Curriculum Vitae September 2017 - University of …training.cvrc.virginia.edu/events/690resume.pdfCurriculum Vitae Daniel James Rader, M.D. September 2017 Office Address: Perelman

Curriculum Vitae Daniel James Rader, M.D.

September 2017 Office Address: Perelman School of Medicine University of Pennsylvania 11-125 Smilow Center for Translational Research 3400 Civic Center Blvd Philadelphia, PA 19104 Tel: 215/573-4176 Fax: 215/573-8606 E-mail address: [email protected] Education: 1981 B.A. Lehigh University, (summa cum laude) 1984 M.D. Medical College of Pennsylvania (summa cum laude) Postgraduate Training and Fellowship Appointments: 1984-1985 Internship, Internal Medicine, Yale-New Haven Hospital, New Haven, CT 1985-1987 Residency, Internal Medicine, Yale-New Haven Hospital, New Haven, CT 1987-1988 Chief Resident, Internal Medicine, Yale School of Medicine, New Haven, CT 1988-1991 Medical Staff Fellow, Molecular Disease Branch, National Heart, Lung, and

Blood Institute, National Institutes of Health, Bethesda, MD Academic Appointments: 1991-1993 Staff Scientist, Molecular Disease Branch, NHLBI, NIH 1994-2000 Assistant Professor of Medicine, University of Pennsylvania School of Medicine 2000-2005 Associate Professor of Medicine, University of Pennsylvania School of Medicine

2006-2014 Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor of Medicine

2006-present Professor of Pharmacology, University of Pennsylvania School of Medicine (Secondary)

2013-present Professor of Medicine in Genetics, University of Pennsylvania School of Medicine (Secondary)

2014-present Seymour Gray Professor of Molecular Medicine, University of Pennsylvania School of Medicine

Hospital and Administrative Appointments: 1994-present Director, Preventive Cardiovascular Medicine and Lipid Clinic University of Pennsylvania Health System 1996-2005 Associate Program Director, General Clinical Research Center University of Pennsylvania School of Medicine

1996-1998 Institutional Review Board, University of Pennsylvania 1998-2006 GCRC Advisory Committee, Children’s Hospital of Philadelphia 2002 Chair, Experimental Therapeutics Theme Group, Strategic Planning

Initiative, University of Pennsylvania School of Medicine 2002-2008 Faculty Advisory Committee, Office of Human Research, Univ. Penn

Daniel J. Rader, M.D. Page 2

2003-2012 Chair, Advisory Committee, Molecular Diagnostics and Genotyping Core, University of Pennsylvania School of Medicine

2005-present Associate Director, Institute for Translational Medicine and Therapeutics University of Pennsylvania School of Medicine 2005-2006 Program Director, General Clinical Research Center University of Pennsylvania School of Medicine 2006-2011 Director, Clinical and Translational Research Center Perelman School of Medicine at the University of Pennsylvania 2007-present Bridge Funding Program Committee, Perelman School of Medicine at the

University of Pennsylvania 2008-present Committee on Appointments and Promotions, Department of Medicine,

Perelman School of Medicine at the University of Pennsylvania 2009-present Scientific Director, Clinical and Translational Research, Cardivascular

Institute, Perelman School of Medicine at the University of Pennsylvania 2011-present Chief, Division of Translational Medicine and Human Genetics, Department

of Medicine, Perelman School of Medicine at the University of Pennsylvania 2013-present Director, PennMedicine BioBank, Perelman School of Medicine at the

University of Pennsylvania 2014-present Chair, Department of Genetics, Pereleman School of Medicine at the

Univeristy of Pennsylvania 2016-present Chief, Division of Human Genetics, Department of Pediatrics, Perelman

School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia

Awards and Honors:

1979 Phi Beta Kappa 1983 Alpha Omega Alpha 1984 Dean's Award, Medical College of Pennsylvania 1995 WW Smith Charitable Trust Awardee 1996 Outstanding Faculty Award, Department of Medicine 1997 Donald B. Martin Outstanding Teacher Award 1999 Election to American Society of Clinical Investigation (ASCI) 2000 Established Investigator, American Heart Association 2000 Burroughs Wellcome Fund Clinical Scientist Award in Translational

Researc 2002-present Listing in “Top Doctors of Philadelphia” (Philadelphia Magazine) 2002 Doris Duke Charitable Foundation Distinguished Clinical Investigator Award 2004 Chair, Gordon Conference on Lipid and Lipoprotein Metabolism


2005 Jeffrey M. Hoeg Award for Basic Science and Clinical Research, Arteriosclerosis, Thrombosis, and Vascular Biology Council of the American Heart Association

2005 8th Annual Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Research

2005 William Osler Patient Oriented Research Award, University of Pennsylvania School of Medicine

2005 Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor of Medicine, University of Pennsylvania School of Medicine

2005 Bristol Myers Squibb “Freedom to Discover” Unrestricted Cardiovascular Research Award

2007 International Atherosclerosis Society Distinguished Fellow 2007 Election to Association of American Physicians (AAP) 2007 Named Associate Editor, Journal of Clinical Investigation (JCI) 2009 Dewitt Goodman Lecture, Columbia University 2009 Bondy Lecture, Yale University 2009 MERIT (Merthod to Extend Research in Time) Award from the NIH-NHLBI 2010 Banting Lecture, University of Toronto 2011 Peter Kuo Lecture, University of Medicine and Dentistry of New Jersey 2011 Election to the National Academy of Medicine (NAM) 2012 American Heart Association’s Clinical Research Prize 2013 Chair, Gordon Conference on Atherosclerosis 2017 Award for Outstanding Work in Science as Related to Medicine, American

College of Physicians

National Scientific Committees and Peer Review: National American Heart Association Lipoproteins and Lipid Metabolism Research Study

Committee, Member, 1990-1994 American Heart Association Southeastern Pennsylvania Affiliate Grant Review Committee,

Reviewer, 1995-1997 Executive Committee, Arteriosclerosis Thrombosis and Vascular Biology Council, American Heart

Association, 1999-2002 General Clinical Research Center, Site Visitor on competing renewals, 1997-2005 Program Projects, NHLBI, NIH, Ad hoc reviewer, 1996-present Program Chair, Arteriosclerosis Thrombosis and Vascular Biology Council, American Heart

Association Scientific Sessions, November 2001 Vice-Chair, Gordon Conference on Lipid and Lipoprotein Metabolism, Meriden, New Hampshire,

June, 2002 Program Co-chair, AHA ATVB meeting, May 8-10, 2003 Chair, Gordon Conference on Lipid and Lipoprotein Metabolism, Meriden, New Hampshire, June,

2004 Chair, Research Committee, American Heart Association Pennsylvania-Delaware Affiliate, 2004-

2005 Scientific Advisory Board, Stanley Sarnoff Foundation for Cardiovascular Research, 2001-2008 Board of External Experts, National Heart Lung and Blood Institute, National Institutes of Health,

2008-present Board, Deuel Conference, 2010-present Chair, Deuel Conference, 2013 Co-Chair, Gordon Conference on Atherosclerosis, 2013


Editorial and Peer Review Activity:

1999-present Editorial Board, Trends in Molecular Medicine 2000-present Editorial Board, Arteriosclerosis, Thrombosis, and Vascular Biology 2001-present Editorial Board, American Journal of Physiology (Endocrinology and Metabolism) 2002-present Editorial Board, Circulation 2002-present Editorial Board, Circulation Research 2005-present Editorial Board, Journal of Lipid Research 2007-2012 Associate Editor, Journal of Clinical Investigation 2012-present Deputy Editor, Arteriosclerosis Thrombosis and Vascular Biology

Reviewer, American Journal of Cardiology Reviewer, Arteriosclerosis, Thrombosis, and Vascular Biology Reviewer, Atherosclerosis Reviewer, Biochemica Biophysica Acta--Lipid Metabolism Reviewer, Cell Metabolism Reviewer, Circulation Reviewer, Circulation Research Reviewer, Clinical Chemistry Reviewer, Diabetes Reviewer, Diabetes Care Reviewer, Journal of Clinical Investigation Reviewer, Journal of Lipid Research Reviewer, Metabolism Reviewer, Molecular and Cell Biology Reviewer, Nature Reviewer, Nature Cell Bioloby Reviewer, Nature Genetics Reviewer, Nature Medicine Reviewer, New England Journal of Medicine Reviewer, Proceedings of the National Academy of Sciences Reviewer, Science Reviewer, Science Translational Medicine

Teaching and Education 1. Outpatient Attending, Preventive Cardiovascular Medicine and Lipid Clinic; 1994-present 2. Lecturer, Medical Student Curriculum 2000, Cardiovascular Block, University of Pennsylvania

School of Medicine; 2-4 lectures per year; 1996-present. 3. Lecturer, Medical Student Curriculum 2000, Genetics Block, University of Pennsylvania School

of Medicine; 1 lecture per year; 2009-present. 4. Unit Coordinator, Molecular Basis of Gene Therapy, CAMB 610; 2 months per year; 1997-

present. 5. Lecturer, Introduction to Patient Oriented Research Course, 1999-2006 6. Lecturer, Clinical Investigator Toolbox Course, Department of Medicine 2006-present Active NIH and Foundation Grant Support (not including industry-sponsored research) Grant/sponsor Dates R37 HL055323 (Rader) 04/01/14-03/31/19 NHLBI "HDL Metabolism: Influence of Extracellular Lipases"


UL1TR 0000003 (FitzGerald) 07/01/06-06/30/21 NIH, NHGRI "Institutional Clinical and Translational Science Award" U01 HG006398 (Rader) 07/01/11-06/30/17 NIH, NHGRI “iPS-derived hepatocytes for interrogation of lipid phenotypes associated with GWAS lipid loci” R01 HL111398 (Rader) 01/01/12-11/30/16 NIH, NHLBI “Discovery and Validation of Novel Loci Associated with HDL Function” 1R01 HL111293 (Gelfand) 02/01/12-01/31/17 NIH, NHLBI “A trial to determine the effect of psoriasis treatment on cardiometabolic disease” R01 HL122843-01A1 (Saleheen/Rader) 02/01/2015-01/31/19 NIH/NHLBI “Molecular mechanisms linking the CXCL12 pathway to atherosclerosis” P01 HL059407 (Wilson) 07/01/15 – 06/30/20 NIH, NHLBI AAV Gene Therapy for Lipid Disorders ‘Project 2 – Optimizing Liver-Directed Gene Therapy for Inherited Dyslipidemia (Project Leader: Rader)” RF1 AG051550 (Kaddurah-Daouk/Kling) 09/30/15-08/31/20 NIH/NIA “Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias” R01 HL133502 (Rader) 07/01/16-06/30/20 NIH/NHLBI “Structure-Function Analysis of Triglyceride Regulators ApoC-III and ApoA-V Using Natural Variants” Selected Lectures by Invitation (since Jan 2005 only)

2005 Medical Grand Rounds, Washington University, St. Louis, MO Deuel Conference on Lipids, Dana Point, CA Research Symposium Keynote Address, Lankenau Hospital, Wynnewood, PA Himmelfarb Lectureship, Sinai Hospital of Baltimore, Baltimore, MD Keystone Symposium, Whistler, BC Cardiology Grand Rounds, Johns Hopkins Hospital, Baltimore, MD Endocrine Grand Rounds, Beth Israel Deaconess Medical Center, Boston, MA Gordon Research Conference on Atherosclerosis, Meriden, NH 2nd International Symposium on Triglycerides and HDL” – New York, NY Gill Heart Research Day, University of Kentucky, Lexington, KY Jefferson Kynett CV Conference – Thomas Jefferson University – Philadelphia, PA ACC Cardiovascular Symposium – NYC 2006


Rockefeller University Hospital – NYC Cardiology Grand Rounds, New York University Medical School – NYC Keystone Symposium – Keystone, CO American Diabetes Association Conference – Washington, DC Thomas Jefferson University Translational Symposium – Philadelphia, PA Temple University Lecture Series – Philadelphia, PA Gordon Conference on Lipoprotein Metabolism – Mt Holyoke, MA Metabolic Syndrome Symposium – Boston, MA National Lipid Association Masters Summit Conference – AHA Scientific Sessions – Chicago, IL AHA Scientific Sessions – Chicago, IL Cooper University Hospital – Camden, NJ 2007 Endocrinology Grand Rounds, Temple University Hospital – Philadelphia, PA ACC Scientific Sessions – New Orleans, LA Society for Vascular Medicine and Biology Annual Scientific Sessions – Baltimore, MD European Lipoprotein Club – Tutzing, Germany DALM Meeting – New York, NY Cardiology Grand Rounds, Yale University School of Medicine – New Haven, CT Gill Heart Institute, University of Kentucky – Lexington, KY ACC Cardiovascular Symposium – New York, NY 2008 Cardiology Grand Rounds, Massachusetts General Hospital – Boston, MA Albert Einstein College of Medicine – New York, NY Temple University School of Medicine – Philadelphia, PA Gordon Conference on Lipid and Lipoprotein Metabolism, Waterville Valley, NH Tufts Molecular Cardiology Research Institute, Woods Hole, MA Ottawa Heart Institute, Ottawa, Ontario Cardiology Grand Rounds, Montreal Heart Institute, Montreal, Quebec Cardiology Grand Rounds, McGill University, Montreal, Quebec Citywide Endocrinology Grand Rounds, University of Toronto, Toronto, Ontario Invited speaker, 10th Anniversary Scientific Meeting of the Doris Duke Charitable Foundation National Lipid Association, AHA Conference – New Orleans, LA 2009 Cardiology and Internal Medicine Grand Rounds, UT Southwestern, Dallas Keynote Speaker, Vanderbilt University Cardiovascular Research Day – Nashville, TN Cardiology Grand Rounds, Brigham & Women’s Hospital – Boston, MA Cardiology Grand Rounds, Boston Medical Center – Boston, MA Cardiometabolic Health Congress – Boston, MA Bondy Lecture, Medical Grand Rounds, Yale University – New Haven, CT Dewitt Goodman Lecture, Medical Grand Rounds, Columbia University, New York, NY 2010 Children’s Hospital Oakland Research Institute – Oakland, CA Cardiology Grand Rounds, Stanford University – Palo Alto, CA Drexel University College of Medicine – Philadelphia, PA Temple University School of Medicine – Philadelphia, PA Keystone Symposium – Banff, Canada Deuel Conference on Lipids – Dana Point, CA Banting Lecture, University of Toronto – Toronto, Canada


Gordon Research Conference – Waterville Valley, NH Accelerating Proof of Concept Conference – Philadelphia, PA Johns Hopkins University – Baltimore, MD Cardiometabolic Health Congress – Boston, MA AHA Symposium– Chicago, IL ACC/NYCVS Symposium – New York, NY 2011 NURSA Meeting – Bethesda, MD Medicine Grand Rounds, NYU – New York, NY ATVB Meeting – Chicago, IL BIDMC Cardiology Grand Rounds – Boston, MA St. Francis Hospital – Hartford, CT HDL Summit – New York, NY Gordon Conference – Newport, RI Keynote speaker, Karolinska Institute Cardiovascular Retreat Cardiology Grand Rounds, University of Massachusetts Robert Jeresaty Cardiovascular Symposium, Hartford, CT Guest Speaker, Ernst Klenk Symposium in Molecular Medicine – Cologne, Germany AHA Symposium– Orlando, FL Plenary Speaker, American College of Rheumatology - Chicago, IL 2012 Keystone Symposium – Santa Fe, NM Medicine Grand Rounds, Washington University – St. Louis, MO University of Michigan – Ann Arbor, MI Nature Colloquium on Human Genetics – Boston, MA Scandinavian Atherosclerosis Conference – Denmark Medicine Grand Rounds, Columbia University – New York, NY Mayo Clinic – Rochester, MN ADA Meeting – Philadelphia, PA Gordon Conference – Watervalley Hill, NH Drexel University College of Medicine - Philadelphia, PA AHA Symposium – Los Angeles, CA CVRC Symposium – University of Virginia Inflammation and Atherosclerosis Symposium – Munich, Germany 2013 Keystone Symposium – Lake Tahoe, CA Deuel Conference – Silverado, Napa, CA Cleveland Clinic – Cleveland, OH ATVB Meeting – Lake Buena Vista, FL NYU Symposium – New York City, NY University of Colorado – Denver, CO ASGCT 16th Annual Meeting – Salt Lake City, UT National Lipid Association Meeting – Las Vegas, NV New York Lipid Club Lecture Club – NYC, NY Atherosclerosis Gordon Conference – Stowe, VT British Atherosclerosis Society Autumn Meeting – Cambridge, UK Hartford Hospital CV Symposium – Hartford, CT CHOP Symposium – Philadelphia, PA CHOP Mid-Atlantic Micro/ncRNA Mini-Symposium – Philadelphia, PA


2014 Vascular Biology Seminar at Harvard – Boston, MA 2014 Caskey Lecture, University of South Carolina - Columbia, SC Medical University of South Carolina - Charleston, SC Deuel Conference - San Diego, CA IVB/MHI Symposium – University of North Carolina – Chapel Hill, NC AHA Heart Science Forum - Philadelphia, PA McGill University – Royal Victoria Hospital – Montreal, Canada Gordon Conference – Watervalley Hill, NH 2015 Diabetes and Metabolism Seminar – University of Washington – Seattle, WA ISA – Amsterdam, Netherlands Keystone Symposia – Copenhagen, Denmark John Hopkins CVD Research Retreat – Baltimore, MD Cardiac Regeneration Meeting – Venice, Italy Mendelian Randomization Conference – Bristol, England University of Leicester – Leicester, England 2016 Cardeza Foundation for Hematologic Research – Philadelphia, PA Harvard School of Public Health, Boston MA KROC lectureship, Univ of Alabama Birmingham Yale Endowed Lectureship - New Haven, CT ESAB Medical College of Wisconsin - Milwaukee, WI Gordon Conference - Waterville Valley, NH FH Summit – Dallas, TX AACC Meeting, Philadelphia, PA AHA Symposium– New Orleans, LA 2017 DE-CTR ACCEL Annual Meeting – Newark, DE BHF Cambridge CRE annual event – Cambridge, UK ATVB|PVD Meeting - Minneapolis, MN Arno Roscher Endowed Lecture – Seattle, WA International Summit on Atherothrombosis – Chieti, ITALY

Bibliography Peer-Reviewed Original Scientific Publications

1. Sparks CE, Rader DJ, Marsh JB. Metabolism of two forms of apolipoprotein B of VLDL by rat liver. J Lipid Res. 1983 Feb;24(2):156-66. PMID: 6833892

2. Schaeffer JR, Rader DJ, Gregg RE, Fairwell T, Zech LA, Kindt MR, Benson MD, Brewer HB Jr. In vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new approach to the study of mutant proteins in humans. Trans Assoc Am Physicians. 1990;103:187-94. PMID: 2132530

3. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr. Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. J Biol Chem. 1990 Jun 15;265(17):10061-4. PMID: 2351649


4. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr. Human plasma apolipoproteins A-IV-0 and A-IV-3: Molecular basis for two rare variants of apolipoprotein A-IV-1. J Biol Chem. 1990 Jul 25;265(21):12734-9. PMID: 1973689

5. Charnas LR, Bernardini I, Rader DJ, Hoeg JM, Gahl WA. Clinical and laboratory findings in the oculocerebrorenal sydrome of Lowe, with special reference to growth and renal function. N Engl J Med. 1991 May 9;324(19):1318-25. PMID: 2017228

6. Lohse P, Kindt MR, Rader DJ, Brewer HB Jr. Three genetic variants of human plasma apolipoprotein A-IV. J Biol Chem. 1991 Jul 25;266(21):13513-8. PMID: 1677358

7. Rader DJ, Castro G, Zech LA, Fruchart JC, Brewer HB Jr. Metabolism of apolipoprotein A-I in high density lipoprotein particles LpA-I and LpA-I,A-II. J Lipid Res. 1991 Nov;32(11):1849-59. PMID: 1770304

8. Novotny WF, Brown SG, Miletich JP, Rader DJ, Broze GJ Jr. Plasma antigen levels of the lipoprotein associated coagulation inhibitor in patient samples. Blood. 1991 Jul 15;78(2):387-93. PMID: 2070076

9. Rader DJ, Gregg RE, Meng MS, Schaefer JR, Zech LA, Benson MD, Brewer HB Jr. In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. J Lipid Res. 1992 May;33(5):755-63. PMID: 1619367

10. Lohse P, Rader DJ, Brewer HB Jr. Heterozygosity for apolipoprotein E-4Philadelphia(Glu13----Lys, Arg145----Cys) is associated with incomplete dominance of type III hyperlipoproteinemia. J Biol Chem. 1992 Jul 5;267(19):13642-6. PMID: 1352296

11. Schaefer JR, Rader DJ, Ikewaki K, Fairwell T, Zech LA, Kindt MR, Davignon J, Gregg RE, Brewer HB Jr. In vivo metabolism of apolipoprotein A-I in a patient with homozygous familial hypercholesterolemia. Arterioscler Thromb. 1992 Jul;12(7):843-8. PMID: 1616910

12. Mautner SL, Sanchez JA, Rader DJ, Mautner GC, Ferrans VJ, Fredrickson DS, Brewer HB Jr, Roberts WC. The heart in Tangier disease: Severe coronary atherosclerosis with near absence of high-density lipoprotein cholesterol. Am J Clin Pathol. 1992 Aug;98(2):191-8. PMID: 1380771

13. Reblin T, Rader DJ, Beisiegel U, Greten H, Brewer HB Jr. Correlation of apolipoprotein(a) Isoproteins with Lp(a) density and distribution in fasting plasma. Atherosclerosis. 1992 Jun;94(2-3):223-32. PMID: 1385958

14. Shibusawa Y, Ito Y, Ikewaki K, Rader DJ, Brewer HB Jr. Counter-current chromatography of lipoproteins with a polymer phase system using the cross-axis synchronous coil planet centrifuge. J Chromatogr. 1992 Apr 3;596(1):118-22. PMID: 1522174

15. Weiss JS, Rodrigues M, Kruth HS, Rajagopalan S, Rader DJ, Kachadoorian H. Panstromal Schnyder's Corneal Dystrophy. Ultrastructural and histochemical studies. Ophthalmology. 1992 Jul;99(7):1072-81. PMID: 1495786

16. Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay G, Rader DJ, Gregg RE. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science. 1992 Nov 6;258(5084):999-1001. PMID: 1439810

17. Benvenga S, Cahnmann HJ, Rader DJ, Kindt M, Robbins J. Thyroxine binding to the apolipoproteins of high-density lipoproteins HDL2 and HDL3. Endocrinology. 1992 Dec;131(6):2805-11. PMID: 1446618

18. Klein HG, Lohse P, Duverger N, Albers JJ, Rader DJ, Zech LA, Santamarina-Fojo S, Brewer HB Jr. Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn). J Lipid Res. 1993 Jan;34(1):49-58. PMID: 8445342

19. Rader DJ, Cain W, Zech LA, Usher D, Brewer HB Jr. Variation in Lp(a) concentrations among individuals with the same apo(a) isoform is determined by the rate of Lp(a) production. J Clin Invest. 1993 Feb;91(2):443-7. PMID: 8432853


20. Rader DJ, Schaefer JR, Lohse P, Verges B, Kindt M, Zech LA, Steinmetz A, Brewer HB Jr. Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein. J Clin Invest. 1993 Aug;92(2):1009-17. PMID: 8349786

21. Wanner C, Rader DJ, Bartens W, Kraemer J, Brewer HB Jr, Schollmeyer P, Wieland H. Elevated plasma lipoprotein(a) in patients with the nephrotic syndrome. Ann Intern Med. 1993 Aug 15;119(4):263-9. PMID: 8328733

22. Emmerich J, Verges B, Tauveron I, Rader DJ, Santamarina-Fojo S, Schaefer J, Ayault-Jarrier M, Thieblot P, Brewer HB Jr. Familial high density lipoprotein deficiency due to marked hypercatabolism of normal apolipoprotein A-I. Arterioscler Thromb. 1993 Sep;13(9):1299-306. PMID: 8364014

23. Sharp D, Blinderman L, Combs KA, Kienzle B, Ricci B, Wagner-Smith K, Gil CM, Turck CW, Bouma ME, Rader DJ, Aggerbeck LP, Gregg RE, Gordon DA, Wetterau JR. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinemia. Nature. 1993 Sep 2;365(6441):65-9. PMID: 8361539

24. Rader DJ, Schaefer JR, Lohse P, Ikewaki K, Thomas F, Harris WA, Zech LA, Dujovne CA, Brewer HB Jr. Increased production of apolipoprotein A-I associated with elevated levels of high density lipoproteins and apolipoprotein A-I in a patient with familial hyperalphalipoproteinemia. Metabolism. 1993 Nov;42(11):1429-34. PMID: 8231838

25. Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, Schaefer J, Ishikawa T, Fairwell T, Zech L, Nakamura H, Nagano M, Brewer HB Jr. Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency. J Clin Invest. 1993 Oct;92(4):1650-8. PMID: 8408618

26. Ikewaki K, Rader DJ, Schaefer J, Fairwell T, Zech LA, Brewer HB Jr. Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer labeling methods. J Lipid Res. 1993 Dec;34(12):2207-15. PMID: 8301239

27. Rader DJ, Ikewaki K, Duverger N, Feuerstein I, Zech LA, Connor W, Brewer HB Jr. Markedly decreased plasma high density lipoprotein levels without premature coronary atherosclerosis caused by rapid catabolism of apolipoproteins A-I and A-II. J Clin Invest. 1994 Jan;93(1):321-30. PMID: 8282802

28. Duchateau P, Rader DJ, Duverger N, Theret N, De Geitere C, Brewer HB Jr, Fruchart JC, Castro G. Tangier disease: isolation and characterization of LpA-I, LpA-I:A-II, LpA-II, and LpA-IV particles from plasma. Biochim Biophys Acta. 1993 Aug 4;1182(1):30-6. PMID: 8347683

29. Duverges N, Rader DJ, Duchateau P, Fruchart JC, Castro G, Brewer HB Jr. Biochemical characterization of the three major subclasses of lipoprotein A-I (LpA-I) preparatively isolated from human plasma. Biochemistry. 1993 Nov 23;32(46):12372-9. PMID: 8241125

30. Rader DJ, Ikewaki K, Duverger N, Schmidt H, Pritchard H, Frohlich J, Clerc M, Dumon MF, Fairwell T, Zech L, Santamarino-Fojo S, Brewer HB Jr. Markedly accelerated catabolism of apolipoprotein A-II and high density lipoproteins containing apoA-II in classic LCAT deficiency and fish-eye disease. J Clin Invest. Jan 1994; 93(1): 321–330. PMCID: PMC293770

31. Sack M, Rader DJ, Cannon RO III. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet. 1994 Jan 29;343(8892):269-70. PMID: 7905101

32. Usher DC, Swanson C, Rader DJ, Krämer J, Brewer HB Jr. A comparison of Lp(a) levels in fresh and frozen plasma using ELISAs with either anti-apo(a) or anti-apoB reporting antibodies. Chem Phys Lipids. 1994 Jan;67-68:243-8. PMID: 8187219

33. Rader DJ, Cain W, Ikewaki K, Talley G, Zech LA, Usher D, Brewer HB Jr. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate. J Clin Invest. 1994 Jun;93(6):2758-63. PMID: 8201014


34. Traber MG, Rader DJ, Acuff R, Brewer HB Jr., Kayden HJ. Discrimination between RRR- and all racemic-alpha-tocopherols labeled with deuterium by patients with abetalipoproteinemia. Atherosclerosis. 1994 Jul;108(1):27-37. PMID: 7980705

35. Bartens W, Rader DJ, Talley G, Brewer HB Jr. Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia. Atherosclerosis. 1994 Aug;108(2):149-7. PMID: 7980714

36. Duverger N, Rader DJ, Brewer HB Jr. Distribution of subclasses of human HDL containing apolipoprotein A-I without apolipoprotein A-II (LpA-I) in normolipidemic men and women. Arterioscler Thromb. 1994 Oct;14(10):1594-9. PMID: 7918309

37. Ikewaki K, Rader DJ, Zech LA, Brewer HB Jr. In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism. J Lipid Res. 1994 Oct;35(10):1809-19. PMID: 7852858

38. Benvenga S, Cahnmann HJ, Rader DJ, Kindt M, Facchiano A, Robbins J. Thyroid hormone binding to isolated human apolipoproteins A-II, C-I, C-II, and C-III: homology in thyroxine binding sites. Thyroid. 1994 Fall;4(3):261-7. PMID: 7833661

39. Verges B, Rader DJ, Schaefer J, Zech L, Kindt M, Fairwell T, Gambert P, Brewer HB Jr. In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope study. J Lipid Res. 1994 Dec;35(12):2280-91. PMID: 7897325

40. Gorin MB, Paul TO, Rader DJ. Angioid streaks associated with abetalipoproteinemia. Ophthalmic Genet. 1994 Sep-Dec;15(3-4):151-9. PMID: 7749670

41. Gilligan D, Sack M, Guetta V, Casino P, Quyyumi A, Rader DJ, Panza J, Cannon RO III. The effect of antioxidant vitamins on low-density lipoprotein oxidation and impaired endothelium-dependent vasodilatation in patients with hypercholesterolemia. J Am Coll Cardiol. 1994 Dec;24(7):1611-7. PMID: 7963105

42. Duverger N, Rader DJ, Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Nagano M, Nakamura H, Brewer HB Jr. Characterization of high-density apolipoprotein particles A-I and A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency. Eur J Biochem. 1995 Jan 15;227(1-2):123-9. PMID: 7851377

43. Skarlatos S, Duverger N, Rader DJ, Kruth H. Cholesterol efflux from human monocyte-derived macrophages in the presence of LpA-I:A-II. Biochim Biophys Acta. 1995 Jan 25;1270(1):19-25. PMID: 7827131

44. Rader DJ, Mann WA, Cain W, Kraft HG, Usher D, Zech LA, Hoeg JM, Davignon J, Lupien P, Grossman M, Wilson JM, Brewer HB Jr. The LDL receptor is not required for normal catabolism of Lp(a) in humans. J Clin Invest. 1995 Mar;95(3):1403-8. PMCID: PMC441483

45. Ikewaki K, Zech L, Kindt M, Brewer HB Jr, Rader DJ. Apolipoprotein A-II production rate is a major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and LpA-I:A-II in normolipidemic humans. Arterioscler Thromb Vasc Biol. 1995 Mar;15(3):306-12. PMID: 7749839

46. Ricci B, Sharp D, O'Rourke E, Kienzle B, Blinderman L, Gordon D, Smith-Monroy C, Robinson G, Gregg R, Rader DJ, Wetterau J. A 30 amino acid truncation of the microsomal triglyceride transfer protein large subunit disrupts its interaction with protein disulfide isomerase and causes abetalipoproteinemia. J Biol Chem. 1995 Jun 16;270(24):14281-5. PMID: 7782284

47. Bartens W, Rader DJ, Talley G, Kindt M, Brewer HB Jr. Lipoprotein(a) in patients with combined hyperlipidemia: effect of triglycerides. Eur J Clin Invest. 1995 Sep;25(9):647-53.

