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Department of Pharmaceutical Chemistry
Courses Specifications
2017-2018
1 | P a g e
Contents
Medicinal Chemistry-1 ....................................................................................... 2
Medicinal Chemistry-2 ....................................................................................... 7
Medicinal Chemistry-3 ..................................................................................... 12
Drug Design and Development......................................................................... 17
Pharmaceutical Organic Chemistry-1 ............................................................. 22
Pharmaceutical Organic Chemistry-2 ............................................................. 27
Physical Chemistry ............................................................................................ 33
Pharmaceutical Analytical Chemistry-1 ......................................................... 38
Pharmaceutical Analytical Chemistry-2 ......................................................... 43
Quality Control .................................................................................................. 49
Food Analysis ..................................................................................................... 56
General physics .................................................................................................. 60
Mathematics ....................................................................................................... 65
Advanced instrumental analysis ...................................................................... 69
2 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Medicinal Chemistry-1
Course Code: PC 331
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Fall semester 2017/2018 Level three
Prerequisite: Pharmaceutical Organic Chemistry-2 (PC 211)
Credit hours: Lecture: 2 Practical: NA Total: 2
2. Course Aims:
To enable the student to gain an understanding of the physicochemical properties of drugs and
their biotransformation, the structures and uses of different chemotherapeutic agents, their
modes of action; the correlation between chemical structures and biological activities.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A2
a1. Recognize the physico-chemical properties of drugs.
a2. Explain how chemical properties of drugs will influence in vivo and in vitro
behavior.
A5 a3. Realize how drug-receptor interactions occur and relate chemical structure to
biological activity.
A13
a4. Illustrate the different metabolic biotransformation pathways of drugs.
a5. Classify different chemotherapeutic agents; identify their chemistry,
nomenclature, molecular mode of action and their spectrum of activity.
b. Intellectual Skills:
At the end of this course, student should be able to:
B16 b1. Think critically about the chemistry of drug molecules and relate the specific
structural features to target receptor affinity.
B9 b2. Select the proper drugs for various disease conditions based on
understanding structural activity relationship and drug chemistry.
B16
b3. Specify the pharmacological class of given chemical structures.
b4. Predict the major pharmacological action and therapeutic activity of a given
drug bases on the molecular structure.
b5. Conclude pathways of metabolic degradation based on vulnerability of drug
functional groups to metabolizing enzymes.
3 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C9 c1. Raise the awareness on rationale use of chemotherapeutic agents based on an
understanding of drug chemistry.
C10 c2. Describe proper use of antibiotics and prescribe therapeutic
recommendations based on an understanding of drug chemistry.
C13
c3. Deduce relative receptor affinity, metabolic vulnerability and distribution
potential based on drug chemistry.
c4. Examine potential drug-drug, and drug-food interactions, and potential side
effects based on the structural features of drugs.
C21 c5. Manage side effects and toxicity of chemotherapeutic agents and apply
oncology supportive case.
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team to perform the required tasks.
D6 d2. Develop the skills required for continued self-professional development and
self-learning.
D11 d3. Generate effective and reasonable solutions for rising problems based on the
available information.
4. Contents:
4.1.Lectures:
Study
week Topics
No. of
Credit Hours
1.
Introduction
Physicochemical Properties and Drug Action
Major processes involved in drug action
Physicochemical parameters
2
2.
Introduction
Physicochemical Properties and Drug Action
Physicochemical parameters
Drug-Receptor interactions
2
3. Drug Metabolism : phase I , phase II 2
4.
Chemotherapeutic Agents
Antibacterial Agents
Mechanisms of antibacterial action
Antibiotics:
Antibiotics which inhibit cell wall synthesis
Penicillins, Cephalosporins, Non classical β-lactams
+ Quiz 1
2
5.
Antibiotics which impair protein synthesis
Aminoglycosides,Tetracyclines
Macrolides, Chloramphenicol
2
6. Agents which act on nucleic acid transcription and replication
Quinolones and fluoroquinolones 2
7. Antifungal agents
Azoles, Antifungal Antibiotics. 2
4 | P a g e
4.2.Practical: Not applicable
5. Teaching and Learning Methods:
5.1. Lectures using data show and whiteboard and Tutorials
5.2. Researches and Homework
5.3. Learning Management System (LMS)
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam to assess professional and practical skills.
3. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
5. Quizzes to assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment all over the term
Assessment 3 Oral exam 14th & 15th weeks
Assessment 4 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
8. Quiz 2
9.
Antiviral Agents
Nucleoside Antagonists, Non-Nucleoside inhibitors of
reverse transcriptase
2
10. Antiviral Agents
Protease Inhibitors, Neuroaminidase inhibitors 2
11. Cancer chemotherapy: Antineoplastic drugs:
Tumor Cell Properties, Alkylating Agents 2
12. Antimetabolites 2
13. Miscellaneous Agents 2
14. Final Exam
Total:
2 credit hours 15.
5 | P a g e
- Assignment 5
2. Final-Term Exam 65
3. Oral Exam 10
Total 100%
7. List of References:
No. Reference Type
1.
"Wilson and Gisvold’s Textbook of Organic Medicinal and
Pharmaceutical Chemistry" Twelfth Edition, (J. H. Block and J. M.
Beale Jr; Editors), Lippincott Williams & Wilkins, Philadelphia, PA,
2012.
Foye’s Principles of Medicinal Chemistry", 8th edition, (David
A.Williams, Thomas L Lemke & ,William O .Foye Editors),
Lippincott Williams & Wilkins, 2013.
textbook
2. http://www.phc.vcu.edu/othercoolsites.html
http://pharmacy.creighton.edu/ website
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
Introduction
Physicochemical Properties and Drug
Action
Major processes involved in drug
action
Physicochemical parameters
a1, a2 b1 c3, c4 --
2.
Introduction
Physicochemical Properties and Drug
Action
Physicochemical parameters
Drug-Receptor interactions
a1, a2,
a3 b1 c3, c4 --
3. Drug Metabolism : phase I , phase II a4 b5 c3 --
4.
Chemotherapeutic Agents
Antibacterial Agents
Mechanisms of antibacterial action
Antibiotics:
Antibiotics which inhibit cell wall synthesis
Penicillins, Cephalosporins,
Non classical β-lactams
a3, a4,
a5
b1, b2,
b3, b4,
b5
c1, c2,
c3, c4 d1
5.
Antibiotics which impair protein synthesis
Aminoglycosides,Tetracyclines
Macrolides, Chloramphenicol
a2, a3,
a4, a5
b1, b2,
b3, b4,
b5
c1, c2,
c3, c4 d2
6.
Agents which act on nucleic acid
transcription and replication
Quinolones and fluoroquinolones
a2, a3,
a4, a5
b2, b3,
b4
c1, c2,
c3, c4 d3
6 | P a g e
7. Antifungal agents
Azoles, Antifungal Antibiotics.
a3, a4,
a5
b2, b3,
b4
c1, c3,
c4 d2, d3
9.
Antiviral Agents
Nucleoside Antagonists, Non-
Nucleoside inhibitors of reverse
transcriptase
a2, a3,
a4, a5
b2, b3,
b4
c1, c3,
c4 d1, d3
10.
Antiviral Agents
Protease Inhibitors, Neuroaminidase
inhibitors
a1, a3,
a4, a5
b2, b3,
b4
c1, c3,
c4 d2, d3
11.
Cancer chemotherapy:
Antineoplastic drugs:
Tumor Cell Properties,
Alkylating Agents
a2, a3,
a4, a5
b1, b2,
b3, b4
c1, c3,
c4, c5 d1,d3
12. Antimetabolites a2, a3,
a4, a5
b1, b2,
b3, b4
c1, c3,
c4, c5 d2, d3
13. Miscellaneous Agents a2, a3,
a4, a5
b2, b3,
b4
c1, c3,
c4, c5
d1, d2,
d3
Name Signature
Course Coordinator: Prof. Dr. Dina El-Sherbiny
Head of Department: Prof. Dr. Dalia Rashad El-Wasseef
Approval Date 10 / 9 /2017
7 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Medicinal Chemistry-2
Course Code: PC 332
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Spring Semester 2017/2018 Level three
Prerequisite: Medicinal Chemistry-1
Credit hours: Lecture: 2 Practical: 1 Total: 2
2. Course Aims:
This course aims to enable the student to gain an understanding of the following areas of
study: drugs affecting the autonomic system, cardiovascular (CVS) systems, diuretics,
antihistamines, antiulcers and local anesthetics, their mode of action, the correlation between
chemical structures and biological activities, different synthetic pathways of representative
examples, the metabolic biotransformation and evaluation of the contents of pharmaceutical
preparations.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A5
a1. Identify drug receptor interaction and molecular effect of drugs acting on
autonomic nervous system
a2. Recognize the structure activity relationships (SAR) of Cardiovascular drugs
and other drugs to optimize drug action.
A13 a3.
Recall nomenclature, therapeutic uses & metabolic pathways of Autonomic
and cardiovascular drugs.
a4. Describe different theories of mechanisms of action of the studied drugs.
b. Intellectual Skills:
At the end of this course, student should be able to:
B9 b1. Select proper drugs for various autonomic and CVS disease conditions based
on their pharmacological activity.
B16
b2. Predict Chemical properties of the studied drugs based on molecular structure.
b3. Conclude the major pharmacological action and biotransformation of a given
drug based on the chemical structure.
b4. Relate the specific structural features of drug to target receptor affinity
B3 b5. Determine suitable methods of drug analysis based on their chemical
structure.
8 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C2 c1. Handle and dispose chemicals.
C8 c2 Manipulate laboratory instruments and equipment safely and
Efficiently.
C9 c3. Raise public awareness of rational use of CVS drugs.
C13 c4. Examine risks concerning drug interactions, adverse reaction and
incompatibilities.
C14 c5. Use different quantitative chemical methods for assay of pharmaceutical
preparations.
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Support a team work in the application of the analytical methods for
determination of different dosage forms.
D6 d2. Develop the skills required for self-learning.
D11 d3. Generate effective and reasonable solutions for rising problems based on the
available information.
4. Contents:
4.1.Lectures:
Study
week Topics
No. of
Credit Hours
1. Introduction to ANS :Adrenergic drugs 2
2. Cholinergic drugs 2
3. CVS:
Antihypertensives 2
4. Antihypertensives + Quiz 1 2
5. H1–antagonists 2
6. Antiulcer drugs 2
7. Local anesthetics 2
8. Quiz 2
9. Diuretics 2
10. Antiarrhythmics 2
11. Anticoagulants 2
12. Antihyperlipidimics 2
13. Antianginal 2
14. Final Exam
Total:
2 credit hours 15.
9 | P a g e
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Colorimetric assay of epinephrine 1
2. Spectrophotometric assay of ranitidine 1
3. Spectrophotometric assay of furosemide 1
4. Colorimetric assay of benzocaine 1
5. Practical exam 1
6. Chemdraw 2D 1
7. Chemdraw 2D 1
8. Quiz 2
9. Chemdraw 2D 1
10. Chemdraw 3D 1
11. Chemdraw 3D 1
12. Chemdraw 3D 1
13. Practical Exam 1
14. Final Exam
Total:
1 credit hour 15.
5. Teaching and Learning Methods:
5.1. Lecture using data Show and white board.
5.2. Homework and assignments.
5.3. Laboratory equipment.
5.4. Computers and computer lab.
5.5. Learning Management System (LMS).
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam to assess professional and practical skills.
3. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
5. Quizzes to assess knowledge, understanding and intellectual skills.
10 | P a g e
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment (research) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Oral exam 14th & 15th weeks
Assessment 6 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment (research) 5
2. Final-Term Exam 40
3. Oral Exam 10
4. Practical Exam 25
Total 100%
7. List of References:
No. Reference Type
1.
-"Wilson and Gisvold’s Textbook of Organic Medicinal and
Pharmaceutical Chemistry" 12th Edition, (J. H. Block and J. M.
Beale Jr; Editors), Lippincott Williams & Wilkins, Philadelphia, PA,
2012.
-Foye’s Principles of Medicinal Chemistry", 8th edition, (David
A.Williams, Thomas L Lemke & ,William O .Foye Editors),
Lippincott Williams & Wilkins, 2013.
-Textbook of Medicinal Chemistry Vol I, V. Alagarsamy 2nd Ed.,
Elsevier 2013
textbook
2. http://www.phc.vcu.edu/othercoolsites.html website
8. Matrix of course contents versus ILOs:
8.1.Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Introduction to ANS :Adrenergic drugs a1, a2,
a3, a4
b1, b2,
b4 c4 --
2. Cholinergic drugs a1, a2,
a3, a4
b1, b2,
b3, b4 c4 --
3. CVS:
Antihypertensives
a2, a3,
a4
b1, b2,
b3, b4 c3, c4 --
11 | P a g e
4. Antihypertensives a2, a3,
a4
b2, b3,
b4 c3, c4 --
5. H1–antagonists a2, a3,
a4 b2, b4 c4 d2,d3
6. Antiulcer drugs a2, a3,
a4
b2, b3,
b4 c4 d2,d3
7. Local anesthetics a2, a3,
a4
b3, b4,
b5 c4 d2,d3
9. Diuretics a2, a3,
a4
b1, b3,
b4 c3, c4 d2,d3
10. Antiarrhythmics a2, a3,
a4
b1, b3,
b4 c3, c4 d2,d3
11. Anticoagulants a2, a3,
a4
b1, b3,
b4 c3, c4 d2,d3
12. Antihyperlipidimics a2, a3,
a4
b1, b3,
b4 c3, c4 d2,d3
13. Antianginal a2, a3,
a4
b1, b3,
b4 c3, c4 d2,d3
8.2.Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Colorimetric assay of epinephrine -- b1 c1,c2, c5 --
2. Spectrophotometric assay of ranitidine -- b1 c1,c2, c5 --
3. Spectrophotometric assay of
furosemide -- b1 c1,c2, c5 --
4. Colorimetric assay of benzocaine -- b1 c1,c2, c5 d1, d2,
d3
6. Chemdraw 2D -- -- c2 d2, d3
7. Chemdraw 2D -- -- c2 d2, d3
9. Chemdraw 2D -- -- c2 d2, d3
10. Chemdraw 3D -- -- c2 d2, d3
11. Chemdraw 3D -- -- c2 d2, d3
12. Chemdraw 3D -- -- c2 d2, d3
Name Signature
Course Coordinator: Prof. Dalia Rashad El-Wasseef
Head of Department: Prof. Dalia Rashad El-Wasseef
Approval Date 05/2/2018
12 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Medicinal Chemistry-3
Course Code: PC 433
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Fall Semester 2017/2018 Level Four
Prerequisite: Medicinal Chemistry-2 (PC 332)
Credit hours: Lecture: 2 Practical: NA Total: 2
2. Course Aims:
This course aims to enable the student to gain an understanding of the following area of study:
analgesics , Antiaging , CNS depressant and CNS stimulant drugs, Insulin and related drugs,
male and female sex hormones adrenocorticoids their modes of action; the correlation
between chemical structures and biological activities drugs and their biotransformation
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A5
a1. Describe pharmacodynamics and drug receptor interactions of analgesics
CNS and hormones.
a2. Illustrate structure activity relationship (SAR) of different pharmacologically
active analgesics, CNS and hormonal drugs.
A13
a3. Identify nomenclature, therapeutic uses of the studied drugs.
a4. Distinguish different biotransformation pathways of selected drug in each
pharmacologically studied classes.
a5 Describe different theories of drug mechanisms of action of CNS, analgesics
and hormones.
b. Intellectual Skills:
At the end of this course, student should be able to:
B9 b1. Predict proper drugs for various diseases based on their pharmacological
activity.
B15 b2. Estimate health hazards concerning CNS drugs and narcotics use and misuse.
B16
b3. Evaluate chemical properties of drugs in different classes based on molecular
structure.
b4. Conclude the major pharmacological action of a given drug bases on the
chemical structure.
b5. Relate the specific structural features of drug to target receptor affinity.
13 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C9 c1. Raise awareness on drug abuse and misuse of narcotics and Hormones
C10 c2 Describe proper use of CNS drugs, analgesics and hormones based on an
understanding of drug chemistry.
C13 c3.
Examine risks concerning drug interactions, adverse reactions and
incompatibility in different drug classes acting on CNS.
c4. Deduce relative receptor affinity, metabolic vulnerability and distribution
potential based on drug chemistry.
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team.
D6 d2. Develop the skills required for self-learning.
D9 d3. Acquire effective time management.
4. Contents:
4.1. Lectures:
Study
week Topics
No. of
Credit Hours
1.
Opioid Analgesics
Morphine analogs, Morphinans, Benzomorphans,
4-Phenylpiperdines, Opioid Antagonists
2
2.
Nonsteroidal Anti-inflammatory Drugs
Salicylates, Paracetamol and related drugs
Aryl and heteroarylacetic acid, N-Aryl anthranilic acid
Oxicams, Selective COX-2 inhibitors
Drugs used in the management of Gout and hyperuricemia
2
3.
Hormones
Insulin & Male sex hormones
Female sex hormones, Adrenocorticoids
2
4. Central Dopaminergic Signaling agents
Anti-Parkinsonian Drugs + Quiz 1 2
5. CNS stimulants 2
6. Tricyclic antidepressants 2
7. Central Nervous System Depressants
Anxiolytic, Sedatives and Hypnotic agents, Benzodiazepines 2
8. Quiz 2
9. Barbiturates 2
10. General anaesthetics & antiaging 2
11. Antipsychotics
Phenothiazines, Thioxanthenes 2
12. Anticonvulsant& central muscle relaxants 2
14 | P a g e
4.2. Practical: Not applied
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Homework and Assignments
5.3. learning management system (LMS)
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
3. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
4. Quizzes to assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment all over the term
Assessment 4 Oral exam 14th & 15th weeks
Assessment 5 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment 5
2. Final-Term Exam 65
3. Oral Exam 10
Total 100%
13. Anti-Alzheimer Drugs 2
14. Final Exam
Total:
2 credit hours 15.
15 | P a g e
7. List of References:
No. Reference Type
1.
Burger's Medicinal Chemistry, Drug Discovery, and
Development, 7th Edition,2010,Donald J Abraham, David
P.Rotella,Wiley
"Wilson and Gisvold’s Textbook of Organic Medicinal and
Pharmaceutical Chemistry" Twelfth Edition, (J. H. Block and J.
M. Beale Jr; Editors), Lippincott Williams & Wilkins,
Philadelphia, PA, 2012.
Foye’s Principles of Medicinal Chemistry", 7th edition, (David
A.Williams, 8th edition Thomas L Lemke & ,William O .Foye
Editors), Lippincott Williams & Wilkins, 2013.
textbook
2. http://www.phc.vcu.edu/othercoolsites.html
http://pharmacy.creighton.edu/ website
8. Matrix of course contents versus ILOs:
8.1.Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
Opioid Analgesics
Morphine analogs, Morphinans,
Benzomorphans,
4-Phenylpiperdines, Opioid
Antagonists
a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c1 --
2.
Nonsteroidal Anti-inflammatory Drugs
Salicylates, Paracetamol and related
drugs
Aryl and heteroarylacetic acid, N-Aryl
anthranilic acid
Oxicams, Selective COX-2 inhibitors
Drugs used in the management of Gout
and hyperuricemia
a1,a2,
a3,a4,a5
b1,
b3,b4,
b5
c2, c4 --
3.
Hormones
Insulin and related Drugs & Male sex
hormones
Female sex hormones,
Adrenocorticoids
a1,a2,
a3,a4,a5
b1, b4,
b5
c1 , c2,
c4 --
4. Central Dopaminergic Signaling agents
Anti-Parkinsonian Drugs+ Antiaging
a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4 --
5. CNS stimulants a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4
d1, d2,
d3
6. Tricyclic antidepressants a1,a2,
a3,a4,a5
b1, b2,
b4, b5
c2, c3,
c4
d1, d2,
d3
16 | P a g e
7.
Central Nervous System Depressants
Anxiolytic, Sedatives and Hypnotic
agents, Benzodiazepines
a1,a2,
a3,a4,a5
b1, b2,
b4, b5
c2, c3,
c4
d1, d2,
d3
9. Barbiturates a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4
d1, d2,
d3
10. General anaesthetics a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4
d1, d2,
d3
11. Antipsychotics
Phenothiazines, Thioxanthenes
a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4
d1, d2,
d3
12. Anticonvulsant& central muscle
relaxants
a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4
d1, d2,
d3
13. Anti-Alzheimer Drugs a1,a2,
a3,a4,a5
b1, b2,
b3,b4,
b5
c2, c3,
c4
d1, d2,
d3
Name Signature
Course Coordinator: Prof. Dalia Rashad El-Wasseef
Head of Department: Prof. Dalia Rashad El-Wasseef
Approval Date 10/ 9 /2017
17 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Drug Design and Development
Course Code: PC 434
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Spring Semester 2017/2018 Level Four
Prerequisite: Medicinal Chemistry-2 ( PC 332)
Credit hours: Lecture: 2 Practical: NA Total: 2
2. Course Aims:
Dominating the different strategies of drug design and development including molecular
modification and quantitative structure-activity relationship, understanding the drug-receptor
interaction, molecular modeling strategy, and providing a broad and thorough background in
drug design based on drug metabolism.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A5
a1. Identify different drug sources, drug discovery, drug targets, and drug-
receptor interaction.
a2. Outline different phases involved in the development of new drugs.
a3. State the role of QSAR and molecular modeling in the design of new drugs.
a4. Recognize the effect of bioisosterism and stereochemistry on drug action.
a5. Describe the pharmacokinetic issue in drug design and the concept of drug
latentiation.
b. Intellectual Skills:
At the end of this course, student should be able to:
B6 b1. Integrate the principles of bioinformatics, molecular modeling and other
tools to design new drugs.
B16
b2. Predict the physical, chemical properties and biological activity of organic
compounds based on molecular structure and drug-design theories.
b3. Predict the lipophilic and hydrophilic characters of the targeted drugs based
on molecular structure.
b4. Relate the specific structural features of drug to target receptor affinity
(QSAR).
b5. Modify the pharmacokinetic characters of drugs to control relative onset and
duration of action based on drug chemistry.
18 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C15
c1. Prescribe a case history of the discovery and development of modern drugs.
c2. Modify the chemical structure of a given drug to give optimum receptor
binding affinity based on molecular modeling theories.
c3. Manipulate the basic concepts of drug design, development and targeting.
c4. Examine a drug structure and deduce relative receptor affinity.
c5. Deduce metabolic vulnerability, distribution potential, possible and optimal
delivery systems based on the chemical structure of a given drug.
