DEVICE FOR EXTRACORPORAL PURIFICATION OF BIOLOGICAL BODY FLUIDS FROM TOXINS BY APPLICATION OF

MAGNETICALLY CONTROLLED MICROPARTICLES OF SORBENTS

Danilin A.N., Zakharov A.P., Yanovskiy Yu.G.Institute of applied mechanics RAS, Moscow, e-mail: iam@ipsun.ras.ru

Geydel А.А., Sidorin Yu.Yu.Scientific-production association “Nanometric powder materials - Kemerovo” , Kemerovo, e-mail: nano-psa@mail.ru

Alehin A.I., Goncharov N.G.Central clinical hospital RAS, Moscow, e-mail: alehin.ckb@mail.ru

Schematic diagram of the stand for investigating the detoxication processes of biological fluids by application of magnetically controlled sorbents

1 – tank, containing biological fluid with toxins;2 – unit for preparing the suspension of magnetic sorbent;3 – unit for mixing;

4 – peristaltic pump;5 – magnetic filter;6 – tank for collecting the biological fluid purified from toxins.

Version of magnetic filter design

Creation of high-gradient magnetic fields

1, 2 – end bushings with inlet and outlet pipes; 3 – bushing for additional biasing of particles; 4 – bushing for rough filtration; 5 – bushing for precise filtration; 6 – bushing made of

magnetically soft material; 7 – plastic insert in the area of precise filtration with spiral canals on its outer surface in order to arrange the flow of magnetic fluid crosswise the magnetic

field lines.

Axial section of diametrically magnetized bushing of the first

stage of magnetic separator

Versions of bushing magnetization of precise filtration area of separator in order to create high-gradient

magnetic fields (0.3-1.0 tesla/cm)

Monolithic magnetic bushings (niodim-ferrum-boron),creating high-gradient magnetic fields

Structural versions of mixer-reactor

Mixer-reactor. Assembled view

Spiral canals

Spiral canals

InsertHousing

Right and left caps (side pieces) with branch pipes

Labyrinth mixer

Peristaltic pump

Mixer

Ultrasonic disperser

Dosing pump

N

N

N

Main pipeN

N

N

N

S

S

Magnetic filter

S S

N

N

N

N

S

S

Multipole bushing of separation area

Diametrically magnetized bushing ofaggregation zone

SN

Functional scheme of the device for purification of biological body fluids from toxins and viruses by application of nano- and micro- particles of magnetically controlled sorbents

Development, magnetic sorbents, testing: IAM RAS, PSA «NPM-КЕМЕRОVО», CCH RAS

- medium to be purified (blood)

- toxins and viruses

- micro particles of magnetically controlled sorbent

Schematic diagram of the device for extracorporal detoxication of biological body fluids by application of micro-dimension magnetically

controlled sorbents

2 - peristaltic pumps

from the vein

Ultrasonic sensor

of air presence

Solution of anticoagulant

(heparin)

to the vein

3 - mixer-reactor

4 – magnetic trap

Air trap

Ultrasonic level sensor

Control, monitoring and supply

unit

Ultrasonic

radiator

1- Ultrasonic unit for dispersion of suspension of magnetically

controlled components

Suspension “concentrate”

in syringe

Experimental model of the device for detoxication of biological body fluids by application of magnetically controlled sorbents

DEVICE FOR EXTRACORPORAL DETOXICATION OF BIOLOGICAL

BODY FLUIDS

Investigation of sorption capacity of particles and their microstructure

Optical density, relative units Optical density, relative unitsOptical density, relative units

Wave length, nmWave length, nm

Fig.9. Absorption spectrums of methylene blue in physiological

solution (pH 7,2) at control (1), after adsorption by ferrocarbon (FC) for

mass ratios of FC/adsorbate: 20 (2), 30 (3), 50 (4)

Wave length, nm

Fig.10. Absorption spectrums of cyanocobalamin (vitamin B12) in physiological solution (pH 7,2) at

control (1), after adsorption by ferrocarbon (FC) for mass ratios of FC/adsorbate: 20 (2), 30 (3), 50 (4)

Fig.11. Absorption spectrums of hemoglobin in physiological solution

(pH 7,2) at control (1), after adsorption by ferrocarbon (FC) for

mass ratios of FC/adsorbate: 20 (2), 30 (3), 50 (4)