David BannAssociate Professor in Population healthCo-Investigator of the birth 1958 cohort

Thanks to our funders and host institution

Run four major national longitudinal studies- Follow thousands of people across life- Collect extensive & rich data

Provide free data to research community (via UK Data Archive)- Documentation, guidance & training- Researchers can input on the data we collect (consultations)

Conduct research- Multidisciplinary, substantive & methodological (survey and statistical)

What we do at CLS (ESRC funded)

1920 1940 1960 1980 2000 2020

Follow-up across life, N>16,000

cls.ucl.ac.uk

Study timelines and future 2020-2030

1950196019701980199020002010202020302040

0 10 20 30 40 50 60 70

Year

Age

Next Steps NCDSMCS BCS70

Mental + physical health outcomes

Social and biological exposures

Note ongoing harmonisation programmes (CLOSER): SEP, physical activity, diet, cognition, overcrowding, psych etc

Time trends in adolescent mental healthStephan Collishaw,1 Barbara Maughan,1 Robert Goodman,2 and Andrew Pickles3

Childhood Risk Factors for Lifetime Anorexia Nervosaby Age 30 Years in a National Birth CohortDASHA E. NICHOLLS, M.B.B.S., M.D., AND RUSSELL M. VINER, M.B.B.S., PH.D.

Factors associated with childhood cancer in a national cohort studyJ. Golding', M. Paterson' & L.J. Kinlen2 Breastfeeding and Hospitalization for Diarrheal and

Respiratory Infection in the United KingdomMillennium Cohort StudyMaria A. Quigley, MSca, Yvonne J. Kelly, PhDb, Amanda Sacker, PhDb

How active are our children? Findings from the Millennium Cohort StudyLucy J Griffiths,1 Mario Cortina-Borja,1 Francesco Sera,1 Theodora Pouliou,1 Marco Geraci,1 Carly Rich,1 Tim J Cole,1 Catherine Law,1 Heather Joshi,2 Andrew R Ness,3 Susan A Jebb,4 Carol Dezateux1

At a glance: core data collections 2015-2020+

2015 2016 2017 2018 2019 2020 2021

July 2019

Early 2020

Ongoing

New development

Saliva samples collected from cohort members + resident biological parents Oragene DNA kit - assayed using Illumina Infinium Global Screening Array

N saliva samples:

Cohort member 9360Main parent 9195Second parent 4936

TOTAL 23,491 Genotyping underway (Bristol); access via special Access Committee (end 2019)

Other forthcoming data: MCS7, Age 17 survey - Data deposit at UKDS ~ early 2020

MCS update: genetic data (from age 14 saliva samples)

Adult biomedical data collections

Cohort: Age Data available

NCDS 1958 44/45y Currently

61/62y ~2021-22

BCS 1970 46y 2019 (imminently)

1958 cohort: measures collected at age 61/2y (fieldwork 2019-)

• -> within (44/45y) & cross-cohort comparability, new research areas:

• Self-report:• Health conditions, physical & mental health, mental wellbeing, health behaviours• Online diet questionnaire• 1/3 life history questionnaire

• Measured: • Cognition (memory, verbal fluency, attention/mental speed)• Anthropometrics, body fat %• Physical function (grip, balance, walking speed) • Blood pressure (resting, standing)• Blood (lipids, glucose, stored samples for ‘omics, epigenetics etc)

1970 1975 1980 1986 1996 2000 2004 2008 2012 2018Birth 5 10 16 26 29/30 34 38 42 46

Parent Parent

School

Parent

School

Parent

School

Cohort member

Cohort member

Cohort member

Cohort member

Children(1 in 2)

Cohort member

Cohort member

Cohort member

MedicalTests

MedicalTests

MedicalTests

MedicalTests Tests

Medical

Sources of information – BCS70R

espo

nden

tsIn

stru

men

ts

Cohort profile

5 10 16 26 30 34 42

Telephone16571

13071

14874

11621

9003

11261

96658874

9841

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44

38Birth

Postal TelephoneMissing data:• Reduces power and

potentially introduces bias

• Increasingly researchers can address this using data which predicts missingness (eg, early life socioeconomic circumstances)