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team to perform the required tasks.
D6 d2. Develop the skills required for continued self-professional development and
self-learning.
D11 d3. Generate effective and reasonable solutions for rising problems based on the
available information.
4. Contents:
4.1.Lectures:
Study
week Topics
No. of
Credit Hours
1.
Introduction to Drug Discovery and Drug Development
Phases involved in Development of New Drugs
Drug withdrawal, Sources of Drugs
2
2.
Drug receptors and binding sites
Methodology in Drug Design:
Molecular modeling and docking
2
3.
Molecular simplification (Bond disconnection and design of
fragments of the lead).
Molecular association and design of rigid analogs.
2
4. Skeletal variation (Changing size and shape)
Bioisosterism and stereochemistry + Quiz 1 2
5. Molecular modification based on drug metabolism. 2
6. QSAR
Topliss scheme and Craig plot 2
7. Prodrugs for increased drug absorption and distribution. 2
8. Quiz 2
9. Prodrugs for increased drug water solubility. 2
10. Prodrugs for site specification and targeting. 2
11. Prodrugs for controlled and slow drug release. 2
19 | P a g e
4.2. Practical: Not applicable
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Tutorials
5.3. Researches and Homework
5.4. Learning Management System
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
3. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
4. Quizzes to assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment (research) all over the term
Assessment 4 Oral exam 14th & 15th weeks
Assessment 5 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment (research) 5
2. Final-Term Exam 65
3. Oral Exam 10
Total 100%
12. Prodrugs for reducing toxicity and side effects. 2
13. Bioprecursor Produgs+ Mutual Prodrugs. 2
14. Final Exam
Total:
2 credit hours 15.
20 | P a g e
7. List of References:
No. Reference Type
1.
“An Introduction to Medicinal Chemistry”, 5th edition, Graham L.
Patrick editor, Oxford university press INC., New York, USA,
2013. ISBN: 9780199697397.
Foye’s Principles of Medicinal Chemistry", 8th edition, (David
A.Williams, Thomas L Lemke & ,William O .Foye Editors),
Lippincott Williams & Wilkins, 2013.
“The Organic Chemistry of Drug Design and Drug action" 2nd
Edition, Richard. B. Silverman, Editor, Academic Press, 2004.
textbook
2. https://www.pdfdrive.com/medicinal-chemistry-books.html website
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
Introduction to Drug Discovery and Drug
Development
Phases involved in Development of New
Drugs
Drug withdrawal, Sources of Drugs
a1, a2 b1 c1, c3 ---
2. Drug receptors and binding sites
Molecular modeling and docking a1, a3
b1, b2,
b3, c2,c3, c4 --
3.
Molecular simplification (Bond
disconnection and design of fragments of
the lead).
Molecular association and design of rigid
analogs.
a3 b2, b3 c2, c4 --
4.
Skeletal variation (Changing size and
shape)
Bioisosterism and stereochemistry
+ Quiz 1
a3, a4 b2, b3 c2, c4 --
5. Molecular modification based on drug
metabolism. a5 b5 c5 d1
6. QSAR
Topliss scheme and Craig plot a3 b4 c2,c4 d1, d2
7. Prodrugs for increased drug absorption and
distribution. a3, a5 b5 c2, c4,c5 d1, d2
21 | P a g e
9. Prodrugs for increased drug water
solubility. a5 b5 c2, c5 d1, d3
10. Prodrugs for site specification and
targeting. a5 b5 c2, c5 d1, d3
11. Prodrugs for controlled and slow drug
release a5 b5 c2, c4,c5
d1, d2,
d3
12. Prodrugs for reducing toxicity and side
effects. a5 b5 c2, c4 d1
13. Bioprecursor Produgs + Mutual Prodrugs. a5 b5 c2, c4,c5 d2, d3
Name Signature
Course Coordinator: Prof. Dr. Dina El-Sherbiny
Head of Department: Prof. Dr. Dalia R. El-Wasseef
Approval Date 05/ 2 /2018
22 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Pharmaceutical Organic Chemistry-1
Course Code: PC 111
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Spring Semester 2017/2018 First Level
Prerequisite: Physical Chemistry (PC102)
Credit hours: Lecture: 2 Practical: 1 Total: 3
2. Course Aims:
The aim of the course is to provide students with proper understanding of the basic principles
of organic reactions. In addition, providing a good idea about the stereochemistry of the chiral
organic compounds. The students will be capable to identify certain aliphatic organic
compounds and recognize their chemical properties, synthesis and reactions.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1.
a1. Represent various structural and molecular formulae of different aliphatic
organic compounds.
a2. Name the aliphatic chemical structures according to trivial and IUPAC
nomenclature.
a3. Recognize the chemical properties of various classes of aliphatic organic
compounds.
A4.
a4. Identify different organic functionalities, their properties, introduction and
transformation to each other, concerning aliphatic organic compounds.
a5. Recognize the stereochemistry of the chiral organic molecules through
studying the asymmetric aspects.
b. Intellectual Skills:
At the end of this course, student should be able to:
B5. b1. Predict the IUPAC name of structures of aliphatic organic compounds.
b2. Select appropriate methods for synthesis of aliphatic organic compounds.
B16.
b3.
Think critically about the chemistry of aliphatic organic molecules and relate
their specific structural features to possible synthesis, identification and
physicochemical properties.
b4. Analyze the organic chemistry data and principles essential for
comprehension of other applied chemistry sciences
23 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C4.
c1. Identify different functional groups of organic compounds
c2. Perform identification chemical tests effectively and safely
c3. Handle chemicals and equipment safely
C11. c4. Record data and write practical chemical reports
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3. d1. Work effectively in a team
D6. d2. Practice self-learning and long-life learning
4. Contents:
4.1.Lectures:
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Lab safety 1
2. Physical Characters and Solubility 1
3. Physical Characters and Solubility 1
Study
week Topics
No. of
Credit Hours
1. Basic Concepts of Organic Chemistry 2
2. Alkanes 2
3. Alkenes 2
4. Alkynes + Quiz 1 2
5. Alkyl halides and Nucleophilic Substitution Reactions 2
6. Alcohols and Ethers 2
7. Aliphatic Amines 2
8. Quiz 2
9. Aliphatic Aldehydes and Ketones 2
10. Aliphatic carboxylic acids & their derivatives 2
11. Stereochemistry
Definition, Concepts and types 2
12. Stereochemistry
Conformational Isomers 2
13. Stereochemistry
Configurational Isomers 2
14. Final Written and Oral exam
Total:
2 credit hours 15.
24 | P a g e
4. General Reactions: Sodalime 1
5. General Reactions: Na2CO3, Element Test 1
6. General Reactions: FeCl3 1
7. Alcohols 1
8. Quiz 2
9. Aldehydes and Ketones 1
10. Aldehydes and Ketones 1
11. Aromatic Carboxylic Acids and Salts 1
12. Aliphatic Carboxylic Acids and Salts 1
13. Practical Exam 1
14. Final Written and Oral exam
Total:
1 credit hour 15.
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Laboratory classes
5.3. Homework
5.4. LMS (Moodle), online webinar and Facebook group discussion
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam to assess professional and practical skills.
3. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
5. Quizzes to assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (homework) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Oral exam 14th & 15th weeks
Assessment 6 Written exam 14th & 15th weeks
25 | P a g e
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (homework) 5
2. Final-Term Exam 40
3. Oral Exam 10
4. Practical Exam 25
Total 100%
7. List of References:
No. Reference Type
1. Organic Chemistry, T. W. Graham Solomons, Craig B. Fryhle, and
Scott A. Snyder11th Ed., 2014. textbook
2.
A Microscale Approach to Organic Laboratory Techniques, Donald
L. Pavia, Gary M. Lampman, George S. Kriz, Randall G. Engel, 4th
Ed., 2016.
textbook
3. Vogel's Quantitative Chemical Analysis, J. Mendham, R.C. Denney,
J. D. Barnes, M.J.K. Thomas, 6th Ed., 2006. textbook
4. http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm website
5. http://www.organic-chemistry.org/ website
6. www.orgsyn.org website
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Basic Concepts of Organic Chemistry a1, a2 b1 -- --
2. Alkanes a1, a4 b1-b4 c1, c2 d1, d2
3. Alkenes a1-a4 b1-b4 c1, c2 d1, d2
4. Alkynes a1-a4 b1-b4 c1, b2 d1, d2
5. Alkyl halides
Nucleophilic Substitution Reactions a1-a4 b1-b4 c1-c4 d1, d2
6. Alcohols and Ethers a1-a3 b1-b3 c1-c4 d1, d2
7. Aliphatic Amines a1-a4 b1-b4 c1-c4 d1, d2
9. Aliphatic Aldehydes and Ketones a1-a3 b1-b4 c1-c4 d1, d2
10. Aliphatic carboxylic acids & their
derivatives a1-a4 b1-b4 c1-c4 d1, d2
26 | P a g e
11. Stereochemistry
Definition, Concepts and types
a1-a5 b3, b4 -- d1, d2 12. Stereochemistry
Conformational Isomers
13. Stereochemistry
Configurational Isomers
8.2.Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Lab safety -- -- c2,c3 --
2. Physical Characters and Solubility -- -- c1-c4 --
3. Physical Characters and Solubility -- -- c1-c4 --
4. General Reactions: Sodalime a3, a4 -- c1-c4 d1,d2
5. General Reactions: Na2CO3
Element Test a3, a4 -- c1-c4 d1,d2
6. General Reactions: FeCl3 a3, a4 -- c1-c4 d1,d2
7. Alcohols a3, a4 b3 c1-c4 d1,d2
9. Aldehydes and Ketones a3, a4 b3 c1-c4 d1,d2
10. Aldehydes and Ketones a3, a4 b3 c1-c4 d1,d2
11. Aromatic Carboxylic Acids and Salts a3, a4 b3 c1-c4 d1,d2
12. Aliphatic Carboxylic Acids and Salts a3, a4 b3 c1-c4 d1,d2
Name Signature
Course Coordinator: Dr. Mohammad AbdulWahhab
Head of Department: Prof. Dr. Dalia Rashad El-Wasseef
Approval Date 05/02/2018
27 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Pharmaceutical Organic Chemistry-2
Course Code: PC 211
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Fall Semester 2017/2018 Second Level
Prerequisite: Pharmaceutical Organic Chemistry-1 (PC 111)
Credit hours: Lecture: 2 Practical: 1 Total: 3
2. Course Aims:
The aim of the courses is to provide students with proper understanding of the basic principles
of aromaticity and heterocyclic chemistry. In addition, providing students with reactions and
mechanisms of aromatic compounds. The students will also be capable to synthesize certain
organic compounds and recognize their physicochemical properties.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1.
a1. Represent various structural and molecular formulae of different aromatic
and heterocyclic organic compounds.
a2. Name the majority of aromatic and heterocyclic structures according to
trivial and IUPAC nomenclature.
A4.
a3. Enumerate the methods of identification, synthesis, and purification of
different aromatic and heterocyclic compounds.
a4. Identify different organic functionalities, their properties, and introduction;
concerning aromatic and heterocyclic compounds.
a5. Outline different transformation of functional groups concerning aromatic
and heterocyclic compounds.
b. Intellectual Skills:
At the end of this course, student should be able to:
B5. b1. Design appropriate methods for synthesis of selected aromatic and
heterocyclic compounds.
