Annual Report of the

Department of Molecular & Integrative

Physiology

University of Kansas Medical Center

July 1, 2015-June 30, 2016

The image on the cover shows the new logo that the Physiology Department developed in May-June 2016. This replaces our old logo, which the design was outdated. The new logo, in the KU colors, shows the acronym of our Department (MIP, Molecular and Integrative Physiology) and captures the global study of the physiology of the human body as represented by the modified letter “P”. Also, the logo gives the idea of a magnifying lens exploring cells. The logo was designed by A. Blanco. This logo is intended only for internal use in the Department of Molecular & Integrative Physiology.

TABLE OF CONTENTS Year in Review ………………………………………………………3 Department Roster ………………………………………………….11 Graduate Student Activities ……….……………………………….17 Courses Taught ……………………………………………………...27 Department Seminars ……………………………………………….29 Publications

a. Published (7/1/15-6/30/16) ………………………………35

b. In Press …………………………………………………….41 c. Abstracts …………………………………………………..42

Research Support …………………………………………………….45 Faculty Activities ……………………………………………………….49

1

2

3

YEAR IN REVIEW 2015-2016

The Department of Molecular and Integrative Physiology has continued under the leadership of Dr. V. Gustavo Blanco, who served as Interim Chair. During this past year, the Department has continued to hold up well, despite the continuing difficult funding environment at the Federal and State levels. There have been some changes with respect to the Department’s size. As expected, two Faculty members have retired. In addition, two transferred to the Surgery Department and another one obtained a position in another University. Research programs in the various areas have continued vibrant and the Department has maintained a consistent level of publications. Also, the Department has had another important year with respect to teaching. In the medical curriculum, the Department has maintained its long lasting presence in the Cardiopulmonary and Renal-Endocrine modules. Dr. John Wood and Dr. Michael Wolfe, who lead these modules, have played an instrumental role in leading these sections of the curriculum. In addition, several of our Faculty has been recognized with important teaching awards for their efforts in medical education. Our Faculty has also continued playing a major role in the core IGPBS curriculum and they have been teaching different Advanced Physiology courses. The outstanding teaching reviews from the students show the commitment of our Faculty to high quality teaching, something that we are always very proud of. Regarding service, our Department has continued contributing by serving in numerous key committees at our University, which are essential to the mission of our School. At the national and international level, our Faculty has: 1) served on different review panels from the National Institutes of Health and other funding agencies, 2) participated on editorial boards for different journals, and 3) have disseminated the work performed in our Department through presentations at other Universities as invited speakers, and at national and international meetings. We are very grateful to our faculty, who with their talent and hard work, have continued maintaining the academic success of our Department during the 2015-2016 period.

It is also important to highlight the excellent support that the Department received from our office staff, despite a reduction in personnel in this area. Special thanks go to our Senior Administrator, Shari Standiferd for her continuous dedication and hard work.

We would like to specifically recognize our benefactor and continuous supporter, Jim Osborn, as well as his wife Marion, and his daughter Kathleen. His generous contributions over the years have significantly contributed to our success. The Kathleen M. Osborn Endowed Chair, the Marion M. Osborn Professorship, and the lectureship in honor of Kathleen M. Osborn that Jim established have made a great difference to our Department. All members of our Department immensely appreciate the exceptional support of Jim Osborn and his family.

4

HIGHLIGHTS FROM THE 2015-2016 ACADEMIC YEAR

RESEARCH FUNDING: Most of our research programs are supported by major external funding. This is something that we are proud of, especially taking into consideration the extremely difficult current funding environment. We owe this to the dedication of our Faculty, who has continued crafting high quality research grant proposals. Based on data provided by KUMC Enterprise Analytics, total NIH funding was $3,765,688, which is lower than that of last year ($4,223,748). The latest data available shows that our Department was ranked 42nd at the national level for NIH research funding among 82 medical schools receiving NIH funding. While this is a good position for our Department, we would like to improve this ranking. Based on data obtained from QlikView, during fiscal year 2016, grant requests from the Department indicated total costs of $34,667,506 (which included a $26,143,005 in direct costs and $8,524,501 in indirect costs). From these, $30,549,185 corresponded to grant proposals submitted to the National Institutes of Health.

EDUCATION: Continuing a long lasting tradition, the Physiology Department has had another outstanding year with respect to teaching. As mentioned previously, Dr. John Wood and Dr. Michael Wolfe led two key modules of the medical curriculum, the Cardiopulmonary and Renal-Endocrine modules. The Cardiopulmonary module received from the medical students an award for being the best module, presented to

James & Marion Osborn Kathleen Osborn

5

the Department at the “Grande Affair” celebration on March 21, 2015. At this same event, two of our Faculty members, Dr. John Wood and Dr. Gustavo Blanco were recognized with ”Student Voice Awards” for their excellence in teaching. These awards are a testimony of the long lasting commitment of our Faculty members to education.

TENURE TRACK APPOINTMENTS: No new primary tenure track appointments were made this year. We have however new appointments from Stowers Institute of Medical Research. These include: Randal Halfmann, Ph.D., started as Assistant Professor on April 1, 2016. His research focuses on determining the mechanisms by which proteins assemble to form polymers or aggregates. Nicolas Rohner, Ph.D., started as Assistant Professor on December 1, 2015. His work involves the study of genetic basis of adaptation to environmental changes, focusing on metabolism. RESEARCH TRACK APPOINTMENTS: E. Matthew Morris, Ph.D., was appointed as Research Assistant Professor, beginning on July 1, 2016. Dr. Morris investigates the role of liver energy metabolism in the development of obesity, type-2 diabetes, and cardiovascular disease. JOINT AND ADJUNCT APPOINTMENTS: The following researchers received joint appointments at their current ranks, after they moved from their primary appointments in Physiology. Shawn Frost, Ph.D., Research Assistant Professor. Transferred to Rehabilitation Medicine on July 1, 2015. Shrikant Anant, Ph.D., Professor, started on January 3, 2016, after transferring to the Surgery Department. Shahid Umar, Ph.D., Associate Professor, started on January 3, 2016 after transferring to the Surgery Department. FACULTY PROMOTIONS: Dr. Vargheese Chennathukuzhi was promoted to Associate Professor with tenure starting July 1, 2015. We are very pleased of Dr. Chennathukuzhi’s accomplishments. Following his recruitment to the Department, he has developed a well-funded research program and he has built a strong research group. His research is directed to understanding the molecular mechanism by which uterine leiomyomas are produced. His research seeks to find small molecule inhibitors of pathways involved in uterine fibroid growth.

6

FACULTY/STAFF DEPARTURES: There have been several departures from our Department. Reasons for departure include, retirements, transfers to other departments, and one Faculty accepted a position at another University. Among the Faculty who retired are: David Albertini, Ph.D. finished his phased retirement period and fully retired on June 30, 2016. He was recruited to KUMC on June 6, 2004. His research was focused on human and animal reproduction with special emphasis on the translation of basic science into the treatment of human infertility. He served as the Director of the Center for Reproductive Sciences in our Institution. We thank Dr. Albertini for his 12 years of service in our Department and wish him the best in his retirement. Norberto C. Gonzalez, M.D., retired on January 3, 2016. He joined the Physiology Department on September 8, 1970. Since then, his research was directed to understand the molecular mechanisms of adaptation of intact organisms to alveolar hypoxia, a condition that commonly occurs in altitude, or in some types of pulmonary disease. Dr. Gonzalez had a stellar career at KUMC. He is not only a renowned investigator nationally and internationally, but also he is an outstanding teacher, who has contributed immensely to the educational mission of our Department. We wish him the best retirement after his 44 ½ years of dedicated service. The following members of the Department made transitions to other KUMC departments: Shrikant Anant, Ph.D., Professor, transferred to the Surgery Department on January 3, 2016. Dr. Anant continues working in the area of cancer and he maintains a joint appointment with our Department. Shahid Umar, Ph.D., Associate Professor, also transferred to the Surgery Department on January 3, 2016. He is also working in the area of cancer, with emphasis in colon cancer and maintains a joint appointment with our Department. Prabhu Ramamoorthy, Ph.D., Research Assistant Professor, transferred to Surgery on January 3, 2016. Dharmalingam Subramaniam, Ph.D., Research Assistant Professor, transferred to Surgery on January 3, 2016. Satish Ramalingam, Ph.D., Research Assistant Professor, departed on August 25, 2015 and returned to India. Shawn Frost, Ph.D., Research Assistant Professor, transferred to Rehabilitation Medicine on July 1, 2015 and maintains a joint appointment with our Department. Among our Stowers Affiliate Faculty, Rong Li, Ph.D., Professor, departed on July, 2015 to start at Johns Hopkins University in Baltimore, MD. One of our Faculty, T. Rajendra Kumar, Ph.D., Professor, was recruited by the University of Colorado Medical Center. He left on April 30, 2016. He served as the

7

Director of the Center for Reproductive Sciences at KUMC. He now obtains a position as Professor & Associate Vice-Chair of Research in the Department of Obstetrics & Gynecology at the University of Colorado Medical Center in Aurora, Colorado. FACULTY AWARDS/ACCOMPLISHMENTS: Numerous members of our Department have been serving on review panels from NIH and other agencies. They have also served on the editorial board of different journals and presented invited lectures at national and international meetings. Dr. Lane Christenson has been involved with the organization of the research program for the Society for the Study of Reproduction annual meeting. GRADUATE PROGRAM AND PHYSIOLOGY SOCIETY: The student led Physiology Society continued functioning well this year. A new President was elected and a new committee was chosen. The leadership of the Physiology Society is currently the following: Joshua Curry, President Asona Lui, Vice-President Mina Farahbakhsh, Social Chair Younshim Park, Stowers Chair The graduate students in the department had another active year. In 2015-2016 three new students were recruited to the department. These include students who are working with our affiliate members at Stowers Research Institute. Currently, our Department has a total of 28 enrolled doctoral students. Several of our students were able to obtain external fellowships to support their training. Funding came from different sources, including the SELF Fellowship program, the KUMC Biomedical Training Program, NSF, and NIH. The new graduate students that joined the Department in the fall of 2015 included the following individuals (their respective mentors are listed in parenthesis): Zahraa Alali (Dr. Warren Nothnick) Younshim Park (Dr. Kausik Si) Afreen Sayed (Dr. Shrikant Anant) The Cancer Biology program was formally approved by the Kansas Board of Regents and students from our Department moved to Cancer Biology in 2016. These include: Eric Young (Dr. Danny Welch), transferred on January 2016 Afreen Sayed (Dr. Shrikant Anant), transferred on June 2016 Wahid Mulla and Akshay Narkar (Dr. Rong Li) transferred with their mentor to Johns Hopkins in August 2015. Five students completed their PhD degrees during the fall of 2015 and the spring of 2016. Congratulations to all of them and their mentors. These are listed below:

8

Summer 2015 Fall 2015 Spring 2016 No Graduates Mohammed Khan – PhD Swathi Iyer - PhD Robert Rogers - PhD Danny Miller – PhD Nairita Roy - PhD Mohammed Khan, Ph.D. (August 19, 2015) received his degree with Dr. Si. The title of his dissertation was “Role of Drosophila ORB2 (CPEB) in Synaptic Protein Synthesis”. Dr. Khan is now a Postdoctoral Fellow with Dr. Valina Dawson at Johns Hopkins University in Baltimore, MD. Robert Rogers, Ph.D. (September 1, 2015) received his degree with Dr. Geiger. The title of his dissertation was “Heat Shock Proteins in Metabolic Disease – Skeletal Muscle, Liver and Adipose Tissue Cross Talk”. Dr. Rogers is now a Postdoctoral Fellow in Dr. Hiroshi Nishimune’s research lab in the Anatomy and Cell Biology department of KUMC. Nairita Roy, Ph.D. (November 10, 2015) received her degree with Dr. Swerdlow. The title of her dissertation was “Investigating the Presence of Mitochondrial DNA Methylation, Its Alteration and Association with Mitochondrial Transcription and Mitochondrial Function”. Dr. Roy is now working as a Postdoctoral Fellow at the University of Pittsburgh, PA. Swathi Iyer, Ph.D. (March 24, 2016) received her degree with Dr. Iwakuma. The title of her dissertation was “Roles of TMIGD3 and A3AR in the Suppression of Osteosarcoma Malignancy”. Dr. Iyer is currently working as a Postdoctoral Fellow in Dr. Tomoo Iwakuma’s research lab in Cancer Biology at KUMC. Danny Miller, Ph.D. (April 4, 2016) received his degree with Dr. Scott Hawley from Stowers. The title of his dissertation was “A Genomic Analysis of Meiosis in Drosophila Melanogaster”. Dr. Miller is working on his MD degree at KU Medical Center. Prepared by:

V. Gustavo Blanco, MD/PhD Professor and Interim Chair

9

Department of Molecular & Integrative Physiology Faculty 2015-2016

(Left to right): Andrei Belousov, Paige Geiger, E. Matthew Morris, John Thyfault, Lane Christenson, Steven LeVine (back), Melissa Larson (front), Leslie Heckert, Warren Nothnick, Vargheese Chennathukuzhi, Gustavo Blanco, Sam Enna, Peter Smith Not Pictured: Paul Cheney, Phil Lee, John Stanford, Joseph S. Tash, Michael W. Wolfe, John G.

Wood, Sumedha Gunewardena, David Albertini, Shrikant Anant, T. Rajendra Kumar,

Shahid Umar, Shawn Frost, Satish Ramalingam, Prabhu Ramamoorthy, Dharmalingam

Subramaniam

10

Department of Molecular & Integrative Physiology Graduate Students 2015-2016

Front Row (left to right): Younshim Park, Asona Lui, Jessica Venugopal Back Row (left to right): Jianzheng Wu, Margaret Pruitt, Joshua Curry, Ashley Archer, Mina Farahbakhsh Not Pictured: Zahraa Alali, Amanda Brinker, Li Chen, Blake Ebner, Cameron Fox, Kelsey Hampton, Wei-Ting Hung, Liying Li, John McGinnis, Michelle McWilliams, Zelha Nil, Archana Raman, Amy Cantilena, Swathi Iyer, Mohammed Khan, Danny Miller, Lei Pei, Robert Rogers, Nairita Roy, Afreen Sayed, Eric Young, Chuankai Zhou

11

DEPARTMENT ROSTER July 1, 2015 – June 30, 2016

a. Faculty

Primary Appointment in Physiology V. Gustavo Blanco, M.D., Ph.D., Professor & Interim Chair David F. Albertini, Ph.D., Professor Shrikant Anant, Ph.D., Professor; Tom and Teresa Walsh Professor of Cancer Prevention; Eminent Scholar, Kansas Bioscence Authority; Associate

Director for Prevention and Cancer Control Andrei Belousov, Ph.D., Associate Professor Paul D. Cheney, Ph.D., Professor Vargheese M. Chennathukuzhi, Ph.D., Associate Professor Lane K. Christenson, Ph.D., Associate Professor Salvatore J. Enna, Ph.D., Professor; Associate Dean for Research and Graduate Education Paige C. Geiger, Ph.D., Associate Professor Leslie L. Heckert, Ph.D., Marion M. Osborn Professor for Reproductive Sciences T. Rajendra Kumar, Ph.D., Professor, Director of the Center for Reproductive Sciences Phil Lee, Ph.D., Associate Professor Steven M. LeVine, Ph.D., Professor Warren Nothnick, Ph.D., Professor Peter G. Smith, Ph.D., Professor, Director of the Institute for Neurological

Disorders, Co-Director of the Kansas Intellectual and Developmental Disabilities Research Center, Senior Associate Dean for Research

John A. Stanford, Ph.D., Associate Professor Joseph S. Tash, Ph.D., Professor

John P. Thyfault, Ph.D., FACSM, Associate Professor Shahid Umar, Ph.D., Associate Professor Michael W. Wolfe, Ph.D., Associate Professor John G. Wood, Ph.D., Associate Professor Emeritus Lawrence P. Sullivan, Ph.D., Professor Thomas J. Imig, Ph.D., Professor Paul F. Terranova, Ph.D., Professor James L. Voogt, Ph.D., Professor Norberto C. Gonzalez, M.D., Professor Stowers Affiliates Peter Baumann, Ph.D., Professor Scott Hawley, Ph.D., Professor Sue Jaspersen, Ph.D., Associate Professor Kausik Si, Ph.D., Associate Professor Randal Halfmann, Ph.D, Assistant Professor

12

Stowers Affiliates (continued) Nicolas Rohner, Ph.D, Assistant Professor Research Track Faculty Shawn Frost, Ph.D., Research Assistant Professor. Sumedha Gunewardena, D.Phil., Research Assistant Professor Melissa Larson, Ph.D., Research Assistant Professor & Director of

Transgenic Facility Satish Ramalingam, Ph.D., Research Assistant Professor. Prabhu Ramamoorthy, Ph.D., Research Assistant Professor. Dharmalingam Subramaniam, Ph.D., Research Assistant Professor. E. Matthew Morris, Ph.D., Research Assistant Professor. Beginning on July 1,

2016 Joint Appointment in Physiology Shrikant Anant, Ph.D., Professor of Surgery, Vice Chair of Surgery Research

Richard Barohn, M.D., Professor (Chair, Neurology) Sandra Billinger, PT, Ph.D., FAHA, Associate Professor (Physical

Therapy and Rehabilitation Science) William Brooks, Ph.D., Professor (Neurology, Director of Hoglund Brain Imaging Center) Jeffrey Burns, M.D., Professor (Neurology, Director of Alzheimer and

Memory Center & Alzheimer’s Disease Clinical Research Program) Mark Chertoff, Ph.D., Associate Professor (Hearing & Speech)

In-Young Choi, Ph.D., Associate Professor (Neurology & Hoglund Brain Imaging Center)

Buddhadeb Dawn, M.D., Professor (Internal Medicine, Director of Cardiovascular Research Institute and Division of Cardiovascular Disease)

Animesh Dhar, Ph.D., Associate Professor (Cancer Biology) Navneet Dhillon, PhD., Associate Professor (Pulmonary and Critical Care

Medicine) Dan Dixon, Ph.D., Associate Professor (Cancer Biology) Shawn Frost, Ph.D., Research Assistant Professor (Rehabilitation Medicine) Tomoo Iwakuma, M.D., Ph.D., Associate Professor (Cancer Biology) Jill Jacobson, M.D., Professor (Pediatrics)

Benyi Li, Ph.D., Associate Professor (Urology) Joan Lewis-Wambi,Ph.D., Assistant Professor (Cancer Biology) Joshua Mammen, M.D., Associate Professor (General Surgery) Ajay Nangia, M.B.B.S., FACS, Associate Professor (Urology Surgery) Jules Nazzaro, M.D., Associate Professor (Neurosurgery) Randolph Nudo, Ph.D., Processor and Vice Chair or Research (Rehabilitation

Medicine) Janet Pierce, D.S.N., ARNP, CCRN, Professor (School of Nursing) Jeff Radel, Ph.D., Associate Professor (Occupational Therapy) Cary Savage, Ph.D., Professor (Psychiatry and Behavioral Science) William (Zhiming) Suo, M.D., Research Associate Professor (Neurology)

13

Joint Appointment in Physiology (continued) Russell H. Swerdlow, M.D., Professor (Neurology) Shahid Umar, Ph.D., Associate Professor (Surgery) Darren Wallace, Ph.D., Associate Professor (Internal Medicine) Steven Warren, Ph.D., Professor (Applied Behavioral Science, KU-Lawrence;

Director, Schiefelbucsh Institute for Life Span Studies) Carl Weiner, M.D., M.B.A., Professor & Chair Associate Director (Ob-Gyn) Danny Welch, Ph.D., Professor & Chair (Cancer Biology) Alan Yu, MB, B.Chir., Professor & Director (Kidney Institute)

Adjunct Appointment in Physiology

Mark Weiss, Ph.D., Professor (Kansas State University College of Veterinary Medicine)

14

b. Graduate Students Zahraa Alali Ashley Archer (Ward) Amanda Brinker Amy Cantelina Li Chen Joshua Curry Blake Ebner Mina Farahbakhsh Cameron Fox Kelsey Hampton Wei-Ting Hung Swathi Iyer Mohammed Khan Liying Li Asona Lui John McGinnis Michelle McWilliams Danny Miller Zelha Nil Younshim Park Lei Pei Margaret Pruitt Archana Raman Robert Rogers Nairita Roy Afreen Sayed Jessica Venugopal Eric Young Chuankai Zhou

Joined Physiology

08/15 08/14 08/13 06/12 06/11 06/14 06/14

06/14 06/15 08/13 08/11 08/11 06/11 06/11 06/13 06/12 08/13 08/12 08/14 08/15 08/11 04/13 08/12 08/11 08/12 08/15 06/11 06/14 05/10

Prelims 05/16 04/15 04/14 04/13 04/12 11/15 11/15 04/14 04/13 09/12 04/12 04/12 11/14 04/13 04/14 04/13 05/15 05/16 04/13 04/15 04/13 04/13 04/13 04/12 03/14

Candidate Ph.D. Ph.D. Ph.D. M.D./Ph.D. Ph.D. M.D./Ph.D. M.D./Ph.D. M.D./Ph.D. M.D./Ph.D. M.D./Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. M.D./Ph.D. M.D./Ph.D. Ph.D. M.D./Ph.D. Ph.D. Ph.D. Ph.D. M.D./Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. M.D./Ph.D. Ph.D.

