatric Pulmonology, 13.

R.C.Garrad 6

Weisman, G.A., Turner, J.T., Erb, L., Garrad, R.C., Harline, M.C., Otero, M.A., Glover, G.G., Camden, J.M., Gonzalez, F.A. and L.L. Clarke (1996). P2Y2 nucleotide receptor structure and function: relevance to cystic fibrosis pharmacotherapy. Tenth Annual North American Cystic Fibrosis Conference, October 24-27, Orlando FL. Pediatric Pulmonology, 13. Erb, L., Garrad, R., Clarke, L.L, Turner, J.T., and G.A. Weisman (1995). Site-directed mutagenesis of recombinant P2U purinoceptors to ascertain structural determinants relevant to cystic fibrosis therapies. Ninth Annual North American Cystic Fibrosis Conference, October 12-15, Dallas, TX. Pediatric Pulmonology, 12: 235. Otero, M., Camden, J.M., Erb, L., Garrad, R.C., Gonzalez, F.A., Clarke, L.L., Weisman, G.A., and J.T. Turner (1995). Regulation of native and heterologously expressed P2U purinoceptors. Ninth Annual North American Cystic Fibrosis Conference, October 12-15, Dallas, TX. Pediatric Pulmonology, 12: 235. R.C. Garrad, Erb, L., Weisman, G.A. and J.T. Turner (1995). Investigation of the ligand binding site of the P2Y purinoceptors. Experimental Biology ‘95. Atlanta GA. Erb, L., Garrad, R., Ockerhausen, J. E., Sullivan, D.M., Parr, C.E., Gresham, H., Boucher, R., Turner, J.T. and G. A. Weisman (1994). Expression, identification and site-directed mutagenesis of human and murine P2U receptors. 5th International Symposium on Adenine and Adenine Nucleotides; From Molecular Biology to Integrative Physiology, Philadelphia Pennsylvania. Garrad, R., Schmidt, T. M. and J.K. Bhattacharjee (1993). Molecular and functional analysis of the LYS1 gene of Candida albicans. Annual Meeting ASM, Atlanta Georgia. Ford, R. F., Garrad, R. C., Rajnaryan, S. R., and J.K. Bhattacharjee (1992). Lysine genes of Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida albicans. Annual Meeting of the Ohio Academy of Science, University of Akron, Ohio. Ford, R. F., Garrad, R. C., Rajnaryan, S. R., and J.K. Bhattacharjee (1991). Molecular studies of the cloned lysine genes of yeast. Annual Meeting, Ohio and Allegheny Branches, ASM, Salt Fork State Park, Ohio. Garrad, R. C., and J.K. Bhattacharjee (1990). Gene-enzyme relationship and biochemical characterization of lysine auxotrophs of Candida albicans. Annual Meeting, ASM, Anaheim California. Garrad, R. C., and J.K. Bhattacharjee (1990). Characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans. Annual Meeting, Ohio and Allegheny Branches, ASM, Mt. Sterling, Ohio. Garrad, R. C., and J.K. Bhattacharjee (1989). Lysine biosynthesis in Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. Annual Meeting, ASM, New Orleans Louisiana. Garrad, R.C., and J.K. Bhattacharjee (1988). Lysine biosynthesis in pathogenic fungi. Annual Meeting, Ohio and Allegheny Branches, ASM, Miami University, Oxford, Ohio.

Other seminars

October 11th , 2001 Gave seminar @ Central MO State October 25th , 2001 Gave seminar @ University of Arkansas (Fayetteville) November 1st , 2001 Gave seminar @ NW MO State University December 7th , 2001 Gave seminar @ Truman State University April 4th , 2002 Gave seminar @ Stephens College, Columbia MO Title of above seminars; Cellular signaling via the P2Y2 nucleotide receptor and its implications in human health and disease March 9th, 2006 Missouri State University Provost Research Forum Lecture

R.C.Garrad 7

“Nucleotide Receptors in Health and Disease”, Special presentations

SMSU Interdisciplinary Forum Special Edition: “Perspectives on War with Iraq”. Panel member, October 2002.

Springfield Discovery Center Genome Week: “Cystic Fibrosis”. Poster presentation April 2003. Greene County Medical Society “Somatic cell nuclear transfer” Panel member, March 2005.

