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M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 1 of 29 SCAA Dt. 06.02.2014
BHARATHIAR UNIVERSITY, COIMBATORE – 46
M. Sc. Medical Physics (Univ. Dept.)
For the students admitted during the academic year 2014 – 2015 onwards
Scheme of Examination
Study
Components
Course Title Exam
CIA
@
Unit.
exam
Total
Sem
este
r I
Paper 1 Introduction to Atomic and Nuclear Physics 25 75 100
Paper 2 Radiation Physics 25 75 100
Paper 3 Electronics 25 75 100
Paper 4 Solid State physics 25 75 100
Paper 5 Applied Anatomy and Physiology 25 75 100
Practical Electronics Lab 25 75 100
Sem
este
r II
Paper 6 Statistical and Numerical Methods 25 75 100
Paper 7 Radiation Detectors and Instrumentation 25 75 100
Paper 8 Medical Imaging Technology 25 75 100
Paper 9 External beam Radiation Therapy 25 75 100
Paper 10 Radiation Dosimetry and Standardization 25 75 100
Practical Medical Physics Lab I 50 100 150
Summer training
Sem
este
r II
I
Paper 11 Brachytherapy and Computers in Treatment
Planning
25 75 100
Paper 12 Radiation Biology 25 75 100
Paper 13 Nuclear Medicine and Internal dosimetry 25 75 100
Paper 14 Radiation Hazards Evaluation and Control 75 75 150
Paper 15 Recent advances in Radiotherapy 25 75 100
Sem
IV
Practical Medical Physics Lab II 50 100 150
Project Project Work (45- 60 days) and Viva Voce 300 - 300
Total 2250
CIA split-up:
For all theory papers except RHEC : 10 (class test) + 5 (viva) + 5 (Sem.) + 5 (Assign.)
For RHEC : 20 (class test)+ 15 (int. 1 viva)+ 15 (int. 2 viva)+ 10 (Sem.)+ 5 (Assign.)
For practicals : 25 (int. 1) + 25 (int. 2)
For project:
100 (project report) + 75 (ext. examiner viva) + 75 (int. viva) + 50 (ext. guide)
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 2 of 29 SCAA Dt. 06.02.2014
SEMESTER- I
PAPER 1 INTRODUCTION TO ATOMIC AND NUCLEAR PHYSICS
Unit 1: Atomic structure of Matter
Thomson, Rutherford Model – Bohr’ Theory - Bohr’s theory of Hydrogen atom – Drawbacks of
these models – Bohr’s correspondence principle – Sommerfeld’s extension to Bohr model –
Frank and Hertz experiment – Types of spectra - Emission and absorption line spectra –
Fluorescence and Phosphorescence – Characteristics of vector atom model – Related Problems
Unit 2: Alkali spectra, space Quantization and Periodicity
Angular and magnetic momenta – Orbital angular momentum – Electron spin and quantum
number – Total angular momentum and magnetic moment of electron – Magnetic quantum
numbers – Spin Orbit interaction - LS Coupling Scheme – Selection rules – Pauli exclusion
principle – Electron configuration of atom – Periodic Table - Zeeman effect – Lande’s –g –
factor- Paschen Back effect – Stark effect – Stern Gerlach Experiment – Hyperfine structure of
spectral lines
Unit 3: Nuclear force ad Binding
Properties of Nuclear Force – Ground state properties of Deuteron – Square well solution of
Deuteron – Low energy neutron proton scattering - Limits of energy for the scattering of
different partial waves - Binding energy - Weizacker’s semi empirical mass formula –
Application of semi empirical formula for alpha decay – mass parabola for stability of nuclei
against beta decay - Evidence of shell effects – Single particle energy levels for infinite square
well, harmonic oscillator with spin orbit potential – Application of shell model for spin and
parity
Unit 4: Radioactive disintegration
Properties of radioactive rays – Law of radioactivity – Radioactive equilibrium -
Radioactive series - Range of alpha particles – Alpha spectrum and Fine structure - Alpha-
Particle Disintegration Energy- Gamow’s theory of Alpha decay – Energetics of Beta decay -
Beta-Ray Spectra- Pauli’s neutrino hypothesis – Properties of neutrino - Gamma emission –
Selection rules – internal conversion - Fssion process on the basis of liquid drop model - Nuclear
fission energetics - Stability limits against spontaneous fission – Potential for fission - Bohr-
Wheeler model -
Unit 5: Nuclear reactions
Types of nuclear reaction – Conservation laws in nuclear reactions – Balance of Mass and
Energy in nuclear reactions – The Q equation and its solution – Proton, deuteron, neutron and
alpha induced reactions – Cross section of nuclear reactions - Separation of center of mass
motion in two body problem – Partial wave method for scattering and reaction cross section –
Compound nucleus hypothesis – Breit Wigner one level formula
Text Book:
1. S. B. Patel , Nuclear Physics An Introduction – New Age International
2. S. N. Ghosal, Nuclear Physics, S. Chand
3. K.S. Krane, Introductory Nuclear Physics, Wiley India
4. D.C. Tayal, Nuclear Physics, Himalaya Publishing
5. S.L. Kakani and S. Kakani , Modern Physics, Viva Publications
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 3 of 29 SCAA Dt. 06.02.2014
PAPER 2 RADIATION PHYSICS
Unit 1: Ionizing radiation and Radiation Sources
Electromagnetic spectrum- Classification- Different sources of Non Ionizing radiation-
Radiofrequency, Microwaves, Infrared, Visible and Ultra violet radiation production, physical
properties and their interaction with tissues- Sources of ionizing radiation, properties, shielding
materials and medical applications.
Radiation sources: Natural and artificial radioactive sources – Large scale production of
isotopes – Reactor produced isotopes – Cyclotron produced isotopes – Fission products –
industrial uses– Description of radium and radium substitutes- Construction, production,
properties and decay scheme of Tele therapy sources- 37
Cs, 60
Co, 192
Ir, 125
I and other commonly
used brachytherapy sources– Gold seeds – Tantalum wire – Beta ray applicators –Thermal and
fast neutron sources– Preparation of tracers and labeled compounds – Preparation of ratio
colloids.
Unit 2: X-ray generator
X-ray generator: Discovery, production, properties of X-rays and X-ray spectra- History
of X-ray tubes – Basic requirements of medical diagnostic, therapeutic and industrial
radiographic tube – Rotating anode tubes – Hooded anode tubes – Industrial X-ray tubes – X-ray
tubes for crystallography – Rating of tubes – Safety devices in X-ray tubes – Ray proof and
shockproof tubes – Insulation and cooling of X-ray tubes – Mobile and dental units – Faults in
X-ray tubes – Limitations on loading.
Unit 3: Radiation Quantities and Units
Radiometry quantities: Particle flux and fluence, Energy flux and fluence, fluence rate,
Intensity. Interaction coefficients: Cross section, Linear and mass attenuation coefficients, Mass
energy transfer and mass energy absorption coefficients, Stopping power, Mass stopping power,
LET, Radiation chemical yield and W value. Radioactivity related quantities- activity, specific
activity etc. Dosimetry quantities– Energy imparted, absorbed dose, absorbed dose rate,
Exposure, Air kerma rate constant – Charged particle equilibrium (CPE), Relationship between
kerma, absorbed dose and exposure under CPE. Radiation protection quantities: Radiation and
tissue weighting factors, equivalent dose, effective dose, committed equivalent dose, committed
effected dose, Concepts of collective dose, KERMA, CEMA, Terma, Ambient and directional
dose equivalents [(H*(d) and H’(d)], individual dose equivalent penetrating Hp(d), Individual
dose equivalent superficial Hs(d).
Unit 4: Interaction of indirectly ionizing radiation with matter
Interaction of photons with matter- Exponential attenuation – Thomson scattering –
Photoelectric and Compton process and energy absorption – Pair production – Attenuation and
mass energy absorption coefficients – Relative importance of various processes.
Neutron classification, neutron sources, Interaction of neutrons with matter- Scattering,
absorption –Capture- Neutron induced nuclear reaction- radioactive capture reaction (n, p),(n, r)
etc- moderation- shielding materials.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 4 of 29 SCAA Dt. 06.02.2014
Unit 5: Interaction of directly ionizing radiation with matter
Interaction of charged particles with matter – Classical theory of inelastic collisions with
atomic electrons – Energy loss per ion pair by primary and secondary ionization – Dependence
of collision energy losses on the physical and chemical state of the absorber – Cerenkov
radiation – Electron absorption process – Scattering Excitation and Ionization – Radioactive
collision – Bremmstrahlung – Energy transfer mechanism, Bragg curve, Bethe Bloch Formula,
Passage of heavy charged particles through matter, specific ionization. Buildup correction,
shielding materials- Energy loss by collision- Range energy relation- Range energy relation –
Continuous slowing down approximation (CSDA) – straight ahead approximation and detour
factors – transmission and depth dependence methods for determination of particle penetration -
empirical relations between range and energy – Back scattering.