Requirements Fulfilled 05/16 12/15

05/16

12/15 12/15 Transferred Transferred

15

c. Postdoctoral Fellows Aritra Bhattacherjee, Ph.D. Pavla Brachova, Ph.D. Faezeh Koohestani, Ph.D. E. Matthew Morris, Ph.D. Colin McCoin, Ph.D. Scott Sands, Ph.D. Robert Rogers, Ph.D. Fu Chen (Jane) Yang, Ph.D.

d. Temporary Students Ganesh Aruna Cameron Banning Joseph Blond Shaon Borosha Nicholas Duethman Salman Khan Melissa Krystel-Whittemore Sierra Layton Renny Ma Adrianna Mauer Camron Myers Colton Nielson Kavya Shivashankar Bethany Snyder

16

e. Research Staff Peter Adany – Senior Research Associate Ishfaq Ahmed - Senior Scientist Julie Allen – Research Associate Janna Belousova – Senior Research Asst. Illya Bronshteyn – Research Associate Anuradha Chakrabarty – Senior Scientist Julia Draper- Research Associate Lily Gan –Research Assistant Professor Sornakala Ganeshkumar – Research Asst. Lesya Holets - Senior Scientist Naomi Holloway, Research Associate Xiaoman Hong – Senior Research Assoc. Lovella Insisienmay - Research Assistant Dora Krizsan-Agbas – Senior Scientist Zhaohui Liao – Research Associate Delin Ma, – Research Assistant Jeff McDermott – Research Associate Ying Mu – Research Associate Badal C. Roy - Senior Scientist Gladis Sanchez – Research Associate Kimberly Stanford – Research Associate Sarah Tague – Senior Scientist Mariad Thatcher – Research Associate Jonathan Warren – Resident in Dept. of Surgery Joshua Wheatley – Research Associate

f. Support Staff Liam Higgins – Accountant Katie Hoelting – Student Assistant Lynn LeCount– Managing Editor Jennifer McNichols – Editorial Coordinator Shari Standiferd – Director of Operations Jennifer Wallace – Accountant

Eric Yarns – Research Assistant Dr. Ying Zhao - Visiting Fellow

17

Activities of Graduate Students

Amanda Brinker Publications:

Reduced O-GlcNAcase Expression Promotes Mitpresotic Errors and Spindle Defects. Lanza C, Tan EP, Zhang Z, Machacek M, Brinker AE, Azuma M, Slawson C. Cell Cycle 2016 April 12:0.

Presentations:

Bringing Research to the Community: Metabolism & Cancer. 2016 Komen Kansas and Midwest Cancer Alliance Sponsored Young Investigator Event. Oral presentation and panel discussion, February 2016 Hays Kansas.

Mitochondrial polymorphisms influence metastatic efficiency in a non-cell autonomous manner. Brinker AE, Vivian CJ, Welch DR. University of Kansas Medical Center, Kansas City, KS. Oral presentation at the 17th Annual Biomedical Research Training Program Symposium, June 2016

Mitochondrial haplotype alters metastasis in a non-cell autonomous manner. Brinker AE, Vivian CJ, Welch DR. Poster presentation at the 2016

American Association for Cancer Researchers Annual Conference, April 2016 New Orleans Louisiana

Mitochondrial genomic backgrounds affect nuclear DNA methylation and gene expression. Vivian CJ, Brinker AE, Gooden GC, Legendre C, Turpin S, Koestler DC, Salhia B, and Welch DR. Poster presentation at the 2016 American Association for Cancer Researchers Annual Conference, April 2016 New Orleans Louisiana

Mitochondrial polymorphisms confer non-cell autonomous effects on cancer metastasis. Amanda E. Brinker, Carolyn J. Vivian, Danny R. Welch. Oral presentation at 2015 University of Kansas Cancer Center Research Symposium at Edwards Campus, November 2015 and poster presentation at 2015 CABTRAC meeting, October 2015 Kiawah Island South Carolina

Non-cell autonomous contributions of mitochondrial DNA to metastatic efficiency. Brinker AE, Vivian CJ, Welch DR. University of Kansas Medical Center,

Kansas City, KS. Selected oral presentation at the 2016 Heartland Center for Mitochondrial Medicine Research Symposium, May 2016

Seminars:

A Missing Piece? An exploration of mitochondria’s role in metastasis. University of Kansas Medical Center, Kansas City, KS. Oral presentation

at the 2016 Molecular & Integrative Physiology Department Seminar Series, May 2016

A role for mitochondrial polymorphisms in tumorigenesis and metastasis. Oral presentation for the 2016 Predoc Postdoc Cancer Biology Seminar, February 2016 University of Kansas Medical Center

18

Meetings Attended:

2016 Heartland Center for Mitochondrial Medicine Research Symposium, May 2016 2016 American Association for Cancer Researchers Annual Conference, April 2016 New Orleans Louisiana 2016 Komen Kansas and Midwest Cancer Alliance Sponsored Young Investigator Event, February 2016 Hays Kansas. 2015 University of Kansas Cancer Center Research Symposium at Edwards Campus, November 2015 2015 CABTRAC meeting, October 2015 Kiawah Island South Carolina

Honors/Awards:

2015 Physiology Society Travel Award, December 2015 KUCC Research Symposium Second Place Student Poster Award, November 2015 FY2016 Biomedical Research Training Program Fellowship, July 2015-July 2016

Joshua Curry Publications:

Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. The Journal of clinical investigation. 2016. doi: 10.1172/JCI83942. PubMed PMID: 27214555.

Abstracts:

Curry JN, Pei L, Evan AP, Rowe PS, Yu AS. Loss of claudin-2 leads to defective proximal tubule calcium reabsorption, hypercalciuria, and nephrocalcinosis. Poster presentation. AAP-ASCI-APSA Joint Conference, April 2016. Chicago, IL.

Presentations:

Curry JN, Pei L, Yu AS. Nephrocalcinosis develops in the renal papillae of claudin-2 knockout mice. Oral Abstract. KUMC Student Research Forum, March 2016. Kansas City, KS

Meetings Attended:

ASN Kidney Week, November 2015, San Diego, CA AAP-ASCI-APSA Joint Conference, April 2016, Chicago, IL

Honors/Awards:

APSA-ASN Outstanding Abstract, AAP-ASCI-APSA Joint 2016 National Conference

19

2nd in Oral Session, University of Kansas Medical Center (KUMC) Student Research Forum STARS Program, ASN Kidney Week 2015 National Conference ASN Kidney Tutored Research and Education for Kidney Scholars (TREKS)

Additional Accomplishments:

Supplemental Instruction Coordinator, KUMC SOM M1 Modules Facilitator, KUMC Content and Connections M2 Modules Member, Years 3-4 KUMC ACE Curriculum Committee Pathology lecturer, KUMC Step 1 Preparatory Program Vice President, KUMC MD/PhD Student Council (May 2016-present) President, Physiology Society (January-present) Activities Chair & Supplemental Instruction coordinator, MD/PhD Student Council (May 2015-May 2016)

Kelsey Hampton Publications:

Hampton, Kelsey R. (April 7th, 2016), Successfully Navigating the AACR Annual Meeting, AACR Cancer Catalyst Blog. URL: http://blog.aacr.org/successfully-navigating-aacr-annual-meeting/

Welch, Danny R., Hampton, Kelsey R. (2016, In Press) KISS1 Metastasis Suppressor. Encyclopedia of Cancer.

Presentations:

American Association for Cancer Research, Poster Presentation, New Orleans, LA, April 2016

Bringing Research to the Community: Autophagy and Cancer, Komen Kansas Affiliate and Midwest Cancer Alliance Sponsored Young Investigator Event, Oral Presentation and Discussion Panel, Hayes KS, February 2016

Cancer Biology Training Consortium, Poster Presentation, Kiawah Island, South Carolina, October 2015

Student Research Forum, 3 Minute Thesis, Kansas City, KS, March 2016 Student Research Forum, Oral Presentation, Kansas City, KS March 2016 University of Kansas Cancer Center Symposium, Poster Presentation, Overland

Park, KS, November 2015 Seminars Presented:

Metastasis Suppression by KP54 and Non-KP54 Kisspeptins, Kansas City, KS, May 2016

Meetings Attended:

American Association for Cancer Research, New Orleans, LA, April 2016 Cancer Biology Training Consortium, Kiawah Island, SC October 2015

20

Honors/Awards: First Place, 3 Minute Thesis Presentation, Student Research Forum March 2016 First Place in Oral Presentation Session, Student Research Forum March 2016 Second Place Overall in Oral Presentations, Student Research Forum March 2016 Best Oral Presentation, Women in Medicine and Science, Student Research Forum March 2016 Nominee, PEO Scholar Award, October 2015

Additional Accomplishments:

Participated in Susan G. Komen Advocacy Day with Susan G. Komen Kansas Affiliate, April 2016

Asona Lui Publications:

Lui A, New J, Ogony J, Thomas S and Lewis-Wambi, J. Everolimus downregulates estrogen receptor and induces autophagy in aromatase inhibitor-resistant breast cancer cells. BMC Cancer. 2016 Jul 16;16:487. PMCID:4947349.

Ogony J, Choi HJ, Lui A, Lewis-Wambi J. IFITM1 overexpression enhances the aggressive phenotype of inflammatory breast cancer cells in a STAT2 dependent manner. Breast Cancer Research. 2016 Feb 20;18(1):25. PMCID: 26897526.

Abstracts: Asona Lui and Joan Lewis-Wambi. Interaction between MUC1 and STAT1 drives

IFITM1 overexpression in aromatase inhibitor-resistant breast cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; Cancer Research, July 2016; 7 (14 Suppl): Abstract nr 2918.

Presentations:

KU Cancer Center Research Symposium. Poster Presenter. Kansas City, KS. Nov 13, 2015.

KU Cancer Center Cancer Biology Program Meeting, Invited Oral Presenter. Lawrence, KS. Jan 22, 2016.

Midwest Cancer Alliance/ Susan G. Komen Kansas Affiliate. Oral Presenter. Hays, KS. Feb 18, 2016.

Gordon Research Conference in Mammary Gland Biology. Poster Presenter. Barga, Italy. May 28-June 4, 2016.

Seminars Presented:

IFITM1 overexpression in aromatase inhibitor-resistant breast cancer cells. Chicago State University. Dpartment of Biological Sciences. Nov 2, 2015.

21

IFITM1 overexpression in aromatase inhibitor-resistant breast cancer. The University of Kansas Medical Center. Department of Molecular and Integrative Physiology. Jan 25, 2016.

Meetings Attended:

Lynn Sage Breast Cancer Symposium. Lurie Cancer Center. Chicago, IL. Oct 2 – Nov 1, 2016.

Honors/Awards:

2015-2016 Biomedical Research Training Program (BRTP) Fellow, The University of Kansas Medical Center F30: National Research Service Award (NRSA) National Cancer Institute (NCI) 2016 Gregg Graduate Student Achievement Award in Cancer Research, KU Endowment Carl Storm Travel Award For Minority Scholars and Physiology Society Travel Award to attend the Gordon Research Conference on Mammary Gland Biology, Barga, Italy

Michelle McWilliams Meetings Attended:

Society for the Study of Reproduction 49th Annual Meeting. Platform presentation. San Diego, CA. July 2016 2016 Kansas Capitol Graduate Research Summit, Topeka, KS. Poster presentation. KUMC Institutional Winner. Feb 2016

Honors/Awards:

Travel Award – KUMC Student Governing Council Larry Ewing Memorial Trainee Travel Fund (LEMTTF) grant – SSR Annual Conference

Danny Miller Publications:

Chen X, Suhandynata RT, Sandhu R, Rockmill B, Mohibullah N, Niu H, Liang J, Lo HC, Miller DE, Zhou H, Börner GV, Hollingsworth NM. Phosphorylation of the synaptonemal complex protein Zip1 regulates the crossover/noncrossover decision during meiosis. PLoS Biology, December 18, 2015. PMID: 26682552

Gutzwiller F, Carmo CR, Miller DE, Rice DW, Newton IL, Hawley RS, Teixeira L, Bergman CM. Dynamics of Wolbachia pipientis gene expression across the Drosophila melanogaster life cycle. G3: Genes, Genomes, Genetics, December 2015. PMID: 26497146

Miller DE, Cook KE, Yeganeh Kazemi N, Smith CB, Cockrell AJ, Hawley RS, Bergman CM. Recombination generates sequence diversity among balancer chromosomes in Drosophila melanogaster. Proceedings of the

22

National Academy of Sciences, February 2016. PMID: 26903656 Miller DE, Cook KE, Arvanitakis A, Hawley RS. Third chromosome balancer

inversions disrupt protein-coding genes and influence distal recombination events in Drosophila melanogaster. G3: Genes, Genomes, Genetics, July 2016. PMID: 27172211

Miller DE, Smith CB, Yeganeh Kazemi N, Cockrell AJ, Arvanitakis AV, Blumenstiel JP, Jaspersen SL, Hawley RS. Whole-genome analysis of individual meiotic events in Drosophila melanogaster reveals that noncrossover gene conversions are insensitive to interference and the centromere effect. Genetics, May 2016. PMID: 26944917

Abstracts:

Miller DE, Twist G, Miller NA, Bittel DC, Farrow EG, O'Brien JE, Shirali GS, Hawley RS, Kingsmore SF. Investigating the role of somatic mutation in the development of hypoplastic left heart syndrome. American Society for Human Genetics. Baltimore, MD.

Nancy M. Hollingsworth, Xiangyu Chen, Ray Suhandynata, Rima Sandhu, Beth Rockmill, Neeman Mohibullah, Hengyao Niu, Jason Liang, Hsiao-Chi Lo, Danny E. Miller, Huilin Zhou, G. Valentin Börner. Phosphorylation of the synaptonemal complex protein Zip1 by Cdc7-Dbf4 (DDK) regulates the crossover/noncrossover decision during yeast meiosis. FASEB Recombination and Genome Rearrangements meeting. Steamboat Springs, CO.

Stanley C, Miller DE, Markow T, Hawley RS, Kulathinal R. 2015. The genome of Drosophila mercatorum. Drosophila Research Conference. Chicago, IL.

Presentations:

February 2016. Genetics 101: Why rare diseases are common. Invited speaker for the Rare KC Town Hall

Seminars Presented:

March 2016. Jumping Genes: Identifying novel transposable element insertions in Drosophila melanogaster. Stowers Institute for Medical Research. Kansas City, MO.

April 2016. A genomic analysis of meiosis in Drosophila melanogaster. Stowers Institute for Medical Research. Kansas City, MO.

April 2016. The genome of the parthenogenetic fly Drosophila mercatorum. Stowers Institute for Medical Research. Kansas City, MO.

Meetings Attended: American Society for Human Genetics, Baltimore, MD Turner Syndrome Society of the US annual conference, Kansas City, MO Additional Accomplishments: Successfully defended thesis with honors

TA for Computational and Comparative Genomics at CSHL

23

Margaret Pruitt Presentations:

EMBO Conference on Telomeres, Telomerase and Disease. Poster presentation. Liege, Beligium. April 2016

Howard Hughes Medical Institute Science Meeting. Poster presentation. Ashburn, VA. June 2016

KUMC MD-PhD 10th Annual Retreat. Poster presentation. Kansas City, KS. June 2016

Honors/Awards:

Graduate Student Professional Development Award, KUMC to attend EMBO Conference on Telomeres, Telomerase and Disease. April 2016. Student Governing Council Travel Award, KUMC to attend EMBO Conference on Telomeres, Telomerase and Disease. April 2016. Ruth L. Kirschstein National Research Service Award Individual Fellowship titled, “The randomization of the telomerase RNA template to define the role of telomere sequence in telomere structure, function, and cellular survival.” Sept. 2015-present.

Archana Raman Abstracts:

Expression of Activated BRAF (V600E) in Collecting Ducts Accelerates Cyst Growth and Fibrosis in Renal Cystic Disease. Journal of American Society of Nephrology – Abstract for poster presentation in ASN conference – Nov 2016 (First author)

Periostin Overexpression in Collecting Ducts Accelerates Polycystic Kidney Disease. Journal of American Society of Nephrology – Abstract for poster presentation in ASN conference – Nov 2016 (First author)

Presentations:

American Society of Nephrology Conference - Integrin Linked Kinase Promotes Cyst Growth and Fibrosis in ADPKD – Poster presentation (First author) – San Diego, CA – Nov-2015

Meetings Attended:

American society of Nephrology – San Diego, CA – Nov- 2015 Honors/Awards:

KUMC, Graduate Professional Development Award – 2015 ASN, American Society of Nephrology Kidney STARS award – 2015

Additional Accomplishments: Summer research grant from the KU Kidney Institute, KUMC (June 2016)

24

Robert Rogers Publications:

Ma D, Shuler JM, Raider KD, Rogers RS, Wheatley JL, Geiger PC, Stanford JA. Effects of discontinuing a high-fat diet on mitochondrial proteins and 6-hydroxydopamine-induced dopamine depletion in rats. Brain Research. 2015 Jul 10;1613:49-58. doi: 10.1016/j.brainres.2015.03.053. Epub 2015 Apr 8.