48. PMID: 7498237 49. Aguie G, Rader DJ, Clavey V, Traber M, Torpier G, Kayden H, Fruchart JC, Brewer HB Jr,

Castro G. Lipoproteins containing apolipoprotein B isolated from patients with abetalipoproteinemia: identification and characterization. Atherosclerosis. 1995 Dec;118(2):183-91. PMID: 8770313

50. Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Fairwell T, Zech L, Nagano M, Nakamura H, Brewer HB Jr, Rader DJ. Increased catabolic rate of low density lipoproteins in humans


with cholesteryl ester transfer protein deficiency. J Clin Invest. 1995 Sep;96(3):1573-81. PMID: 7657828

51. Grossman M, Rader DJ, Muller D, Kolansky D, Kozarsky K, Clark BJ, Stein E, Lupien P, Brewer HB Jr, Raper S, Wilson JM. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Nat Med. 1995 Nov;1(11):1148-54. PMID: 7584986

52. Jamieson D, Usher D, Rader DJ, Lavi E. Apolipoprotein(a) deposition in atherosclerotic plaques of cerebral vessels: a potential role for endothelial cells in lesion formation. Am J Pathol. 1995 Dec;147(6):1567-74. PMID: 7495281

53. Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ, Kolansky DM, Muller D, Wilson JM. Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia. Ann Surg. 1996 Feb;223(2):116-26. PMID: 8597504

54. Ikewaki K, Zech L, Brewer HB Jr, Rader DJ. ApoA-II kinetics in humans using endogenous labeling with stable isotopes: slower turnover of apoA-II compared with the exogenous radiotracer method. J Lipid Res. 1996 Feb;37(2):399-407. PMID: 9026537

55. Tsukamoto K, Smith P, Glick J, Rader DJ. Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in apoE deficient mice. J Clin Invest. 1997 Jul 1;100(1):107-14. PMCID: PMC508170.

56. Higazi A, Lavi E, Ulrich A, Jamieson D, Rader DJ, Usher D, Cain W, Ganz T, Cines D. Defensin stimulates the binding of lipoprotein(a) to human vascular endothelial and smooth muscle cells. Blood. 1997 Jun 15;89(12):4290-8. PMID: 9192751.

57. Webb NR, de Beer MC, van der Westhuyzen DR, Kindy MS, Banka CL, Tsukamoto K, Rader DJ, de Beer FC. Adenoviral vector-mediated over-expression of serum amyloid A in apoA-I deficient mice. J Lipid Res. 1997 Aug;38(8):1583-90. PMID: 9300780

58. Daugherty A, Pure E, Butteiger D, Chen S, Leferovich J, Roselaar S, Rader DJ. The effect of total lymphocyte deficiency on extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest. 1997 Sep 15;100(6):1575-80. PMCID: PMC508339

59. Tsukamoto K, Hiester K, Smith P, Usher D, Glick J, Rader DJ. Comparison of human apoA-I expression in mouse models of atherosclerosis after gene transfer using a second generation adenovirus. J Lipid Res. 1997 Sep;38(9):1869-76. PMID: 9323596.

60. Chang G, DeNofrio D, Desai S, Kelley MP, Rader DJ, Acker MA, Loh E. Lipoprotein(a) levels and heart transplantation atherosclerosis. Am Heart J. 1998 Aug;136(2):329-34. PMID: 9704698.

61. Kindy MS, Rader DJ. Reduction in amyloid A amyloid formation in apolipoprotein E-deficient mice. Am J Pathol. 1998 May;152(5):1387-95. PMCID: PMC1858574.

62. Pratico D, Tangirala RK, Rader DJ, Rokach J, FitzGerald GA. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in apoE deficient mice. Nat Med. 1998 Oct; 4 (10):1189-92. PMID: 9771755.

63. Traber M, Rader DJ, Acuff R, Ramakrishnan R, Brewer HB Jr, Kayden H. Vitamin E dose response studies in humans using deuterated RRR-alpha-tocopherol. Am J Clin Nutr. 1998 Oct;68(4):847-53. PMID: 9771861

64. Reilly MP, Pratico D, Delanty N, DiMinno G, Tremoli E, Rader DJ, Kapoor S, Lawson J, FitzGerald GA. Increased biosynthesis of distinct F2 isoprostanes in hypercholesterolemia. Circulation. 1998 Dec 22-29;98(25):2822-8. PMID: 9860782

65. Hosoai H, Webb NR, Glick J, Purdom MS, de Beer FC, Rader DJ. Expression of serum amyloid A protein in the absence of the acute phase response is not sufficient to reduce HDL cholesterol or apoA-I levels in mice. J Lipid Res. 1999 Apr;40(4):648-53. PMID: 10191288

66. Jaye M, Lynch KL, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ. A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet. 1999 Apr;21(4):424-8. PubMed PMID: 10192396

67. Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Witztum JL, Funk CD. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apoE-deficient mice. J Clin Invest. 1999 Jun;103(11):1597-604. PMCID: PMC408369


68. Tsukamoto K, Tangirala R, Chun SH, Pure’ E, Rader DJ. Rapid regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein E in apoE deficient mice. Arterio Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2162-70. PMID: 10479659

69. Tangirala R, Tsukamoto K, Chun SH, Usher D, Pure’ E, Rader DJ. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation. 1999 Oct 26;100(17):1816-22. PMID: 10534470

70. Barnhart KT. Freeman E. Grisso JA. Rader DJ. Sammel M. Kapoor S. Nestler JE. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab. 1999 Nov;84(11):3896-902. PMID: 10566625

71. Tietge U, Tsukamoto K, Maugeais C, Bakillah A, Hussain M, Rader DJ. Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo production of VLDL triglycerides and apolipoprotein B. J Lipid Res. 1999 Nov;40(11):2134-9. PMID: 10553017

72. Tietge UJF, Maugeais C, Cain W, Grass D, Glick J, deBeer FC, Rader DJ. Overexpression of secretory phospholipase A2 causes rapid catabolism and altered tissue uptake of HDL cholesteryl ester and apolipoprotein A-I. J Biol Chem. 2000 Apr 7;275(14):10077-84. PMID: 10744687

73. Tsukamoto K, Maugeais C, Glick JM, Rader DJ. Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE deficient mice. J Lipid Res. 2000 Feb;41(2):253-9. PMID: 10681409

74. Tsukamoto K, Tangirala RK, Chun S, Usher D, Pure’ E, Rader DJ. Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis in LDL receptor deficient mice. Mol Ther. 2000 Feb;1(2):189-94. PMID: 10933930.

75. Kozarsky KF, Donahee MH, Glick JM, Krieger M, Rader DJ. Hepatic overexpression of the HDL receptor SR-BI inhibits atherosclerosis despite reducing HDL cholesterol levels in mice. Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):721-7. PMID: 10712397

76. DeNofrio D, Desai S, Rader DJ, Chang G, Kelly MP, Acker MA, Loh E. Changes in lipoprotein(a) concentrations following orthotopic heart transplantation. Am Heart J. 2000 Apr;139(4):729-33. PMID: 10740159

77. Kawashiri M, Maugeais C, Rader DJ. High density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis. Curr Atheroscler Rep. 2000 Sep;2(5):363-72. PMID: 11122767

78. Chen SJ, Rader DJ, Tazelaar J, Kawashiri M, Gao GP, Wilson JM. Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expression VLDL receptor. Mol Ther. 2000 Sep;2(3):256-61. PubMed PMID: 10985956

79. Maugeais C, Tietge UJF, Tsukamoto K, Glick JM, Rader DJ. Hepatic apoE expression promotes VLDL-apoB production in mice. J Lipid Res. 2000 Oct;41(10):1673-9. PMID: 11013310

80. Higazi AA, Nassar T, Ganz T, Rader DJ, Udassin R, Bdeir K, Hiss E, Sachais BS, Williams KJ, Leitersdorf E, Cines DB. The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis. Blood. 2000 Aug 15;96(4):1393-8. PMID: 10942383.

81. Detmers PA, Hernandez M, Mudgett J, Hassing H, Burton C, Mundt S, Chun S, Fletcher D, Card DJ, Lisnock JM, Weikel R, Bergstrom JD, Shevell DE, Hermanowski-Vosatka A, Sparrow C, Chao YS, Rader DJ, Wright SD, Pure E. Deficiency in inducible nitric oxide synthase (iNOS) results in reduced atherosclerosis in apoE-deficient mice. J Immunol. 2000 Sep 15;165(6):3430-5. PMID: 10975863.


82. Tangirala RK, Pratico D, FitzGerald GA, Chun S, Tsukamoto K, Maugeais C, Usher DC, Pure’ E, Rader DJ. Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem. 2001 Jan 5;276(1):261-6. PMID: 11024044

83. Tietge UJF, Sun G, Czarnecki S, Yu QC, Lohse P, Du H, Grabowski GA, Glick JM, Rader DJ. Phenotypic correction of lipid storage and growth arrest in Wolman disease fibroblasts by gene transfer of lysosomal acid lipase. Hum Gene Ther. 2001 Feb 10;12(3):279-89. PMID: 11177564.

84. Wolfe ML, Vartanian SF, Ross JL, Bansavich LL, Mohler ER III, Meagher E, Friedrich CA, Rader DJ. Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia. Am J Cardiol. 2001 Feb 15;87(4):476-9, A7. PMID: 11179541

85. Kawashiri M, Zhang Y, Usher D, Reilly M, Pure’ E, Rader DJ. Effects of co-expression of the LDL receptor on cholesterol metabolism and atherosclerosis in LDLreceptor-deficient mice. J Lipid Res. 2001 Jun;42(6):943-50. PMID: 11369802.

86. Valdes AM, Wolfe M, Tate HC, Rut A, Rader DJ. Association of traditional risk factors with coronary calcification in persons with a family history of premature coronary heart disease: the Study of the Inherited Risk of Coronary Atherosclerosis. J Investig Med. 2001 Jul;49(4):353-61. PMID: 11478412.

87. Cyrus T, Pratico D, Zhao L, Witztum J, Rader DJ, Rokach J, FitzGerald G, Funk C. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice. Circulation. 2001 May 8;103(18):2277-82. PMID: 11342477

88. Cuff CA, Kothapalli D, Azonobi I, Chun S, Zhang Y, Belkin R, Yeh C, Secreto A, Assosian RK, Rader DJ, Pure E. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and activation of vascular cells. J Clin Invest. 2001 Oct;108(7):1031-40. PMCID: PMC200948

89. Snyder PJ, Peachey H, Berlin JA, Rader DJ, Usher D, Loh L, Hannoush P, Dlewati A, Holmes JH, Santanna J, Strom BL. Effect of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age. Am J Med. 2001 Sep;111(4):255-60. PMID: 11566454

90. Grundy SM, D’Agostino RB, Mosca L, Burke GL, Wilson PWF, Rader DJ, Cleeman JI, Roccella EJ, Cutler JA, Friedman LM. Cardiovascular risk assessment based on US cohort studies. 2001 Jul 24;104(4):491-6. PubMed PMID: 11468215

91. Millar JS, Maugeais C, Fuki IV, Rader DJ. Normal production rate of apolipoprotein B in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):989-94. PMID: 12067909.

92. McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ. Characterization of the lipolytic activity of endothelial lipase. J Lipid Res. 2002 Jun;43(6):921-9. PMID: 12032167

93. Tietge UJF, Maugeais C, Lund-Katz S, Grass D, deBeer FC, Rader DJ. Human secretory phospholipase A2 (sPLA2) mediates decreased plasma levels of HDL-cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1213-8. PubMed PMID: 12117740

94. Zhao L, Cuff CA, Moss E, Wille U, Cyrus T, Klein EA, Pratico D, Rader DJ, Hunter CA, Pure E, Funk CD. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. J Biol Chem. 2002 Sep 20;277(38):35350-6. PMID: 12122008

95. Jin W, Broedl U, Monajemi H, Glick JM, Rader DJ. Lipase H, a new member of the triglyceride lipase gene family synthesized in the intestine. Genomics. 2002

96. Sep;80(3):268-73. PubMed PMID: 12213196 97. deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ. Identification of genetic

variants in endothelial lipase in persons with elevated high sensity lipoprotein cholesterol. Circulation. 2002 Sep 10;106(11):1321-6. PubMed PMID: 12221047


98. Cuchel M, Wolfe ML, DeLemos AS, Rader DJ. The frequency of the cholesteryl ester transfer protein – TaqI B2 allele is lower in African Americans than in Caucasians. Atherosclerosis. 2002 Jul;163(1):169-74. PMID: 12048136.

99. Kawashiri M, Zhang Y, Puré E, Rader DJ. Combined effects of cholesterol reduction and apolipoprotein A-I expression on atherosclerosis in LDL receptor mice. Atherosclerosis. 2002 Nov;165(1):15-22. PubMed PMID: 12208466

100. Valdes AM, Wolfe ML, O’Brien EJ, Spurr NK, Gefter W, Rut A, Groot PHE, Rader DJ. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1924-8. PMID: 12426226.

101. Yu YH, Zhang Y, Oelkers P, Sturley SL, Rader DJ, Ginsberg HN. Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes. J Biol Chem. 2002 Dec 27;277(52):50876-84. PMID: 12407108

102. Wolfe ML, Iqbal N, Gefter W, Mohler ER, Rader DJ, Reilly M. Coronary artery calcification at electron beam CT is increased in asymptomatic type 2 diabetics independent of traditional risk factors. J Cardiovasc Risk. 2002 Dec;9(6):369-76. PubMed PMID: 12478207

103. Ikewaki K, Zech LA, Brewer HB Jr, Rader DJ. Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects. J Lab Clin Med. 2002 Nov;140(5):369-74. PubMed PMID: 12434139

104. Jin W, Millar JS, Broedl U, Glick JM, Rader DJ. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest. 2003 Feb;111(3):357-62. PMCID: PMC151853

105. Jin W, Gwo-Shing S, Marchadier D, Octtavani E, Glick JM, Rader DJ. Endothelial cells secrete triglyceride lipase and phospholipase activities due to endothelial lipase in response to inflammatory cytokines. Circ Res. 2003 Apr 4;92(6):644-50. PMID: 12609972

106. Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2730-5. PMCID: PMC151409

107. Tietge UJF, Maugeais C, Cain W, Rader DJ. Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2. Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E403-11. PMID: 12637261

108. Foster GD, Wyatt HR, Hill J, McGuckin BG, Brill C, Mohammed BS, Szapary P, Rader DJ, Edman JS, Klein S. A multicenter, randomized, controlled trial of a low-carbohydrate diet for obesity. N Engl J Med. 2003 May 22;348(21):2082-90. PubMed PMID: 12761365

109. Tietge UJF, Kozarsky KF, Donahee MH, Rader DJ. A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver. J Gene Med. 2003 Jul;5(7):567-75. PubMed PMID: 12825196.

110. Rashid S, Trinh DK, Uffelman KD, Cohn JS, Rader DJ, Lewis GF. Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native HDL apolipoprotein A-I. Circulation. 2003 Jun 24;107(24):3066-72. PubMed PMID: 12796142.

111. Kothapalli D, Stewart SA, Smyth EM, Azonobi I, Rader DJ, Puré E, Assoian RK. Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin A gene expression. Mol Pharmacol. 2003 Aug;64(2):249-58. PMID: 12869629

112. Szapary PO, Wolfe ML, Bloedon LT, Cucchiaria AJ, DerMarderosian AH, Cirigliano MD, Rader DJ. Guggulipid for the treatment of hypercholesterolemia: a randomized, controlled trial. JAMA. 2003 Aug 13;290(6):765-72. PubMed PMID: 12915429.

113. Zhang Y, Zanotti I, Reilly M, Glick JM, Rothblat GH, Rader DJ. Overexpression of apoA-I promotes reverse transport of cholesterol from macrophages to feces. Circulation. 2003 Aug 12;108(6):661-3. PubMed PMID: 12900335.


114. Reilly MP, Wolfe ML, Localico AR, Rader DJ. C-reactive protein and coronary artery calcification: the study of inherited risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1851-6. PubMed PMID: 12933535.

115. Maugeais C, Tietge UJF, Broedl UC, Marchadier D, Cain W, McCoy MG, Lund-Katz S, Glick JM, Rader DJ. Dose-dependent acceleration of HDL catabolism by endothelial lipase. Circulation. 2003 Oct 28;108(17):2121-6. PubMed PMID: 14517167.

116. Fuki IV, Blanchard N, Jin W, Marchadier D, Millar JS, Glick JM, Rader DR. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via HSPG-mediated pathway. J Biol Chem. 2003 Sep 5;278(36):34331-8. PubMed PMID: 12810721.

117. Duong M, Psaltis M, Rader DJ, Marchadier D, Barter PJ, Rye KA. Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids. Biochemistry. 2003 Nov 25;42(46):13778-85. PubMed PMID: 14622025.

118. Moore RE, Kawashiri MA, Kitajima K, Secreto A, Millar JS, Pratico D, Rader DJ. Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor. Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1914-20. PubMed PMID: 12933536.

119. Broedl UC, Maugeais C, Marchadier D, Glick JM, Rader DJ. Effects of nonlipolytic ligand function of endothelial lipase on high-density lipoprotein metabolism in vivo. J Biol Chem. 2003 Oct 17;278(42):40688-93. PubMed PMID: 12909635.

120. Cuchel M, Rader DJ. Genetics of increased HDL cholesterol levels: insights into the relationship between HDL metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1710-2. PubMed PMID: 14555638.

121. Caiazza D, Jahangiri A, Rader DJ, Marchadier D, Rye KA. Apolipoproteins regulate the kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins. Biochemistry. 2004 Sep 21;43(37):11898-905. PMID: 15362876.

122. Seshadri P, Iqbal N, Stern L, Williams M, Chicano KL, Daily DA, McGrory J, Gracely EJ, Rader DJ, Samaha FF. A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity. Am J Med. 2004 Sep 15;117(6):398-405. PMID: 15380496.

123. Wolfe ML, Rader DJ. Cholesteryl ester transfer protein and coronary artery disease: an observation with therapeutic implications. Circulation. 2004 Sep 14;110(11):1338-40. PubMed PMID: 15364817.

124. Zhao L, Moos MP, Grabner R, Pedrono F, Fan J, Kaiser B, John N, Schmidt S, Spanbroek R, Lotzer K, Huang L, Cui J, Rader DJ, Evans JF, Habenicht AJ, Funk CD. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med. 2004 Sep;10(9):966-73. PubMed PMID: 15322539.

125. Reilly MP, Wolfe ML, Rhodes T, Girman C, Mehta N, Rader DJ. Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis. Circulation. 2004 Aug 17;110(7):803-9. PubMed PMID: 15289378.

126. Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Kimmel SE. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab. 2004 Aug;89(8):3872-8. PubMed PMID: 15292320.

127. Ikewaki K, Cain W, Thomas F, Shamburek R, Zech LA, Usher D, Brewer HB Jr, Rader DJ. Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency. J Lipid Res. 2004 Jul;45(7):1302-11. PubMed PMID: 15102883.

128. Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, Marchadier D, Glick JM, Rader DJ. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res. 2004 Jun 25;94(12):1554-61. PubMed PMID: 15117821.


129. Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004 Apr 8;350(15):1505-15. PubMed PMID: 15071125.

130. Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004 Apr 8;350(15):1495-504. Erratum in: N Engl J Med. 2006 Feb 16;354(7):778. PubMed PMID: 15007110.

131. Reilly MP, Wolfe ML, Localio AR, Rader DJ. Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach. Atherosclerosis. 2004 Mar;173(1):69-78. PubMed PMID: 15177125.

132. Kothapalli D, Fuki I, Ali K, Stewart SA, Zhao L, Yahil R, Kwiatkowski D, Hawthorne EA, FitzGerald GA, Phillips MC, Lund-Katz S, Pure E, Rader DJ, Assoian RK. Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation. J Clin Invest. 2004 Feb;113(4):609-18. PubMed PMID: 14966570; PubMed Central PMCID: PMC338263.

133. Yancey PG, Kawashiri MA, Moore R, Glick JM, Williams DL, Connelly MA, Rader DJ, Rothblat GH. In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux. J Lipid Res. 2004 Feb;45(2):337-46. PubMed PMID: 14594995.

134. Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA. COX-2-derived prostacyclin confers atheroprotection on female mice. Science. 2004 Dec 10;306(5703):1954-7. PMID: 15550624

135. Broedl UC, Jin W, Fuki IV, Glick JM, Rader DJ. Structural basis of endothelial lipase tropism for HDL. FASEB J. 2004 Dec;18(15):1891-3. PMID: 15456739

136. Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chretien M, Prat A, Seidah NG. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low-density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem. 2004 Nov 19;279(47):48865-75. PubMed PMID: 15358785.

137. Miller GC, Long CJ, Bojilova ED, Marchadier D, Badellino KO, Blanchard N, Fuki IV, Glick JM, Rader DJ. Role of N-linked glycosylation in the secretion and activity of endothelial lipase. J Lipid Res. 2004 Nov;45(11):2080-7. PubMed PMID: 15342690.

138. PMCID: PMC529430. 139. Reilly MP, Wolfe ML, Dykhouse J, Reddy K, Localio AR, Rader DJ. Intercellular adhesion

molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels. J Investig Med. 2004 Dec;52(8):515-22. PubMed PMID: 15682683.

140. Bastone L, Reilly M, Rader DJ, Foulkes AS. MDR and PRP: a comparison of methods for high-order genotype-phenotype associations. Hum Hered. 2004;58(2):82-92. PubMed PMID: 15711088.

141. Jahangiri A, Rader DJ, Marchadier D, Curtiss LK, Bonnet DJ, Rye KA. Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I. J Lipid Res. 2005 May;46(5):896-903. PubMed PMID: 15687350.

142. Foulkes AS, Reilly M, Zhou L, Wolfe M, Rader DJ. Mixed modelling to characterize genotype-phenotype associations. Stat Med. 2005 Mar 15;24(5):775-89. PubMed PMID: 15696502.

143. Millar JS, Maugeais C, Ikewaki K, Kolansky DM, Barrett PH, Budreck EC, Boston RC, Tada N, Mochizuki S, Defesche JC, Wilson JM, Rader DJ. Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):560-5. PubMed PMID: 15637307.

144. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005 Feb 22;111(7):932-9. PMID: 15710760

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15682683&query_hl=4



145. Ky B, Rader DJ. The effects of statin therapy on plasma markers of inflammation in patients without vascular disease. Clin Cardiol. 2005 Feb;28(2):67-70. PMID: 15757075

146. Kratky D, Zimmermann R, Wagner EM, Strauss JG, Jin W, Kostner GM, Haemmerle G, Rader DJ, Zechner R. Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. J Clin Invest. 2005 Jan;115(1):161-7. PMCID: PMC539186

147. Sovic A, Panzenboeck U, Wintersperger A, Kratzer I, Hammer A, Levak-Frank S, Frank S, Rader DJ, Malle M, Sattler W. Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood–brain barrier. J Neurochem. 2005 Jul;94(1):109-19. PubMed PMID: 15953354

148. Sachais BS, Katz J, Ross J, Rader DJ. Long-term effects of LDL apheresis in patients with severe hypercholesterolemia. J Clin Apher. 2005 Dec;20(4):252-5. PMID: 15880364

149. Rosas SE, Mensah K, Weinstein RB, Bellamy SL, Rader DJ. Coronary artery calcification in renal transplant recipients. Am J Transplant. 2005 Aug;5(8):1942-7. PubMed PMID: 15996243.

150. Brousseau ME, Diffenderfer MR, Millar JS, Nartsupha C, Asztalos BF, Welty FK, Wolfe ML, Rudling M, Bjorkhem I, Angelin B, Mancuso JP, Digenio AG, Rader DJ, Schaefer EJ. Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterioscler Thromb Vasc Biol. 2005 May;25(5):1057-64. PubMed Central PMCID: PMC3229922

151. Lehrke M, Lebherz C, Millington SC, Guan HP, Millar J, Rader DJ, Wilson JM, Lazar MA. Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. Cell Metab. 2005 May;1(5):297-308. PubMed PMID: 16054077.

152. Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein covertases are responsible for proteolysis and inactivation of endothelial lipase. J Biol Chem. 2005 Nov 4;280(44):36551-9. PubMed PMID: 16109723.

153. Cain WJ, Millar JS, Himebauch AS, Tietge UJ, Maugeais C, Usher D, Rader DJ. Lipoprotein(a) is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein(a). J Lipid Res. 2005 Dec;46(12):2681-91. PubMed PMID: 16150825.

154. Moore RE, Navab M, Millar JS, Zimetti F, Hama S, Rothblat GH, Rader DJ. Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circ Res. 2005 Oct 14;97(8):763-71. PubMed PMID: 16151025

155. Reilly M, Foulkes AS, Wolfe ML, Rader DJ. Higher-order lipase gene association with plasma triglycerides. J Lipid Res. 2005 Sep;46(9):1914-22. PubMed PMID: 15961789.