Books for references:
1. Oliver R. Radiation Physics in Radiology.
2. E.B.Podgarsak : "Radiation Physics for Medical Physicists" (Springer Verlag,1996)
3. H.E.Johns and Cunningham: " The Physics of radiology" ( Charles C Thomas Publishers)
4. E.B.Podgarsak : " Radiation Oncology Physics : Handbook for Teachers and Students" (
IAEA, Vienna)
5. F.H. Attix: "Introduction to Radiological Physics and Radiation Dosimetry" (Viley –
VCH, Verlog, 2004)
6. Curry,T.S. Dowdey and J.E. Murry,R.C : "Christensen’s introduction to the Physics of
diagnostic radiology " (Philadelphia,Lea& Febiger )
7. Chesney,D.N. & Chesney,M.O: “ X-ray equipment for student radiographers”
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 5 of 29 SCAA Dt. 06.02.2014
PAPER 3 ELECTRONICS
Unit 1: Analog Electronics
Zener diode- characteristics - voltage regulator circuits - Bipolar junction transistors - CB
and CE configuration characteristics. FET, MOSFET-principle of operation- characteristics -
JFET Amplifier. Op-Amp-circuit symbol-ideal Op-Amp- characteristics- CMRR- Applications:
Adder, Subtractor, Analog integrator, Analog differentiator, Voltage-to-current converter,
Current-to-voltage converter and Logarithmic amplifier.
Unit 2: Digital Electronics
Logic gates - Boolean algebra - Boolean laws – De-Morgans theorem -Implementation of
logic circuits from truth table – Sum-of-Products method – Products-of-Sum method –
Multiplexer and de-multiplexer circuits - BCD to Decimal decoders - Seven segment decoders -
Decimal to BCD encoder - Half-adder and Full-adder
Unit 3: Digital electronics
Types of Flip Flops: RS, Clocked RS, D-Flip Flop, Edge-triggered D Flip flop – J K Flip
flop - Master slave JK Flip flot - Sequential logic circuits:Types of registers– Serial in - Serial
out – Serial in – Parallel out – Parallel in Serial out – Parallel in Parallel out registers –
Applications - Counters: Ripple counters - up, down and up-down ripple counters -
Asynchronous and synchronous counters. A/D and D/A converters.
Unit 4: Microprocessors and Computer programming in C
8085A- architecture and pin configuration - basic 8085 instructions – assembly language
programming.
Constants – Varibles – Data types – operators and Expression – Input – output statements
– control statements functions – arrays – one, two, multidimensional array declarations and
initializations – simple applications.
Unit 5: X-ray generator circuits
Filament and high voltage transformers – High voltage circuits – Half-wave and full-
wave rectifiers – Condenser discharge apparatus – Three phase apparatus – Voltage doubling
circuits – current and voltage stabilizers – Automatic exposure control – Automatic Brightness
Control – Measuring instruments – Measurement of kV and mA – timers – Control panels –
Complete X-ray circuit – Image intensifiers and closed circuit TV systems – Modern Trends.
Books for references: 1. Santanue Chattopadhyay : "A text book of Electronics" (New Central Book Agency, Kolkata,
2006)
2. A.P. Malvino and D.P. Leach : "Digital Principles and Applications" (Tata McGraw-Hill
Publishing Co, New Delhi, 1996)
3. A.B. Bhattacharya : "Electronic Principles and Applications" (New Central Book Agency,
Kolkata, 2007)
4. Curry,T.S. Dowdey and J.E. Murry,R.C : "Christensen’s introduction to the Physics of
diagnostic radiology " (Philadelphia,Lea& Febiger )
5. A.P. Mathur : "Introduction to Microprocessors" (Tata McGraw-Hill Publishing Co, New
Delhi, 2005)
6. S.G. Kochan, “Programming in C”, CBS Publishers & Distributors, Delhi, 1991.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 6 of 29 SCAA Dt. 06.02.2014
PAPER 4 SOLID STATE PHYSICS
Unit – I: Crystal structure
Crystalline state- Basic definitions- Lattice and basis-Lattice translational vector-
Primitive cells and unit cells – Wigner –Seitz cell – Indexing of planes, directions and positions
of atoms-crystal systems – Bravais lattices - Simple crystal structures (Hexagonal close packed
structure, NaCl, CsCl, Diamond structure, Cubic ZnS structure)
X-ray diffraction – Laue’s treatment-Braggs treatment – Laue’s method-Rotating crystal
method-Powder method.
Unit – II: Thermal and Dielectric properties of solids
Dulong-Petits law – Einstein theory of specific heat – thermal conductivity – factors
affecting thermal conductivity
Basic definitions - Local field – Clausius Mossotti relation – Electronic, Ionic,
orientational and total polarizability – measurement of Dielectric constants and its measurements
Ferro electricity – Electrets – Hysteresis-Piezoelectricity - Applications.
Unit – III: Magnetic Properties of Materials
Terms and definitions used in magnetism – Classification of magnetic materials –
Langevin theory of diamagnetism – Langevin theory of paramagnetism - Quantum theory of
paramagnetism – Ferromagnetism – Spontaneous magnetization in ferromagnetic materials –
Hysteresis curve of ferromagnetic materials – origin of Ferromagnetic domains – Bloch wall -
Antiferromagnetism – Molecular field theory of antiferromagnetism – Ferrimagnetism.
Unit – IV: Superconductivity and Semiconducting properties of solids
Definitions: Critical temperature – critical magnetic field – Critical current – Persistent
current - The Meissner effect – Type 1 and 2 superconductors – Intermediate state – Vortex state
- London equations –BCS theory –DC and AC Josephesen effect - Applications.
Semiconductors - Direct and indirect band gaps – Classification of semiconductors –
Concentration of electrons in the conduction band – hole concentration in the valence band –
Electrical conductivity in semiconductors
Unit – V: Optical Properties
Absorption processes- Photoconductivity – Photoelectric effect – Photovoltaic effect –
Photoluminescene – Thermoluminescence – Flouresecnce – Radioluminesce- Phosphorescence
Colour centres – Types of colour centres – F-Centre - Generation of colour centres.
MASER and LASER
Books for references:
1. Solid state Physics – R.J.Singh, Pearson, 2012 Edition
2. Solid State Physics: Structure and Properties of Materials, 2nd
Ed. A.M.Wahab, Narosa
Publishing house, New Delhi, India, 2007.
3. Elementary Solid State Physics: Principles and Applications, 4th
Ed., M.A.Omar, Pearson
Education Pvt. Ltd., Delhi, India, 2004.
4. Introduction to Solid State Physics, 7th
Ed, C. Kittel, John –Wiley & Sons (Asia) Pvt Ltd.,
New Delhi, 1996.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 7 of 29 SCAA Dt. 06.02.2014
5. Elements of Solid State Physics 2nd
Ed, J.P.Srivastava, Printice Hall of India, New Delhi,
2001.
6. Solid State Physics, 4th
Ed. S.O.Pillai, New Age International Publishers, New Delhi,
2001.
7. Solid State Physics, 1st Ed, Ashcroft and Mermin, Eastern Press Pvt Ltd, Bangalore,
2003.
8. Introductory to Solid State Physics 2nd
Ed, H.P.Myers, Taylors and Francis Ltd, London,
1998.
Tutorials: 1. In an intrinsic semiconductor, the effective mass of an electron is 0.07 mo and that of hole
is 0.4 mo, where mo is the rest mass of the electron. Calculate the intrinsic concentration
of charge carriers at 300 K. (Given the energy gap = 0.7 eV)
2. If a sample of silicon is doped with 3 x 1023
arsenic atoms and 5 x 1023
atoms of boron.
Determine the electron and hole concentrations if the intrinsic charge carriers of silicon
are 2 x 1016
/ m3
3. The polarizability of NH3 molecule in the gaseous state, from the measurement of
dielectric constant is found to be 2.42 x 10-39
Fm2 at 309 K and 2 x 10
-39 Fm
2 at 448 K,
respectively. Calculate for each temperature the polarizability due to permanent dipole
moment and due to deformation of molecules.
4. The magnetic field intensity in a piece of ferric oxide is 106 ampere/metre. If the
susceptibility of the material at room temperature is 1.5 x 10-3
, calculate the flux density
and magnetization of the materials.
5. The critical temperature for mercury with isotopic mass 199.5 is 4.185K. Calculate its
critical temperature when its isotopic mass changes top 203.4
6. The penetration depths for lead are 396 Ao and 1730 A
o at 3 K and 7.1K, respectively.
Calculate the critical temperature for lead.
