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DEVELOPMENT OF CONNECTIVE TISSUE. Mesenchyme. Loose Connective Tissue. Fibers. Fibroblasts. Mesenchymal. Cells. Cell Lineage from Mesenchymal Cells. TYPES OF CONNECTIVE TISSUE. Loose Connective. Dense Irregular. Dense Regular. Tissue. Connective Tissue. Connective Tissue. - PowerPoint PPT Presentation
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DEVELOPMENT OF CONNECTIVE TISSUE
Mesenchyme Loose Connective Tissue
MesenchymalCells
Fibroblasts
Fibers
Cell Lineage from Mesenchymal Cells
TYPES OF CONNECTIVE TISSUE Loose Connective
Tissue Dense Irregular
Connective TissueDense Regular
Connective Tissue
(e.i. mesentery, omentum) (e.i. dermis of skin) (e.i. tendons, ligaments,cornea)
DENSE IRREGULAR CONNECTIVE TISSUE (DERMIS OF SKIN)
DENSE REGULAR CONNECTIVE TISSUE
Tendon (longitudinal Section) Tendon (tranverse Section)
ELASTIC CONNECTIVE TISSUE IN BLOOD VESSEL WALL
Internalelasticlamina
CONNECTIVE TISSUE FIBERS
Collagenous Fibers (bundles)
Reticular Fibers (networks)
Elastic Fibers(anastomosing bundles)
RETICULAR CONNECTIVE TISSUE
reticular fibers(argyrophilic)
COLLAGEN
FIBERBUNDLE
FiberFibril
Microfibril
Periodic Bands
Tropocollagen
alpha 1 peptidealpha 2 peptide
TEM of Collagen Fibers SEM of Collagen Fibers
SCANNING EM OF COLLAGEN FIBER BUNDLES
procollagen
tropocollagen
ground substance
(mucopolysaccharide)
RER
TEM of Fibroblast and Collagen Bundles
Collagen Types
I - skin, bone, tendon cornea (most common type)II- cartilage, embryonic corneaIII- reticular fibers, loose c.t., blood vessel walls, dermisIV- basal lamina of epithelium
(no fibers, mat of randomly-oriented molecules)
FIBROBLAST
collagen fiberbundles
TEM OF FIBROBLAST WITH COLLAGEN BUNDLES
FIXED CONNECTIVE TISSUE CELL TYPES
Fibroblast(fiber producing cell)
Fibrocyte(mesenchymal- pluropotent)
Adipocytes (fat storage)
Fixed Macrophage(histiocyte)
Adipocytes
fibroblast
Macrophage (light micrograph)
TEM of Macrophage
Fixed Connective Tissue Cells
MONONUCLEAR PHAGOCYTIC SYSTEM
Mononuclearwanderingcell
coalescence
Giant Cell
Macrophages Osteoclasts Kupffer CellsMicroglial
CellsSinusoidalEndothelia
lymph nodes
bone marrow
connective tissue
lung
serous cavities
spleenbone
resorption
liversinusoids
central nervous system
liver spleen marrow
Monocyte
(reticuloendothelial system)
( all characterized by phagocytic activity)
LYMPHOCYTES AND PLASMA CELLS (Agents of the immune response)
differentiation stimulated byimmune activation
Lymphocytes Plasma Cells(produce
immunoglobulins-antibodies)
EOSINOPHILES MAST CELLS
actively phagocyticdestroy immune complexes (antigen-antibody)
Secretion Products:1. Slow-reaction substance of anaphalaxis2. Heparin- anticoagulant3. Histamine- stimulates inflammation4. Serotonin- vasoconstrictor5. Eosinophil Chemotactic Factor
Connective Tissue Cells
Macrophage
Plasma Cell
Lymphocyte
TRANSMISSION EM OF AN EOSINOPHILE
TRANSMISSION EM OF A MAST CELL