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PA R I S R E G I O N
B I O C L U S T E RTHE ALCHEMY OF SUCCESS
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Paris Region is at the forefront of the Life Sciencesin Europe
(Ernst & Young report, 2004), and whatbetter testimony than the
Paris Region BioCluster, aconvergence of leading pharmaceutical
companies,medical device manufacturers, biotech companies,services,
hospitals, research centers and academicinstitutions, all located
in the region. The willingnessof players in both the public and
private sectors to joinforces to energize and accelerate the
development ofBioCluster promises that the Paris Region region
canlook forward to a sustainable growth.
BioTeam Paris Region supports and coordinates theBioCluster
project, promoting international visibility ofBioCluster and
providing companies with resourcesand services to set up in the
Paris region.
> Paris Region BioCluster:gateway to innovation
Paris Region BioCluster counts some 830 pharma-ceutical
companies, medical device manufacturers andbiotech firms employing
more than 46,600 people.These enterprises are always on the lookout
for part-nerships and collaborations to promote discovery,
inno-vation, production and commercialization.
Pharmaceutical companies:Paris Region, No 1 in Europe
Over 320 companies with a workforce of 32,200.Nineteen of the
twenty worldwide leaders are locatedin Paris Region, including
GlaxoSmithKline, Novartis,
Pfizer, Sanofi-Aventis, to name a few. A good many ofthem have
entered into contractual collaborationswith biotech companies
(Lilly and Cerep, Sanofi-Aventis and Immuno-Designed Molecules are
someexamples).
Medical device manufacturers:
Paris Region, No 2 in Europe
360 companies employing more than 10,400 people. Worldleaders
like B Braun Medical, General Electrics MedicalSystems, Guerbet and
Siemens are present in the region.
Biotech companies:Paris Region, No 2 in Europe
150 companies, or about half of the nationwide total,employing
some 4,000 people. Amgen, Biogen Idec,Genzyme and Serono are just
some of the world lead-ers located in the region, alongside French
biotech com-panies like Bioalliance, BioMedical Diagnostic,
Cerep,Chemunex, Diatos, Exonhit Therapeutics,
Hybrigenics,Immuno-Designed Molecules, Nautilus and Urogene.
70% of venture capital investments in France are slatedfor
biotech companies in Paris Region, making for adynamic sector and
underscoring the confidence inthis melting pot of competencies. To
further promoteresearch and innovation, the Paris Region
Regional
Council has decided to double its R&D expenditures to5% of
its total budget. A large part will be used to accel-erate the
development of the Paris Region BioCluster.
> Paris Region Research:a tradition of excellencedating back
to Pasteur
Paris Region ranks as the No 1 science and technologyregion in
the 25-member European Union, accounting
for 7.5% of European domestic R&D expenditures andhosting
some 11,800 researchers, 4,400 of whom workin industry. The human
and financial resources it has tooffer outweigh those of other
countries such as theNetherlands or Spain.
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> Paris Regionkey figures
Population: 11 million5.4 millionjobsLeading industrial region
in Franceproviding 14.9% of industrial employmentnationwideGDP: 430
billion617,000 businesses17 universities20,000 engineers trained
every year68,000 researchers2,500 private and public
laboratories
> Paris RegionBioCluster
880 companies and 57,000 direct jobs(pharmaceutical groups,
medical devicemanufacturers, biotech companies,CROs, academic
research)11,800 researchersof which 7,400 in academic research600
health care establishments80,000 beds and 42,000 practitioners9
universities and more than 20 highereducation institutions in the
Life Sciences
> Number of companiesin the three main Europeanclusters for
the year 2004
Paris Region Greater London Bavaria
* Amadeus data for pharmacy and medical device,Paris Region
Development Agency, London First and Lifescience Bavaria
data for biotechnology
900
800
700
600
500
400
300
200
100
100
Pharmaceutical
companies
Medical device
manufacturers
Biotech
companies
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Paris Region places first among all European regions(Ernst &
Young report) in terms of the number of pub-lications in
fundamental biology, medical research,applied biology and ecology -
further proof of its inter-national reputation. Paris Region is
also the Europeanleader, ahead of London, in pharma/biotech
patentapplications.