B16.
b2. Predict the best method for purification of aromatic compounds.
b3. Relate specific structural features of aromatic and heterocyclic compounds to
possible synthesis, identification and physicochemical properties.
b4. Analyze the organic chemistry data and principles essential for
comprehension of other applied chemistry sciences.
28 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C4.
c1. Perform chemical synthesis of selected organic compounds effectively and
safely.
c2. Carry out different purification methods for selected aromatic and
heterocyclic compounds.
c3. Determine the physicochemical characteristics of different aromatic
compounds.
c4. Handle chemicals and equipment concerning synthesis of aromatic
compounds.
C11. c5. Record data and write practical chemical reports.
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3. d1. Work effectively in a team.
D6. d2. Practice self-learning and long-life learning.
4. Contents:
4.1.Lectures:
Study
week Topics
No. of
Credit Hours
1. Aromatic Compounds: Structure of benzene, The concept of
Aromaticity, Nomenclature of aromatic compounds 2
2. Electrophilic Aromatic Substitution, Reactivity and
Orientation. 2
3.
Aryl Halides: Nomenclature of Aryl Halides, Structure of
Aryl Halides, Physical Properties of Aryl Halides, Preparation
of Aryl Halides, Nucleophilic Aromatic Substitution.
2
4.
Arenes, isolated and fused aromatic ring system.
Quiz 1 2
5.
Aromatic Nitro Compounds: Physical properties of nitro
compounds, Preparation of nitro compounds, Reactions of
nitro compounds, Importance of nitro compounds in synthetic
pathways.
2
6.
Aromatic Amines and Diazonium salts: Nomenclature of
amines, Structure of amines and the basicity concept, Physical
properties of amines. Preparation of amines. Reactions of
amino compounds and diazonium salts.
2
7. Phenols: Structure of phenols. Classification and Physical
Properties of phenols. Preparation and reactions of phenols. 2
8. Quiz 2
9.
Aromatic Aldehydes and Ketones: Structure of aldehydes and
ketones. Nomenclature aldehydes and ketones and their
reactions.
2
10. Aromatic carboxylic acids 2
29 | P a g e
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Lab safety and lab equipment 1
2. Crystallization 1
3. Synthesis of iodoform 1
4. Synthesis of azodye 1
5. Synthesis of ethyl acetate 1
6. Synthesis of methyl salicylate 1
7. Synthesis of nitrotoluene 1
8. Quiz 2
9. Synthesis of nitronaphthalene 1
10. Synthesis of acetanilide 1
11. Synthesis of ozazone 1
12. Synthesis of Phenyl urea 1
13. Practical Exam 1
14. Final Exam
Total:
1 credit hour 15.
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Laboratory classes
5.3. Homework
5.4. LMS (Moodle) and Facebook study group
Classification, nomenclature, preparation and reactions
11. Heterocyclic Chemistry Nomenclature, Classification of
heterocycles and Reactivity of heterocycles. 2
12.
Five-membered Heterocycles Typical reactivity of five
membered heterocycles, Synthesis and Reactions of Pyrrole,
Thiophen and Furan.
2
13. Six membered heterocycles.
Synthesis and Reactions 2
14. Final Exam
Total:
2 credit hours 15.
30 | P a g e
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam to assess professional and practical skills.
3. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
5. Quizzes to assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (homework) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Oral exam 14th & 15th weeks
Assessment 6 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (homework) 5
2. Final-Term Exam 40
3. Oral Exam 10
4. Practical Exam 25
Total 100%
7. List of References:
No. Reference Type
1. Organic Chemistry, T. W. Graham Solomons, Craig B. Fryhle, and
Scott A. Snyder11th Ed., 2014. textbook
2. Vogel's Quantitative Chemical Analysis, J. Mendham, R.C. Denney,
J. D. Barnes, M.J.K. Thomas, 6th Ed., 2006 textbook
3. Heterocyclic Chemistry, J. A. Joule, K. Mills, 5th Ed., 2010 textbook
4. http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm website
5. http://www.organic-chemistry.org/ website
6. www.orgsyn.org website
31 | P a g e
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Aromatic Compounds
a1, a2 b2, b3 c1-c5 --
2. Electrophilic Aromatic Substitution
3. Aryl Halides a1-a3 b1-b4 c3 --
4. Arenes, isolated and fused aromatic
ring system a1-a4 b1-b4 c1-c5 d1, d2
5. Aromatic Nitro compounds a1-a5 b1-b4 c3 d1, d2
6. Aromatic Amines and Aromatic
diazonium Salts a1-a5 b1-b4 c1-c5 d1, d2
7. Phenols a1-a5 b1-b4 c3 d1, d2
9. Aromatic Aldehydes and Ketones a1-a5 b1-b4 c3 d1, d2
10. Aromatic Carboxylic Acids a1-a5 b1-b4 c3 d1, d2
11.
Heterocyclic Chemistry a1-a5 b1,b3,b4 c1-c4 d1, d2 12.
13.
8.2.Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Lab safety and lab equipment -- -- c5 --
2. Purification methods a3,a4 b1, b2 c2 --
3. Synthesis of iodoform a3,a4 b1, b2 c1-c5 d1,d2
4. Synthesis of azodye a3,a4 b1, b2 c1-c5 d1,d2
5. Synthesis of ethyl acetate a3,a4 b1, b2 c1-c5 d1,d2
6. Synthesis of methyl salicylate a3,a4 b1,b2 c1-c5 d1,d2
7. Synthesis of nitrotoluene a3,a4 b1,b2 c1-c5 d1,d2
9. Synthesis of nitronaphthalene a3,a4 b1,b2 c1-c5 d1,d2
32 | P a g e
10. Synthesis of acetanilide a3,a4 b1, 2 c1-c5 d1,d2
11. Synthesis of ozazone a3,a4 b1, b2 c1-c5 d1,d2
12. Synthesis of Phenylurea a3,a4 b1, b2 c1-c5 d1,d2
Name Signature
Course Coordinator: Dr. Mohammad AbdulWahhab
Head of Department: Prof. Dalia Rashad El-Wasseef
Approval Date 10/09/2017
33 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Physical Chemistry
Course Code: PC 102
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry Dept.
Academic year/ level: Fall Semester 2017/2018 Level : 1
Prerequisite: None
Credit hours: Lecture: 2 Practical: 1 Total: 3 hours
2. Course Aims:
To study the basic concepts on some topics such as atomic and molecular structure, types of
bonds, periodic table, chemical calculations, and types of chemical reactions and
understanding the basic principles of thermochemistry and thermodynamics of chemical
reactions.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1 a1. Identify the principles of basic theories of thermochemistry, thermodynamics,
physical and chemical properties
A2 a2. Recognize the physicochemical properties of pharmaceutical elements
A4 a3. Enumerate the theories of identification of chemicals
A13 a4. Recall the chemical properties of chemical compounds
b. Intellectual Skills:
At the end of this course, student should be able to:
B3 b1. Determine suitable methods for analysis of chemical compounds according to
elemental species.
B5 b2. Determine appropriate methods for identification of various chemicals
B13 b3. Interpret experimental data based on relevant chemical principles
b4. Conclude practical data depending on structural principles
34 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C2 c1. Handle and dispose chemicals safely
C4 c2. Select appropriate methods for identification of chemicals
C11 c3. Conduct experimental studies, including: analysis and interpretation of the
results
C14 c4. Employ different qualitative chemical methods for assay of raw materials
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team to perform the required tasks
D9 d2. Acquire effective time management skills
D10 d3. Implement writing and presentation skills
4. Contents:
4.1.Lectures:
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Handling of chemicals and safety in laboratories 1
2. Determination of carbonate group 1
3. Determination of sulphur group 1
4. Determination of phosphate group 1
Study
week Topics
No. of
Credit Hours
1. Periodic table 2
2. Energy levels and their characterization 2
3. Electronic configuration 2
4. Properties of periodic table elements + (Quiz 1) 2
5. Chemical bonding 2
6. Types of chemical reactions 2
7. Introduction to quantitative analysis 2
8. Quiz 2
9. Thermochemistry and Thermochemical equations 2
10. Water calorimeter, application of Hess’s law 2
11. Thermodynamics 2
12. Properties of electromagnetic radiations 2
13. Laws of photochemistry 2
14. Final Exam
Total:
2 credit hours 15.
35 | P a g e
5. Determination of nitrate group 1
6. Revision on anions 1
7. Determination of group 1 1
8. Quiz 2
9. Determination of group 2 1
10. Determination of group 3 1
11. Determination of group 4 1
12. Determination of group 5 1
13. Practical Exam
14. Final Exam
Total:
1 credit hour 15.
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Practical Experiments
5.3. Learning Management System (L.M.S)
5.4. Homework
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam To assess knowledge, understanding, and intellectual skills
2. Practical exam To assess professional and practical skills.
3. Course work To assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Quizzes To assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/Activity (Research Activity) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (research activity) 5
2. Final-Term Exam 50
4. Practical Exam 25
Total 100%
36 | P a g e
7. List of References:
No. Reference Type
1. Analytical Chemistry, Gary D. Christian, 6th ed. John Wiely and
Sons,2004, New York. Textbook
2. Fundamentals of Analytical Chemistry, 9th ed. 2014, Douglas,A.
Skoog and Donald M. West.Sounder’s College Publishing, Japan.
Textbook
3. Dean’s Analytical Chemistry Handbook, Pradyot Patanik, Second
Edition, 2004, McGraw Hill, New York
Textbook
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Periodic table a1, a2 -- -- --
2. Energy levels and their characterization a1, a2 b4 -- --
3. Electronic configuration a1, a2,
a3 b4 -- --
4. Properties of periodic table elements a2, a4 b3, b4 c1, --
5. Chemical bonding a1, a2 b4 -- --
6. Types of chemical reactions a1, a3 b1, b2 c2, c3,
c4 d3
7. Introduction to quantitative analysis a1, a4 b1, b2 c2, c3 d3
9. Thermochemistry and Thermochemical
equations a1, a2 b3, b4 c1, c3 --
10. Water calorimeter, application of
Hess’s law
a1, a2,
a3 b2, b3 c1, c3 --
11. Thermodynamics a1, a2 b3, b4 c1, c3 --
12. Properties of electromagnetic
radiations a1 b4 c3 d3
13. Laws of photochemistry a1 b4 c3 d3
8.2. Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Handling of chemicals and safety in
laboratories a1, a2 --- c1 ---
2. Determination of carbonate group a1, a2 b1, b2 c2, c4 d1, d2
37 | P a g e
3. Determination of sulphur group a1, a2 b1, b2 c2, c4 d1, d2
4. Determination of phosphate group a1, a2 b1, b2 c2, c4 d1, d2
5. Determination of nitrate group a1, a2 b1, b2 c2, c4 d1, d2
6. Revision on anions a1, a2 b1, b2 c2,c3 c4 d1, d2,
d3
7. Determination of group 1 a1, a2 b1, b2 c2, c4 d1, d2
9. Determination of group 2 a1, a2 b1, b2 c2, c4 d1, d2
10. Determination of group 3 a1, a2 b1, b2 c2, c4 d1, d2
11. Determination of group 4 a1, a2 b1, b2 c2, c4 d1, d2
12. Determination of group 5 a1, a2 b1, b2 c2, c4 d1, d2
Name Signature
Course Coordinator: Dr. Mary Wahba
Head of Department: Prof. Dr. Dalia El Wasseef
Approval Date 10/09/2017
38 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Pharmaceutical Analytical Chemistry-1
Course Code: PC 121
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry Dept.