7. Diamond (atomic weight of carbon = 12) has Youngs modulus of 1012
Nm-2
and a density
of 3500 kg/m3. Compute the Debye temperature for diamond.
8. A photon of wavelength 1400 Ao is absorbed by cold mercury vapour and two other
phonons are emitted. If the wavelength of one of them is 1850 Ao, what is the wavelength
of the other photon?
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 8 of 29 SCAA Dt. 06.02.2014
PAPER 5
APPLIED ANATOMY AND PHYSIOLOGY
Unit 1: Structure & function of organs, systems & their common diseases
Skin, Lymphatic system, Bone and muscle, Nervous, Endocrine, Cardiovascular,
Respiratory, Digestive (Gastro-Intestinal), Urinary, Reproductive, Eye and ear.
Unit 2: Basic, Radiographic anatomy and tumor pathology
Anatomy of human body, nomenclature & Surface anatomy, Radiographic Anatomy
(including cross sectional anatomy – Identify the different organs/structures on plain x-rays, CT
scans and other available imaging modalities. Normal anatomy & deviation for abnormalities.
Tumor pathology and carcinogenesis, common pathological features of cancers and
interpretation of clinico-pathological data.
Unit 3: Clinical aspects of Radiation Oncology
Radiation therapy, Surgery, Chemotherapy, Hormone Therapy, Immunotherapy &
Radionuclide therapy, Benign and malignant disease, Methods of spread of malignant disease,
Staging and grading systems, Treatment intent – Curative & Palliative, Cancer prevention and
public education and Early detection & Screening. Patient management on treatment – side
effects related to radiation and dose – Acute & Late – Monitoring and common management of
side effects – Information and communication.
Unit 4: Site specific signs, symptoms, diagnosis and management
Head and Neck, Breast, Gynecological, Gastro-Intestinal tract, Genito-Urinary, Lung &
Thorax, Lymphomas & Leukemias & Other cancers including AIDS related cancers.
Unit 5: Professional aspects and role of medical physicists
General patient care - Principles of professional practice – Medical terminology –
Research & professional writing – patient privacy – Ethical & cultural issues. Legal aspects –
Confidentiality, informed consent, Health and safety.
Books for references:
1. Meschan. Normal Radiation Anatomy
2. Hollinshead W.H. Text Book of Anatomy
3. ROD R. Seely. Idho State University “Anatomy and Physiology” Eight Edition
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 9 of 29 SCAA Dt. 06.02.2014
PRACTICALS
ELECTRONICS LAB
(Any 15 experiments only)
1. Zener regulated power supply and percentage of regulation.
2. Transistor characteristics- CB configuration.
3. Transistor characteristics- CE configuration.
4. Single stage R-C coupled transistor amplifier.
5. FET characteristics.
6. Single stage FET amplifier- CS configuration.
7. OP-Amp applications- Adder, Subtractor, Differentiator and Integrator.
8. Logic gates OR, AND, NOT, NOR and NAND Gates.
9. NAND gate as a universal gate.
10. Half adder and Full adder.
11. A/D and D/A converters.
12. Programs using C
13. Programs using MATLAB.
14. Programs using MATHEMATICA.
15. Programs using STATISTICA.
16. Characterization of Photosensitive diodes and heel effect.
17. Statistics of Radioactive Counting
18. Determination of plateau and revolving time of a G.M. counter and its application in
estimating the shelf-ratio and activity of a beta sources.
19. Calibration of gamma ray spectrometer and identification of unknown sources.
20. Find the detection efficiency of GM counters for both Gamma and beta emitting Sources.
21. Determination of Linear and Mass attenuation coefficients for Al, Cu and Pb.
22. Spectral analysis of Cs source using Gamma ray spectrometer
23. Attenuation of X/Gamma rays through different materials and HVL analysis.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 10 of 29 SCAA Dt. 06.02.2014
SEMESTER- II
PAPER 6
STATISTICAL AND NUMERICAL METHODS
Unit 1: Probability, Statistics and Errors
Addition and multiplication laws of probability, conditional probability, population,
variants, collection, tabulation and graphical representation of data -Frequency distributions,
Measures of central tendency, arithmetic mean, properties of arithmetic mean, median, mode,
geometric mean, harmonic mean, dispersion, standard deviation, root mean square deviation,
standard error and variance, moments, skewness and kurtosis - Binomial, Poisson, Gaussian
distributions – Correlation and Regression, Chi-Square distribution
Unit 2: Counting and medical statistics Statistics of nuclear counting-Application of Poisson’s statistics – Goodness-of-fit tests –
lexie`s divergence coefficients - Statistical aspects of gamma ray and beta ray counting – Special
consideration in gas counting and counting with proportional counters – Statistical accuracy in
double isotope technique. Sampling and sampling distributions – confidence intervals - Clinical
study designs and clinical trials - Hypothesis testing and errors Application to radiation detection
– uncertainty calculations, error propagation, time distribution between background and sample,
minimum detectable limit.
Unit 3: Roots of equation and Interpolation
Bisection – False position method – Newton Raphson method – Gauss elimination mehod -
Gauss Jacobi method – Gauss Seidal method – Inversion of a matrix using Gauss elimination
method - LU decomposition - Gregory Newton’s forward and backward difference formula for
equal intervals – Divided difference – Properties of divided difference – Newton’s divided
difference formula – Lagranges interpolation formula for unequal intervals
Unit 4: Curve fitting, integration, and monte carlo methods
Method of least squares – straight line, parabola, y=axn, y=ae
bx, y=a+bx
n types of curves - Sum
of squares of residuals for straight line and parabola – Newton-Cotes method - Trapezoidal rule,
Simpson’s 1/3rd
rule-Simpson’s Three-Eight rule, Boole rule, Weddle rule. Monte Carlo Method
vs Deterministics Method - Generation of random numbers- Test for randomness- Discrete and
continuous Random variables- Solving simple integrals using different Monte Carlo techniques -
law of large numbers - the central limit theorem - variance reduction techniques.
Unit 5: Eigen values and differential equation
Power method to find dominant eigen value – Jacobi method (Only 2x2 and 3x3 matrices) –
Initial value problem – Taylor series method – Basic, Improved and Modified Euler methods –
Runge Kutta Fourth Order method – RK4 method for simultaneous differential equations – RK4
method for second order differential equation – Partial differential equation – difference –
quotients – Graphical representation of partial quotients – Classification of differential equations
– Standard and five point diagonal formula – Liebmann’s iteration process.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 11 of 29 SCAA Dt. 06.02.2014
REFERENCES
1. Hoffman. Numerical Methods for Engineers and scientists – 2nd
Edition Revised and
Expanded, Marcel Dekker Inc.., 270 Madison Avenue, blew York, NY 10016, Marcel
Dekker AG, Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland.
2. A.C. Bajpai, I.M. calus and J.A. Fairley Numerical Methods for Engineers and scientists
– A students course book, John Wiley &sons
3. Band W. Introduction to mathematical physics.
4. Croxton. Elementary Statistics .
5. Dahlberg G. Statistical Method of Medical & Biology students.
6. S.S.Sastry, "Introductory Methods of Numerical Analysis", Prentice Hall of India,New
Delhi, 1992.
7. T. Veerarajan and T. Ramachandran , “Numerical Methods wit programs in C”, Tata
Mcgraw Hill
8. W. R. Leo, Techniques for Nuclear and Particle Physics Experiments, Narosa, New Delhi
(1995)
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 12 of 29 SCAA Dt. 06.02.2014
PAPER 7
RADIATION DETECTORS AND INSTRUMENTATION
Unit 1: Principles of Radiation Detection- Gas filled detectors
Basic Principles of radiation detection– Statistical nature of radiation emission, errors,
accuracy and precision of measurements, types of errors- Gas Filled detectors – Ionisation
chambers – Theory and design – Construction of condenser type chambers and thimble chambers
– Gas multiplication – Proportional and GM Counters – Characteristics of organic and inorganic
counters – Dead time and recovery time – quenching.
Unit 2: Principles of Radiation Detection- scintillation and other solid state detectors
Scintillation detectors– Different types, the relationship between pulse height and energy
and type of incident particle, photomultiplier tube, assembly of a scintillation counter and role of
light pipes, dead time of scintillation counters, sources of background in a scintillation counter,
resolving time, resolving power- Semiconductor detectors – different types, damage due to
radiation- Chemical systems. Radiographic and Radio chromic films – Thermo luminescent
Dosimeters (TLD) – Common TLD materials, characteristics, fading, residual TL and annealing
for reuse, detection process, glow curve and dose response- Diode detectors- Optically
stimulated Luminescence dosimeters (OSLD) – Radiophoto luminescent dosimeters-
comparison between all solid state detectors- Neutron Detectors – Nuclear track emulsions for
fast neutrons – Solid State Nuclear track (SSNTD) detectors – calorimeters – New
Developments.