Oncology, cardiology, gerontology, infectious
diseases,neurosciences, gene and cell therapy,
genomics/post-genomics are just some of the internationally
recog-nized competencies. Today, the Regional Council isbacking a
number of projects being developed in thesefields, such as
Canceropole Paris Region (oncology),the Brain and Spinal Cord
Institute and Neurospin (neu-rosciences and degenerative
diseases).
The Regional Council is also boosting funding for pres-tigious
centers of research such as the Pasteur Insti-tute (infectious,
parasitic and nosocomial diseases)and the Evry Genopole
(biotechnology).
Academic research collaborations with foreign insti-tutions are
numerous, and there is a strong participa-
tion in international networks such as The EuropeanVascular
Genomics Network, coordinated by the ParisRegion researcher Dr.
Alain Tedgui from INSERM, andCOBRA (to fight against bacterial
antibiotic resistance)directed by Prof. Laurent Gutmann from
INSERM.
Paris Paris Region derives its international renownfrom the
sheer numbers of Life Science institutionsincluding, among others,
CNRS, INSERM, InstitutPasteur, Institut Curie, Institut Gustave
Roussy, CEA,Evry Genopole, Hpital Saint-Louis,
HpitalPiti-Salptrire, Hpital Henri Mondor, Universit
Pierre et Marie Curie and Ecole Normale Suprieure.Prestigious
centers of research, these differentinstitutions also act as
business incubators. Indeed,from 1999 to 2003, the CNRS in Paris
Region aloneseeded 25 new companies.
Two ambitious projects illustrate the regions poten-tial for
technological innovation. The first is theSynchrotron Soleil, under
construction on the Saclayplateau, which will serve as a center of
cutting-edgescientific research. When it opens in 2006, its
300researchers and technicians will use their know-how inphysics,
materials sciences, biology and medicine,chemistry, environmental
sciences and geophysics topush back the boundaries of their
fields.
ImaGene, a multidisciplinary imaging platform for thedevelopment
and validation of preclinical and clinicalcell and gene therapy
approaches, is the fruit of a jointcollaboration between INSERM and
the CEA. It will belocated at the CEA facilities in
Fontenay-aux-Roses.
The private research sector in Paris Region can only bedescribed
as dynamic and entrepreneurial. Paris Regionplays host to the world
leaders in pharmaceuticals(Sanofi-Aventis, GlaxoSmithkline),
medical device man-ufacturers (General Electrics Medical Systems)
andbiotechnology companies (Immuno-Designed Molecules,Serono). Its
enormous workforce and high level of R&Dbudgeting for private
research make Paris Region a driv-
ing force for innovation in the Life Sciences.Partnerships
between private industry and publicresearch are on the rise. A
prime example is Taxotere,an anticancer blockbuster at
Sanofi-Aventis that wasdiscovered by a CNRS group in Paris
Region.
As far as clinical research is concerned, Paris Regionboasts
more than 600 health care establishments with80,000 beds, 42,000
practitioners and a recruitmentpotential of 11.5 million
inhabitants. AP-HP (AssitancePublique-Hpitaux de Paris) is the
largest hospital net-work in Europe with 45 hospital centers and
25,000
beds, and the leader in clinical trial research in France.CROs
(Contract Research Organizations), which man-age clinical trials,
have a considerable presence inParis Region, and the 10 world
leaders including MDSPharma Services, PPD, and Quintiles are
located here.
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> Educational institutions:generating a steadystream of
highly qualifiedprofessionals
Nine universities in the region offer a completeMedical and Life
Sciences curriculum, with acombined student body of 45,000 in the
Life Sciences,34,000 in Medicine (in collaboration with 12
teachinghospitals), 5,400 in Pharmacy and 2,450 in
Dentistry.Specialized masters degrees provide
additionalqualifications in fields such as
bioinformatics,biostatistics, law, health economics and many
more,thanks to partnerships between universities andresearch
institutions (among others: AP-HP, CEA,CNRS, INSERM)
Graduate schools grant more than 460 Ph.D.s everyyear in a
variety of fields including biochemistry,molecular biology,
oncology, and biomaterials.
