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Explain how a peptide bond is formed. (What is the reaction called and how does it happen?)
TAKE OUT YOUR AMINO ACID CHART
Protein Structure• The structure of a
protein is very complex, with many twists and folds.
• Proteins are folded into a 3-dimensional structure and held together by chemical bonds.
4 Levels of Protein Structure
PrimarySecondaryTertiaryQuaternary
Primary Structure(1st Level)
The linkage of amino acids in a specific order.
This connection is made by dehydration condensation and called a peptide bond.
Primary Structure(1st Level)
The linkage of amino acids in a specific order.
This connection is made by dehydration condensation and called a peptide bond.
Disulfide Bridges Some primary structures include disulfide bridges
These are formed when 2 cysteine amino acid molecules lost their H (hydrogen) and covalently bond together
DiSulfide Bridge (Primary structure)
Secondary Structure(2nd Level)
The polypeptide chain (chain of a.a.) will begin to form H-bonds with adjacent a.a. molecules
H-bonds are somewhat weak so they will form, break, and reform as the protein continues to twist and take a shape.
Secondary Structure(2nd Level)
Many H-bonds are needed to hold together a secondary structure (the more, the stronger the hold)
There are 2 kinds of secondary folding patterns:
1. Alpha Helix2. Beta pleated
sheets
Secondary Structure(2nd Level)
Many H-bonds are needed to hold together a secondary structure (the more, the stronger the hold)
There are 2 kinds of secondary folding patterns:
1. Alpha Helix2. Beta
pleated sheets
Alpha HelixThe slightly negative Oxygen from the carboxyl (COO-) forms a H-bond with the slightly positive Hydrogen from the amino group (NH3+)
Beta Pleated SheetThe slightly negative Oxygen from the carboxyl (COO-) forms a H-bond with the slightly positive Hydrogen from the amino group (NH3+)
Video on Protein Folding
http://youtu.be/lijQ3a8yUYQ
http://youtu.be/yZ2aY5lxEGE