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DEB3 Bas Kooijman Dept Theoretical Biology Vrije Universiteit, Amsterdam http://www.bio.vu.nl/thb/. Nantes 28 Oct 2008. DEB3 statistics. Energy & metab. Multivariate DEB. Effects of comp. Univariate DEB. Basic concepts. Living together. Standard DEB. Co-variation. Extensions. - PowerPoint PPT Presentation
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DEB3Bas Kooijman
Dept Theoretical BiologyVrije Universiteit, Amsterdam
http://www.bio.vu.nl/thb/
Nantes28 Oct 2008
DEB3 statistics
01 02 03 04 05 06 07 08 09 10 11 tot chapters
22 54 34 68 30 42 28 48 46 44 8 423 Pages (xvi+492)
3 59 43 29 32 55 85 9 50 0 0 365 Numbered equations
3 5 4 3 2 0 0 3 6 0 2 28 Numbered tables
8 19 11 30 12 16 25 15 17 11 2 163 Numbered figures
4 11 2 23 5 12 8 10 7 0 0 82 Fits
0 1 0 3 1 2 9 2 8 2 1 29 Simulations
0 1 0 0 0 2 0 0 1 0 0 4 Data
Bas
ic c
once
pts
Sta
ndar
d D
EB
Ene
rgy
& m
etab
.
Uni
varia
te D
EB
Mul
tivar
iate
DE
B
Effe
cts
of c
omp.
Ext
ensi
ons
Co-
varia
tion
Livi
ng to
geth
er
Evo
lutio
n
Eva
luat
ion
Sho
rt tit
le
30 new features in DEB3• Improved text organisation/presentation• New set of primary parameters• Maturity as fundamental state variable• Emphasis on homeostasis, incl evolution• Mechanism reserve dynamics/merging• New chapter on evolution• Parameter estimation in steps• Isotope dynamics• Thermodynamic aspects extended• Aging extended (includes demand syst.)• New patterns in par-values/QSARs,temp• SU theory extended: shrinking, adaptation, social interaction, co-metab• Static/dynamic generalisation κ-rule• Trajectory reconstruction (reprod/otolith)• Separation of cells in early embryos
• Handshaking in chains of SUs• Organnelle-cytosol interactions• Metamorphosis • Reproduction-buffer handling rules• Isomorphs as V0-morphs• Flocculated growth• Otolith growth• Pseudo-faeces production• Photo-inhibition• Mother-foetus interactions• Changes in composition during starving• Extra-cellular digestion• Hormesis• Film models• Effects of mixtures extended (NECs)
Hazard rate Survival Prob
Aging in DEB3
Aging in DEB3
Aging: non-growing ectotherms
time, d
surv
ival
pro
b
Data: Rose 1984Weibullwith shape parameter 3
Aging: growing ectotherms
time, dtime, d
surv
ival
pro
b
body
wei
ght,
g
Data: Slob & Janse 1988
Weibull with shape 3 fits ectothermic survival well, even if growth period not small relative to life span
Aging: relation to O2-use
time, dtime, d
surv
ival
pro
b
Reo
druc
tion
rate
, #/d
Data: Ernsting & Isaaks 1997
0.374
0.547
0.630
high food 10/20°Chigh food 10/10°Clow food 10/20°C
Differences in life span are caused by differences in respiration
Aging: sex differentiation
time, dtime, d
surv
ival
pro
b
body
wei
ght,
g
Data: MacArthur & Baillie 1929
Differences in aging between sexes are caused by differences in g
Aging: endotherms & feeding
time, dtime, d
time, d
surv
ival
pro
bem
bryo
wei
ght,
g
body
wei
ght,
g
Data: Weindruch et al 1986 MacDowell et al 1927
feedinglevel
1
0.75
0.44
0.75
0.44
1
Life span • hardly depends on food in ecotherms• decreases for increasing food in endotherms
Aging among species
Conclusion for life span • hardly depends on max body size of ectotherms• increases with length in endotherms
slope 1/3, 1/5
Right whale
Ricklefs & Finch 1995
Phil Transactions Royal Soc
I Biology/chemistry-implicit theory: concepts & fundamentals
2 Jean-Christophe Poggiale & Melika Baklouti & Valerie Lemesle: primary production, time scale separation in microalgae
dynamics3 Goncalo Marques & Antinio Lorena & Tania Sousa & Bas
Kooijman: The interaction between light, nutrients and temperature on microalgae4 Odo Diekmann & Hans Metz: How to lift a model for individual behaviour to the population level ?5 Olivier Maury & JC Poggiale: body size spectra (but now with DEB)6 Susana Vinga: DEB applications at the molecular scale7 Ingeborg van Leeuwen & Olaf Wolkenhauer & Julio Vera: Molecular and organismal aspects of aging in DEB context8 Michael Kearney & Steve Simpson & David Raubenheimer & Brian Helmuth Toward a functional trait perspective on the ecological niche9 Laure Pecquerie & Roger Nisbet & Bas Kooijman Dynamics of isotopes
II Biology/chemistry-explicit theory: applications
10 Henk van der Veer & Marianne Aluno-Bruscia: evaluation of the JSR special double issue11 Tjalling Jager & Chris Klok: perturbations of DEB systems by toxicants, from individuals to populations12 Virginie Ducrot & Alexandre Pery: effects of toxicants on DEBs on individuals13 Frederic Alonzo & Sandrine Massarin: ecotoxicological applications on Daphnia14 Roger Nisbet: properties of daphnid populations, as derived from that of individuals15 Tineke Troost & Jeroen wijsman & Sofia Saraiva & Vania Freitas: cockle population dynamics16 Bob Kooi & Jaap van der Meer: the use bifurcation theory in adaptive dynamics, as illustrated with DEB-structure populations of Macoma
title: Developments in Dynamic Energy Budget theory and its applications1 Tiago Domingos & Tania sousa & JC Poggiale & Bas Kooijman Formalised DEB theory restores coherence in core biology
DEB tele course 2009 + symposium
http://www.bio.vu.nl/thb/deb/Free of financial costs for the course-partSome 250 h effort investment
Feb 12 – Mar 19: fundamental partApril 18 -- 22: symposium in BrestSept 10 – Oct 15: specialised part
Target audience: PhD studentsWe encourage participation in groups that organize local meetings weekly Software package DEBtool for Octave/ Matlab freely downloadable
Slides of this presentation are downloadable from http://www.bio.vu.nl/thb/users/bas/lectures/
Audience: thank you for your attention