• eg, multiple imputation, FIML, inverse probability weighting

Participation/response in BCS70 across life

Age 46 Survey Content (N=8,581)

• Questionnaire:• Household composition, relationships: • Finances and employment: • Health, well-being and cognition:

• Physical & mental health, mental wellbeing, medical care, medication, smoking, drinking, diet, exercise, cognitive function (as per NCDS Age 50)

• Word list recall – immediate and delayed memory; Animal naming – executive function; Letter cancellation – concentration / attention to detail

• Nurse measures:• Anthropometry, physical function (grip, balance), blood pressure (sitting), blood sample,

accelerometry (ActivPal for 7 days)

• Online diet questionnaire (Oxford WebQ: 2x24 hour recall)

Link to questionnairesMain data available July 2019; Dec 2019 for accelerometery

https://cls.ucl.ac.uk/events/introduction-to-the-1970-british-cohort-study-age-46-sweep/

Free webinar tomorrow

ukdataservice.ac.uk

CLS and other data freely available to researchers, government analysts and third sector

Find out more aboutthe cohort studies at cls.ucl.ac.uk Each study page features information on:

- Study sweeps- Sub-studies- Latest news- Recent publications- Study features- Popular documentation- Data access- Principal Investigator

Thank you!Any Questions?

BCS70: Next up – Age 50 Survey (2020-21)

• Face to face interview – 75 minutes• Cross-cohort comparability with NCDS Age

50 Survey• Piloting and development – 2019• Main stage of data collection – 2020-21

BCS70: Next up – Age 50 Survey (2020-21)• Household composition• Partners/ Children / Grandchildren• Social contact• Housing• Employment/Income (including retirement expectations)• Health (physical and mental health/well-being)

• Smoking (including e-cigarettes) and Drinking• Exercise / Physical activity /Leisure activity• Sleep• Diet

• Cognition (including cultural knowledge)• Social participation (attitudes, voting, technology, religion, domestic life)• Workplace bullying, intimate partner violence

CLS record linkage programme – existing/planned consentsDomain Country Study Data set / information Access

(current status)

Education

England MCS

Next Steps

• National Pupil Database (NPD) KS1,KS2• National Pupil Database (NPD) (KS1-KS4 including GCSE

results, pupil level school census data and absence data)• NPD- Up to KS4• Individualised Learner records (ILR)• NPD (KS4-KS5, School Census)

Currently availableAvailable- June 2019

Currently availableSummer 2019Summer 2019

Scotland MCS • NPD KS1 Currently available

Wales MCS • Welsh National Pupil Database (KS1)• Welsh National Pupil Database (up to KS4)

Currently availableSummer 2019

Health England All studies • Hospital Episodes Statistics (HES) plus primary care data Summer 2019/Summer 2020 (MCS)

Scotland All studies • Inpatient, Outpatient, Maternity inpatient/day cases Autumn 2019

Wales MCS • Up to age 11- Health, Emergency Hospital inpatient (PEDW), Primary Care General Practice, Welsh Demographic Service.

• Up to age 14

Currently available

Summer 2019

Economic England All studies • Benefit claims and employment programme• Tax credits, NI contributions, income

Currently unknownSpring 2020

Crime England MCS, Next Steps

• Police National Computer (PNC) Spring 2020

Saliva samples collected from cohort members + resident biological parents Oragene DNA kit - assayed using Illumina Infinium Global Screening Array

N saliva samples:

Cohort member 9360Main parent 9195Second parent 4936

TOTAL 23,491

Genotyping underway (Bristol); access via special Access Committee (end 2019)

Measures: genetics (from age 14 saliva samples)