156. Madaio MP, Ahima RS, Meade R, Rader DJ, Mendoza A, Peng M, Tomaszewski JE, Hancock WW, Gasser DL. Glomerular and Tubular Epithelial Defects in kd/kd Mice Lead to Progressive Renal Failure. Am J Nephrol. 2005 Nov-Dec;25(6):604-10. PubMed Central PMCID: PMC2254218

157. Zhang Y, Da Silva JR, Reilly M, Billheimer JT, Rothblat GH, Rader DJ. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest. 2005 Oct;115(10):2870-4. PubMed Central PMCID: PMC1236682

158. Ali K, Middleton M, Pure E, Rader DJ. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ Res. 2005 Oct 28;97(9):922-7. PMID: 16179587

159. Broedl UC, Jin W, Marchadier D, Secreto A, Rader DJ. Tissue-specific expression pattern of human endothelial lipase in transgenic mice. Atherosclerosis. 2005 Aug;181(2):271-4. PubMed PMID: 16039280

160. Millar JS, Cromley DA, McCoy MG, Rader DJ, Billheimer JT. Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res. 2005 Sep;46(9):2023-8. PubMed PMID: 15995182









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161. Li Z, Qiao H, Lebherz C, Choi SR, Zhou X, Gao G, Kung HF, Rader DJ, Wilson JM, Glickson JD and Zhou R. Creatine Kinase, a Magnetic Resonance Detectable Marker Gene for Quantification of Liver-Directed Gene Transfer. Hum Gene Ther. 2005 Dec;16(12):1429-38. PubMed PMID: 16390274

162. Zhao L, Pratico D, Rader DJ, Funk CD. 12/15-Lipoxygenase gene disruption and Vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway. Prostaglandins Other Lipid Mediat. 2005 Dec;78(1-4):185-93. PubMed PMID: 16303615

163. Kitajima K, Marchadier DH, Burstein H, Rader DJ. Persistent liver expression of murine apoA-l using vectors based on adeno-associated viral vectors serotypes 5 and 1. Atherosclerosis. 2006 May;186(1):65-73. PubMed PMID: 16099465

164. Helgadottir A, Manolescu A, Helgason A, Thorleifsson G, Thorsteinsdottir U, Gudbjartsson DF, Gretarsdottir S, Magnusson KP, Gudmundsson G, Hicks A, Jonsson T, Grant SFA, Sainz J, O’Brien SJ, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Levey AI, Abramson JL, Reilly MP, Vaccarino V, Wolfe ML, Gudnason V, Quyyumi AA, Topol EJ, Rader DJ, Thorgeirsson G, Gulcher JR, Hakonarson H, Kong A, Stefansson K. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet. 2006 Jan;38(1):68-74. PMID: 16282974

165. Naik SU, Wang X, Da Silva JS, Jaye M, Macphee CH, Reilly MP, Billheimer, JT, Rothblat GH, Rader DJ. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation. 2006 Jan 3;113(1):90-7. PubMed PMID: 16365197

166. Seetharam D, Chieko M, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW. HDL promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res. 2006 Jan 6;98(1):63-72. PubMed PMID: 16339487

167. Szapary PO, Bloedon LT, Samaha FF, Duffy D, Wolfe ML, Soffer D, Reilly MP, Chittams J, Rader DJ. Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome. Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):182-8. PubMed PMID: 16284192

168. Samaha FF, Szapary PO, Iqbal N, Williams MM, Bloedon LT, Kochar A, Wolfe ML, Rader DJ. Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):624-30. PubMed PMID: 16357312

169. Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med. 2006 Feb;3(2):e22. PubMed Central PMCID: PMC1316064.

170. Millar JS, Brousseau ME, Diffenderfer MR, Barrett PH, Welty FK, Faruqi A, Wolfe, ML, Nartsupha C, Digenio AG, Mancuso JP, Dolnikowski GG, Schaefer EJ, Rader DJ. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans. Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1350-6. PubMed PMID: 16574893

171. Majdalawieh A, Zhang L, Fuki IV, Rader DJ, Ro HS. Adipocyte enhancer-binding 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2346-51. PubMed Central PMCID: PMC1413702

172. Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leucocyte adhesion. Circ Res. 2006 Mar 3;98(4):490-8. PubMed PMID: 16439686.

173. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir












U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006 Mar;38(3):320-3. PubMed PMID: 16415884

174. Griffon N, Budreck EC, Long CJ, Broedl UC, Marchadier DH, Glick JM, Rader DJ. Substrate specificity of lipoprotein lipase and endothelial lipase: studies of lid chimeras. J Lipid Res. 2006 Aug;47(8):1803-11. PubMed PMID: 16682746

175. Kitajima K, Marchadier DH, Miller GC, Gao GP, Wilson JM, Rader DJ. Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1852-7. PubMed PMID: 16763161

176. Paradis ME, Badellino KO, Rader DJ, Tchernof A, Richard C, Luu-The V, Deshaies Y, Bergeron J, Archer WR, Couture P, Bergeron N, Lamarche B. Visceral adiposity and endothelial lipase. J Clin Endocrinol Metab. 2006 Sep;91(9):3538-43. PubMed PMID: 16772345

177. Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV Jr, Rader DJ. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. J Lipid Res. 2006 Oct;47(10):2297-305. PubMed PMID: 16877777

178. Broedl UC, Jin W, Fuki IV, Millar JS, Rader DJ. Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II. Lipid Res. 2006 Oct;47(10):2191-7. PubMed PMID: 16877778

179. Paradis ME, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N, Lamarche B. Endothelial lipase is associated with inflammation in humans. J Lipid Res. 2006 Dec;47(12):2808-13. PubMed PMID: 16980590

180. Cuchel M, Bloedon LT, Szapary PO, Kolansky DM, Wolfe ML, Sarkis A, Millar JS, Ikewaki K, Siegelman ES, Gregg RE, Rader DJ. Inhibition of microsomal triglyceride transfer protein in homozygous familial hypercholesterolemia. N Engl J Med. 2007 Jan 11;356(2):148-56. PubMed PMID: 17215532

181. Helgason A, Palsson S, Thorleifsson G, Grant SF, Emilsson V, Gunnarsdottir S, Adeyemo A, Chen Y, Chen G, Reynisdottir I, Benediktsson R, Hinney A, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Schafer H, Faruque M, Doumatey A, Zhou J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Sigurdsson G, Hebebrand J, Pedersen O, Thorsteinsdottir U, Gulcher JR, Kong A, Rotimi C, Stefansson K. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet. 2007 Feb;39(2):218-25. PubMed PMID: 17206141

182. Lehrke M, Millington SC, Lefterova M, Cumaranatunge RG, Szapary P, Wilensky R, Rader DJ, Lazar MA, Reilly MP. CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol. 2007 Jan 30;49(4):442-9. PubMed PMID: 17258089

183. Zhao L, Hall JA, Levenkova N, Lee E, Middleton MK, Zukas AM, Rader DJ, Rux JJ, Pure E. CD44 regulates vascular gene expression in a proatherogenic environment. Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):886-92. PubMed PMID: 17272751

184. Wang X, Jin W, Rader DJ. Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production. Circ Res. 2007 Apr 13;100(7):1008-15. PubMed PMID: 17347473.

185. Pellizzon MA, Billheimer JT, Bloedon LT, Szapary PO, Rader DJ. Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models. J Am Coll Nutr. 2007 Feb;26(1):66-75. PubMed PMID: 17353585

186. Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ. Hepatic proprotein convertases modulate HDL metabolism Cell Metab. 2007 Aug;6(2):129-36. PubMed Central PMCID: PMC2565575.

187. Wang X, Collins HL, Ranalletta M, Fuki IV, Billheimer JT, Rothblat GH, Tall AR, Rader DJ. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol


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transport in vivo. J Clin Invest. 2007 Aug;117(8):2216-24. PubMed Central PMCID: PMC1924499

188. Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafnar T, Gudbjartsson D, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S, Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kimber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC, Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben KK, Graif T, Cashy J, Suarez BK, van Vierssen Trip O, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007 Aug;39(8):977-83. PubMed PMID: 17603485

189. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007 Jun 8;316(5830):1491-3. PubMed PMID: 17478679.

190. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007 Jun;39(6):770-5. PubMed PMID: 17460697

191. Rosas S, Joffe M, Wolfe M, Brayman K, Rader DJ. Effects of Renal Replacement Therapy on Plasma Lipoprotein(a) Levels. Am J Nephrol. 2008;28(3):361-5. PubMed Central PMCID: PMC2786011.

192. Adorni MP, Zimetti F, Billheimer JT, Wang N, Rader DJ, Phillips MC, Rothblat GH. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res. 2007 Nov;48(11):2453-62. PubMed PMID: 17761631

193. Parastatidis I, Thomson L, Fries DM, Moore RE, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, Ischiropoulos H. Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice. Circ Res. 2007 Aug 17;101(4):368-76. PubMed PMID: 17615369

194. Tanigawa H, Billheimer JT, Tohyama J, Zhang Y, Rothblat G, Rader DJ. Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation. 2007 Sep 11;116(11):1267-73. PubMed PMID: 1770963

195. Weibel GL, Alexander ET, Joshi MR, Rader DJ, Lund-Katz S, Phillips MC, Rothblat GH. Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux. Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):2022-9. PubMed PMID: 17615385

196. Skropeta D, Settasatian C, McMahon MR, Shearston K, Caiazza D, McGrath KC, Jin W, Rader DJ, Barter PJ, Rye KA. N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins. J Lipid Res. 2007 Sep;48(9):2047-57. PubMed PMID: 17545692

























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197. Ali K, Lund-Katz S, Lawson J, Phillips MC, Rader DJ. Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells. Atherosclerosis. 2008 Jan;196(1):201-9. PubMed PMID: 17531997; PubMed Central PMCID: PMC3328805

198. Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Puré E, FitzGerald GA. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation. 2008 Mar 11;117(10):1302-9. PMID: 18285567

199. Liu Y, Millar JS, Cromley DA, Graham M, Crooke R, Billheimer JT, Rader DJ. Knockdown of Acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. Biochim Biophys Acta. 2008 Mar;1781(3):97-104. PubMed PMID: 18252207.

200. Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase is increased in vivo by inflammation in humans. 2008 Feb 5;117(5):678-85.PubMed PMID: 18212282.

201. Marais AD, Raal FJ, Stein EA, Rader DJ, Blasetto J, Palmer M, Wilpshaar W. A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia. Atherosclerosis. 2008Mar;197(1):400-6. PubMed PMID: 17727860.

202. Millar JS, Brousseau ME, Diffenderfer MR, Barrett PH, Welty FK, Cohn JS, Wilson A, Wolfe ML, Nartsupha C, Schaefer PM, Digenio AG, Mancuso JP, Dolnikowski GG, Schaefer EJ, Rader DJ. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism. J Lipid Res. 2008 Mar;49(3):543-9. PubMed PMID: 18033754

203. Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, Jones GT, Rinkel GJ, Blankensteijn JD, Ronkainen A, Jääskeläinen JE, Kyo Y, Lenk GM, Sakalihasan N, Kostulas K, Gottsäter A, Flex A, Stefansson H, Hansen T, Andersen G, Weinsheimer S, Borch-Johnsen K, Jorgensen T, Shah SH, Quyyumi AA, Granger CB, Reilly MP, Austin H, Levey AI, Vaccarino V, Palsdottir E, Walters GB, Jonsdottir T, Snorradottir S, Magnusdottir D, Gudmundsson G, Ferrell RE, Sveinbjornsdottir S, Hernesniemi J, Niemelä M, Limet R, Andersen K, Sigurdsson G, Benediktsson R, Verhoeven EL, Teijink JA, Grobbee DE, Rader DJ, Collier DA, Pedersen O, Pola R, Hillert J, Lindblad B, Valdimarsson EM, Magnadottir HB, Wijmenga C, Tromp G, Baas AF, Ruigrok YM, van Rij AM, Kuivaniemi H, Powell JT, Matthiasson SE, Gulcher JR, Thorgeirsson G, Kong A, Thorsteinsdottir U, Stefansson K. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet. 2008 Feb;40(2):217-24. PubMed PMID: 18176561

204. Bloedon LT, Balikai S, Chittams J, Cunnane SC, Berlin JA, Rader DJ, Szapary PO. Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. J Am Coll Nutr. 2008 Feb;27(1):65-74. PubMed PMID: 18460483

205. Zhao L, Lee E, Zukas AM, Middleton MK, Kinder M, Acharya PS, Hall JA, Rader DJ, Puré E. CD44 Expressed on Both Bone Marrow-Derived and Non-Bone Marrow-Derived Cells Promotes Atherogenesis in ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1283-9. PubMed PMID: 18420998

206. Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol. 2008 Apr 29;51(17):1653-62. PubMed PMID: 18436117.

207. Samaha FF, McKenney J, Bloedon LT, Sasiela WJ, Rader DJ. Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hyper-cholesterolemia. Nat Clin Pract Cardiovasc Med. 2008 Aug;5(8):497-505. PMID: 18506154.

208. Bloedon LT, Dunbar R, Duffy D, Pinell-Salles P, Norris R, DeGroot BJ, Movva R, Navab M, Fogelman AM, Rader DJ. Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. J Lipid Res. 2008 Jun;49(6):1344-52. PubMed PMID: 18323573; PubMed Central PMCID: PMC2386905

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209. Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One. 2008;3(10):e3583. PubMed PMID: 18974833; PubMed Central PMCID: PMC2571995

210. Kolansky DM, Cuchel M, Clark BJ, Paridon S, McCrindle BW, Wiegers SE, Araujo L, Vohra Y, Defesche JC, Wilson JM, Rader DJ. Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia. Am J Cardiol. 2008 Dec 1;102(11):1438-43. PubMed PMID: 19026292

211. Brown RJ, Miller GC, Griffon N, Long CJ, Rader DJ. Glycosylation of endothelial lipase at asparagine-116 reduces activity and hydrolysis of native lipoproteins in vitro and in vivo. J Lipid Res. 2007 May;48(5):1132-9. PMID: 17322565

212. Millar JS, Duffy D, Gadi R, Bloedon LT, Dunbar RL, Wolfe ML, Movva R, Shah A, Fuki IV, McCoy M, Harris CJ, Wang MD, Howey DC, Rader DJ. Potent and Selective PPAR-{alpha} Agonist LY518674 Upregulates Both ApoA-I Production and Catabolism in Human Subjects with the Metabolic Syndrome. Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):140-6. PubMed PMID: 18988892; PubMed Central PMCID: PMC2746746

213. Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ. Overexpression of Apolipoprotein F Reduces HDL Cholesterol Levels In Vivo. Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):40-6. PubMed PMID: 19008531; PubMed Central PMCID: PMC2766561

214. Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, DerOhannessian S, Li M, Reilly MP, Aberle J, Evans D, Hegele RA, Rader DJ. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest. 2009 Apr;119(4):1042-50. PubMed PMID: 19287092; PubMed Central PMCID: PMC2662558

215. Briand F, Naik SU, Fuki I, Millar JS, Macphee C, Walker M, Billheimer J, Rothblat G, Rader DJ. Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol. Clin Transl Sci. 2009 Apr;2(2):127-33. PubMed PMID: 20169010; PubMed Central PMCID: PMC2823289

216. Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hu J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatly A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MCY, Chan J, So WY, Ma R, Shah SH, Granger SB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJA, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U,Stefansson K. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009 Mar;41(3):342-7. PubMed PMID: 19198610

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217. Tohyama J, Billheimer JT, Fuki IV, Rothblat GH, Rader DJ, Millar JS. Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice. Atherosclerosis. 2009 Jun;204(2):418-23. PubMed PMID: 18990393; PubMed Central PMCID: PMC2755296

218. Qasim AN, Metkus TS, Tadesse M, Lehrke M, Restine S, Wolfe ML, Hannenhalli S, Cappola T, Rader DJ, Reilly MP. Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in non-diabetic Caucasians. Clin Endocrinol (Oxf). 2009 May;70(5):698-705. PubMed PMID: 18710472; PubMed Central PMCID: PMC3108432.

219. An G, Miwa T, Song WL, Lawson JA, Rader DJ, Zhang Y, Song WC. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol. 2009 May;46(8-9):1702-9. PubMed PMID: 19297024; PubMed Central PMCID: PMC2705121

220. Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Kathiresan S, Meigs JB, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Voight BF, Kathiresan S, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Daly MJ, Purcell S, Voight BF, Purcell S, Nemesh J, Korn JM, McCarroll SA, Schwartz SM, Yee J, Kathiresan S, Lucas G, Subirana I, Elosua R, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Samani NJ, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS; Wellcome Trust Case Control Consortium, Schunkert H, Erdmann J, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Schunkert H, Samani NJ, Erdmann J, Ouwehand W, Hengstenberg C, Deloukas P, Scholz M, Cambien F, Reilly MP, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein SE, Scheffold T, Berger K, Stoll M, Huge A, Girelli D, Martinelli N, Olivieri O, Corrocher R, Morgan T, Spertus JA, McKeown P, Patterson CC, Schunkert H, Erdmann E, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O'Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Altshuler D. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Myocardial Infarction Genetics Consortium. Nat Genet. 2009 Mar;41(3):334-41. PMID: 19198609 PMCID: PMC2681011

221. Mohler ER 3rd, Shi Y, Moore J, Bantly A, Hamamdzic D, Yoder M, Rader DJ, Putt M, Zhang L, Parmacek M, Wilensky RL. Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterol. Cytometry A. 2009 Jan;75(1):75-82. PubMed PMID: 19051240

222. Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn DJ, Letrero R, Ciosek SL, Doody DR, Smith LM, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Reilly MP, Hakonarson H, Schwartz SM, Nathanson KL. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet. 2009 Jul;41(7):811-5. PubMed PMID: 19483682; PubMed Central PMCID: PMC2865677

223. Brown RJ, Edmondson AC, Griffon N, Hill TB, Fuki IV, Badellino KO, Li M, Wolfe ML, Reilly MP, Rader DJ. A naturally occurring variant of endothelial lipase associated with elevated

















HDL exhibits impaired synthesis. J Lipid Res. 2009 Sep;50(9):1910-6. PubMed PMID: 19411705; PubMed Central PMCID: PMC2724790

224. Jensen MK, Rimm EB, Mukamal KJ, Edmondson AC, Rader DJ, Vogel U, Tjønneland A, Sørensen TI, Schmidt EB, Overvad K. The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. Eur Heart J. 2009 Jul;30(13):1584-9. PubMed PMID: 19411665; PubMed Central PMCID: PMC2733737

225. Alexander ET, Tanaka M, Kono M, Saito H, Rader DJ, Phillips MC. Structural and functional consequences of the milano mutation (R173C) in human apolipoprotein A-I. J Lipid Res. 2009 Jul;50(7):1409-19. PubMed PMID: 19318685; PubMed Central PMCID: PMC2694339

226. Brousseau ME, Millar JS, Diffenderfer MR, Nartsupha C, Asztalos BF, Wolfe ML, Mancuso JP, Digenio AG, Rader DJ, Schaefer EJ. Effects of cholesteryl ester transfer protein inhibition on apolipoprotein (apo) A-II-containing HDL subspecies and ApoA-II metabolism. J Lipid Res. 2009 Jul;50(7):1456-62. PubMed PMID: 19193611; PubMed Central PMCID: PMC2694343.

227. Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med. 2009 Jun 16;150(12):830-9, W147-9. PubMed PMID: 19528562

228. Tanigawa H, Billheimer JT, Tohyama J, Fuki IV, Ng DS, Rothblat GH, Rader DJ. Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo. Circulation. 2009 Jul 14;120(2):160-9. PubMed PMID: 19564558; PubMed Central PMCID: PMC2796275

229. Griffon N, Jin W, Petty TJ, Millar J, Badellino KO, Saven JG, Marchadier DH, Kempner ES, Billheimer J, Glick JM, Rader DJ. Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation. J Biol Chem. 2009 Aug 28;284(35):23322-30. PubMed PMID: 19567873; PubMed Central PMCID: PMC2749106

230. Nishimoto T, Pellizzon MA, Aihara M, Stylianou IM, Billheimer JT, Rothblat G, Rader DJ. Fish oil promotes macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1502-8. PubMed PMID: 19574561; PubMed Central PMCID: PMC3315108.

231. Heffron SP, Parastatidis I, Cuchel M, Wolfe ML, Tadesse MG, Mohler ER 3rd, Ischiropoulos H, Rader DJ, Reilly MP. Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free Radic Biol Med. 2009 Oct 15;47(8):1140-6. PubMed PMID: 19631267; PubMed Central PMCID: PMC3651370

232. Stylianou IM, Svenson KL, VanOrman SK, Langle Y, Millar JS, Paigen B, Rader DJ. Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein. PLoS One. 2009 Aug 5;4(8):e6521. PubMed PMID: 19654867; PubMed Central PMCID: PMC2715880

233. Alexander ET, Weibel GL, Joshi MR, Vedhachalam C, de la Llera-Moya M, Rothblat GH, Phillips MC, Rader DJ. Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1496-501. PubMed PMID: 19661486; PubMed Central PMCID: PMC2943867.

234. Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Devaney J, Döring A, Elosua R, Epstein SE, Erber W, Falchi M, Garner SF, Ghori MJ, Goodall AH, Gwilliam R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CW, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Surakka I, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann HE, Van Heel DA, Tyler-Smith C,








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235. Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, Langenberg C, Prokopenko I, Saxena R, Sladek R, Aulchenko Y, Evans D, Waeber G, Erdmann J, Burnett MS, Sattar N, Devaney J, Willenborg C, Hingorani A, Witteman JC, Vollenweider P, Glaser B, Hengstenberg C, Ferrucci L, Melzer D, Stark K, Deanfield J, Winogradow J, Grassl M, Hall AS, Egan JM, Thompson JR, Ricketts SL, König IR, Reinhard W, Grundy S, Wichmann HE, Barter P, Mahley R, Kesaniemi YA, Rader DJ, Reilly MP, Epstein SE, Stewart AF, Van Duijn CM, Schunkert H, Burling K, Deloukas P, Pastinen T, Samani NJ, McPherson R, Davey Smith G, Frayling TM, Wareham NJ, Meigs JB, Mooser V, Spector TD. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. GIANT Consortium. PLoS Genet. 2009 Dec;5(12):e1000768. PubMed PMID: 20011104; PubMed Central PMCID: PMC2781107

236. Cuchel M, Lund-Katz S, de la Llera-Moya M, Millar JS, Chang D, Fuki I, Rothblat GH, Phillips MC, Rader DJ. Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):526-32. PubMed PMID: 20018934; PubMed Central PMCID: PMC2842952

237. de la Llera-Moya M, Drazul-Schrader D, Asztalos BF, Cuchel M, Rader DJ, Rothblat GH. The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):796-801. PubMed PMID: 20075420; PubMed Central PMCID: PMC2866499

238. Halbert SC, French B, Gordon RY, Farrar JT, Schmitz K, Morris PB, Thompson PD, Rader DJ, Becker DJ. Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. Am J Cardiol. 2010 Jan 15;105(2):198-204. PubMed PMID: 20102918

239. Yasuda T, Grillot D, Billheimer JT, Briand F, Delerive P, Huet S, Rader DJ. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):781-6. PubMed PMID: 20110577; PubMed Central PMCID: PMC3137455

240. Li M, Reilly MP, Rader DJ, Wang LS. Correcting population stratification in genetic association studies using a phylogenetic approach. Bioinformatics. 2010 Mar 15;26(6):798-806. PubMed PMID: 20097913; PubMed Central PMCID: PMC2832820

241. Yaffe K, Ackerson L, Tamura MK, Le Blanc P, Kusek JW, Sehgal AR, Cohen D, Anderson C, Appel L, Desalvo K, Ojo A, Seliger S, Robinson N, Makos G, Go AS; Chronic Renal Insufficiency Cohort Investigators. Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study. J Am Geriatr Soc. 2010 Feb;58(2):338-45. PubMed PMID: 20374407; PubMed Central PMCID: PMC2852884

242. Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH. Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster. Metabolism. 2010 Oct;59(10):1491-501. PubMed PMID: 20197195; PubMed Central PMCID: PMC2891578

243. Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Chen MH, Lapchyk N, Crenshaw A, Ziaugra L, Rachupka A, Benjamin EJ, Cupples LA, Fornage M, Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh CH, Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S, Rich SS, Rotter JI, Taylor HA






















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244. Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJ, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL, Farmer A, McGuffin P, Day R, Matthews K, Bakke P, Gulsvik A, Lucae S, Ising M, Brueckl T, Horstmann S, Wichmann HE, Rawal R, Dahmen N, Lamina C, Polasek O, Zgaga L, Huffman J, Campbell S, Kooner J, Chambers JC, Burnett MS, Devaney JM, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein S, Wilson JF, Wild SH, Campbell H, Vitart V, Reilly MP, Li M, Qu L, Wilensky R, Matthai W, Hakonarson HH, Rader DJ, Franke A, Wittig M, Schäfer A, Uda M, Terracciano A, Xiao X, Busonero F, Scheet P, Schlessinger D, St Clair D, Rujescu D, Abecasis GR, Grabe HJ, Teumer A, Völzke H, Petersmann A, John U, Rudan I, Hayward C, Wright AF, Kolcic I, Wright BJ, Thompson JR, Balmforth AJ, Hall AS, Samani NJ, Anderson CA, Ahmad T, Mathew CG, Parkes M, Satsangi J, Caulfield M, Munroe PB, Farrall M, Dominiczak A, Worthington J, Thomson W, Eyre S, Barton A; Wellcome Trust Case Control Consortium, Mooser V, Francks C, Marchini J. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet. 2010 May;42(5):436-40. PubMed PMID: 20418889; PubMed Central PMCID: PMC3612983.

245. Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C, Bradfield JP, Zhang H, Sleiman PM, Flory JH, Imielinski M, Frackelton EC, Chiavacci R, Thomas KA, Garris M, Otieno FG, Davidson M, Weiser M, Reichenberg A, Davis KL, Friedman JI, Cappola TP, Margulies KB, Rader DJ, Grant SF, Buxbaum JD, Gur RE, Hakonarson H. Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10584-9. PubMed PMID: 20489179; PubMed Central PMCID: PMC2890845

246. Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug;120(8):2889-99. PubMed PMID: 20592474; PubMed Central PMCID: PMC2912200.

247. Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res. 2010 Aug 6;107(3):357-64. PubMed PMID: 20558822; PubMed Central PMCID: PMC2948973

248. Musunuru K*, Strong A*, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S*, Rader DJ*. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010 Aug 5;466(7307):714-9. PMID: 20686566; PubMed Central PMCID: PMC3062476

249. Teslovich TM*, Musunuru K*, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan J, Lamina C, Ziegler A, Zhang W, Zee RY, Wright AF,












Witteman JC, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJ, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BW, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PK, Lucas G, Luben R, Loos RJ, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, König IR, Khaw KT, Kaprio J, Kaplan LM, Johansson A, Jarvelin MR, Cecile J W Janssens A, Ingelsson E, Igl W, Kees Hovingh G, Hottenga JJ, Hofman A, Hicks AA, Hengstenberg C, Heid IM, Hayward C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Gyllensten U, Guiducci C, Groop LC, Gonzalez E, Gieger C, Freimer NB, Ferrucci L, Erdmann J, Elliott P, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Geus EJ, de Faire U, Crawford G, Collins FS, Chen YD, Caulfield MJ, Campbell H, Burtt NP, Bonnycastle LL, Boomsma DI, Boekholdt SM, Bergman RN, Barroso I, Bandinelli S, Ballantyne CM, Assimes TL, Quertermous T, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr, Borecki IB, Gabriel SB, Wilson JG, Holm H, Thorsteinsdottir U, Gudnason V, Krauss RM, Mohlke KL, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Schadt EE, Rotter JI, Boerwinkle E, Strachan DP, Mooser V, Stefansson K, Reilly MP, Samani NJ, Schunkert H, Cupples LA*, Sandhu MS*, Ridker PM*, Rader DJ*, van Duijn CM*, Peltonen L*, Abecasis GR*, Boehnke M*, Kathiresan S*. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 5;466(7307):707-13. PubMed PMID: 20686565; PubMed Central PMCID: PMC3039276.