Raider K, Ma D, Harris JL, Fuentes I, Rogers RS, Wheatley JL, Geiger PC, Yeh HW, Choi IY, Brooks WM, Stanford JA. A high fat diet alters metabolic and bioenergetics function in the brain: A magnetic resonance spectroscopy study. Neurochemistry International. 2016 Jul;97:172-80. doi: 10.1016/j.neuint.2016.04.008. Epub 2016 Apr 26.

Presentations:

Heat shock proteins: treating metabolic disease by turning up the heat. Ph.D. dissertation, September 1, 2015, University of Kansas Medical Center

Heat shock protein 72 regulates mitochondrial integrity and function in the prevention of hepatic insulin resistance, Rogers RS, Wheatley JL, Archer AE, Thyfault JP, Geiger PC. Poster presentation at the Experimental Biology hosted by the American Physiological Society, April 1-6, 2016

Regulation of Metabolism by Estrogen Receptor Alpha, Archer AE, Rogers RS, Wheatley JL, White KA, Rumi K, Soares MJ, Geiger PC, Poster presentation at the Experimental Biology hosted by the American Physiological Society, April 1-6, 2016

Heat shock protein 72 regulates mitochondrial integrity and function in the prevention of hepatic insulin resistance, Rogers RS, Wheatley JL, Archer AE, Thyfault JP, Geiger PC.. Poster presentation at the symposium hosted by the Heartland Center for Mitochondrial Medicine at KUMC, May 5, 2016

Regulation of Metabolism by Estrogen Receptor Alpha, Archer AE, Rogers RS, Wheatley JL, White KA, Rumi K, Soares MJ, Geiger PC, Poster presentation at the symposium hosted by the Heartland Center for Mitochondrial Medicine at KUMC, May 5, 2016

Seminars Presented:

Heat shock proteins: treating metabolic disease by turning up the heat. Ph.D. dissertation, September 1, 2015, University of Kansas Medical Center

Research in Exercise Science – Cross Roads between Basic and Applied Sciences. Rockhurst University. October 2015 and February 2016.

Meetings Attended:

Experimental Biology, American Physiological Society. San Diego, CA, April 1-6, 2016.

25

Symposium for Heartland Center for Mitochondrial Medicine, Kansas City, MO. May 5, 2016.

Additional Accomplishments:

Accepted a post-doctoral fellowship position at the University of Kansas Medical Center and will start in the Department of Anatomy and Cell Biology November 1, 2015.

Nairita Roy Publications:

Sun L, Beggs K, Borude P, Edwards G, Bhushan B, Walesky C, Roy N, Manley MW, Gunewardena S, O’Neil M, Li H, Apte U. “Bile Acids Promote Diethylnitrosamine-induced Hepatocellular Carcinoma via Increased Inflammatory Signaling.” American Journal of Physiology-Gastrointestinal and Liver Physiology. May 2016, ajpgi-00027.

Presentations:

Defended PhD successfully, November 2015 Jessica Venugopal Publications:

Jansson K, Venugopal J, Sanchez G, Magenheimer BS, Reif GA, Wallace DP, Calvet JP, Blanco G. “Ouabain regulates CFTR-mediated anion secretion and Na,K-ATPase transport in ADPKD cells.” J Membr Biol. 2015 Dec; 248(6):1145-57.

Venugopal J, Blanco G. “Ouabain enhances ADPKD cell apoptosis via the intrinsic pathway.” Front Physiol. 2016 Mar; 7:107.

Presentations:

KUMC Student Research Forum/ Podium Presentation/ Kansas City, Kansas/ March 2016

Seminars Presented:

"Ouabain-dependent calcium changes in NHK and ADPKD cells" / KUMC Kidney Institute Kansas City, KS/ May, 2016

26

27

COURSES TAUGHT

Medical Curriculum Core Courses CORE 815 – Cardiopulmonary. Dr. Geiger, Dr. Gonzalez, Dr. Smith, and Dr. Wood CORE 820 – Gastrointestinal Tract and Nutrition. Dr. LeVine CORE 825 – Renal and Endocrine System. Dr. Blanco and Dr. Wolfe CORE 830 – Reproduction and Sexuality. Dr. Albertini, Dr. Tash, and Dr. Wolfe CORE 840 – Brain and Behavior. Dr. LeVine and Dr. Stanford CORE 860 – Integration and Consolidation, Dr. Blanco, Dr. Gonzalez and Dr. Wood Departmental Graduate Courses PHSL 800 – Medical Physiology. Dr. Smith PHSL 834 – Reproductive Physiology. Dr. Chennathukuzhi PHSL 835 – Integrative Physiology of Exercise. Dr. Geiger, Dr. Gonzalez PHSL 842 – Comprehensive Human Physiology. Dr. Belousov, Dr. Blanco, Dr. Geiger, Dr. LeVine, Dr. Wolfe, Dr. Umar, Dr. Wood PHSL 844 – Neurophysiology. Dr. Cheney PHSL 846 – Advanced Neuroscience. Dr. Cheney, Dr. Enna, Dr. Lee, Dr. Smith and Dr. Stanford PHSL 851 – Seminar Course, Dr. Christenson IGPBS Courses GSMC 851 – Molecular Genetics. Dr. Chennathukuzhi, Dr. Christenson, Dr. Umar GSMC 853 – Cellular Structure. Dr. Belousov and Dr. Blanco GSMC 854 – Cell Communication. Dr. Albertini GSMC 852 – Introduction to Biomedical Research Dr. Christenson GSMC 856 – Introduction to Research Ethics. Dr. Wolfe

28

29

DEPARTMENT SEMINARS

The Department Seminar program was directed by Dr. Vargheese Chennathukuzhi. Thirty six speakers made presentations, three of which were from outside the university. In addition to support from the department, Abrahams J. Hambleton Lectureship in Physiology Endowment Fund, Kathleen M. Osborn Memorial Lectureship in Physiology Endowment Fund, the Office of the Dean of the School of Medicine, the KIDDRC, Landon Center of Aging and the Center for Reproductive Sciences made important financial contributions to our program. 08/19/15 Mohammed Khan Role of Drosophila Orb2 (CPEB) Graduate Student in synaptic protein synthesis Molecular & Integrative Physiology KUMC 09/01/15 Robert Rogers Heat shock proteins in metabolic Graduate Student disease – skeletal muscle, liver Molecular & Integrative Physiology and adipose tissue cross talk KUMC 10/05/15 Pinelopi P. Kapitsinou, M.D. PHD/HIF signaling: “Insights in Assistant Professor of Medicine vascular biology from linking Division of Nephrology & Hypertension molecular and integrative Kidney Institute physiology” KUMC 10/12/15 Nicolas Rohner, Ph.D. Hungry, fat and healthy – Assistant Investigator Cavefish as a model system for Stowers Institute for Medical Research population differences in Kansas City, MO metabolic evolution 10/26/15 William Kinsey, Ph.D. Outside-in signaling during Professor sperm-egg interactions a new Anatomy & Cell Biology role for the oocyte in sperm KUMC selection 11/02/15 Adam Krieg, Ph.D. Hypoxia, histone demethylases, Assistant Professor and ovarian cancer Institute for Reproductive Health and Regenerative Medicine KUMC

30

11/09/14 Julie Christianson, Ph.D. The role of stress in mediating Assistant Professor chronic pain and comorbid mood Anatomy & Cell Biology disorders KUMC 11/10/15 Nairita Roy Investigating the presence of Graduate Student mitochondrial DNA methylation, Molecular & Integrative Physiology its alteration and associate with KUMC mitochondrial transcription and mitochondrial function 11/16/15 Roy Jensen, M.D. Umpty-Umpth function of BRCA1 Director The University of Kansas Cancer Center KUMC 11/23/15 Mark Fisher, Ph.D. Seeing is believing: Catching and Professor reversing transient protein folds Biochemistry & Molecular Biology from native and disease states KUMC using Chaperonin-BLI platforms 11/30/15 Udayan Apte, Ph.D. HNF4alpha: Gatekeeper of Associate Professor hepatocyte quiescence Pharmacology, Toxicology & Therapeutics

KUMC 12/07/14 Kathleen M, Osborn Memorial Lectureship Dolores J. Lamb, Ph.D. Epigenetic profiling identifies Lester & Sue Smith Chair in aberrant DNA methylation- Urologic Research mediated silencing of MSH5 in Director, Center for Reproductive non-obstructive azoospermia Medicine Vice-Chairman of Research (Urology) Professor of Urology Professor of Molecular & Cellular Biology Baylor College of Medicine Houston, TX 12/14/15 Partha Kasturi Ph.D. Mitochondrial ABC transporters Associate Professor in metabolic disease: A novel for Pharmacology, Toxicology & ABCB6 in lipid homeostasis Therapeutics KUMC

31

01/11/16 Reena Rao Ph.D. Glycogen synthases kinase-3 Assistant Professor regulates renal fibroids following The Kidney Institute acute kidney injury KUMC 01/25/16 Asona Lui IFITM1 overexpression in Graduate Student aromatase inhibitor-resistant Molecular & Integrative Physiology breast cancer cells KUMC 02/01/16 Pavla Brachova, Ph.D. The effect of ovulatory follicular Post-Doctoral Fellow fluid on proliferation and DNA Molecular & Integrative Physiology damage in fallopian epithelium KUMC 02/08/16 Christy Hagan, Ph.D. Progesterone receptor action in Assistant Professor breast cancer Biochemistry & Molecular Biology

KUMC 02/15/16 Irfan Saadi, Ph.D. Genomic and genetic analyses of Assistant Professor craniofacial morphogenesis and Anatomy & Cell Biology malfunction KUMC 02/22/16 Faezeh Koohestani, Ph.D. Human uterine leiomyomas: Post-Doctoral Fellow unique regulation of WNT Molecular & Integrative Physiology pathways KUMC 02/29/16 Matthew Morris, Ph.D. Does hepatic mitochondrial Post-Doctoral Fellow function impact acute western Molecular & Integrative Physiology diet-induced weight gain?

KUMC 03/07/16 Michele Pritchard, Ph.D. Hepatic wound healing mediated Assistant Professor by the extracellular matrix Pharmacology, Toxicology & carbohydrate hyaluronan Therapeutics KUMC

03/14/16 Randal Halfmann, Ph.D. Quantitative prion biology Assistant Investigator Stowers Institute for Medical Research Kansas City, MO

32

03/21/16 Xiaogang Li, Ph.D. One epigenetic regulator Associate Professor of Medicine functions in two genetic diseases Kidney Institute KUMC 03/24/16 Swathi Iyer Roles of TMIGD3 and A3AR in Graduate Student suppression of osteosarcoma Molecular & Integrative Physiology malignancy KUMC 03/28/16 C. Ron Yu, Ph.D. Development and imprinting of a Associate Investigator sensory map in the continuous Anatomy & Cell Biology regenerating mammalian KUMC olfactory system 04/04/16 Danny E. Miller A genomic analysis of meiosis Graduate Student in drosophila melanogaster Molecular & Integrative Physiology KUMC 04/04/16 Kausik Si, Ph.D. Search for a biochemical engram Associate Investigator of memory Stowers Institute for Medical Research Kansas City, MO 04/11/16 Jennifer Gerton, Ph.D. Chromosome organizers and Investigator, Stowers Institute for cancer

Medical Research Kansas City, MO Associate Professor, Biochemistry & Molecular Biology KUMC 04/18/16 Mina Farahbakhsh Regulation of microRNA-29 by Graduate Student rest controls ADAM12 and EGF Molecular & Integrative Physiology signaling in uterine fibroids KUMC 04/25/16 Susan C. Nagel, Ph.D. Reproductive toxicity and Associate Professor endocrine disrupting activity with

Obstetrics, Gynecology and Women’s oil and gas operations Health University of Missouri School of Medicine Columbia, MO

33

05/02/16 Kelsey Hampton Metastasis suppression by Graduate Student KP54 and non-KP54 kisspeptins Molecular & Integrative Physiology KUMC 05/16/16 Voyages Seminar Series David F. Albertini, Ph.D. On matters of chance and Professor camaraderie: Why eggs reside at Molecular & Integrative Physiology the forefront of reproductive KUMC medicine 05/20/16 Exercise is Medicine Conference P. Darrell Neufer, Ph.D. Hey, mitochondriacs are people Professor too! – the science behind Department of Physiology & exercise is medicine Kinesiology East Carolina University Greenville, NC 05/23/16 Amanda Brinker The missing piece? Exploring the Graduate Student role of mitochondria in metastasis Molecular & Integrative Physiology KUMC 05/24/16 Chuankai Zhou Proteostasis in budding yeast Graduate Student Molecular & Integrative Physiology KUMC 06/09/16 Lei Pei (Pearl) Paracellular epithelial transport Graduate Student maximizes energy efficiency in Molecular & Integrative Physiology the kidney KUMC

34

35

PUBLICATIONS

a. Manuscripts Published Adany P, Choi IY, Lee P, B0-adjusted and sensitivity-enhanced spectral localization by

imaging (BASE-SLIM) in the human brain in vivo, NeuroImage (2016) 134:355-364 PMID: 27079533

Agrahari, V, Agarhari V, Hung WT, Christenson LK, Mitra. 2016. Composite Nanoformulation Therapeutics for Long-Term Ocular Delivery of Macromolecules. Mol Pharm. 2016 Feb 26 Epub ahead of Print. PMID 26828415

Arkatkar T, Gupta R, Li W, Yu JJ, Wali S, Guentzel MN, Chambers JP, Christenson, LK, Arulanandam BP. Murine MicroRNA-214 Regulates Intracellular Adhesion Molecule (ICAM-1) Gene Expression in Genital Chlamydia muridarum Infection. Immunology 2015 Aug;145(4):534-42. PMC4515133

Barrett, J. E. and Enna, S.J. Preface. Pharmacological Mechanisms and the Modulation of Pain, Advances in Pharmacology, Volume 75, pp. xi-xii, Academic Press, New York, 2016

Belousov, A.B. and J.D. Fontes, Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death. Neural Regen Res, 11(1): 75-6, 2016. PMID: 26981086

Brachova, P., Hung, WT., McGinnis, L.K., and L.K. Christenson. 2016. MicroRNA Regulation of Endocrine Functions in the Ovary. In: Post-transcriptional Mechanisms in Endocrine Regulation; Eds. K.M.J. Menon & Aaron C. Goldstrohm. Springer International Publishing, AG Switzerland.

Brauer MM, Smith PG. (2015) Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity. Autonomic Neuroscience: Basic and Clinical 187: 1-17.

Chappell I, Sturgeon DL, Lee P, McIff TE, Toby EB, Fischer KJ, Evaluation of MRI relaxation time in wrist cartilage with scapholunate ligament injury, Int J Diagnostic Imaging (2015) 2(2):96-102

Crissey JM, Padilla J, Vieira-Potter VJ, Thorne PK, Koch LG, Britton SL, Thyfault JP, Laughlin MH. Divergent role of nitric oxide in insulin-stimulated aortic vasorelaxation between low- and high-intrinsic aerobic capacity rats. Physiol Rep. 2015 Jul:3(7).

Enna, S.J. and Bylund, D.B. Diinosine Pentaphosphate, Reference Module in Biomedical Sciences, Elsevier, New York, May, 2016 doi:10.1016/B978-0-12-801238-3.09032-2

Enna, S.J. (Series Editor), James E. Barrett (Volume Editor). Pharmacological Mechanisms and the Modulation of Pain. Advances in Pharmacology, Vol. 75, Academic Press, New York, 374 pp, 2016.

Enna, S.J. (Series Editor), James P. Hardwick (Volume Editor). Cytochorome P450 Function and Pharmacological Roles in Inflammation and Cancer. Advances in Pharmacology, Vol. 74, Academic Press, New York, 473 pp, 2015.

Enna, S.J. (Series Editor), Raouf A. Khalil (Volume Editor). Endothelium. Advances in Pharmacology, Vol. 77, Academic Press, New York, 448 pp, 2016.

36

Enna, S.J. (Series Editor), Robert Schwarcz (Volume Editor). Neuropsychopharmacology: A Tribute to Joseph T. Coyle. Advances in Pharmacology, Vol. 76, Academic Press, New York, 400 pp, 2016.

Fitzgerald JB, George J, Christenson LK. 2016. Non-coding RNA in Ovarian Development and Disease. Adv Exp Med Biol. 2016; 886:79-93. PMID 26659488

Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW, Thyfault JP, Rector RS. Fibroblas growth factor 21 and exercise-induced hepatic mitochondrial adaptations. Am J Physiol Gastrointest Liver Physiol. 2016 May 15:310(10):G832-43

Fontes, J.D., J. Ramsey, J.M. Polk, A. Koop, J.V. Denisova, and A.B. Belousov, Death of neurons following injury requires conductive neuronal gap junction channels but not a specific connexin. PLOS ONE, 10(5): e0125395, 2015. PMID: 26017008, PMCID: PMC4446213

Graham A, Falcone T, Nothnick WB. (2015) The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival. Hum Reprod 30:642 – 52.

Holwerda SW, Reynolds LJ, Restaino RM, Credeur DP, Leidy HJ, Thyfault JP, Fadel PJ. The influence of reduced insulin sensitivity via short-term reductions in physical activity on cardiac baroreflex sensitivity during acute hyperglycemia.J Appl Physiol. 2015 Dec 15:119(12):1382-92.

Hung, WT, Hong X, McGinnis LK, Christenson, LK. 2015. Extracellular vesicles from bovine follicular fluid support cumulus expansion. Biol Reprod. 2015 Nov;93(5):117. PMC4712005.

Jansson, K., Venugopal, J., Sánchez, G., Magenheimer, B. S., Reif, G. A., Wallace, D. P., Calvet J. P., and Blanco G.. Ouabain regulates CFTR-mediated anion secretion and Na,K-ATPase transport in ADPKD cells (2015). Journal of Membrane Biology. 248:1145-57.

Johnson SA, Painter MS, Javurek AB, Ellersieck MR, Wiedmeyer CE, Thyfault JP, Rosenfeld CS. Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity. J Dev Orig Health Dis. 2015 Sep 18:1-14.

Kantara C., Moya SM, Houchen CW, Umar S, Ulrich RL, Singh P, Carney DH. (2015) Regenerative Peptide TP508 Mitigates Radiation-Induced Gastrointestinal Damage By Activating Stem Cells and Preserving Crypt Integrity. Laboratory Investigation.