Honors

College of Health & Human Services Faculty Research Award, Fall 2003. Southwest Missouri State University. Member of the Graduate Faculty, Missouri State University. Nominated three times for “Excellence in Academic Advising Award”

Teaching Experience Missouri State University BMS 520/521 “Molecular Cell Biology”. BMS 500-701 “Bioterrorism”. BMS 528 “Molecular Mechanisms of Bacterial Pathogenesis” BMS 535 “Signal Transduction” UHC 110 “Freshman Honors Introduction to University Life” BMS 100 “Concepts and Issues in Biomedical Sciences” Discussion section. BMS 321 “Laboratory section of Biomolecular interactions”. BMS 494 “Senior seminar”. BMS 630 “Graduate student seminar” Teaching Load Equivalents (TLEs) for semesters taught since 2004 (normal load 9 TLEs/semester) SP05—14 FA05—15 SP06—14 FA06—19 SP07—14 FA07—16 SP08—16 FA08—16 SP09—10 FA09---12 SP10---10 FA10---12 SP11---11 FA11---10 SP12---14 FA12---9 SP13---10 FA13---7 SP14---10 FA14---8 These calculations do not include hours for research classes University of Missouri-Columbia Lectures in “Principles of Drug Action” 1996/7, 1997/8, 1998/9, 1999/2000, 2000/01 Graduate level pharmacology course discussing current opinions in receptor biology, cell signaling and gene regulation. Lectures in “Neuropharmacology” 1998/9 Graduate level course discussing current issues in the study of neural tissues. Miami University 1987-92

R.C.Garrad 8

Bacteria and the Diseases of Man. (MBI 111) Sole instructor responsible for examinations and grading of a 3 credit hour lecture course, covering the principles and applications of Microbiology. The first half of the course dealt with the understanding of infectious agents and host responses, the second half addressing the specific infectious diseases. Spring 1992 (100 students), Summer 1992 (20 nursing students). DNA Technology for High School Teachers. A month long workshop of lectures and laboratory practicals designed to familiarize teachers with basic molecular biology techniques able to be performed at the High School level. This workshop was supported for three years by NSF (and was subsequently renewed for a further 3 years) and involved 25 selected teachers from within Ohio. Summer 1992. Experimenting with Microbes 1 credit. Laboratory, Fall 1991. Pathogenic Microbiology Laboratory. Spring 1991, Spring 1990, Fall 1988. Co-author of the laboratory manual for this course, “Experiments in Pathogenic Microbiology”, with A.M. Hooke Ph.D. and T.S. Agin M.S. Microbial Physiology Laboratory. Fall 1990, Fall 1989. General Microbiology Laboratory. Spring 1988, Spring 1989.

Service University Committees Chair, Pre-medical Committee (2011-2016) Chair of the Faculty-Student Judicial Commission (2014-present) Member, Faculty Research Grants (Fall 2007 & Spring/Fall 2008) Member, Provost’s Committee on Promotion & Tenure (2008-2014) Member of Presidential Scholars Interview Committee, University Honors College, (2002-present) Member of University Ambassadors Selection Committee, Spring 2005. Member, Campus Student Success faculty advisory committee (2007 & 2008) Member, Campus Radiation Safety Committee (2007-present) Member, Provost’s Initiative Review Committee (Fall 2007) Member of Senate Rules Committee (2010-2011) Member of the Judicial Appeals committee (2010-present) Member of the Provost’s committee on general education review (2010-2012) College Committees Co-chair College of Health & Human Services “Student Research Symposium” April 2003, 84 student presentations April 2004 184 student presentations

R.C.Garrad 9

April 2005 228 student presentations April 2006 95 student presentations April 2007 106 student presentations Chair April 2008, 2009, 2010--126, 101 & 91 student presentations respectively Member, CHHS Dean’s Search Committee (2008) Member of College Awards Committee, College of Health & Human Services, 2004 & 2005, Chair 2006. Member of Scholastic Appeals Committee, College of Health & Human Services, January 2002-present Member of P&T review ctte for Dr. Elizabeth Federman (2013-2015) Member of P&T review ctte for Dr. Kip Thompson (2016) Departmental committees Chair Seminar Committee, Personally invited 50 outside speakers to present at departmental seminar series. Chair, Recruiting and Hiring Committee for new CMB faculty member (2007 & 2008, 2012 (2 committees), 2013 (2 committees)), 2014, 2015) Chair, Reappointment, Promotion and Tenure document review committee (2009-present) Chair, Technology committee (2008-present) Member, Faculty Senate (Fall 2008-2011) Member, Promotion, Tenure & Performance committee (2007-present) Member, Faculty Search Committee, Fall 2004, Fall 2006 & Fall 2008. Member of Graduate and Undergraduate Student Recruitment Committee

Member of Curriculum Committee.