250. Gretarsdottir S, Baas AF, Thorleifsson G, Holm H, den Heijer M, de Vries JP, Kranendonk SE, Zeebregts CJ, van Sterkenburg SM, Geelkerken RH, van Rij AM, Williams MJ, Boll AP, Kostic JP, Jonasdottir A, Jonasdottir A, Walters GB, Masson G, Sulem P, Saemundsdottir J, Mouy M, Magnusson KP, Tromp G, Elmore JR, Sakalihasan N, Limet R, Defraigne JO, Ferrell RE, Ronkainen A, Ruigrok YM, Wijmenga C, Grobbee DE, Shah SH, Granger CB, Quyyumi AA, Vaccarino V, Patel RS, Zafari AM, Levey AI, Austin H, Girelli D, Pignatti PF, Olivieri O, Martinelli N, Malerba G, Trabetti E, Becker LC, Becker DM, Reilly MP, Rader DJ, Mueller T, Dieplinger B, Haltmayer M, Urbonavicius S, Lindblad B, Gottsäter A, Gaetani E, Pola R, Wells P, Rodger M, Forgie M, Langlois N, Corral J, Vicente V, Fontcuberta J, España F, Grarup N, Jørgensen T, Witte DR, Hansen T, Pedersen O, Aben KK, de Graaf J, Holewijn S, Folkersen L, Franco-Cereceda A, Eriksson P, Collier DA, Stefansson H, Steinthorsdottir V, Rafnar T, Valdimarsson EM, Magnadottir HB, Sveinbjornsdottir S, Olafsson I, Magnusson MK, Palmason R, Haraldsdottir V, Andersen K, Onundarson PT, Thorgeirsson G, Kiemeney LA, Powell JT, Carey DJ, Kuivaniemi H, Lindholt JS, Jones GT, Kong A, Blankensteijn JD, Matthiasson SE, Thorsteinsdottir U, Stefansson K. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692-7. PubMed PMID: 20622881

251. Li X, Millar JS, Brownell N, Briand F, Rader DJ. Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes. Biochem Pharmacol. 2010 Nov 1;80(9):1450-7. PubMed PMID: 20655299; PubMed Central PMCID: PMC3328801

252. Liu J, Afroza H, Rader DJ, Jin W. Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases. J Biol Chem. 2010 Sep 3;285(36):27561-70. PubMed PMID: 20581395; PubMed Central PMCID: PMC2934623

253. Tong F, Bilheimer JT, Shechtman CF, Liu Y, Crooke R, Graham M, Cohen DE, Sturley SL, Rader DJ. Decreased expression of ARV1 results in cholesterol retention in the endoplasmic










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reticulum and abnormal bile acid metabolism. J Biol Chem. 2010 Oct 29;285(44):33632-41. PubMed PMID: 20663892; PubMed Central PMCID: PMC2962461

254. Foster GD, Wyatt HR, Hill JO, Makris AP, Rosenbaum DL, Brill C, Stein RI, Mohammed BS, Miller B, Rader DJ, Zemel B, Wadden TA, Tenhave T, Newcomb CW, Klein S. Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med. 2010 Aug 3;153(3):147-57. PubMed PMID: 20679559; PubMed Central PMCID: PMC2949959

255. Khera AV, Wolfe ML, Cannon CP, Qin J, Rader DJ. On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study). Am J Cardiol. 2010 Aug 15;106(4):451-6. PubMed PMID: 20691300

256. Millar JS, Ky B, Wolfe ML, Pruscino L, Baer A, Rader DJ. Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels. ClinTransl Sci. 2010 Aug;3(4):140-6. PubMed PMID: 20718814; PubMed Central PMCID: PMC3125499

257. Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SL, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD. Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2648-54. PubMed PMID: 20847308; PubMed Central PMCID: PMC2988112

258. Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, Luan J, Ashford S, Wheeler E, Young EH, Hadley D, Thompson JR, Braund PS, Johnson T, Struchalin M, Surakka I, Luben R, Khaw KT, Rodwell SA, Loos RJ, Boekholdt SM, Inouye M, Deloukas P, Elliott P, Schlessinger D, Sanna S, Scuteri A, Jackson A, Mohlke KL, Tuomilehto J, Roberts R, Stewart A, Kesäniemi YA, Mahley RW, Grundy SM; Wellcome Trust Case Control Consortium, McArdle W, Cardon L, Waeber G, Vollenweider P, Chambers JC, Boehnke M, Abecasis GR, Salomaa V, Järvelin MR, Ruokonen A, Barroso I, Epstein SE, Hakonarson HH, Rader DJ, Reilly MP, Witteman JC, Hall AS, Samani NJ, Strachan DP, Barter P, van Duijn CM, Kooner JS, Peltonen L, Wareham NJ, McPherson R, Mooser V, Sandhu MS. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2264-76. PubMed PMID: 20864672; PubMed Central PMCID: PMC3891568.

259. Preuss M, König IR, Thompson JR, Erdmann J, Absher D, Assimes TL, Blankenberg S, Boerwinkle E, Chen L, Cupples LA, Hall AS, Halperin E, Hengstenberg C, Holm H, Laaksonen R, Li M, März W, McPherson R, Musunuru K, Nelson CP, Burnett MS, Epstein SE, O'Donnell CJ, Quertermous T, Rader DJ, Roberts R, Schillert A, Stefansson K, Stewart AF, Thorleifsson G, Voight BF, Wells GA, Ziegler A, Kathiresan S, Reilly MP, Samani NJ, Schunkert H; CARDIoGRAM Consortium. Design of the Coronary ARtery DIsease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet. 2010 Oct;3(5):475-83. PubMed PMID: 20923989; PubMed Central PMCID: PMC3070269

260. Kassim SH, Li H, Vandenberghe LH, Hinderer C, Bell P, Marchadier D, Wilson A, Cromley D, Redon V, Yu H, Wilson JM, Rader DJ. Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. PLoS One. 2010 Oct 19;5(10):e13424. PubMed PMID: 20976059; PubMed Central PMCID: PMC2957433

261. Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA,


















Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH Jr, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O'Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 2;56(19):1552-63.PubMed PMID: 20933357; PubMed Central PMCID: PMC3084526

262. Alexander ET, Vedhachalam C, Sankaranarayanan S, de la Llera-Moya M, Rothblat GH, Rader DJ, Phillips MC. Influence of apolipoprotein A-I domain structure on Macrophage Reverse Cholesterol Transport in Mice. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):320-7. PMID: 21071688; PubMed Central PMCID: PMC3024460

263. Burkhardt R*, Toh SA*, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL*, Rader DJ*. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest. 2010 Dec;120(12):4410-4. doi: 10.1172/JCI44213. PMID: 21084752; PubMed Central PMCID: PMC2993600.

264. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, Arking D, Balkau B, Barnes D, Boerwinkle E, Böhm B, Bonnefond A, Bonnycastle LL, Boomsma DI, Bornstein SR, Böttcher Y, Bumpstead S, Burnett-Miller MS, Campbell H, Cao A, Chambers J, Clark R, Collins FS, Coresh J, de Geus EJ, Dei M, Deloukas P, Döring A, Egan JM, Elosua R, Ferrucci L, Forouhi N, Fox CS, Franklin C, Franzosi MG, Gallina S, Goel A, Graessler J, Grallert H, Greinacher A, Hadley D, Hall A, Hamsten A, Hayward C, Heath S, Herder C, Homuth G, Hottenga JJ, Hunter-Merrill R, Illig T, Jackson AU, Jula A, Kleber M, Knouff CW, Kong A, Kooner J, Köttgen A, Kovacs P, Krohn K, Kühnel B, Kuusisto J, Laakso M, Lathrop M, Lecoeur C, Li M, Li M, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Mälarstig A, Mangino M, Martínez-Larrad MT, März W, McArdle WL, McPherson R, Meisinger C, Meitinger T, Melander O, Mohlke KL, Mooser VE, Morken MA, Narisu N, Nathan DM, Nauck M, O'Donnell C, Oexle K, Olla N, Pankow JS, Payne F, Peden JF, Pedersen NL, Peltonen L, Perola M, Polasek O, Porcu E, Rader DJ, Rathmann W, Ripatti S, Rocheleau G, Roden M, Rudan I, Salomaa V, Saxena R, Schlessinger D, Schunkert H, Schwarz P, Seedorf U, Selvin E, Serrano-Ríos M, Shrader P, Silveira A, Siscovick D, Song K, Spector TD, Stefansson K, Steinthorsdottir V, Strachan DP, Strawbridge R, Stumvoll M, Surakka I, Swift AJ, Tanaka T, Teumer A, Thorleifsson G, Thorsteinsdottir U, Tönjes A, Usala G, Vitart V, Völzke H, Wallaschofski H, Waterworth DM, Watkins H, Wichmann HE, Wild SH, Willemsen G, Williams GH, Wilson JF, Winkelmann J, Wright AF; WTCCC, Zabena C, Zhao JH, Epstein SE, Erdmann J, Hakonarson HH, Kathiresan S, Khaw KT, Roberts R, Samani NJ, Fleming MD, Sladek R, Abecasis G, Boehnke M, Froguel P, Groop L, McCarthy MI, Kao WH, Florez










JC, Uda M, Wareham NJ, Barroso I, Meigs JB. Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec;59(12):3229-39. PubMed PMID: 20858683; PubMed Central PMCID: PMC2992787

265. Watson CE, Weissbach N, Kjems L, Ayalasomayajula S, Zhang Y, Chang I, Navab M, Hama S, Hough G, Reddy ST, Soffer D, Rader DJ, Fogelman AM, Schecter A. Treatment of Patients with Cardiovascular Disease with L-4F, an Apo-A1 mimetic, Did Not Improve Select Biomarkers of HDL Function. J Lipid Res. 2011 Feb;52(2):361-73. PubMed PMID: 21068008; PubMed Central PMCID: PMC3023557

266. He J, Wang K, Edmondson AC, Rader DJ, Li C, Li M. Gene-based interaction analysis by incorporating external linkage disequilibrium information. Eur J Hum Genet. 2011 Feb;19(2):164-72. PubMed PMID: 20924406; PubMed Central PMCID: PMC3025792.

267. Khera AV*, Cuchel M*, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky R, Mohler ER, Rothblat GH, Rader DJ. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. 2011 Jan 13;364(2):127-35. PubMed PMID: 21226578; PubMed Central PMCID: PMC3030449

268. Reilly MP*, Li M*, He J, Ferguson JF, Stylianou IM, Mehta NM, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AFR, Assimes TL, Wild PS, Allayee H, Nitschke PL, Patel RS, †Myocardial Infarction Genetics Consortium, †Wellcome Trust Case Control Consortium, Martinelli N, Girelli D, Quyyumi AA, Anderson JL, Erdmann J, Hall AS, Schunkert H, Quertermous T, Blankenberg S, Hazen SL, Roberts R, Kathiresan S, Samani NJ, Epstein SE, Rader DJ. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 2011 Jan 29;377(9763):383-92. PubMed PMID: 21239051; PubMed Central PMCID: PMC3297116

269. Millar JS, Ikewaki K, Bloedon LT, Wolfe ML, Szapary PO, Rader DJ. Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL. J Lipid Res. 2011 Jan;52(1):136-42. PubMed PMID: 20971975; PubMed Central PMCID: PMC2999935

270. Nijstad N, Gautier T, Briand F, Rader DJ*, Tietge UJ*. Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice. Gastroenterology. 2011 Mar;140(3):1043-51. PubMed PMID: 21134376

271. Martin SS, Qasim AN, Wolfe M, St Clair C, Schwartz S, Iqbal N, Schutta M, Bagheri R, Mehta NN, Rader DJ, Reilly MP. Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance. Am J Cardiol. 2011 Feb 1;107(3):393-8. PubMed PMID: 21257004; PubMed Central PMCID: PMC3086062

272. Mehta NN, Krishnamoorthy P, Martin SS, St Clair C, Schwartz S, Iqbal N, Braunstein S, Schutta M, Rader DJ, Reilly MP. Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus. Am J Cardiol. 2011 Feb 1;107(3):406-11. PubMed PMID: 21257006; PubMed Central PMCID: PMC3040419

273. Toh SA, Millar JS, Billheimer J, Fuki I, Naik SU, Macphee C, Walker M, Rader DJ. PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI. 2011 Apr 1;81(7):934-41. PubMed PMID: 21291868; PubMed Central PMCID: PMC3315103

274. Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet M, Rader DJ, Tietge UJ. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochim Biophys Acta. 2011 Apr;1811(4):294-9. PubMed PMID: 21296681

275. Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Döring A, Thorand B, Li M, Reilly MP, Koenig W, Samani NJ, Rader DJ. Dense

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genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circ Cardiovasc Genet. 2011 Apr;4(2):145-55. PubMed PMID: 21303902; PubMed Central PMCID: PMC3319351

276. Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, Haiman CA, Hartiala J, Harris TB, Hazen SL, Heckbert SR, Henderson BE, Hirschhorn JN, Keating BJ, Kritchevsky SB, Larkin E, Li M, Rudock ME, McKenzie CA, Meigs JB, Meng YA, Mosley TH, Newman AB, Newton-Cheh CH, Paltoo DN, Papanicolaou GJ, Patterson N, Post WS, Psaty BM, Qasim AN, Qu L, Rader DJ, Redline S, Reilly MP, Reiner AP, Rich SS, Rotter JI, Liu Y, Shrader P, Siscovick DS, Tang WH, Taylor HA, Tracy RP, Vasan RS, Waters KM, Wilks R, Wilson JG, Fabsitz RR, Gabriel SB, Kathiresan S, Boerwinkle E. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet. 2011 Feb 10;7(2):e1001300. PubMed PMID: 21347282; PubMed Central PMCID: PMC3037413

277. Magge SN, Stettler N, Koren D, Levitt Katz LE, Gallagher PR, Mohler ER 3rd, Rader DJ. Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents. J Clin Endocrinol Metab. 2011 May;96(5):1549-54. PubMed PMID: 21367935; PubMed Central PMCID: PMC3085202.

278. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I; Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J; CARDIoGRAM Consortium, Samani NJ. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Mar 6;43(4):333-8. PubMed PMID: 21378990; PubMed Central PMCID: PMC3119261.

279. Nakaya K, Tohyama J, Naik SU, Tanigawa H, MacPhee C, Billheimer JT, Rader DJ. Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway. Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1276-82. PubMed PMID: 21441141; PubMed Central PMCID: PMC3202300

280. Potteaux S, Gautier EL, Hutchison SB, van Rooijen N, Rader DJ, Thomas MJ, Sorci-Thomas MG, Randolph GJ. Suppressed monocyte recruitment drives macrophage removal













from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest. 2011 May;121(5):2025-36. PubMed PMID: 21505265; PubMed Central PMCID: PMC3083793

281. Townsend RR, Anderson AH, Chen J, Gadebegku CA, Feldman HI, Fink JC, Go AS, Joffe M, Nessel LA, Ojo A, Rader DJ, Reilly MP, Teal V, Teff K, Wright JT, Xie D. Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Nephrol. 2011;33(6):477-84. PubMed PMID: 21525746; PubMed Central PMCID: PMC3095834

282. Kanetsky PA, Mitra N, Vardhanabhuti S, Vaughn DJ, Li M, Ciosek SL, Letrero R, D'Andrea K, Vaddi M, Doody DR, Weaver J, Chen C, Starr JR, Håkonarson H, Rader DJ, Godwin AK, Reilly MP, Schwartz SM, Nathanson KL. A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Hum Mol Genet. 2011 Aug 1;20(15):3109-17. PubMed PMID: 21551455; PubMed Central PMCID: PMC3131044.

283. Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Deiseroth A, Schnabel RB, Lubos E, Keller T, Eleftheriadis MS, Bickel C, Rupprecht HJ, Wilde S, Rossmann H, Diemert P, Cupples LA, Perret C, Erdmann J, Stark K, Kleber ME, Epstein SE, Voight BF, Kuulasmaa K, Li M, Schäfer AS, Klopp N, Braund PS, Sager HB, Demissie S, Proust C, König IR, Wichmann HE, Reinhard W, Hoffmann MM, Virtamo J, Burnett MS, Siscovick D, Wiklund PG, Qu L, El Mokthari NE, Thompson JR, Peters A, Smith AV, Yon E, Baumert J, Hengstenberg C, März W, Amouyel P, Devaney J, Schwartz SM, Saarela O, Mehta NN, Rubin D, Silander K, Hall AS, Ferrieres J, Harris TB, Melander O, Kee F, Hakonarson H, Schrezenmeir J, Gudnason V, Elosua R, Arveiler D, Evans A, Rader DJ, Illig T, Schreiber S, Bis JC, Altshuler D, Kavousi M, Witteman JC, Uitterlinden AG, Hofman A, Folsom AR, Barbalic M, Boerwinkle E, Kathiresan S, Reilly MP, O'Donnell CJ, Samani NJ, Schunkert H, Cambien F, Lackner KJ, Tiret L, Salomaa V, Munzel T, Ziegler A, Blankenberg S. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet. 2011 Aug 1;4(4):403-12. PubMed PMID: 21606135; PubMed Central PMCID: PMC3157552

284. Kassim SH, Vandenberghe LH, Hovhannisyan R, Wilson JM, Rader DJ. Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques. Physiol Genomics. 2011 Aug 16;43(15):911-6. PubMed PMID: 21628398; PubMed Central PMCID: PMC3180732

285. Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. PLoS One. 2011;6(7):e21209. PubMed PMID: 21750705; PubMed Central PMCID: PMC3130023.

286. Wang K, Edmondson AC, Li M, Gao F, Qasim AN, Devaney JM, Burnett MS, Waterworth DM, Mooser V, Grant S FA, Epstein SE, Reilly MP, Hakonarson H, Rader DJ. Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation. Front Genet. 2011 Jul 5;2:41. PubMed PMID: 22303337; PubMed Central PMCID: PMC3268595

287. Budoff MJ, Rader DJ, Reilly MP, Mohler ER 3rd, Lash J, Yang W, Rosen L, Glenn M, Teal V, Feldman HI; CRIC Study Investigators. Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis. 2011 Oct;58(4):519-26. PubMed PMID: 21783289; PubMed Central PMCID: PMC3183168

288. Yamamoto S, Tanigawa H, Li X, Komaru Y, Billheimer JT, Rader DJ. Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport. Circulation. 2011 Sep 20;124(12):1382-90. PubMed PMID: 21859969; PubMed Central PMCID: PMC3323112

289. Ricardo AC, Lash JP, Fischer MJ, Lora CM, Budoff M, Keane MG, Kusek JW, Martinez M, Nessel L, Stamos T, Ojo A, Rahman M, Soliman EZ, Yang W, Feldman HI, Go AS; CRIC and HCRIC Investigators. Cardiovascular disease among hispanics and non-hispanics in













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the chronic renal insufficiency cohort (CRIC) study. Clin J Am Soc Nephrol. 2011 Sep;6(9):2121-31. PubMed PMID: 21896829; PubMed Central PMCID: PMC3359008

290. International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. PubMed PMID: 21909115; PubMed Central PMCID: PMC3340926

291. Ricketts SL, Rensing KL, Holly JM, Chen L, Young EH, Luben R, Ashford S, Song K, Yuan X, Dehghan A, Wright BJ, Waterworth DM, Mooser V; GEMS Investigators, Waeber G, Vollenweider P, Epstein SE, Burnett MS, Devaney JM, Hakonarson HH, Rader DJ, Reilly MP, Danesh J, Thompson SG, Dunning AM, van Duijn CM, Samani NJ, McPherson R, Wareham NJ, Khaw KT, Boekholdt SM, Sandhu MS. Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease. Int J Mol Epidemiol Genet. 2011 Aug 30;2(3):261-85. PubMed PMID: 21915365; PubMed Central PMCID: PMC3166154

292. Weibel GL, Hayes S, Wilson A, Phillips MC, Billheimer J, Rader DJ, Rothblat GH. Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2865-71. PubMed PMID: 21940945; PubMed Central PMCID: PMC3220789.

293. IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet. 2011 Sep;7(9):e1002260. PubMed PMID: 21966275; PubMed Central PMCID: PMC3178591

294. Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011 Oct 16;43(11):1131-8. PubMed PMID: 22001757; PubMed Central PMCID: PMC3482372

295. Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH. Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids. Lipids Health Dis. 2011 Oct 21;10:186. PubMed PMID: 22018327; PubMed Central PMCID: PMC3217862

















296. Patel PJ, Khera AV, Jafri K, Wilensky RL, Rader DJ. The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery disease. J Am Coll Cardiol. 2011 Nov 8;58(20):2068-75. PubMed PMID: 22051328

297. Khetarpal SA, Edmondson AC, Raghavan A, Neeli H, Jin W, Badellino KO, Demissie S, Manning AK, Derohannessian SL, Wolfe ML, Cupples LA, Li M, Kathiresan S, Rader DJ. Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. PLoS Genet. 2011 Dec;7(12):e1002393. PubMed PMID: 22174694; PubMed Central PMCID: PMC3234219

298. O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW. Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1397-401. PubMed PMID: 22225633.

299. Lee AY, Yates NA, Ichetovkin M, Deyanova E, Southwick K, Fisher TS, Wang W, Loderstedt J, Walker N, Zhou H, Zhao X, Sparrow CP, Hubbard BK, Rader DJ, Sitlani A, Millar JS, Hendrickson RC. Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry. Clin Chem. 2012 Mar;58(3):619-27. PubMed PMID: 22249652

300. Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL, Shah R, Mucksavage MI, Bradfield JP, Hakonarson H, Wang X, Master SR, Rader DJ, Li M, Reilly MP. Translational studies of lipoprotein-associated phospholipase A in inflammation and atherosclerosis. J Am Coll Cardiol. 2012 Feb 21;59(8):764-72. PubMed PMID: 22340269; PubMed Central PMCID: PMC3285416

301. Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV, Hofman A, Karssen LC, Struchalin M, Floyd J, Igl W, Biloglav Z, Broer L, Pfeufer A, Pichler I, Campbell S, Zaboli G, Kolcic I, Rivadeneira F, Huffman J, Hastie ND, Uitterlinden A, Franke L, Franklin CS, Vitart V; DIAGRAM Consortium, Nelson CP, Preuss M; CARDIoGRAM Consortium, Bis JC, O'Donnell CJ, Franceschini N; CHARGE Consortium, Witteman JC, Axenovich T, Oostra BA, Meitinger T, Hicks AA, Hayward C, Wright AF, Gyllensten U, Campbell H, Schmitz G; EUROSPAN consortium. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. PLoS Genet. 2012;8(2):e1002490. PubMed PMID: 22359512; PubMed Central PMCID: PMC3280968.

302. Clarke R, Bennett DA, Parish S, Verhoef P, Dötsch-Klerk M, Lathrop M, Xu P, Nordestgaard BG, Holm H, Hopewell JC, Saleheen D, Tanaka T, Anand SS, Chambers JC, Kleber ME, Ouwehand WH, Yamada Y, Elbers C, Peters B, Stewart AF, Reilly MM, Thorand B, Yusuf S, Engert JC, Assimes TL, Kooner J, Danesh J, Watkins H, Samani NJ, Collins R, Peto R; MTHFR Studies Collaborative Group. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med. 2012 Feb;9(2):e1001177. PubMed PMID: 22363213; PubMed Central PMCID: PMC3283559

303. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012;7(2):e31616. PMCID: PMC3282742

304. Rader DJ, Parmacek MS. Secreted miRNAs suppress atherogenesis. Nat Cell Biol. 2012 Feb 29;14(3):233-5. PMID: 22373869

305. Musunuru K, Romaine SPR, Lettre G, Wilson JG, Volcik KA, Tsai MY, Taylor HA, Jr. Schreiner PJ, Rotter JI, Rich SS, Redline S, Psaty BM, Papanicolaou GJ, Ordovas JM, Liu K, Krauss RM, Glazer NL, Gabriel SB, Fornage M, Cupples LA, Buxbaum SG, Eric Boerwinkle E, Ballantyne CM, Kathiresan S, Rader DJ. Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project. PLoS One. 2012; 7(5): e36473. PMCID: PMC3357427















306. Anderson AH, Yang W, Hsu CY, Joffe MM, Leonard MB, Xie D, Chen J, Greene T, Jaar BG, Kao P, Kusek JW, Landis JR, Lash JP, Townsend RR, Weir MR, Feldman HI; CRIC Study Investigators. Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2012 Aug;60(2):250-61. PubMed PMID: 22658574.

307. Lucas G, Lluís-Ganella C, Subirana I, Musameh MD, Gonzalez JR, Nelson CP, Sentí M; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium, Schwartz SM, Siscovick D, O'Donnell CJ, Melander O, Salomaa V, Purcell S, Altshuler D, Samani NJ, Kathiresan S, Elosua R. Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One. 2012;7(8):e41730. PMCID: PMC3410908.

308. Elbers CC, Guo Y, Tragante V, van Iperen EP, Lanktree MB, Castillo BA, Chen F, Yanek LR, Wojczynski MK, Li YR, Ferwerda B, Ballantyne CM, Buxbaum SG, Chen YD, Chen WM, Cupples LA, Cushman M, Duan Y, Duggan D, Evans MK, Fernandes JK, Fornage M, Garcia Kooperberg C, Kritchevsky SB, Lacroix A, Liu K, Liu Y, Musunuru K, Newman AB, Onland-Moret NC, Ordovas J, Peter I, Post W, Redline S, Reis SE, Saxena R, Schreiner PJ, Volcik KA, Wang X, Yusuf S, Zonderland AB, Anand SS, Becker DM, Psaty B, Rader DJ, Reiner AP, Rich SS, Rotter JI, Sale MM, Tsai MY, Borecki IB, Hegele RA, Kathiresan S, Nalls MA, Taylor HA Jr, Hakonarson H, Sivapalaratnam S, Asselbergs FW, Drenos F, Wilson JG, Keating BJ. Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic Populations. PLoS One. 2012;7(12):e50198. PMCID: PMC3517599

309. Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM; Look AHEAD Research Group; DIAGRAM consortium, Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW 2nd, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet. 2012 Mar 9;90(3):410-25. PMCID: PMC3309185

310. IL6R Genetics Consortium Emerging Risk Factors Collaboration, Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjærg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AA, Trip MD, Steri M, Witteman JC, Qi L, van der Schoot CE, de Faire U, Erdmann J, Stringham HM, Koenig W, Rader DJ, Melzer D, Reich D, Psaty BM, Kleber ME, Panagiotakos DB, Willeit J, Wennberg P, Woodward M, Adamovic S, Rimm EB, Meade TW, Gillum RF, Shaffer JA, Hofman A, Onat A, Sundström J, Wassertheil-Smoller S, Mellström D, Gallacher J, Cushman M, Tracy RP, Kauhanen J, Karlsson M, Salonen JT,


Wilhelmsen L, Amouyel P, Cantin B, Best LG, Ben-Shlomo Y, Manson JE, Davey-Smith G, de Bakker PI, O'Donnell CJ, Wilson JF, Wilson AG, Assimes TL, Jansson JO, Ohlsson C, Tivesten Å, Ljunggren Ö, Reilly MP, Hamsten A, Ingelsson E, Cambien F, Hung J, Thomas GN, Boehnke M, Schunkert H, Asselbergs FW, Kastelein JJ, Gudnason V, Salomaa V, Harris TB, Kooner JS, Allin KH, Nordestgaard BG, Hopewell JC, Goodall AH, Ridker PM, Hólm H, Watkins H, Ouwehand WH, Samani NJ, Kaptoge S, Di Angelantonio E, Harari O, Danesh J. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012 Mar 31;379(9822):1205-13. PubMed PMID: 22421339; PubMed Central PMCID: PMC3316940

311. Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, König IR, Kraus WE, Granger CB, Engert JC, Hengstenberg C, Wichmann HE, Schreiber S, Tang WH, Ellis SG, Rader DJ, Hazen SL, Reilly MP, Samani NJ, Schunkert H, Roberts R, McPherson R. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet. 2012 Apr 1;5(2):217-25. PMID: 22319020

312. Martin SS, Qasim AN, Rader DJ, Reilly MP. C-reactive protein modifies the association of plasma leptin with coronary calcium in asymptomatic overweight individuals. Obesity (Silver Spring). 2012 Apr;20(4):856-61. PMID: 21738237

313. Annema W, Dikkers A, Freark de Boer J, Gautier T, Rensen PC, Rader DJ, Tietge UJ. ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma. J Lipid Res. 2012 May;53(5):929-40. PMCID: PMC3329392.

314. Ai D, Baez JM, Jiang H, Conlon DM, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, Fitzgerald K, Murphy AJ, Woo CW, Strong A, Ginsberg HN, Tabas I, Rader DJ, Tall AR. Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J Clin Invest. 2012 May 1;122(5):1677-87. PMCID: PMC3336989

315. Diffenderfer MR, Brousseau ME, Millar JS, Barrett PH, Nartsupha C, Schaefer PM, Wolfe ML, Dolnikowski GG, Rader DJ, Schaefer EJ. Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism. J Lipid Res. 2012 Jun;53(6):1190-9. PMCID: PMC3351826

316. Lu X, Wang L, Chen S, He L, Yang X, Shi Y, Cheng J, Zhang L, Gu CC, Huang J, Wu T, Ma Y, Li J, Cao J, Chen J, Ge D, Fan Z, Li Y, Zhao L, Li H, Zhou X, Chen L, Liu D, Chen J, Duan X, Hao Y, Wang L, Lu F, Liu Z, Yao C, Shen C, Pu X, Yu L, Fang X, Xu L, Mu J, Wu X, Zheng R, Wu N, Zhao Q, Li Y, Liu X, Wang M, Yu D, Hu D, Ji X, Guo D, Sun D, Wang Q, Yang Y, Liu F, Mao Q, Liang X, Ji J, Chen P, Mo X, Li D, Chai G, Tang Y, Li X, Du Z, Liu X, Dou C, Yang Z, Meng Q, Wang D, Wang R, Yang J, Schunkert H, Samani NJ, Kathiresan S, Reilly MP, Erdmann J; Coronary Artery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Peng X, Wu X, Liu D, Yang Y, Chen R, Qiang B, Gu D. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet. 2012 Jul 1;44(8):890-4. PMID: 22751097

317. Kimball AB, Szapary P, Mrowietz U, Reich K, Langley RG, You Y, Hsu MC, Yeilding N, Rader DJ, Mehta NN. Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasis. J Am cad Dermatol. 2012 Jul;67(1):76-85.. PMID: 22018756

318. He J, Li H, Edmondson AC, Rader DJ, Li M. A Gaussian copula approach for the analysis of secondary phenotypes in case-control genetic association studies. Biostatistics. 2012 Jul;13(3):497-508. PubMed PMID: 21933777; PMCID: PMC3372941.