Krystel-Whittemore M, Dileepan KN, and Wood JG. Mast cell: A multi-functional master cell. Frontiers in Immunology 6:1-12, 2016.

Kubota, K, Cui W, M.A. Dhakal P, Wolfe MW, Rumi MA, Vivian JL, Roby KF and Soares MJ. 2016. Rethinking progesterone regulation of female reproductive cyclicity. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4212-7. doi: 10.1073/pnas.1601825113. Epub 2016 Mar 28. PMID:27035990.

LeVine, SM (2016) Albumin and multiple sclerosis. BMC Neurol. 16:47. Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS. A return to

ad libitum feeding following caloric restriction promotes hepatic steatosis in

37

hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol. 2016 [epub head of print].

Linden MA, Lopez KT, Fletcher JA, Morris EM, Meers GM, Siddique S, Laughlin MH, Sowers JR, Thyfault JP, Ibdah JA, Rector RS. Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats. Apply Physiol Nutr Metab. 2015 Oct:40(10):1038-47.

Linden Ma, Sheldon RD, Meers GM, Ortinau LC, Morris EM, Booth FW, Kanaley JA, Vieira-Potter VJ, Sowers JR, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS. Aerobic exercise training in the treatment of NAFLD related fibrosis. J Physiol. 2016 Apr 22. [Epub ahead of print]

Liu TW, Heden TD, Morris EM, Fritsche KL, Vieira-Potter VJ, Thyfault JP. High-fat diet alters serum fatty acid profiles in obesity prone rats: implications for in-vitro studies. Lipids. 2015 Oct:50(10):997-1008.

Ma, D, Shuler JM, Kumar A, Tungtur S, Nishimune H, Stanford JA (2016) Tongue force training accelerates tongue motility deficits in the female SOD1-G93A rat model of Amyotrophic Lateral Sclerosis. Neurorehabil Neural Repair. [Epub ahead of print]

Marcario, J.K., Pendyala, G., Riazi, M., Fleming, K., Marquis, J., Callen, S., Lisco, S.J., Fowler, S.C., *Cheney, P.D. and *Buch, S.J. Effects of morphine on behavioral task performance in SIV-infected rhesus macaques. J. Neuroimmune Pharmacology 11: 348-257, 2016. PMID: 27039332 (*shared senior authorship)

McDermott JP, Sánchez G, Nangia A.K. and Blanco G. Role of human Na,K-ATPase alpha4 in sperm function derived from studies in transgenic mice. (2015). Mol. Reprod. Dev. 82(3):167-181.

Messamore, W.G., Van Acker, G.M. III, Zhang, H.Y., Kovac, A., Nazzaro, J.M. and Cheney, P.D. Cortical effects on ipsilateral hindlimb muscles revealed with stimulus-triggered averaging of EMG activity. Cerebral Cortex 26: 3036-3051. PMID: 26088970

Michelle M. McWilliams, Faezeh Koohestani, Wendy N. Jefferson, Sumedha Gunewardena, Riley A. Wertenberger, Carmen J. Williams, T. Rajendra Kumar, Vargheese M. Chennathukuzhi, Estrogen Receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis (communicated to JBC)

Morris EM, Meers GM, Koch LG, Britton SL, MacLean PS, Thyfault JP. Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain. Obesity. 2016 [epub ahead of print]

Morris JK, Vidoni ED, Mahnken JD, Montgomery RN, Johnson KJ, Thyfault JP, Burns JM. Cognitively impaired elderly exhibit insulin resistance and no memory improvement with infused insulin. Neurobiology of Aging. 39 (2016) 19-24.

Morris JK, Vidoni ED, Wilkins HM, Archer AE, Burns NC, Karcher RT, Graves RS, Swerdlow RH, Thyfault JP, Burns J. Impaired fasting glucose is associated with increased regional cerebral amyloid. Neurobiology of Aging. 2016 Aug:44:138-42

Munch EM, Sparks AE, Gonzalez Bosquet J, Christenson LK, Devor EJ, Van Voorhis BJ. 2016. Differentially expressed genes in preimplantation human embryos: potential candidate genes for blastocyst formation and implantation. J Assist Reprod Genet 2016; 33(8):1017-25. PMC4974233

38

Navakanitworakul R, Hung WT, Gunewardena S, Davis JS, Chotigeat W, Christenson LK. 2016. Characterization and Small RNA Content of Extracellular Vesicles in Follicular Fluid of Developing Bovine Antral Follicles. Scientific Reports 2016; 6:25486. PMC4860563

Nielson CB, Duethman, Howard JM, Moncure M, and Wood JG. Burns: Pathophysiology of systemic complications and current management. J Burn Care Res May 12, 2016 (Epub ahead of print)

Nothnick WB, Alali Z. (2016) Recent advances in the understanding and treatment of endometriosis: the role of inflammatory mediators in disease pathophysiology and treatment. F1000Research 5:186.

Nothnick WB, Al-Hendy A, Lue J. (2015) Circulating microRNAs as diagnostic biomarkers for endometriosis: privation and promise. J Minim Invasive Gynecol. 22:719 – 26.

Nothnick WB. (2015) Endometriosis: Bright future for a cloudy past? Sci Transl Med. 7:271fs.

Nothnick, WB. (2016) Non-coding RNAs in uterine development, function and disease. Adv Exp Med Biol. 886:171-186.

Nyhoff LM, Heden TD, Leidy HJ, Winn NC, Park YM, Thyfault JP, Kanaley JA. Prior exercise does not alter the incretin response to a subsequent meal in obese women. Peptides. 2015 Jul 15:71:94-99.

Padilla J, Olver TD, Thyfault JP, Fadel PJ. Role of habitual physical activity in modulating vascular actions of insulin. Exp Physiol. 2015 Jul 1:100(7):759-71.

Panasevich MR, Morris EM, Chintapalli SV, Wankhade UD, Shankar K, Britton SL, Koch LG, *Thyfault JP, *Rector RS (*co-corresponding authors). Am J Physiol Gastrointenst Liver Physiol. 2016 June [epub ahead of print]

Papineni RVL, Umar S, Brown J, Goltsov A. (2015) Stress visualization in gastrointestinal tract at different pathologies forwards a systems approach to drug repurposing. J. Bioanalysis & Biomedicine, 7(4): e129. doi:10.4172/1948-593X.1000e129.

Park YM, Kanaley JA, Padilla J, Zidon T, Welly RJ, Will MJ, Britton SL, Koch LG, Ruegsegger GN, Booth FW, Thyfault JP, Vieira-Potter VJ. Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression. Physiol Behav. 2016 [epub ahead of print]

Park YM, Kanaley JA, Zidon TM, Welly RJ, Scroggins RJ, Britton SL, Koch LG, Thyfault JP, Booth FW, Padilla J, Vieira-Potter VJ. Ovariectomized high fit rats are protected against diet induced insulin resistance. Med Sci Sports Exerc 2016 [Epub ahead of press]

Park YM, Rector RS, Thyfault JP, Zidon TM, Padilla J, Well RJ, Meers GM, Morris ME, Britton SL, Koch LG, Booth FW, Kanaley JA, Vieira-Potter VJ. Effects of ovarietomy and intrinsic aerobic capacity on tissue-specific insulin sensitivity. Am J Physiol Endocrinol Metab. 2016 Feb 1:310(3):E190-9

Pfitzinger DM, Howard JM, Moncure M, and Wood JG. Cutaneous thermal injury increases vascular permeability of rat mesenteric venules by a reactive oxidant-dependent mechanism. FASEB J 30:729.2, 2016.

Raider KD, Ma D, Harris JL, Fuentes I, Rogers RS, Wheatley JL, Geiger PC, Yeh HW, Choi I-Y, Brooks WM, Stanford JA (2016) Neurochemical differences between

39

high-fat-fed and chow-fed rats: A magnetic resonance spectroscopy study. Neurochemistry International, 97, 172-180

Raider K, Ma D, Harris JL, Fuentes I, Rogers RS, Wheatley JL, Geiger PC, Yeh HW, Choi IY, Brooks WM and Stanford JA (2016). A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resoncance spectroscopy study. Neurochem Int. Epub Apr 26. PMID: 27125544

Rao D, Kimler BF, Nothnick WB, Davis M, Fan F, Tawfik O. (2015) Transgelin: A potentially useful diagnostic marker differentially expressed in triple-negative and non-triple negative breast cancers. Hum Pathol 46:876 – 83.

Rowe PSN, Zelenchuk L, Laurence JS, Lee P, Brooks WM, and McCarthy E. Do ASARM peptides play a role in nephrogenic systemic fibrosis?, Am J Physiol – Renal Physiol (2015) 309(9):F764-9 PMID: 26336161

Sanchez, G. and Blanco, G. Na,K-ATPase alpha4: and isoform dedicated to sperm function. In Regulation of ATPases, Na+-K+-ATPase in Health and Disease” (Sajal Chakraborti and Naranjan S Dhalla Editors) “Advances in Biochemistry in Health and Disease”, Springer, New York, 2015.

Sands, SA, Tsau, S, and LeVine, SM (2015) The habenula and iron metabolism in cerebral mouse models of multiple sclerosis. Neurosci. Lett. 606:204-208. doi: 10.1016/j.neulet.2015.09.003.

Schwarcz, R. and Enna, S.J. Preface. Neuropsychopharmacology: A Tribute to Joseph T. Coyle, Advances in Pharmacology, Volume 76, pp. xvii-xx, Academic Press, New York, 2016

Sherry EB, Lee P, Choi IY, In vivo NMR studies of the brain with metabolic disorders, Neurochem Res (2015) 40(12):2647-85, PMID: 26610379

Stevens JR, Kearney ML, St-Onge MP, Stanhope KL, Havel PJ, Kanaley JA, Thyfault JP, Weiss EP, Butler AA. Obesity. 2016 Aug;24(8):1731-40.

Sureban SM, May R, Qu D, Chandrakesan P, Weygant N, Ali N, Lightfoot SA, Ding K, Umar S, Schlosser MJ, Houchen CW. (2015) Dietary pectin increases intestinal crypt stem cell survival following radiation injury. PLoS One

Syeda SS, Rice R, Hook DJ, Heckert LL and Georg GI (2016) Synthesis Arylazide- and Diazirine-containing CrAsH-EDT2 Photoaffinity Probes. Arch Pharm (Weinheim). Apr;349(4):233-41.

Szary N, Rector RS, Uptergrove GM, Ridenhour SE, Shukla SD, Thyfault JP, Koch LG, Britton SL, Ibdah JA. High intrinsic aerobic capacity protects against ethanol induced hepatic liver injury and metabolic dysfunction: study using high capacity runner rat model. Biomolecules. 2015 Nov 20:5(4):3295-308.

Tabanor K, Lee P, Kiptoo P, Choi IY, Sherry E, Williams TD, Siahaan TJ, Brain delivery of drug and MRI contrast agent: detection and quantitative determination of brain deposition of CPT-Glu using LC-MS/MS and Gd-DTPA using magnetic resonance imaging, Mol Pharm (2016) 13:379-390, PMID: 26705088

Tatiana Karpova, Kumarasamy Ravichandiran, Lovella Insisienmay, Daren Rice, Valentine Agbor and Leslie L. Heckert (2015) Steroidogenic factor 1 differentially regulates fetal and adult Leydig cell development in male mice. Biology of Reproduction. Oct;93(4):83

Thyfault JP, Morris EM. Intrinsic (genetic) aerobic fitness impacts susceptibility for metabolic disease. Exerc Sport Sci Rev. 2016 Jul 18.

40

Todebusch RG, Ruegsegger GN, Braselton JF, Heese AJ, Hofheins J, Childs TE, Thyfault JP, Booth FW. AMPK-agonist AICAR delays the initial decline in lifetime-apex VO2peak while voluntary wheel running fails to delay its initial decline in female rats. Physiol Genomics. 2016 Feb:48(2):101-15.

Valencia AP, Schappal AE, Matthew Morris E, Thyfault JP, Lowe DA, Spangenburg EE. The presence of the ovary prevents hepatic mitochondrial oxidative stress in young and aged female mice through glutathione peroxidase 1. Exp Gerontology. 2016 Jan:73:14-22.

Van Acker, G.M., Griffin, D.M. and Cheney, P.D. Timing of cortico-muscle transmission during active movement. Cerebral Cortex 26: 3335-3344, 2016. PMID: 26209849

Venugopal A, Subramaniam D, Balmaceda J, Roy B, Dixon D, Umar S, Weir S, Anant

S. (2015) RNA binding protein RBM3 increases -catenin signaling to increase stem cell characteristics in colorectal cancer cells. Molecular Carcinogenesis Aug 31. doi: 10.1002/mc.22404. [Epub ahead of print] PMID: 26331352.

Venugopal, J. and Blanco, G. Ouabain Enhances ADPKD Cell Apoptosis via the Intrinsic Pathway (2016). Front Physiol. 24:100-107.

Wang WT, Lee P, Kim J, Dong Y, Weiner CP, Brooks WM, Choi IY, In vivo neurochemical characterization of developing guinea pigs and the effect of chronic fetal hypoxia, Neurochem Res (2016) 41(7):1831-43 PMID: 27233245

Wilkins HM, Koppel SJ, Weidling IW, Roy N, Ryan L, Stanford JA, Swerdlow RH (2016) Extracellular mitochondria and mitochondrial components act as damage-associated molecular pattern molecules in the mouse brain. J Neuroimmune Pharmacol. [Epub ahead of print]

Yang, Q., Gong, M., Cai, S., Zhang, T., Douglas, J.T., Chikan, V., Davies, N.M., Lee, P., Choi, I.-Y., Ren, S., & Forrest, M. L. “Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast.” Therapeutic Delivery (2015) 6(10):1195-210 PMID: 26606855, PMCID: PMC4702516

Yao L, Li Y, Knapp J, Smith P. (2015) Exploration of molecular pathways mediating electric field-directed Schwann cell migration by RNA-seq. J Cell Physiol:1515-24

41

b. Manuscripts in Press Belousov, A.B., J.D. Fontes, M. Freitas-Andrade, and C.C. Naus, Gap junctions and

hemichannels: communicating cell death in neurodevelopment and disease. BMC Cell Biology, in press, 2016

Choi IY, Lee P, Hughes AJ, Denney DR, Lynch SG, Longitudinal changes of cerebral glutathione (GSH) levels associated with the clinical course of disease progression in patients with secondary progressive multiple sclerosis, Multi Scler (in press)

Enna, S.J. and McCarson, K.E. Targeting the GABAB Receptor for the Treatment of Pain. In: GABA B Receptors (G. Colombo, ed.), Springer, Berlin, in press.

Gupta R *, Arkatkar T *, Keck J, Kaundinya GKL, Castillo K, Hobel S, Chambers JP, Yu JJ, Guentzel MN, Aigner A, Christenson LK, Arulanandam, BP. Antigen Specific Immune Response in Chlamydia muridarum Genital Infection is Dependent on Murine MicroRNAs-155 and -182. In Press Oncotarget

Hamilton DJ, Minze LJ, Kumar T, Cao T, Lyon CJ, Geiger PC, Hsueh WA, Gupte AA (2016). Estrogen receptor alpha activation reverses mitochondrial function and energy imbalance in high fat-fed ovariectomized mice. In Press, Physiol Reports, Sep;4(17). PMID: 27582063

Rogers RS, Morris EM, Wilson DR, Archer AE, White KS, Wheatley JL, Meers GME, Koch LG, Britton SL, Thyfault JP, Geiger PC (2016). Deficiency in the heat stress response could underlie susceptibility to metabolic disease. In Press, Diabetes Aug 23 Epub ahead of print. PMID:27554472

Sands, SA and LeVine, SM (2016) Substrate reduction therapy for Krabbe’s disease. J. Neurosci. Res. In press.

Subramanian A, Gupta V, Sarkar S, Maity G, Banerjee S, Ghosh A, Harris L, Christenson LK, Hung W, Bansal A, Banerjee SK. Exosomes in carcinogenesis: molecular palkis carry signals for the regulation of cancer progression and metastasis. J Cell Commun. Signal. 2016 Jul 29 In Press.

42

c. Abstracts

Adany P, Choi IY, Denney D, Hughes A, Belliston S, Lynch S, Lee P, Region-based structural MRI measures offer better specificity in correlation with cognitive performance in patients with secondary progressive multiple sclerosis, Multiple Sclerosis Journal 2015; 21(S11):648, 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Barcelona, Spain, October 07-10 (2015) P1239 – poster presentation

Adany P, Choi IY, Lee P, 1H MRS of gray and white matter in the human brain using B0 Adjusted Sensitivity Encoded Spectral Localization by Imaging (BASE-SLIM), Proc Int Soc Magn Reson Med 24, 6742, Singapore, Singapore, May 7 – 13 (2016) – electronic multimedia poster presentation

Ahmed I, McLaughlin S, Goltsov, A, Umar S, Papineni RV. (2015) Radiation related gastrointestinal injuries differ during different stress conditions in mouse. 61st Annual Meeting, September 19-22, Weston, FL.

Bansal, A., J., Mathur, S., Rastogi, A., Sharma, P., and Christenson, L.K. 2016. Multiple Inflammatory Cytokines Cause a Barrett's Esophagus Like Metaplastic Change via FOXF1 (2437404), Digestive Disease Week® (DDW) at the San Diego Convention Center in San Diego, CA, May 21-24, 2016.

Blanco G. Na,K-ATPase α4 isoform as a target for male contraception. American Society of Andrology Meeting, Salt Lake City, 2015.

Brachova P, Munch E, Santillan D, Van Voorhis B, and LK Christenson. 2015. The effect of human ovulatory follicular fluid on fallopian epithelial cell proliferation and DNA damage accumulation. 48th Anuual Meeting of Society for the Study of Reproduction.

Choi IY, Lee P, Adany P, Hughes A, Denney D, Lynch S, Cerebral antioxidant glutathione (GSH) in major subtypes of multiple sclerosis: Relations with MRI measures and clinical status, Multiple Sclerosis Journal 2015; 21(S11):641, 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Barcelona, Spain, October 07-10 (2015) P1226 – poster presentation

Choi CY, Thomas NJ, Ronca-Finco AE, Christenson LK, Tash JS, Alwood JS. Are changes in sex-hormone receptors in bone associated with altered bone remodeling during simulated weightlessness? In: 31st Annual Meeting of the American Society for Gravitational and Space Research. Alexandria, VA; 2015.

Faezeh Koohestani, Michelle McWilliams, Wendy Jefferson, Kavya Shivashankar, Carmen Williams & Vargheese Chennathukuzhi. WNT/PCP Pathways in the Pathogenesis of Uterine Fibroids. Best Poster Award Recipient: 48th Annual Meeting of Society for the Study of Reproduction, 18–22 June 2015 San Juan, Puerto Rico, USA

Holets-Bondar LM, Knapp J, Tash JS. BION-M1: Space flight for 30d alters the testis morphology and spermatogenic important genes expression in male mice. In: American Society for Graviational and Space Research. Alexandria, VA; 2015.

