DELIRIUM SCREENING CHECKLIST (ICDSC) RESYANA …

vi

DAFTAR ISI

HALAMAN JUDUL ..............................................................................................i

LEMBAR PENGESAHAN .................................................................................. ii

PERNYATAAN .................................................................................................... iii

KATA PENGANTAR .......................................................................................... iv

DAFTAR ISI ......................................................................................................... vi

DAFTAR TABEL............................................................................................... viii

DAFTAR GAMBAR ............................................................................................ ix

DAFTAR LAMPIRAN ......................................................................................... x

DAFTAR SINGKATAN ...................................................................................... xi

INTISARI............................................................................................................. xii

ABSTRACT ......................................................................................................... xiii

BAB I PENDAHULUAN ...................................................................................... 1

1. Latar belakang ..................................................................................................... 1

2. Rumusan Masalah ................................................................................................ 7

3. Pertanyaan penelitian .......................................................................................... 7

4. Tujuan Penelitian ................................................................................................. 8

5. Manfaat penelitian ............................................................................................... 8

6. Keaslian Penelitian ............................................................................................... 9

BAB II TINJAUAN PUSTAKA ......................................................................... 10

1. Delirium .............................................................................................................. 10

2. Faktor-faktor risiko ........................................................................................... 13

3. Diagnosis ............................................................................................................. 16

4. Patofisiologi......................................................................................................... 21

5. Pencegahan ......................................................................................................... 27

6. Terapi dan Prognosis ......................................................................................... 28

Kematian ................................................................................................................. 29

Morbiditas .............................................................................................................. 30

Lama tinggal ........................................................................................................... 30

Biaya ........................................................................................................................ 31

7. Kerangka Teori .................................................................................................. 32

8. Kerangka Konsep ............................................................................................... 33

DELIRIUM DI INTENSIVE CARE UNIT (ICU) RSUP DR SARDJITO DENGAN INTENSIVE CAREDELIRIUM SCREENINGCHECKLIST (ICDSC)RESYANA WIDYAYANI, Dr.Med.dr.Untung Widodo, Sp.An., KIC. ; dr. Akhmad Yun Jufan, Sp.An., M.Sc., KIC.,Universitas Gadjah Mada, 2021 | Diunduh dari http://etd.repository.ugm.ac.id/

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BAB III METODE PENELITIAN .................................................................... 34

1. Rancangan Penelitian ........................................................................................ 34

2. Tempat dan waktu penelitian ............................................................................ 34

3. Subjek Penelitianf .............................................................................................. 34

3.1 Populasi Penelitian ........................................................................................... 34

3.2 Sampel ............................................................................................................... 35

4 Estimasi Besar Sampel ....................................................................................... 36

5 Cara pengambilan sampel penelitian ................................................................ 36

6 Variabel penelitian dan pengukuran outcome.................................................. 38

6.1 Variabel bebas .................................................................................................. 38

6.2 Variabel tergantung ................................................................................... 39

6.3 Variabel perancu ........................................................................................ 42

8. Cara kerja ........................................................................................................... 44

9. Definisi operasional ............................................................................................ 46

10. Etika penelitian ............................................................................................... 54

BAB IV HASIL DAN PENELITIAN ................................................................ 55

4.1. Hasil Penelitian .................................................................................................... 55

4.2. Pembahasan ......................................................................................................... 70

BAB V KESIMPULAN DAN SARAN .............................................................. 83

5.1. Kesimpulan .......................................................................................................... 83

5.2 Saran ..................................................................................................................... 83

DAFTAR PUSTAKA .......................................................................................... 84


viii

DAFTAR TABEL

Tabel 1. Penelitian serupa yang pernah dilakukan .................................................. 9

Tabel 2. Status nutrisi berdasarkan WHO (WHO, 2019)...................................... 49

Tabel 3. Karakteristik Subjek Penelitian ............................................................... 56

Tabel 4. Karakteristik Luaran Subjek Penelitian .................................................. 58

Tabel 5. Hasil Observasi Delirium dengan skor ICDSC di ICU RSUP Dr Sardjito

............................................................................................................................... 59

Tabel 6. Skor RASS pasien di ICU RSUP Dr Sardjito ......................................... 61

Tabel 7. Skor ICDSC pasien di ICU RSUP Dr Sardjito ....................................... 62

Tabel 8. Karakteristik Umum dari masing-masing kelompok subjek penelitian .. 63

Tabel 9. Analisis Bivariat dari faktor-faktor risiko dikaitkan dengan delirium

subsindromal (skor ICDSC = 1-3) dan tidak delirium (skor ICDSC =0) ............. 66

Tabel 10. Hasil analisis multivariat faktor-faktor risiko delirium subsindromal

(skor ICDSC = 1-3) di ICU RSUP Dr. Sardjito .................................................... 69


ix

DAFTAR GAMBAR

Gambar 1. Domain faktor-faktor risiko ................................................................ 15

Gambar 2. Kerangka Teori .................................................................................... 32

Gambar 3. Kerangka Konsep ................................................................................ 33

Gambar 4. Hasil Perhitungan Sampel ................................................................... 38

Gambar 5. Bagan Prosedur Penelitian .................................................................. 43


x

DAFTAR LAMPIRAN

Lampiran 1 Lembar Penjelasan Kepada Pasien ................................................... 88

Lampiran 2 Persetujuan Keikutsertaan dalam Penelitian ..................................... 93

Lampiran 3 Formulir Pengumpulan Data Penelitian ............................................ 94

Lampiran 4 Skor RASS ........................................................................................ 98

Lampiran 5 ICDSC ............................................................................................... 99

Lampiran 6. Form Pencatatan Harian Penilaian Delirium. (*dapat diperbanyak

sesuai durasi perawatan pasien) .......................................................................... 101

Lampiran 7. Surat Izin Etik dari FKKMK-UGM............................................... 102

Lampiran 8. Surat Izin Etik dari RSUP Dr. Sardjito .......................................... 103


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DAFTAR SINGKATAN

ICU : Intensive Care Unit

RSUP : Rumah Sakit Umum Pusat

Dr. : Dokter

APACHE : Acute Physiology and Chronic Health Evaluation

LOS : length of stay

GCS : Glasgow Coma Scale (Score)

CAM-ICU : Confusion Assessment Method-Intensive Care Unit

DRS-R-98 : Delirium Rating Scale-revised-98

RASS : Richmond agitation-sedation scale

LAT1 : Large type aminoacid transporter-1

EEG : electroencephalogram

ICDSC : Intensive Care Delirium Screening Checklist

DSM-IV : Diagnostic and Statistical Manual of Mental Disorders

MDAS : Memorial Delirium Assesment Scale

ASA : American Society of Anesthesiologist

NuDESC : Nurse Delirium Screening Scale

DDS : Delirium Detection Scale

ATP : Adenosine Tri-Phosphate


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DELIRIUM SCREENING CHECKLIST (ICDSC) RESYANA …