Unit 3: Dosimetry Instruments
Dosimeters based on condenser chambers – Pocket chambers – Dosimeters based on
current measurement – Different types of electrometers – MOSFET, Vibrating condenser and
Varactor bridge types – Secondary standard therapy level dosimeters – Farmers Dosimeters –
Radiation field analyzer (RFA) – Radioisotope calibrator – Multipurpose dosimeters – Water
phantom dosimetry systems – Brachytheraphy dosimeters – Thermo luminescent dosimeter
readers for medical applications – Calibration and maintenance of dosimeters.
Unit 4: Radiation Protection instruments
Instruments for personnel monitoring – TLD badge readers – PM film densitometers –
Glass dosimeters readers - Digital pocket dosimeters using solid state devices and GM counters –
Teledetector – industrial gamma radiography survey meter – Gamma area (Zone) alarm monitors
- Contamination monitors for alpha, beta and gamma radiation – Hand and Foot monitors
_Laundry and Portal Monitors - Scintillation monitors for X and gamma radiations - Neutron
Monitors, Tissue equivalent survey meters – Flux meter and dose equivalent monitors – Pocket
neutron monitors -Teledose systems.
Unit 5: Nuclear Medicine instruments
Instruments for counting and spectrometry – Portable counting systems for alpha and beta
radiation – Gamma ray spectrometers – Multichannel Analyzer – Liquid scintillation counting
system – RIA counters – Whole body counters – Air Monitors for radioactive particulates and
gases. Details of commercially available instruments and systems.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 13 of 29 SCAA Dt. 06.02.2014
Books for references:
1. Price W.J. Nuclear Radiation Detection
2. Stepanor B.I. Theory Of Luminescence
3. Glenn F Knoll. Radiation Detection & Measurement
4. Albert Paul Malvino. Electronics Principles
5. Robert L. Boylestad. Electronics Devices And Circuit Theory
6. Paul-Horowitz. Art of Electronics
7. Greiner R.A. Semiconductor Devices & Application
PAPER 8 MEDICAL IMAGING TECHNOLOGY
Unit 1: Physical principle and components of Radiography
Physical Principle: Interactions of X-rays with human body, differential transmission of
x-ray beam, spatial image formation, visualization of spatial image, factors influencing
resolution evaluation of resolution - limitations, of projection imaging technique Viz.
superimposition of overlying structures and scatter, application of contrast media and projections
at different angles to overcome superimposition of overlying structures.
Filters: inherent and added filters, purpose of added filters, beryllium filter, filters used
for shaping X-ray spectrum (K-edge filters: holmium, gadolinium, molybdenum). Scatter
reduction: Factors influencing scatter radiation, objectives of scatter reduction, contrast reduction
factor, scatter reduction methods: beam restrictors (diaphragms, cones/cylinders & collimators),
grids (grids function, different types of stationary grids, grid performance evaluation parameters,
moving grids, artifacts caused by grids, grid selection criteria), air gap technique. Intensifying
screens: Function of intensifying screens, function evaluation parameters, emission spectra and
screen film matching, conventional screens a Vs rare-earth screens. Radiographic Film:
Components of radiographic film, physical principles of image formation on film, double and
single emulsion film, sensitometeric parameters of film (density, speed, latitude etc.,).
Unit 2: Conventional and digital radiography techniques Conventional Radiography techniques: Prime factors (kVp, mAs and SID/SFD),
influence of prime factors on image quality, selection criterica of prime factors for different
types of imaging, different type of projection and slices selected for imaging, objectives of
radio-diagnosis, patient dose Vs image quality.
Mammography and fluoroscopy: AEC. Compression Paddle, HVL- Modern tends in
interventional Radiology- Bi- Plane imaging, rotational angiography, cardiac imaging real time
imaging characteristics – continuous and pulsed fluoroscopy, high dose rate fluoroscopy, Dose
area product (DAP) meters, peak skin dose, dose management for pediatric and pregnant patient
in interventional imaging, Diagnostic Reference Level and guidelines.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 14 of 29 SCAA Dt. 06.02.2014
Xero-radiography, C- arm, Interventional radiology, digital radiography (CR and DR
systems), digital subtraction techniques, Conventional tomography and orthopan tomography
(OPG) (principle only).
Unit 3: Computed Tomography
Conventional X-ray tomography (Basic principle), Data Accumulation, Original EMI
Scanner, Scanning motions or Generations- First, Second, Third and fourth Generations,
Principle of Helical CT Scan and Scan Parameters (kV, mA.S and pitch)-Other scan
configurations-X-ray tubes, Collimators, Detectors-Scintillation crystal and Xenon Gas
Ionization chamber, Image reconstruction, Modes of CT acquisition, Axial acquisition, Helical
acquisition, Cone beam acquisition, Cardiac CT, CT angiography, CT perfusion – Cone beam
reconstruction, Iterative reconstruction, postprocesing tools, volume rendering, SSD, MPR, MIP-
factor affecting patient dose CTDI, CTDI vol, CTDI w dose length product (DLP), multiple scan
average dose (MSAD). Algorithms for Image reconstruction- Back projection, Iterative method
and Analytical methods, Comparison of Mathematical models, CT Numbers, Image display,
Image quality, Resolution-Spatial and contrast resolution, Patient exposure, Artifacts-Motion
artefacts, Streak artefacts, Beam hardening artefacts and Ring artefacts, 3D Imaging –Surface
reconstruction and Volumetric reconstruction.
Unit 4: Magnetic Resonance Imaging (MRI) and Ultrasound Imaging
Magnetic Resonance image – Hydrogen characteristics, magnetization vector, Precession,
flip angle. proton density, relaxation time T1 & T2 images – Comparison of T1 and T2- image
characteristics – MRI system components – Magnets, Magnetic fields, Gradients, Magnetic field
shielding, Radio Frequency systems, MR signal localization, composite signal, K-space – Basic
MR imaging sequences, MR instrument and bio safety, image quality- MRI safety.
Interaction of sound waves with body tissues, production of ultrasound – Transducer
array – Beam Properties – Near field-far side lobes-spatial resolution. Image data acquisition –
data acquisition system, ADC- receiver, Echo display modes, scan converter. Image data
acquisition, pulse echo acquisition – ultrasound image display, amplitude mode, Motion mode,
brightness mode- ultrasound image quality – image artifacts – Bio effects of ultrasound- colour
Doppler.
Unit 5: Safety in Diagnostic Radiology
General considerations in design of diagnostic installations- QA of conventional
diagnostic X- ray equipment: purpose of QA, QA Protocols, QA Test methods for performance
evaluation of diagnostic equipments – Collimator congruence test; accuracy of kVp; HVL,
accuracy of mAs; consistency of output; accuracy of mA; small and large Focal Sport size
evaluation, radiation safety survey conventional and interventional radiographic systems,
phantom test in digital radiography. QA in CT. Other related quality assurance as per the
guidelines of the AERB as part of regulation. QA in mammography using phantoms.
Performance testing and quality assurance in ultrasound and MRI using accredited phantoms.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 15 of 29 SCAA Dt. 06.02.2014
Books for references:
1. Curry, T.S., Dowdey, J.E., Murry, R.C., (1990), Christensen’s introduction to the
physics of diagnostic radiology (4th
ed.), Philadelphia: Lea & Febiger.
2. Bushberg, S.T., Seibert, J.A, Leidholt, E.M. & Boone, J.M. (1994), The essential
physics of medical imaging, Baltimore: Williams & Wilkins.
3. Dendy, P.P. & Heaton, B. (2nd
ed), physics for diagnostic radiology, Bristol &
Philadelphia: Institute of physics Publishing.
4. Johns, H.E. & Cunningham, J.R. (1983), The physics of radiology (4th
ed.), Springfield,
IL: Charles C. Thomas
5. E. Seeram. X-ray imaging equipment, An introduction (1985), Springfield, IL : Charles
C. Thomas.
6. Hendee, W.R. & Ritenour, R. (1983), Medical Imaging physics (3rd
ed.), St. Louis:
C.V. Mosbey.
7. Chesney, D.N. & Chesney, M.O., X-ray equipment for student radiographers (3rd
ed.),
New Delhi: CBS Publishers & Distributors.
8. Chesney, D.N. & Chesney, M.O., Radiographic imaging (4th
ed.), New Delhi: CBS
Publishers & Distributors.
9. Hashemi, R.H., Bradley, W.G. & Lisanti, C.J. MRI the basics, Philadelphia: Lippincot
Williams & Willkins.
10. Sprawls, P., Magnetic resonance imaging principles, methods and techniques, Madison
Wisconsin: Medical Physics Publishing.