Academic year/ level: Spring Semester 2017/2018 Level: 1
Prerequisite: Physical Chemistry (PC 102)
Credit hours: Lecture: 2 Practical: 1 Total: 3
2. Course Aims:
To study the basic principles of the quantitative chemical analysis including acid-base,
precipitimetry and complexometric titration and cover the applications of these methods to
pharmaceutical compounds
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1 a1. Identify the basics of Quantitative analytical chemistry
a2. Outline the principles of volumetric analysis
A3 a3. Manage the different types of titrimetric methods
A4 a4. Describe the theories of standardization of chemicals
a5. Describe different analytical techniques for evaluation of pharmaceuticals
b. Intellectual Skills:
At the end of this course, student should be able to:
B3
b1. Determine suitable volumetric methods for analysis of drugs
b2. Investigate appropriate methods for analysis of some chemical compounds
by acid-base titration
B5 b3.
Conduct appropriate methods for determination of various chemical
compounds
b4. Select suitable methods for standardization of various chemical compounds
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C2 c1. Perform analytical experiments safely
c2. Handle chemicals appropriately
39 | P a g e
C4 c3.
Employ appropriate methods for identification of some chemical
compounds.
c4. Implement suitable methods for standardization of chemicals
C14 c5. Employ different quantitative chemical methods for assay of raw materials
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team to perform the required tasks
D9 d2. Acquire effective time management skills
D10 d3. Implement writing and presentation skills
4. Contents:
4.1.Lectures:
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Introduction to volumetric analysis 1
2. Handling of accurate measures 1
3. Determination of HCl #NaOH 1
4. Determination of HCl/acetic acid mixture 1
5. Determination of NaOH/Na2CO3 mixture 1
6. Determination of ammonium chloride by back titration 1
Study
week Topics
No. of
Credit Hours
1. Introduction to analytical chemistry, introduction to
volumetric analysis 2
2. Acid-base theories and calculations 2
3. Buffers 2
4. Acid-base indicators + Quiz 1 2
5. Titration curves 2
6. Applications of acid-base titration 2
7. Precipitimetry titration: introduction and solubility product
Ksp, titration curves for Argentometric methods 2
8. Quiz 2
9. Precipitimetry applications: Mohr’s method, Volhard method,
Fajan’s method, Liebig’s method 2
10. Complexometric titration: introduction, types of bonds,
chelating and sequestering agents 2
11. Complexometric titration: stability of complexes, EDTA
titration curves 2
12. Types of EDTA titrations 2
13. Titration of mixtures and metal ion indicators 2
14. Final Exam
Total:
2 credit hours 15.
40 | P a g e
7. Determination of aspirin by back titration 1
8. Quiz 2
9. Introduction to complexometry 1
10. Determination of MgSO4 #EDTA 1
11. Determination of Ca/Mg mixture #EDTA 1
12. Determination of NaCl by Mohr’s method 1
13. Practical Exam 1
14. Final Exam
Total:
1 credit hours 15.
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Practical experiments
5.3. Learning Management System
5.4. Homework
5.5. Brain storming
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam To assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam To assess professional and practical skills.
3. Course work To assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam To assess knowledge, understanding, intellectual skills, general skills
and confidence.
5. Quizzes To assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (research activity.) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Oral exam 14th & 15th weeks
Assessment 6 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (research activity) 5
41 | P a g e
2. Final-Term Exam 40
3. Oral Exam 10
4. Practical Exam 25
Total 100%
7. List of References:
No. Reference Type
1. Analytical Chemistry, Gary D. Christian, 6th ed. John Wiely and
Sons,2004, New York. Textbook
2. Dean’s Analytical Chemistry Handbook, Pradyot Patanik, Second
Edition, 2004, McGraw Hill, New York Textbook
3. Fundamentals of Analytical Chemistry, 9th ed., 2014, Douglas,A.
Skoog and Donald M. West.Sounder’s College Publishing, Japan. Textbook
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
Introduction to analytical
chemistry, introduction to
volumetric analysis
a1,a2 -- -- --
2. Acid-base theories and
calculations a3,a4,a5 b1, b4 c3 --
3. Buffers a1 b1,b2 -- d2
4. Acid-base indicators + Quiz 1 a1,a2 b1,b2 c3,c4 d2
5. Titration curves a1,a2,a3 b1,b2 c5 d2
6. Applications of acid-base
titration a1,a2,a3 b3,b1,b2 c3,c4,c5 d2
7.
Precipitimetry titration:
introduction and solubility
product Ksp, titration curves for
Argentometric methods
a1,a2,a3 b1,b2 c3,c4 d2
9.
Precipitimetry applications:
Mohr’s method, Volhard
method, Fajan’s method,
Liebig’s method
a1,a2,a3 b1,b2 c1,
c3,c5 d2
10.
Complexometric titration:
introduction, types of bonds,
chelating and sequestering
agents
a1,a2, a5 b1,b2 c3,c4 d2
11.
Complexometric titration:
stability of complexes, EDTA
titration curves
a2,a4,a5 b1,b2 c3,c4 d2
42 | P a g e
12. Types of EDTA titrations a1,a2, a5 b1,b2
c3,c4 d2
13. Titration of mixtures and metal
ion indicators
a1,a2,a4 b3,b1,b2 c3,
c4,c5
d2
8.2. Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Introduction to volumetric analysis a2 -- c3 --
2. Handling of accurate measures a1,a2 b4 c1,c2 --
3. Determination of HCl #NaOH a3 b1,b3 c2,c3,c5 d3
4. Determination of HCl/acetic acid
mixture a2,a3 b1,b3,b4 c1, c3,c5 d1
5. Determination of NaOH/Na2CO3
mixture a2,a3 b3,b4 c1,c2, c5 d3
6. Determination of ammonium
chloride by back titration a2,a3 b1,b3,b4 c1,c2,c3 d2
7. Determination of aspirin by back
titration a2,a3 b2,b5 c2, c4,c5 d2
9. Introduction to complexometry a2,a3 b1,b3,b4 c3,c4,c5 d1
10. Determination of MgSO4 #EDTA a2,a3 b1,b3 c1,c2,c5 d3
11. Determination of Ca/Mg mixture
#EDTA a2,a3 b3,b4 c1,c2,c5 d2
12. Determination of NaCl by Mohr’s
method a2,a3 b1,b3 c1,c2,c5 d1
Name Signature
Course Coordinator: Dr. Mary Wahba
Head of Department: Prof. Dr Dalia El Wasseef
Approval Date 5/02/2018
43 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Pharmaceutical Analytical Chemistry-2
Course Code: PC 222
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Spring Semester 2017/2018 Level two
Prerequisite: Pharmaceutical Analytical Chemistry-1 (PC 121)
Credit hours: Lecture: 2 Practical: 1 Total: 3
2. Course Aims:
To study the principle of quantitative chemical methods of analysis, Demonstrate basic
principles of redox reactions, Covers conductometric methods of analysis, Provides basic
concepts of spectroscopy
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A3 a1. Identify the different analytical techniques as spectrophotometry and
conductometry.
A4 a2. Enumerate the theories of evaluation of pharmaceuticals by redox reactions
a3. Describe the theories of standardization of chemicals
A7 a4. Recognize the principles of various instruments and techniques used in
pharmaceutical analysis
A13 a5. Explain the chemical properties of pharmaceutically active ingredients.
b. Intellectual Skills:
At the end of this course, student should be able to:
B3 b1. Determine suitable methods of analysis of drugs as raw materials
b2. Verify appropriate methods of analysis of pharmaceutical compounds
B5
b3. Design appropriate methods for evaluation of various chemical compounds
b4. Develop suitable methods for standardization of various chemical
b5. Adopt appropriate analytical methods for standardization of pharmaceutical
compounds
44 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C2 c1. Handle and dispose chemicals safely
C4 c2.
Select appropriate methods for identification of active substances from
different origins
c3. Implement suitable methods for standardization of active materials
C8 c4. Manipulate pharmaceutical instruments and equipment safely and efficiently
and solve commonly encountered problems in pharmaceutical analysis.
C14 c5. Employ different quantitative chemical methods for assay of raw materials
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team to perform the required tasks
D9 d2. Acquire effective time management skills
D10 d3. Implement writing and presentation skills
4. Contents:
4.1.Lectures:
Study
week Topics
No. of
Credit Hours
1. Redox reactions, Introduction, Factors affecting redox
potential, Methods for detection of end point: 2
2. REDOX STANDARDS & APPLICATIONS:
(A) OXIDIZING AGENTS, KMnO4: Advantages and
disadvantages, Applications
2
3. Ce(SO4)2:Advantages and disadvantages.Applications:
K2Cr2O7:Advantages and disadvantages, Applications 2
4.
KBrO3:Preparation of standard Br2, applications:
I2: Properties. Iodimetry & Iodometry. Applications
Quiz 1
2
5. REDUCING AGENTS
(1) FeSO4. (2) Na2S2O3 2
6. Pharmaceutical Applications 2
7. Electro chemistry
Introduction to electrochemistry 2
8. Quiz 2
9. Galvanic and electrolysis cells 2
10. Conductometry: theory and application 2
11. Spectrophotometry
Introduction Components of spectrophotometer 2
45 | P a g e
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Introduction to redox titration 1
2. Determination of KMnO4 # oxalic acid 1
3. Determination of K2CrO4 by iodometry 1
4. Determination of CuSO4 by iodometry 1
5. Andrews method 1
6. Determination of H2O2 1
7. Determination of ascorbic acid 1
8. Quiz 2
9. Introduction to spectrophotometry 1
10. Drawing of absorption spectrum and calibration curve 1
11. Drawing of absorption spectrum of KMnO4 by
spectrophotometry 1
12. Drawing of calibration curve of KMnO4 by spectrophotometry 1
13. Practical Exam 1
14. Final Exam
Total:
1 credit hour 15.
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Practical experiments
5.3. Learning Management System
5.4. homework
5.5. Brain storming
12. Types of spectrophotometers:
Beer-Lambert law 2
13. Factors affecting absorption spectrum: Applications 2
14. Final Exam
Total:
2 credit hours 15.
46 | P a g e
6. Student Assessment Methods:
6.1. Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam to assess professional and practical skills.
3. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam to assess knowledge, understanding, intellectual skills, general skills
and confidence.
5. Quizzes to assess knowledge, understanding and intellectual skills.
6.2. Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (research activity) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Oral exam 14th & 15th weeks
Assessment 6 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (research activity) 5
2. Final-Term Exam 40
3. Oral Exam 10
4. Practical Exam 25
Total 100%
7. List of References:
No. Reference Type
1. Analytical Chemistry, Gary D. Christian, 6th ed. John Wiely and
Sons, 2004, New York. textbook
2. Fundamentals of Analytical Chemistry, 9th ed., 2014, Douglas, A.
Skoog and Donald M. West.Sounder’s College Publishing, Japan. textbook
47 | P a g e
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
Redox reactions,
Introduction, Factors
affecting redox potential,
Methods for detection of
end point:
a2,a3 b1 c2 --
2.