Faculty Mentor for Dr. Amanda Brodeur, Dr. Debbie Piland, Dr. Robert DeLong and Dr. Rehana Lovely, Dr. Jianjie Wang, Dr. Qiong-qiong Zhou, pre-Promotion & Tenure Member, SCUF Committee representative for BMS dept (2007-2011) Other committee service Member, Honors College Committee (2007-present) LOGOS-faculty reviewer (2007-present) Member, Pre-medical Committee (Fall 2008 to present)

R.C.Garrad 10

Other service

Biomedical Sciences Department Representative at various student recruitment fairs.

University Representative at Ronald McNair Scholars Fair, Kansas City, MO 2001.

Organizer of visit to the Stowers Institute, Kansas City, MO for 13 Biomedical Sciences Department students. Organized ~30 hours of “bell ringing” activities with the Springfield Salvation Army during the 2007 & 2008 , 2009, 2010 holiday season Member of MASH camp Summer 2005-2008. Research and Creative Activities Forum judge, University of Missouri-Columbia February 17th, 2007 Participated in Graduate student research workshop (Fall 2008/2009) Served as an external faculty reviewer for Dr. Judith Cole, Promotion and Tenure package, University of Memphis, Fall 2008 Master Advisor (since 2002)—Currently advise ~ 100-120 students. Act to guide students through their college experience. Help with preparation of schedules, give advise on applications for further education, scholarships, internships and fellowships.

Teaching matrix

Departmental requirements in teaching 1Completing assigned teaching workload (18 contact hrs/academic yr; 24 contact hrs/academic year for Instructor rank) (Includes issuing course policies containing standard university-required content, evaluating student performance, updating learning materials, maintaining high performance expectations, and coordinating and supervising teaching assistants if applicable. Excludes independent study, e.g., BMS 498 and 499, (undergraduate research) and service learning activities, e.g., BMS 300, and remunerated courses). Course/Combined Credit Hours Contact Hours # students TLE Equated TLEs

BMS 620-sp10 3 3 6 3x1.33 0.8 (20% of total for class)

BMS 521-sp10 4 9 23 3x1, then 3x0.67 5.01

BMS 622-sp10 4 6 3 3x1.33, then 3x0.67

0.601(10% of total for class)

BMS 494-sp10 1 1 14 1 1

BMS 494-sp10 1 1 11 1 1

BMS 730-sp10 1 1 12 1.33 1.33

BMS 528-sp10 2 2 6 2x1 2

BMS 628-sp10 2 2 1 2x1.33 0.44(16% of total for class)

Total 25 12.36

BMS 620-fa10 3 3 7 3x1.33 0.76

BMS 521-fa10 4 9 26 3x1, then 3x0.67 5.01

BMS 622-fa10 4 6 4 3x1.33, then 3x0.67

0.65

BMS 494-fa10 1 1 15 1 1

BMS 494-fa10 1 1 14 1 1

R.C.Garrad 11

BMS 730-fa10 1 1 15 1.33 1.33

Total 21 9.75

Course/Combined Credit Hours Contact Hours

# students TLE Equated TLEs

BMS 620-sp11 3 3 7 3x1.33 0.5 (12% of total for class)

BMS 520-sp11 3 3 1 3x1 0.05(0.6% of total of class)

BMS 521-sp11 4 9 27 3x1, then 3x0.67

5.01

BMS 622-sp11 4 6 1 3x1.33, then 3x0.67

0.1(0.6% of total for class)

BMS 494-sp11 1 1 15 1 1

BMS 730-sp11 1 1 17 1.33 1.33

BMS 535-sp11 2 2 2 2x1 0.1(14% of total class

BMS 635-sp11 2 2 12 2x1.33 2.66

Total 27 10.75

BMS 620-fa11 3 3 7 3x1.33 1(25% of total for class)

BMS 521-fa11 4 9 22 3x1, then 3x0.67

5.01

BMS 622-fa11 4 6 1 3x1.33, then 3x0.67


BMS 494-fa11 1 1 17 1 1

BMS 494-fa11 1 1 16 1 1

BMS 730-fa11 1 1 12 1.33 1.33

Total 21 9.54

Course/Combined Credit Hours Contact Hours # students TLE Equated TLEs


BMS 521-sp12 4 6 27 3x1, then 3x0.67 4.64(77% of total class)

BMS 622-sp12 4 6 1 3x1.33, then 3x0.67

0.14(2.8% of total for class)

BMS 494-sp12 1 1 17 1 1

BMS 524-sp12 3 4 10 2x1 then 2x0.67 3.34

BMS 730-sp12 1 1 12 1.33 1.33

BMS 535-sp12 2 2 3 2x1 0.75 (37.5% of class)

