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Deadline = line + dead. think about it. deadline |ˈdedˌlīn| noun 1 this definition not relevant 2 historical a line drawn around a prison beyond which prisoners were liable to be shot. - PowerPoint PPT Presentation
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1Deadline = line + dead
deadline |ˈdedˌlīn|noun1 this definition not relevant2 historical a line drawn around a prison beyond which prisoners were liable to be shot.
think about it
Does it really make sense to designate that period at the end as the target as opposed to that at the
beginning?
Is it really the case that your schedule is such that all available times just happen to fall at the last minute?
22
Beating TamifluBeating TamifluThemes:
Evolution: then and nowamino acids, mutations, folding: they
matter
Themes: Evolution: then and now
amino acids, mutations, folding: they matter
3How evolution happens
• Good ideas are rewarded not sought/planned
• There’s no mechanism for foresight, so it cannot be that way
4Just passin’ through
http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif
5Tamiflu: you shall not pass!
http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png
a.k.a. oseltamivir
6And it goes like this...
http://www.ks.uiuc.edu/Research/influenza/
Note: this is modeled, not a crystal structure
7Cell sorting
• Laser is like a black light--molecules GLOW a different color than they are being hit with
• In our case, GFP (green) and cherry (you guess it)
8Phylogenetic trees
• Participants: to your spot on the tape!
• Observers: watch & predict outcome and what it’s good for
Each round:Copy any changes your parent already hasDetermine position of your new change by adding #s (0 = none)Randomly change to new base & mark (A, G, C, U)Turn to your kids & repeat
9Supplemental note
• What we did was just the tip of the iceberg
• among other things, the same basic thinking can be done to reconstruct a tree even if we only have the current [last] generation
• try putting your thumb over any individual and seeing if you can guess their sequence by looking at their children
1010
SupplementalSupplementalStuff you might find usefulStuff you might find useful
11Supplemental
• Cartoon of infections & tamiflu action (contr. Katie F12)
• http://www.youtube.com/watch?v=0qCTyKrhVWc
1212
UnusedUnusedThis was a graphical presentation of
what we ended up doing ‘live’ in class. It tries to make the same points: the
‘correct’ reconstruction has fewer total changes (parent-child sequence alterations) than a random one
This was a graphical presentation of what we ended up doing ‘live’ in class. It
tries to make the same points: the ‘correct’ reconstruction has fewer total
changes (parent-child sequence alterations) than a random one
13
14Now what???
What information allows you to make good inferences about who is most related?
Who gave rise to whom?
15
Which makes sense?
Or this?Or this?Or this?Or this?
16How about this?