Hung WT, McGinnis LK, and LK. Christenson. 2015. Follicular Fluid Extracellular Vesicles (EVs) Regulate Cumulus-Oocyte-Complex (COC) Expansion and Gene

43

Expression in Cumulus Cells. 48th Anuual Meeting of Society for the Study of Reproduction

J. Vivian, S. Tague, D. Agbas, J. Draper, J. Pace, S. Paul, M. Weiss, P. Smith. 2015. Differentiated human pluripotent stem cells for cell-based therapy of spinal cord injury. Society for Neuroscience Annual Meeting, Chicago IL.

Kubota, Kaiyu, Wei Cui, M.A. Karim Rumi, Pramod Dhakal, Michael W. Wolfe, Jay L. Vivian, Katherine F. Roby and Michael J. Soares. 2015. Hormonal regulation of female reproductive cyclicity: a role for progesterone? 12th Annual Gilbert S. Greenwald Symposium on Reproduction, Kansas City, KS.

Kubota, Kaiyu, Wei Cui, M.A.K. Rumi, Pramod Dhakal, Michael W. Wolfe, Jay L. Vivian, Katherine F. Roby and Michael J. Soares. 2015. Hormonal regulation of female reproductive cyclicity: a role for progesterone? 48th Annual Meeting of the Society for the Study of Reproduction, San Juan, Puerto Rico.

Larson MA, Bronshteyn I, Vivian CJ, Welch DR, Vivian JL (2016) Nuclear Transfer between Strains of Inbred Mice. Trans Res 16(2):203-204.

Lee CY, Bennett KM, Debbins JP, Choi IY, Lee P, Relations between the stretched exponential DWI model and tumor malignancy related microstructural changes, Proc Int Soc Magn Reson Med 24, 1269, Singapore, Singapore, May 7 – 13 (2016) – electronic multimedia poster presentation

Lee CY, Choi IY, Adany P, Lee P, Prospective frequency correction for TE-averaged semi-LASER, Proc Int Soc Magn Reson Med 24, 6338, Singapore, Singapore, May 7 – 13 (2016) – poster presentation

Lee P, Adany P, Choi IY, Regional analysis of diffusion MRI (DKI/DTI) in patients with multiple sclerosis: Correlation with cognitive function and clinical measures, Proc Int Soc Magn Reson Med 24, 6225, Singapore, Singapore, May 7 – 13 (2016) – poster presentation

Lee P, Adany P, Denney D, Hughes A, Lynch S, Choi IY, Regional and tissue-type based assessment of Gaussian and non-Gaussian diffusion MRI indices in three subtypes of multiple sclerosis using diffusional kurtosis imaging, Multiple Sclerosis Journal 2015; 21(S11):497, 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Barcelona, Spain, October 07-10 (2015) P978 – poster presentation

Ma D, Harris JL, Snyder B, Brooks WM, Shapiro SM, Stanford JA (2016) Cerebellar anatomical and neurochemical dysfunction with hyperbilirubinemia in 21-day-old and 4-month-old Gunn rats. Poster presented at the 23rd Annual Meeting of the American Society for Neural Therapy and Repair in Clearwater Beach, FL.

Ma D, Shuler JM, Kumar A, Tungur S, Nishimune H, Stanford JA (2015) Tongue strength training accelerates tongue motility deficits in the SOD1-G93A rat model of Amyotrophic Lateral Sclerosis. Poster presented at the 26th International Symposium on ALS/MND in Orlando, FL.

McDermott J and Blanco G. Na,K-ATPase α4 is essential to preserve sperm flagellar morphology. Society for the Study of Reproduction. San Diego, June 2016.

McDermott J and Blanco G. Na,K-ATPase α4 maintains sperm osmotic balance and morphology. Gordon Conference. Fertilization and Activation of Development. Holderness, NH, July 2015.

44

Michelle McWilliams, Faezeh Koohestani, Sornakala Ganeshkumar, Carmen Williams, Sumedha Gunewardena, T. Rajendra Kumar, Vargheese Chennathukuzhi. “ER-alpha and EZH2 Regulate REST-dependent Epigenetic Modifications Through PRICKLE1 in Uterine Leiomyoma”. Platform Presentation, 49th Annual Meeting of Society for the Study of Reproduction, 16–20 July 2016, San Diego, CA

Mina Farahbakhsh, Faezeh Koohestani and Vargheese Chennathukuzhi. The Role of REST Target Genes in the Pathogenesis of Uterine Leiomyomas. 48th Annual Meeting of Society for the Study of Reproduction, 18–22 June 2015. San Juan, Puerto Rico, USA

Mina Farahbakhsh, Faezeh Koohestani, Vargheese Chennathukuzhi “Regulation of MicroRNA-29 by REST Controls ADAM12 and EGF Signaling in Uterine Fibroids”. Platform Presentation, 49th Annual Meeting of Society for the Study of Reproduction, 16–20 July 2016, San Diego, CA

Nishimune H, Tungur S, Stanford JA, Tanaka T, Nadeau LL (2015) Active zone degeneration causes neuromuscular junction denervation in ALS model rodents. Poster presented at the 45th Annual Meeting of the Society for Neuroscience in Chicago, Il.

Pohler KG, Green JA, Moley LA, Hung WT, Hong X, Christenson LK, Geary TW, and MF Smith. 2015. Circulating exosomal derived microRNAs as a biomarker of embryonic viability in cattle, 48th Anuual Meeting of Society for the Study of Reproduction

Rumi, Mohammad, Katherine Roby, Xiao Zhao, Khursheed Iqbal, Anamike Ratri, Rafia Mir, Shaon Borosha, Tianhua Lei, Wei Cui, Kaiyu Kubota, Pramod Dhakal, Michael Wolfe, Jay Vivan and Michael Soares. 2015. Defining roles for ESR2 in the regulation of female fertility. 12th Annual Gilbert S. Greenwald Symposium on Reproduction, Kansas City, KS.

S.E. Tague, M. K. Winter, N. Sanlı, C.E. Lunte, K.E. McCarson, P.G. Smith. 2015. Dietary vitamin B6 differentially modulates cutaneous sensitivity, peripheral sensory axon morphology and spinal cord neurotransmitter content in diabetic and non-diabetic mice. Society for Neuroscience Annual Meeting, Chicago IL.

Shameem Sultana Syeda, Gladis Sanchez, Kwon Ho Hong, Gunda Georg and Gustavo Blanco. Male contraception via inhibition of the testis-specific Na,K-ATPase α4 isoform. Washington State University, Pullman, WA. October 2015.

Tash JS, Okwuazi E, Yarns EM. Suitability of human and bovine sperm for in vitro reproductive biology studies on the ISS. In: American Society for Gravitational and Space Research. Alexandria, VA; 2015.

Wilkins HM, Roy M, Stanford JA, Swerdlow RH (2015) Injecting Mitochondria into Mouse Hippocampi Induces Neuroinflammation and Raises APP Expression. Poster presented at the Alzheimer’s Association International Conference in Washington, D.C.

45

RESEARCH SUPPORT

A.B. Belousov: KUMC, LIED award- “Do gap junctions play a role in neuronal death or neuronal survival?” June 7, 2016 - June 30, 2017. Annual Direct Costs: $10,000 V.G. Blanco: NIH – “Inhibitors of Na, K-ATPase alpha4 as male contraceptives.” 2014 – 2019. Annual Direct Costs: $230,000. NIH – Kansas IDeA network of biomedical Research Excellence. 2014-2019. IRHRM – “Follicular fluid exosomes and microvesicles impact on sperm function.” 2014-2015. Annual Direct Costs: $10,000. V.M. Chennathukuzhi: KU Endowment Startup funds – 2009-current. NIH/NICHD – “Dissecting the functional role of miRNAs in decidualization. ” Principal Investigator: W. Nothnick, Co-Investigator: VM Chennathukuzhi. 2013 – 2015. Annual Direct Costs: $125,000. NIH/NICHD – “The role of REST in the pathogenesis of uterine fibroids” July 2013 – June 2018. Principal Investigator: V.M. Chennathukuzhi. Annual Direct Costs: $238,042. NIH/NICHD – “Inhibitors of Na,K-ATPase alpha4 as male contraveptives.” 2014-2019. Annual Direct Costs: $182,000. L.K. Christenson: KU Cancer Center – “Exosomes and their non-coding RNA profiles in Barrett’s Esophagus. January 9, 2014 – December 30, 2015. Principal Investigator: A. Bansal, Co-Investigator: L.K. Christenson. $35,000. NASA – “Female reproductive health: Space flight induced ovarian and estrogen signaling dysfunction, adaptation, and recovery.” November 1, 2014 – October 31, 2017. Annual Direct Costs: $178,678. NICHD – “Exosome/ microvesicle regulation of oocyte development competence.” December 15, 2014 – November 30, 2016. Annual Direct Costs: $150,000. KINBRE – “MicroRNA Based Nanotherapeutics for Barrett’s Neoplasia.” May 1, 2015 – april 30, 2016. Annual Direct Costs: $50,000. Lalor Foundation – “The role of CD81 in follicular exosome function.” June 1, 2015 – May 31, 2016. Principal Investigator: . Annual Direct Costs: $50,000. COBRE – “Molecular Regulation of Cell Development and Differentiation.” September 1, 2012 – June 30, 2017.

46

S.J. Enna: Elsevier – Editorial Office: Biochemical Pharmacology and Pharmacology and Therapeutics. 2004 – 2019. Annual Direct Costs: $140,000. International Union of Basic and Clinical Pharmacology – Society Office. 2006-2018. $52,000. NICHHD – “Kansas University Training Program in Neurological and Rehabilitiation.” Principal Investigator: R.J. Nudo. Associate Director: S.J. Enna. May 2014 – April 2019. Annual Direct Costs: $266,000. P.C. Geiger: KUMC Research Institute- “Targeting estrogen receptor alpha in the prevention of insulin resistance and type 2 diabetes.” August 1, 2015- August 31, 2015 KUMC Research Institute- “HSP72 and mitochondrial function in hepatic lipid metabolism and insulin resistance.” March 3, 2016- March 2, 2017 L.L. Heckert: Marion M. Osborn Endowment NIH – “Molecular Regulation of Cell Development and Differentiation.” September 1, 2012- June 30, 2017. Principal Investigator: D. Abrahamson. Co-Investigators: G. Andrews and M. Soares. Co-Director of Core B: L.L. Heckert. Direct costs: $1,453,124. RI – “In vivo Function of a 3’ Distal Regulatory Element of Fshr.” February 3, 2015 – February 29, 2016. Annual Direct Costs: $20,000. RI – “Travel award to NA Testis Workshop.” April 2015. $2,800. M.A. Larson: Institutional Development Award (IDeA), National Center for Research Resources, NIH – “Molecular regulation of cell development and differentiation.” September 1, 2012 – June 30, 2017. Principal Investigator: D. Abrahamson Core B – “Transgenic Facility.” Principal Investigator: M.A. Larson. Total direct costs for entire project period: $617,085. Kansas-Idea Network of Biomedical Research Excellence (K-INBRE) LabStamp Tattoo Systems for Mouse Identification Services May 1, 2016 – April 30, 2017. Principal Investigator: M.A. Larson. Direct costs for equipment: $7999 S.M. LeVine: ApoPharma Inc. – Extension for “Iron Chelation in Experimental Autoimmune Encephalomyelitis” July 2015 – June 2017. Annual Direct Costs: $80,000. Parron Trust Research Grants/Kansas City Area Life Sciences Institute – “AAV Gene Therapy for Krabbe Disease” August 2015 – July 2016. Annual Direct Costs: $41,667 W.B. Nothnick: NIH – “The role of miR-451 in endometriosis pathophysiology” March 2012 – January 2017. Annual direct costs $303,000.

47

NIH – “The role of REST in the pathogenesis of uterine fibroids.” August 2013 – April 2018. Annual Direct Costs: $230,804. P.G. Smith:NIH – “Identifying therapeutic targets for vulvodynia.” July 1, 2012 – June 30, 2017. Principal Investigator: P. Smith. Annual Direct Cost: $260,000. NIH – Institutional Clinical and Translational Science Award. June 1, 2011 – February 29, 2016. Annual Direct Costs: $260,000 NIH – “Creation and characterization of models of a BLHLB9 developmental disorder.” June 1, 2015 – May 31, 2017. Annual Direct Costs: $135,000 NIH– Kansas Intellectual & Developmental Disabilities Research Center (KIDDRC). September 26, 2011 – June 30, 2016. Annual Direct Costs: $410,000 Kansas University Endowment Association – “Spinal Cord Injury Repair Program.” April 15, 2011 – April 14, 2018. Annual Direct Costs: $400,000 Merck, Sharpe & Dohme – “Effect of Known and Novel AT2 Compounds on Axon Growth and Skin Innervation.” December 17, 2014 – December 16, 2015. Annual Direct Costs: $110,000 J.A. Stanford: CMH Research Agreement Children’s Mercy Hospital – “Preclinical studies of bilirubin encephalopathy.” June 1, 2013 – May 31, 2017. Contract Principal Investigator: J.A. Stanford. Annual Direct Costs: $100,000. NIH – “Exercise-activated mechanisms reduce degeneration of aged neuromuscular junctions .” September 30, 2015 – May, 31 2020. Total Costs: $1,959,385 J.S. Tash: NIH – “H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents.” September 01, 2012 – June 31, 2017. NIH – “Cell-cycle regulatory kinases as targets for male contraceptive drug development.” April 1, 2014 – March 31, 2019. NASA – “Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents.” August 1, 2013 – October 31, 2016. NASA – “Female reproductive health: Space flight induced ovarian & estrogen signaling dysfunction, adaptation, and recovery.” November 1,2014 – October 31, 2017. Burroughs Wellcome Fund – “Effects of novel non-hormonal male contraceptive agents on ovarian function.” May 20, 2015 – May 19, 2016

48

J. Thyfault: NIH– “Aerobic fitness, mitochondrial dysfunction, and fatty liver disease.” April 1, 2011 – March 31, 2016. Principal Investigator: J. Thyfault. Direct costs: No Cost Ext. $40,000 Veteran Affairs Merit Review – “Mitochondrial mitophagy in the development and treatment of NAFLD.” October 1, 2014 – September 31, 2018. Principal Investigator: J. Thyfault. Annual Direct Costs: $222,000 KUMC – “Metabolomics Signmatures that Occure in Alzheimer’s Disease (AD) Patients with and without type 2 Diabetes in Comparison to Controls (non-AD) with or without type 2 Diabetes.” November 1, 2015 – October 31, 2016. Annual Direct Costs: $35,334 S. Umar: NCI – “Epigenetics and Infection-induced EMT of Colonic Crypts- Target for Chemoprevention.” December 1, 2014 – November 30, 2019. Annual Direct Costs: $263,084. NCI – “Bitter Melon Component and Colon Cancer Prevention.” September 1, 2014 –August 31, 2019. Annual Direct Costs: $360,735. M.W. Wolfe: NIH – “Stem cells and epigenetics of trophoblast lineage development.” July 2014 – June 2019. Annual Direct Costs: $733,408. J.G. Wood: NIH – “Teacher and Students for Community – Oriented Research and Education (T-SCORE) PI: Paula Cupertino, PhD. February 1, 2016 – January 30, 2020. Annual Direct Costs: $200,000.

49

ACTIVITIES OF FACULTY

Andrei B. Belousov, Ph.D., Associate Professor We are interested in the mechanisms of regulation of neuronal gap junctions (electrical synapses) during development and neuronal injury. We also study the role of neuronal gap junctions in death of neurons in the developing nervous system and in the secondary, glutamate-dependent neuronal death following ischemic stroke, traumatic brain injury and epilepsy. As a result of these studies, a novel model of the mechanisms of glutamate-dependent neuronal death has been proposed, where neuronal gap junctions play a critical role.

Committee Activities: Member, Greater Kansas City Chapter of the SFN KUMC Physiology Department Representative, KUMC Faculty Council Editorial and Grant Reviews: Ad hoc Reviewer, Neuroscience Letters Ad hoc Reviewer, African Journal of Biotechnology Ad hoc Reviewer, Neural Regeneration Research Ad hoc Reviewer, Neuropharmacology Ad hoc Reviewer, Translational Neuroscience Ad hoc Reviewer, The Open Neuroscience Journal Editorial Board Member, the Open Neuroscience Journal (ON), Bentham

Science Publishers Teaching Activities: PHSL 842 – Comprehensive Human Physiology 9 – 2 hour lectures GSMC 853 – Cellular Structure

2 – 2 hour lectures 1 – 2 hour seminar T32 Summer Journal Club 1 – 2 hour lecture Research Personnel: Janna V. Belousova, Senior Research Assistant

50

V. Gustavo Blanco, M.D., Ph.D., Professor & Interim Chair Our laboratory studies the role of ion-transport proteins of the plasma membrane in

cell function. Research is focused on the Na, K-ATPase, a plasma membrane enzyme

system that uses the energy from ATP to establish and maintain the high internal K+

and low internal Na+ concentrations characteristic of most animal cells. Specific

research projects include:

1). Mechanism of function, regulation and role of the testes-specific isoform of the

Na,K-ATPase (Na,K-ATPase α4) in sperm function and male fertility. We discovered

Na,K-ATPase α4, characterized its expression and determined its function as

essential for sperm motility and male fertility. Because of the importance of α4 in

sperm physiology, we are pursuing experiments directed to utilize Na,K-ATPase α4 as

a marker for male fertility; and as a target for male contraception. We are trying to

develop specific inhibitors of the Na,K-ATPase α4 that can block sperm motility for

their use in male contraception. Overall, this project is important to understand sperm

physiology, male fertility and contraception.

2). Role of the Na,K-ATPase in autosomal dominant polycystic kidney disease

(ADPKD). In this project, we are investigating the role of the Na,K-ATPase in cyst

generation and progression in ADPKD kidneys. We have found that in ADPKD, the

Na,K-ATPase exhibits an abnormally increased sensitivity to ouabain, a hormone

released by the adrenal glands. We discovered ouabain as a circulating factor that

promotes ADPKD cystic phenotype. We are currently studying the intracellular

pathways involved in ouabain effects and the mechanisms of action of ouabain in

ADPKD cells, with the idea to use this information to pharmacologically interfere with

the pro-cystogenic actions of ouabain to treat ADPKD.

Meetings Attended:

December 2015 – Association of Chairs of Departments of Physiology. St. Thomas, US Virgin Islands.

July 2015 - Gordon Conference. Fertilization and Activation of Development. Holderness, NH.

October 2015 - UO1/U54 Steering Committee on Reproduction. Washington State University, Pullman, WA.