319. Fischer MJ, Xie D, Jordan N, Kop WJ, Krousel-Wood M, Kurella Tamura M, Kusek JW, Ford V, Rosen LK, Strauss L, Teal VL, Yaffe K, Powe NR, Lash JP; CRIC Study Group Investigators. Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and






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320. Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB; on behalf of the American Heart Association Advocacy Coordinating Committee. Genetics and Cardiovascular Disease: A Policy Statement From the American Heart Association. Circulation. 2012 Jul 3;126(1):142-157. PubMed PMID: 22645291

321. Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC; National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project; Lung GO, Gibson RL, Bamshad MJ. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012 Jul8;44(8):886-9. PubMed PMID: 22772370 PubMed Central PMCID: PMC3702264

322. Boileau C, Guo DC, Hanna N, Regalado ES, Detaint D, Gong L, Varret M, Prakash SK, Li AH, d'Indy H, Braverman AC, Grandchamp B, Kwartler CS, Gouya L, Santos-Cortez RL, Abifadel M, Leal SM, Muti C, Shendure J, Gross MS, Rieder MJ, Vahanian A, Nickerson DA, Michel JB; National Heart, Lung, and Blood Institute (NHLBI) Go Exome Sequencing Project, Jondeau G, Milewicz DM. TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nat Genet. 2012 Jul 8;44(8):916-21. PubMed PMID: 22772371

323. Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest. 2012 Aug 1;122(8):2807-16. PMCID: PMC3408750 PubMed Central PMCID: PMC3408750

324. Jin SY, Tohyama J, Bauer RC, Cao NN, Rader DJ, Zheng XL. Genetic ablation of adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. Arterioscler Thromb Vasc Biol. 2012 Aug;32 (8):1817-23. PMID: 22652598 PubMed Central PMCID: PMC3422623

325. Anderson AH, Yang W, Hsu CY, Joffe MM, Leonard MB, Xie D, Chen J, Greene T, Jaar BG, Kao P, Kusek JW, Landis JR, Lash JP, Townsend RR, Weir MR, Feldman HI; CRIC Study Investigators. Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2012 Aug;60(2):250-61. PubMed PMID: 22658574 PubMed Central PMCID: PMC3565578 PubMed Central PMCID: PMC3565578

326. Foster GD, Shantz KL, Vander Veur SS, Oliver TL, Lent MR, Virus A, Szapary PO, Rader DJ, Zemel BS, Gilden-Tsai A. A randomized trial of the effects of an almond-enriched, hypocaloric diet in the treatment of obesity. Am J Clin Nutr. 2012 Aug;96(2):249-254. PMCID: PMC3396441 PubMed Central PMCID: PMC3396441

327. Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, Li M, Thorleifsson G, Newton-Cheh C, Musunuru K, Pirruccello JP, Saleheen D, Chen L, Stewart A FR, Schillert A, Thorsteinsdottir U, Thorgeirsson G, Anand S, Engert JC, Morgan T, Spertus J, Stoll M, Berger K, Martinelli N, Girelli D, McKeown PP, Patterson CC, Epstein SE, Devaney J, Burnett M-S, Mooser V, Ripatti S, Surakka I, Nieminen MS, Sinisalo J, Lokki M-L, Perola M, Havulinna A, de Faire U, Gigante B, Ingelsson E, Zeller T, Wild P, de Bakker PIW, Klungel OH, Maitland-van der Zee A-H, Peters BJM, de Boer A, Grobbee DE, Kamphuisen PW, Deneer VHM, Elbers CC, Onland-Moret NC, Hofker MH, Wijmenga C, Verschuren WMM, Boe JMA, van der Schouw YT, Rasheed A, Frossard P, Demissie S, Willer C, Do R, Ordovas JM, Abecasis GR, Boehnke M, Mohlke KL, Daly MJ, Guiducci C, Burtt NP, Surti A, Gonzalez E, Purcell S, Gabriel S, Marrugat J, Peden J, Erdmann J, Diemert P, Willenborg C, König IR, Fischer M, Hengstenberg C, Ziegler A,


Buysschaert I, Lambrechts D, Van de Werf F, Fox KA, El Mokhtari NE, Rubin D, Schrezenmeir J, Schreiber S, Schäfer A, Danesh J, Blankenberg S, Roberts R, McPherson R, Watkins H, Hall AS, Overvad K, Rimm E, Boerwinkle E, Tybjaerg-Hansen A, Cupples LA, Reilly MP, Melander O, Mannucci PM, Ardissino D, Siscovick D, Elosua R, Stefansson K, O'Donnell CJ, Salomaa V, Rader DJ, Peltonen L, Schwartz SM, Altshuler D, Kathiresan S. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012 August 11; 380(9841): 572–580. PMCID: PMC3419820 PubMed Central PMCID: PMC3419820

328. Lauring B, Taggart AK, Tata JR, Dunbar R, Caro L, Cheng K, Chin J, Colletti SL, Cote J, Khalilieh S, Liu J, Luo WL, Maclean AA, Peterson LB, Polis AB, Sirah W, Wu TJ, Liu X, Jin L, Wu K, Boatman PD, Semple G, Behan DP, Connolly DT, Lai E, Wagner JA, Wright SD, Cuffie C, Mitchel YB, Rader DJ, Paolini JF, Waters MG, Plump A. Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci Transl Med. 2012 Aug 22;4(148):148ra115 PubMed PMID: 22914621

329. Mehta NN, Li R, Krishnamoorthy P, Yu Y, Farver W, Rodrigues A, Raper A, Wilcox M, Baer A, DerOhannesian S, Wolfe M, Reilly MP, Rader DJ, VanVoorhees A, Gelfand JM. Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis. Atherosclerosis. 2012 Sep;224(1):218-21. PubMed PMID: 22858285

330. Grunwald JE, Alexander J, Ying GS, Maguire M, Daniel E, Whittock-Martin R, Parker C, McWilliams K, Lo JC, Go A, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Jaar BG; CRIC Study Group. Retinopathy and chronic kidney disease in the Chronic Renal Insufficiency Cohort (CRIC) study. Arch Ophthalmol. 2012 Sep 1;130(9):1136-44. PubMed PMID: 22965589 PubMed Central PMCID: PMC3719171

331. Usman MH, Qamar A, Gadi R, Lilly S, Goel H, Hampson J, Mucksavage ML, Nathanson GA, Rader DJ, Dunbar RL. Extended-Release Niacin Acutely Suppresses Postprandial Triglyceridemia. Am J Med. 2012 Oct;125 (10):1026-1035. PubMed PMID: 22840917

332. Magge SN, Prasad D, Koren D, Gallagher PR, Mohler ER 3rd, Stettler N, Levitt Katz LE, Rader DJ. Prediabetic obese adolescents have a more atherogenic lipoprotein profile compared with normoglycemic obese peers. J Pediatr. 2012 Nov;161(5):881-6. PubMed PMID: 22622051; PubMed Central PMCID: PMC3430826

333. Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey, KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, Dejong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, Lacroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB,


Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet. 2012 Nov 2;91(5):823-38. PMCID: PMC3487124

334. Kothapalli D, Liu SL, Bae YH, Monslow J, Xu T, Hawthorne EA, Byfield FJ, Castagnino P, Rao S, Rader DJ, Puré E, Phillips MC, Lund-Katz S, Janmey PA, Assoian RK. Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening. Cell Rep. 2012 Nov 29;2(5):1259-71. PMID: 23103162; PMCID: PMC3535179

335. Miksztowicz V, McCoy MG, Schreier L, Cacciagiú L, Elbert A, Gonzalez AI, Billheimer J, Eacho P, Rader DJ, Berg G. Endothelial lipase activity predicts high-density lipoprotein catabolism in hemodialysis: novel phospholipase assay in postheparin human plasma. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):3033-40. PMID: 23104846

336. Bose S, Krishnamoorthy P, Varanasi A, Nair J, Schutta M, Braunstein S, Iqbal N, Schwartz S, St Clair C, Master SR, Rader DJ, Reilly MP, Mehta NN. Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines. Obesity (Silver Spring). 2013 Jan;21(1):E118-23. PMID: 23505191

337. CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, Folkersen L, Goel A, Grundberg E, Havulinna AS, Ho WK, Hopewell JC, Eriksson N, Kleber ME, Kristiansson K, Lundmark P, Lyytikäinen LP, Rafelt S, Shungin D, Strawbridge RJ, Thorleifsson G, Tikkanen E, Van Zuydam N, Voight BF, Waite LL, Zhang W, Ziegler A, Absher D, Altshuler D, Balmforth AJ, Barroso I, Braund PS, Burgdorf C, Claudi-Boehm S, Cox D, Dimitriou M, Do R; DIAGRAM Consortium; CARDIOGENICS Consortium, Doney AS, Mokhtari NE, Eriksson P, Fischer K, Fontanillas P, Franco-Cereceda A, Gigante B, Groop L, Gustafsson S, Hager J, Hallmans G, Han BG, Hunt SE, Kang HM, Illig T, Kessler T, Knowles JW, Kolovou G, Kuusisto J, Langenberg C, Langford C, Leander K, Lokki ML, Lundmark A, McCarthy MI, Meisinger C, Melander O, Mihailov E, Maouche S, Morris AD, Müller-Nurasyid M; MuTHER Consortium, Nikus K, Peden JF, Rayner NW, Rasheed A, Rosinger S, Rubin D, Rumpf MP, Schäfer A, Sivananthan M, Song C, Stewart AF, Tan ST, Thorgeirsson G, Schoot CE, Wagner PJ; Wellcome Trust Case Control Consortium, Wells GA, Wild PS, Yang TP, Amouyel P, Arveiler D, Basart H, Boehnke M, Boerwinkle E, Brambilla P, Cambien F, Cupples AL, de Faire U, Dehghan A, Diemert P, Epstein SE, Evans A, Ferrario MM, Ferrières J, Gauguier D, Go AS, Goodall AH, Gudnason V, Hazen SL, Holm H, Iribarren C, Jang Y, Kähönen M, Kee F, Kim HS, Klopp N, Koenig W, Kratzer W, Kuulasmaa K, Laakso M, Laaksonen R, Lee JY, Lind L, Ouwehand WH, Parish S, Park JE, Pedersen NL, Peters A, Quertermous T, Rader DJ, Salomaa V, Schadt E, Shah SH, Sinisalo J, Stark K, Stefansson K, Trégouët DA, Virtamo J, Wallentin L, Wareham N, Zimmermann ME, Nieminen MS, Hengstenberg C, Sandhu MS, Pastinen T, Syvänen AC, Hovingh GK, Dedoussis G, Franks PW, Lehtimäki T, Metspalu A, Zalloua PA, Siegbahn A, Schreiber S, Ripatti S, Blankenberg SS, Perola M, Clarke R, Boehm BO, O'Donnell C, Reilly MP, März W, Collins R, Kathiresan S, Hamsten A, Kooner JS, Thorsteinsdottir U, Danesh J, Palmer CN, Roberts R, Watkins H, Schunkert H, Samani NJ. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2012 Dec 2. PMID: 23202125 PubMed Central PMCID: PMC3679547

338. Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ. Adeno-associated Viruses as Liver-Directed Gene Delivery Vehicles: Focus on Lipoprotein Metabolism. Methods Mol Biol. 2013;1027:273-307 PubMed PMID: 23912992.

339. Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ; IBC 50K SNP array BMI Consortium. Gene-centric meta-analyses of 108 912 individuals confirm known body




mass index loci and reveal three novel signals. Hum Mol Genet. 2013 Jan 1;22(1):184-201. PMID: 23001569 PubMed Central PMCID: PMC3522401

340. Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ. Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia. Hum Gene Ther. 2013 Jan;24(1):19-26. PubMed PMID: 22985273 PubMed Central PMCID: PMC3555111

341. Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ; Phase 3 HoFH Lomitapide Study investigators. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet. 2013 Jan 5;381(9860):40-6. PubMed PMID: 23122768

342. Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ; NHLBI Exome Sequencing Project, Akey JM. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 2013 Jan 10;493(7431):216-20. PubMed PMID: 23201682 PubMed Central PMCID: PMC3676746

343. Mohler ER 3rd, Sibley AA, Stein R, Davila-Roman V, Wyatt H, Badellino K, Rader DJ, Klein S, Foster GD. Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets. Obesity (Silver Spring). 2013 Mar;21(3):504-9. PubMed Central PMCID: PMC3630284

344. Kothapalli D, Castagnino P, Rader DJ, Phillips MC, Lund-Katz S, Assoian RK. Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222. Atherosclerosis. 2013 Mar;227(1):65-71. PMID: 23294923 PubMed PMID: 23418287

345. Norton N, Li D, Rampersaud E, Morales A, Martin ER, Zuchner S, Guo S, Gonzalez M, Hedges DJ, Robertson PD, Krumm N, Nickerson DA, Hershberger RE; National Heart, Lung, and Blood Institute GO Exome Sequencing Project and the Exome Sequencing Project Family Studies Project Team. Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circ Cardiovasc Genet. 2013 Apr;6(2):144-53. PubMed PMID: 23418287

346. Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S. Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):687-93. PubMed Central PMCID: PMC3660844

347. Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O'Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, Ginsburg GS. Implementing genomic medicine in the clinic: the future is here. Genet Med. 2013 Apr;15(4):258-67. PubMed PMID: 23306799

348. Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Leach IM, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R; METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF,



Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W; LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet. 2013 Apr 15;22(8):1663-78 PubMed Central PMCID: PMC3657476

349. Lieb W, Jansen H, Loley C, Pencina MJ, Nelson CP, Newton-Cheh C, Kathiresan S, Reilly MP, Assimes TL, Boerwinkle E, Hall AS, Hengstenberg C, Laaksonen R, McPherson R, Thorsteinsdottir U, Ziegler A, Peters A, Thompson JR, König IR, Erdmann J, Samani NJ, Vasan RS, Schunkert H; CARDIoGRAM, Assimes TL, Deloukas P, Erdmann J, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Schunkert H, Stewart AF. Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension. 2013 May;61(5):995-1001. PubMed PMID: 23478099

350. Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V, Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K, Tanaka Y, Hirose H, McCarthy MI, Morris AP; DIAGRAM; MuTHER; AGEN, Basit A, Barnett AH, Katulanda P, Matthews D, Mohan V, Wander GS, Singh JR, Mehra NK, Ralhan S, Kamboh MI, Mulvihill JJ, Maegawa H, Tobe K, Maeda S, Cho YS, Tai ES, Kelly MA, Chambers JC, Kooner JS, Kadowaki T, Deloukas P, Rader DJ, Danesh J, Sanghera DK. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes. 2013 May;62(5):1746-55. PubMed PMID: 23300278; PubMed Central PMCID: PMC3636649

351. Zhou H, Castro-Perez J, Lassman ME, Thomas T, Li W, McLaughlin T, Dan X, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg HN, Reyes-Soffer G, Cleary M, Previs SF, Roddy TP. Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1294-302. PubMed PMID: 23681806

352. O'Connor TD, Kiezun A, Bamshad M, Rich SS, Smith JD, Turner E; NHLBIGO Exome Sequencing Project; ESP Population Genetics, Statistical Analysis Working Group, Leal SM, Akey JM. Fine-scale patterns of population stratification confound rare variant association tests. PLoS One. 2013 Jul 4;8(7):e65834. PubMed PMID: 23861739; PubMed Central PMCID: PMC3701690.

353. Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB Sr, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ. High-density lipoproteins: A consensus statement from the National Lipid Association. J Am Coll Cardiol. 2013 Aug 27;62(9):789-98.PubMed PMID: 24079290

354. Picataggi A, Lim GF, Kent AP, Millar JS, Rader DJ, Stylianou IM. A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice. Mamm Genome. 2013 Aug;24(7-8):257-65. PMID: 23722970

355. Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1788-94. PubMed PMID: 23723371

356. Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, Ojeda F, Müller-Nurasyid M, Munzel TF, Psaty BM, Rice K, Rotter JI, Schnabel RB, Tang WH, Thorand B,


Erdmann J; CARDIoGRAM Consortium, Jacobs DR Jr, Wilson JG, Koenig W, Tracy RP, Blankenberg S, März W, Gross MD, Benjamin EJ, Hazen SL, Allayee H. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet. 2013 Aug 15;22(16):3381-93. PMID: 23620142

357. Ferguson JF, Matthews GJ, Townsend RR, Raj DS, Kanetsky PA, Budoff M, Fischer MJ, Rosas SE, Kanthety R, Rahman M, Master SR, Qasim A, Li M, Mehta NN, Shen H, Mitchell BD, O'Connell JR, Shuldiner AR, Ho WK, Young R, Rasheed A, Danesh J, He J, Kusek JW, Ojo AO, Flack J, Go AS, Gadegbeku CA, Wright JT, Saleheen D, Feldman HI, Rader DJ, Foulkes AS, Reilly MP. Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort Study. J Am Coll Cardiol. 2013 Aug 27;62(9):789-98. PMID: 23727086

358. van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A, Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA, Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H, Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Witteman JC, den HeijerM, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ, Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep;98(3):668-76. PubMed PMID: 23824729

359. Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ; VTE Consortium; STROKE Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2); C4D Consortium; CARDIoGRAM Consortium, Wallaschofski H, Smith NL, Tregouet D, Ridker PM, Tang W, Strachan DP, Hamsten A, O'Donnell CJ. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17;128(12):1310-24. PMID: 23969696

360. Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ. Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism. Methods Mol Biol. 2013;1027:273-307. PubMed PMID: 23912992.

361. Ho JE, Chen WY, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ; CARDIoGRAM Consortium; CHARGE Inflammation Working Group, Dehghan A, Lu C, Levy D, Newton-Cheh C; CHARGE Heart Failure Working Group, Lin H, Felix JF, Schreiter ER, Vasan RS,





Januzzi JL, Lee RT, Wang TJ, Assimes TL, Deloukas P, Erdmann J, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Schunkert H, Stewart AF. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest. 2013 Oct 1;123(10):4208-18. PMID: 23999434

362. Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stančáková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Altshuler D, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Mohlke KL, Ingelsson E, Abecasis GR, Daly MJ, Neale BM, Kathiresan S. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013 Nov;45(11):1345-52. PMID: 24097064

363. Global Lipids Genetics Consortium, Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I,




Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancáková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E, Abecasis GR. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013 Nov;45(11):1274-83 PMID: 24097068

364. Patel PJ, Khera AV, Wilensky RL, Rader DJ. Anti-oxidative and cholesterol efflux capacities of high-density lipoprotein are reduced in ischaemic cardiomyopathy. Eur J Heart Fail. 2013 Nov;15(11):1215-9. PMID: 23709232

365. Khera AV, Patel PJ, Reilly MP, Rader DJ. The Addition of Niacin to Statin Therapy Improves High-density Lipoprotein Cholesterol Levels but not Metrics of Functionality. J Am Coll Cardiol. 2013 Nov 12;62(20):1909-10 PubMed PMID: 24314353

366. Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EP, Li M, Leusink M, Trompet S, Verschuren JJ, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, van 't Hooft F, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Mateo Leach I, Breitling LP, Brenner H, Thiery J, Dallmeier D, Franco-Cereceda A, Boer JM, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day IN, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der Zee AH, Khaw KT, Keating BJ, van der Harst P, Price JF, Mehta SR, Yusuf S, Witteman JC, Franco OH, Jukema JW, de Knijff P, Tybjaerg-Hansen A, Rader DJ, Farrall M, Samani NJ, Kivimaki M, Fox KA, Humphries SE, Anderson JL, Boekholdt SM, Palmer TM, Eriksson P, Paré G, Hingorani AD, Sabatine MS, Mallat Z, Casas JP, Talmud PJ. Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study. J Am Coll Cardiol. 2013 Nov 19;62(21):1966-76. PMID: 23916927




367. Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis M, Kassim S, Somathanan S, Bell P, Johnston J, Rader DJ, Wilson JM. Biodistribution of AAV8 vectors expressing human LDL receptor in a mouse model of homozygous familial hypercholesterolemia. Hum Gene Ther Clin Dev. 2013 Dec;24(4):154-60. PMID: 24070336

368. Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Auer PL, Goel A, Gigante B, Barnes TA, Melander O, Orho-Melander M, Duga S, Sivapalaratnam S, Nikpay M, Martinelli N, Girelli D, Jackson RD, Kooperberg C, Lange LA, Ardissino D, McPherson R, Farrall M, Watkins H, Reilly MP, Rader DJ, de Faire U, Schunkert H, Erdmann J, Samani NJ, Charnas L, Altshuler D, Gabriel S, Kastelein JJ, Defesche JC, Nederveen AJ, Kathiresan S, Hovingh GK; National Heart, Lung, and Blood Institute GO Exome Sequencing Project. Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2909-14. PMID: 24072694

369. Hurt-Camejo E, Gautier T, Rosengren B, Dikkers A, Behrendt M, Grass DS, Rader DJ, Tietge UJ. Expression of Type IIA Secretory Phospholipase A2 Inhibits Cholesteryl Ester Transfer Protein Activity in Transgenic Mice. Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2707-14. PMID: 24115030

370. Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U; CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H, Assimes TL, Deloukas P, Holm H, König IR, Roberts R, Stewart AF. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 2013 Dec 19;504(7480):432-6 PMID: 24213632

371. Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, Odonnell CJ, Fornage M, Thorsteinsdottir U, Psaty BM, Hengstenberg C, Seshadri S, Erdmann J, Bis JC, Peters A, Boncoraglio GB, März W, Meschia JF, Kathiresan S, Ikram MA, McPherson R, Stefansson K, Sudlow C, Reilly MP, Thompson JR, Sharma P, Hopewell JC, Chambers JC, Watkins H, Rothwell PM, Roberts R, Markus HS, Samani NJ, Farrall M, Schunkert H; the METASTROKE Consortium; the CARDIoGRAM consortium; the C4D consortium; the International Stroke Genetics Consortium; Collaborators/second tier of authors. Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants. Stroke. 2014 Jan;45(1):24-36. PMID: 24262325

372. Li RC, Krishnamoorthy P, Derohannessian S, Doveikis J, Wilcox M, Thomas P, Rader DJ, Reilly MP, Van Voorhees A, Gelfand JM, Mehta NN. Psoriasis is associated with decreased plasma adiponectin levels independently of cardiometabolic risk factors. Clin Exp Dermatol. 2014 Jan;39(1):19-24. PMID: 24341476

373. Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G, Barter P, Betteridge J, Bruckert E, Cuevas A, Farnier M, Ferrannini E, Fioretto P, Genest J, Ginsberg HN, Gotto AM Jr, Hu D, Kadowaki T, Kodama T, Krempf M, Matsuzawa Y, Núñez-Cortés JM, Monfil CC, Ogawa H, Plutzky J, Rader DJ, Sadikot S, Santos RD, Shlyakhto E, Sritara P, Sy R, Tall A, Tan CE, Tokgözo Lu L, Toth PP, Valensi P, Wanner C, Zambon A, Zhu J, Zimmet P. Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol. 2014 Jan 24;13(1):26. PMID: 24460800

374. Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, Isaacs A, Jakobsdottir J, Feitosa MF, Davies G, Huffman JE, Manichaikul A, Davis B, Lohman K, Joon AY, Smith AV, Grove ML, Zanoni P, Redon V, Demissie S, Lawson K, Peters U, Carlson C, Jackson RD, Ryckman KK, Mackey RH, Robinson JG, Siscovick DS, Schreiner PJ, Mychaleckyj JC, Pankow JS, Hofman A,










Uitterlinden AG, Harris TB, Taylor KD, Stafford JM, Reynolds LM, Marioni RE, Dehghan A, Franco OH, Patel AP, Lu Y, Hindy G, Gottesman O, Bottinger EP, Melander O, Orho-Melander M, Loos RJ, Duga S, Merlini PA, Farrall M, Goel A, Asselta R, Girelli D, Martinelli N, Shah SH, Kraus WE, Li M, Rader DJ, Reilly MP, McPherson R, Watkins H, Ardissino D; NHLBI GO Exome Sequencing Project, Zhang Q, Wang J, Tsai MY, Taylor HA, Correa A, Griswold ME, Lange LA, Starr JM, Rudan I, Eiriksdottir G, Launer LJ, Ordovas JM, Levy D, Chen YD, Reiner AP, Hayward C, Polasek O, Deary IJ, Borecki IB, Liu Y, Gudnason V, Wilson JG, van Duijn CM, Kooperberg C, Rich SS, Psaty BM, Rotter JI, O'Donnell CJ, Rice K, Boerwinkle E, Kathiresan S, Cupples LA. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014 Feb 6;94(2):223-32. PMID: 24507774

375. Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJ. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis. 2014 Mar;233(1):234-41. PMCID: PMC3936605

376. Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, Rader DJ, Berg G. Role of SN1 Lipases on Plasma Lipids in Metabolic Syndrome and Obesity. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):669-75. PMID: 24458708

377. O'Brien EC, Roe MT, Fraulo ES, Peterson ED, Ballantyne CM, Genest J, Gidding SS, Hammond E, Hemphill LC, Hudgins LC, Kindt I, Moriarty PM, Ross J, Underberg JA, Watson K, Pickhardt D, Rader DJ, Wilemon K, Knowles JW. Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. Am Heart J. 2014 Mar;167(3):342-349.e17. PMID: 24576518

378. Rader DJ, Kastelein JJ. Lomitapide and Mipomersen: Two First-in-Class Drugs for Reducing Low-Density Lipoprotein Cholesterol in Patients With Homozygous Familial Hypercholesterolemia. Circulation. 2014 Mar 4;129(9):1022-32. PMID: 24589695

379. Hancock-Cerutti W, Rader DJ. Catch 5/8: Opposing effects of ABCG5/8 function on myocardial infarction and gallstone disease. J Am Coll Cardiol. 2014 May 27;63(20):2129-30 PubMed PMID: 24657684

380. Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JM, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Melander O, Nelson CP, Nolte IM, Pankratz N, Price TS, Shaffer J, Shah S, Tomaszewski M, van der Most PJ, Van Iperen EP, Vonk JM, Witkowska K, Wong CO, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Brown M, Burt A, Cooper-Dehoff RM, Connell JM, Cruickshanks KJ, Curtis SP, Davey-Smith G, Delles C, Gansevoort RT, Guo X, Haiqing S, Hastie CE, Hofker MH, Hovingh GK, Kim DS, Kirkland SA, Klein BE, Klein R, Li YR, Maiwald S, Newton-Cheh C, O'Brien ET, Onland-Moret NC, Palmas W, Parsa A, Penninx BW, Pettinger M, Vasan RS, Ranchalis JE, M Ridker P, Rose LM, Sever P, Shimbo D, Steele L, Stolk RP, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Wyatt S, Young JH, Zwinderman AH, Bezzina CR, Boerwinkle E, Casas JP, Caulfield MJ, Chakravarti A, Chasman DI, Davidson KW, Doevendans PA, Dominiczak AF, Fitzgerald GA, Gums JG, Fornage M, Hakonarson H, Halder I, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, Kumari M, März W, Murray SS, O'Connell JR, Oldehinkel AJ, Pankow JS, Rader DJ, Redline S, Reilly MP, Schadt EE, Kottke-Marchant K, Snieder H, Snyder M, Stanton AV, Tobin MD, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Watkins H, Johnson AD, Reiner AP, Zhu X, de Bakker PI, Levy D, Asselbergs FW, Munroe PB, Keating BJ. Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci. Am J Hum Genet. 2014 Mar 6;94(3):349-60. PMID: 24560520 PMCID: PMC3951943


381. Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ, Bamshad MJ, Nickerson DA; NHLBI GO Exome Sequencing Project. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Hum Mol Genet. 2014 Apr 15;23(8):1957-63. PMID: 24282029

382. Lassman ME, McAvoy T, Lee A, Chappell D, Wong O, Zhou H, Reyes-Soffer G, Ginsberg HN, Millar JS, Rader DJ, Gutstein DE, Laterza O. Practical Immunoaffinity-Enrichment LC-MS for Measuring Protein Kinetics of Low-Abundance Proteins. Clin Chem. 2014 Apr 21. PMID: 24751376

383. Singh N, Jacobs F, Rader DJ, Vanhaecke J, Van Cleemput J, De Geest B. Impaired cholesterol efflux capacity and vasculoprotective function of high-density lipoprotein in heart transplant recipients. J Heart Lung Transplant. 2014 May;33(5):499-506. PMID: 24630408

384. Javaheri A, Rader DJ, Javaheri S. Statin therapy in heart failure: is it time for a second look? Hypertension. 2014 May;63(5):909-10. PMID: 24516102

385. Mehta N, Qamar A, Qu L, Qasim AN, Mehta NN, Reilly MP, Rader DJ. Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits. Arterioscler Thromb Vasc Biol. 2014 May;34(5):1057-1063. PMID: 24626437; PubMed Central PMCID: PMC4104779

386. Javaheri A, Rader DJ. Apolipoprotein a-I and cholesterol efflux: the good, the bad, and the modified. Circ Res. 2014 May 23;114(11):1681-3. PubMed PMID:24855198; PubMed Central PMCID: PMC4104775

387. Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. Lipids. 2014 Jun;49(6):505-15. PubMed PMID: 24777581

388. Rosenson RS, Brewer HB, Rader DJ. Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome. Circ Res. 2014 Jun 6;114(12):1880-9. PubMed PMID: 24902972