BMS 635-sp12 2 2 5 2x1.33 1.67(62.5% of class)

Total 17 13.67

BMS 620-fa12 3 3 7 3x1.33 0.7(18% of total for class)

R.C.Garrad 12

BMS 521-fa12 4 6 28 3x1, then 3x0.67 4.2(70% of class)

BMS 622-fa12 4 6 5 3x1.33, then 3x0.67


BMS 494-fa12 1 2 20 1 2

BMS 730-fa12 1 1 17 1.33 1.33

Total 12 8.98



BMS 521-sp13 4 3 29 3x1 2.35(78% of total class)


BMS 494-sp13 1 2 23 2 2

BMS 524-sp13 3 4 12 2x1 then 2x0.67 3.34

BMS 730-sp13 1 1 17 1.33 1.33

Total 17 9.89


BMS 521-fa13 4 3 31 3x1 2.8(70% of class)


BMS 494-fa13 1 2 21 2 2

BMS 730-fa13 1 1 17 1.33 1.33

In the fall of 2013 I was given 3 hours of release time for my involvement as chair of the Pre-medical ctte

Total 12 7.32





BMS 494-sp14 1 2 21 2 2

BMS 524-sp14 3 4 13 2x1 then 2x0.67 3.34

BMS 730-sp14 1 1 17 1.33 1.33

Total 16 19.46 9.87

BMS 521-fa14 4 6 31 3x1 then 3x0.67 4.44(89% of class)


BMS 494-fa14 1 2 16 2 2

BMS 730-fa14 1 1 11 1.33 1.33


R.C.Garrad 13

Total 12 12.34 8.23




BMS 494-sp15 1 2 33 2 2

BMS 524-sp15 3 4 18 2x1 then 2x0.67 3.34

BMS 730-sp15 1 1 11 1.33 1.33

Total 13 13.65 9.13

BMS 521-fa15 4 6 44 3x1 then 3x0.67 4.44(89% of class)


BMS 494-fa15 1 2 13 2 2

BMS 730-fa15 1 1 12 1.33 1.33


Total 12 11.77 8.23

1Completing workload for classes not assigned (including BMS 498 and 499, and service learning activities, e.g., BMS

300, and remunerated courses). For all courses taught, add a matrix below containing the following labeled columns: course, credit hrs., contact hrs., # students, TLEs, equated TLEs.


BMS 498-sp10 2 5 3 0.2 1

BMS 498-fa10 2 5 3 0.2 1

UHC 110-fa10 2 2 18 2 2

Total 4


BMS 498-sp11 2 5 2 0.2 1

BMS 498-fa11 2 5 1 0.2 1

UHC 110-fa11 2 2 18 2 2

R.C.Garrad 14

Total 4


BMS 498-sp12 2 5 2 0.2 1

BMS 798-sp12 1 5 1 0.2 1

BMS 798-sp12 2 7 1 0.2 1.4

BMS 499-sp12 1 1 1 1 1

BMS 799-sp12 3 5 1 0.2 1

Total 5.4

BMS 498-fa12 2 5 1 0.2 1

BMS 798-fa12 3 10 1 0.2 2

BMS 798-fa12 4 15 1 0.2 3

BMS 797-fa12 2 5 1 1 5

BMS 799-fa12 2 7 1 0.2 1.4

BMS 799-fa12 4 15 1 0.2 3

Total 15.4


BMS 498-sp13 2 5 2 0.2 1

BMS 797-sp13 1 5 1 0.2 1

BMS 798-sp13 2 7 1 0.2 1.4

BMS 499-sp13 1 1 1 1 1

Total 4.4

BMS 498-fa13 2 5 1 0.2 1

BMS 798-fa13 3 10 1 0.2 2

BMS 799-fa13 4 15 1 0.2 3

BMS 726-fa13 2 5 1 1 5

BMS 602-fa13 2 7 1 0.2 1.4

Total 12.4


BMS 498-sp14 2 5 1 0.2 1

BMS 602-sp14 2 7 1 0.2 1.4

Total 2.4

BMS 498-fa14 2 5 1 0.2 1

Total 17 0.6 1.0


BMS 498-sp15 3 5 3 0.2 1

R.C.Garrad 15

BMS 602-sp15 2 7 1 0.2 1.4

BMS 497-sp15 1 5 1 1 5

Total 17 7.4

BMS 498-fa15 2 5 2 0.2 1

BMS 797 3 5 1 1 5

BMS 798 3 5 1 0.2 1

UHC 398 1 5 2 1 5

Total 20 0.6 12

1Administering course/instructor evaluations (Student Assessment of Learning Gains standard battery of questions); receiving consistently acceptable (2.5 or above) SALG ratings or 3.0 or below on the CHHS Student Evaluation Form (average of all courses instructed).

