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Dermatology Drug for plaque psoriasis
Plaque Psoriasisthat the disease may result from a disorder in
the immune system. The immune system makes white blood cells that protect the body from infection. In psoriasis, the T cells (a type of white blood cell) abnormally trigger inflammation in the skin. These T cells also cause skin cells to grow faster than normal and to pile up in raised patches on the outer surface of the skin.
FACTOR TRIGGER PSORIASISThose with a family history of psoriasis have
an increased chance of having the disease. Some people carry genes that make them more likely to develop psoriasis. Certain factors may trigger psoriasis, such as injury to the skin, sunlight, stress, alcohol, HIV infection, smoking, and certain drugs
SIGINS AND SYMPTOMSAn individual with plaque psoriasis usually
has patches of red, raised, scaly areas on the skin that may itch or burn. The patches are usually
found on the knees, elbows, trunk, or scalp
Dermatology DrugDrug Name: Stelara (ustekinumab)
Company: Centocor Ortho Biotech
Aproval Status: Approved September 2009
Treatment Area: plaque psoriasis
What exactly is STELARA made of?The active ingredient in STELARA® is called
ustekinumab. The other ingredients are sucrose, L-
histidine, and polysorbate 80.
Mechanism of Action
Stelara (ustekinumab) is a human IgG1k monoclonal antibody that binds with high affinity and specificity to the p40 protein subunit used by both the interleukin (IL)-12 and IL-23 cytokines. IL-12 and IL-23 are naturally occurring cytokines that are involved in inflammatory and immune responses, such as natural killer cell activation and CD4+ T-cell differentiation and activation
TYPE OF FORMULATION:Stelara is supplied as a solution for
subcutaneous injection. The recommended initial dose of the drug is as follows:For patients weighing ≤100 kg (220 lbs): 45 mg initially and 4 weeks later, followed by 45 mg every 12 weeks.For patients weighing >100 kg (220 lbs): 90 mg initially and 4 weeks later, followed by 90 mg every 12 weeks. The 45 mg dose was also shown to be efficacious in this population. However, 90 mg resulted in greater efficacy in these subjects
Dosing Schedule
STELARA® Results
Everyone responds to treatments differently.
However, STELARA® patients saw at least 75% clearer skin at 12 weeks,
Cautions and contraindicationsif your doctor feels that you are at risk for
TB,
are pregnant or plan to become pregnant.
are breast-feeding or plan to breast-feed. It is thought that STELARA® passes into your breast milk
ever had an allergic reaction to STELARA
Side Effects
increase your risk for certain types of cancer
Serious Allergic ReactionsNasopharyngitis Upper respiratory tract infection Headache Fatigue Diarrhea
Everyone look for healthy and nice skin
Thanks for your attention
Prepared by : Rema’ Atyeh