PAPER 9
EXTERNAL BEAM RADIATION THERAPY
Unit 1: Beam generators
Kilo voltage therapy X-ray Units: principle and application of Grenz ray therapy -
contact therapy, superficial therapy, orthovoltage, deep therapy.
Telecobalt units: Construction and working, source design, beam shutter mechanisms,
mercury shutter pneumatic pressure system, rotating wheel shutter system, beam collimation,
penumbra and it's types, trimmers and breast cones, isocentric gantry.
Particle accelerators: Particle accelerators for industrial, medical and research
applications - The Resonant transformer – Cascade generator – Van De Graff Generator –
pelletron – Cyclotron – Betatron - Synchro – Cyclotron – Microtron - Electron Synchrotron –
Proton synchrotron. Linear accelerator- Details of accelerators facilities in India, Construction
and working, klystron and magnetron, traveling and standing waveguide, pulse modulators and
auxiliary systems, bending magnet systems, treatment beam production - X-rays - electron
beam, beam collimation, asymmetric collimator, multileaf collimator, dose monitoring and beam
stabilization - electron contamination- relative merits and demerits of kV x-rays, gamma rays,
MV x-rays and electron beams.
Unit 2: Dosimetry parameters
Central axis dosimetry parameters: percentage depth doses (PDD), tissue air ratio
(TAR), back scatter factor/Peak scatter factor (BSF/PSF) - tissue phantom ratio (TPR) - tissue
maximum ratio (TMR)- collimator scatter factor, phantom scatter factor and total scatter factors -
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relationship between TAR and PDD and its applications - relationship between TMR and PDD
and its applications – scatter air ratio(SAR) – scatter maximum ratio(SMR)- off axis ratio field
factors- surface dose and buildup region- Tissue equivalent phantoms- Radiation Field Analyzer
(RFA)- Description and measurement of isodose curves/ charts- Dosimetry data resources.
Unit 3: Beam modifiers and treatment planning
Beam modifying and shaping devices – Block Cutting machines- wedge filters –
universal, motorized and dynamic wedges - treatment planning with wedges– shielding blocks -
field shaping, custom blocking - tissue compensation – design of compensators, 2D
compensators, 3D compensators-special considerations in treatment planning - skin dose, field
matching, integral dose, DVHs – differential, integral.
Treatment planning in teletherepy – target volume definition and dose prescription
criteria – Gross tumor volume (GTV), Clinical target volume (CTV), Internal target volume
(ITV), Internal margin, Planning target volume (PTV), Organ At Risk (OAR), Treated volume,
Irradiated volume, Maximum target dose, Median target dose, Modal target dose and hot spot.
ICRU 50, ICRU 62 and ICRU 83- SSD and SAD set ups – two and three dimensational
localization techniques, dose specification and normalization- Positioning/immobilization - 2D
and 3D simulation techniques- conventional simulator- CT simulator- use of contrast, markers -
patient data acquisition- contours, contouring images from CR, CT, MRI, US, PET, fusion
techniques - virtual simulation – digitally reconstructed radiographs(DRR).
Field arrangements – single, parallel opposed and multiple fields – corrections for tissue
in homogeneity, contour shapes and beam obliquity – integral dose. Arc/rotation therapy and
Clarkson technique for irregular fields – mantle and inverted Y Fields. Conventional and
conformal radiotherapy. Treatment time and Monitor unit calculations- SSD and SAD/isocentric
technique, Co-60 and accelerator calculations.
Unit 4: Physics of electron and particulate beam therapy
Clinical electron beams – energy specification – electron energy selection for patient
treatment – depth dose characteristic (Ds, Dx, R100, R50, Rp etc.) – beam flatness and symmetry –
penumbra – isodose plots – monitor unit calculations – output factor formalisms – effect of air
gap on beam dosimetry – effective SSD.
Relative merits of electrons, neutron, x-ray and gamma ray beams and heavily charged
particles – Neutron capture therapy and Heavy ion (proton and carbon ion) therapy- physical
principle and equipment only.
Unit 5: Quality assurance in radiation therapy
Quality assurance in radiation therapy – precision and accuracy in clinical dosimetry -
quality assurance protocols for telecobalt, medical linear accelerator and radiotherapy
simulators– IEC requirements – acceptance, commissioning and quality control of telecobalt,
medical linear accelerator and radiotherapy simulators. Portal and in-vivo dosimetry. Electronic
portal imaging devices.
Books for references:
1. W.R.Hendee, Medical Radiation Physics, Year Book Medical Publishers Inc., London,
1981.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 17 of 29 SCAA Dt. 06.02.2014
2. R.F.Mould, Radiotherapy Treatment Planning, Medical Physics Hand Book Series No.7,
Adam Hilger Ltd.,Bristor, 1981.
3. S.C.Klevenhagen, Physics of Electron Beam Therapy, Medical Physics Hand Book
Series No.6, Adam Hilger Ltd.,Bristor, 1981.
4. G.C.Bentel, Radiation Therapy Planning, Macmillan Publishing Co.,New York, 1992.
5. Govinda Rajan, Advanced Medical Radiation Dosimetry, Prentice hall of India Pvt.Ltd.,
New Delhi, 1992.
6. H.E. Johns and Cunningham. The physics of radiology.
7. Faiz M. Khan, The Physics of radiation therapy, Lippincott Williams & Willkins,
Philadelphia, 3rd
edition, 2003.
8. Faiz M. Khan, Roger A. Potish, Treatment planning in Radiation Oncology, Williams &
Willkins, Baltimore, 1998.
9. S.H. Levitt, J.A. Purdy, C.A. Perez and S.Vijayakumar (Editors). Technical Basis of
Radiation Therapy practical Clinical Applications – 4th
Revised Edition, Springer Berlin
Heidelberg New York.
PAPER 10
RADIATION DOSIMETRY AND STANDARDIZATION
Unit 1: Dosimetry & Standardization of X and Gamma Ray Beam
Standards – Primary and Secondary Standards, Traceability, Uncertainly in measurement.
Charged Particle Equilibrium (CPE), Free Air Ion Chamber (FAIC), Design of parallel plate
FAIC, Measurement of Air Kerma/ Exposure with effective SSD. Limitations of FAIC. Bragg-
Gray theory, Mathematical expression describing Bragg-Gray principle and its derivation.
Burlin and Spencer Attix Cavity theories. Transient Charged particle Equilibrium (TCPE),
Concept of Dgas, Cavity ion chambers, Derivation of an expression for sensitivity of a cavity ion
chamber. General definition of calibration factor – Nx, Nk, ND, air, ND, w. IAEA TRS277:
Various steps to arrive at the expression for Dw starting from Nx. TRS398: ND, w, Q : ND, W :
KQ,Q0 : KQ, Derivation of an expression for KQ,Q0. Calorimetric standards –AAPM TG 51 and
other dosimetric protocols- Intercomparison of standard.
Unit 2: Measurement of Dw for beams from telecobalt machines and for electrons from
linac
Measurement of Dw for External beams from 60
Co teletherapy machines: Reference
conditions for measurement, Type of ion chambers, phantom, Waterproof sleeve, Derivation of
an expression for Machine Timing error, Procedure for evolution of Temperature and pressure
correction : Thermometers and pressure gauges. Measurement of temperature and pressure.
Saturation correction: derivation of expression for charge collection efficiency of an ion chamber
based on Mie theory. Parallel plate, cylindrical and spherical ion chambers, Ksat, Two voltage
method for continuous and pulsed beams Polarity correction.
Measurement of Dw for high-energy Electrons beams (TRS 381) from Linear
accelerators: Beam quality, beam quality index, beam quality correction coefficient, Cross
calibration using intermediate beam quality and depth dose characteristics. Quality Audit
Programmes in Reference and Non-Reference conditions.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
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Unit 3: Neutron Standards & Dosimetry
Neutron standards – primary standards, secondary standards, Neutron yield and fluence
rate measurements, Manganese sulpate bath system, precision long counter, Activation method.
Neutron spectrometry, threshold detectors, scintillation detectors & multispheres, Neutron
dosimetry, Neutron survey meters, calibration, neutron field around medical accelerators.
Unit 4: Standardization of Radionuclides
Methods of Measurement of radioactivity – Defined solid angle and 4Л counting – Beta
gamma coincidence counting – Standardization of beat emitters and electron capture nuclides
with proportional, GM and scintillation counters – Standardization of gamma emitters with
scintillation spectrometers – Ionization chamber methods – Extrapolation chamber – Routine
sample measurements – Liquid counter – Windowless counting of liquid samples – scintillation
counting methods for alpha, beta and gamma emitter – Reentrant ionization chamber methods –
Methods using (n, ŕ) and (n, p) reactions – Determination of yields of neutron sources – Space
integration methods – Solids state detectors.