REDOX STANDARDS &
APPLICATIONS:
(A) OXIDIZING AGENTS,
KMnO4: Advantages and
disadvantages, Applications
a3 b5 c2,c3 d2
3.
Ce(SO4)2:Advantages and
disadvantages.Applications:
K2Cr2O7:Advantages and
disadvantages, Applications
a2,a3 b2,b3,b5 c2,c5 d3
4.
KBrO3:Preparation of standard
Br2., Applications:
I2:Properties., Iodimetry &
Iodometry. Applications
a1,a2,a3 b1,b4,b5 c2,c3,c5 d2
5. REDUCING AGENTS
(1) FeSO4.
(2) Na2S2O3
a2,a3,a5 b1, b3, b5 c2,c3,c5 d2
6. Pharmaceutical Applications a1,a2,a5 b2, b3, b5 c2,c3,c5 d3
7.
Electro chemistry
Introduction to
electrochemistry
a1,a4 b1,b2 c3,c4,c5 d2
9. Galvanic and electrolysis cells a1,a4 b1,b2 c3,c4,c5 d2
10. Conductometry: theory and
application a1,a4,a5 b1,b2 c2,c3,c4 d3
11.
Spectrophotometry
Introduction Components of
spectrophotometer
a1,a4,a5 b1,b2 c2,c3, c5 d2
12. Types of spectrophotometers:
Beer-Lambert law a1,a4,a5 b1,b2 c2, c4,c5 d3
13. Factors affecting absorption
spectrum: Applications a1,a4,a5 b1,b2 c2,c3, c5 d2
48 | P a g e
8.2.Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Introduction to redox titration a2 b1,b3 c1,c2 --
2. Determination of KMnO4 # oxalic
acid a2,a5 b1,b3 c1, c3,c5 d2
3. Determination of K2CrO4 by
iodometry a2,a5 b1,b3 c1, c3,c5 d2
4. Determination of CuSO4 by
iodometry a2,a5 b1,b3 c1, c3,c5 d2
5. Andrews method a2,a5 b1,b3 c1, c3,c5 d2
6. Determination of H2O2 a2,a5 b1,b3 c1, c3,c5 d1
7. Determination of ascorbic acid a2,a5 b2 c1, c3,c5 d2
9. Introduction to spectrophotometry a1,a3,a5 b1,b3 c1, c3,c5 d1
10. Drawing of absorption spectrum
and calibration curve a1, a4,a5 b1,b3 c1, c4,c5 d3
11. Drawing of absorption spectrum of
KMnO4 by spectrophotometry a1, a4,a5 b1,b3 c1, c3,c4 d1
12. Drawing of calibration curve of
KMnO4 by spectrophotometry a1,a4 b1,b3 c1, c4,c5 d3
Name Signature
Course Coordinator: Dr. Mohamed El Awady
Head of Department: Prof. Dr Dalia El Wasseef
Approval Date 5/02/2018
49 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Quality Control
Course Code: PC 522
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Fall Semester 2017/2018 Level: Five
Prerequisite: Pharmaceutical Analytical Chemistry-2 (PC 222)
Credit hours: Lecture: 2 Practical: 1 Total: 3
2. Course Aims:
To inform students with the quality assurance establishments, the relevant activities
and good laboratory practice (GLP) guidelines. In addition, to learn the students what are the
quality management and quality control activities in pharmaceutical industries and in clinical
investigation units. Furthermore, to illustrate quality assurance and regulatory matters
referring. principals of analytical techniques and the evaluation of official monographs. The
practical module is designed to familiarize undergraduates with the validation parameters
according to ICH guidelines, evaluation of impurities in pharmaceutical compounds and
estimation of the some pharmaceutical dosage forms using spectrophotometric technique
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A3 a1. Recognize the different analytical techniques using GLP guidelines and
validation procedures.
A7 a2. Recall the principles of various instruments and techniques in pharmaceutical
industry
A23 a3. Identify the principles of quality assurance of pharmaceutical processes
A24 a4. Distinguish appropriate quality control criteria to different aspects of
pharmaceutical industry
A20 a5. Summarize the approval process of newly introduced pharmaceutical
products
b. Intellectual Skills:
At the end of this course, student should be able to:
B2 b1. Discriminate between good laboratory practices (GLPs) and good measurement
practices (GMPs) in quality control laboratories.
50 | P a g e
B3 b2. Examine suitable methods of analysis and quality control of drugs as raw material
and in dosage forms
B5 b3. Determine appropriate methods for evaluation and standardization of various
pharmaceutical compounds
B13 b4. Interpret experimental data based on relevant pharmaceutical and statistical
principles
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C8
c1. Manipulate pharmaceutical instruments and equipment safely and efficiently
c2 Solve commonly encountered problems in pharmaceutical manufacturing
processes
C14 c3. Employ different quantitative chemical methods for quality control
c4 Assay of raw materials and pharmaceutical preparations
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1. Work effectively as a part of a team to perform the required tasks
D4 d2. Collect, evaluate and present data in accordance with standard statistical methods
D9 d3. Acquire effective time management skills
D13 d4. Comply with quality measures in conducting tasks
4. Contents:
4.1.Lectures:
Study
week Topics
No. of
Credit Hours
1. General introduction to quality assurance and quality control
(definitions, responsibilities, and advantages) 2
2.
The role of quality control in pharmaceutical industry (receipt,
sampling process, sampling tools, testing, and analysis)
Laboratory data, retained samples, control of starting material
acceptance, laboratory reagent, stability study, laboratory
documentation.
2
3.
Good laboratory practices (GLPs), good measurement
practices (GMPs),
Standard operating procedures (SOPs) (definition, rules, basic
structure of SOPs, styles and examples)
2
4.
Laboratory notebooks (worksheets), protocol for specific
purposes (PSP)
Quality assessment:
Internal method for quality assessment (analysis of duplicate
samples, the analysis of blanks, analysis of standards, and spike
recoveries) + (Quiz 1)
2
51 | P a g e
4.2.Practical:
Study
week Topics
No. of
Credit Hours
1. Introduction to quality control and standard operating procedure &
monographs and how to use British Pharmacopeia CD?. 1
2. Validation parameters: Accuracy 1
3. Validation parameters: Precision 1
4. Validation parameters: Linearity and Range 1
5. Spectrophotometric validation of aspirin tablets 1
6. Spectrophotometric validation of theophylline injection 1
7. Validation parameters: Specificity and Robustness 1
8. Quiz 2
9. Evaluation of impurities in pharmaceutical compounds 1
10. Limit test for salicylic acid in aspirin tablet 1
11. Limit test for chloride 1
12. Limit test for sulfate and iron 1
13. Practical Exam
14. Final Exam
Total:
1 credit hour 15.
5.
Quality assessment:
i- External method for quality assessment (proficiency
standards)
Evaluating quality assurance data
i- Prescriptive approach
2
6.
Evaluating quality assurance data:
Performance based approach (construction of property control
charts, interpreting control charts, using control charts for quality
assurance)
2
7. Different chromatographic techniques (1) 2
8. Quiz 2
9. Different chromatographic techniques (2) 2
10. Interpretation of chromatograms 2
11. Validation procedures 2
12. Official methods of analysis 2
13. Bioavailability testing & Documentation 2
14. Final Exam
Total:
2 credit hours 15.
52 | P a g e
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Practical Experiments
5.3. Learning Management System (L.M.S)
5.4. Homework
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam To assess knowledge, understanding, and intellectual skills
2. Practical exam To assess professional and practical skills.
3. Course work To assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Oral exam To assess knowledge, understanding, intellectual skills, general skills and
confidence.
5. Quizzes To assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/Activity (Research Activity) all over the term
Assessment 4 Practical exam 13th week
Assessment 5 Oral exam 14th & 15th weeks
Assessment 6 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (research activity) 5
2. Final-Term Exam 40
3. Oral Exam 10
4. Practical Exam 25
Total 100%
7. List of References:
No. Reference Type
1. Harvey, D., Modern analytical chemistry. Vol. 381. 2000: McGraw-
Hill New York. Textbook
53 | P a g e
2.
ICH guidelines Q10 (Pharmaceutical Quality System).
WHO Guidelines for Sampling of Pharmaceutical Products and
Related Materials.
Guidelines
3. BP 2013, CD. Pharmacopeia
4.
www.who.int/medicines/areas/quality_safety/.../QualityAssurancePha
rmVol2.pdf &
http://whqlibdoc.who.int/trs/WHO_TRS_929_eng.pdf
Website
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
General introduction to quality
assurance and quality control
(definitions, responsibilities, and
advantages)
a3, a4 -- -- --
2.
The role of quality control in
pharmaceutical industry (receipt,
sampling process, sampling tools,
testing, and analysis)
Laboratory data, retained samples,
control of starting material
acceptance, laboratory reagent,
stability study, laboratory
documentation.
a3, a4,
a5 b1 ,b2 c2 d2, d4
3.
Good laboratory practices (GLPs),
good measurement practices
(GMPs),
Standard operating procedures
(SOPs) (definition, rules, basic
structure of SOPs, styles and
examples)
a1, a3,
a5 b1, b3 c1, d1, d3
4.
Laboratory notebooks
(worksheets), protocol for specific
purposes (PSP)
Quality assessment:
Internal method for quality assessment
(analysis of duplicate samples, the
analysis of blanks, analysis of
standards, and spike recoveries)
a1, a3,
a4, a5 b2, b3 c3 d2, d4
5.
Quality assessment:
ii- External method for quality
assessment (proficiency
standards)
Evaluating quality assurance data
ii- Prescriptive approach
a3, a4,
a5 b2, b4 c2 d2, d4
54 | P a g e
6.
Evaluating quality assurance data:
Performance based approach
(construction of property control
charts, interpreting control charts,
using control charts for quality
assurance)
a3, a4,
a5 b2, b4 c2 d2, d4
7. Different chromatographic techniques
(1) a2 b2, b3 c2, c3 -
9. Different chromatographic techniques
(2) a2 b2, b3 c2, c3 -
10. Interpretation of chromatograms a2 b2, b3 c2, c3 d2
11. Validation procedures a1, a3 b4 c4 d2, d4
12. Official methods of analysis a3 b2, b3 c3, c4 d4
13. Bioavailability testing &
Documentation a4 b2, b3 c3 d4
8.2.Practical:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
Introduction to quality control and
standard operating procedure &
monographs and how to use British
Pharmacopeia CD?
a3 b2, b3 -- --
2. Validation parameters: Accuracy a1, a3 b4 c4 d2, d4
3. Validation parameters: Precision a1, a3 b4 c4 d2, d4
4. Validation parameters: Linearity and
Range a1, a3 b4 c4 d2, d4
5. Spectrophotometric determination of
aspirin tablets a2 b2 c1, c3, c4 d1, d2
6. Spectrophotometric determination of
furosemide injection a2 b2 c1, c3, c4 d1, d2
7. Validation parameters: Specificity and
Robustness a1, a3 b4 c4 d2, d4
9. Evaluation of impurities in
pharmaceutical compounds a2 b2 c4 d4
55 | P a g e
10. Limit test for salicylic acid in aspirin
tablet a2 b2 c4 d4
11. Limit test for chloride a2 b2 c4 d4
12. Limit test for sulfate and iron a2 b2 c4 d4
Name Signature
Course Coordinator: Dr. Mohamed Kaddah
Head of Department: Prof. Dr Dalia El Wasseef
Approval Date 10/09/2017
56 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Food Analysis
Course Code: PC 524
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical Chemistry
Academic year/ level: Spring Semester 2017/2018 Level five
Prerequisite: None
Credit hours: Lecture: 2 Practical: 0 Total: 2
2. Course Aims:
To study the basic principles of the procedures commonly used to analyze food and to use the
laboratory techniques related to these procedures. In addition, to make the students well-
informed with the chemical composition of different food products and the official guidelines
for sampling and analysis of food products including analysis of specific food components,
e.g. lipids, proteins, water, carbohydrates, vitamins, minerals….etc
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1 a1. Identify the principles of food chemistry.