April 2016 - American Society of Andrology. New Orleans. Committee Activities: Departmental Member, Kidney Institute Executive Board Member, Allocation Model for distribution of funds within the department Member, Comprehensive Exam Committee for graduate students Student Service Committee Mentor, Wescoe Society, Internal Medicine

51

Dr. Blanco (continued)

Member, Thesis Committee, Wei-Ting Hung, Physiology, Ph.D Member, Thesis Committee, Michelle Mcwilliams , Physiology, Ph.D Member, Thesis Committee, Zahraa Alali, Physiology, Ph.D Member, Thesis Committee, Archana Raman, Internal Medicine, Ph.D

Member, Thesis Committee, Pei-Lei, Internal Medicine, Ph.D Member, Thesis Committee, Wen Zhao, Pharmacology, Ph.D Member, Thesis Committee, Kelli Boxberger, Pharmacology, Ph.D Member, Thesis Committee, Yuchen Zhang, Pharmacology, Ph.D Member, Thesis Committee, Carina Henriksen, Aarhus University,

Denmark, Ph.D Member, Thesis Committee, Karl Weigand, Raboud University Nijmegen,

The Netherlands, Ph.D Member, Thesis Committee, Younshim Park, Physiology, Ph.D

KUMC

Director, Developmental Research Project Core of the K-INBRE. Member, MD/Ph.D. Admission Committee Program, including interviewing

students Member, University Biotechnology Sequencing Facility Member, Organization of the Greenwald Symposium Editorial and Grant Reviews:

Editorial Board Member, American Journal of Physiology Editorial Board Member, Journal of Assisted Reproduction and Genetics

Reviewer, American Journal of Physiology Reviewer, Journal of Assisted Reproduction and Genetics Reviewer, National Institute of Aging, NIH Board of Scientific Counselors,

Baltimore, MD Charter Member, NIH CMIR Study Section

Invited Presentations: October 2015 – “Male contraception via inhibition of the testis-specific Na,K-ATPase α4 isoform.” Washington State University, Pullman, WA. Seminars Presented:

2015 – “Na,K-ATPase α4 isoform as a target for male contraception.”

American Society of Andrology Meeting, Salt Lake City.

May, 2016 – “Ouabain-dependent calcium changes in NHK and ADPKD

cells.” Kidney Institute, KUMC

Academic Honors: Students Voice Award for Excellence in Teaching (2014-2015), University of

Kansas Medical Center

52

Dr. Blanco (continued) Teaching Activities: Renal Physiology, CORE 825 – Renal Endocrine System, Medical Physiology 14 hours lecture 2 hours review for renal physiology for Board preparation 4 hours small group facilitation

Integration and Consolidation CORE 860 – Renal Physiology for Medical Students 1 hour Lecture

Renal Physiology. Board review, Step Prep 1 contact hour.

Renal Summer Rediation 6 hour session IGPBS 853 – Cell membrane structure and transport systems of the plasma membrane. 6 hours lecture.

Comprehensive Human Physiology, PHSL 842 – Graduate student course. 8 contact hours.

Pre-Med college students from KU 1 contact hour.

Advanced course in ion transport – Radbound University Medical Center, Nijmegen, The Netherlands

6 hours Frontiers in Reproduction – Marine Biological Laboratories, Woods Hole, MA KINBRE 6 hours each semester Rotating Lab Students 2 Students Research personnel

Gladis Sanchez, Research Associate. Project title: Na,K-ATPase alpha4 as a target for male contraception.

Jeff McDermott, Research Associate. Project title: Molecular Physiology of Na,K-ATPase alpha4.

Jessica Venugopal, Graduate Student. Project title: Ouabain-Mediated Enhancement of the dedifferentiated phenotype of Autosomal Dominant Polycystic Kidney Disease Cells.

53

Paul D. Cheney, Ph.D., Professor

Neurophysiological techniques are used to investigate the functional contribution of neurons in the cerebral cortex and brainstem to the control of voluntary movement. The spike (action potential) activity of single neurons is recorded in awake monkeys trained to perform various movement tasks. Computerized analysis techniques are used to reveal the functional contribution of a neuron or localized groups of neurons to movement. In another project, SIV infection in monkeys is used as model of neuro-AIDS. This model is used to investigate interactions between SIV infection and drugs of abuse using neurobehavioral, neurophysiological, and neuroanatomical methods. Committee Activities: Departmental Comprehensive Exam Committees: Lying Li Dissertation Committee, mentor for Kausik Si School of Medicine

Member, Internal Advisory Committee, NIH Neuroscience Rehabilitation Training Grant, Dr. Nudo, PI.

KUMC Member, Institute for Neurological Disorders Executive Committee

KUMC-KU Lawrence Member, KIDDRC Internal Scientific Advisory Committee

Editorials and Grant Reviews: Ad hoc Reviewer, J. Neurophysiology Ad hoc Reviewer, J. Neuroscience

Ad hoc Reviewer, Cerebral Cortex Ad hoc Reviewer, Brain Stimulation

Grant Reviewer, Neurological & Rehabilitation Sciences T32 training grant applications, Dr. Nudo, PI

Grant Reviewer, KUMC Biomedical Research Training Program Grant Reviewer, KUMC Woodyard Fellowship Applications, Institute for Neurological Disorders

Teaching Activities:

PHSL 844- Neurophysiology Fall 2015, 10 students 15 lecture hours PHSL 846 – Advanced Neuroscience

Summer 2015, 3 students 6 lecture hours ME 751-Mechanical Engineering, Biomechanics (Dr. Carl Luchies-Director) Fall 2015, 32 students 2 hours lecture

54

Vargheese M. Chennathukuzhi, Ph.D., Associate Professor My research interests include uterine fibroids, fertility and contraception. Uterine fibroids are the most common tumors of the female reproductive tract and are the leading indication for hysterectomies in the US. Sadly, there is no approved drug to treat uterine fibroids chronically. Our laboratory is trying to understand the regulation and function of GPR10, a G protein-coupled receptor, aberrantly expressed in uterine fibroids. We have generated transgenic mice overexpressing GPR10 in the myometrium in order to understand its role in the pathogenesis of fibroids. Transgenic-hGPR10 mice develop uterine fibroids that are phenotypically identical to the human disease. We plan to use this preclinical model for the development of small molecule modulators of GPR10 as treatment for fibroids. In addition, we have identified the molecular machinery that regulates aberrant expression of GPR10 in uterine fibroids. We recently developed a conditional knockout model for Rest, the transcriptional repressor of GPR10. Rest cKO mice are infertile and develop uterine fibroid phenotype. We have also identified PRICKLE1 as the upstream regulator of REST stability and function in the uterus. Our laboratory is trying to validate the role of environmental estrogens in the suppression of Prickle1 gene and REST protein expression using rodent models. Our laboratory is also interested in molecules that regulate sperm function and male fertility. We are studying functional regulation of the sperm specific sodium-proton exchanger (sNHE) in expression systems that utilize chimeric channels. Committee Activities: Departmental Member, Finance Committee Member, GSAC Coordinator, Physiology Seminar Series Member, Graduate Student Oral Comprehensive Exams Student Service Committee Member, Thesis Committee, Zahraa Alali, Physiology, Ph.D Member, Thesis Committee, Younshim Park, Physiology, Ph.D

Member, Thesis Committee, Sara Pearson. Anatomy and Cell Biology, Ph.D

Member, Thesis Committee, Wei-Ting Hung, Physiology, Ph.D Member, Thesis Committee, Saieed Safder, Microbiology, Ph.D Member, Thesis Committee, Ashley Ward, Physiology, Ph.D KUMC Member, Faculty Council Member, D3ET (Drug Discovery, Delivery and Experimental

Therapeutics), IAMI

55

Dr. Chennathukuzhi (continued) Editorial and Grant Reviews: Reviewer, Human Reproduction Reviewer, Molecular Reproduction and Development Reviewer, Developmental Biology Reviewer, Science Advances

Reviewer, Biology of Reproduction Member, Cellular Molecular and Integrative Reproduction Member, Special Emphasis Panel/Scientific Review Group 2016 ZRG1 EMNR-D (02) M

Member, Special Emphasis Panel/Scientific Review Group RFA-HD-16-003, RFA-HD-16-004

Teaching Activities: PHSL 834 – Reproductive Physiology Course Director

IGPBS 851 – Genetic Switches-Gene Expression 3-2 hour sessions

Research personnel:

Faezeh Koohestani, Ph.D. (Postdoctoral Fellow): The Role of REST in the pathogenesis of uterine fibroids

Michelle McWilliams (Graduate Student): Estrogenic regulation of PRICKLE1 and its effect on REST in uterine fibroids

Mina Farahbakhsh (M.D./Ph.D. Graduate Student): Role of ADAM12 and other REST target genes in uterine fibroids

Sornakala Ganeshkumar (Research Assistant) Kavya Shivashankar (Summer Intern, June – Aug 2016, Undergraduate Student,

Columbia, NY. Ganesh Aruna (Summer Intern, June – Aug 2015, High School Senior):

Regulation of PRICKLE1 in Alzheimer’s disease

56

Lane K. Christenson, Ph.D., Associate Professor Fertility, infertility and ovarian cancer are major health concerns for women. Research in my laboratory focuses on understanding the terminal events involved in follicular development and ovulation. The studies have direct implications in development of a fertile healthy oocyte, contraception and disease conditions such as polycystic ovarian syndrome and ovarian cancer. Current studies focus on understanding the role extracellular vesicles (exosomes and microvesicles) play in ovarian function (oocyte maturation, granulosa cell function) and in ovarian cancer. The laboratory is also examining how post-transcriptional regulatory processes such as RNA editing impacts oocyte developmental competence. These studies use the latest state of the art technologies, including next-gen-sequencing, nanoparticle analysis in addition to standard molecular and biochemical techniques. The laboratory also uses a comparative approach using human, bovine and murine cells and animal studies in both cows and mice to gain further insights into the reproductive biology of the ovary. Committee Activities: Departmental Member, Departmental Finance Committee Student Service Committee

Member, Advisory Dissertation, Jennifer Crow, Pathology, Ph.D. Member, Advisory Dissertation, Li Chen, Physiology, Ph.D. Member, Advisory Dissertation, Zahraa Alali, Physiology, Ph.D.

Member, Advisory Dissertation, Greg Burns, Animal Science, Ph.D. University of Missouri

KUMC Member, Advisory Committee for the Microarray Facility Member, Mass Spectrometry Oversight Committee

National Director on SSR Board, Society for Study of Reproduction Program Committee Co-Program Chair, 2016 SSR Meeting Faculty/Lecturer, Frontiers in Reproduction Course at Marine Biol. Laboratory

Editorial and Grant Reviews:

Ad hoc Reviewer, Cell and Tissue Research Ad hoc Reviewer, Endocrinology Ad hoc Reviewer, Reproduction Ad hoc Reviewer, Plos Genetics Ad hoc Reviewer, Plos One Ad hoc Reviewer, Mutation Research Reviews

57

Dr. Christenson (continued) Editorials and Grant Review (continued)

Ad hoc Reviewer, Steroids Ad hoc Reviewer, Biology of Reproduction Ad hoc Reviewer, Molecular and Cellular Endocrinology Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer, Molecular Human Reproduction Ad hoc Reviewer, Journal of Ovarian Research Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer, Board of Reviewing Editors for Biology of Reproduction Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer: National Institute of Health-P50 Project Reviewer, Feb. 29 –

March 2, Bethesda, MD 2016 Reviewer, National Institute of Health- Reproduction, Andrology and Gynecology

Study Section 2015-19 – Permanent member Seminars Presented:

October 7, 2015 – “Functional Roles for Exosomes and Microvesicles in Ovarian Follicles.” Department of Animal Science, University of Missouri, Columbia, MO

Teaching Activities: GSMC 851 - Molecular Genetics (IGPBS) 2-2 hour lectures GSMC 852-Introduction to Biomedical Research (IGPBS)

1-2 hour lecture PHSL 851-Seminar

6-1 hour lectures Student Contact Undergraduate, graduate, and medical student mentoring Meetings Attended:

July 2015 - 48th Annual Meeting of Society for the Study of Reproduction, San Juan, Puerto Rico October 2015 - American Society for Gravitational and Space Research, Washington DC

Research personnel:

Wei-Ting Hung – Ph.D. Advisor: Extracellular Vesicles in Ovarian Antral Follicles: Characterization and Functions

Pavla Brachova – Postdoctoral Fellow: Role of follicular fluid exosomes on induction of ovarian/fallopian carcinogenesis.

Xiaoman Hong- Senior Research Associate

58

Salvatore J. Enna, Ph.D., Professor, Associate Dean for Research and Graduate Education Research interest is focused on neurotransmitters and neurotransmitter receptors, with particular emphasis on the structure, function and pharmacology of GABA receptors. Meetings Attended: July 2015 - Summer School of Neuroscience, University of Catania, Catania, Italy

August 2015 – Nebraska INBRE Meeting, Lincoln, Nebraska September 2015 – Brazilian Society of Pharmacology Meeting, Aguas de

Lindoia, Brazil October 2015 – International Union of Basic and Clinical Pharmacology

Nomenclature Meeting, Paris, France October, 2015 - Italian Society of Pharmacology Meeting, Naples, Italy November 2015 - Biochemical Pharmacology Editorial Board Meeting, Miami,

Florida November 2015 - Current Protocols in Pharmacology Editorial Board Meeting,

Philadelphia, Pennsylvania December 2015 - British Pharmacology Society Meeting, London, UK March 2016 - Training in Neurotherapeutics Discovery and Development for

Academic Scientists Meeting, Bethesda, Maryland April 2016 - International Union of Basic and Clinical Pharmacology

Nomenclature Meeting, Edinburgh, UK Committee Activities:

Departmental Chair, Departmental Appointments, Promotions, and Tenure Committee

KUMC Internal Advisory Committee, Kansas University Training Program in

Neurological and Rehabilitation Sciences Member, Research and Training Committee Member, Faculty Activity Collaborative Tool (FACT) Committee

Member, Medical School Extended Dean’s Committee National Chair, Nebraska-BRIN External Advisory Committee Member, PhRMA Foundation Pharmacology Advisory Panel

President, International Union of Basic and Clinical Pharmacology (IUPHAR)

Member, Research Advisory Council, University of Missouri-Kansas City School of Pharmacy

Member, GABA-B Nomenclature Database Committee Member, UMKC School of Pharmacy Research Advisory Council

GABA-B Nomenclature Database Committee

59

Dr. Enna (continued)

International International Union of Basic and Clinical Pharmacology (IUPHAR)

Executive Committee

Editorials and Grant Reviews: PhRMA Foundation Pharmacology/Toxicology Grant Review Committee

Grant Reviewer, Centre de Recherche Clinique, University of Geneva, Geneva, Switzerland

Editorial Boards of Scientific Journals: Editor-in-Chief, Biochemical Pharmacology

Executive Editor-in-Chief, Pharmacology & Therapeutics Co-Editor, xPharm Co-Editor-in-Chief, Current Protocols in Pharmacology Series Editor, Advances in Pharmacology Guest Editor, Biological and Pharmaceutical Bulletin Section Head, Neuropharmacology and Psychopharmacology, Faculty of 1000 Pharmacology Section Editor, Reference Module in Biomedical Sciences

Editorials and Grant Review (continued)

Editorial Advisory Board Memberships: Brain Research Life Sciences CNS Drug Review Current Opinion in Pharmacology Chinese Medicine Pharmacology International

Ad hoc Reviewer, Journal Manuscripts Brain Research

Life Sciences Ad hoc Reviewer, Journal of Pharmacology and Experimental Therapeutics

Invited Presentations:

July 2015 - “GABA Receptors and Cognition: Perspectives for Drug Development”, Summer School of Neuroscience, University of Catania, Catania, Italy

September 2015 - “An Alternative Approach to Lead Generation”, Brazilian Society of Pharmacology and Experimental Therapeutics Annual Meeting, Aguas de Lindoia, Brazil

October 2015 - “Keynote Lecture”, Italian Society of Pharmacology Meeting, Naples, Italy

March, 2016 - “Alternative Approaches to Lead Generation”, Training in Neurotherapeutics Discovery and Development for Academic Scientists, Bethesda, Maryland

60

Dr. Enna (continued) Seminars Presented:

November, 2015 “Challenges in CNS Drug Discovery: Reductionism Versus Empiricism”, Inaugural Douglas S. Riggs Lecture in Pharmacology, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York

April, 2016 “Drug Discovery: Alternative Approaches to Lead Generation”, University of Perugia, Perugia, Italy

April, 2016 “Guidelines for Manuscript Preparation”, University of Perugia, Perugia, Italy

April, 2016 “Drug Discovery: Alternative Approaches to Lead Generation”, University of Bologna, Bologna, Italy

April, 2016 “Guidelines for Manuscript Preparation”, University of Bologna, Bologna, Italy

Teaching Activities: Faculty Advisor Orr Society Mentor for:

Nathan Marshall Andrew Kwan Ojas Patel 6 – 1 hour Group Sessions

T32 Summer Student Journal Club 10 – 1 hour Group Sessions

Medical Education Cardiopulmonary Module 2 -2 hour group sessions Graduate School of Pharmacy (Lawrence Campus) 1 – 2 hour Session Psychiatry Residents Lecture 1 – 2 hours Session PHSL 846 Advanced Neuroscience 4 - 2 hour lectures Associates Ms. Lynn LeCount, Managing Editor, Biochemical Pharmacology; Pharmacology

& Therapeutics; Pharmacology International, and Advances in Pharmacology

Ms. Jennifer McNichols, Editorial Coordinator, Biochemical Pharmacology; Pharmacology & Therapeutics, Pharmacology International, and Advanced in Pharmacology

Dr. Ying Zhao, Visiting Fellow, Chinese Pharmacology Society, Beijing, China.

61

Dr. Enna (continued) Other Activities: Scientific Consultant, Orion Corporation, Orion Pharma, Turku, Finland Academic Honors:

Douglas S. Riggs Lectureship in Pharmacology Award, Department of Pharmacology, University of Buffalo, Buffalo, New York

Elected Honorary Fellow of the British Pharmacological Society, December 2015

62

Paige C. Geiger, Ph.D., Associate Professor Diabetes affects 23.6 million Americans (7.8% of the population); and by 2030, the global numbers are projected to increase above 400 million. A progressive decline in the body's ability to detect and respond to stress could result in the development and/or acceleration of a number of metabolic disease states, including insulin resistance and obesity. Heat shock proteins (HSPs) are best known as molecular chaperones, but they also play key anti-inflammatory and cell signaling roles. Patients with type 2 diabetes demonstrate reduced expression of heat shock protein 72 (HSP72) and a blunted exercise-induced heat stress response. Previous studies from our laboratory and others demonstrate that the induction of HSPs via heat treatment, transgenic overexpression, or pharmacological agents is protective against high fat diet-induced skeletal muscle insulin resistance. Planned studies should provide compelling new information about the relationship between heat shock proteins, aerobic capacity and metabolic function. As a result, new strategies could be developed to modulate HSP-dependent pathways as a therapeutic approach to treat insulin resistance. Meetings Attended:

April 2-5 2016 – Experimental Biology. San Diego, California August 29-31 2016 – Physiology. Dublin, Ireland Wambach K, Siengsukon C, Befort C, Fazzino T, Evans T, Thornton K, Geiger PC.

A Childcare Needs Assessment at an Academic Medical Center. Abstract and Poster Presentation at the Midwest Nursing Research Society 2016.