1958 cohort: measures obtained at 44/45y

Early & late morning saliva cortisol

Glycosylated haemoglobin fibrinogen Tissue plasminogen activator Von Willebrand factor C-reactive protein Triglycerides Total and HDL cholesterol Total and allergen-specific immunoglobulin E Insulin-like growth factor 1 Vitamin DDNALymphoblastoid cell lines

Genetic data

Epigenetic data (N=240+300 underway)

1. Create an account

2. State the purpose of the project

3. Find datasets of interest

4. Agree to data security and other policies

5. Download the data and related supporting documents!

(in SPSS or STATA)

Access from…UKDA (UK Data Archive)

metadac.ac.uk/1958bc-resource-types/

Access to genetic data and biological samples in NCDS via META-DAC

Data Linkage – Health

Linkage of Health Administrative Records

Cohort Type of data StatusNCDS (1958) Cohort death

Hospital Episode StatisticsAvailable : Special LicenceIn progress (England and Scotland)

BCS (1970) Hospital Episode Statistics In progress (England and Scotland)

MCS (2000/1) Hospital data

Cohort members’ health records

Available:Maternity and birth registration records: standardHospital of birth: Special Licence

Consent at age 17

Next Steps(1989/90)

Hospital Episodes Statistics Consent gained at age 25

Next Steps Health Measures – Age 25 (self-assessed)(Newly available since end of June)

• General health • Height and weight (derived BMI) • Long standing mental or physical health condition and whether it effects

• Vision; hearing; mobility; dexterity; learning or concentrating; memory; mental health; stamina or breathing or fatigue; socially or behaviourally

• Ability to work is limited for a health or disability reasons • GHQ-12 Screening tool for symptoms of mental ill health• Number of hospital admissions/ day surgery in the past 12 months • Lifestyle:

• Frequency of exercising over 30 minutes per week• How many hours sleep they get each night (on average)• Frequency of eating takeaways and drinking fizzy drinks

MCS an example of health content

2000/01 2001/2 2003/4 2005/6 2008/9 2012/13 2015/16Birth 9

months3 5 7 11 14

Overview of health and biomedical datacollection: cohort member

Parent-reported ↓

AGE

9 mths

3 5 7 11 14

Birth weight and gestational age

Developmental milestones

Immunizations

Incidence/number of health problems (e.g. chest, ear infections, skin problems)

Accidents and injuries

Hospital visits/admissions

Long-standing health condition

Pubertal development

Mental health

Overview of health and biomedical datacollection: cohort member (contd.)

AGE

9 mths 3* 5* 7 11 14

Objective measures ↓

Height and weight

Waist measurement

Body fat percentage

Cognitive assessments

Physical activity (accelerometers)

CM self-response ↓

Pubertal development

Well-being and happiness

Smoking and alcohol consumption

Overview of health and biomedical datacollection: parents

Self-reported ↓ AGE

9 mths 3 5 7 11 14

Fertility treatment, antenatal care, health problems during pregnancy

Mode of delivery, pain relief, complications

Breastfeeding

Mother’s smoking/alcohol consumption before/during/after pregnancy

Parental health

Parental longstanding illness and disability

Parental mental health

Parental height/weight

Parental smoking/alcohol consumption

Saliva (DNA) and teeth

AGE

9 mths 3 5 7 11 14

Oral fluid (CM)

Shed milk teeth (CM)

Saliva sample (CM + natural parents)

Saliva sample• First time a triad of DNA samples collected from 2 biological parents and child in a large scale study• Samples collected using Oragene DNA kit • Number of saliva samples: 9364 (CM) 9197 (MP) 4938 (2nd P) TOTAL 23,499• University of Bristol is collaborating with MCS team in storing the samples and extracting the DNA• DNA extractions will be genotyped in order to allow for analysis of different genes and their

relationship with areas such as health and wellbeing, growth and behaviour• Plans for genotyping underway; process likely to take 1-2 years; access in due course will be via a

special Access Committee