A2 a2. Recognize the physico-chemical characteristics of food substances
A7 a3.
Recall the principles of various instruments and techniques including
manufacturing and storing processes in food industry.
A13 a4. Recall the chemical properties of food products
A15 a5. Define the basis of nutrition facts labelling
b. Intellectual Skills:
At the end of this course, student should be able to:
B3 b1. Determine suitable methods of analysis raw food materials
b2. Verify appropriate methods of analysis and quality control of food products
B5 b3.
Design appropriate methods for isolation, identification and evaluation of
various food products
b4. Develop suitable methods for standardization of chemical food components
B13 b5. Interpret experimental data based on relevant chemical principles
57 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C4
c1. Select appropriate methods of analysis and quality control of food products
c2. Implement appropriate methods for isolation, identification and evaluation of
various food products
c3 Utilize suitable methods for extraction of active materials from foods of
different origins
C8 c4
Manipulate analytical instruments and solve commonly encountered
problems in food manufacturing processes
C11 c5
Conduct research studies, including: analysis, interpretation and presentation
of results
d. General and Transferable Skills:
At the end of this course, student should be able to:
D4 d1. Present data in accordance with standard statistical methods
D6 d2. Develop the skills required for continued self learning
D10 d3. Implement writing and presentation skills
4. Contents:
4.1.Lectures:
4.2.Practical: Not applicable
Study
week Topics
No. of
Credit Hours
1. General introduction on food analysis, official sources of
information 2
2. Governmental regulations and international standards. 2
3. Nutrition labeling and its official FDA regulations. 2
4. Sampling and sampling plan in food analysis
Quiz 1 2
5. Moisture and total solids analysis. 2
6. Ash analysis and specific minerals analysis. 2
7. Protein analysis. 2
8. Quiz 2
9. Analysis of lipids (fats & oils): Determination of total lipid
content 2
10. Analysis of lipids (fats & oils): Determination of lipid
composition & oxidation. 2
11. Carbohydrate analysis. 2
12. Analysis of drinking water. 2
13. Applications 2
14. Final Exam
Total:
2 credit hours 15.
58 | P a g e
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Learning Management System
5.3. Indirect learning (Homework & assignments)
5.4. Brain storming
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
3. Quizzes to assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (research activity) all over the term
Assessment 4 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (research activity) 5
2. Final-Term Exam 75
Total 100%
7. List of References:
No. Reference Type
1. Food Analysis (Fourth Edition, 2010) by S. Suzanne Nielsen Textbook
2. www.fda.org Website
3. AOAC International Periodical
59 | P a g e
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1.
General introduction on food
analysis, official sources of
information
a1 b4 -- d2
2. Governmental regulations and
international standards. a1,a2,a5 b3,b4 c1,c2,c3 d2
3. Nutrition labeling and its
official FDA regulations. a1,a5 b3,b4 c1,c2, c4 d2
4. Sampling and sampling plan in
food analysis a3,a5 b3,b4 c4 d2
5. Moisture and total solids
analysis. a2,a3 b1, b2, b4 c2,c3,c4 d1,d3
6. Ash analysis and specific
minerals analysis. a2,a3,a4 b1,b3,b5 c1, c2,c4 d1,d3
7. Protein analysis. a3,a4 b3,b4,b5 c1,c3,c5 d1,d3
9.
Analysis of lipids (fats & oils):
Determination of total lipid
content
a3,a4 b1,b2, b4 c1, c2,c3 d1,d3
10.
Analysis of lipids (fats & oils):
Determination of lipid
composition & oxidation.
a2,a3 b3,b4,b5 c1, c2,c5 d1,d2
11. Carbohydrate analysis. a1,a2,a4 b1, b2,b3 c1,c4,c5 d1,d3
12. Analysis of drinking water. a3,a4 b1,b3,b4 c1, c2, c5 d2,d3
13. Applications a3,a4 b1,b2,b4 c2,c4,c5 d1,d2
Name Signature
Course Coordinator: Dr. Samah Abo El-Abbas
Head of Department: Prof. Dr Dalia El Wasseef
Approval Date 5/02/2018
60 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: General physics
Course Code: PC 103
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical chemistry
Academic year/ level: Spring Semester 2017/2018 Level 1
Prerequisite: Non
Credit hours: Lecture: Practical: Total:
2. Course Aims:
2.1 To understand the general physics concepts which is related to pharmaceutical field.
2.2 Cover the basic branches in solid and liquid mechanics, hydrostatics, hydrodynamics as
well as thermodynamics, electricity, magnetism, sound waves and application of these
concepts in pharmacy.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1
a1 Describe the concepts of solid mechanics, electricity, and optics, and give
examples to their applications in pharmacy
a2
Develop a clear understanding of basic concepts of radioactivity and nuclear
medicine and Outline the different types of magnetism and nuclear magnetic
resonance
A7
a3 Identify different types of waves and outline the properties of sound waves
a4 Discuss the meaning of thermodynamics laws, heat, temperature and its effect on
drug stability.
b. Intellectual Skills:
At the end of this course, student should be able to:
B2
b1 Asses safety aspects of electric force, the electric field and the electric potential,
and Identify chemical properties of drug by sound and ultrasound waves
b2 Determine the photon and heat effect on drug, degradation and investigate
different mechanical properties of matter.
B16 b3 Differentiate between the meaning of the temperature and the quantity of heat.
b4 Investigate the spectroscopic analysis and the atomic structure.
61 | P a g e
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C11
c1 Analyze the physical parameters graphically and experimentally, and Utilize the
physics concepts , techniques ,and tools in solving problems
c2
Illustrate the electric field intensity and the electric potential and its applications
in pharmaceutical industry, and measure the power and focal length of the mirror
and lenses.
C15 c3
Apply the bio-magnetic field theory in the magnetic resonance imaging, and
sound waves in medicine.
c4 Handle the radiotherapy techniques.
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1 Work Effectively as a part of team
D9 d2 Acquire effective time management
4. Contents:
4.1. Lectures
No. Topic No. of Credit hours
1 Solid mechanics 2
2 Fluid mechanics 2
3 Heat 2
4 Temperature + (quiz 1) 2
5 Sound and ultrasound 2
6 Nuclear and radiation 2
7 Optics 2
8 Quiz 2
9 Electricity 2
10 Magnetism and MRI 2
11 Laser 2
12 Thermodynamics 2
13 Modern physics 2
14 Final exam
Total
2 credit hours 15
62 | P a g e
4.2.Practical:
No. Topic No. of
Credit hours
1 Fine measurements 1
2 determination of specific heat of solid 1
3 determination viscosity coefficient 1
4 Metric bridge 1
5 Drawing and calculations 1
6 problems solving 1
7 determination of lens power 1
8 Quiz 2
9 determination of mirror power 1
10 tangent galvanometer 1
11 determination of sound speed in air 1
12 drawing and calculation 1
13 Practical exam 1
14 Final exam
Total
1 credit hour 15
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Practical classes
5.3. e-learning (Moodle)
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam To assess knowledge, understanding, intellectual and professional
skills.
2. Practical exam To assess professional and practical skills.
3. Course work To assess knowledge, understanding, intellectual skills, general &
transferable skills.
4. Quizzes To assess knowledge, understanding and intellectual skills.
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (posters.) all over the term
Assessment 4 Practical exam 13th week
Assessment 6 Written exam 14th & 15th weeks
63 | P a g e
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (poster) 10
2. Final-Term Exam 50
3. Practical Exam 20
Total 100%
7. List of References:
No. Reference type
1 Physics in Biology and Medicine, 4th Edition. Paul Davidovits
(2017). Textbook
2 Physics for scientist and engineers 4th Ed. R.A Serway. 2017.
Cengage learning India private limited. Textbook
3 www.explorelearign.com Website
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course contents
ILOs
K&U IS P&PS G&TS
1 Solid mechanics a1 b3 c1 d1
2 Fluid mechanics a1 b3 c1 d1
3 Heat a4 b3 c1 d1
4 Temperature a4 b3 c1 d1
5 Sound and ultrasound a3 b1 c3 d3
6 Nuclear and radiation a2 b4 c4 d3
7 Optics a1 b2 c2 d1
9 Electricity a1 b3 c2 d3
10 Magnetism and MRI a2 b3, b4 c3 d3
11 Laser a1 b4 c4 d3
12 Thermodynamics a4 b3 c1 d1
13 Modern physics a2 b4 c4 d1
64 | P a g e
8.2.Practical:
Study
week Course contents
ILOs
K&U IS P&PS G&TS
1 Fine measurements a1 b3 c1 d1
2
determination of
specific heat of
solid
a1 b3 c1 d1
3 determination
viscosity coefficient a4 b3 c1 d1
4 Metric bridge a4 b3 c1 d1
5 Drawing and
calculations a3 b1 c3 d3
6 problems solving a2 b4 c4 d3
7 determination of
lens power a1 b3 c2 d3
9 determination of
mirror power a1 b3 c2 d3
10 tangent
galvanometer a2 b3, b4 c3 d3
11 determination of
sound speed in air a1 b4 c4 d3
12 drawing and
calculation a4 b3 c1 d1
Name Signature
Course Coordinator: Dr. Ehab Hegazy
Head of Department: Prof. Dalia Rashad
Approval Date 5-2-2018
65 | P a g e
Delta University for Science and Technology
Quality Assurance Center
Course Specifications
1. Basic Information:
Course Title: Mathematics
Course Code: PC 101
Program on which the course is given: B. Pharm.
Department offering the course: Pharmaceutical chemistry
Academic year/ level: Fall Semester 2017/2018 Level one
Prerequisite: None
Credit hours: Lecture: 2 Practical: 0 Total: 2
2. Course Aims:
This course aims at providing the students with the mathematical principles of functions
and graphs, exponential, logarithmic, and trigonometric functions as well as differential and
integral calculus.
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A1 a1. Identify the principles of mathematics and its pharmaceutical applications.
A17
a2. Distinguish between the sets, sets operations, function types.
a3. Identify the concept of differentiation and integration and their
pharmaceutical applications.
b. Intellectual Skills:
At the end of this course, student should be able to:
B6
b1. Differentiate between the numbers’ sets and their operations to be used in
pharmaceutical calculations.
b2. Solve different mathematical problems by applying types of functions.
b3. Apply mathematical approaches for different pharmaceutical problems.
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C11 c1. Conduct experimental studies, including: presentation, analysis and
interpretation of the results
C14 c2. Employ different quantitative mathematical operations for different chemical
and biological analysis.