Invited Presentations:

“Exercise and Type 1 Diabetes,” Juvenile Diabetes Research Foundation TypeOneNation Summit, Cerner Riverport Landing, February 6, 2016.

“Obesity, insulin resistance and diabetes: Sex differences and the role of estrogen receptors.” Mayo Clinic Young Investigators Research Symposium. March 18-19, 2016.

Symposium Chair, Physiology 2016, a joint meeting of the American Physiological Society and The Physiological Society. “Mitochondria in the Integrative Physiology of Obesity and Metabolic Dysfunction. Dublin, Ireland July 29-31, 2016.

Committee Activities: Departmental Member, Graduate Student Affairs Committee Member, Narita Roy Ph.D. dissertation committee Member, Asona Lui MD/Ph.D. dissertation committee

63

Dr. Geiger (continued)

KUMC Co-organizer, Exercise is Medicine Regional Conference at KUMC

Member, A Healthy U, Physical Activity Workgroup Member, KUMC Childcare Center Task Force Member, Exercise is Medicine Student Group Faculty Advisor

Member, American Medical Women’s Association Faculty Advisor Board Member, Cray Diabetes Center Advisory Board Member, KUMC Student Union Corporation Board Member, School of Health Professions Dean Search Committee, School of Medicine Representative Member, School of Medicine McCann Professor of Women in Medicine and Science Selection Committee Member, Orr Society Faculty Advisor

Community Member, Rosedale Neighborhood Development Association Healthy Halloween Event

Editorials and Grant Reviews:

Ad hoc Reviewer, American Journal of Physiology Endocrinology and Metabolism Ad hoc Reviewer, Metabolism Ad hoc Reviewer, Molecular and Cellular Endocrinology Ad hoc Reviewer, Medicine and Science in Sports and Exercise

Ad hoc Reviewer, Diabetes Ad hoc Reviewer, Applied Physiology Ad hoc Reviewer, NIH Integrative Physiology of Obesity (IPOD) Study Section Ad hoc Reviewer, NIH National Institute of Aging, Special Emphasis Panel Ad hoc Reviewer, PLOS One

Editorial Board Reviewer, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

Teaching Activities: PHSL 842 – Comprehensive Human Physiology 11 – 3 hour lectures

CORE 815 – Cardiopulmonary Module, M1 Students 4 hours lecture 4 hour small group 4 hour evaluator for case study presentations PHSL 835 - Integrative Physiology of Exercise 64-7 hour lectures

64

Dr. Geiger (continued) Additional Student Contact: Ashely (Ward) Archer – Graduate Fellowship Awardee Camron Myers – Summer Scholar and volunteer Joseph Blond – Volunteer Research Personnel: Joshua Wheatley, MS – Research Associate

Robert Rogers, MA, PhD –Dissertation Defense Oct. 1, 2015 Ashley Archer – PhD Candidate

65

Sumedha Gunewardena, Ph.D., Research Assistant Professor

Research Interest: Bioinformatics and computational genomics: modeling protein-DNA interactions, biological sequence analysis, microarray data analysis, biological pathways and network analysis, development of computational tools and databases. Publications:

Navakanitworakul R, Hung WT, Gunewardena S, Davis JS, Chotigeat W, Christenson LK. ``Characterization and Small RNA Content of Extracellular Vesicles in Follicular Fluid of Developing Bovine Antral Follicles''. Sci Rep. 2016 May 9;6:25486. doi: 10.1038/srep25486. PubMed PMID: 27158133; PubMed Central PMCID: PMC4860563.

Sun L, Beggs K, Borude P, Edwards G, Bhushan B, Walesky C, Roy N, Manley MW Jr,

{\bf Gunewardena S}, O'Neil M, Li H, Apte U. ``Bile acids promote"diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling''. Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G91-G104. doi: 10.1152/ajpgi.00027.2015. Epub 2016 May 5. PubMed PMID: 27151938.

Beggs KM, McGreal SR, McCarthy A, Gunewardena S, Lampe JN, Lau C, Apte U.

``The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction''. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29. doi: 10.1016/j.taap.2016.05.001. Epub 2016 May 3. PubMed PMID: 27153767.

Gunewardena SS, Yoo B, Peng L, Lu H, Zhong X, Klaassen CD, Cui JY. ``Deciphering

the Developmental Dynamics of the Mouse Liver Transcriptome''. PLoS One. 2015 Oct 23;10(10):e0141220. doi: 10.1371/journal.pone.0141220. eCollection 2015.

Sharma N, Nanta R, Sharma J, Gunewardena S, Singh KP, Shankar S, Srivastava RK.

``PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth''. Oncotarget. 2015 Oct 13;6(31):32039-60. doi: 10.18632/oncotarget.5055.

Gunewardena S, Walesky C, Apte U. ``Global Gene Expression Changes in Liver

Following Hepatocyte Nuclear Factor 4 alpha deletion in Adult Mice''. Genom Data. 2015 Sep 1;5:126-128.

66

Leslie L. Heckert, Ph.D., Marion M. Osborn Professor for Reproductive Sciences Research interests have consistently focused on the transcriptional and cell-signaling processes for proper function and development of the gonads, with the goal of extending our mechanistic understanding of the biology of fertility, in hopes to facilitate clinical improvements for contraceptive options and diagnosis and treatment of infertility. More recently, I have developed a significant interest in establishing a collaborative program with Dr. Jill Jacobson, M.D. at Children’s Mercy Hospital. The intent is to develop a program that integrates both clinical and basic research to improve our understanding of the mechanisms underlying disorders of sex development and gender dysphoria. Meetings Attended: October 22-23, 2015 - Greenwald Symposium, Kansas City Public Library

April 2-5, 2016 - 41ST Annual Conference of the American Society of Andrology, Astor Crowne Plaza, New Orleans, LA

Committee Activities: Departmental Member, Department Finance Committee Member, Promotions & Tenure Committee KUMC Member, Institutional Biosafety Committee

Member, Transgenic and Gene Targeting Core Oversight Committee Member, IGPBS Curriculum Committee Member, IGPBS Oversight Committee Reviewer, Inter-Institutional Pilot Grant Program

National

Member, Future Meetings Committee, Society for the Study of Reproduction

Chair, Program Committee, XXIV North American Testis Workshop Editorial and Grant Reviews:

Reviewer, Inter-Institutional Pilot Grant Program Ad hoc reviewer

Agence Nationale de la Recherche Biology of Reproduction Endocrine Molecular and Cellular Biology PNAS

Editorial Board Member, Endocrinology

67

Dr. Heckert (continued) Assistant:

Lovella Insisienmay; Research Assistant (part time). A distal 3’ element regulates gonadotropin signaling.

Activities:

Course Review for the Marine Biological Laboratory’s “Frontiers in Reproduction”.

68

Melissa A. Larson, Ph.D. Research Assistant Professor As the Technical Director of the Transgenic and Gene-Targeting Institutional Facility, my role is largely defined by service. I am responsible for providing services in the generation of gene-modified mice, sperm and embryo cryopreservation, assisted reproductive technologies, and embryonic stem cell propagation and targeting. We provide these services for investigators at KU Med and KU-Lawrence, as well as the entire Kansas City metro area. In addition, I am interested in exploring and implementing new technologies that allow creation of unique mouse research models. Presentations:

March 20-23, 2016 - Oral presentation at the 13th Transgenic Technology Meeting, “Nuclear Transfer between Strains of Inbred Mice”, Prague, Czech Republic.

October 13, 2015 - Presented an international webinar for the American Association for Laboratory Animal Science on “Rescue Strategies for Lines of Genetically Engineered Mice”.

Meetings Attended:

March 20-23, 2016 - 13th Transgenic Technology Meeting, Prague, Czech Republic.

November 1-4, 2015 - Representative for the International Society for Transgenic Technologies, booth display presentation, American Association for Laboratory Animal Science National Meeting, Phoenix, AZ.

Committee Activities: KUMC Member, Institutional Animal Care and Use Committee Member, Programmatic Sub-Committee of the Institutional Animal Care

Use Committee Member, Institutional BioSafety Committee National Representative, American Association for Laboratory Animal Science on

behalf of the International Society for Transgenic Technologies Seminars Presented:

Center for Reproductive Sciences Journal Club presentation, August 14, 2015, “Making Transgenic and Gene-Targeted Mice – and Other Fun Stuff We Can Do!”

Additional Activities

Contracted by Springer to edit a volume, The Transgenic Mouse, to be published early 2017 Developing text for the American Association for Laboratory Animal Science (AALAS) Online Learning Library, courses on Colony Management and Transgenic Technology.

69

Dr. Larson (continued) Research personnel:

Illya Bronshteyn, MS, Research Associate Julia Draper, MS, Research Associate

Honors/Awards:

International Society for Transgenic Technologies Registration Award to 13th Transgenic Technology Meeting, March 20-23, 2016, Prague, Czech Republic.

International Society for Transgenic Technologies Travel Award to 13th Transgenic Technology Meeting, March 20-23, 2016, Prague, Czech Republic.

70

Phil Lee, Ph.D., Associate Professor

The major focus of my research is to characterize structural, functional, physiological changes linked to disease activity and progression using advanced in vivo magnetic resonance imaging techniques. Another important focus of my research is to develop novel in vivo neuroimaging techniques to offer new possibilities for monitoring the disease status and the impact of treatments through new quantitative, non-invasive biomarkers. My own research and collaboration have yielded 8 publications during this fiscal year. Invited Presentations:

October 27, 2015 – Faculty Research Day Participation, KUMC Research Institute, Kansas City, KS

Choi IY, Lee P, Statland J, McVey AL, Dimachkie MM, Brooks WM, Barohn RJ, Reduction in cerebral antioxidant, glutathione (GSH), in patients with ALS: A preliminary study, 2015 Faculty Research Day and Poster Session

P, Choi IY, Denney D, Hughes A, Belliston S, Lynch S, Lee P, Region-based structural MRI measures offer better specificity in correlation with cognitive performance in patients with secondary progressive multiple sclerosis, 2015 Faculty Research Day and Poster Session

Lee P, Adany P, Denney D, Hughes A, Lynch S, Choi IY, Regional and tissue-type based assessment of Gaussian and non-Gaussian diffusion MRI indices in three subtypes of multiple sclerosis using diffusional kurtosis imaging, 2015 Faculty Research Day and Poster Session

Seminars Presented:

July 24, 2015 - Gray matter changes in white matter disease: Imaging microstructure changes in multiple sclerosis brain, Neurology / Neurosurgery Grand Rounds / KUMC

Meetings Attended:

October 07-10, 2015 - The 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Barcelona, Spain

May 7 – 13, 2016 - The 24th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine (ISMRM), Singapore, Singapore

Committee Activities: KUMC Director, MR Technology at the Hoglund Brain Imaging Center

71

Dr. Lee (continued) Editorials and Grant Reviews: Ad hoc Reviewer, Frontiers in Neurology

Ad hoc Reviewer, International Journal of Molecular Sciences

Ad hoc Reviewer, Journal of Magnetic Resonance Imaging

Ad hoc Reviewer, Magnetic Resonance Materials in Physics, Biology and Medicine

Ad hoc Reviewer, Metabolic Brain Disease

Ad hoc Reviewer, Neurochemical Research

Ad hoc Reviewer, NMR in Biomedicine

Grant Reviewer, KU Cancer Center Pilot

Teaching Activities: PHSL 846/ANAT 846 – Advanced Neuroscience 1 - 2 hour lecture 9.4T MRI New Users Workshop discussion 1 hour - Monthly Neuroimaging Study Group 2 hours - Weekly Advisor:

Graduate Students: Sean Ellis, Andrea Freemyer Service on Student Committees: Sean Ellis, Bioengineering, Thesis committee Andrea Freemyer, Otolaryngology, Thesis committee Other Activities:

Consultant of MR program of Center for Brain, Biology and Behavior at University of Nebraska

Research Personnel: Chu-Yu Lee, postdoc at Hoglund Brain Imaging Center

Peter Adany, Senior research associate at Hoglund Brain Imaging Center Sean Ellis, Graduate student of Bioengineering program, KU-L Mariad Thatcher, Research associate at Hoglund Brain Imaging Center

72

Steven M. LeVine, Ph.D., Professor We study two demyelinating diseases of the central nervous system, multiple sclerosis and Krabbe’s disease. We examine pathogenic mechanisms and test experimental interventions in animal models of these diseases. The goal of our studies is to improve treatment options for patients afflicted with these conditions. Committee Activities: Departmental Member, Graduate Student Advisory Committee Member, Departmental Promotions and Tenure Committee

Student Service Committee Member, Thesis committee, Co-Chair of Thesis Defense, Mohammed Khan, Physiology, Ph. D.

KUMC Member, Safety Committee for the Smith East Building Editorials and Grant Reviews:

Ad hoc Reviewer, Journal of Neuroscience Research Ad hoc Reviewer, Neuroimmunology Ad hoc Reviewer, Neurochemistry

Teaching Activities: CORE 820 – Gastrointestinal Tract and Nutrition 5 – 1 hour Lectures CORE 840 – Brain, Mind and Behavior 4 - 1 hour Group Sessions PHSL 842 – Comprehensive Human Physiology 4 – 1 hour Sessions Research Personnel: Scott Sands, Ph.D. – Post-Doctoral fellow Other Activities:

Member, Multiple Sclerosis Research Group, KUMC

Director, PHSL 843 Physiology of Disease, which was approved by the Graduate Council and organized by Dr. Levine

Director, Molecular Mechanisms of Neurological Disorders (PHSL 848; NEUS

848; NURO 848; ANAT 848). Course is offered every other year, offered Fall 2016.

73

Warren B. Nothnick, PhD, HCLD, Professor Endometriosis is a disease common in women of reproductive age characterized by pain and infertility. Despite its high prevalence, those factors which contribute to the development and progression of the disease remain unknown. The focus of my research is to examine the role of microRNAs, small RNAs which post-transcriptionally regulate gene expression, in the pathogenesis of the disease as well as examine their utility as prognostic markers and therapeutic targets. Committee Activities: Departmental Member, Department of Molecular & Integrative Physiology, University of

Kansas Medical Center, Departmental Promotion and Tenure Committee, 2014 – present

Chairman, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Finance Committee

Student Committee Service: Member, Wei-Ting Hung, Physiology, Ph.D Member, Michelle Mcwilliams , Physiology, Ph.D Member, Amanda Brinker, Physiology, Ph.D Member, Mina Farahbakhshs, Physiology, Ph.D Chairman, Zahraa Alali, Physiology, Ph.D

KUMC Member, Institute for Reproductive Health and Regenerative Medicine

Space/Operating Committee Member, The Gilbert S. Greenwald Reproductive Biology Symposium

planning committee Judge, Poster Presentation Competition, The 12th Annual Gilbert S.

Greenwald Symposium on Reproduction Panelist, Dual Careers Across the Academic Continuum, Women in

Medicine and Science, University of Kansas Medical Center Member, Appointment, Promotion and Tenure Committee, School of

Medicine, University of Kansas Medical Center Member, IRHRM Seminar Program Committee, University of Kansas

Medical Center Member, IRHRM End User/Supply Center Committee, University of

Kansas Medical Center Participant, University of Kansas Medical Center/University of Kansas

Hospital, Faculty Leadership Academy Member, Strategic planning committee, Center for Reproductive Sciences,

University of Kansas Medical Center Scientific Director, Laboratory Animal Resources; University of Kansas

Medical Center

74

Dr. Nothnick (continued)

Chairman, Laboratory Animal Resources Advisory Committee for the University of Kansas Medical Center

Member, Advisory Committee for the University of Kansas Medical Center Institutional Official

Invited Presentations:

March 15, 2016 - “Endocytotic receptors and the endometrium/endometriosis.” 63rd Annual Meeting for the Society for Reproductive Investigation, Endometrium Satellite Symposium, Montreal, Canada.

Editorial and Grant Reviews: Ad hoc Reviewer, American Journal of Obstetrics and Gynecology

Ad hoc Reviewer, Biology of Reproduction Ad hoc Reviewer, Endocrinology Ad hoc Reviewer, Human Reproduction Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer, Journal of Clinical Endocrinology and Metabolism Ad hoc Reviewer, Molecular Human Reproduction Ad hoc Reviewer, PLoS ONE Ad hoc Reviewer, Proceedings of the National Academy of Sciences (PNAS) Ad hoc Reviewer, Reproduction Ad hoc Reviewer, Reproductive Sciences Ad hoc Reviewer, Science-Translational Medicine Ad hoc Reviewer, Scientific Reports (Nature Publishing Group) Ad hoc Reviewer, Department of Veterans Affairs, Cellular and Molecular

Medicine (CAMM) review panel, Washington DC, May 23, 2016 (phone reviewer)

Ad hoc Reviewer, Society for Reproductive Investigation, Early Career Research Grant Program, 2015 – 2016.

Ad hoc Reviewer, The Research Foundation – Flanders (FWO; Belgium), August/September, 2015.

Ad hoc Reviewer Panel, the 49th Annual Meeting for the Society for the Study of Reproduction, 2016.

Member, Abstract Review Committee, American Society for Reproductive Medicine, Endometriosis Special Interest Group, 72nd Annual Meeting of the American Society for Reproductive Medicine, 2016.

Standing Member, NIH/EMNR Initial Review Group, Integrative and Clinical Endocrinology and Reproduction Study Section (ICER)

Vice-Chair, NIH/EMNR Initial Review Group, Integrative and Clinical Endocrinology and Reproduction Study Section (ICER)

75

Dr. Nothnick (continued) Teaching and Academic Service:

Thread leader, Endocrine and Gastrointestinal Physiology. Active, Competency-based, and Excellence-driven (ACE) Medical Student curriculum (0.2 FTE/year).

Honors/Awards:

Ambassador, World Endometriosis Society Visiting Professor Pro Tempore, Cleveland Clinic Educational Institute, 2015 Human Reproduction – Best Reviewer 2015 (acknowledged as a top 10%

reviewer for the journal based upon quality and promptness of manuscript reviews).

76

Peter G. Smith, Ph.D., Professor Director of the Institute for Neurological Discoveries, Co-Director of the Kansas Intellectual and Developmental Disabilities Research Center, Senior Associate Dean for Research My research interests include: i) Mechanisms of peripheral nervous system plasticity leading to sensory nerve sprouting in increased mechanical sensitivity; ii) Role of the peripheral sensory nervous system in abnormal sensitivity in Rett syndrome and related Autism Spectrum Disorders; iii) Repair of the damaged nervous system using stem cell-derived neuronal precursors; iv) Creation and characterization of cellular and organismal models of genetic neurodevelopmental disorders. Meetings Attended:

September 10-12, 2015: AAMC GRAND Meeting. Baltimore, MD September 26-28, 2015: International Society for Autonomic Neuroscience,

Stresa, Italy September 28-October 1, 2015. Neuropeptides 2015 conference in Aberdeen,

Scotland. October 17-20, 2015: Society for Neuroscience, Chicago IL. November 11-13, 2015: Intellectual and Developmental Disabilities Research

Centers Directors’ meeting, Sacramento CA. Invited Presentations:

November 2, 2015. Consequences of a GEMIN5 mutation on nervous system development, Undiagnosed Disease Gene Function, National Genome Research Institute, 11/2/15

September 28, 2015 - "Angiotensin II as a trophic factor mediating sensory axon sprouting and hypersensitivity in inflammatory pain". Neuropeptides 2015 conference in Aberdeen, Scotland.