Unit 5: Radiation Chemistry and Chemical Dosimetry
Definition of free radicals and G-Values-Kinetics of radiation chemical transformations –
LET and dose-rate effects – Radiation chemistry of water and aqueous solutions, peroxy radicals,
pH effects – Radiation Chemistry of gases and reactions of dosimetry interest – Radiation
polymerization, effects of radiation on polymers and their applications in dosimetry – Formation
of free radicals in solids and their application in dosimetry- Description of irradiators from
dosimetric view point – Dosimetry principles – Definitions of optical density, molar absorption
coefficient, Beer – Lamberts law, spectrophotometry – Dose calculations - – Laboratory
techniques – Reagents and procedures _ Requirements for an ideal chemical dosimeter – Fricke
dosimeter – FBX dosimeter – Free radical dosimeter – Ceric sulphate dosimeter – Other high and
low level dosimeters – Applications of chemical dosimeters in Radiotherapy and industrial
irradiators.
Books for references:
1. Joseph Margill and Jean Galy. Radioactivity Radionuclide Radiation, European,
Commission Joint Research Centre, Institute of Transuranium Elements, P. O. Box 2340,
76125 Karlsruhe, Germany.
2. IAEA TRS 374, Calibration of Dosimeters used in Radiation Therapy.
3. F.H. Attix. Introduction to Radiological Physics and Radiation Dosimetry, Viley - VCH,
Verlog, 2004.
4. Field. Clinical Use of Radioisotopes.
5. W.R.Hendee, Medical Radiation Physics, Year Book Medical Publishers Inc., London,
1981.
6. S.C.Klevenhagen, Physics of Electron Beam Therapy, Medical Physics Hand Book
Series No.6, Adam Hilger Ltd., Bristol, 1981.
7. G.C.Bentel, Radiation Therapy Planning, Macmillan Publishing Co.,New York, 1992.
8. Govinda Rajan, Advanced Medical Radiation Dosimetry, Prentice hall of India Pvt.Ltd.,
New Delhi, 1992.
9. IAEA TRS 277, “Absorbed dose determination in Photon and Electron beams”.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 19 of 29 SCAA Dt. 06.02.2014
PRACTICALS
MEDICAL PHYSICS LAB - I
Suggested New Practicals:
(1) Attenuation of Gamma rays through various materials and evaluation of HVL
(2) Study of Voltage-Current Characteristics of a Ion Chamber
(3) Measurement and Verification of PDD, TAR and TMR values
(4) Determination of output of a telecobalt unit - Using TRS 398
(5) Wedge and Tray factor determination
(6) Manual monitor unit calculations of simple and complex treatment plans
(7) Quality Assurance of a Telecobalt unit
(8) Quality Assurance of a Treatment Planning System
(9) Quality Assurance of a Linear Accelerator
(10) Autoradiography test for Brachytherapy source in Remote Afterloader unit
(11) Quality Assurance of a Radiography or CT
Demonstrations:
(1) Treatment Planning for External Beam with TPS
(2) Treatment Planning for Brachytherapy with TPS
(3) Demonstration of In-air Scanner
SEMESTER- III
PAPER 11
BRACHYTHERAPY AND COMPUTERS IN TREATMENT PLANNING
Unit 1: Brachytheraphy physics and dosimetry
Definition and classification of brachytherphy techniques – surface mould, intracavitary,
interstitial, intraluminal and intraoperative techniques. Requirement for brachytherapy sources-
Dose rate considerations and classification of brachytheraphy techniques – Low dose rate (LDR),
medium dose rate (MDR), high dose rate (HDR) and pulsed dose rate (PDR).
Paterson parker and Manchester Dosage systems. ICRU 38 and 58 protocols.
Specification and calibration of brachytheraphy sources - RAKR and AKS – IAEA TECDOC
1274 and ICRU 72 recommendations. Point and line source dosimetry formalisms – Sievert
Integral – AAPM TG-43/43U1 and other dosimetry formalisms.
Unit 2: Afterloading techniques
Afterloading techniques – Advantages and disadvantages of manual and remote
afterloading techniques. AAPM and IEC requirements for remote afterloading brachytheraphy
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 20 of 29 SCAA Dt. 06.02.2014
equipment. Acceptance, commissioning and quality assurance of remote after loading
brachytheraphy equipment. ISO requirements and QA and Standardization of Brachtherapy
sources – Apparent activity – Reference Air Kerma Rate – Air Kerma Strength – Standards for
HDR 192
Ir and 60
CO sources – Standardization of 125
I and beta sources – IAEA TECDOC 1274 –
room scatter correction. Calibration of protection level instruments and monitors- Integrated
brachytherpahy unit.
Manual pre loading systems: Manual after loading systems - remote after loading systems
-source trains (fixed and programmable) - stepping source - different types of applicators
(gynecological, esophageal, nasopharngeal, bronchial) and templates.
Unit 3: Treatment planning and quality assurance in brachytherapy
Brachytherapy treatment planning – Radiography, CT, MRI based brachytheraphy
planning – forward and inverse planning. Networking: DICOM and PACS (in detail)- DICOM
image import/export from OT – Record & Verification.
Acceptance and commissioning Test, Quality Assurance (QA) and Quality Control (QC)
of radiotherapy (teletherapy and brachytherapy) treatment planning systems using IAEA TRS
430 and other protocols.
Unit 4: Advances in Brachytherapy
Brachytheraphy treatment for prostate cancer. Ocular brachytherphy using photon and
beta sources. Intravascular brachytheraphy – classification – sources – dosimetry procedures -
AAPM TG 60 protocol. Electronic brachytheraphy (Axxent, Mammosite, Etc.)
Unit 5: Computers in Treatment Planning
Scope of computers in radiation treatment planning – Review of algorithms used for
treatment planning computations – pencil beam, double pencil beam, Clarkson method,
convolution superposition, lung interface algorithm, fast Fourier transform, Inverse planning
algorithm, Monte Carlo based algorithms. Treatment planning calculations for photon beam,
electron beam, and brachytherapy – Factors to be incorporated in computational algorithms. Plan
optimization – direct aperture optimization – beamlet optimization – simulated annealing – dose
volume histograms – Indices used for plan comparisons – Hardware and software requirements –
beam & source library generation- Networking, DICOM and PACS (overview).
Books for references:
1. D. Baltas, L. Sakelliou and N. Zamboglou The Physics of Modern Brachytherapy for
Oncology CRC Press, Taylor and Francis Group, 6000 Brooken Sound Parkway NW
Suite 300, Boca Raton – FL 33487-2742.
2. Faiz M. Khan, The Physics of radiation therapy, Lippincott Williams & Willkins,
Philadelphia, 3rd
edition, 2003.
3. T.J.Godden, “Physical aspects of brachytherapy”.
4. Subir Nag “Principles and Practice of Brachytheraphy”.
5. S.H. Levitt, J.A. Purdy, C.A. Perez and S.Vijayakumar (Editors). Technical Basis of
Radiation Therapy practical Clinical Applications – 4th
Revised Edition, Springer Berlin
Heidelberg New York.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 21 of 29 SCAA Dt. 06.02.2014
PAPER 12
RADIATION BIOLOGY
Unit 1: Cell Biology
Cell Physiology and biochemistry – Structures of the normal- nature of cancer cells-
transport of ions through cell membrance- Types of cells and tissue, their structures and
functions - Organic constituents of cells – Carbohydrates, fats, proteins and nucleic acids –
Enzymes and their functions – Functions of mitochondria, ribosomes, golgi bodies and
lysosomes – Cell metabolism – DNA as concepts of gene and gene action – Mitotic and meiotic
cell division – Semi conservative DNA synthesis, Genetic variation Crossing over, mutation,
chromosome segregation – Heredity and its mechanisms.
Unit 2: Interaction of Radiation with Cells
Concepts of micro dosimetry- Direct and indirect action of radiation on living cells –
Radiolytic products of water and their interaction with biomolecule – Nucleic acids, proteins,
enzymes, fats – Influence of oxygen, temperature – Cellular effects of radiation – inactivations,
Mitotic delay, DNA damage, chromosome aberrations, mutations and recombinations – Giant
cell formation, cell death Recovery from radiation damage – Potentially lethal damage and
sublethal damage recovery - Pathways for repair of radiation damage. Law of Bergonie and
Tribondeau- radio sensitivity protocol of different tissues in human.
Unit 3: Radiobiological models
Cell survival curve parameters – in vitro and in vivo experiments on mammalian cell
systems- Model for radiation action – Target theory – Single hit Single target – Single hit Multi
target - Single hit and Multi hit target theory– Multi hit Single target – Multi hit Multi target -
other theories of cell inactivation- Repair misrepair hypothesis – Dual action hypothesis –
Modification of radiation damage – RBE, LET, OER, dose rate, dose fractionation – Oxygen and
other chemical sensitizers – Anoxic, hypoxic, base analogs, folic acid, and energy metabolism
inhibitors – Hyperthermic sensitization – Radio-protective agents- effects of UV, microwave and
other non-ionizing radiation.