389. Anthanont P, Polisecki E, Asztalos BF, Diffenderfer MR, Barrett PH, Millar JS, Billheimer J, Cuchel M, Rader DJ, Schaefer EJ. A novel ApoA-I truncation (ApoA-I(Mytilene)) associated with decreased ApoA-I production. Atherosclerosis. 2014 Jun 2;235(2):470-476 PubMed PMID: 24950002

390. Chirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R, Foster GD, Maislin G, Saif H, Broderick P, Chittams J, Hanlon AL, Pack AI. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014 Jun 12;370(24):2265-75. PubMed PMID: 24918371

391. Rahman M, Yang W, Akkina S, Alper A, Anderson AH, Appel LJ, He J, Raj DS, Schelling J, Strauss L, Teal V, Rader DJ; CRIC Study Investigators. Relation of Serum Lipids and Lipoproteins with Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol. 2014 Jul 7;9(7):1190-8. PubMed PMID: 24832097; PubMed Central PMCID: PMC4078958

392. Somanathan S, Jacobs F, Wang Q, Hanlon AL, Wilson JM, Rader DJ. AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia. Circ Res. 2014 Jul 14. PubMed PMID: 250237313

393. Tuteja S, Rader DJ. High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm. Clin Pharmacol Ther. 2014 Jul;96(1):48-56. PubMed PMID: 24713591

394. Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP; the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney





disease: findings from the Chronic Renal Insufficiency Cohort study. Eur Heart J. 2014 Aug 14;35(31):2115-22. PMID: 24306482 PMCID: PMC4132636

395. Rader DJ. Spotlight on HDL biology: new insights in metabolism, function, and translation. Cardiovasc Res. 2014 Aug 1;103(3):337-40. PubMed PMID: 25028388

396. Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA; NHLBI Exome Sequencing Project, Bamshad MJ. Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results. Am J Hum Genet. 2014 Aug 7;95(2):183-93. PMID: 25087612

397. Anthanont P, Polisecki E, Asztalos BF, Diffenderfer MR, Barrett PH, Millar JS, Billheimer J, Cuchel M, Rader DJ, Schaefer EJ. A novel ApoA-I truncation (ApoA-IMytilene) associated with decreased ApoA-I production. Atherosclerosis. 2014 Aug;235(2):470-6. PubMed PMID: 24950002

398. Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. Eur Heart J. 2014 Aug 14;35(31):2115-22. PMID: 24306482

399. Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Rader DJ, Musunuru K. Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing. Circ Res. 2014 Aug 15;115(5):488-92 PMID: 24916110 PMCID: PMC4134749

400. Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing. Circ Res. 2014 Aug 15;115(5):488-92. PMID: 24916110

401. Somanathan S, Jacobs F, Wang Q, Hanlon AL, Wilson JM, Rader DJ. AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia. Circ Res. 2014 Aug 29;115(6):591-9. PMID: 25023731

402. Lassman ME, McAvoy T, Lee AY, Chappell D, Wong O, Zhou H, Reyes-Soffer G, Ginsberg HN, Millar JS, Rader DJ, Gutstein DE, Laterza O. Practical immunoaffinity-enrichment LC-MS for measuring protein kinetics of low-abundance proteins. Clin Chem. 2014 Sep;60(9):1217-24. PMID: 24751376

403. Yang P, Belikova NA, Billheimer J, Rader DJ, Hill JS, Subbaiah PV. Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins. Lipids. 2014 Oct;49(10):987-96. PMID: 25167836

404. Tuteja S, Rader DJ. Dyslipidaemia: Cardiovascular prevention-end of the road for niacin? Nat Rev Endocrinol. 2014 Nov;10(11):646-7. PMID: 25178730

405. Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Mateo Leach I, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney AS, Dörr M,


Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LC, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson Å, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PK, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, vander Velde N, van Heemst D, van Oort FV, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma DI, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples LA, Danesh J, de Faire U, den Ruijter HM, Erbel R, Erdmann J, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Gansevoort RT, Gejman PV, Gieger C, Golay A, Gottesman O, Gudnason V, Gyllensten U, Haas DW, Hall AS, Harris TB, Hattersley AT, Heath AC, Hengstenberg C, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Jacobs KB, Jarvelin MR, Jousilahti P, Jula AM, Kaprio J, Kastelein JJ, Kayser M, Kee F, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kooner JS, Kooperberg C, Koskinen S, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lupoli S, Madden PA, Männistö S, Manunta P, Marette A, Matise TC, McKnight B, Meitinger T, Moll FL, Montgomery GW, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Ouwehand WH, Pasterkamp G, Peters A, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ritchie M, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Sebert S, Sever P, Shuldiner AR, Sinisalo J, Steinthorsdottir V, Stolk RP, Tardif JC, Tönjes A, Tremblay A, Tremoli E, Virtamo J, Vohl MC; Electronic Medical Records and Genomics (eMEMERGEGE) Consortium; MIGen Consortium; PAGEGE Consortium; LifeLines Cohort Study, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hayes MG, Hui J, Hunter DJ, Hveem K, Jukema JW, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Powell JE, Power C, Quertermous T, Rauramaa R, Reinmaa E, Ridker PM, Rivadeneira F, Rotter JI, Saaristo TE, Saleheen D, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Strauch K, Stumvoll M, Tuomilehto J, Uusitupa M, van der Harst P, Völzke H, Walker M, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Zanen P, Deloukas P, Heid IM, Lindgren CM, Mohlke KL, Speliotes EK, Thorsteinsdottir U, Barroso I, Fox CS, North KE, Strachan DP, Beckmann JS, Berndt SI, Boehnke M, Borecki IB, McCarthy MI, Metspalu A, Stefansson K, Uitterlinden AG, van Duijn CM, Franke L, Willer CJ, Price AL, Lettre G, Loos RJ, Weedon MN, Ingelsson E, O'Connell JR, Abecasis GR, Chasman DI, Goddard ME, Visscher PM, Hirschhorn JN, Frayling TM. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014 Nov;46(11):1173-86. PubMed PMID: 25282103; PubMed Central PMCID: PMC4250049


406. Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, Meitinger T, Kessler T, Kastrati A, Laugwitz KL, Siscovick D, Rotter JI, Hazen SL, Tracy R, Cresci S, Spertus J, Jackson R, Schwartz SM, Natarajan P, Crosby J, Muzny D, Ballantyne C, Rich SS, O'Donnell CJ, Abecasis G, Sunyaev S, Nickerson DA, Buring JE, Ridker PM, Chasman DI, Austin E, Ye Z, Kullo IJ, Weeke PE, Shaffer CM, Bastarache LA, Denny JC, Roden DM, Palmer C, Deloukas P, Lin DY, Tang ZZ, Erdmann J, Schunkert H, Danesh J, Marrugat J, Elosua R, Ardissino D, McPherson R, Watkins H, Reiner AP, Wilson JG, Altshuler D, Gibbs RA, Lander ES, Boerwinkle E, Gabriel S, Kathiresan S. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27;371(22):2072-82. PMID: 25390462

407. Knowles JW, O'Brien EC, Greendale K, Wilemon K, Genest J, Sperling LS, Neal WA, Rader DJ, Khoury MJ. Reducing the burden of disease and death from familial hypercholesterolemia: A call to action. Am Heart J. 2014 Dec;168(6):807-11. PMID: 25458642

408. Daugherty A, Tabas I, Rader DJ. Accelerating the pace of atherosclerosis research. Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):11-2. PubMed PMID: 25520521

409. Khera AV, Qamar A, Reilly MP, Dunbar RL, Rader DJ. Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia. Am J Cardiol. 2015 Jan 15;115(2):178-82. PubMed PMID: 25432415

410. Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H, Rader DJ. Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis. Circ Res. 2015 Feb 27;116(5):789-96. PubMed PMID: 25593281

411. Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H. Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction. PLoS Genet. 2015 Feb 3;11(2):e1004855. PubMed PMID: 25647241

412. Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL; NHLBI Exome Sequencing Project, Girelli D, Martinelli N, Farlow DN, DePristo MA, Roberts R, Stewart AF, Saleheen D, Danesh J, Epstein SE, Sivapalaratnam S, Kees Hovingh G, Kastelein JJ, Samani NJ, Schunkert H, Erdmann J, Shah SH, Kraus WE, Davies R, Nikpay M, Johansen CT, Wang J, Hegele RA, Hechter E, Marz W, Kleber ME, Huang J, Johnson AD, Li M, Burke GL, Gross M, Liu Y, Assimes TL, Heiss G, Lange EM, Folsom AR, Taylor HA, Olivieri O, Hamsten A, Clarke R, Reilly DF, Yin W, Rivas MA, Donnelly P, Rossouw JE, Psaty BM, Herrington DM, Wilson JG, Rich SS, Bamshad MJ, Tracy RP, Adrienne Cupples L, Rader DJ, Reilly MP, Spertus JA, Cresci S, Hartiala J, Wilson Tang WH, Hazen SL, Allayee H, Reiner AP, Carlson CS, Kooperberg C, Jackson RD, Boerwinkle E, Lander ES, Schwartz SM, Siscovick DS, McPherson R, Tybjaerg-Hansen A, Abecasis GR, Watkins H, Nickerson DA, Ardissino D, Sunyaev SR, O'Donnell CJ, Altshuler D, Gabriel S, Kathiresan S. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 Feb 5;518(7537):102-6. PMID: 25487149

413. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman, ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ,


Prokopenko I, Shungin D, Stančáková A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S, Bonnycastle LL, Böttcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen YD, Clarke R, Daw EW, de Craen AJ, Delgado G, Dimitriou M, Doney AS, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert H, Grammer TB, Gräßler J, Grönberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson Å, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PK, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Müller G, Müller-Nurasyid M, Musk AW, Nagaraja R, Nöthen MM, Nolte IM, Pilz S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q; LifeLines Cohort Study, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gådin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JR, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, Van't Hooft FM, Vinkhuyzen AA, Westra HJ, Zheng W, Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium, Heath AC, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hyppönen E, Illig T, Jacobs KB, Jarvelin MR, Jöckel KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJ, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PA, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PE, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tönjes A, Trégouët DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Völker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njølstad I, Oostra BA,


Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJ, Speliotes EK. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. PubMed PMID: 25673413; PubMed Central PMCID: PMC4382211

414. Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR, Esko T, Fall T, Kutalik Z, Luan J, Randall JC, Scherag A, Vedantam S, Wood AR, Chen J, Fehrmann R, Karjalainen J, Kahali B, Liu CT, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bragg-Gresham JL, Buyske S, Demirkan A, Ehret GB, Feitosa MF, Goel A, Jackson AU, Johnson T, Kleber ME, Kristiansson K, Mangino M, Mateo Leach I, Medina-Gomez C, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Stančáková A, Ju Sung Y, Tanaka T, Teumer A, Van Vliet-Ostaptchouk JV, Yengo L, Zhang W, Albrecht E, Ärnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Böhringer S, Bonnet F, Böttcher Y, Bruinenberg M, Carba DB, Caspersen IH, Clarke R, Daw EW, Deelen J, Deelman E, Delgado G, Doney AS, Eklund N, Erdos MR, Estrada K, Eury E, Friedrich N, Garcia ME, Giedraitis V, Gigante B, Go AS, Golay A, Grallert H, Grammer TB, Gräßler J, Grewal J, Groves CJ, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heikkilä K, Herzig KH, Helmer Q, Hillege HL, Holmen O, Hunt SC, Isaacs A, Ittermann T, James AL, Johansson I, Juliusdottir T, Kalafati IP, Kinnunen L, Koenig W, Kooner IK, Kratzer W, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Mach F, Magnusson PK, Mahajan A, McArdle WL, Menni C, Merger S, Mihailov E, Milani L, Mills R, Moayyeri A, Monda KL, Mooijaart SP, Mühleisen TW, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R, Nalls MA, Narisu N, Glorioso N, Nolte IM, Olden M, Rayner NW, Renstrom F, Ried JS, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Sennblad B, Seufferlein T, Sitlani CM, Vernon Smith A, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tayo BO, Thorand B, Thorleifsson G, Tomaschitz A, Troffa C, van Oort FV, Verweij N, Vonk JM, Waite LL, Wennauer R, Wilsgaard T, Wojczynski MK, Wong A, Zhang Q, Hua Zhao J, Brennan EP, Choi M, Eriksson P, Folkersen L, Franco-Cereceda A, Gharav AG, Hedman ÅK, Hivert MF, Huang J, Kanoni S, Karpe F, Keildson S, Kiryluk K, Liang L, Lifton RP, Ma B, McKnight AJ, McPherson R, Metspalu A, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Olsson C, Perry JR, Reinmaa E, Salem RM, Sandholm N, Schadt EE, Scott RA, Stolk L, Vallejo EE, Westra HJ, Zondervan KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium, Amouyel P, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Brown MJ, Burnier M, Campbell H, Chakravarti A, Chines PS, Claudi-Boehm S, Collins FS, Crawford DC, Danesh J, de Faire U, de Geus EJ, Dörr M, Erbel R, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gieger C, Gudnason V, Haiman CA, Harris TB, Hattersley AT, Heliövaara M, Hicks AA, Hingorani AD, Hoffmann W, Hofman A, Homuth G, Humphries SE, Hyppönen E, Illig T, Jarvelin MR, Johansen B, Jousilahti P, Jula AM, Kaprio J, Kee F, Keinanen-Kiukaanniemi SM, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Musk AW,


Möhlenkamp S, Morris AD, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Palmer LJ, Penninx BW, Peters A, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Shuldiner AR, Staessen JA, Steinthorsdottir V, Stolk RP, Strauch K, Tönjes A, Tremblay A, Tremoli E, Vohl MC, Völker U, Vollenweider P, Wilson JF, Witteman JC, Adair LS, Bochud M, Boehm BO, Bornstein SR, Bouchard C, Cauchi S, Caulfield MJ, Chambers JC, Chasman DI, Cooper RS, Dedoussis G, Ferrucci L, Froguel P, Grabe HJ, Hamsten A, Hui J, Hveem K, Jöckel KH, Kivimaki M, Kuh D, Laakso M, Liu Y, März W, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sinisalo J, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ, Watkins H, Wichmann HE, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki IB, Deloukas P, Franke L, Frayling TM, Groop LC, Hunter DJ, Kaplan RC, O'Connell JR, Qi L, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Willer CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK, North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJ, Cupples LA, Morris AP, Lindgren CM, Mohlke KL. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-96. PubMed PMID: 25673412

415. Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS; CARDIoGRAM, Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF. Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. J Am Heart Assoc. 2015 Mar 11;4(3):e001544. PMID: 25762803

416. Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS, Rader DJ, Reilly MP. Knockout of adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation. 2015 Mar 31;131(13):1202-13. PMID: 25712206; PubMed Central PMCID: PMC4382454

417. Hovingh GK, Rader DJ, Hegele RA. HDL re-examined. Curr Opin Lipidol. 2015 Apr;26(2):127-32. PubMed PMID: 25692348

418. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr;8(2):343-50. PubMed PMID: 25632026; PubMed Central PMCID: PMC4406825

419. Rader DJ. Human genetics of atherothrombotic disease and its risk factors. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):741-7. PubMed PMID: 25810293

420. Nelson CP, Hamby SE, Saleheen D, Hopewell JC, Zeng L, Assimes TL, Kanoni S, Willenborg C, Burgess S, Amouyel P, Anand S, Blankenberg S, Boehm BO, Clarke RJ, Collins R, Dedoussis G, Farrall M, Franks PW, Groop L, Hall AS, Hamsten A, Hengstenberg C, Hovingh GK, Ingelsson E, Kathiresan S, Kee F, König IR, Kooner J, Lehtimäki T, März W, McPherson R, Metspalu A, Nieminen MS, O'Donnell CJ, Palmer CN, Peters A, Perola M, Reilly MP, Ripatti S, Roberts R, Salomaa V, Shah SH, Schreiber S, Siegbahn A, Thorsteinsdottir U, Veronesi G, Wareham N, Willer CJ, Zalloua PA, Erdmann J, Deloukas P, Watkins H, Schunkert H, Danesh J, Thompson JR, Samani NJ; CARDIoGRAM+C4D Consortium. Genetically determined height and coronary artery disease. N Engl J Med. 2015 Apr 23;372(17):1608-18. PubMed PMID: 25853659

421. Luthi AJ, Lyssenko NN, Quach D, McMahon KM, Millar JS, Vickers KC, Rader DJ, Phillips MC, Mirkin CA, Thaxton CS. Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high-density lipoprotein. J Lipid Res. 2015 May;56(5):972-85.


PMID: 25652088 422. deGoma EM, Salavati A, Shinohara RT, Saboury B, Pollan L, Schoen M, Torigian DA, Mohler

ER, Dunbar RL, Litt HI, Woo J, Rader DJ, Alavi A, Mehta NN. A Pilot Trial to Examine the Effect of High-Dose Niacin on Arterial Wall Inflammation Using Fluorodeoxyglucose Positron Emission Tomography. Acad Radiol. 2015 May;22(5):600-9. PubMed PMID: 25708866

423. Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2015 Jun;125(6):2510-22. PubMed PMID: 25961461

424. Interleukin 1 Genetics Consortium. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2015 Apr;3(4):243-53. Erratum in: Lancet Diabetes Endocrinol. 2015 Jun;3(6):e4. PubMed PMID: 25726324

425. Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron HD, Marais AD, Hegele RA, Sirtori CR, Shah PK, Gaudet D, Vigna GB, Sachais BS, Di Giacomo S, du Plessis AM, Bloedon LT, Balser J, Rader DJ, Cuchel M; Phase 3 HoFH Lomitapide Study Investigators. The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - A post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis. 2015 Jun;240(2):408-414. PubMed PMID: 25897792

426. Agarwala AP, Rodrigues A, Risman M, McCoy M, Trindade K, Qu L, Cuchel M, Billheimer J, Rader DJ. High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1515-9. PubMed PMID: 25838421

427. Zhang H, Xue C, Shah R, Bermingham K, Hinkle CC, Li W, Rodrigues A, Tabita-Martinez J, Millar JS, Cuchel M, Pashos E, Liu Y, Yan R, Yang W, Gosai SJ, VanDorn D, Chou S, Gregory BD, Morrisey E, Li M, Rader DJ, Reilly MP. Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease. Circ Res. 2015 Jun 19;117(1):17-28. PMID: 25904599

428. Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, Koiranen M, Ligthart L, McMahon G, Pedersen LM, Willenborg C, Won HH, Olesen J, Artto V, Assimes TL, Blankenberg S, Boomsma DI, Cherkas L, Davey Smith G, Epstein SE, Erdmann J, Ferrari MD, Göbel H, Hall AS, Jarvelin MR, Kallela M, Kaprio J, Kathiresan S, Lehtimäki T, McPherson R, März W, Nyholt DR,O'Donnell CJ, Quaye L, Rader DJ, Raitakari O, Roberts R, Schunkert H, Schürks M, Stewart AF, Terwindt GM, Thorsteinsdottir U, van den Maagdenberg AM, van Duijn C, Wessman M, Kurth T, Kubisch C, Dichgans M, Chasman DI, Cotsapas C, Zwart JA, Samani NJ, Palotie A; CARDIoGRAM Consortium and the International Headache Genetics Consortium. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet. 2015 Jul 2;1(1):e10. PubMed PMID: 27066539; PubMed Central PMCID: PMC4821079

429. Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJ, Boekholdt SM, Khaw KT, Wareham N, Rader DJ. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol. 2015 Jul;3(7):507-13. PMID: 26025389

430. Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT Jr, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, Hsu L, Jackson RD, Jarvik GP, Kim DS, Lakshminarayan K, Lange LA, Manichaikul A, Quinlan AR, Singleton AB, Thornton TA, Nickerson DA, Peters U, Rich SS; National Heart, Lung, and Blood Institute Exome Sequencing Project. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.


JAMA Neurol. 2015 Jul;72(7):781-8. PubMed PMID: 25961151 431. Hovingh GK, Kastelein JJ, van Deventer SJ, Round P, Ford J, Saleheen D, Rader DJ, Brewer

HB, Barter PJ. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2015 Aug 1;386(9992):452-60. PubMed PMID: 26047975

432. Qamar A, Khetarpal SA, Khera AV, Qasim A, Rader DJ, Reilly MP. Plasma Apolipoprotein C-III Levels, Triglycerides, and Coronary Artery Calcification in Type 2 Diabetics. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1880-8. PubMed PMID: 26069232; PubMed Central PMCID: PMC4556282

433. Shah R, Matthews GJ, Shah RY, McLaughlin C, Chen J, Wolman M, Master SR, Chai B, Xie D, Rader DJ, Raj DS, Mehta NN, Budoff M, Fischer MJ, Go AS, Townsend RR, He J, Kusek JW, Feldman HI, Foulkes AS, Reilly MP; CRIC Study Investigators. Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2015 Aug;66(2):266-73. PubMed PMID: 25795074; PubMed Central PMCID: PMC4516570.

434. Asch DA, Rader DJ, Merchant RM. Mining the social mediome. Trends Mol Med. 2015 Jul 10. Trends Mol Med. 2015 Sep;21(9):528-9. PubMed PMID: 26341614

435. Khera AV, Qamar A, Murphy SA, Cannon CP, Sabatine MS, Rader DJ. On-Statin Resistin, Leptin, and Risk of Recurrent Coronary Events After Hospitalization for an Acute Coronary Syndrome (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Study). Am J Cardiol. 2015 Sep 1;116(5):694-8. PubMed PMID: 26119654

436. Rader DJ. Lysosomal Acid Lipase Deficiency - A New Therapy for a Genetic Lipid Disease. N Engl J Med. 2015 Sep 10;373(11):1071-1073. PubMed PMID: 26352819

437. CARDIoGRAMplusC4D Consortium. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015 Oct;47(10):1121-30. PubMed PMID: 26343387; PubMed Central PMCID: PMC4589895

438. Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Bottinger EP, Buring JE, Chambers JC, Collins R, Cupples LA, Danesh J, Demuth I, Elosua R, Epstein SE, Esko T, Feitosa MF, Franco OH, Franzosi MG, Granger CB, Gu D, Gudnason V, Hall AS, Hamsten A, Harris TB, Hazen SL, Hengstenberg C, Hofman A, Ingelsson E, Iribarren C, Jukema JW, Karhunen PJ, Kim BJ, Kooner JS, Kullo IJ, Lehtimäki T, Loos RJ, Melander O, Metspalu A, März W, Palmer CN, Perola M, Quertermous T, Rader DJ, Ridker PM, Ripatti S, Roberts R, Salomaa V, Sanghera DK, Schwartz SM, Seedorf U, Stewart AF, Stott DJ, Thiery J, Zalloua PA, O'Donnell CJ, Reilly MP, Assimes TL, Thompson JR, Erdmann J, Clarke R, Watkins H, Kathiresan S, McPherson R, Deloukas P, Schunkert H, Samani NJ, Farrall M; CARDIoGRAMplusC4D Consortium. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015 Oct;47(10):1121-30. PubMed PMID: 26343387; PubMed Central PMCID: PMC4589895

439. Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, Steger DJ, Rader DJ. Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPa. J


Clin Invest. 2015 Oct 1;125(10):3809-18. PubMed PMID: 26348894 440. Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang

J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest. 2015 Oct 1;125(10):3819-30. PubMed PMID: 26368306

441. Lagor WR, Tong F, Jarrett KE, Lin W, Conlon DM, Smith M, Wang MY, Yenilmez BO, McCoy MG, Fields DW, O'Neill SM, Gupta R, Kumaravel A, Redon V, Ahima RS, Sturley SL, Billheimer JT, Rader DJ. Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure. Nutr Diabetes. 2015 Oct 19;5:e181. PubMed PMID: 26479315; PubMed Central PMCID: PMC4631934

442. Iqbal J, Walsh MT, Hammad SM, Cuchel M, Tarugi P, Hegele RA, Davidson NO, Rader DJ, Klein RL, Hussain MM. Microsomal triglyceride transfer protein transfers and determines plasma concentrations of ceramide and sphingomyelin, but not glycosylceramide. J Biol Chem. J Biol Chem. 2015 Oct 23;290(43):25863-75. PubMed PMID: 26350457

443. Hegele RA, Gidding SS, Ginsberg HN, McPherson R, Raal FJ, Rader DJ, Robinson JG, Welty FK. Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council. Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2269-8 PubMed PMID: 26376908

444. Natarajan P, Kohli P, Baber U, Nguyen KD, Sartori S, Reilly DF, Mehran R, Muntendam P, Fuster V, Rader DJ, Kathiresan S. Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. J Am Coll Cardiol. 2015 Nov 3;66(18):2053-5. PubMed PMID: 26516010

445. Khera AV, Millar JS, Ruotolo G, Wang MD, Rader DJ. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2. PMID: 26112886

446. Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17;66(20):2201-10. PubMed PMID: 26564598

447. Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT. A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14623-8. PubMed PMID: 265540036

448. Wolf JH, Holmes MV, Fouraschen S, Keating BJ, Baker T, Emond J, Rader DJ, Shaked A, Olthoff KM. Serum lipid expression correlates with function and regeneration following living donor liver transplantation. Liver Transpl. 2016 Jan;22(1):103-10. PubMed PMID: 26202132; PubMed Central PMCID: PMC4718769

449. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK, Zonderman AB, Nolte IM, van der Most PJ, Wright AF, Shuldiner AR, Morrison AC, Hofman A, Smith AV, Dreisbach AW, Franke A, Uitterlinden AG, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson Å, Demirkan A, Kollerits B, Freedman BI, Ponte B, Oostra BA, Paulweber B, Krämer BK, Mitchell BD, Buckley BM, Peralta CA, Hayward C, Helmer C, Rotimi CN, Shaffer CM, Müller C, Sala C, van Duijn CM, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick DS, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson EJ, Holliday EG, Boerwinkle E, Salvi E, Bottinger EP, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu FB, Navis GJ, Curhan GC, Ehret GB, Homuth G, Coassin S, Thun GA, Pistis G, Gambaro G, Malerba G, Montgomery GW, Eiriksdottir G, Jacobs G, Li G, Wichmann HE, Campbell H, Schmidt H, Wallaschofski H, Völzke H, Brenner H, Kroemer HK, Kramer H, Lin H, Mateo Leach I, Ford I, Guessous I, Rudan I, Prokopenko I, Borecki I, Heid IM, Kolcic I, Persico I, Jukema JW, Wilson JF, Felix JF, Divers J, Lambert JC, Stafford JM, Gaspoz JM, Smith JA, Faul JD, Wang JJ, Ding J,


Hirschhorn JN, Attia J, Whitfield JB, Chalmers J, Viikari J, Coresh J, Denny JC, Karjalainen J, Fernandes JK, Endlich K, Butterbach K, Keene KL, Lohman K, Portas L, Launer LJ, Lyytikäinen LP, Yengo L, Franke L, Ferrucci L, Rose LM, Kedenko L, Rao M, Struchalin M, Kleber ME, Cavalieri M, Haun M, Cornelis MC, Ciullo M, Pirastu M, de Andrade M, McEvoy MA, Woodward M, Adam M, Cocca M, Nauck M, Imboden M, Waldenberger M, Pruijm M, Metzger M, Stumvoll M, Evans MK, Sale MM, Kähönen M, Boban M, Bochud M, Rheinberger M, Verweij N, Bouatia-Naji N, Martin NG, Hastie N, Probst-Hensch N, Soranzo N, Devuyst O, Raitakari O, Gottesman O, Franco OH, Polasek O, Gasparini P, Munroe PB, Ridker PM, Mitchell P, Muntner P, Meisinger C, Smit JH; ICBP Consortium; AGEN Consortium; CARDIOGRAM; CHARGe-Heart Failure Group; ECHOGen Consortium, Kovacs P, Wild PS, Froguel P, Rettig R, Mägi R, Biffar R, Schmidt R, Middelberg RP, Carroll RJ, Penninx BW, Scott RJ, Katz R, Sedaghat S, Wild SH, Kardia SL, Ulivi S, Hwang SJ, Enroth S, Kloiber S, Trompet S, Stengel B, Hancock SJ, Turner ST, Rosas SE, Stracke S, Harris TB, Zeller T, Zemunik T, Lehtimäki T, Illig T, Aspelund T, Nikopensius T, Esko T, Tanaka T, Gyllensten U, Völker U, Emilsson V, Vitart V, Aalto V, Gudnason V, Chouraki V, Chen WM, Igl W, März W, Koenig W, Lieb W, Loos RJ, Liu Y, Snieder H, Pramstaller PP, Parsa A, O'Connell JR, Susztak K, Hamet P, Tremblay J, de Boer IH, Böger CA, Goessling W, Chasman DI, Köttgen A, Kao WH, Fox CS. Genetic associations at 53 loci highlight cell types and biologica pathways relevant for kidney function. Nat Commun. 2016 Jan 21;7; PubMed PMID: 26831199; PubMed Central PMCID: PMC4735748