Some 20 higher education institutions offer advancedtraining
geared to different sectors, from engineers:Institut Suprieur des
Biosciences, Institut SuprieurBiotech de Paris, Ecole de Biologie
Industrielle, EcolePolytechnique, Ecole Suprieure de Physique et
deChimie Industrielles, to managers: ESA BIO, Institut
Suprieur de Technologie et Management, to name afew.
Thanks to the quality and complementarity of educa-tional
institutions in Paris Region, companies can tapinto a huge
reservoir of highly qualified professionalsto meet their needs.
Upper level executive and profes-sional positions account for
one-fourth of the workingpopulation. The appeal of the Paris region
is also anundeniable asset that helps companies attract top-flight
professionals from all over the world.
> Paris Region BioCluster:a business catalyst
Paris Region also plays host to the partners of Bio-Cluster
businesses, including manufacturers (Delpharm,LCO Sant),
pharmaceuticals distributors (CERPRouen, OCP Rpartition), medical
visitor services(Cider Sant), and strategy, marketing,
regulatoryaffairs and industrial property consultants, togetherwith
two regional centers for innovation and technologytransfer (CRITT
Chimie and Bio CRITT). Last but notleast, the fact that all the
governmental authorities(ministries, AFSSAPS, GEMED) are present in
theregion is an advantage that cannot be overlooked.
Access to financing and to specialized real estate
isparticularly easy in Paris Region. The region counts90% of all
venture capital firms specialized in the LifeSciences present in
France, in addition to regional seed-stage (CapDcisif) and venture
capital funds (ParisRegion Dveloppement).
As the European leader in business real estate, ParisRegion can
offer facilities specially dedicated to the LifeSciences. With 10
specialized sites, in 2005 the compa-nies in BioCluster can choose
from more than 110,000square meters of industrial/office space, at
highly com-petitive prices ( 200-500 per sq. m. before charges).
In
addition historic industrial sites can be found within a20 km
radius of Paris. An additional 34,000 sq. m. ofspace will become
available between 2005 and 2006.
With two international airports and a high-speed trainsystem
(TGV), Paris is less than an hour and a half fromLondon, Frankfurt
or Brussels. Easy access also makesParis Region a top choice for
meetings and conven-tions such as Eurobiotech, Mdec, Pharmagora,
whichbring together European-wide decision-makers inindustry,
research and financing.
After al l is said and done, Paris Region BioCluster conjures up
a
winning mix of indus t ry , b io tech , academic research ,
hospi t a l s ,
bus i ness env ironm en t an d in f ra s t ru ct u r es . And on
t op o f a ll tha t ,
t h e p r e fe r r e d m e et in g v en u e of E u r o p ea n in
v es t o r s o f fe r s a nu n equ alled qu al ity of l ife r ecogn
ized th e world over.
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Paris I le-de-FranceAgence Rgionale de Dveloppement
3, rue des Saussaies, 75008 Paris, FranceTl: 33 (1) 58 18 69
00
www.paris-region.comwww.bioteam-parisregion.orgcontactbioteam@paris-region.com
> Bioteam Paris Region
An umbrella organization created at the initiativeof Paris
Region Development Agency,Essonne Development and Paris
Development,Bioteam Paris Region brings together andcreates
synergies between the key playersin the Life Sciences sector in
Paris Region:local governments, business, academic
research,hospitals as well as a vast network of competenciesand
resources including business incubators, CROs,intellectual property
expertise, consultingand supporting services.
Bioteam Paris Region also countsthe Essonne Chamber of Commerce
and Industryand the Val-de-Marne Development Agencyamong its
partners.
Bioteam Paris Region implements and coordinatespromotional
activities to give Paris Region BioClusterinternational visibility
and recognition.
> PDRA
Paris Region Development Agency (PRDA)has four main
missions:
Prospecting
bio entrepreneurs, particularly world wide companies, that want
to set up in Paris Region,welcoming and helping them find all the
resourcesthey need to consolidate their presence in the region.
Promotingthe regions international image as an economicand
technological hub.
Sharingstrategic economic information with playersinvolved in
developing the local economy.
Participatingin the redevelopment of transitional areasand
sites.