Committee Activities: KUMC

Senior Associate Dean for Research Chair, Research Advisory Council Chair, Research Institute Research Committee Chair, Executive Committee, Institute for Neurological Discoveries Chair, Woodyard Fellowship in Neurodegenerative Disorders Selection Committee Director, Spinal Cord Injury Repair Program Director, Frontiers Pilots and Collaborative Research Projects program, CTSA Member, Anesthesiology Chair Search Committee Chair, KUMC Genomics Core Advisory Committee Member, Mass Spectroscopy Advisory Board Affiliate Member, KU Cancer Center

77

Dr. Smith (continued)

Member, Alzheimer’s Disease Center Internal Advisory Board, and Executive Committee

National North American Representative to the Executive Committee of the International Society for Autonomic Neuroscience (ISAN)

Editorials and Grant Reviews: Ad hoc Reviewer, Journal of pain Ad hoc Reviewer, Journal of Physiology (Lond.)

Ad hoc Reviewer, PLOSOne Ad hoc Reviewer, Molecular & Cellular Endocrinology Ad hoc Reviewer, Autonomic Neuroscience

Reviewer, Undiagnosed Disease Network Guest Editor, Autonomic Neuroscience: Basic and Clinical, on a special issue devoted to estrogen and the autonomic nervous system

Teaching Activities: PHSL 800 – Medical Physiology 3 – 3 hour lectures PHSL 846 – Advanced Neuroscience 2 – 2 hour lectures

COPD Small Group 2 – 2 hour sessions

Research personnel: Anuradha Chakrabarty, Ph.D. Senior Scientist

Sarah Tague, PhD, Senior Scientist Aritra Bhattacherjee, PhD, Post-doctoral fellow Zhaohui Liao, MD, Research Associate Dora Krizsan-Agbas, PhD, Senior Scientist Ying Mu, Research Associate

78

John A. Stanford, Ph.D., Associate Professor My research is focused on preclinical models of normal aging and age-related diseases and conditions that affect motor function, such as Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and neonatal hyperbilirubinemia (kernicterus). We are currently examining the effects of isometric strength training on neuromuscular denervation in aged rats and in the SOD1-G93A rat model of ALS. Our most recent studies involve characterizing behavioral and neurological abnormalities in the Gunn rat model of kernicterus. Meetings Attended:

December 11, 2015- December 13, 2015 – 26th International Symposium on ALS/MND in Orlando, FL

April 28, 2016- April 30, 2016 - 23rd Annual Meeting of the American Society for Neural Therapy and Repair in Clearwater Beach, FL

June 26, 2016 – June 28, 2016 National IDeA Symposium for Biomedical Research Excellence in Washington, DC

Committee Activities: Departmental Member, Finance Committee

Student Committee Service Member, Chuankai Zhou, Physiology, Ph.D. Member, Jason Flor-Sistante, Physical Therapy & Rehabilitation Science, Ph.D. Member, Matthew Stroh, Biochemistry,Ph.D. Member, Sidrah Sheik, KCUMB College of Biosciences II year

Research track program Member, Sha Neisha Williams, KCUMB College of Biosciences II

year Research track program KUMC

Member, Rodent Behavior Advisory Committee Member, KUMC Neuroscience Graduate Program Advisory Committee Member, KIDDRC Core B Advisory Committee

Member, Society for Neuroscience Kansas City Chapter Executive Committee

Co-President, Society for Neuroscience Kansas City Chapter Member, KUMC Faculty Council

Member, KUMC IGPBS Admissions Committee (Neuroscience representative)

Program Director, KUMC Biomedical Research Training Program Campus Coordinator, K-INBRE Program Director and KUMC Community

Member, Teachers and Students for Community Oriented Research Education Advisory Board Steering Committee

79

Dr. Stanford (continued) National

Chair and awards committee, National IDeA Symposium for Biomedical Research Excellence

Editorial and Grant Reviews: Editorial Board, Journal of Neurodegenerative Diseases

Ad hoc Reviewer, Journal of Alzheimer’s disease Ad hoc Reviewer, Journal of Diabetes Research Ad hoc Reviewer, Neuroscience Ad hoc Reviewer, Neuroscience Letters Ad hoc Reviewer, Journal of Cerebral Blood Flow and Metabolism

Ad hoc Reviewer, NIH CSR Motor Function Speech and Rehabilitation (MFSR) scientific review panel Ad hoc Reviewer, Pharmacology, Biochemistry & Behavior Ad hoc Reviewer, Neurotoxicity Research

Ad hoc Grant Reviewer, Research Grants Council (Hong Kong)

Seminars Presented: August 12, 2015 – “Effects of Targeted Muscle Resistance Training in Rat

Models of ALS and Aging”. Center of Excellence in the study of Dental and Musculoskeletal Tissue (CEMT) Seminar Series, University of Missouri, Kansas City, MO,

November 3, 2015 – “Preclinical Studies of Bilirubin-Induced Neurological Dysfunction.” Department of Pharmacology, Toxicology & Therapeutics Seminar Series, University of Kansas Medical Center, Kansas City, KS,

February 5, 2016 – “Measuring Motor Function in Animal Models of Age-Related Disease.” Department of Laboratory Animal Resources Hot Topics Seminar Series, University of Kansas Medical Center, Kansas City, KS,

Teaching Activities: PHSL 846 – Advanced Neuroscience Course Director Summer 2015, 9 – 2 hour sessions Summer 2016, 9 – 2 hour sessions

CORE 840 – Brain and Behavior 4 – 4 hour sessions

80

Dr. Stanford (continued) Research personnel:

Kimberly Stanford, MA – Research Associate: Resistance training and neuromuscular junctions in aging and ALS

Delin Ma, MD – Visiting Scholar: Preclinical Studies of Kernicterus Lily Gan, MD – Visiting Scholar: Preclinical Studies of ALS, Kernicterus, and

Parkinson’s disease Cameron Banning – Undergraduate Student: Preclinical Studies of ALS Bethany Snyder – High School Student: Preclinical Studies of ALS Jane Yang, PhD – Postdoc: Preclinical Studies of Kernicterus Sean Riordan, PhD – Postdoc: Preclinical Studies of Kernicterus Tate Knudsen – Undergraduate Student: Preclinical Studies of Kernicterus Bryn O’Meara – High School Student: Resistance training and aged

neuromuscular junctions Quincy Stanford – High School Student: Resistance training and aged

neuromuscular junction

81

Joseph S. Tash, Ph.D., Professor My research interests, funded by NIH, focus on the discovery and development of reversible non-hormonal male contraceptives. In addition, my NASA funded research is focused on elucidating the impact of long term space flight on reproductive health in males and females. During the last year I was awarded a 6 month Sabbatical by the university, which was supported by a Burroughs-Welcome Fund Collaborative Travel grant. I devoted the Sabbatical to gain experience in female reproductive biology at the Oregon National Primate Research Center in collaboration with the investigators in the U54 Center: Contraception by Blockade of Periovulatory Events in Primates. During the Sabbatical we accumulated promising data to support development of a new area of non-hormonal contraceptive drug discovery in females. Meetings Attended:

31st Annual Meeting of the American Society for Gravitational and Space Research. Alexandria, VA; Nov 10-14, 2015

NICHD CRB U54/U01 Steering Committee meeting, Pullman, WA, Oct 26-27, 2015

Committee Activities: Departmental Member, Department Promotion and Tenure Committee Teaching Activities:

CORE 830 – Reproduction and Sexuality. Lecture “Prospects for Male Contraception” to first year medical students

Research personnel:

Lesya Holets, Ph.D., Senior Scientist, Cell-cycle regulatory kinases as targets for male contraceptive drug development, H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents

Hannah Horky, Research Assistant, Cell-cycle regulatory kinases as targets for male contraceptive drug development.

Eric Yarns, Research Assistant, Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents, Female reproductive health: Space flight induced ovarian & estrogen signaling dysfunction, adaptation, and recovery

82

John P. Thyfault, Ph.D., FACSM, Associate Professor

1. Links between fatty liver, hepatic mitochondrial dysfunction, and low aerobic fitness and the role that hepatic PGC-1a may be playing in this process

2. Role of hepatic mitochondrial function to impact systemic metabolism and regulation of energy intake and physical activity

3. Role of physical activity and inactivity to modulate insulin action and glycemic control 4. Impact of statins to negatively impact the ability of exercise training to improve

skeletal muscle mitochondrial content and aerobic fitness

Invited Presentations: August 17, 2015 Statins and Exercise Training. Mitochondrial Physiology, From

Organelle to Organism Meeting, Copenhagen, Denmark June 17, 2016 – Hepatic fitness and metabolic fitness. Integrated Medicine:

Physical Activity is a Core Tip Annual Conference. Basun, Korea

Meetings Attended: November 2-6, 2016 - The Obesity Society – Los Angeles, CA June 14-18th, 2016 - Impact conference – Busan Korea

Committee Activities

Student Committee Service Member, Ian Huck, Pharmacology, Toxicology, Therapeutics, Ph.D Member, Michael Cooper, Anatomy, IGBPS Member, Ashley Ward, Committee Member, IGBPS Member, Shaima Alothman, Physical Therapy, Ph.D, Member, Yuan Li, Pharmacology, Toxicology, Therapeutics, Ph.D, Editorial and Grant Reviews:

Member, NIH Integrative Physiology of Obesity and Diabetes (IPOD) study section

Ad hoc Reviewer, Diabetes Ad hoc Reviewer, AJP Endocrinology and Metabolism Ad hoc Reviewer, Diabetologia Ad hoc Reviewer, Physiological Genomics Ad hoc Reviewer, Experimental Behavior

Ad hoc Reviewer, Experimental Physiology Ad hoc Reviewer, Exercise Sports Science Reviews Editorial Board Reviewer, Applied Physiology Nutrition and Metabolism Editorial Board Reviewer, Experimental Physiology Editorial Board Reviewer, Physiological Genomics

83

Dr. Thyfault (continued) Seminars Presented:

September 23, 2015 - Statins negatively impact muscle health. Pharmacology, Toxicology, and Therapeutics Department Seminar, KUMC, Kansas City, KS

November 17, 2015 - Hepatic fitness impacts susceptibility for metabolic disease. East Carolina University – Ed Tapscott Memorial Lecture, Greenville, NC

April 21, 2016 - Hepatic fitness and metabolic health. University of Jyvaskyla, Finland

June 17, 2016 - Hepatic fitness and metabolic health. University of Jyvaskyla, Finland

Research Personnel:

Colin McCoin, Ph.D. – Post-Doctoral Fellow: Hepatic mitophagy impacted by lipids and exercise

E. Matthew Morris, Ph.D. – Post-Doctoral Fellow: Role of hepatic mitochondrial function to impact weight gain

Julia Allen – Lab Manager Adrianna Maurer, Masters student (Nutrition and Dietetics) – Fitness and bile

acids

84

Shahid Umar, Ph.D., Associate Professor Research in my laboratory is focused on the role of bacterial infection in colonic crypt hyperplasia and/or inflammation and cancer. Specific research areas include: (a)

Epigenetic regulation of cross-talk between components of the Wnt/-catenin and Notch

and NF-B and Notch pathways in relation to complex inter-relationship amongst cell proliferation, inflammation and cancer; (b) Cancer Stem Cells, (c) miRNAs, (d) EMT and (e) mechanism(s) of chemoprevention by dietary factors and its novel derivatives. Committee Activities: Departmental Member, Faculty Development Committee

KUMC Member, Institutional Animal Care and Use Committee (IACUC)

External Advisor, Carla Kantara, Neurosciences and Cell Biology, Ph.D. External Advisor, Weijuan Wu, Physiology, Ph.D. Oral Examiner, Ashley Ward, Molecular & Integrative Physiology, Ph. D. Oral Examiner, Zelha Nil, Stowers/Molecular & Integrative Physiology, Ph. D Oral Examiner, Josh Curry, Kidney Institute/Molecular & Integrative Physiology, Ph.D. Oral Examiner, Blake Ebner, Stowers/Molecular & Integrative Physiology Ph.D. Oral Examiner, Afrin Syed, Cancer Biology, Ph.D.

Editorial and Grant Reviews: Ad hoc Reviewer, American Journal of Physiology Ad hoc Reviewer, Biochemical Pharmacology Ad hoc Reviewer, Biomed Central Ad hoc Reviewer, Cancer Biology and Therapy Ad hoc Reviewer, Cancer Research Ad hoc Reviewer, Carcinogenesis Ad hoc Reviewer, Digestive Diseases and Sciences Ad hoc Reviewer, FEBS Letters Ad hoc Reviewer, Mediators of Inflammation Ad hoc Reviewer, Molecular Carcinogenesis

Ad hoc Reviewer, Oncogene Ad hoc Reviewer, Oncotarget

Ad hoc Reviewer, PLoS One Ad hoc Reviewer, Scientific Reports Ad hoc Reviewer, Stem Cells and Development Ad hoc Reviewer, The Journal of Pathology Editorial Board Member, Annals of Carcinogenesis Editorial Board Member, World Journal of Clinical Oncology Editorial Board Member, PLOS One Reviewer, NIDDK’s Fellowship in Digestive Diseases and Nutrition

85

Dr. Umar (continued) Teaching Activities: GSMC 851 - Molecular Genetics (IGPBS) 3 – 2 hour lectures PHSL 842- Comprehensive Human Physiology 3-2 hour lectures Research personnel:

Dr. Ishfaq Ahmed - Senior Scientist Dr. Badal C. Roy - Senior Scientist Ms. Renny Ma – Student Volunteer Ms. Sierra Layton – Student Volunteer Dr. Salman Khan – Resident Volunteer

86

Michael W. Wolfe, Ph.D., Associate Professor Research in my laboratory has recently been focused in two areas. The first investigates the role of estrogen receptor alpha in growth and metabolism using receptor knockout rats. We are focusing on sex-specific differences in hepatic gene expression. In the second area, we are determining the role of SATB homeobox proteins in regulating placental development. These studies focus on SATB regulation of the epigenome and transcriptome in proliferating and differentiating trophoblasts. Meetings Attended:

12th Annual Gilbert S. Greenwald Symposium on Reproduction, October 22-23, 2015, Kansas City, KS

Committee Activities: Departmental

Director, Graduate Education Chair, Graduate Student Advisory Committee

Student Committee Service Member, Jessica Foster, Pathophysiology, M.S. Member, Bhaswati Bhattacharya, Pathophysiology, Ph. D. Member, Jessica Johnson-Venugopal, Physiology, Ph.D. Member, Margaret Pruitt, Physiology, Ph. D Member, Eric Young, Cancer Biology, MD/Ph.D Chair, Oral Comprehensive Exam for Zahraa Alali, Physiology, Ph.D. Chair, Oral Comprehensive Exam for Younshim Park, Physiology, Ph.D.

KUMC Chair, Phase I committee – Musculo-Skeletal module review committee Chair, Manuscript dispute resolution committee (appointed by Dr. Peter Smith) Officer, KUMC Research Integrity Member, KUMC Graduate Council Member, IGPBS Advisory Board Member, ACE Committee on Assessment, Remediation and Enrichment Member, Phase I committee for Medical curriculum Member, Committee developing program for Responsible Conduct of Research

Editorial and Grant Reviews:

Member, University of Missouri Research Board Reviewer, BRTP training grant proposals Reviewer, Journal of Assisted Reproduction and Genetics

87

Dr. Wolfe (continued) Teaching Activities: GSMC 856, Introduction to Research Ethics Course Director 6 – 2 hour sessions

PHSL 842, Comprehensive Human Physiology Course Director

10 – 1 hour lectures CORE 825, Renal-Endocrine Module Course Director 7 – 1-2 hour lectures CORE 830, Reproduction and Sexuality Module

3 – 1 hour lectures Med Education – Sat in on PBLs and Histopathology labs for the RE module 6 – 2 hour sessions Med Education – Remediation for Renal-Endocrine Module 2 – 2 hour sessions Research personnel:

Anamika Ratri, Graduate student Dr. Soma Paul Dr. Min Luo, Visiting Scientist Shaon Borosha, Volunteer Dr. Mina Moussavi, Volunteer – Instructor at University of Central Missouri

88

John G. Wood, Ph.D., Associate Professor Currently our major goal is to examine mechanisms responsible for the microvascular inflammatory response following cutaneous thermal injury. These experiments are in collaboration with Drs. James Howard and Michael Moncure in the Dept. of Surgery. Intravital microscopy is used to quantitate microvascular alterations in mesenteric post-capillary venules. Seminars Presented: February 9, 2016 – Teaching to Large Groups (Residents as Teachers), KUMC Meetings Attended

April 2-6, 2016 – Experimental Biology, San Diego, California.

Committee Activities: Student Committee Service Member, Thesis Committee, Blake Ebner, Physiology, MD/Ph. D. Member, Thesis Committee, James Weemhoff, Pharmacology, Ph. D. Member, Thesis Committee, Jessica Venugopal, Physiology, Ph. D. Member, Thesis Committee, Amy Cantilena, Physiology, Ph. D. Member, Thesis Committee, Yuchao Xie, Pharmacology, Ph. D. KUMC Member, Academic and Professionalism Committee

Member, Prematriculation planning committee Member, Delp Academic Society Member, Admissions/Selection Committee Member, Institutional Animal Care and Use Committee Member, Phase I Committee Member, Committee for Systematic Review of the Blood & Lymph Module Chair, Dept. of Surgery Research Committee Chair, Dept. of Surgery Research Strategic Planning Committee Member, Dept. of Surgery Resident Education Committee Member, Interview applicants for residency in Dept. of Surgery Member, Education Council Member, Committee for Systematic Review of the Integration &

Consolidation Module Member, ACE Curriculum: Physiology Discipline Leader

89

Dr. Wood (continued) Teaching Activities: First Year Medical Curriculum – Cardiopulmonary Module 22 hours lecture 4 hours small group discussion facilitator 8 hours simulation sessions 5 hours case presentations facilitator Pre-Matriculation Program Course Director 13 hours lecture Integration and Consolidation 3 hours lecture PHSL 842 – Comprehensive Human Physiology 13 hours lecture Research Personnel

Naomi Holloway, Research Associate Jonathan Warren, MD, Resident in Dept. of Surgery Melissa Krystel-Whittemore, Fourth year medical student Nicholas Duethman, Fourth year medical student Colton Nielson, Fourth year medical student

Academic Honors: Above and Beyond Award from First Year Medical Students

Second Year Outstanding Lecturer Cardiopulmonary: First Year Outstanding Medical Module