450. Clapham KR, Chu AY, Wessel J, Natarajan P, Flannick J, Rivas MA, Sartori S, Mehran R, Baber U, Fuster V, Scott RA, Rader DJ, Boehnke M, McCarthy MI, Altshuler DM, Kathiresan S, Peloso GM. A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. BMC Endocr Disord. 2016 Jan 28;16(1):7. PubMed PMID: 26822414; PubMed Central PMCID: PMC4730725

451. Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Felix JF, Young R, Shah N, Samuel M, Sheikh N, Mucksavage ML, Shah O, Li J, Morley M, Laser A, Mallick NH, Zaman KS, Ishaq M, Rasheed SZ, Memon FU, Ahmed F, Hanif B, Lakhani MS, Fahim M, Ishaq M, Shardha NK, Ahmed N, Mahmood K, Iqbal W, Akhtar S, Raheel R, O'Donnell CJ, Hengstenberg C, März W, Kathiresan S, Samani N, Goel A, Hopewell JC, Chambers J, Cheng YC, Sharma P, Yang Q, Rosand J, Boncoraglio GB, Kazmi SU, Hakonarson H, Köttgen A, Kalogeropoulos A, Frossard P, Kamal A, Dichgans M, Cappola T, Reilly MP, Danesh J, Rader DJ, Voight BF, Saleheen D. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. J Am Coll Cardiol. 2016 Feb 2;67(4):407-16. PubMed PMID: 26821629

452. Voight BF, Rader DJ. Human genetics shines a light on ischaemic stroke. Lancet Neurol. 2016 Feb;15(2):130-131.PubMed PMID: 26708677

453. Nurnberg ST, Zhang H, Hand NJ, Bauer RC, Saleheen D, Reilly MP, Rader DJ. From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circ Res. 2016 Feb 19;118(4):586-606. PubMed PMID: 26892960

454. Reyes-Soffer G, Millar JS, Ngai C, Jumes P, Coromilas E, Asztalos B, Johnson-Levonas AO, Wagner JA, Donovan DS, Karmally W, Ramakrishnan R, Holleran S, Thomas T, Dunbar RL, deGoma EM, Rafeek H, Baer AL, Liu Y, Lassman ME, Gutstein DE, Rader DJ, Ginsberg HN. Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein. Arterioscler Thromb Vasc Biol. 2016 Mar 10. PubMed PMID: 26966279; PubMed Central PMCID: PMC4911016

455. Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S,


Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 Mar 11;351(6278):1166-71. PubMed PMID: 26965621; PubMed Central PMCID: PMC4889017

456. Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med. 2016 Mar 24;374(12):1134-44. PubMed PMID: 26934567

457. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 1;126(4):1323-36PubMed PMID: 26950419

458. Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2016 Apr 1;126(4):1603-4. PubMed PMID: 27035815; PubMed Central PMCID: PMC4811110

459. Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ. Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol. Cardiovasc Res. 2016 May 1;110(1):23-9. PubMed PMID: 26786161; PubMed Central PMCID: PMC4798044

460. Kastelein JJ, Nissen SE, Rader DJ, Hovingh GK, Wang MD, Shen T, Krueger KA. Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study. Eur Heart J. 2016 May 1;37(17):1360-9. PubMed PMID: 26757788 PMCID: PMC4852062

461. Nioi P, Sigurdsson A, Thorleifsson G, Helgason H, Agustsdottir AB, Norddahl GL, Helgadottir A, Magnusdottir A, Jonasdottir A, Gretarsdottir S, Jonsdottir I, Steinthorsdottir V, Rafnar T, Swinkels DW, Galesloot TE, Grarup N, Jørgensen T, Vestergaard H, Hansen T, Lauritzen T, Linneberg A, Friedrich N, Krarup NT, Fenger M, Abildgaard U, Hansen PR, Galløe AM, Braund PS, Nelson CP, Hall AS, Williams MJ, van Rij AM, Jones GT, Patel RS, Levey AI, Hayek S, Shah SH, Reilly M, Eyjolfsson GI, Sigurdardottir O, Olafsson I, Kiemeney LA, Quyyumi AA, Rader DJ, Kraus WE, Samani NJ, Pedersen O, Thorgeirsson G, Masson G, Holm H, Gudbjartsson D, Sulem P, Thorsteinsdottir U, Stefansson K. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease. N Engl J Med. 2016 Jun 2;374(22):2131-41. PubMed PMID: 27192541

462. deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW. Treatment Gaps in Adults with Heterozygous Familial Hypercholesterolemia in the United States: Data from the CASCADE-FH Registry. Circ Cardiovasc Genet. 2016 Jun;9(3):240-9. PubMed PMID: 27013694

463. Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 Jun 7;67(22):2578-89. PubMed PMID: 27050191

464. Peloso GM, Rader DJ, Gabriel S, Kathiresan S, Daly MJ, Neale BM. Phenotypic extremes in rare variant study designs. Eur J Hum Genet. 2016 Jun;24(6):924-30. PubMed PMID: 26350511 PMCID: PMC4867440


465. Patel AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N, Boehnke M, Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, Kathiresan S. Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. Atherosclerosis. 2016 Jul;250:63-8. PubMed PMID: 27182959; PubMed Central PMCID: PMC4907838

466. Lin J, Hu Y, Nunez S, Foulkes AS, Cieply B, Xue C, Gerelus M, Li W, Zhang H, Rader DJ, Musunuru K, Li M, Reilly MP. Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1434-47. PubMed PMID: 27230130; PubMed Central PMCID: PMC4919157

467. Daugherty A, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C. Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1303-4. PubMed PMID: 27335467

468. Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, Iqbal J, Chan RB, Abramowicz S, Tascau L, Takiguchi S, Yamashita S, Welch CL, Di Paolo G, Hussain MM, Lefkowitch JH, Rader DJ, Tall AR. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016 Jul 6;535(7611):303-7. PubMed PMID: 27383786; PubMed Central PMCID: PMC4947007

469. Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WR. Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet. 2016 Jul 15;25(14):3042-3054. PubMed PMID: 27270415

470. Herzog E, Pragst I, Waelchli M, Gille A, Schenk S, Mueller-Cohrs J, Diditchenko S, Zanoni P, Cuchel M, Seubert A, Rader DJ, Wright SD. Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. J Appl Toxicol. 2016 Aug;36(8):1038-47. PubMed PMID: 26651060

471. Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ. Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metab. 2016 Aug 9;24(2):234-45. PubMed PMID: 27508872

472. Saleheen D, Rader DJ, Voight BF. Disentangling the Causal Association of Plasma Lipid Traits and Type 2 Diabetes Using Human Genetics. JAMA Cardiol. 2016 Sep 1;1(6):631-3 PubMed PMID: 27487162

473. Ginsberg HN, Rader DJ, Raal FJ, Guyton JR, Baccara-Dinet MT, Lorenzato C, Pordy R, Stroes E. Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher. Cardiovasc Drugs Ther. 2016 Oct;30(5):473-483. PubMed PMID: 27618825; PubMed Central PMCID: PMC5055560

474. Stroes E, Guyton JR, Lepor N, Civeira F, Gaudet D, Watts GF, Baccara-Dinet MT, Lecorps G, Manvelian G, Farnier M; ODYSSEY CHOICE II Investigators. Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study. J Am Heart Assoc. 2016 Sep 13;5(9). PubMed PMID: 27625344

475. van Capelleveen JC, Kastelein JJ, Zwinderman AH, van Deventer SJ, Collins HL, Adelman SJ, Round P, Ford J, Rader DJ, Hovingh GK. Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses. J Clin Lipidol. 2016 Sep-Oct;10(5):1137-1144.e3. PubMed PMID: 27678430

476. Ahmad ZS, Andersen RL, Andersen LH, O'Brien EC, Kindt I, Shrader P, Vasandani C,


Newman CB, deGoma EM, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Kullo IJ, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW. US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol. 2016 Sep-Oct;10(5):1223-9 PubMed PMID: 27678440

477. Beheshtian A, Shitole SG, Segal AZ, Leifer D, Tracy RP, Rader DJ, Devereux RB, Kizer JR. Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults. Atherosclerosis. 2016 Oct;253:47-53 PubMed PMID: 27575936

478. Roth EM, Moriarty PM, Bergeron J, Langslet G, Manvelian G, Zhao J, Baccara-Dinet MT, Rader DJ; ODYSSEY CHOICE I investigators. A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I. Atherosclerosis. 2016 Nov;254:254-262 PubMed PMID: 27639753

479. Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger P, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, Starling R, Ikle D, Christie J, Rame JE, Goldberg LR, Billheimer J, Rader DJ. Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2016 Nov;35(11):1295-1302. PubMed PMID: 27498384

480. Mansouri B, Kivelevitch D, Natarajan B, Joshi AA, Ryan C, Benjegerdes K, Schussler JM, Rader DJ, Reilly MP, Menter A, Mehta NN. Comparison of Coronary Artery Calcium Scores Between Patients With Psoriasis and Type 2 Diabetes. JAMA Dermatol. 2016 Nov 1;152(11):1244-1253. PubMed PMID: 27556410

481. Joshi AA, Lerman JB, Aberra TM, Afshar M, Teague HL, Rodante JA, Krishnamoorthy P, Ng Q, Aridi TZ, Salahuddin T, Natarajan B, Lockshin BN, Ahlman MA, Chen MY, Rader DJ, Reilly MP, Remaley AT, Bluemke DA, Playford MP, Gelfand JM, Mehta NN. GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis. Circ Res. 2016 Nov 11;119(11):1242-1253. PubMed PMID: 27654120; PubMed Central PMCID: PMC5215065

482. Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, Schminke U, Stitziel NO, Tada H, van Setten J, Smith AV, Vojinovic D, Yanek LR, Yao J, Yerges-Armstrong LM, Amin N, Baber U, Borecki IB, Carr JJ, Chen YI, Cupples LA, de Jong PA, de Koning H, de Vos BD, Demirkan A, Fuster V, Franco OH, Goodarzi MO, Harris TB, Heckbert SR, Heiss G, Hoffmann U, Hofman A, Išgum I, Jukema JW, Kähönen M, Kardia SL, Kral BG, Launer LJ, Massaro J, Mehran R, Mitchell BD, Mosley TH Jr, de Mutsert R, Newman AB, Nguyen KD, North KE, O'Connell JR, Oudkerk M, Pankow JS, Peloso GM, Post W, Province MA, Raffield LM, Raitakari OT, Reilly DF, Rivadeneira F, Rosendaal F, Sartori S, Taylor KD, Teumer A, Trompet S, Turner ST, Uitterlinden AG, Vaidya D, van der Lugt A, Völker U, Wardlaw JM, Wassel CL, Weiss S, Wojczynski MK, Becker DM, Becker LC, Boerwinkle E, Bowden DW, Deary IJ, Dehghan A, Felix SB, Gudnason V, Lehtimäki T, Mathias R, Mook-Kanamori DO, Psaty BM, Rader DJ, Rotter JI, Wilson JG, van Duijn CM, Völzke H, Kathiresan S, Peyser PA, O'Donnell CJ; CHARGE Consortium. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520. PubMed PMID: 27872105

483. Quach D, Vitali C, La FM, Xiao AX, Millar JS, Tang C, Rader DJ, Phillips MC, Lyssenko NN. Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1968-1979. PubMed PMID: 27671775

484. Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl


J Med. 2016 Dec 15;375(24):2349-2358. PubMed PMID: 27959714; PubMed Central PMCID: PMC5338864

485. Jacoby DS, Rader DJ. Improving cardiovascular outcomes by intensifying low density lipoprotein lowering therapy in high-risk patients. Eur Heart J. 2016 Dec 21;37(48):3585-3587 PubMed PMID: 27742811

486. Rader DJ, Damrauer SM. "Pheno"menal value for human health. Science. 2016 Dec 23;354(6319):1534-1536. PubMed PMID: 28008030

487. Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S; CHARGE–Heart Failure Consortium.; CARDIoGRAM Exome Consortium. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol. 2016 Dec 27;68(25):2761-2772. PubMed PMID: 28007139; PubMed Central PMCID: PMC5328146

488. Small AM, Mehta NN, Rader DJ. The Role of Emerging Biomarkers in Unraveling the Complex Biology Underlying Associations between HDL Cholesterol and Cardiovascular Diseases. Clin Chem. 2017 Jan;63(1):27-29. PubMed PMID: 27815309

489. Chhatriwalla AK, Rader DJ. Intracoronary Imaging, Reverse Cholesterol Transport, and Transcriptomics: Precision Medicine in CAD? J Am Coll Cardiol. 2017 Feb 14;69(6):641-643. PubMed PMID: 28183507

490. Rader DJ. Mediterranean Approach to Improving High-Density Lipoprotein Function. Circulation. 2017 Feb 14;135(7):644-647. PubMed PMID: 28193798

491. Rader DJ, Bajaj A, Khetarpal SA. Deep Apolipoprotein Proteomics to Uncover Mechanisms of Coronary Disease Risk. J Am Coll Cardiol. 2017 Feb 21;69(7):801-804. PubMed PMID: 28209221

492. Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M; Wellcome Trust Case Control Consortium., Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J; MORGAM Investigators., Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ, Schunkert H, Deloukas P, Kathiresan S; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol. 2017 Feb 21;69(7):823-836. PubMed PMID: 28209224; PubMed Central PMCID: PMC5314135

493. Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM. Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR(+/-) Rhesus Macaques. Hum Gene Ther Clin Dev. 2017 Mar;28(1):39-50.PubMed PMID: 28319449


494. Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM. Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia. Hum Gene Ther Clin Dev. 2017 Mar;28(1):28-38. PubMed PMID: 28319445

495. Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S; Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium. Association of Rare andCommon Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 Mar 7;317(9):937-946. PMID: 28267856

496. Emdin CA, Khera AV, Natarajan P, Klarin D, Baber U, Mehran R, Rader DJ, Fuster V, Kathiresan S. Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. Am J Cardiol. 2017 Mar 15;119(6):881-885. PubMed PMID: 28061997

497. Bi X, Pashos EE, Cuchel M, Lyssenko NN, Hernandez M, Picataggi A, McParland J, Yang W, Liu Y, Yan R, Yu C, DerOhannessian SL, Phillips MC, Morrisey EE, Duncan SA, Rader DJ. ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. EBioMedicine. 2017 Apr;18:139-145. PubMed PMID: 28330813

498. Dunbar RL, Goel H, Tuteja S, Song WL, Nathanson G, Babar Z, Lalic D, Gelfand JM, Rader DJ, Grove GL. Measuring Physical Stigmata of Niacin-Associated Skin Toxicity by Colorimetry, White-Light Spectroscopy, Laser Doppler Flowmetry, and Thermometry in Combination with Symptom Perception Scoring: Methods to Aid Development of Niacin Mimetics. J Lipid Res. 2017 Apr;58(4):783-797. PubMed PMID: 28119443

499. Cuchel M, Raper AC, Conlon DM, Pryma DA, Freifelder RH, Poria R, Cromley D, Li X, Dunbar RL, French B, Qu L, Farver W, Su CC, Lund-Katz S, Baer A, Ruotolo G, Akerblad P, Ryan CS, Xiao L, Kirchgessner TG, Millar JS, Billheimer JT, Rader DJ. A Novel Approach to Measuring Macrophage-specific Reverse Cholesterol Transport in Vivo in Humans. J Lipid Res. 2017 Apr;58(4):752-762. PubMed PMID: 28167703

500. Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA. A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell. 2017 Apr 6;20(4):478-489.e5. PubMed PMID: 28388428; PubMed Central PMCID: PMC5385853

501. Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. J Lipid Res. 2017 Apr;58(4):731-741. PubMed PMID: 28137768

502. Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, Marchadier DH, Rogov P, Shi J, Slovik KJ, Stylianou IM, Wang L, Yan R, Zhang X, Kathiresan S, Duncan SA, Mikkelsen TS, Morrisey EE, Rader DJ, Brown CD, Musunuru K. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017 Apr 6;20(4):558-570.e10. PubMed PMID: 28388432

503. Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Khetarpal SA, Won HH, Karczewski KJ, O'Donnell-Luria AH, Samocha KE, Weisburd B, Gupta N, Zaidi M, Samuel M, Imran A, Abbas S, Majeed F, Ishaq M, Akhtar S, Trindade K, Mucksavage M, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SN, Memon A, Hayyat Mallick N, Ishaq M, Rasheed


SZ, Memon FU, Mahmood K, Ahmed N, Do R, Krauss RM, MacArthur DG, Gabriel S, Lander ES, Daly MJ, Frossard P, Danesh J, Rader DJ, Kathiresan S.Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 Apr 12;544(7649):235-239. PubMed PMID: 28406212

504. Ueda M, Dunbar RL, Wolska A, Sikora TU, Escobar MD, Seliktar N, deGoma E, DerOhannessian S, Morrell L, McIntyre AD, Burke F, Sviridov D, Amar M, Shamburek RD, Freeman L, Hegele RA, Remaley AT, Rader DJ. A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency with Severe Triglyceridemia and Pancreatitis. J Clin Endocrinol Metab. 2017 May 1;102(5):1454-1457. PubMed PMID: 28201738

505. Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth AS, Rader DJ, Ford I, Sattar N, Kathiresan S. Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting. Circulation. 2017 May 30;135(22):2091-2101. PubMed PMID: 28223407

506. Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, Shah SH, Yu B, Boerwinkle E, Rader DJ, Gupta N, Frossard PM, Rasheed A, Danesh J, Lander ES, Gabriel S, Saleheen D, Musunuru K, Kathiresan S; PROMIS and Myocardial Infarction Genetics Consortium Investigators: ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017 Apr 25;69(16):2054-2063. PMID: 28385496

507. Khera AV, Demler O, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S: Cholesterol Efflux Capacity, HDL Particle Number, and IncidentCardiovascular Events. An Analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20;135(25):2494-2504. PMID: 28450350

508. Mehta MB, Shewale SV, Sequeira RN, Millar JS, Hand NJ, Rader DJ. Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis. J Biol Chem. 2017 Jun 23;292(25):10444-10454. PubMed PMID: 28473467; PubMed Central PMCID: PMC5481556

509. Millar JS, Lassman ME, Thomas T, Ramakrishnan R, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Wagner JA, Holleran S, Obunike J, Liu Y, Aoujil S, Standiford T, Gutstein DE, Ginsberg HN, Rader DJ, Reyes-Soffer G. Effects of CETP Inhibition with Anacetrapib on Metabolism of VLDL TG and Plasma Apolipoproteins C-II, C-III, and E. J Lipid Res. 2017 Jun;58(6):1214-1220. PMID: 28314859

510. Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017 Jun 23;121(1):81-88.PubMed PMID: 28506971; PubMed Central PMCID: PMC5523940

511. Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, Abbas S, Majeed F, Akhtar S, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SN, Memon A, Mallick NH, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Frossard P, Tsimikas S, Witztum JL, Marcovina S, Sandhu M, Rader DJ, Danesh J. Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2017 Jul;5(7):524-533. PubMed PMID: 28408323

512. Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig LB,


Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers LJ, van Gorp RH, Ries C, Kusters PJH, van der Wal AC, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C: Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence from Mouse and Human Studies. Circulation. 2017 Jul 25;136(4):388-403. PMID: 28450349

513. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, R V R Horimoto A, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK, Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M, Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C, Macfarlane PW, Heilmann-Heimbach S, Almgren P, Huang PL, Sotoodehnia N, Soliman EZ, Uitterlinden AG, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ, Guo X; METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium, Dichgans M, Ingelsson E, Kooperberg C, Melander O, J F Loos R, Laurikka J, Conen D, Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A, Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ, Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT; AFGen Consortium. Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017 Jul 27;49(8):1286. PubMed PMID: 28747752

514. Blom DJ, Averna MR, Meagher EA, du Toit Theron H, Sirtori CR, Hegele RA, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Larrey D, Bloedon LT, Foulds P, Rader DJ, Cuchel M. Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation. 2017 Jul 18;136(3):332-335. PubMed PMID: 28716835

515. Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, Lopez A, Penn J, Zhao A, Shao W, Stahl N, Murphy AJ, Hamon S, Bouzelmat A, Zhang R, Shumel B, Pordy R, Gipe D, Herman GA, Sheu WHH, Lee IT, Liang KW, Guo X, Rotter JI, Chen YI, Kraus WE, Shah SH, Damrauer S, Small A, Rader DJ, Wulff AB, Nordestgaard BG, Tybjærg-Hansen A, van den Hoek AM, Princen HMG, Ledbetter DH, Carey DJ, Overton JD, Reid JG, Sasiela WJ, Banerjee P, Shuldiner AR, Borecki IB, Teslovich TM, Yancopoulos GD, Mellis SJ, Gromada J, Baras A. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. N Engl J Med. 2017 Jul 20;377(3):211-221. PubMed PMID: 28538136

516. Thomas T, Zhou H, Karmally W, Ramakrishnan R, Holleran S, Liu Y, Jumes P, Wagner JA, Hubbard B, Previs SF, Roddy T, Johnson-Levonas AO, Gutstein DE, Marcovina SM, Rader DJ, Ginsberg HN, Millar JS, Reyes-Soffer G. CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects. Arterioscler Thromb Vasc Biol. 2017 Jul 20. PubMed PMID: 28729361


517. Knowles JW, Rader DJ, Khoury MJ. Cascade Screening for Familial Hypercholesterolemia and the Use of Genetic Testing. JAMA. 2017 Jul 25;318(4):381-382. PubMed PMID: 28742895

518. Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF, Fauman EB, Salfati EL, Sun BB, Eicher JD, Johnson AD, Sheu WHH, Nielsen SF, Lin WY, Surendran P, Malarstig A, Wilk JB, Tybjærg-Hansen A, Rasmussen KL, Kamstrup PR, Deloukas P, Erdmann J, Kathiresan S, Samani NJ, Schunkert H, Watkins H; CARDIoGRAMplusC4D, Do R, Rader DJ, Johnson JA, Hazen SL, Quyyumi AA, Spertus JA, Pepine CJ, Franceschini N, Justice A, Reiner AP, Buyske S, Hindorff LA, Carty CL, North KE, Kooperberg C, Boerwinkle E, Young K, Graff M, Peters U, Absher D, Hsiung CA, Lee WJ, Taylor KD, Chen YH, Lee IT, Guo X, Chung RH, Hung YJ, Rotter JI, Juang JJ, Quertermous T, Wang TD, Rasheed A, Frossard P, Alam DS, Majumder AAS, Di Angelantonio E, Chowdhury R; EPIC-CVD, Chen YI, Nordestgaard BG, Assimes TL, Danesh J, Butterworth AS, Saleheen D. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat Genet. 2017 Jul;49(7):1113-1119. PubMed PMID:28530674

519. Tuteja S, Wang L, Dunbar RL, Chen J, DerOhannessian S, Marcovina SM, Elam M, Lader E, Rader DJ. Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy. Pharmacogenet Genomics. 2017 Aug;27(8):285-293. PubMed PMID: 28628560

520. Small AM, Kiss DH, Zlatsin Y, Birtwell DL, Williams H, Guerraty MA, Han Y, Anwaruddin S, Holmes JH, Chirinos JA, Wilensky RL, Giri J, Rader DJ. Text mining applied to electronic cardiovascular procedure reports to identify patients with trileaflet aortic stenosis and coronary artery disease. J Biomed Inform. 2017 Aug;72:77-84. PubMed PMID: 28624641

521. Dunbar RL, Movva R, Bloedon LT, Duffy D, Norris RB, Navab M, Fogelman AM, Rader DJ. Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. Clin Transl Sci. 2017 Aug 9. Epub ahead of print PubMed PMID: 28795506

522. Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader DJ. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med. 2017 Aug 21. Epub ahead of print. PubMed PMID: 28825717

523. Bajaj A, Damrauer SM, Anderson AH, Xie D, Budoff MJ, Go AS, He J, Lash JP, Ojo A, Post WS, Rahman M, Reilly MP, Saleheen D, Townsend RR, Chen J, Rader DJ. Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort). Arterioscler Thromb Vasc Biol. 2017 Aug 24. Epub ahead of print. PubMed PMID: 28838919

524. Koekemoer AL, Codd V, Masca NGD, Nelson CP, Musameh MD, Kaess BM, Hengstenberg C, Rader DJ, Samani NJ. Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity. Arterioscler Thromb Vasc Biol. 2017 Aug 31. Epub ahead of print. PubMed PMID: 28860221

525. Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S, Imamura M, Yamauch T, Chambers JC, Chen P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas S, Majeed F, Trindade K, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielsen SF, Nordestgaard BG, Tybjaerg-Hansen A, Young R; CHD Exome+ Consortium, Benn M, Frikke-Schmidt R, Kamstrup PR; EPIC-CVD Consortium; EPIC-Interact Consortium; Michigan Biobank, Jukema JW, Sattar N, Smit R,


Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa V, Rader DJ, Danesh J, Voight BF, Saleheen D. Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat Genet. 2017 Sep 4. Epub ahead of print. PubMed PMID: 28869590

526. Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre AD, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA. Polygenic determinants in extremes of high-density lipoprotein cholesterol. J Lipid Res. 2017 Sep 4. Epub ahead of print. PubMed PMID: 28870971

Peer-reviewed Review Articles and Editorials

1. Schaefer JR, Rader DJ, Brewer HB Jr. Investigation of lipoprotein kinetics using endogenous labeling with stable isotopes. Current Opinion in Lipidology 3:227-232; 1992

2. Rader DJ and Brewer HB Jr. Lipoprotein(a). Clinical approach to a unique atherogenic lipoprotein. JAMA 267:1109-1112; 1992

3. Rader DJ, Brewer HB Jr. Abetalipoproteinemia: New insights into lipoprotein assembly and vitamin E metabolism from a rare genetic disease. JAMA 270:865-869; 1993

4. Rader DJ, Hoeg JM, Brewer HB Jr. Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease. Ann Int Med 120:1012-1025; 1994

5. Rader DJ, Ikewaki K. Unravelling high-density lipoprotein-apolipoprotein metabolism in human mutants and animal models. Curr Opin Lipidology 7:117-123; 1996

6. Rader DJ, FitzGerald GA. State of the art: Atherosclerosis in a limited edition. Nature Medicine 4:899-900; 1998

7. Rader DJ. Gene therapy for atherosclerosis. Molecular Therapeutics 1:680-689; 1998. 8. Rumberger JA. Brundage BH. Rader DJ. Kondos G. Electron beam computed tomographic

coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clinic Proceedings. 74:243-52, 1999

9. Rader DJ, Meagher E. Lipid lowering drug therapy in primary prevention: who should be treated? Preventive Cardiology 2:105-114, 1999

10. Rader DJ. Noninvasive procedures for subclinical atherosclerosis risk assessment. American Journal of Medicine 107:25S-27S, 1999

11. Hobbs HH, Rader DJ. ABC1: connecting yellow tonsils, neuropathy, and very low HDL. J Clin Invest 104:1015-1018; 1999

12. Rader DJ, Maugeais C. Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention. Molecular Medicine Today 6:170-175; 2000.

13. Rader DJ and Jaye M. Endothelial lipase: a new member of the triglyceride lipase gene family. Curr Opin Lipidology 11:141-148; 2000

14. Rader DJ and Pure’ E. Genetic susceptibility to atherosclerosis: insights from mice. Circulation Research 86:1013-1015; 2000

15. Kawashiri M, Maugeais C, Rader DJ. High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis. Curr Atherosclerosis Reports 2:363-372; 2000

16. Rader DJ, Dugi KA. The endothelium and lipoproteins: insights from recent cell biology and animal studies. Seminars in Thrombosis and Hemostasis 26:521-528; 2000.

17. Dugi KA, Rader DJ. The endothelium and lipoproteins: a clinical perspective. Seminars in Thrombosis and Hemostasis 26:529-536; 2000

18. Rader DJ. Inflammatory markers of coronary risk. New Engl J Med 343:1179-1182; 2000. 19. Thompson PD, Rader DJ. Does exercise increase HDL cholesterol in those who need it the

most? Arterio Thromb Vasc Biol. 21: 1097-1098: 2001


20. Grundy SM, D’Agostino RB, Mosca L, Burke GL, Wilson PWF, Rader DJ, Cleeman JI, Roccella EJ, Cutler JA, Friedman LM. Cardiovascular risk assessment based on US cohort studies. Circulation 104: 491-496: 2001

21. Rader DJ. A new feature on the cholesterol-lowering landscape. Nature Med. 7: 1282-1284: 2001

22. Jin W, Marchadier D, Rader DJ. Lipases and HDL metabolism. Trends in Endo & Metab 13: 174-178; 2002

23. Epstein JA, Rader DJ, Parmacek MS. Cardiovascular disease in the postgenomic era – lessons learned and challenges ahead. Endocrinology: 143: 1-6: 2002

24. Rader DJ. High-density lipoproteins and atherosclerosis. Am J Cardiol: 90 (suppl.):62I-70I; 2002

25. Barter PJ, Brewer HB Jr, Chapman MJ, Hennekens CH, Rader DJ, Tall AR. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol 23:160-7; 2003

26. Rosas S, Szapary P, Rader DJ. Management of selected lipid abnormalities: hypertriglyceridemia, isolated low HDL-cholesterol, lipoprotein(a), and lipid abnormalities in renal diseases and following solid organ transplantation. Cardiol Clin. 2003 Aug;21(3):377-92. Review. PubMed PMID: 14621452.