Numerical summaries of student evaluations of teaching CHHS Student Eval Form

Class Sp10 Fa10 Mean

BMS

620

1.00 1.08 1.04

BMS

622

1.00

BMS

521

1.17 1.21 1.19

BMS

528

1.00 NT 1.00

UHC

110

NT 1.17 1.17

N/T not taught.

Numerical summaries of student evaluations of teaching, SP11 numbers represent ratings from the CHHS student evaluation

forms, FA11 numbers represent SALG ratings EXCEPT for UHC 110 where the numbers are generated from the honors

college evaluation sheet on a scale of 1-5 (1 being strongly disagree and 5 being strongly agree, the answers reflecting

effectiveness of the class, the honors college average score is 3.78)

Class Sp11 Fa11

BMS 620 1.01

BMS

521/620/622

1.11 4.06

UHC

110

NT 3.93

BMS

535/635

1.58

BMS 494 4.13

R.C.Garrad 16

N/T not taught.

Department adopted SALG evaluations from this point onward. These are lengthy evaluation forms. My scores in these

evaluations are consistently above 4.5 in all categories.

R.C.Garrad 17

Evaluation matrix for Teaching, Scholarship and Service since 2010

Ratings levels:-Exceptional, Commendable, Competent, Development needed, Unsatisfactory. These ratings are approved by the BMS

department, Reappointment, Promotion and Tenure Committee. The years when “commendable” rating were given reflect particularly

challenging years in terms of Teaching and Service.

Teaching Scholarship Service 2010 Exceptional Commendable Exceptional 2011 Exceptional Commendable Exceptional 2012 Exceptional Exceptional Exceptional 2013 Exceptional Commendable Exceptional 2014 Exceptional Exceptional Exceptional

Requirement for Promotion from Associate to Professor to Full Professor

1. Scholarship Criteria.

a. Primary or co-authorship of two refereed original research publications resulting

from work initiated while an Associate Professor at Missouri State University. If a

co-author, the applicant’s contributions must be substantial and thoroughly

documented.

I have published 4 articles since becoming a full Professor and have 2 further manuscripts submitted (see CV)

b. Authorship or co-authorship of four research presentations at regional, national,

or international meetings, at least three times as presenter, while an Associate

Professor at Missouri State.

I have been a part of seven presentations at local, regional and national meetings since becoming full Professor (see CV)

c. Demonstration of at least four primary effort indicators or their equivalents,

attained since promotion to Associate Professor.

See Below…two secondary indicators or three tertiary indicators are equivalent to a primary indicator.

Scholarship Indicators

1. Primary effort indicators include the following:

a. Publishing, as author or co-author, scholarship of discovery, application, or teaching/learning in refereed

journals. (Exceeded, see CV)

b. Writing or contributing a chapter or chapters to a discipline-related book published for external

dissemination.

c. Publishing scholarly reviews of discipline-related research in refereed journals. (Done, see CV)

d. Publishing a peer-reviewed technical report.

e. Obtaining funding, as the principal or co-principal investigator, for an externally funded grant or contract.

(Done, see CV)

1. Secondary effort indicators include the following:

R.C.Garrad 18

a. Writing ancillary text materials (study guides, test banks, etc.) to accompany published textbooks for

external dissemination.

b. Obtaining funding for intramural grants or projects as principal or co-principal investigator.

c. Submitting application, as the principal or co-principal investigator, for an externally-funded grant or

contract. (Done, see CV)

d. Presenting original peer-reviewed data at national or international meetings. (Exceeded, see CV)

e. Demonstrating a scholarly manuscript under revision, but not yet accepted for publication in a refereed

journal. (Exceeded, see CV)

f. The list of secondary effort indicators above is not exhaustive. Applicants may make a case for the

inclusion of additional appropriate secondary effort indicators that are not on this list.

2. Tertiary effort indicators include the following:

a. Publishing articles in non-refereed journals or popular magazines related to professional interest area.

b. Writing book reviews published on a regular basis in refereed journals.

c. Presenting scholarly activities in seminars within the department, college, university, or local community.

d. Submitting applications for intramural grants or projects as principal investigator.

e. Attending scholarly or scientific state, regional, or national programs, conferences, or conventions.

f. Receiving a University Award for excellence in research and scholarly activity.

g. Presenting original data at state or regional meetings. (Done, see CV)

h. Receiving additional formal training in a new research methodology, technique, or design.

Documents

CURRICULUM VITAE Richard C. Garrad