2004 Hormones

HormonesU 1000 Cytochrome P450/NADPH-Dependent Formation of trans Epoxides from

trans-Arachidonic Acids. — Hepatic microsomes oxidize trans-arachidonic acids, products of cis-trans isomerization of arachidonic acid by nitrogen dioxide radical, via cytochrome P-450/NADPH system to epoxides, which are hydrolyzed by epoxide hy-drolase to diols. The reactions are carried out with radio- and deuterium-labeled sub-stances, the products are analyzed by HPLC with a radio detector or by GC-MS. — (ROY, U.; LOREAU, O.; BALAZY*, M.; Bioorg. Med. Chem. Lett. 14 (2004) 4, 1019-1022; Dep. Pharmacol., New York Med. Coll., Valhalla, NY 10595, USA; Eng.) — H. Haber

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