27. Rader DJ. Interrelationships between the metabolic syndrome, inflammation, and HDL metabolism. Cardiology Review 20: 12-15; 2003

28. Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest 111: 1795-1803; 2003

29. Jacoby DS, Rader DJ. Renin-angiotensin system and atherothrombotic disease: from genes to treatment. Arch Intern Med 163: 1155-1164; 2003

30. Rader DJ. Therapy to reduce risk of coronary heart disease. Clin Cardiol 26: 2-8; 2003 31. Reilly MP, Rader DJ. The metabolic syndrome: more than the sum of its parts? Circulation

108: 1546-51; 2003 32. Rader DJ. Regulation of reverse cholesterol transport and clinical implications. Am J Cardiol

92: 42J-49J; 2003 33. Rader DJ. High-density lipoproteins as an emerging therapeutic target for atherosclerosis.

JAMA 290:2322-2324: 2003 34. Cuchel M, Rader DJ. Genetics of increased HDL cholesterol levels: insights into the

relationship between HDL metabolism and atherosclerosis. Arterio Thromb Vasc Biol 23:1710-1712; 2003

35. Jacoby DS, Mohler III ER, Rader DJ. Noninvasive atherosclerosis imaging for predicting cardiovascular events and assessing therapeutic interventions. Curr Atheroscler Rep 6:20-6; 2004

36. Wolfe ML, Rader DJ. Cholesteryl ester transfer protein and coronary artery disease: an observation with therapeutic implications. Circulation 110:1338-40; 2004

37. Rader DJ. Inhibition of cholesteryl ester transfer protein activity: a new therapeutic approach to raising high-density lipoprotein. Curr Atheroscler Rep. 2004 Sep;6(5):398-405. Review. PubMed PMID: 15296707.

38. Szapary PO, Rader DJ. The triglyceride-high-density lipoprotein axis: an important target of therapy? Am Heart J 148:211-21; 2004

39. Badellino KO, Rader DJ. The role of endothelial lipase in high-density lipoprotein metabolism. Curr Opin Cardiol 19:392-5; 2004

40. Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA. An Inflammatory Cascade Leading to Hyperresistinemia in Humans. PLoS Med. 2004 Nov;1(2):e45. Review. PubMed PMID: 15578112; PubMed Central PMC529430

41. Broedl UC, Jin W, Rader DJ. Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation. Trends Cardiovasc Med 14:202-6; 2004


42. Rader DJ. Novel approaches to the treatment of dyslipidemia. Arterio Thromb Vasc Bio 25:480-81; 2005

43. Rader DJ. Gene therapy for genetic lipid disorders: lipoprotein lipase deficiency as a paradigm. Neth J Med 63:2-3; 2005

44. Duffy D, Rader DJ. Drugs in development: targeting high-density lipoprotein metabolism and reverse cholesterol transport. Curr Opin Cardiol 20:301-306; 2005

45. Lewis GF, Rader DJ. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res 96:1221-32; 2005

46. Rader DJ, Pure’ E. Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell? Cell Metab 1:223-230; 2005

47. Rader DJ. Gain-of-function mutations and therapeutic implications: lipoprotein lipase S447X to the rescue. Arterio Throm Vasc Biol. 25:2018-9; 2005

48. Duffy D, Rader DJ. Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport. Circulation 113:1140-1150; 2006

49. Duffy D, Rader DJ. High-density lipoprotein cholesterol therapies: the next frontier in lipid management. J Cardiopulm Rehabil 26:1-8; 2006

50. Reilly M, Rader DJ. Apolipoprotein E and coronary disease: a puzzling paradox. PLoS Med 3:e258; 2006

51. Cuchel M, Rader DJ. Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation 113:2548-2555; 2006

52. Qasim A, Rader DJ. Human genetics of variation in high-density lipoprotein cholesterol. Curr Athero Rep 8:198-205; 2006

53. Budoff MJ, Achenbach S, Blumenthal RS, Carr JJ, Goldin JG, Greenland P, Guerci AD, Lima JA, Rader DJ, Rubin GD, Shaw LJ, Wiegers SE. Assessment of Coronary Artery Disease by Cardiac Computed Tomography, A Scientific Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation. 114:1761-91; 2006.

54. Rader DJ. Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest. 116:3090-100; 2006

55. Rader DJ. Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med. 2007 Mar;120(3 Suppl 1):S12-8. Review. PubMed PMID: 17320517

56. Rader DJ. Mechanisms of disease: HDL metabolism as a target for novel therapies. Nat Clin Pract Cardiovasc Med. 4:102-9; 2007

57. Wang X, Rader DJ. Molecular regulation of macrophage reverse cholesterol transport. Curr Opin Cardiol. 22:368-72; 2007

58. Lilly SM, Rader DJ. New targets and emerging therapies for reducing LDL cholesterol. Curr Opin Lipidol. 18(6):650-5; 2007

59. Cuchel M, Rader DJ. Is the cholesteryl ester transfer protein proatherogenic or antiatherogenic in humans? J Am Coll Cardiol. 50:1956-8; 2007

60. Rader DJ. Illuminating HDL--is it still a viable therapeutic target? N Engl J Med.357:2180-3; 2007

61. Rader DJ, Ischiropoulos H. Multipurpose oxidase in atherogenesis. Nat Med. 13(10):1146-7; 2007

62. Glassberg H, Rader DJ. Management of Lipids in the Prevention of Cardiovascular Events. Annu Rev Med. 18;59:79-94; 2008

63. deGoma EM, deGoma RL, Rader DJ. Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol. 51:2199-211; 2008




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64. Edmondson AC, Rader DJ. Genome-wide approaches to finding novel genes for lipid traits: the start of a long road. Circ Cardiovasc Genet. 1(1):3-6; 2008

65. Rader DJ, Daugherty A. Translating molecular discoveries into new therapies for atherosclerosis. Nature. 451:904-913; 2008

66. Movva R, Rader DJ. Laboratory assessment of HDL heterogeneity and function. Clin Chem. 54(5):788-800; 2008

67. Hunter DJ, Altshuler D, Rader DJ. From Darwin's finches to canaries in the coal mine--mining the genome for new biology. N Engl J Med. 358(26):2760-3; 2008

68. Brown RJ, Rader DJ. When HDL gets fat... Circ Res. 103(2):131-2; 2008 69. Neeli H, Rader DJ. Cholesteryl ester transfer protein (CETP) inhibitors: is there life after

torcetrapib? Cardiol Clin. 26(4):537-46; 2009 70. Rader DJ, Alexander ET, Weibel GL, Billheimer J, Rothblat GH. The role of reverse

cholesterol transport in animals and humans and relationship to atherosclerosis. J Lipid Res. 50 Suppl:S189-94; 2009

71. Rader DJ. Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesn't quite follow the script. Circulation 120(7):549-52; 2009

72. Khera AV, Rader DJ. Discovery and validation of new molecular targets in treating dyslipidemia: the role of human genetics. Trends Cardiovasc Med. 19(6):195-201; 2009

73. Duffy D, Rader DJ. Update on strategies to increase HDL quantity and function. Nat Rev Cardiol. 6(7):455-63; 2009

74. Burke MF, Khera AV, Rader DJ. Polyphenols and cholesterol efflux: is coffee the next red wine? Circ Res. 106(4):627-9; 2010

75. Burke MF, Dunbar RL, Rader DJ. Could exercise metabolomics pave the way for gymnomimetics? Science Transl Med.; 2(41):41ps35; 2010

76. Farouk SS, Rader DJ, Reilly MP, Mehta NN. CXCL12: A New Player in Coronary Disease Identified through Human Genetics. Trends Cardiovasc Med. 20(6):204-9; 2010.

77. Degoma EM, Rader DJ. Novel HDL-directed pharmacotherapeutic strategies. Nat Rev Cardiol. 8(5):266-77; 2011

78. Bauer RC, Stylianou IM, Rader DJ. Functional validation of new pathways in lipoprotein metabolism identified by human genetics. Curr Opin Lipidol. 22(2):123-8; 2011

79. Goldberg AC, Hopkins PN, Toth PP, Ballantyne CM, Rader DJ, Robinson JG, Daniels SR, Gidding SS, de Ferranti SD, Ito MK, McGowan MP, Moriarty PM, Cromwell WC, Ross JL, Ziajka PE. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol. May-Jun;5(3):133-40; 2011

80. Goldberg AC, Hopkins PN, Toth PP, Ballantyne CM, Rader DJ, Robinson JG, Daniels SR, Gidding SS, de Ferranti SD, Ito MK, McGowan MP, Moriarty PM, Cromwell WC, Ross JL, Ziajka PE; National Lipid Association Expert Panel on Familial Hypercholesterolemia. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol. Jun;5(3 Suppl):S1-8; 2011

81. Hopkins PN, Toth PP, Ballantyne CM, Rader DJ; National Lipid Association Expert Panel on Familial Hypercholesterolemia. Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol. Jun;5(3 Suppl):S9-17; 2011

82. Mehta NN, Li M, William D, Khera AV, DerOhannessian S, Qu L, Ferguson JF, McLaughlin C, Shaikh LH, Shah R, Patel PN, Bradfield JP, He J, Stylianou IM, Hakonarson H, Rader DJ, Reilly MP. The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur Heart J. 2011 Apr;32(8):963-71. Review. PubMed PMID: 21415067; PubMed Central PMCID: PMC3076669

































83. Degoma EM, Knowles JW, Angeli F, Budoff MJ, Rader DJ. The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease. Cardiol Rev. May-Jun;20(3):118-29; 2012

84. Rak K, Rader DJ. Cardiovascular disease: the diet-microbe morbid union. Nature. 472(7341):40-1; 2011

85. Mehta NN, Rader DJ. Fluorescent green plaques: light at the end of the catheter? Cell Metab. 14(1):7-8; 2011

86. McGillicuddy FC, Reilly MP, Rader DJ. Adipose modulation of high-density lipoprotein cholesterol: implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease. Circulation. 124(15):1602-5; 2011

87. Rader DJ. IL-1 and atherosclerosis: a murine twist to an evolving human story. J Clin Invest. 2012 Jan 3;122(1):27-30. PMID: 22201674 PMCID: PMC3248309

88. Stylianou IM, Bauer RC, Reilly MP, Rader DJ. Genetic basis of atherosclerosis: insights from mice and humans. Circ Res. 20;110(2):337-55; 2012

89. Rosenson RS, Brewer HB Jr, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L. Circulation. 17;125(15): 1905-19; 2012

90. Strong A, Rader DJ. Sortilin as a regulator of lipoprotein metabolism. Curr Atheroscler Rep. 14(3):211-8; 2012

91. deGoma EM, Rader DJ. High-density lipoprotein particle number: a better measure to quantify high-density lipoprotein? J Am Coll Cardiol. 2012 Aug 7;60(6):517-20. PubMed PMID: 22796252

92. Rader DJ, Tall AR. The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis? Nat Med. 2012 Sep;18(9):1344-6. PubMed PMID: 22961164

93. Rader DJ, deGoma EM. Approach to the patient with extremely low HDL-cholesterol. J Clin Endocrinol Metab. 2012 Oct;97(10):3399-407. PMCID: PMC3462950

94. McGowan MP, Underberg JA, Rader DJ. Improving outcomes in patients with severe familial hypercholesterolemia. J Clin Lipidol. 2012 Nov;6(6):S2-4. PubMed PMID: 23312060.

95. Qamar A, Rader DJ. Effect of interleukin 1β inhibition in cardiovascular disease. Curr Opin Lipidol. 2012 Dec;23(6):548-53. 10.1097/MOL.0b013e328359b0a6. PMID: 23069985

96. Agarwala A, Billheimer J, Rader DJ. Mighty minipig in fight against cardiovascular disease. Sci Transl Med. 2013 Jan 2;5(166):166fs1. PMID: 23283365

97. Cuchel M, Rader DJ. Lipid-lowering treatment for homozygous familial hypercholesterolaemia -- authors' reply. Lancet. 2013 Apr 6;381(9873):1183. PMID: 23561998

98. Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O'Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, Ginsburg GS. Implementing genomic medicine in the clinic: the future is here. Genet Med. 15(4):258-67; 2013

99. Master SR, Rader DJ. Beyond LDL Cholesterol in Assessing Cardiovascular Risk: apo B or LDL-P? Clin Chem. 2013 May;59(5):723-5. PMID: 23487171

100. Kahn ML, Rader DJ. Lymphatics as a new active player in reverse cholesterol transport. Cell Metab. 2013 May 7;17(5):627-8. PMID: 23663731

101. Cuchel M, Rader DJ. Microsomal transfer protein inhibition in humans. Curr Opin Lipidol. 2013 Jun;24(3):246-50. PMID: 23594709

102. Vickers KC, Rader DJ. Nuclear Receptors and microRNA-144 Coordinately Regulate Cholesterol Efflux. Circ Res. 2013 Jun 7;112(12):1529-31. PubMed PMID: 23743223

103. Khera AV, Rader DJ. Cholesterol efflux capacity: full steam ahead or a bump in the road? Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1449-51. PubMed PMID: 23766382












104. Brown WV, Rader DJ, Kane J. JCL Roundtable: Diagnosis of severe familial hypercholesterolemia. J Clin Lipidol. 7(6):540-5; 2013

105. Richardson K, Schoen M, French B, Umscheid CA, Mitchell MD, Arnold SE, Heidenreich PA, Rader DJ, Degoma EM. Statins and cognitive function: a systematic review. Ann Intern Med. 159(10):688-97; 2013

106. Javaheri A, Rader DJ. High-Density Lipoprotein: NO Failure in Heart Failure. Circ Res. 113(12):1275-7; 2013

107. Brown WV, Rader DJ, Goldberg AC. JCL Roundtable: Drug treatment of severe forms of familial hypercholesterolemia. J Clin Lipidol. 8(1):10-17; 2014

108. Rader DJ, Degoma EM. Future of cholesteryl ester transfer protein inhibitors. Annu Rev Med. 65:385-403; 2014

109. Javaheri A, Rader DJ, Javaheri S. Statin Therapy in Heart Failure: Is It Time for a Second Look? Hypertension. 2014 May;63(5):909-10 PMID: 24516102

110. Rader DJ. New Therapies for Coronary Artery Disease: Genetics Provides a Blueprint. Sci Transl Med. 2014 Jun 4;6(239):239ps4. Review. PubMed PMID: 24898745

111. HDL and cardiovascular disease. Rader DJ, Hovingh GK. Lancet. 2014 Aug16;384(9943) :618-25. PMID: 25131981

112. Khetarpal SA, Rader DJ. Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease. Biochim Biophys Acta. 2014 Oct;1842(10):2010-2020. PMID: 24931102

113. Rader DJ. New Therapeutic Approaches to the Treatment of Dyslipidemia. Cell Metab. 2016 Mar 8;23(3):405-12. Review. PMID: 26853751

114. Bauer RC, Khetarpal SA, Hand NJ, Rader DJ. Therapeutic Targets of Triglycerid Metabolism as Informed by Human Genetics. Trends Mol Med. 2016 Apr;22(4):328-40. Review. PubMed PMID: 26988439

115. Ajufo E, Rader DJ. Recent advances in the pharmacological management of hypercholesterolaemia. Lancet Diabetes Endocrinol. 2016 May;4(5):436-46. Review. PubMed PMID: 27012540

116. Khetarpal SA, Qamar A, Millar JS, Rader DJ. Targeting ApoC-III to Reduce Coronary Disease Risk. Curr Atheroscler Rep. 2016 Sep;18(9):54. PMID: 27443326

117. Small A, Kiss D, Giri J, Anwaruddin S, Siddiqi H, Guerraty M, Chirinos JA, Ferrari G, Rader DJ. Biomarkers of Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):623-632. Feb 2. Review. PubMed PMID: 28153876; PubMed Central PMCID: PMC5364059

Non-peer reviewed Reviews, Editorials, and Book Chapters

1. Schaefer JS, Rader DJ, Gregg RE, Fairwell T, Zech LA, Kindt MR, Benson MD, Brewer HB

Jr. In vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new approach to the study of mutant proteins in humans. Trans Assoc Am Physicians 103:187-194; 1990

2. Brewer HB Jr, Rader DJ, Fojo SS, Hoeg JM. Frontiers in the analysis of HDL structure, function, and metabolism. In: Disorders of HDL. Carlson LA (ed), Smith-Gordan, pp. 51-58; 1990

3. Brewer HB Jr, Rader DJ, Hoeg JM, Mann A, Tennyson G. Recent advances in lipoprotein metabolism and the genetic dyslipoproteinemias. Brewer HB Jr, Rader DJ, Hoeg JM, Mann A, Tennyson G. Adv Exp Med Biol. 1991;285:237-44. PMID: 1830448

4. Zech LA, Rader DJ, Greif PC. Berman's simulation analysis and modeling. Adv Exp Med Biol. 1991;285:188-99. PMID: 1858549

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5. Brewer HB Jr and Rader DJ. HDL: Structure, Function and Metabolism. Prog Lipid Res. 1991;30(2-3):139-44. PMID: 1823933

6. Rader DJ, Ikewaki K, Schaefer J, Brewer HB Jr. Metabolism of HDL particles LpA-I and LpA-I,A-II in normal and hyperalphalipoproteinemic subjects. In: Atherosclerosis Reviews: High density lipoproteins - Pathophysiology and clinical relevance. Catapano A, Bernini F, and Corsini A (eds), Raven Press, New York, New York, pp. 43-55; 1993

7. Rader DJ, Patterson A, Eggerman T, Hoeg JM, Brewer HB Jr. Apolipoprotein B mRNA editing: modulation and clinical implications. In: Hormones in lipoprotein metabolism. Steinmetz A (ed), Springer-Verlag, Heidelberg, Germany, pp. 17-21; 1993

8. Rader DJ and Brewer HB Jr. Lipids, Apolipoproteins, and Lipoproteins. In: Genetic Factors in Coronary Heart Disease. Goldbaurt U, de Faire U, Berg K (eds), Kluwer Academic Publishers, Dordrecht, The Netherlands; pp. 83-104; 1994

9. Rader DJ and Wilson JM. Gene Therapy for Lipid Disorders. In: Molecular Cardiovascular Medicine. Haber E (ed), Scientific American Medicine, New York; pp. 97-114; 1995

10. Rader DJ. Genetic Dyslipoproteinemias: Inborn Errors of Lipoprotein Metabolism. In: A Physician's Guide to the Laboratory Diagnosis of Inherited Metabolic Disease. Blau N, Duran M, Blaskovics M (eds), Chapman and Hall, London; 1996

11. Eder A, Rader DJ. LDL-Apheresis for severe refractory dyslipidemia. Today's Therapeutic Trends 14:165-179; 1996

12. Rader DJ, Raper SE, Wilson JM. Gene Therapy for Metabolic Disease. In: Diabetes Mellitus: A Fundamental and Clinical Text. LeRoith D, Olefsky J, Taylor S (eds), JB Lippincott Company, Philadelphia; pp. 432-437; 1996

13. Rader DJ. Disorders of Lipid Metabolism. In: Textbook of Internal Medicine. Kelley WN (ed), JB Lippincott Co., Philadelphia; pp. 72-89; 1996.

14. Rader DJ. Approaches to Hypercholesterolemia and Other Abnormal Lipid Profiles. In: Textbook of Internal Medicine. Kelley WN (ed), JB Lippincott Co., Philadelphia; pp. 183-191; 1996.

15. Rader DJ. Hark L, Burke F. Nutrition and Pathophysiology: Cardiovascular Disease. In: Medical Nutrition and Disease. Morrison G, Hark L (eds), Blackwell Science, Cambridge; pp. 175-203; 1996

16. Rader DJ, Wilson JM. Gene therapy for familial hypercholesterolemia. In: Gene Delivery Systems: a state-of-the-art review. OECD Documents, Paris, France 1996; pp. 229-236.

17. Rader DJ. Gene therapy for atherosclerosis. International Journal of Clinical and Laboratory Research 27:35-43; 1997

18. Tsukamoto K, Rader DJ. Gene therapy for atherosclerotic disease: future prospects. Cardiovascular Risk Factors 7:129-137; 1997

19. Rader DJ. Lipid Disorders. In: Cardiovascular Medicine. Topol EJ (ed), Lippincott-Raven, New York, NY; pp. 59-90; 1997

20. Rader DJ. Atherosclerosis, acute coronary events, and cholesterol-lowering: a new paradigm. Value in Health 1:101-104; 1998

21. Friedrich CA, Rader DJ. Management of Lipid Disorders. Rheumatic Disease Clinics of North America 25:1-11; 1999

22. Tershakovec AM, Rader DJ. Disorders of lipoprotein metabolism and transport. In: Nelson Textbook of Pediatrics. 16th edition. Behrman RE, Kliegman RM, Jenson HB (eds), WB Saunders, Philadelphia, PA; pp. 387-397; 1999

23. Rader DJ. Pathophysiology and management of low high-density lipoprotein cholesterol. The American Journal of Cardiology 83:22F-24F; 1999

24. Rader DJ, Haffner SM. Role of fibrates in the management of hypertriglyceridemia. The American Journal of Cardiology 83:30F-35F; 1999.

25. Rader DJ, Tietge U. Gene Therapy for Dyslipidemia. Current Atherosclerosis Reports 1:58-69; 1999


26. Gorelick PB, Sacco RL, Smith DB, Alberts M, Mustone-Alexander L, Rader DJ, Ross JL, Raps E, Ozer MN, Brass LM, Malone ME, Goldberg S, Booss J, Hanley DF, Toole JF, Greengold NL, Rhew DC. Prevention of a first stroke: a review of guidelines and a multidisciplinary consensus statement from the National Stroke Association. JAMA. 281:1112-20, 1999

27. Friedrich CA, Rader DJ. Homocysteine and Vascular Disease. Journal of Clinical Outcomes Management 6:37-42; 1999

28. Liang, BT, Rader DJ, Mao, CA. Reducing cardiovascular risk. In Geriatric Secrets, 2nd Edition. Forciea, MA, Lavizzo-Mourey, R, and Schwab, EP (eds). Hanley & Belfus, Inc., Philadelphia; pp. 70-76; 2000

29. Mohler ER, Delanty N, Rader DJ, Raps EC. Statins and cerebrovascular disease: plaque attack to prevent brain attack. Vasc Med 4:269-272; 2000

30. Rader DJ, Raper SE, Wilson JM. Gene Therapy for Metabolic Disease. In: Diabetes Mellitus: A Fundamental and Clinical Text. 2nd Edition. LeRoith D, Olefsky J, Taylor S (eds), JB Lippincott Company, Philadelphia; pp. 526-534; 2000

31. Rader DJ and Rosas S. Management of selected lipid abnormalities. Hypertriglyceridemia, low HDL cholesterol, lipoprotein(a), in thyroid and renal diseases, and post-transplantation. Med Clin North Am 84:43-61; 2000

32. Szapary PO and Rader DJ. Pharmacological management of high triglycerides and low high-density lipoprotein cholesterol. Curr Opin in Pharm 1:113-120; 2001

33. Reilly MP, Rader DJ. Clinical decision-making in the management of lipid disorders. Disease Management and Clinical Outcomes 3:30-37; 2001

34. Meagher E, Rader DJ. Antioxidant therapy and atherosclerosis: animal and human studies. Trends Cardiovasc Med. 11:162-5; 2001

35. Reilly MP and Rader DJ. Clinical decision-making in the management of lipid disorders. In: Disease Management & Clinical Outcomes 3:30-37; 2001

36. Cohen AM and Rader DJ. Dyslipidemia. In: Current Treatment Options in Cardiovascular Medicine 3:347-357; 2001

37. Cuchel M, Rader DJ. Cholesterol and all-cause mortality in Honolulu. The Lancet 358: 1903-1904: 2001 (letter)

38. Rader DJ. Gene therapy for familial hypercholesterolemia. Nutr Metab Cardiovasc Dis. Suppl 5:40-4; 2001

39. Cuchel M, Rader DJ. The role of high-density lipoproteins in thrombosis. The Scientific World. 2: 89-95: 2002

40. Rader DJ. Lipid Disorders. In: Cardiovascular Medicine. Topol EJ (2nd ed), Lippincott-Raven, New York, NY; pp 43-73: 2002

41. Tershakovec AM, Rader DJ. Disorders of lipoprotein metabolism and transport. In: Nelson Textbook of Pediatrics . 17th edition. Behrman RE, Kliegman RM, Jenson HB (eds), WB Saunders, Philadelphia, PA; 2002

42. Rader DJ, Hobbs HH. Disorders of lipoprotein metabolism. In: Harrison’s Textbook of Medicine, 16th Edition. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL (eds), McGraw-Hill; 2003

43. Rosas S, Szapary P, Rader DJ. Management of selected lipid abnormalities: hypertriglyceridemia, isolated low HDL-cholesterol, lipoprotein(a), and lipid abnormalities in renal diseases and following solid organ transplantation. Cardiol Clin 21:377-392: 2003

44. Rader DJ. Effects of nonstatin lipid drug therapy on high-density lipoprotein metabolism. Am J Cardiol 91:18E-23E; 2003

45. Dunbar RL, Rader DJ. Slaying the metabolic syndrome. Are we battling the Hydra or the Chimera? Minerva Endocrinol. 29(3):89-111; 2004

46. Dunbar RL, Rader DJ. Demystifying triglycerides: a practical approach for the clinician. Clev Clin J Med. 72(8):661-6, 670-2, 674-5; 2005


47. Dunbar RL, Rader DJ. Current drug options for raising HDL cholesterol. Curr Treat Options Cardiovasc Med 7:15-23; 2005

48. Broedl UC, Rader DJ. Gene therapy for lipoprotein disorders. Expert Opin Biol Ther 5:1029-38; 2005

49. Rader DJ, Hobbs HH. Disorders of lipoprotein metabolism. In: Harrison’s Textbook of Medicine, 17th Edition. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL (eds), McGraw-Hill; 2007

50. Rader DJ. Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med. 120(3 Suppl 1):S12-8; 2007

51. Rader DJ. Liver X receptor and farnesoid X receptor as therapeutic targets. Am J Cardiol. 100(11A):S15-9; 2007

52. Toh SA, Rader DJ. Dyslipidemia in insulin resistance: clinical challenges and adipocentric therapeutic frontiers. Expert Rev Cardiovasc Ther. 2008 6(7):1007-22; 2008

53. Bays HE, Rader DJ. Does nicotinic acid (niacin) lower blood pressure? Int J Clin Pract. 63(1):151-9; 2009

54. Shah A, Rader DJ, Millar JS. The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans. Atherosclerosis; 210(1):35-40; 2010

55. Khera AV, Rader DJ. Future therapeutic directions in reverse cholesterol transport. Curr Atheroscler Rep. 12(1):73-81; 2010

56. Gordon RY, Becker DJ, Rader DJ. Reduced efficacy of rosuvastatin by St. John's Wort. Am J Med. 122(2):e1-2; 2009

57. Brown WV, Brewer HB, Rader DJ, Schaefer EJ. HDL as a treatment target. J Clin Lipidol. 4(1):5-16; 2010

58. Nijjar PS, Burke FM, Bloesch A, Rader DJ. Role of dietary supplements in lowering low-density lipoprotein cholesterol: a review. J Clin Lipidol. 4(4):248-58; 2010

59. Strong A, Rader DJ. Clinical Implications of Lipid Genetics for Cardiovascular Disease. Curr Cardiovasc Risk Rep. 4(6):461-468; 2010

60. Lagor WR, Rader DJ. Phospholipidation of HDL--How Much Is Too Much? Clin Chem. 57(1):4-6; 2011

61. Rader DJ, Hobbs HH. Disorders of lipoprotein metabolism. In: Harrison’s Textbook of Medicine, 18th Edition. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J (eds), McGraw-Hill; 2011

62. Larach DB, Degoma EM, Rader DJ. Targeting high density lipoproteins in the prevention of cardiovascular disease? Curr Cardiol Rep. 2012 Dec;14(6):684-91. PMCID: PMC3517174

63. Keenan TE, Rader DJ. Genetics of lipid traits and relationship to coronary artery disease. Curr Cardiol Rep. 2013 Sep;15(9):396. PubMed PMID: 23881580

64. Strong A1, Patel K, Rader DJ. Sortilin and lipoprotein metabolism: making sense out of complexity. Curr Opin Lipidol. 2014 Oct;25(5):350-7. PMID: 25101658

65. Khetarpal SA, Rader DJ. Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease. Biochim Biophys Acta. 2014 Oct;1842(10):2010-2020. PMID: 24931102













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