Unit 4: Biological Effects of Radiation
Somatic effects of radiation – Physical factors influencing somatic effects – Dependence
on dose, dose rate, type and energy of radiation, temperature, anoxia, - Acute radiation sickness –
LD 50/30 and LD 50/60 dose – Effects of radiation on skin and blood forming organs, blood
constituents, embryo, digestive track, endocrine glands, gonads– Sterility and cataract formation
– Effects of chronic exposure to radiation – Induction of leukemia – Radiation Carcinogenesis –
Risk of carcinogenesis – Animal and human data – Shortening of life span – In-utero exposure.
Genetic effects of radiation – Threshold and linear dose-effects relationship- Factors
affecting frequency of radiation induced mutations– first generation effects – Effects due to
mutation of recessive and dominant characteristics – Genetic burden – gene controlled hereditary
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Page 22 of 29 SCAA Dt. 06.02.2014
diseases and defects – Spontaneous mutation rate – human data on animals and lower species-
Concept of doubling dose and genetic risk estimate.
Unit 5: Biological Basis of Radiotherapy
Physical and biological factors affecting cell survival, tumor regrowth and normal tissue
response – Non-conventional fractionation scheme and their effect of reoxygenation, repair,
redistribution in the cell cycle – High LET radiation therapy.
Time dose fractionation – Basis for dose fractionation in beam therapy – Concepts for
Nominal Standard Dose (NSD), Roentgen equivalent therapy (RET) – Time dose fractionation
(TDF) factors and cumulative radiation effects (CRE) – Gap correction, Linear and Linear
Quadratic models, TCP and NTCP evaluation- problem of hypoxic compartment and quiescent
cells- radiobiology of malignant neoplasm- solution of hypoxic cell sensitizers, hyperthermia,
combination of chemotherapy and radiotherapy- chronoradiobiology and its applications to get
better cure- problem of tumor regression.
Books for references:
1. E. J. Hall, Radiobiology for Radiologists, J. B. Lippincott Co., Philadelphia, 2000.
2. S. P. Yarmonenko, Radiobiology of Humans and animals, MIR, Publishers,
Moscow,1990.
3. Late biological effects of ionizing radiation: proceedings of the Symposium on the Late
Biological Effects of Ionizing Radiation held by the International Atomic Energy Agency
in Vienna, 13-17 March 1978.
4. H. Smith, J. W. Stather, Biological effects of ionising radiation, Landolt-Börnstein-
Group VIII Advanced Materials and Technologies Volume 4, 2005, pp 5-40.
5. Dr. Claus Grupen Biological Effects of Ionizing Radiation Graduate Texts in Physics
2010, pp 212-228.
6. B. Kanyár, G. J. Köteles, Dosimetry and Biological Effects of Ionizing Radiation,
Handbook of Nuclear Chemistry 2011, pp 2211-2257.
7. IAEA TRS 42, Radiation Biology: A handbook for teachers and students, 2010.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
Page 23 of 29 SCAA Dt. 06.02.2014
PAPER 13
NUCLEAR MEDICINE AND INTERNAL DOSIMETRY
Unit 1: Physics of Nuclear Medicine, In-vivo and In-vitro techniques
Introduction to nuclear Medicine, Unsealed Sources, production of Radionuclide used in
Nuclear Medicine; Reactor based Radionuclide, Accelerators based Radionuclide, photonuclear
activation, Equations for Radionuclide production, Radionuclide Generators and their operation
principles. Various usages of Radiopharmaceuticals.
In-vivo non-imaging procedures: Thyroid Uptake Measurements, Reno gram, Life Span
of RBC, Blood Volume studies, life Span of RBC etc. General concept of Radionuclide,
imaging and Historical developments. In-vitro Techniques: RIA/IRMA techniques and its
principles. Difference between in-vivo and in- vitro dosimetry.
Unit 2: Components of radionuclide imaging
Radionuclide Imaging: Other techniques and Instruments; The Rectilinear Scanner and its
operational principles, Basic Principles and Design of the Anger Camera / Scintillation Camera;
System components, Detector System and Electronics, Different types of Collimators, Design
and performance Characteristic of the Converging, Diverging and Pin hole collimator, Image
Display and Recording Systems, Digital Image processing Systems, Scanning Camera,
Limitation of the Detector System and Electronics.
Unit 3: Different imaging techniques and their image quality parameters
Different Imaging Techniques: Basic Principles, Two dimensional Imaging Techniques,
Three Dimensional Imaging techniques – Basic principles and Problems, Focal plane
Tomography, Emission Computed Tomography, Single Photon Emission Computed
Tomography, Positron Emission Tomography. Various Image Reconstruction Techniques during
Image formation such as Back projection and Fourier based Techniques, Iterative Reconstruction
method and their drawbacks. Attenuation Correction, Scatter Correction, Resolution Correction,
Other requirements or Sources of Error.
Image Quality Parameters: Spatial Resolution, Factor affecting spatial Resolution,
Methods of Evaluation of spatial Resolution, Contrast, Noise. NEMA protocols followed for
quality Assurance / Quality Control of Imaging Instruments.
Unit 4: Physics of PET and Cyclotron
Principles of PET, PET Instrumentations, Annihilation Coincidence Detection, PET
Detector Scanner Design, Data Acquisition for PET, Data corrections and Quantitative Aspect of
PET, Working of Medical Cyclotron, Radioisotopes produced and their characteristic. Treatment
of Thyrotoxicosis, Thyroid cancer with I-131, use of P-32 and Y-90 for palliative treatment,
Radiation Synovectomy and the isotopes used. se of open isotopes including 99Tc in functional
studies, measurement of radio activity, principle of isotope dilution analysis, circulation time,
patient dose, guidance level, production principles and decontamination procedures.
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Page 24 of 29 SCAA Dt. 06.02.2014
Unit 5: Internal Dosimetry
Different Compartmental Model; Single Compartmental Model, Two Compartmental
Model with Back Transference, Two Compartmental Model without Back Transference.
Classical Methods of Dose Evaluation: Beta particle Dosimetry; Equilibrium Dose Rate
Equation, Beta Dose Calculation Specific Gamma Ray constant, Gamma Ray Dosimetry,
Geometrical Factor Calculation, Dosimetry of Low energy Electromagnetic Radiation.
MIRD Technique for Dose calculations; Basic producer and some practical problems,
Cumulative Activity, Equilibrium Dose Constant, Absorbed Fraction, Specific Absorbed
Fraction, Dose Reciprocity Theorem, Mean Dose per unit Cumulative Activity and problems
related to the Dose calculations. Limitation of MIRD Technique.
Books for references:
1. Simon R. Cherry, James A., Sorenson, Michael E. Phels, Physics in nuclear Medicine
(3rd
ed.), SAUNDERS an imprint of Elsevier.
2. Ramesh Chandra, Nuclear Medicine physics (5th
ed.), Lea & Febiger, Philadelphia.
3. Antonio Fernando Goncalves Rocha and john Charles Harbert, Text Book of Nuclear
Medicine: Basic Science, Lea & Febiger, Philadelphia.
4. Pail J. Early, M.A. Razzak and D, Bruces Sodee, Text Book of Nuclear Medicine
Technology. The C.V. Mosby Company.
5. A.L. Baert and K. Sartor, Diagnostic Nuclear Medicine (2nd
ed.), Springer.
6. Gopal B. saha, Fundamental of Nuclear Pharmacy (5th
ed.), Springer.
7. Dale L. Bailey, David W. Townsend, Peter E. Valk and Michael N. Maisey. Springer.
Janet F. Eary and Winfried Brenner, Nuclear Medicine Therapy. Informa Health
Care.
8. J.K Fowler, Nuclear Particles in Cancer Treatment, Adam Hilger Ltd., Philadelphia,
1981.
9. W.H.Blahd, Nuclear medicine, McGraw Hill Co., New Delhi 1980.
10. W.N.Wagner, Principles of Nuclear Medicine, W.B.Saunders Co., London 1970.
11. J.Herbert and D.A.Rocha, Text Book of Nuclear Medicine, Vol 2 and 6, Lea and
Febiger Co., Philadelphia, 1984.
12. S.Webb, The Physics of Medical Imaging, Medical Science Series, Adam Hilgers
Publications, Bristol, 1984.