66 | P a g e
d. General and Transferable Skills:
At the end of this course, student should be able to:
D4 d1 Collect, evaluate and present data
D9 d2 Acquire effective time-management skills
4. Contents:
4.1.Lectures:
4.2.Practical: N/A
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Homework
6. Student Assessment Methods:
6.1.Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional
skills.
2. Course work to assess knowledge, understanding, intellectual skills, general &
transferable skills.
3. Quizzes to assess knowledge, understanding and intellectual skills.
Study
week Topics
No. of
Credit Hours
1. Sets and Sets Operations (1) 2
2. Sets and Sets Operations (2) 2
3. Advanced Operation on Sets 2
4. Exponentiation and Functions + Quiz 1 2
5. Functions Definition 2
6. Function Types (1) 2
7. Function Types (2) 2
8. Quiz 2
9. Exponential & Logarithmic Functions (1) 2
10. Exponential & Logarithmic Functions (2) 2
11. Trigonometric Functions (1) 2
12. Trigonometric Functions (2) 2
13. Differentiation and integration 2
14. Final Exam
Total: 2 credit
hours 15.
67 | P a g e
6.2.Assessment schedule:
Assessment 1 Quiz 1 4th week
Assessment 2 Quiz 2 8th week
Assessment 3 Assignment/activity (homework) all over the term
Assessment 6 Written exam 14th & 15th weeks
6.3.Weighing of Assessments:
1. Course work:
- Quiz 1 10
- Quiz 2 10
- Assignment/activity (homework) 5
2. Final-Term Exam 75
Total 100%
7. List of References:
No. Reference Type
1. Schaum's Mathematical Handbook of Formulas and Tables, 2000 textbook
2. Mathematics and Statistics for Use in Pharmacy, Biology, and
Chemistry, latest edition. textbook
8. Matrix of course contents versus ILOs:
8.1. Lectures:
Study
week Course Contents
ILOs
K&U IS P&PS G&TS
1. Sets and Sets Operations (1) a1, a2 b1 c1,c2 -
2. Sets and Sets Operations (2) a2 b1 c1,c2 -
3. Advanced Operation on Sets a2 b1 c1,c2 d1
4. Exponentiation and Functions a2 b1 c1 d1
5. Functions Definition a2 b1 - d1
6. Function Types (1) a2 b1 c1 d1
7. Function Types (2) a2 b2 c1 d1
9. Exponential & Logarithmic Functions (1) a3 b2 c1 d1
10. Exponential & Logarithmic Functions (2) a3 b3 c1 d1
11. Trigonometric Functions (1) a3 b2 - d1
12. Trigonometric Functions (2) a3 b2 - d1
13. Differentiation and integration a3 b3 c1 d1
Name Signature
Course Coordinator: Dr. Noha El-Attar
Head of Department: Prof. Dr. Dalia Rashad
Approval Date 10/9/2017
68 | P a g e
Other Courses Not Opened for Registration
at Academic Year (2017-2018)
Final Approval 2016-2017
69 | P a g e
1. Basic Information:
Course title: Advanced instrumental analysis
Course code: PC 423
Program on which the course is given: B. Pharm.
Department: Pharmaceutical chemistry
Academic level: Elective course
Prerequisite: None
Credit hours: Lecture :2 Practical: ---- Total: 2
2. Course Aims:
Giving the principle of quantitative chemical methods of analysis, Covers electro-analytical
methods of analysis, Provides basic concepts of spectroscopy and chromatography
3. Intended Learning Outcomes (ILOs):
a. Knowledge and understanding:
At the end of this course, student should be able to:
A3 a1 Manage the different analytical techniques
A4 a2 Enumerate the theories of evaluation and standardization of chemicals and
pharmaceuticals
b. Intellectual Skills:
At the end of this course, student should be able to:
B3 b1 Determine suitable methods of analysis of drugs as raw materials and in dosage
forms
B5 b2 Design appropriate methods for identification and standardization of various
chemical and pharmaceutical compounds
c. Professional and Practical Skills:
At the end of this course, student should be able to:
C2 c1 Handle and dispose chemicals safely
C4 c2 Select appropriate methods for identification and standardization of active
substances from different origins
C8 c3 Manipulate pharmaceutical instruments and equipment safely and efficiently and
solve commonly encountered problems in pharmaceutical analysis.
C14 c4 Employ different quantitative chemical methods for assay of raw materials
d. General and Transferable Skills:
At the end of this course, student should be able to:
D3 d1 Work effectively as a part of a team to perform the required tasks
D9 d2 Acquire effective time management skills
D10 d3 Implement writing and presentation skills
70 | P a g e
4. Contents:
4.1.Lectures:
Week
No. Topics
No. of
Credit
hours
1.
Spectrophotometry
Introduction:
Electromagnetic radiation (EMR).
Properties of light:
(a) as waves.
(b) as particles.
Chromophores.
Auxochromes.
2
2.
Components of spectrophotometer:
Light source.
Wavelength selector (monochromator):
Filters.
Prisms.
Gratings.
Sample compartment and cuvette.
Detector:
Phototube.
Photomultiplier.
Readout device
2
3.
Types of spectrophotometers:
(a) Single-beam spectrophotometer.
(b) Double-beam spectrophotometer.
Beer-Lambert law:
Definitions and equations.
Problems.
Deviations of Beer’s law
2
4.
Factors affecting absorption spectrum:
(1) Effect of pH:
Phenol.
Aniline.
(2) Effect of Dilution.
(3) Effect of Solvent.
(4) Effect of Temperature.
Applications:
(a) Qualitative applications.
(b) Quantitative applications:
Steps for a spectrophotometric determination.
2
71 | P a g e
5.
Electro chemistry: Introduction to electrochemistry:
Ionic pressure and Electrolytic solution pressure
Galvanic and electrolysis cells
Daniel cell
Liquid junction potential and role of salt bridge
2
6.
Potentiometry:
Reference electrodes:
Standard hydrogen electrode (diagram, half reaction,
potential,disadvantages)
Saturated calomel electrode (diagram, half reaction,
potential, disadvantages)
Indicator electrodes (glass electrode):
(diagram, composition, theory of operation, disadvantages)
Applications
Potentiometric titration curves (zero, first, second), location of EP
on curves.
2
7. Mid-Term exam
8.
Polarography:
*polarograph: parts, function of auxiliary electrode and
potentiostst).
*Polarogram, potential range
*Advantages and drawbacks of DME
*Role of supporting electrolyte
*Oxygen waves and their removal
2
9.
Conductometry:
*Specific, molar and equivalent conductance (definition, unit, effect
of dilution on each)
*Factors affecting conductance of a solution
*Conductometric titration of HCl# NaOH and HCl # NH4OH
2
10.
Chromatography
Parts of chromatograph
Difference between normal and reversed phase
chromatography
2
11.
Difference between adsorption and partition
chromatography
Difference between size exclusion and ion exchange
chromatography
Columns used in revered phase chromatography
2
12.
Difference between silica based and polymer based
columns
Difference between gel filtration and gel permeation
chromatography
2
13. Difference between isocratic and gradient elution
NTP,HETP,K' 2
14. Final Exam
2 credit
hours4 15.
72 | P a g e
5. Teaching and Learning Methods:
5.1. Lectures
5.2. Homework and assignments
6. Student Assessment Methods:
6.1. Assessment methods:
1. Written exam to assess knowledge, understanding, intellectual and professional skills
2. Class work to assess knowledge, understanding, intellectual skills, general skills and
confidence
3. Quizzes to assess knowledge, understanding and intellectual skills
6.2. Assessment schedule:
Assessment 1 Mid-term 7th week
Assessment 2 Quiz 11th week
Assessment 3 Written 14th &15th weeks
6.3.Weighing of Assessments:
Mid-Term Exam & course work 25%
Final-Term Exam 75%
Total 100%
7. List of References:
No. Reference type
1.
Fundamentals of Analytical Chemistry
Douglas A.; Skoog ;Donald M., West, F. James Holler, Stanely, R. Crouch
Edition thThomson, Australia , 6
Textbook
2. www.mediafire.com/download/tfw77m3ewhbte0s/Animation_Spectro_Photom
ultiplier.mp4 website
8. Matrix of course contents versus ILOs:
Study
week Course contents
ILOs
knowledge and
understanding
intellectual
skills
professional
and practical
skills
general and
transferable
skills
1.
Spectrophotometry
Introduction:
Electromagnetic radiation (EMR).
Properties of light:
(a) as waves.
(b) as particles.
Chromophores.
Auxochromes.
a1 b1 c3 d1
73 | P a g e
2.
Components of
spectrophotometer:
Light source.
Wavelength selector
(monochromator):
Filters.
Prisms.
Gratings.
Sample compartment and cuvette.
Detector:
Phototube.
Photomultiplier
Readout device
a1 b1 c3 d1
3.
Types of spectrophotometers:
(a) Single-beam
spectrophotometer.
(b) Double-beam
spectrophotometer.
Beer-Lambert law:
Definitions and equations.
Problems.
Deviations of Beer’s law
a1 b1 c3 d1
4.
Factors affecting absorption
spectrum:
(5) Effect of pH:
Phenol.
Aniline.
(6) Effect of Dilution.
(7) Effect of Solvent.
(8) Effect of Temperature.
Applications:
(c) Qualitative applications.
(d) Quantitative applications:
Steps for a spectrophotometric
determination.
a1 b1 c3, c4 d1,d2
5.
Electro chemistry
Introduction to electrochemistry:
Ionic pressure and Electrolytic
solution pressure
Galvanic and electrolysis cells
Daniel cell
Liquid junction potential and role
of salt bridge
a1,a2 b2 c1, c2 d3
74 | P a g e
6.
Potentiometry:
Reference electrodes:
Standard hydrogen electrode
(diagram, half reaction,
potential,disadvantages)
Saturated calomel electrode
(diagram, half reaction, potential,
disadvantages)
Indicator electrodes (glass
electrode):
(diagram, composition, theory of
operation, disadvantages)
Applications
Potentiometric titration curves (zero,
first, second), location of EP on
curves.
a1 b2 c3,c4 d1,d3
8.
Polarography:
*polarograph: parts, function of
auxiliary electrode and potentiostst).
*Polarogram, potential range
*Advantages and drawbacks of
DME
*Role of supporting electrolyte
*Oxygen waves and their removal
a1 b1 c3 d1
9.
Conductometry:
*Specific, molar and equivalent
conductance (definition, unit, effect
of dilution on each)
*Factors affecting conductance of a
solution
*Conductometric titration of HCl#
NaOH and HCl # NH4OH
a1,a2 b2 c3,c4 d1,d2
10.
Chromatography
Parts of chromatograph
Difference between normal and
reversed phase chromatography
a1,a2 b1 c3, c4 d1,d2,d3
11.
Difference between adsorption
and partition chromatography
Difference between size exclusion
and ion exchange
chromatography
Columns used in revered phase
chromatography
a1,a2 b1 c3, c4 d1,d2,d3
12.
Difference between silica based
and polymer based columns
Difference between gel filteration
and gel permeation
chromatography
a1,a2 b1 c3, c4 d1,d2,d3
75 | P a g e
13.
Difference between isocratic and
gradient elution
NTP, HETP, K'
a1,a2 b1 c3, c4 d1,d2,d3
Name Signature
Course Coordinator: Mary Wahba
Head of Department: Prof Fatma Goda
Approval Date 12/3/2017