M.Sc. Medical Physics (UD) 2014-15 onwards Annexure No. 74 A
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PAPER 14
RADIATION HAZARDS EVALUATION AND CONTROL
Unit 1: Radiation protection standards
Radiation dose to individuals from natural radioactivity in the environment and man-
made sources. Basic concepts of radiation protection standards – Historical background –
International Commission on Radiological protection and its recommendations – The system of
Radiological protection – Justification of practice, Optimization of protection and individual
dose limits– potential exposures, dose and constraints – System of protection for intervention –
Categories of exposures – Occupational, Public and Medical Exposures – risk factor- permissible
levels for neutron flux –Factors governing internal exposure – Radionuclide concentrations in air
and water – ALI, DAC and contamination levels-international/national radiation protection
standards-ICRP, BSS and AERB, overview of UNSCEAR recommendations.
Unit 2: Principles of Monitoring and Protection and safety in industry
RPR 2004- Evaluation of external radiation hazards – Effects of distance, time and
shielding – shielding calculations – Personnel and area monitoring – Internal radiation hazards –
Radio toxicity of different radionuclide and classification of laboratories – Control of
contamination – Bioassay and air monitoring – chemical protection – Radiation accidents –
disaster monitoring.
Safety in Industrial, Agricultural and Research uses of Radiation: Use of ionizing
radiation in irradiator, industrial; radiography, nucleonic gauging, well logging and research such
as medical research, industrial research and agricultural research.
Unit 3: Safety in the Medical Uses of Radiation
Planning and shielding calculations of medical radiation installation – General
considerations – Design of diagnostic installations- design of deep therapy, telegamma,
accelerators and Brachytherapy installations, SPECT, PET/CT, Medical Cyclotron in the Nuclear
Medicine Department and medical radioisotope laboratories- Evaluation of radiation hazards in
medical diagnostic therapeutic installations – Radiation monitoring procedures – Protective
measures to reduce radiation exposure to staff and patients – Radiation hazards in brachytherapy
department and teletherapy departments and radioisotope laboratories – Particle accelerators
protective equipment – Handling of patients – Radiation safety during sources transfer
operations special safety features in accelerators, reactors.
Unit 4: Radioactive Waste Disposable and Transport of Radioisotopes
Radioactive Waste – sources of radioactive waste – Classification of waste – Treatment
techniques for solid, liquid and gaseous effluents – Concept of Delay Tank and Various Waste
Disposal Methods used in Nuclear Medicine. Permissible limits for disposal of waste – sampling
techniques for air, water and solids – Geological, hydrological and meteorological parameters –
Ecological considerations. Disposal of radioactive wastes – General methods of disposal.
Transportation of radioactive substances – Historical background – General packing
requirements – Transports documents – Labeling and marking of packages – Regulations
applicable for different modes of transport – Transports by post –Transport emergencies –
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Special requirements for transport of large radioactive sources and fissile materials – Exemptions
from regulations – shipments approval – Shipment exclusive use – Transports under special
arrangement – Consignors and carriers responsibilities.
Unit 5: Legislation and Radiation Emergencies and their Medical Management
Physical protection of sources – Safety and security of sources during storage, use,
transport and disposal – Security provisions: administrative and technical – Security threat and
graded approach in security provisions.
National legislation – Regulatory framework – Atomic Energy Act – Atomic Energy
(Radiation Protection) Rules – Applicable safety codes, standards, Guides and Manuals –
Regulatory Control – Licensing, inspection and Enforcement – Responsibilities of Employers,
Licensees, Radiological Safety Officers and Radiation workers – National Inventories of
radiation sources – Import, Export procedures.
Radiation accidents and emergencies in the use of radiation sources and equipment
industry and medicine - Radiographic cameras and teletherapy units – Loading and unloading of
sources – Loss of Radiation sources and their tracing – Typical accidents cases, Radiation
injuries, their treatment and medical management – Case his histories.
Books for references:
1. Herman Cember. Introduction to Health Physics
2. Atomic Energy Act 1962
3. AERB Radiation Production Rules 2004
4. ICRP 1990 Recommendations
5. ICRP 2007 Recommendations
6. IAEA Basis Safety Standards 115, 1997
7. Shapiro J. Radiation Protection
8. Mckenzie. Radiation protection in Radiotherapy
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PAPER 15
RECENT ADVANCES IN RADIOTHERAPY
Unit 1: Conformal and Intensity modulated radiotherapy
Introduction to CRT with MLC-Modern developments in MLC – Different categories of
MLC – Leaf position detection – commercially available MLC systems– MLC acceptance,
commissioning and safety assessment – clinical application- Quality assurance.
Introduction to IMRT – physical optimization – Biological models for evaluation and
optimization of IMRT – Target and critical structure definitions for IMRT – Static MLC IMRT,
Dynamic MLC IMRT, compensator based IMRT –potential problems with IMRT –
Commissioning and QA for IMRT treatment planning –patient specific quality assurance– IMRT
delivery system quality assurance.
Unit 2: Stereotactic radiosurgry/radiotherophy (SRS/SRT)
Stereotactic radiosurgry/radiotherophy (SRS/SRT) – cone and mMLC based X-Knife –
Gamma Knife – immobilization devices for SRS/SRT – dosimetry and planning procedures –
Evaluation of SRS/SRT treatment plans – QA protocols and procedure for X- and Gamma Knife
units – Patient specific QA. Physical, planning clinical aspects and quality assurance of
stereotactic body radiotherapy (SBRT) and Cyber Knife based therapy.
Unit 3: Image Guided Radiation Therapy (IGRT)
Concept, imaging modality, kVCBCT and MVCBCT. Mechanics of breathing – Methods
to manage respiratory motion in radiation treatment – x-ray imaging techniques for guidance in
the Radiation therapy setting – clinical procedures in employing x-ray imaging technologies. –
Effect of motion on the total dose distribution – 4D computed tomography imaging and
treatment planning. Delivery- QA protocol and procedures.
Unit 4: Volumetric modulated arc therapy
Introduction- Machine Commissioning and Quality Assurance- Dosimetric Aspects-
Treatment Planning- Comparison of VMAT treatment plans with conventional IMRT planning-
Patient Specific Quality Assurance- Electronic Portal Imaging device– its clinical applications
including QA tool in machine and patient specific quality assurance and gamma index analysis.
Unit 5: Special techniques in radiation therapy
Total Body Irradiation, hemi body irradiation, Total Skin Electron Therapy, electron arc
treatment, intraoperative radiotherapy- principle, equipment, treatment planning, dosimetry,
quality assurance and commissioning.
Neutron capture therapy- Heavy ion therapy (proton and carbon ion)- dosimetry (AAPM
Report No 16), treatment planning, quality assurance and commissioning.
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Books for references:
1. Steve Webb, The Physics of Three–Dimensional Radiotherapy, Institute of Physics
Publishing, Bristol and Philadelphia, 2002.
2. Faiz M Khan and Roger A Potish, Treatment Planning in Radiation Oncology, Williams
and Wilkins, USA, 2003.
3. S. Webb. The physics of conformal radiotherapy, Institute of Physics publishing,
Philadelphia, 1997.
4. S. Webb. Intensity Modulated radiation therapy, Institute of Physics publishing,
Philadelphia, 2001.
5. J. Van Dyk, The Modern Technology of Radiation Oncology, Medical Physics
Publishing, Madison, WI, 1999.
6. Faiz M Khan , The Physics of Radiation Therapy, 3rd edition, Lippincott Williams &
Wilkins, USA, 2003.
7. Jatinder R Palta and T. Rockwell Mackie, Intensity Modulation Radiation Therapy,
Medical Physics publishing, Madison , Wisconsin, 2003.
8. Thomas Bortfeld. Rupert Schmidt-Ullrich, Willfried De Neve. David E.Wazer (Editors).
Image-Guided IMRT. Springer Berlin Heidelberg, 2006.
9. AAPM Report No. 72 , Basic Applications of Multileaf collimators, AAPM, USA, 2001.
10. AAPM Report No: 91, Management of Respiratory motion in radiation oncology, 2006.
11. David M. Hailey, Australian Institute of Health, High Energy Radiotherapy Equipment:
A Discussion Paper, Australian Institute of Health, 1989.
12. J.F.Fowler, Nuclear Particles in Cancer Treatment, Adam Hilger Ltd., Philadelphia, Pa,
1981.
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PRACTICALS
MEDICAL PHYSICS LAB - II
Suggested New Practicals:
1. Cross Calibration of Ion Chambers
2. Absolute Calibration of Photon and Electron beams - using TRS 398
3. Evaluation of Profile parameters using Radiation Field Analyzer
4. Manual Treatment Planning of Single and Parallel Opposed fields
5. Manual Treatment Planning of Three and Four fields
6. Quality Assurance of Multileaf Collimator
7. Quality Assurance of a Brachytherapy unit
8. Calibration of Film Scanner
9. Pretreatment IMRT Quality Assurance
10. Radiation Protection survey of Teletherapy and Brachytherapy installations
Demonstrations:
(1) Nuclear Medicine uptake studies
(2) Gamma Camera demonstration
(3) Demonstration of Linear Detector Array